The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A

Immunity

Volumn 13, Issue 3, 2000, Pages 313-322

  Chuang, Ellen ^a,b   Fisher, Timothy S ^c   Morgan, Rodney W ^c   Robbins, Michael D ^c   Duerr, James M ^c   Vander Heiden, Matthew G ^a,d   Gardner, Joseph P ^c   Hambor, John E ^c   Neveu, Mark J ^c   Thompson, Craig B ^a,d  

^a UNIVERSITY OF CHICAGO   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; PHOSPHATASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVATION; IMMUNOSTIMULATION; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033662376     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)00031-5     Document Type: Article

References (48)

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5. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL
6. Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation
7. 2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor ζ and ZAP70
8. CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation
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19. RelA is a potent transcriptional activator of the CD28 response element within the interleukin-2 promoter
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23. + Jurkat cells facilitates CD3-T cell receptor-mediated IL-2 production
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26. The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28
27. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm
28. Regulation of protein kinase cascades by protein phosphatase 2A
29. Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152)
30. Cyclosporin A-resistant transactivation of the IL-2 promoter requires activity of okadaic acid-sensitive serine/threonine phosphatases
31. Ligation of the T cell costimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B
32. The actin cytoskeleton and lymphocyte activation
33. Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins
34. p56lck and p59fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: Implications for T cell costimulation
35. Networking Rho family GTPases in lymphocytes
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37. Upstream-downstream: CD28 cosignaling pathways and T cell function
38. TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway
39. CTLA-4 binding to lipid kinase phosphatidylinositol 3-kinase in T cells
40. Making the T cell receptor go the distance: A topological view of T cell activation
41. A CD28-associated signaling pathway leading to cytokine gene transcription and T cell proliferation without TCR engagement
42. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation
43. JNK is involved in signal integration during costimulation of T lymphocytes
44. Inhibition of protein phosphatases by okadaic acid induces AP1 in human T cells
45. The emerging role of CTLA-4 as an immune attenuator
46. Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A
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