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Volumn 9, Issue 4, 2017, Pages

High dietary fructose: Direct or indirect dangerous factors disturbing tissue and organ functions

Author keywords

High dietary fructose; Inflammation; Insulin resistance; Metabolic syndrome; Metabolites; Oxidative stress; Tissue and organ dysfunction

Indexed keywords

ADIPONECTIN; CYTOKINE; ENDOTOXIN; FATTY ACID; FRUCTOSE; GLUCOSE; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 5; LACTIC ACID; LEPTIN; METHYLGLYOXAL; URIC ACID; ADIPOCYTOKINE;

EID: 85016506995     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu9040335     Document Type: Review
Times cited : (165)

References (183)
  • 2
    • 0026021161 scopus 로고
    • Insulin resistance. A multifaceted syndrome responsible for niddm, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
    • DeFronzo, R.A.; Ferrannini, E. Insulin resistance. A multifaceted syndrome responsible for niddm, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991, 14, 173–194. [CrossRef] [PubMed]
    • (1991) Diabetes Care , vol.14 , pp. 173-194
    • Defronzo, R.A.1    Ferrannini, E.2
  • 3
    • 17144380822 scopus 로고    scopus 로고
    • The metabolic syndrome
    • Eckel, R.H.; Grundy, S.M.; Zimmet, P.Z. The metabolic syndrome. Lancet 2005, 365, 1415–1428. [CrossRef]
    • (2005) Lancet , vol.365 , pp. 1415-1428
    • Eckel, R.H.1    Grundy, S.M.2    Zimmet, P.Z.3
  • 6
    • 0027364672 scopus 로고
    • Intermediary metabolism of fructose
    • Mayes, P.A. Intermediary metabolism of fructose. Am. J. Clin. Nutr. 1993, 58, S754–S765.
    • (1993) Am. J. Clin. Nutr. , vol.58 , pp. S754-S765
    • Mayes, P.A.1
  • 9
    • 0015452391 scopus 로고
    • Fructose metabolism in adipose tissue
    • Froesch, E.R. Fructose metabolism in adipose tissue. Acta Med. Scand. Suppl. 1972, 542, 37–46. [CrossRef] [PubMed]
    • (1972) Acta Med. Scand. Suppl. , vol.542 , pp. 37-46
    • Froesch, E.R.1
  • 12
    • 79960868227 scopus 로고    scopus 로고
    • Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: A randomized controlled trial
    • Aeberli, I.; Gerber, P.A.; Hochuli, M.; Kohler, S.; Haile, S.R.; Gouni-Berthold, I.; Berthold, H.K.; Spinas, G.A.; Berneis, K. Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: A randomized controlled trial. Am. J. Clin. Nutr. 2011, 94, 479–485. [CrossRef] [PubMed]
    • (2011) Am. J. Clin. Nutr. , vol.94 , pp. 479-485
    • Aeberli, I.1    Gerber, P.A.2    Hochuli, M.3    Kohler, S.4    Haile, S.R.5    Gouni-Berthold, I.6    Berthold, H.K.7    Spinas, G.A.8    Berneis, K.9
  • 13
    • 84989843226 scopus 로고    scopus 로고
    • High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress
    • Balakumar, M.; Raji, L.; Prabhu, D.; Sathishkumar, C.; Prabu, P.; Mohan, V.; Balasubramanyam, M. High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress. Mol. Cell. Biochem. 2016, 423, 93–104. [CrossRef] [PubMed]
    • (2016) Mol. Cell. Biochem. , vol.423 , pp. 93-104
    • Balakumar, M.1    Raji, L.2    Prabhu, D.3    Sathishkumar, C.4    Prabu, P.5    Mohan, V.6    Balasubramanyam, M.7
  • 14
    • 84857426294 scopus 로고    scopus 로고
    • Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion
    • Kyriazis, G.A.; Soundarapandian, M.M.; Tyrberg, B. Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Proc. Natl. Acad. Sci. USA 2012, 109, E524–E532. [CrossRef] [PubMed]
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. E524-E532
    • Kyriazis, G.A.1    Soundarapandian, M.M.2    Tyrberg, B.3
  • 15
    • 84875410641 scopus 로고    scopus 로고
    • Quercetin preserves β-cell mass and function in fructose-induced hyperinsulinemia through modulating pancreatic Akt/FoxO1 activation
    • Li, J.M.; Wang, W.; Fan, C.Y.; Wang, M.X.; Zhang, X.; Hu, Q.H.; Kong, L.D. Quercetin preserves β-cell mass and function in fructose-induced hyperinsulinemia through modulating pancreatic Akt/FoxO1 activation. Evid.-Based Complement. Altern. Med. eCAM 2013, 2013, 303902.
    • (2013) Evid.-Based Complement. Altern. Med. Ecam , vol.2013
    • Li, J.M.1    Wang, W.2    Fan, C.Y.3    Wang, M.X.4    Zhang, X.5    Hu, Q.H.6    Kong, L.D.7
  • 16
    • 84907339991 scopus 로고    scopus 로고
    • Moderate amounts of fructose- or glucose-sweetened beverages do not differentially alter metabolic health in male and female adolescents
    • Heden, T.D.; Liu, Y.; Park, Y.M.; Nyhoff, L.M.; Winn, N.C.; Kanaley, J.A. Moderate amounts of fructose- or glucose-sweetened beverages do not differentially alter metabolic health in male and female adolescents. Am. J. Clin. Nutr. 2014, 100, 796–805. [CrossRef] [PubMed]
    • (2014) Am. J. Clin. Nutr. , vol.100 , pp. 796-805
    • Heden, T.D.1    Liu, Y.2    Park, Y.M.3    Nyhoff, L.M.4    Winn, N.C.5    Kanaley, J.A.6
  • 17
    • 0026770646 scopus 로고
    • Lactate production in adipose tissue: A regulated function with extra-adipose implications
    • DiGirolamo, M.; Newby, F.D.; Lovejoy, J. Lactate production in adipose tissue: A regulated function with extra-adipose implications. FASEB J. 1992, 6, 2405–2412. [PubMed]
    • (1992) FASEB J , vol.6 , pp. 2405-2412
    • Digirolamo, M.1    Newby, F.D.2    Lovejoy, J.3
  • 18
    • 12744280758 scopus 로고    scopus 로고
    • Lactate and force production in skeletal muscle
    • Kristensen, M.; Albertsen, J.; Rentsch, M.; Juel, C. Lactate and force production in skeletal muscle. J. Physiol. 2005, 562, 521–526. [CrossRef] [PubMed]
    • (2005) J. Physiol. , vol.562 , pp. 521-526
    • Kristensen, M.1    Albertsen, J.2    Rentsch, M.3    Juel, C.4
  • 19
    • 85016852457 scopus 로고    scopus 로고
    • Fructose alters intermediary metabolism of glucose in human adipocytes and diverts glucose to serine oxidation in the one-carbon cycle energy producing pathway
    • Varma, V.; Boros, L.G.; Nolen, G.T.; Chang, C.W.; Wabitsch, M.; Beger, R.D.; Kaput, J. Fructose alters intermediary metabolism of glucose in human adipocytes and diverts glucose to serine oxidation in the one-carbon cycle energy producing pathway. Metabolites 2015, 5, 364–385. [CrossRef] [PubMed]
    • (2015) Metabolites , vol.5 , pp. 364-385
    • Varma, V.1    Boros, L.G.2    Nolen, G.T.3    Chang, C.W.4    Wabitsch, M.5    Beger, R.D.6    Kaput, J.7
  • 20
    • 0026593475 scopus 로고
    • Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin
    • Lovejoy, J.; Newby, F.D.; Gebhart, S.S.; Digirolamo, M. Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin. Metab. Clin. Exp. 1992, 41, 22. [CrossRef]
    • (1992) Metab. Clin. Exp. , vol.41 , pp. 22
    • Lovejoy, J.1    Newby, F.D.2    Gebhart, S.S.3    Digirolamo, M.4
  • 21
    • 0036320908 scopus 로고    scopus 로고
    • Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling
    • Choi, C.S.; Kim, Y.B.; Lee, F.N.; Zabolotny, J.M.; Kahn, B.B.; Youn, J.H. Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling. Am. J. Physiol. Endocrinol. Metab. 2002, 283, E233–E240. [CrossRef] [PubMed]
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.283 , pp. E233-E240
    • Choi, C.S.1    Kim, Y.B.2    Lee, F.N.3    Zabolotny, J.M.4    Kahn, B.B.5    Youn, J.H.6
  • 22
    • 78650911575 scopus 로고    scopus 로고
    • Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice
    • Leite, T.C.; Coelho, R.G.; Da Silva, D.; Coelho, W.S.; Marinho-Carvalho, M.M.; Sola-Penna, M. Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice. FEBS Lett. 2011, 585, 92–98. [CrossRef] [PubMed]
    • (2011) FEBS Lett , vol.585 , pp. 92-98
    • Leite, T.C.1    Coelho, R.G.2    Da Silva, D.3    Coelho, W.S.4    Marinho-Carvalho, M.M.5    Sola-Penna, M.6
  • 24
    • 0030048269 scopus 로고    scopus 로고
    • Improvement of insulin action in diabetic transgenic mice selectively overexpressing GLUT4 in skeletal muscle
    • Leturque, A.; Loizeau, M.; Vaulont, S.; Salminen, M.; Girard, J. Improvement of insulin action in diabetic transgenic mice selectively overexpressing GLUT4 in skeletal muscle. Diabetes 1996, 45, 23–27. [CrossRef] [PubMed]
    • (1996) Diabetes , vol.45 , pp. 23-27
    • Leturque, A.1    Loizeau, M.2    Vaulont, S.3    Salminen, M.4    Girard, J.5
  • 25
    • 0024237258 scopus 로고
    • Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans
    • Baron, A.D.; Brechtel, G.; Wallace, P.; Edelman, S.V. Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am. J. Physiol. 1988, 255, E769–E774. [PubMed]
    • (1988) Am. J. Physiol. , vol.255 , pp. E769-E774
    • Baron, A.D.1    Brechtel, G.2    Wallace, P.3    Edelman, S.V.4
  • 27
    • 84867186423 scopus 로고    scopus 로고
    • Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess
    • Liu, J.; Zhang, W.; Chuang, G.C.; Hill, H.S.; Tian, L.; Fu, Y.; Moellering, D.R.; Garvey, W.T. Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess. Am. J. Physiol. Endocrinol. Metab. 2012, 303, E908–E916. [CrossRef] [PubMed]
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.303 , pp. E908-E916
    • Liu, J.1    Zhang, W.2    Chuang, G.C.3    Hill, H.S.4    Tian, L.5    Fu, Y.6    Moellering, D.R.7    Garvey, W.T.8
  • 28
    • 0036632631 scopus 로고    scopus 로고
    • Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings
    • Marette, A. Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings. Curr. Opin. Clin. Nutr. Metab. Care 2002, 5, 377. [CrossRef] [PubMed]
    • (2002) Curr. Opin. Clin. Nutr. Metab. Care , vol.5 , pp. 377
    • Marette, A.1
  • 29
    • 66449093225 scopus 로고    scopus 로고
    • Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
    • Stanhope, K.L.; Schwarz, J.M.; Keim, N.L.; Griffen, S.C.; Bremer, A.A.; Graham, J.L.; Hatcher, B.; Cox, C.L.; Dyachenko, A.; Zhang, W. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J. Clin. Investig. 2009, 119, 1322–1334. [CrossRef] [PubMed]
    • (2009) J. Clin. Investig. , vol.119 , pp. 1322-1334
    • Stanhope, K.L.1    Schwarz, J.M.2    Keim, N.L.3    Griffen, S.C.4    Bremer, A.A.5    Graham, J.L.6    Hatcher, B.7    Cox, C.L.8    Dyachenko, A.9    Zhang, W.10
  • 30
    • 84944930248 scopus 로고    scopus 로고
    • Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle
    • De Stefanis, D.; Mastrocola, R.; Nigro, D.; Costelli, P.; Aragno, M. Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle. Eur. J. Nutr. 2017, 56, 363–373. [CrossRef] [PubMed]
    • (2017) Eur. J. Nutr. , vol.56 , pp. 363-373
    • De Stefanis, D.1    Mastrocola, R.2    Nigro, D.3    Costelli, P.4    Aragno, M.5
  • 31
    • 84889068833 scopus 로고    scopus 로고
    • Cardiac dysfunction in rats with dietary-induced insulin resistance associated with pharmacologically-induced dyslipidemia
    • Tanguy, S.; Toufektsian, M.C.; Grauzam, S.; de Leiris, J.; Ghezzi, C.; Boucher, F.; Sulpice, T. Cardiac dysfunction in rats with dietary-induced insulin resistance associated with pharmacologically-induced dyslipidemia. Curr. Pharm. Des. 2013, 19, 6906–6911. [CrossRef] [PubMed]
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 6906-6911
    • Tanguy, S.1    Toufektsian, M.C.2    Grauzam, S.3    De Leiris, J.4    Ghezzi, C.5    Boucher, F.6    Sulpice, T.7
  • 32
    • 84944566005 scopus 로고    scopus 로고
    • Fructose-enriched diet induces inflammation and reduces antioxidative defense in visceral adipose tissue of young female rats
    • Kovacevic, S.; Nestorov, J.; Matic, G.; Elakovic, I. Fructose-enriched diet induces inflammation and reduces antioxidative defense in visceral adipose tissue of young female rats. Eur. J. Nutr. 2017, 56, 151–160. [CrossRef] [PubMed]
    • (2017) Eur. J. Nutr. , vol.56 , pp. 151-160
    • Kovacevic, S.1    Nestorov, J.2    Matic, G.3    Elakovic, I.4
  • 33
    • 84923997910 scopus 로고    scopus 로고
    • Sweet debate: Fructose versus glucose in diabetic kidney disease
    • Beckerman, P.; Susztak, K. Sweet debate: Fructose versus glucose in diabetic kidney disease. J. Am. Soc. Nephrol. 2014, 25, 2386–2388. [CrossRef] [PubMed]
    • (2014) J. Am. Soc. Nephrol. , vol.25 , pp. 2386-2388
    • Beckerman, P.1    Susztak, K.2
  • 37
    • 85030973423 scopus 로고    scopus 로고
    • Docosapentaenoic acid and docosahexaenoic acid are positively associated with insulin sensitivity in rats fed high-fat and high-fructose diets
    • Huang, J.P.; Cheng, M.L.; Hung, C.Y.; Wang, C.H.; Hsieh, P.S.; Shiao, M.S.; Chen, J.K.; Li, D.E.; Hung, L.M. Docosapentaenoic acid and docosahexaenoic acid are positively associated with insulin sensitivity in rats fed high-fat and high-fructose diets. J. Diabetes 2016. [CrossRef] [PubMed]
    • (2016) J. Diabetes
    • Huang, J.P.1    Cheng, M.L.2    Hung, C.Y.3    Wang, C.H.4    Hsieh, P.S.5    Shiao, M.S.6    Chen, J.K.7    Li, D.E.8    Hung, L.M.9
  • 39
    • 0033779714 scopus 로고    scopus 로고
    • Free fatty acids and pathogenesis of type 2 diabetes mellitus
    • Bergman, R.N.; Ader, M. Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol. Metab. 2000, 11, 351–356. [CrossRef]
    • (2000) Trends Endocrinol. Metab. , vol.11 , pp. 351-356
    • Bergman, R.N.1    Ader, M.2
  • 40
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu, H.; Barnes, G.T.; Yang, Q.; Tan, G.; Yang, D.; Chou, C.J.; Sole, J.; Nichols, A.; Ross, J.S.; Tartaglia, L.A.; et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Investig. 2003, 112, 1821–1830. [CrossRef] [PubMed]
    • (2003) J. Clin. Investig , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3    Tan, G.4    Yang, D.5    Chou, C.J.6    Sole, J.7    Nichols, A.8    Ross, J.S.9    Tartaglia, L.A.10
  • 41
    • 58149401189 scopus 로고    scopus 로고
    • Paradoxical effects of increased expression of pgc-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
    • Choi, C.S.; Befroy, D.E.; Codella, R.; Kim, S.; Reznick, R.M.; Hwang, Y.J.; Liu, Z.X.; Lee, H.Y.; Distefano, A.; Samuel, V.T.; et al. Paradoxical effects of increased expression of pgc-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc. Natl. Acad. Sci. USA 2008, 105, 19926–19931. [CrossRef] [PubMed]
    • (2008) Proc. Natl. Acad. Sci. , vol.105 , pp. 19926-19931
    • Choi, C.S.1    Befroy, D.E.2    Codella, R.3    Kim, S.4    Reznick, R.M.5    Hwang, Y.J.6    Liu, Z.X.7    Lee, H.Y.8    Distefano, A.9    Samuel, V.T.10
  • 42
    • 77951427605 scopus 로고    scopus 로고
    • Curcumin inhibits hepatic protein-tyrosine phosphatase 1b and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats
    • Li, J.M.; Li, Y.C.; Kong, L.D.; Hu, Q.H. Curcumin inhibits hepatic protein-tyrosine phosphatase 1b and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatology 2010, 51, 1555–1566. [CrossRef] [PubMed]
    • (2010) Hepatology , vol.51 , pp. 1555-1566
    • Li, J.M.1    Li, Y.C.2    Kong, L.D.3    Hu, Q.H.4
  • 43
    • 0036315888 scopus 로고    scopus 로고
    • Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
    • Lupi, R.; Dotta, F.; Marselli, L.; Del, G.S.; Masini, M.; Santangelo, C.; Patane, G.; Boggi, U.; Piro, S.; Anello, M. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 2002, 51, 1437–1442. [CrossRef] [PubMed]
    • (2002) Diabetes , vol.51 , pp. 1437-1442
    • Lupi, R.1    Dotta, F.2    Marselli, L.3    Del, G.S.4    Masini, M.5    Santangelo, C.6    Patane, G.7    Boggi, U.8    Piro, S.9    Anello, M.10
  • 44
    • 52749087214 scopus 로고    scopus 로고
    • Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets
    • Kato, T.; Shimano, H.; Yamamoto, T.; Ishikawa, M.; Kumadaki, S.; Matsuzaka, T.; Nakagawa, Y.; Yahagi, N.; Nakakuki, M.; Hasty, A.H.; et al. Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets. Diabetes 2008, 57, 2382–2392. [CrossRef] [PubMed]
    • (2008) Diabetes , vol.57 , pp. 2382-2392
    • Kato, T.1    Shimano, H.2    Yamamoto, T.3    Ishikawa, M.4    Kumadaki, S.5    Matsuzaka, T.6    Nakagawa, Y.7    Yahagi, N.8    Nakakuki, M.9    Hasty, A.H.10
  • 45
    • 0034522296 scopus 로고    scopus 로고
    • Fatty acids and insulin secretion
    • Amery, C.M.; Nattrass, M. Fatty acids and insulin secretion. Br. J. Nutr. 2000, 2, 213. [CrossRef]
    • (2000) Br. J. Nutr. , vol.2 , pp. 213
    • Amery, C.M.1    Nattrass, M.2
  • 46
    • 85016446703 scopus 로고    scopus 로고
    • Interleukin-22 restored mitochondrial damage and impaired glucose-stimulated insulin secretion through down-regulation of uncoupling protein-2 in INS-1 cells
    • Hu, M.; Lin, H.; Yang, L.; Cheng, Y.; Zhang, H. Interleukin-22 restored mitochondrial damage and impaired glucose-stimulated insulin secretion through down-regulation of uncoupling protein-2 in INS-1 cells. J. Biochem. 2017. [CrossRef] [PubMed]
    • (2017) J. Biochem.
    • Hu, M.1    Lin, H.2    Yang, L.3    Cheng, Y.4    Zhang, H.5
  • 47
    • 84930515860 scopus 로고    scopus 로고
    • Antagonism between saturated and unsaturated fatty acids in ros mediated lipotoxicity in rat insulin-producing cells. Cell. Physiol
    • Gehrmann, W.; Würdemann, W.; Plötz, T.; Jörns, A.; Lenzen, S.; Elsner, M. Antagonism between saturated and unsaturated fatty acids in ros mediated lipotoxicity in rat insulin-producing cells. Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol. 2015, 36, 852–865. [CrossRef] [PubMed]
    • (2015) Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol , vol.36 , pp. 852-865
    • Gehrmann, W.1    Würdemann, W.2    Plötz, T.3    Jörns, A.4    Lenzen, S.5    Elsner, M.6
  • 48
    • 84863022790 scopus 로고    scopus 로고
    • Cell death-inducing DFF45-like effector b (Cideb) is present in pancreatic beta-cells and involved in palmitate induced beta-cell apoptosis
    • Li, H.; Song, Y.; Zhang, L.J.; Li, F.F.; Gu, Y.; Zhang, J.; Dong, W.P.; Xue, L.; Zhang, L.Y.; Liu, F. Cell death-inducing DFF45-like effector b (Cideb) is present in pancreatic beta-cells and involved in palmitate induced beta-cell apoptosis. Diabetes/Metab. Res. Rev. 2012, 28, 145–155. [CrossRef] [PubMed]
    • (2012) Diabetes/Metab. Res. Rev. , vol.28 , pp. 145-155
    • Li, H.1    Song, Y.2    Zhang, L.J.3    Li, F.F.4    Gu, Y.5    Zhang, J.6    Dong, W.P.7    Xue, L.8    Zhang, L.Y.9    Liu, F.10
  • 49
    • 84894033378 scopus 로고    scopus 로고
    • The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in βTC6 cells
    • Shen, X.; Yang, L.; Yan, S.; Wei, W.; Liang, L.; Zheng, H.; Cai, X. The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in βTC6 cells. Metab. Clin. Exp. 2013, 63, 335–351. [CrossRef] [PubMed]
    • (2013) Metab. Clin. Exp. , vol.63 , pp. 335-351
    • Shen, X.1    Yang, L.2    Yan, S.3    Wei, W.4    Liang, L.5    Zheng, H.6    Cai, X.7
  • 50
    • 84944393898 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition ameliorates western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function
    • Aroor, A.R.; Habibi, J.; Ford, D.A.; Nistala, R.; Lastra, G.; Manrique, C.; Dunham, M.M.; Ford, K.D.; Thyfault, J.P.; Parks, E.J.; et al. Dipeptidyl peptidase-4 inhibition ameliorates western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function. Diabetes 2015, 64, 1988–2001. [CrossRef] [PubMed]
    • (2015) Diabetes , vol.64 , pp. 1988-2001
    • Aroor, A.R.1    Habibi, J.2    Ford, D.A.3    Nistala, R.4    Lastra, G.5    Manrique, C.6    Dunham, M.M.7    Ford, K.D.8    Thyfault, J.P.9    Parks, E.J.10
  • 51
    • 56149125083 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism
    • Vila, L.; Roglans, N.; Alegret, M.; Sánchez, R.M.; Vázquez-Carrera, M.; Laguna, J.C. Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism. Hepatology 2008, 48, 1506–1516. [CrossRef] [PubMed]
    • (2008) Hepatology , vol.48 , pp. 1506-1516
    • Vila, L.1    Roglans, N.2    Alegret, M.3    Sánchez, R.M.4    Vázquez-Carrera, M.5    Laguna, J.C.6
  • 52
    • 0028950335 scopus 로고
    • Tissue-dependent activation of protein kinase c in fructose-induced insulin resistance
    • Donnelly, R.; Chang, H.; Azhar, S.; Reaven, G.M. Tissue-dependent activation of protein kinase c in fructose-induced insulin resistance. Endocrine 1995, 3, 129–133. [CrossRef] [PubMed]
    • (1995) Endocrine , vol.3 , pp. 129-133
    • Donnelly, R.1    Chang, H.2    Azhar, S.3    Reaven, G.M.4
  • 53
    • 60649109153 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance
    • Nagai, Y.; Yonemitsu, S.; Erion, D.M.; Iwasaki, T.; Stark, R.; Weismann, D.; Dong, J.; Zhang, D.; Jurczak, M.J.; Loffler, M.G.; et al. The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. Cell Metab. 2009, 9, 252–264. [CrossRef] [PubMed]
    • (2009) Cell Metab , vol.9 , pp. 252-264
    • Nagai, Y.1    Yonemitsu, S.2    Erion, D.M.3    Iwasaki, T.4    Stark, R.5    Weismann, D.6    Dong, J.7    Zhang, D.8    Jurczak, M.J.9    Loffler, M.G.10
  • 55
    • 0029060391 scopus 로고
    • Protein kinase c and lipid signaling for sustained cellular responses
    • Nishizuka, Y. Protein kinase c and lipid signaling for sustained cellular responses. FASEB J. 1995, 9, 484–496. [PubMed]
    • (1995) FASEB J , vol.9 , pp. 484-496
    • Nishizuka, Y.1
  • 56
    • 84860497397 scopus 로고    scopus 로고
    • Diacylglycerol activation of protein kinase cepsilon and hepatic insulin resistance
    • Jornayvaz, F.R.; Shulman, G.I. Diacylglycerol activation of protein kinase cepsilon and hepatic insulin resistance. Cell Metab. 2012, 15, 574–584. [CrossRef] [PubMed]
    • (2012) Cell Metab , vol.15 , pp. 574-584
    • Jornayvaz, F.R.1    Shulman, G.I.2
  • 57
    • 84881163357 scopus 로고    scopus 로고
    • Plasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a western-style diet
    • Brozinick, J.T.; Hawkins, E.; Hoang Bui, H.; Kuo, M.S.; Tan, B.; Kievit, P.; Grove, K. Plasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a western-style diet. Int. J. Obes. 2013, 37, 1064–1070. [CrossRef] [PubMed]
    • (2013) Int. J. Obes. , vol.37 , pp. 1064-1070
    • Brozinick, J.T.1    Hawkins, E.2    Hoang Bui, H.3    Kuo, M.S.4    Tan, B.5    Kievit, P.6    Grove, K.7
  • 58
    • 84876803025 scopus 로고    scopus 로고
    • Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: Evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction
    • Dekker, M.J.; Baker, C.; Naples, M.; Samsoondar, J.; Zhang, R.; Qiu, W.; Sacco, J.; Adeli, K. Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: Evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction. Atherosclerosis 2013, 228, 98–109. [CrossRef] [PubMed]
    • (2013) Atherosclerosis , vol.228 , pp. 98-109
    • Dekker, M.J.1    Baker, C.2    Naples, M.3    Samsoondar, J.4    Zhang, R.5    Qiu, W.6    Sacco, J.7    Adeli, K.8
  • 59
    • 84888385693 scopus 로고    scopus 로고
    • Increased skeletal muscle mitochondrial efficiency in rats with fructose-induced alteration in glucose tolerance
    • Crescenzo, R.; Bianco, F.; Coppola, P.; Mazzoli, A.; Cigliano, L.; Liverini, G.; Iossa, S. Increased skeletal muscle mitochondrial efficiency in rats with fructose-induced alteration in glucose tolerance. Br. J. Nutr. 2013, 110, 1996–2003. [CrossRef] [PubMed]
    • (2013) Br. J. Nutr. , vol.110 , pp. 1996-2003
    • Crescenzo, R.1    Bianco, F.2    Coppola, P.3    Mazzoli, A.4    Cigliano, L.5    Liverini, G.6    Iossa, S.7
  • 60
    • 0036142812 scopus 로고    scopus 로고
    • Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation
    • Kralik, S.F.; Liu, P.; Leffler, B.J.; Elmendorf, J.S. Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation. Endocrinology 2002, 143, 37–46. [CrossRef] [PubMed]
    • (2002) Endocrinology , vol.143 , pp. 37-46
    • Kralik, S.F.1    Liu, P.2    Leffler, B.J.3    Elmendorf, J.S.4
  • 61
    • 84888875869 scopus 로고    scopus 로고
    • Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway
    • Wang, X.; Zhang, D.M.; Gu, T.T.; Ding, X.Q.; Fan, C.Y.; Zhu, Q.; Shi, Y.W.; Hong, Y.; Kong, L.D. Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. Biochem. Pharmacol. 2013, 86, 1791. [CrossRef] [PubMed]
    • (2013) Biochem. Pharmacol. , vol.86 , pp. 1791
    • Wang, X.1    Zhang, D.M.2    Gu, T.T.3    Ding, X.Q.4    Fan, C.Y.5    Zhu, Q.6    Shi, Y.W.7    Hong, Y.8    Kong, L.D.9
  • 62
    • 84908333551 scopus 로고    scopus 로고
    • Fructose supplementation worsens the deleterious effects of short-term high-fat feeding on hepatic steatosis and lipid metabolism in adult rats
    • Crescenzo, R.; Bianco, F.; Coppola, P.; Mazzoli, A.; Tussellino, M.; Carotenuto, R.; Liverini, G.; Iossa, S. Fructose supplementation worsens the deleterious effects of short-term high-fat feeding on hepatic steatosis and lipid metabolism in adult rats. Exp. Physiol. 2014, 99, 1203–1213. [CrossRef] [PubMed]
    • (2014) Exp. Physiol. , vol.99 , pp. 1203-1213
    • Crescenzo, R.1    Bianco, F.2    Coppola, P.3    Mazzoli, A.4    Tussellino, M.5    Carotenuto, R.6    Liverini, G.7    Iossa, S.8
  • 63
    • 84879550625 scopus 로고    scopus 로고
    • Increased hepatic de novo lipogenesis and mitochondrial efficiency in a model of obesity induced by diets rich in fructose
    • Crescenzo, R.; Bianco, F.; Falcone, I.; Coppola, P.; Liverini, G.; Iossa, S. Increased hepatic de novo lipogenesis and mitochondrial efficiency in a model of obesity induced by diets rich in fructose. Eur. J. Nutr. 2013, 52, 537–545. [CrossRef] [PubMed]
    • (2013) Eur. J. Nutr. , vol.52 , pp. 537-545
    • Crescenzo, R.1    Bianco, F.2    Falcone, I.3    Coppola, P.4    Liverini, G.5    Iossa, S.6
  • 64
    • 84930182595 scopus 로고    scopus 로고
    • Fructose induces mitochondrial dysfunction and triggers apoptosis in skeletal muscle cells by provoking oxidative stress
    • Jaiswal, N.; Maurya, C.K.; Arha, D.; Avisetti, D.R.; Prathapan, A.; Raj, P.S.; Raghu, K.G.; Kalivendi, S.V.; Tamrakar, A.K. Fructose induces mitochondrial dysfunction and triggers apoptosis in skeletal muscle cells by provoking oxidative stress. Apoptosis 2015, 20, 930–947. [CrossRef] [PubMed]
    • (2015) Apoptosis , vol.20 , pp. 930-947
    • Jaiswal, N.1    Maurya, C.K.2    Arha, D.3    Avisetti, D.R.4    Prathapan, A.5    Raj, P.S.6    Raghu, K.G.7    Kalivendi, S.V.8    Tamrakar, A.K.9
  • 66
    • 84938093088 scopus 로고    scopus 로고
    • Hepatocyte nicotinamide adenine dinucleotide phosphate reduced oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice
    • Bettaieb, A.; Jiang, J.X.; Sasaki, Y.; Chao, T.I.; Kiss, Z.; Chen, X.; Tian, J.; Katsuyama, M.; Yabe-Nishimura, C.; Xi, Y.; et al. Hepatocyte nicotinamide adenine dinucleotide phosphate reduced oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice. Gastroenterology 2015, 149, 468–480. [CrossRef] [PubMed]
    • (2015) Gastroenterology , vol.149 , pp. 468-480
    • Bettaieb, A.1    Jiang, J.X.2    Sasaki, Y.3    Chao, T.I.4    Kiss, Z.5    Chen, X.6    Tian, J.7    Katsuyama, M.8    Yabe-Nishimura, C.9    Xi, Y.10
  • 67
    • 84974622946 scopus 로고    scopus 로고
    • Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation
    • Kang, L.L.; Zhang, D.M.; Ma, C.H.; Zhang, J.H.; Jia, K.K.; Liu, J.H.; Wang, R.; Kong, L.D. Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation. Sci. Rep. 2016, 6, 27460. [CrossRef] [PubMed]
    • (2016) Sci. Rep. , vol.6
    • Kang, L.L.1    Zhang, D.M.2    Ma, C.H.3    Zhang, J.H.4    Jia, K.K.5    Liu, J.H.6    Wang, R.7    Kong, L.D.8
  • 68
    • 84894472601 scopus 로고    scopus 로고
    • Caffeine intake improves fructose-induced hypertension and insulin resistance by enhancing central insulin signaling
    • Yeh, T.C.; Liu, C.P.; Cheng, W.H.; Chen, B.R.; Lu, P.J.; Cheng, P.W.; Ho, W.Y.; Sun, G.C.; Liou, J.C.; Tseng, C.J. Caffeine intake improves fructose-induced hypertension and insulin resistance by enhancing central insulin signaling. Hypertension 2014, 63, 535–541. [CrossRef] [PubMed]
    • (2014) Hypertension , vol.63 , pp. 535-541
    • Yeh, T.C.1    Liu, C.P.2    Cheng, W.H.3    Chen, B.R.4    Lu, P.J.5    Cheng, P.W.6    Ho, W.Y.7    Sun, G.C.8    Liou, J.C.9    Tseng, C.J.10
  • 70
    • 84996490565 scopus 로고    scopus 로고
    • Liquid fructose in western-diet-fed mice impairs liver insulin signaling and causes cholesterol and triglyceride loading without changing calorie intake and body weight
    • Baena, M.; Sanguesa, G.; Hutter, N.; Beltran, J.M.; Sanchez, R.M.; Roglans, N.; Alegret, M.; Laguna, J.C. Liquid fructose in western-diet-fed mice impairs liver insulin signaling and causes cholesterol and triglyceride loading without changing calorie intake and body weight. J. Nutr. Biochem. 2017, 40, 105–115. [CrossRef] [PubMed]
    • (2017) J. Nutr. Biochem. , vol.40 , pp. 105-115
    • Baena, M.1    Sanguesa, G.2    Hutter, N.3    Beltran, J.M.4    Sanchez, R.M.5    Roglans, N.6    Alegret, M.7    Laguna, J.C.8
  • 71
    • 84965084999 scopus 로고    scopus 로고
    • Mitigation of insulin resistance by mangiferin in a rat model of fructose-induced metabolic syndrome is associated with modulation of CD36 redistribution in the skeletal muscle
    • Zhou, L.; Pan, Y.; Chonan, R.; Batey, R.; Rong, X.; Yamahara, J.; Wang, J.; Li, Y. Mitigation of insulin resistance by mangiferin in a rat model of fructose-induced metabolic syndrome is associated with modulation of CD36 redistribution in the skeletal muscle. J. Pharmacol. Exp. Ther. 2016, 356, 74–84. [CrossRef] [PubMed]
    • (2016) J. Pharmacol. Exp. Ther. , vol.356 , pp. 74-84
    • Zhou, L.1    Pan, Y.2    Chonan, R.3    Batey, R.4    Rong, X.5    Yamahara, J.6    Wang, J.7    Li, Y.8
  • 72
    • 85008599086 scopus 로고    scopus 로고
    • Specific regions of the brain are capable of fructose metabolism
    • Oppelt, S.A.; Zhang, W.; Tolan, D.R. Specific regions of the brain are capable of fructose metabolism. Brain Res. 2017, 1657, 312–322. [CrossRef] [PubMed]
    • (2017) Brain Res , vol.1657 , pp. 312-322
    • Oppelt, S.A.1    Zhang, W.2    Tolan, D.R.3
  • 73
    • 36649006484 scopus 로고    scopus 로고
    • New insights into the roles of proteins and lipids in membrane transport of fatty acids
    • Hamilton, J.A. New insights into the roles of proteins and lipids in membrane transport of fatty acids. Prostaglandins Leukot. Essent. Fat. Acids 2007, 77, 355–361. [CrossRef] [PubMed]
    • (2007) Prostaglandins Leukot. Essent. Fat. Acids , vol.77 , pp. 355-361
    • Hamilton, J.A.1
  • 74
    • 0015814618 scopus 로고
    • Influences of hepatic portal receptors on hypothalamic feeding and satiety centers
    • Schmitt, M. Influences of hepatic portal receptors on hypothalamic feeding and satiety centers. Am. J. Physiol. 1973, 225, 1089–1095. [PubMed]
    • (1973) Am. J. Physiol. , vol.225 , pp. 1089-1095
    • Schmitt, M.1
  • 75
    • 0015835119 scopus 로고
    • Depletion of liver adenosine phosphates and metabolic effects of intravenous infusion of fructose or sorbitol in man and in the rat
    • Bode, J.C.; Zelder, O.; Rumpelt, H.J.; Wittkamp, U. Depletion of liver adenosine phosphates and metabolic effects of intravenous infusion of fructose or sorbitol in man and in the rat. Eur J. Clin. Investig. 1973, 3, 436–441. [CrossRef]
    • (1973) Eur J. Clin. Investig. , vol.3 , pp. 436-441
    • Bode, J.C.1    Zelder, O.2    Rumpelt, H.J.3    Wittkamp, U.4
  • 76
    • 79955876506 scopus 로고    scopus 로고
    • Role of tumor necrosis factor alpha (TNFalpha) in the onset of fructose-induced nonalcoholic fatty liver disease in mice
    • Kanuri, G.; Spruss, A.; Wagnerberger, S.; Bischoff, S.C.; Bergheim, I. Role of tumor necrosis factor alpha (TNFalpha) in the onset of fructose-induced nonalcoholic fatty liver disease in mice. J. Nutr. Biochem. 2011, 22, 527–534. [CrossRef] [PubMed]
    • (2011) J. Nutr. Biochem. , vol.22 , pp. 527-534
    • Kanuri, G.1    Spruss, A.2    Wagnerberger, S.3    Bischoff, S.C.4    Bergheim, I.5
  • 77
    • 55949086381 scopus 로고    scopus 로고
    • Differential effects of central fructose and glucose on hypothalamic malonyl-coa and food intake
    • Cha, S.H.; Wolfgang, M.; Tokutake, Y.; Chohnan, S.; Lane, M.D. Differential effects of central fructose and glucose on hypothalamic malonyl-coa and food intake. Proc. Natl. Acad. Sci. USA 2008, 105, 16871–16875. [CrossRef] [PubMed]
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 16871-16875
    • Cha, S.H.1    Wolfgang, M.2    Tokutake, Y.3    Chohnan, S.4    Lane, M.D.5
  • 79
    • 84880575747 scopus 로고    scopus 로고
    • Resolved: There is sufficient scientific evidence that decreasing sugar-sweetened beverage consumption will reduce the prevalence of obesity and obesity-related diseases
    • Hu, F.B. Resolved: There is sufficient scientific evidence that decreasing sugar-sweetened beverage consumption will reduce the prevalence of obesity and obesity-related diseases. Obes. Rev. Off. J. Int. Assoc. Stud. Obes. 2013, 14, 606–619. [CrossRef] [PubMed]
    • (2013) Obes. Rev. Off. J. Int. Assoc. Stud. Obes. , vol.14 , pp. 606-619
    • Hu, F.B.1
  • 80
    • 70350131993 scopus 로고    scopus 로고
    • Replacing dietary glucose with fructose increases chrebp activity and SREBP-1 protein in rat liver nucleus
    • Koo, H.Y.; Miyashita, M.; Cho, B.H.; Nakamura, M.T. Replacing dietary glucose with fructose increases chrebp activity and SREBP-1 protein in rat liver nucleus. Biochem. Biophys. Res. Commun. 2009, 390, 285–289. [CrossRef] [PubMed]
    • (2009) Biochem. Biophys. Res. Commun. , vol.390 , pp. 285-289
    • Koo, H.Y.1    Miyashita, M.2    Cho, B.H.3    Nakamura, M.T.4
  • 81
    • 84922575455 scopus 로고    scopus 로고
    • High-fructose feeding promotes accelerated degradation of hepatic LDL receptor and hypercholesterolemia in hamsters via elevated circulating PCSK9 levels
    • Dong, B.; Singh, A.B.; Azhar, S.; Seidah, N.G.; Liu, J. High-fructose feeding promotes accelerated degradation of hepatic LDL receptor and hypercholesterolemia in hamsters via elevated circulating PCSK9 levels. Atherosclerosis 2015, 239, 364–374. [CrossRef] [PubMed]
    • (2015) Atherosclerosis , vol.239 , pp. 364-374
    • Dong, B.1    Singh, A.B.2    Azhar, S.3    Seidah, N.G.4    Liu, J.5
  • 82
    • 85016517399 scopus 로고
    • Biochemical mechanism of hypercholesterolemia-induced atherosclerosis
    • Prasad, K.; Kalra, J. Biochemical mechanism of hypercholesterolemia-induced atherosclerosis. Clin. Biochem. 1993, 26, 128. [CrossRef]
    • (1993) Clin. Biochem. , vol.26 , pp. 128
    • Prasad, K.1    Kalra, J.2
  • 83
    • 0023870107 scopus 로고
    • Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster
    • Spady, D.K.; Dietschy, J.M. Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster. J. Clin. Investig. 1988, 81, 300–309. [CrossRef] [PubMed]
    • (1988) J. Clin. Investig. , vol.81 , pp. 300-309
    • Spady, D.K.1    Dietschy, J.M.2
  • 84
    • 84930419045 scopus 로고    scopus 로고
    • A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults
    • Stanhope, K.L.; Medici, V.; Bremer, A.A.; Lee, V.; Lam, H.D.; Nunez, M.V.; Chen, G.X.; Keim, N.L.; Havel, P.J. A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults. Am. J. Clin. Nutr. 2015, 101, 1144. [CrossRef] [PubMed]
    • (2015) Am. J. Clin. Nutr. , vol.101 , pp. 1144
    • Stanhope, K.L.1    Medici, V.2    Bremer, A.A.3    Lee, V.4    Lam, H.D.5    Nunez, M.V.6    Chen, G.X.7    Keim, N.L.8    Havel, P.J.9
  • 86
    • 51649087722 scopus 로고    scopus 로고
    • Triglyceride-rich lipoprotein-associated apolipoprotein c-iii production is stimulated by plasma free fatty acids in humans
    • Pavlic, M.; Valero, R.; Duez, H.; Xiao, C.; Szeto, L.; Patterson, B.W.; Lewis, G.F. Triglyceride-rich lipoprotein-associated apolipoprotein c-iii production is stimulated by plasma free fatty acids in humans. Arterioscler. Thromb. Vasc. Biol. 2008, 28, 1660–1665. [CrossRef] [PubMed]
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 1660-1665
    • Pavlic, M.1    Valero, R.2    Duez, H.3    Xiao, C.4    Szeto, L.5    Patterson, B.W.6    Lewis, G.F.7
  • 87
    • 0032484117 scopus 로고    scopus 로고
    • Liver-specific overexpression of scavenger receptor BI decreases levels of very low density lipoprotein ApoB, low density lipoprotein ApoB, and high density lipoprotein in transgenic mice
    • Wang, N.; Arai, T.; Ji, Y.; Rinninger, F.; Tall, A.R. Liver-specific overexpression of scavenger receptor BI decreases levels of very low density lipoprotein ApoB, low density lipoprotein ApoB, and high density lipoprotein in transgenic mice. J. Biol. Chem. 1998, 273, 32920–32926. [CrossRef] [PubMed]
    • (1998) J. Biol. Chem. , vol.273 , pp. 32920-32926
    • Wang, N.1    Arai, T.2    Ji, Y.3    Rinninger, F.4    Tall, A.R.5
  • 88
    • 84940753794 scopus 로고    scopus 로고
    • Intestinal scavenger receptor class b type i as a novel regulator of chylomicron production in healthy and diet-induced obese states
    • Lino, M.; Farr, S.; Baker, C.; Fuller, M.; Trigatti, B.; Adeli, K. Intestinal scavenger receptor class b type i as a novel regulator of chylomicron production in healthy and diet-induced obese states. Am. J. Physiol. Gastrointest. Liver Physiol. 2015, 309, G350–G359. [CrossRef] [PubMed]
    • (2015) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.309 , pp. G350-G359
    • Lino, M.1    Farr, S.2    Baker, C.3    Fuller, M.4    Trigatti, B.5    Adeli, K.6
  • 90
    • 33646338312 scopus 로고    scopus 로고
    • Hypothesis: Fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome
    • Nakagawa, T.; Tuttle, K.R.; Short, R.A.; Johnson, R.J. Hypothesis: Fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome. Nat. Clin. Pract. Nephrol. 2005, 1, 80. [CrossRef] [PubMed]
    • (2005) Nat. Clin. Pract. Nephrol. , vol.1 , pp. 80
    • Nakagawa, T.1    Tuttle, K.R.2    Short, R.A.3    Johnson, R.J.4
  • 92
    • 84869996114 scopus 로고    scopus 로고
    • Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: Potential role in fructose-dependent and -independent fatty liver
    • Lanaspa, M.A.; Sanchez-Lozada, L.G.; Choi, Y.J.; Cicerchi, C.; Kanbay, M.; Roncal-Jimenez, C.A.; Ishimoto, T.; Li, N.; Marek, G.; Duranay, M.; et al. Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: Potential role in fructose-dependent and -independent fatty liver. J. Biol. Chem. 2012, 287, 40732–40744. [CrossRef] [PubMed]
    • (2012) J. Biol. Chem. , vol.287 , pp. 40732-40744
    • Lanaspa, M.A.1    Sanchez-Lozada, L.G.2    Choi, Y.J.3    Cicerchi, C.4    Kanbay, M.5    Roncal-Jimenez, C.A.6    Ishimoto, T.7    Li, N.8    Marek, G.9    Duranay, M.10
  • 93
    • 34547733397 scopus 로고    scopus 로고
    • Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress
    • Sautin, Y.Y.; Nakagawa, T.; Zharikov, S.; Johnson, R.J. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am. J. Physiol. Cell Physiol. 2007, 293, C584–C596. [CrossRef] [PubMed]
    • (2007) Am. J. Physiol. Cell Physiol. , vol.293 , pp. C584-C596
    • Sautin, Y.Y.1    Nakagawa, T.2    Zharikov, S.3    Johnson, R.J.4
  • 94
    • 84964299212 scopus 로고    scopus 로고
    • Uric acid and transforming growth factor in fructose-induced production of reactive oxygen species in skeletal muscle
    • Madlala, H.P.; Maarman, G.J.; Ojuka, E. Uric acid and transforming growth factor in fructose-induced production of reactive oxygen species in skeletal muscle. Nutr. Rev. 2016, 74, 259–266. [CrossRef] [PubMed]
    • (2016) Nutr. Rev. , vol.74 , pp. 259-266
    • Madlala, H.P.1    Maarman, G.J.2    Ojuka, E.3
  • 96
    • 84998880879 scopus 로고    scopus 로고
    • High fructose causes cardiac hypertrophy via mitochondrial signaling pathway
    • Zhang, Y.B.; Meng, Y.H.; Chang, S.; Zhang, R.Y.; Shi, C. High fructose causes cardiac hypertrophy via mitochondrial signaling pathway. Am. J. Transl. Res. 2016, 8, 4869–4880. [PubMed]
    • (2016) Am. J. Transl. Res. , vol.8 , pp. 4869-4880
    • Zhang, Y.B.1    Meng, Y.H.2    Chang, S.3    Zhang, R.Y.4    Shi, C.5
  • 97
    • 84928035214 scopus 로고    scopus 로고
    • Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microrna-377
    • Wang, W.; Ding, X.Q.; Gu, T.T.; Song, L.; Li, J.M.; Xue, Q.C.; Kong, L.D. Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microrna-377. Free Radic. Biol. Med. 2015, 83, 214–226. [CrossRef] [PubMed]
    • (2015) Free Radic. Biol. Med. , vol.83 , pp. 214-226
    • Wang, W.1    Ding, X.Q.2    Gu, T.T.3    Song, L.4    Li, J.M.5    Xue, Q.C.6    Kong, L.D.7
  • 98
    • 84869875563 scopus 로고    scopus 로고
    • Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice
    • Chen, L.; Lan, Z.; Lin, Q.; Mi, X.; He, Y.; Wei, L.; Lin, Y.; Zhang, Y.; Deng, X. Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice. Food Chem. Toxicol. 2013, 52, 28–35. [CrossRef] [PubMed]
    • (2013) Food Chem. Toxicol. , vol.52 , pp. 28-35
    • Chen, L.1    Lan, Z.2    Lin, Q.3    Mi, X.4    He, Y.5    Wei, L.6    Lin, Y.7    Zhang, Y.8    Deng, X.9
  • 99
    • 80052032667 scopus 로고    scopus 로고
    • Genistein modulates nf-kappab-associated renal inflammation, fibrosis and podocyte abnormalities in fructose-fed rats
    • Palanisamy, N.; Kannappan, S.; Anuradha, C.V. Genistein modulates nf-kappab-associated renal inflammation, fibrosis and podocyte abnormalities in fructose-fed rats. Eur. J. Pharmacol. 2011, 667, 355–364. [CrossRef] [PubMed]
    • (2011) Eur. J. Pharmacol. , vol.667 , pp. 355-364
    • Palanisamy, N.1    Kannappan, S.2    Anuradha, C.V.3
  • 101
    • 84860681550 scopus 로고    scopus 로고
    • Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats
    • Hu, Q.H.; Zhang, X.; Pan, Y.; Li, Y.C.; Kong, L.D. Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats. Biochem. Pharmacol. 2012, 84, 113–125. [CrossRef] [PubMed]
    • (2012) Biochem. Pharmacol. , vol.84 , pp. 113-125
    • Hu, Q.H.1    Zhang, X.2    Pan, Y.3    Li, Y.C.4    Kong, L.D.5
  • 102
    • 84952976765 scopus 로고    scopus 로고
    • Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats. Eur
    • Ge, C.X.; Yu, R.; Xu, M.X.; Li, P.Q.; Fan, C.Y.; Li, J.M.; Kong, L.D. Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats. Eur. J. Pharmacol. 2015, 770, 154–164. [CrossRef] [PubMed]
    • (2015) J. Pharmacol , vol.770 , pp. 154-164
    • Ge, C.X.1    Yu, R.2    Xu, M.X.3    Li, P.Q.4    Fan, C.Y.5    Li, J.M.6    Kong, L.D.7
  • 103
    • 84895922899 scopus 로고    scopus 로고
    • Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats
    • Zhang, Q.Y.; Pan, Y.; Wang, R.; Kang, L.L.; Xue, Q.C.; Wang, X.N.; Kong, L.D. Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats. J. Nutr. Biochem. 2014, 25, 420–428. [CrossRef] [PubMed]
    • (2014) J. Nutr. Biochem. , vol.25 , pp. 420-428
    • Zhang, Q.Y.1    Pan, Y.2    Wang, R.3    Kang, L.L.4    Xue, Q.C.5    Wang, X.N.6    Kong, L.D.7
  • 104
    • 84936754281 scopus 로고    scopus 로고
    • Simiao pill ameliorates renal glomerular injury via increasing Sirt1 expression and suppressing NF-κb/NLRP3 inflammasome activation in high fructose-fed rats
    • Ma, C.H.; Kang, L.L.; Ren, H.M.; Zhang, D.M.; Kong, L.D. Simiao pill ameliorates renal glomerular injury via increasing Sirt1 expression and suppressing NF-κb/NLRP3 inflammasome activation in high fructose-fed rats. J. Ethnopharmacol. 2015, 172, 108–117. [CrossRef] [PubMed]
    • (2015) J. Ethnopharmacol. , vol.172 , pp. 108-117
    • Ma, C.H.1    Kang, L.L.2    Ren, H.M.3    Zhang, D.M.4    Kong, L.D.5
  • 105
    • 84928644340 scopus 로고    scopus 로고
    • Wuling san protects kidney dysfunction by inhibiting renal TLR4/MyD88 signaling and NLRP3 inflammasome activation in high fructose-induced hyperuricemic mice
    • Yang, Y.; Zhang, D.M.; Liu, J.H.; Hu, L.S.; Xue, Q.C.; Ding, X.Q.; Kong, L.D. Wuling san protects kidney dysfunction by inhibiting renal TLR4/MyD88 signaling and NLRP3 inflammasome activation in high fructose-induced hyperuricemic mice. J. Ethnopharmacol. 2015, 169, 49–59. [CrossRef] [PubMed]
    • (2015) J. Ethnopharmacol. , vol.169 , pp. 49-59
    • Yang, Y.1    Zhang, D.M.2    Liu, J.H.3    Hu, L.S.4    Xue, Q.C.5    Ding, X.Q.6    Kong, L.D.7
  • 107
    • 84877811000 scopus 로고    scopus 로고
    • Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats
    • Tian, Y.F.; He, C.T.; Chen, Y.T.; Hsieh, P.S. Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats. World J. Gastroenterol. WJG 2013, 19, 2761–2771. [CrossRef] [PubMed]
    • (2013) World J. Gastroenterol. WJG , vol.19 , pp. 2761-2771
    • Tian, Y.F.1    He, C.T.2    Chen, Y.T.3    Hsieh, P.S.4
  • 108
    • 84877608199 scopus 로고    scopus 로고
    • The role of uric acid in the pathogenesis of human cardiovascular disease
    • Kanbay, M.; Segal, M.; Afsar, B.; Kang, D.H.; Rodriguez-Iturbe, B.; Johnson, R.J. The role of uric acid in the pathogenesis of human cardiovascular disease. Heart 2013, 99, 759–766. [CrossRef] [PubMed]
    • (2013) Heart , vol.99 , pp. 759-766
    • Kanbay, M.1    Segal, M.2    Afsar, B.3    Kang, D.H.4    Rodriguez-Iturbe, B.5    Johnson, R.J.6
  • 109
    • 8644270550 scopus 로고    scopus 로고
    • Effects of dietary fat, nacl, and fructose on renal sodium and water transporter abundances and systemic blood pressure
    • Song, J.; Hu, X.; Shi, M.; Knepper, M.A.; Ecelbarger, C.A. Effects of dietary fat, nacl, and fructose on renal sodium and water transporter abundances and systemic blood pressure. Am. J. Physiol. Ren. Physiol. 2004, 287, F1204–F1212. [CrossRef] [PubMed]
    • (2004) Am. J. Physiol. Ren. Physiol. , vol.287 , pp. F1204-F1212
    • Song, J.1    Hu, X.2    Shi, M.3    Knepper, M.A.4    Ecelbarger, C.A.5
  • 110
    • 0037461110 scopus 로고    scopus 로고
    • Uric acid predicts clinical outcomes in heart failure insights regarding the role of xanthine oxidase and uric acid in disease pathophysiology
    • Hare, J.M.; Johnson, R.J. Uric acid predicts clinical outcomes in heart failure insights regarding the role of xanthine oxidase and uric acid in disease pathophysiology. Circulation 2003, 107, 1951. [CrossRef] [PubMed]
    • (2003) Circulation , vol.107 , pp. 1951
    • Hare, J.M.1    Johnson, R.J.2
  • 111
    • 84903749182 scopus 로고    scopus 로고
    • Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis
    • Choi, Y.J.; Yoon, Y.; Lee, K.Y.; Hien, T.T.; Kang, K.W.; Kim, K.C.; Lee, J.; Lee, M.Y.; Lee, S.M.; Kang, D.H.; et al. Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis. FASEB J. 2014, 28, 3197–3204. [CrossRef] [PubMed]
    • (2014) FASEB J. , vol.28 , pp. 3197-3204
    • Choi, Y.J.1    Yoon, Y.2    Lee, K.Y.3    Hien, T.T.4    Kang, K.W.5    Kim, K.C.6    Lee, J.7    Lee, M.Y.8    Lee, S.M.9    Kang, D.H.10
  • 112
    • 84942503439 scopus 로고    scopus 로고
    • Fructose induces prothrombotic phenotype in human endothelial cells: A new role for “added sugar” in cardio-metabolic risk
    • Cirillo, P.; Pellegrino, G.; Conte, S.; Maresca, F.; Pacifico, F.; Leonardi, A.; Trimarco, B. Fructose induces prothrombotic phenotype in human endothelial cells: A new role for “added sugar” in cardio-metabolic risk. J. Thromb. Thrombolysis 2015, 40, 444–451. [CrossRef] [PubMed]
    • (2015) J. Thromb. Thrombolysis , vol.40 , pp. 444-451
    • Cirillo, P.1    Pellegrino, G.2    Conte, S.3    Maresca, F.4    Pacifico, F.5    Leonardi, A.6    Trimarco, B.7
  • 114
    • 70349647191 scopus 로고    scopus 로고
    • Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: Renal organic ion transporter involvement
    • Hu, Q.H.; Wang, C.; Li, J.M.; Zhang, D.M.; Kong, L.D. Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: Renal organic ion transporter involvement. Am. J. Physiol. Ren. Physiol. 2009, 297, F1080. [CrossRef] [PubMed]
    • (2009) Am. J. Physiol. Ren. Physiol. , vol.297
    • Hu, Q.H.1    Wang, C.2    Li, J.M.3    Zhang, D.M.4    Kong, L.D.5
  • 115
    • 84898005689 scopus 로고    scopus 로고
    • The role of tissue renin-angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness
    • Aroor, A.R.; Demarco, V.G.; Jia, G.; Sun, Z.; Nistala, R.; Meininger, G.A.; Sowers, J.R. The role of tissue renin-angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness. Front. Endocrinol. 2013, 4, 161. [CrossRef] [PubMed]
    • (2013) Front. Endocrinol , vol.4 , pp. 161
    • Aroor, A.R.1    Demarco, V.G.2    Jia, G.3    Sun, Z.4    Nistala, R.5    Meininger, G.A.6    Sowers, J.R.7
  • 118
    • 84947967500 scopus 로고    scopus 로고
    • Dietary (−)-epicatechin mitigates oxidative stress, no metabolism alterations, and inflammation in renal cortex from fructose-fed rats
    • Prince, P.D.; Lanzi, C.R.; Toblli, J.E.; Elesgaray, R.; Oteiza, P.I.; Fraga, C.G.; Galleano, M. Dietary (−)-epicatechin mitigates oxidative stress, no metabolism alterations, and inflammation in renal cortex from fructose-fed rats. Free Radic. Biol. Med. 2015, 90, 35. [CrossRef] [PubMed]
    • (2015) Free Radic. Biol. Med , vol.90 , pp. 35
    • Prince, P.D.1    Lanzi, C.R.2    Toblli, J.E.3    Elesgaray, R.4    Oteiza, P.I.5    Fraga, C.G.6    Galleano, M.7
  • 119
    • 40449113838 scopus 로고    scopus 로고
    • Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats
    • Wang, X.; Jia, X.; Chang, T.; Desai, K.; Wu, L. Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats. J. Hypertens. 2008, 26, 765–772. [CrossRef] [PubMed]
    • (2008) J. Hypertens. , vol.26 , pp. 765-772
    • Wang, X.1    Jia, X.2    Chang, T.3    Desai, K.4    Wu, L.5
  • 120
    • 0033559856 scopus 로고    scopus 로고
    • Amp-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyltransferase is a novel target
    • Muoio, D.M.; Seefeld, K.; Witters, L.A.; Coleman, R.A. Amp-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem. J. 1999, 338 Pt 3, 783. [CrossRef] [PubMed]
    • (1999) Biochem. J. , vol.338 , pp. 783
    • Muoio, D.M.1    Seefeld, K.2    Witters, L.A.3    Coleman, R.A.4
  • 121
    • 84969834516 scopus 로고    scopus 로고
    • Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance
    • Gugliucci, A. Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance. Med. Hypotheses 2016, 93, 87. [CrossRef] [PubMed]
    • (2016) Med. Hypotheses , vol.93 , pp. 87
    • Gugliucci, A.1
  • 122
    • 70450273227 scopus 로고    scopus 로고
    • “Blinding” of amp-dependent kinase by methylglyoxal: A mechanism that allows perpetuation of hepatic insulin resistance?
    • Gugliucci, A. “Blinding” of amp-dependent kinase by methylglyoxal: A mechanism that allows perpetuation of hepatic insulin resistance? Med. Hypotheses 2009, 73, 921–924. [CrossRef] [PubMed]
    • (2009) Med. Hypotheses , vol.73 , pp. 921-924
    • Gugliucci, A.1
  • 123
    • 48849083804 scopus 로고    scopus 로고
    • Methylglyoxal production in vascular smooth muscle cells from different metabolic precursors
    • Dhar, A.; Desai, K.; Kazachmov, M.; Yu, P.; Wu, L. Methylglyoxal production in vascular smooth muscle cells from different metabolic precursors. Metab. Clin. Exp. 2008, 57, 1211–1220. [CrossRef] [PubMed]
    • (2008) Metab. Clin. Exp. , vol.57 , pp. 1211-1220
    • Dhar, A.1    Desai, K.2    Kazachmov, M.3    Yu, P.4    Wu, L.5
  • 124
    • 81055147172 scopus 로고    scopus 로고
    • Upregulation of aldolase b and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome
    • Liu, J.; Wang, R.; Desai, K.; Wu, L. Upregulation of aldolase b and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome. Cardiovasc. Res. 2011, 92, 494–503. [CrossRef] [PubMed]
    • (2011) Cardiovasc. Res. , vol.92 , pp. 494-503
    • Liu, J.1    Wang, R.2    Desai, K.3    Wu, L.4
  • 125
    • 84864242541 scopus 로고    scopus 로고
    • Aldolase b knockdown prevents high glucose-induced methylglyoxal overproduction and cellular dysfunction in endothelial cells
    • Liu, J.; Mak, T.C.; Banigesh, A.; Desai, K.; Wang, R.; Wu, L. Aldolase b knockdown prevents high glucose-induced methylglyoxal overproduction and cellular dysfunction in endothelial cells. PLoS ONE 2012, 7, e41495. [CrossRef] [PubMed]
    • (2012) Plos ONE , vol.7
    • Liu, J.1    Mak, T.C.2    Banigesh, A.3    Desai, K.4    Wang, R.5    Wu, L.6
  • 126
    • 84883786992 scopus 로고    scopus 로고
    • Increased methylglyoxal formation with upregulation of renin angiotensin system in fructose fed Sprague dawley rats
    • Dhar, I.; Dhar, A.; Wu, L.; Desai, K.M. Increased methylglyoxal formation with upregulation of renin angiotensin system in fructose fed Sprague dawley rats. PLoS ONE 2013, 8, e74212. [CrossRef] [PubMed]
    • (2013) Plos ONE , vol.8
    • Dhar, I.1    Dhar, A.2    Wu, L.3    Desai, K.M.4
  • 128
    • 40049101869 scopus 로고    scopus 로고
    • Dietary fructose and the metabolic syndrome
    • Miller, A.; Adeli, K. Dietary fructose and the metabolic syndrome. Curr. Opin. Gastroenterol. 2008, 24, 204–209. [CrossRef] [PubMed]
    • (2008) Curr. Opin. Gastroenterol. , vol.24 , pp. 204-209
    • Miller, A.1    Adeli, K.2
  • 129
    • 84962815690 scopus 로고    scopus 로고
    • Dietary fructose activates insulin signaling and inflammation in adipose tissue: Modulatory role of resveratrol
    • Pektas, M.B.; Koca, H.B.; Sadi, G.; Akar, F. Dietary fructose activates insulin signaling and inflammation in adipose tissue: Modulatory role of resveratrol. BioMed Res. Int. 2016, 2016, 8014252. [CrossRef] [PubMed]
    • (2016) Biomed Res. Int , vol.2016
    • Pektas, M.B.1    Koca, H.B.2    Sadi, G.3    Akar, F.4
  • 130
    • 84901424065 scopus 로고    scopus 로고
    • Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity
    • Jin, Y.H.; Park, Y.J.; Ham, M.; Kim, J.B. Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. Mol. Cells 2014, 37, 365–371.
    • (2014) Mol. Cells , vol.37 , pp. 365-371
    • Jin, Y.H.1    Park, Y.J.2    Ham, M.3    Kim, J.B.4
  • 131
    • 84905650438 scopus 로고    scopus 로고
    • Fructose and uric acid: Is there a role in endothelial function? Curr
    • Jia, G.; Aroor, A.R.; Whaley-Connell, A.T.; Sowers, J.R. Fructose and uric acid: Is there a role in endothelial function? Curr. Hypertens. Rep. 2014, 16, 1–7. [CrossRef] [PubMed]
    • (2014) Hypertens. Rep. , vol.16 , pp. 1-7
    • Jia, G.1    Aroor, A.R.2    Whaley-Connell, A.T.3    Sowers, J.R.4
  • 133
    • 33750584214 scopus 로고    scopus 로고
    • Tlr4 links innate immunity and fatty acid-induced insulin resistance
    • Shi, H.; Kokoeva, M.V.; Inouye, K.; Tzameli, I.; Yin, H.; Flier, J.S. Tlr4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Investig. 2006, 116, 3015–3025. [CrossRef] [PubMed]
    • (2006) J. Clin. Investig. , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3    Tzameli, I.4    Yin, H.5    Flier, J.S.6
  • 134
    • 84870170324 scopus 로고    scopus 로고
    • Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression
    • Jansen, H.J.; Van, E.P.; Koenen, T.; Joosten, L.A.; Netea, M.G.; Tack, C.J.; Stienstra, R. Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression. Endocrinology 2012, 153, 5866–5874. [CrossRef] [PubMed]
    • (2012) Endocrinology , vol.153 , pp. 5866-5874
    • Jansen, H.J.1    Van, E.P.2    Koenen, T.3    Joosten, L.A.4    Netea, M.G.5    Tack, C.J.6    Stienstra, R.7
  • 135
    • 84887215808 scopus 로고    scopus 로고
    • Long-term fructose feeding changes the expression of leptin receptors and autophagy genes in the adipose tissue and liver of male rats: A possible link to elevated triglycerides
    • Äijälä, M.; Malo, E.; Ukkola, O.; Bloigu, R.; Lehenkari, P.; Autioharmainen, H.; Santaniemi, M.; Kesäniemi, Y.A. Long-term fructose feeding changes the expression of leptin receptors and autophagy genes in the adipose tissue and liver of male rats: A possible link to elevated triglycerides. Genes Nutr. 2013, 8, 623–635. [CrossRef] [PubMed]
    • (2013) Genes Nutr , vol.8 , pp. 623-635
    • Äijälä, M.1    Malo, E.2    Ukkola, O.3    Bloigu, R.4    Lehenkari, P.5    Autioharmainen, H.6    Santaniemi, M.7    Kesäniemi, Y.A.8
  • 136
    • 0035513703 scopus 로고    scopus 로고
    • Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state
    • Teruel, T.; Hernandez, R.; Lorenzo, M. Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Diabetes 2001, 50, 2563–2571. [CrossRef] [PubMed]
    • (2001) Diabetes , vol.50 , pp. 2563-2571
    • Teruel, T.1    Hernandez, R.2    Lorenzo, M.3
  • 137
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking tnf-alpha function
    • Uysal, K.T.; Wiesbrock, S.M.; Marino, M.W.; Hotamisligil, G.S. Protection from obesity-induced insulin resistance in mice lacking tnf-alpha function. Nature 1997, 389, 610–614. [PubMed]
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 138
    • 0037732481 scopus 로고    scopus 로고
    • The adipocyte in insulin resistance: Key molecules and the impact of the thiazolidinediones
    • Arner, P. The adipocyte in insulin resistance: Key molecules and the impact of the thiazolidinediones. Trends Endocrinol. Metab. 2003, 14, 137–145. [CrossRef]
    • (2003) Trends Endocrinol. Metab. , vol.14 , pp. 137-145
    • Arner, P.1
  • 139
    • 0030061922 scopus 로고    scopus 로고
    • Irs-1-mediated inhibition of insulin receptor tyrosine kinase activity in tnf-alpha- and obesity-induced insulin resistance
    • Hotamisligil, G.S.; Peraldi, P.; Budavari, A.; Ellis, R.; White, M.F.; Spiegelman, B.M. Irs-1-mediated inhibition of insulin receptor tyrosine kinase activity in tnf-alpha- and obesity-induced insulin resistance. Science 1996, 271, 665–668. [CrossRef] [PubMed]
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 140
    • 12144290761 scopus 로고    scopus 로고
    • Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo
    • Kim, H.J.; Higashimori, T.; Park, S.Y.; Choi, H.; Dong, J.; Kim, Y.J.; Noh, H.L.; Cho, Y.R.; Cline, G.; Kim, Y.B. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 2004, 53, 1060–1067. [CrossRef] [PubMed]
    • (2004) Diabetes , vol.53 , pp. 1060-1067
    • Kim, H.J.1    Higashimori, T.2    Park, S.Y.3    Choi, H.4    Dong, J.5    Kim, Y.J.6    Noh, H.L.7    Cho, Y.R.8    Cline, G.9    Kim, Y.B.10
  • 141
    • 84880170528 scopus 로고    scopus 로고
    • High sugar intake and development of skeletal muscle insulin resistance and inflammation in mice: A protective role for ppar-δ agonism
    • Benetti, E.; Mastrocola, R.; Rogazzo, M.; Chiazza, F.; Aragno, M.; Fantozzi, R.; Collino, M.; Minetto, M.A. High sugar intake and development of skeletal muscle insulin resistance and inflammation in mice: A protective role for ppar-δ agonism. Mediat. Inflamm. 2013, 2013, 509502. [CrossRef] [PubMed]
    • (2013) Mediat. Inflamm , vol.2013
    • Benetti, E.1    Mastrocola, R.2    Rogazzo, M.3    Chiazza, F.4    Aragno, M.5    Fantozzi, R.6    Collino, M.7    Minetto, M.A.8
  • 143
    • 85016480879 scopus 로고    scopus 로고
    • Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMPK and sirt1 activities
    • Liu, Z.; Jiang, C.; Zhang, J.; Liu, B.; Du, Q. Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMPK and sirt1 activities. J. Diabetes 2015, 184, 98–105.
    • (2015) J. Diabetes , vol.184 , pp. 98-105
    • Liu, Z.1    Jiang, C.2    Zhang, J.3    Liu, B.4    Du, Q.5
  • 145
    • 85005990865 scopus 로고    scopus 로고
    • Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice
    • De Sousa Rodrigues, M.E.; Bekhbat, M.; Houser, M.C.; Chang, J.; Walker, D.I.; Jones, D.P.; Oller do Nascimento, C.M.; Barnum, C.J.; Tansey, M.G. Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice. Brain Behav. Immun. 2017, 59, 158–172. [CrossRef] [PubMed]
    • (2017) Brain Behav. Immun. , vol.59 , pp. 158-172
    • De Sousa Rodrigues, M.E.1    Bekhbat, M.2    Houser, M.C.3    Chang, J.4    Walker, D.I.5    Jones, D.P.6    Oller Do Nascimento, C.M.7    Barnum, C.J.8    Tansey, M.G.9
  • 146
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang, X.; Zhang, G.; Zhang, H.; Karin, M.; Bai, H.; Cai, D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008, 135, 61–73. [CrossRef] [PubMed]
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 148
    • 84953791558 scopus 로고    scopus 로고
    • Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin
    • Xu, M.X.; Yu, R.; Shao, L.F.; Zhang, Y.X.; Ge, C.X.; Liu, X.M.; Wu, W.Y.; Li, J.M.; Kong, L.D. Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin. Brain Behav. Immun. 2016, 58, 69–81. [CrossRef] [PubMed]
    • (2016) Brain Behav. Immun. , vol.58 , pp. 69-81
    • Xu, M.X.1    Yu, R.2    Shao, L.F.3    Zhang, Y.X.4    Ge, C.X.5    Liu, X.M.6    Wu, W.Y.7    Li, J.M.8    Kong, L.D.9
  • 149
    • 84895919149 scopus 로고    scopus 로고
    • High-fructose diet leads to visceral adiposity and hypothalamic leptin resistance in male rats—Do glucocorticoids play a role?
    • Bursać, B.N.; Vasiljević, A.D.; Nestorović, N.M.; Veličković, N.A.; Matić, G.M.; Djordjevic, A.D. High-fructose diet leads to visceral adiposity and hypothalamic leptin resistance in male rats—Do glucocorticoids play a role? J. Nutr. Biochem. 2014, 25, 446. [CrossRef] [PubMed]
    • (2014) J. Nutr. Biochem. , vol.25 , pp. 446
    • Bursać, B.N.1    Vasiljević, A.D.2    Nestorović, N.M.3    Veličković, N.A.4    Matić, G.M.5    Djordjevic, A.D.6
  • 150
  • 151
    • 84889636080 scopus 로고    scopus 로고
    • Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin and adiponectin: Relationships with metabolic outcomes
    • Rezvani, R.; Cianflone, K.; Mcgahan, J.P.; Berglund, L.; Bremer, A.A.; Keim, N.L.; Griffen, S.C.; Havel, P.J.; Stanhope, K.L. Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin and adiponectin: Relationships with metabolic outcomes. Obesity 2013, 21, 2471–2480. [CrossRef] [PubMed]
    • (2013) Obesity , vol.21 , pp. 2471-2480
    • Rezvani, R.1    Cianflone, K.2    McGahan, J.P.3    Berglund, L.4    Bremer, A.A.5    Keim, N.L.6    Griffen, S.C.7    Havel, P.J.8    Stanhope, K.L.9
  • 153
    • 48249117609 scopus 로고    scopus 로고
    • Adiponectin reduces plasma triglyceride by increasing VLDL triglyceride catabolism
    • Qiao, L.; Zou, C.; van der Westhuyzen, D.R.; Shao, J. Adiponectin reduces plasma triglyceride by increasing VLDL triglyceride catabolism. Diabetes 2008, 57, 1824–1833. [CrossRef] [PubMed]
    • (2008) Diabetes , vol.57 , pp. 1824-1833
    • Qiao, L.1    Zou, C.2    Van Der Westhuyzen, D.R.3    Shao, J.4
  • 154
    • 44449111714 scopus 로고    scopus 로고
    • Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans
    • Swarbrick, M.M.; Havel, P.J. Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans. Metab. Syndr. Relat. Disord. 2008, 6, 87–102. [CrossRef] [PubMed]
    • (2008) Metab. Syndr. Relat. Disord. , vol.6 , pp. 87-102
    • Swarbrick, M.M.1    Havel, P.J.2
  • 157
    • 84921908127 scopus 로고    scopus 로고
    • Adiponectin resistance and proinflammatory changes in the visceral adipose tissue induced by fructose consumption via ketohexokinase-dependent pathway
    • Marek, G.; Pannu, V.; Shanmugham, P.; Pancione, B.; Mascia, D.; Crosson, S.; Ishimoto, T.; Sautin, Y.Y. Adiponectin resistance and proinflammatory changes in the visceral adipose tissue induced by fructose consumption via ketohexokinase-dependent pathway. Diabetes 2015, 64, 508–518. [CrossRef] [PubMed]
    • (2015) Diabetes , vol.64 , pp. 508-518
    • Marek, G.1    Pannu, V.2    Shanmugham, P.3    Pancione, B.4    Mascia, D.5    Crosson, S.6    Ishimoto, T.7    Sautin, Y.Y.8
  • 163
    • 63049111215 scopus 로고    scopus 로고
    • Full-length adiponectin protects hepatocytes from palmitate-induced apoptosis via inhibition of c-jun NH2 terminal kinase
    • Jung, T.W.; Lee, Y.J.; Lee, M.W.; Kim, S.M.; Jung, T.W. Full-length adiponectin protects hepatocytes from palmitate-induced apoptosis via inhibition of c-jun NH2 terminal kinase. FEBS J. 2009, 276, 2278–2284. [CrossRef] [PubMed]
    • (2009) FEBS J , vol.276 , pp. 2278-2284
    • Jung, T.W.1    Lee, Y.J.2    Lee, M.W.3    Kim, S.M.4    Jung, T.W.5
  • 166
    • 33747034520 scopus 로고    scopus 로고
    • Leptin suppresses stearoyl-coa desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
    • Biddinger, S.B.; Miyazaki, M.; Boucher, J.; Ntambi, J.M.; Kahn, C.R. Leptin suppresses stearoyl-coa desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes 2006, 55, 2032–2041. [CrossRef] [PubMed]
    • (2006) Diabetes , vol.55 , pp. 2032-2041
    • Biddinger, S.B.1    Miyazaki, M.2    Boucher, J.3    Ntambi, J.M.4    Kahn, C.R.5
  • 168
    • 51249118983 scopus 로고    scopus 로고
    • Effects of sucrose, glucose and fructose on peripheral and central appetite signals
    • Lindqvist, A.; Baelemans, A.; Erlanson-Albertsson, C. Effects of sucrose, glucose and fructose on peripheral and central appetite signals. Regul. Pept. 2008, 150, 26–32. [CrossRef] [PubMed]
    • (2008) Regul. Pept. , vol.150 , pp. 26-32
    • Lindqvist, A.1    Baelemans, A.2    Erlanson-Albertsson, C.3
  • 169
    • 84946486687 scopus 로고    scopus 로고
    • Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time
    • Sellmann, C.; Priebs, J.; Landmann, M.; Degen, C.; Engstler, A.J.; Jin, C.J.; Gärttner, S.; Spruss, A.; Huber, O.; Bergheim, I. Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time. J. Nutr. Biochem. 2015, 26, 1183–1192. [CrossRef] [PubMed]
    • (2015) J. Nutr. Biochem. , vol.26 , pp. 1183-1192
    • Sellmann, C.1    Priebs, J.2    Landmann, M.3    Degen, C.4    Engstler, A.J.5    Jin, C.J.6    Gärttner, S.7    Spruss, A.8    Huber, O.9    Bergheim, I.10
  • 170
    • 70350075402 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice
    • Spruss, A.; Kanuri, G.; Wagnerberger, S.; Haub, S.; Bischoff, S.C.; Bergheim, I. Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. Hepatology 2009, 50, 1094–1104. [CrossRef] [PubMed]
    • (2009) Hepatology , vol.50 , pp. 1094-1104
    • Spruss, A.1    Kanuri, G.2    Wagnerberger, S.3    Haub, S.4    Bischoff, S.C.5    Bergheim, I.6
  • 172
    • 84865490141 scopus 로고    scopus 로고
    • High fructose consumption can induce endotoxemia
    • Dogan, S.; Celikbilek, M.; Guven, K. High fructose consumption can induce endotoxemia. Gastroenterology 2012, 143, e29. [CrossRef] [PubMed]
    • (2012) Gastroenterology , vol.143
    • Dogan, S.1    Celikbilek, M.2    Guven, K.3
  • 174
    • 84862999195 scopus 로고    scopus 로고
    • Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function
    • Spruss, A.; Kanuri, G.; Stahl, C.; Bischoff, S.C.; Bergheim, I. Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function. Lab. Investig. 2012, 92, 1020–1032. [CrossRef] [PubMed]
    • (2012) Lab. Investig. , vol.92 , pp. 1020-1032
    • Spruss, A.1    Kanuri, G.2    Stahl, C.3    Bischoff, S.C.4    Bergheim, I.5
  • 176
    • 0345447585 scopus 로고    scopus 로고
    • Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms
    • Bruewer, M.; Luegering, A.; Kucharzik, T.; Parkos, C.A.; Madara, J.L.; Hopkins, A.M.; Nusrat, A. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J. Immunol. 2003, 171, 6164. [CrossRef] [PubMed]
    • (2003) J. Immunol. , vol.171 , pp. 6164
    • Bruewer, M.1    Luegering, A.2    Kucharzik, T.3    Parkos, C.A.4    Madara, J.L.5    Hopkins, A.M.6    Nusrat, A.7
  • 177
    • 84855387746 scopus 로고    scopus 로고
    • Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury
    • Frazier, T.H.; Dibaise, J.K.; Mcclain, C.J. Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury. J. Parenter. Enter. Nutr. 2011, 35, S14–S20. [CrossRef] [PubMed]
    • (2011) J. Parenter. Enter. Nutr , vol.35 , pp. S14-S20
    • Frazier, T.H.1    Dibaise, J.K.2    McClain, C.J.3
  • 178
    • 49449083979 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake
    • Thuy, S.; Ladurner, R.; Volynets, V.; Wagner, S.; Strahl, S.; Königsrainer, A.; Maier, K.P.; Bischoff, S.C.; Bergheim, I. Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J. Nutr. 2008, 138, 1452. [PubMed]
    • (2008) J. Nutr. , vol.138 , pp. 1452
    • Thuy, S.1    Ladurner, R.2    Volynets, V.3    Wagner, S.4    Strahl, S.5    Königsrainer, A.6    Maier, K.P.7    Bischoff, S.C.8    Bergheim, I.9
  • 179
    • 84903893149 scopus 로고    scopus 로고
    • Toll-like receptor-4 signalling in the progression of non-alcoholic fatty liver disease induced by high-fat and high-fructose diet in mice
    • Liu, J.; Zhuang, Z.J.; Bian, D.X.; Ma, X.J.; Xun, Y.H.; Yang, W.J.; Luo, Y.; Liu, Y.L.; Jia, L.; Wang, Y.; et al. Toll-like receptor-4 signalling in the progression of non-alcoholic fatty liver disease induced by high-fat and high-fructose diet in mice. Clin. Exp. Pharmacol. Physiol. 2014, 41, 482–488. [CrossRef] [PubMed]
    • (2014) Clin. Exp. Pharmacol. Physiol , vol.41 , pp. 482-488
    • Liu, J.1    Zhuang, Z.J.2    Bian, D.X.3    Ma, X.J.4    Xun, Y.H.5    Yang, W.J.6    Luo, Y.7    Liu, Y.L.8    Jia, L.9    Wang, Y.10
  • 180
    • 85015849374 scopus 로고    scopus 로고
    • Loss of lipopolysaccharide-binding protein attenuates the development of diet-induced non-alcoholic fatty liver disease (NAFLD) in mice
    • Jin, C.J.; Engstler, A.J.; Ziegenhardt, D.; Bischoff, S.C.; Trautwein, C.; Bergheim, I. Loss of lipopolysaccharide-binding protein attenuates the development of diet-induced non-alcoholic fatty liver disease (NAFLD) in mice. J. Gastroenterol. Hepatol. 2017, 32, 708–715. [CrossRef] [PubMed]
    • (2017) J. Gastroenterol. Hepatol. , vol.32 , pp. 708-715
    • Jin, C.J.1    Engstler, A.J.2    Ziegenhardt, D.3    Bischoff, S.C.4    Trautwein, C.5    Bergheim, I.6
  • 181
    • 84861547908 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of x-box binding protein-1 in mice
    • Ye, D.; Li, F.Y.L.; Lam, K.S.L.; Li, H.; Jia, W.; Yu, W.; Man, K.; Lo, C.M.; Li, X.; Xu, A. Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of x-box binding protein-1 in mice. Gut 2012, 61, 1058. [CrossRef] [PubMed]
    • (2012) Gut , vol.61 , pp. 1058
    • Ye, D.1    Li, F.Y.L.2    Lam, K.S.L.3    Li, H.4    Jia, W.5    Yu, W.6    Man, K.7    Lo, C.M.8    Li, X.9    Xu, A.10
  • 183
    • 79751531480 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS) induction of nitric oxide synthase-2 and cyclooxygenase-2 is impaired in fructose overloaded rats
    • Carranza, A.; Litterio, M.C.; Prince, P.D.; Mayer, M.A.; Ingaramo, P.I.; Ronco, M.T.; Peredo, H.A.; Puyó, A.M.; Galleano, M. Lipopolysaccharide (LPS) induction of nitric oxide synthase-2 and cyclooxygenase-2 is impaired in fructose overloaded rats. Life Sci. 2011, 88, 307–313. [CrossRef] [PubMed]
    • (2011) Life Sci , vol.88 , pp. 307-313
    • Carranza, A.1    Litterio, M.C.2    Prince, P.D.3    Mayer, M.A.4    Ingaramo, P.I.5    Ronco, M.T.6    Peredo, H.A.7    Puyó, A.M.8    Galleano, M.9


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