Genistein modulates NF-κB-associated renal inflammation, fibrosis and podocyte abnormalities in fructose-fed rats

European Journal of Pharmacology

Volumn 667, Issue 1-3, 2011, Pages 355-364

  Palanisamy, Nallasamy ^a   Kannappan, Sriramajayam ^a   Anuradha, Carani Venkataraman ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Fructose; Genistein; Kidney; Nuclear factor B; Podocyte

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; GENISTEIN; INSULIN; INTERLEUKIN 6; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COUNT; CELL PROLIFERATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FIBROGENESIS; GLOMERULUS FILTRATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; INSULIN RESISTANCE; KIDNEY FIBROSIS; KIDNEY STRUCTURE; MALE; NEPHRITIS; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; STRUCTURE ANALYSIS; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION; UPREGULATION;

ACTINS; ANIMALS; BIOLOGICAL MARKERS; COLLAGEN; DIETARY CARBOHYDRATES; FIBROSIS; FRUCTOSE; GENE EXPRESSION REGULATION; GENISTEIN; INFLAMMATION; INTERLEUKIN-6; KIDNEY DISEASES; MALE; PODOCYTES; RATS; RATS, WISTAR; RECEPTORS, IMMUNOLOGIC; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80052032667     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.06.011     Document Type: Article

References (47)

1. M.C. Arkan, A.L. Hevener, F.R. Greten, S. Maeda, Z.W. Li, J.M. Long, A. Wynshaw-Boris, G. Poli, J. Olefsky, and M. Karin IKK-beta links inflammation to obesity-induced insulin resistance Nat. Med. 11 2005 191 198 (Pubitemid 40321355)
2. S. Barnes Soy isoflavones phystoestrogens and what else? J. Nutr. 134 2004 1225S 1228S (Pubitemid 38619968)
3. S. Barnes, B. Boersma, R. Patel, M. Kirk, V.M. Darley-Usmar, H. Kim, and J. Xu Isoflavonoids and chronic disease: mechanisms of action Biofactors 12 2000 209 215 (Pubitemid 32107408)
4. H. Basciano, L. Federico, and K. Adeli Fructose, insulin resistance, and metabolic dyslipidemia Nutr. Metab. 2 2005 5 (Lond)
5. A. Bierhaus, P.M. Humpert, M. Morcos, T. Wendt, T. Chavakis, B. Arnold, D.M. Stern, and P.P. Nawroth Understanding RAGE, the receptor for advanced glycation end products J. Mol. Med. 83 2005 876 886 (Pubitemid 41598688)
6. G. Boden, P. She, M. Mozzoli, P. Cheung, K. Gumireddy, P. Reddy, X. Xiang, Z. Luo, and N. Ruderman Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver Diabetes 54 2005 3458 3465 (Pubitemid 43334336)
7. L. Chen, J. Zhang, Y. Zhang, Y. Wang, and B. Wang Improvement of inflammatory responses associated with NF-kappa B pathway in kidneys from diabetic rats Inflamm. Res. 57 2008 199 204
8. P. Dandona, A. Aljada, and A. Bandyopadhyay Inflammation: the link between insulin resistance, obesity and diabetes Trends Immunol. 25 2004 4 7 (Pubitemid 38032801)
9. J. Davis, J. Steinle, D.A. Higginbotham, J. Oitker, R.G. Peterson, and W.J. Banz Soy protein influences insulin sensitivity and cardiovascular risk in male lean SHHF rats Horm. Metab. Res. 37 2005 309 315 (Pubitemid 40896215)
10. L.B. Foster, and R.T. Dunn Stable reagents for determination of serum triglycerides by a colorimetric Hantzsch condensation method Clin. Chem. 19 1973 338 340
11. D.B. Fournier, J.W. Erdman Jr. , and G.B. Gordon Soy, its components, and cancer prevention: a review of the in vitro, animal, and human data Cancer Epidemiol. Biomark. Prev. 7 1998 1055 1065 (Pubitemid 28514109)
12. A.R. Gaby Adverse effects of dietary fructose Altern. Med. Rev. 10 2005 294 306 (Pubitemid 41803484)
13. A.S. Ibrahim, M.M. El-Shishtawy, A. Pena Jr. , and G.I. Liou Genistein attenuates retinal inflammation associated with diabetes by targeting of microglial activation Mol. Vis. 16 2010 2033 2042
14. V. Jayagopal, P. Albertazzi, E.S. Kilpatrick, E.M. Howarth, P.E. Jennings, D.A. Hepburn, and S.L. Atkin Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes Diab. Care 25 2002 1709 1714 (Pubitemid 41071075)
15. P. Kijkuokool, I.S. Parhar, and S. Malaivijitnond Genistein enhances N-nitrosomethylurea-induced rat mammary tumorigenesis Cancer Lett. 242 2006 53 59 (Pubitemid 44485289)
16. A. Kuhad, M. Bishnoi, V. Tiwari, and K. Chopra Suppression of NF-kappabeta signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits Pharmacol. Biochem. Behav. 92 2009 251 259
17. G. Lastra, C. Manrique, S.I. McFarlane, and J.R. Sowers Cardiometabolic syndrome and chronic kidney disease Curr. Diab. Rep. 6 2006 207 212
18. M.A. Lazar The humoral side of insulin resistance Nat. Med. 12 2006 43 44 (Pubitemid 43050062)
19. Y.W. Lee, and W.H. Lee Protective effects of genistein on proinflammatory pathways in human brain microvascular endothelial cells J. Nutr. Biochem. 19 2008 819 825
20. D. Liu, W. Zhen, Z. Yang, J.D. Carter, H. Si, and K.A. Reynolds Genistein acutely stimulates insulin secretion in pancreatic beta-cells through a cAMP-dependent protein kinase pathway Diabetes 55 2006 1043 1050 (Pubitemid 44100180)
21. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
22. H. Lu, J.X. Shi, D.M. Zhang, H.L. Chen, M. Qi, and H.X. Yin Genistein, a soybean isoflavone, reduces the production of pro-inflammatory and adhesion molecules induced by hemolysate in brain microvascular endothelial cells Acta Neurol. Belg. 109 2009 32 37
23. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419 (Pubitemid 15018832)
24. E.T. McCarthy, R. Sharma, M. Sharma, J.Z. Li, X.L. Ge, K.N. Dileepan, and V.J. Savin TNF-alpha increases albumin permeability of isolated rat glomeruli through the generation of superoxide J. Am. Soc. Nephrol. 9 1998 433 438
25. A. Miller, and K. Adeli Dietary fructose and the metabolic syndrome Curr. Opin. Gastroenterol. 24 2008 204 209 (Pubitemid 351322788)
26. T. Nakagawa, K.R. Tuttle, R.A. Short, and R.J. Johnson Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome Nat. Clin. Pract. Nephrol. 1 2005 80 86
27. J.F. Navarro, F.J. Milena, C. Mora, C. Leon, and J. Garcia Renal pro-inflammatory cytokine gene expression in diabetic nephropathy: effect of angiotensin-converting enzyme inhibition and pentoxifylline administration Am. J. Nephrol. 26 2006 562 570 (Pubitemid 46143878)
28. Y.Y. Ng, T.P. Huang, W.C. Yang, Z.P. Chen, A.H. Yang, W. Mu, D.J. Nikolic-Paterson, R.C. Atkins, and H.Y. Lan Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats Kidney Int. 54 1998 864 876 (Pubitemid 28397404)
29. W.G. Niehaus, and B. Samuelsson Formation of MDA from phospholipid arachidonate during microsomal lipid peroxidation Eur. J. Biochem. 6 1968 126 130
30. N. Palanisamy, P. Viswanathan, and C.V. Anuradha Effect of genistein, a soy isoflavone, on whole body insulin sensitivity and renal damage induced by a high-fructose diet Ren. Fail. 30 2008 645 654
31. C.E. Park, H. Yun, E.B. Lee, B.I. Min, H. Bae, W. Choe, I. Kang, S.S. Kim, and J. Ha The antioxidant effects of genistein are associated with AMP-activated protein kinase activation and PTEN induction in prostate cancer cells J. Med. Food 13 2010 815 820
32. B. Pat, M.D. Hughson, J.L. Nicol, W.E. Hoy, and G.C. Gobe A comparison of pathomolecular markers of fibrosis and morphology in kidney from autopsies of African Americans and whites Virchows Arch. 450 2007 41 50 (Pubitemid 46360748)
33. M.A. Paz, R.W. Lent, B. Faris, C. Frazblan, O.O. Blumfeld, and P.M. Gallop Aldehydes in native and denatured calfskin procollagen Biochem. Biophys. Res. Com. 34 1969 221 229
34. P. Rajasekar, P. Viswanathan, and C.V. Anuradha Renoprotective action of L-carnitine in fructose-induced metabolic syndrome Diab. Obes. Metab. 10 2008 171 180
35. P. Rao, and T.N. Pattabiraman Reevaluation of the phenol sulphuric acid reaction for the estimation of hexoses and pentoses Anal. Biochem. 181 1990 18 22 (Pubitemid 19210783)
36. L.G. Sanchez-Lozada, E. Tapia, A. Jimenez, P. Bautista, M. Cristobal, T. Nepomuceno, V. Soto, C. Avila-Casado, T. Nakagawa, R.J. Johnson, J. Herrera-Acosta, and M. Franco Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats Am. J. Physiol. Ren. Physiol. 292 2007 F423 F429
37. K. Sharma, and F.N. Ziyadeh Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator Diabetes 44 1995 1139 1146
38. R. Sharma, A. Khanna, M. Sharma, and V.J. Savin Transforming growth factor-beta1 increases albumin permeability of isolated rat glomeruli via hydroxyl radicals Kidney Int. 58 2000 131 136 (Pubitemid 30429857)
39. D.A. Shoham, R. Durazo-Arvizu, H. Kramer, A. Luke, S. Vupputuri, A. Kshirsagar, and R.S. Cooper Sugary soda consumption and albuminuria: results from the National Health and Nutrition Examination Survey, 1999-2004 PLoS One 3 2008 e3431
40. W.E. Smoyer, and P. Mundel Regulation of podocyte structure during the development of nephrotic syndrome J. Mol. Med. 76 1998 172 183 (Pubitemid 28098703)
41. A.L. Tan, J.M. Forbes, and M.E. Cooper AGE, RAGE, and ROS in diabetic nephropathy Semin. Nephrol. 27 2007 130 143 (Pubitemid 46550311)
42. N. Togashi, N. Ura, K. Higashiura, H. Murakami, and K. Shimamoto Effect of TNF-alpha-converting enzyme inhibitor on insulin resistance in fructose-fed rats Hypertension 39 2002 578 580 (Pubitemid 34165186)
43. Z. Wang, T. Jiang, J. Li, G. Proctor, J.L. McManaman, S. Lucia, S. Chua, and M. Levi Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVB db/db mice with type 2 diabetes Diabetes 54 2005 2328 2335 (Pubitemid 41134259)
44. J.F. Woessner The determination of hydroxy proline in tissue and protein samples containing small portions of this amino acid Arch. Biochem. Biophys. 93 1961 440 447
45. M. Yuan, N. Konstantopoulos, J. Lee, L. Hansen, Z.W. Li, M. Karin, and S.E. Shoelson Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta Science 293 2001 1673 1677 (Pubitemid 32807849)
46. W.J. Yuan, F.Y. Jia, and J.Z. Meng Effects of genistein on secretion of extracellular matrix components and transforming growth factor beta in high-glucose-cultured rat mesangial cells J. Artif. Organs 12 2009 242 246
47. J. Zhuo, M. Ohishi, and F.A. Mendelsohn Roles of AT1 and AT2 receptors in the hypertensive Ren-2 gene transgenic rat kidney Hypertension 33 1999 347 353 (Pubitemid 29065683)