Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis

FASEB Journal

Volumn 28, Issue 7, 2014, Pages 3197-3204

  Choi, You Jin ^a,b   Yoon, Yujin ^a,b   Lee, Kang Yo ^a,b   Hien, Tran Thi ^a,b   Kang, Keon Wook ^a,b   Kim, Kyong Cheol ^a,b   Lee, Jeewoo ^a,b   Lee, Moo Yeol ^c   Lee, Seung Mi ^a,d   Kang, Duk Hee ^e   Lee, Byung Hoon ^a,b  

^a Seoul National University   (South Korea)

^b Res Inst of Pharmaceutical Sci   (South Korea)

^c Dongguk University   (South Korea)

^d Seoul National University Boramae Hospital   (South Korea)

^e Ewha Womans University School of Medicine   (South Korea)

Author keywords

ENOS; Hypertension

Indexed keywords

ALLANTOXANAMIDE; ALLOPURINOL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; URIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPERTENSION; HYPERURICEMIA; INSULIN RESISTANCE; INSULIN RESPONSE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; URIC ACID BLOOD LEVEL; VASCULAR RESISTANCE; VASCULAR RING; VASODILATATION;

ENOS; HYPERTENSION;

ANIMALS; ARTERIAL PRESSURE; CELLS, CULTURED; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPERTENSION; HYPERURICEMIA; INSULIN; INSULIN RESISTANCE; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; URIC ACID; VASODILATION;

EID: 84903749182     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-247148     Document Type: Article

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