Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats

Journal of Nutritional Biochemistry

Volumn 25, Issue 4, 2014, Pages 420-428

  Zhang, Qing Yu ^a   Pan, Ying ^a   Wang, Rong ^a   Kang, Lin Lin ^a   Xue, Qiao Chu ^a   Wang, Xiao Ning ^a   Kong, Ling Dong ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Fructose; Hypothalamic insulin signaling; NLRP3 inflammasome; Quercetin; TXNIP

Indexed keywords

ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; ALLOPURINOL; DRINKING WATER; FRUCTOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INSULIN; INSULIN RECEPTOR; INTERLEUKIN 1BETA; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PROTEIN KINASE; PROTEIN KINASE B; QUERCETIN; THIOREDOXIN INTERACTING PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; CELL RECEPTOR; GLUTAMIC ACID; GLUTAMINE; NOD-LIKE RECEPTOR 3, RAT; TXNIP PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HYPERLIPIDEMIA; HYPOTHALAMUS; IN VIVO STUDY; INFLAMMATION; INSULIN RESISTANCE; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; DRUG EFFECTS; HYPERLIPIDEMIAS; HYPERURICEMIA; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS;

ANIMALS; CARRIER PROTEINS; FRUCTOSE; GLUTAMIC ACID; GLUTAMINE; HYPERLIPIDEMIAS; HYPERURICEMIA; HYPOTHALAMUS; INFLAMMASOMES; INSULIN; INSULIN RESISTANCE; MALE; NF-KAPPA B; QUERCETIN; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION;

EID: 84895922899     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2013.11.014     Document Type: Article

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