Aldolase B knockdown prevents high glucose-induced methylglyoxal overproduction and cellular dysfunction in endothelial cells

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Liu, Jianghai ^a   Mak, Timothy Chun Ping ^a   Banigesh, Ali ^a   Desai, Kaushik ^a   Wang, Rui ^b   Wu, Lingyun ^a,b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b LAKEHEAD UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ADVANCED GLYCATION END PRODUCT; ALAGEBRIUM; AMINE OXIDASE (FLAVIN CONTAINING); AMINOGUANIDINE; CARBONYL DERIVATIVE; CYTOCHROME P450 2E1; FRUCTOSE; FRUCTOSE BISPHOSPHATE ALDOLASE; FRUCTOSE BISPHOSPHATE ALDOLASE A; FRUCTOSE BISPHOSPHATE ALDOLASE B; GLUCOSE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; METHYLGLYOXAL; N ACETYLGLUCOSAMINE; PROTEIN KINASE C; SEMICARBAZIDE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL FUNCTION; CELLULAR DYSFUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; LIPID METABOLISM; OXIDATIVE STRESS; PROTEIN METABOLISM; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; WESTERN BLOTTING;

ACETYLGLUCOSAMINE; CELL MEMBRANE; DNA; FLUORESCEINS; FRUCTOSE-BISPHOSPHATE ALDOLASE; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; METABOLIC NETWORKS AND PATHWAYS; NF-KAPPA B; OXIDATION-REDUCTION; PROTEIN KINASE C; PROTEIN TRANSPORT; PYRUVALDEHYDE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84864242541     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041495     Document Type: Article

References (48)

1. Brownlee M, (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820.
2. Hanssen KF, (1997) Blood glucose control and microvascular and macrovascular complications in diabetes. Diabetes 46: S101-103.
3. Scalia R, Gong Y, Berzins B, Zhao LJ, Sharma K, (2007) Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation: the role of mu-calpain. Diabetes 56: 1842-1849.
4. Han J, Mandal AK, Hiebert LM, (2005) Endothelial cell injury by high glucose and heparanase is prevented by insulin, heparin and basic fibroblast growth factor. Cardiovasc Diabetol 4: 12.
5. Schalkwijk CG, Stehouwer CD, (2005) Vascular complications in diabetes mellitus: the role of endothelial dysfunction. Clin Sci (Lond) 109: 143-159.
6. Liu J, Wang R, Desai K, Wu L, (2011) Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome. Cardiovasc Res 92: 494-503.
7. Dhar A, Desai K, Kazachmov M, Yu P, Wu L, (2008) Methylglyoxal production in vascular smooth muscle cells from different metabolic precursors. Metabolism 57: 1211-1220.
8. Dhar A, Dhar I, Desai KM, Wu L, (2010) Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose. Br J Pharmacol 161: 1843-1856.
9. Phillips SA, Mirrlees D, Thornalley PJ, (1993) Modification of the glyoxalase system in streptozotocin-induced diabetic rats. Effect of the aldose reductase inhibitor Statil. Biochem Pharmacol 46: 805-811.
10. Shinohara M, Thornalley PJ, Giardino I, Beisswenger P, Thorpe SR, et al. (1998) Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis. J Clin Invest 101: 1142-1147.
11. Chang T, Wang R, Olson DJ, Mousseau DD, Ross AR, et al. (2011) Modification of Akt1 by methylglyoxal promotes the proliferation of vascular smooth muscle cells. FASEB J 25: 1746-1757.
12. Jia X, Olson DJ, Ross AR, Wu L, (2006) Structural and functional changes in human insulin induced by methylglyoxal. FASEB J 20: 1555-1557.
13. Wang X, Desai K, Clausen JT, Wu L, (2004) Increased methylglyoxal and advanced glycation end products in kidney from spontaneously hypertensive rats. Kidney Int 66: 2315-2321.
14. Mamputu JC, Renier G, (2002) Advanced glycation end products increase, through a protein kinase C-dependent pathway, vascular endothelial growth factor expression in retinal endothelial cells. Inhibitory effect of gliclazide. J Diabetes Complications 16: 284-293.
15. Thallas-Bonke V, Lindschau C, Rizkalla B, Bach LA, Boner G, et al. (2004) Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-alpha-dependent pathway. Diabetes 53: 2921-2930.
16. Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, et al. (2007) High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A. J Biol Chem 282: 31038-31045.
17. Morigi M, Angioletti S, Imberti B, Donadelli R, Micheletti G, et al. (1998) Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion. J Clin Invest 101: 1905-1915.
18. Ho FM, Lin WW, Chen BC, Chao CM, Yang CR, et al. (2006) High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway. Cell Signal 18: 391-399.
19. Bierhaus A, Chevion S, Chevion M, Hofmann M, Quehenberger P, et al. (1997) Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells. Diabetes 46: 1481-1490.
20. Wu L, Juurlink BH, (2002) Increased methylglyoxal and oxidative stress in hypertensive rat vascular smooth muscle cells. Hypertension 39: 809-814.
21. Desai K, Wu L, (2007) Methylglyoxal and advanced glycation endproducts: new therapeutic horizons? Recent Pat Cardiovasc Drug Discov 2: 89-99.
22. Edgell CJ, McDonald CC, Graham JB, (1983) Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci U S A 80: 3734-3737.
23. Riederer I, Sievert W, Eissner G, Molls M, Multhoff G, (2010) Irradiation-induced up-regulation of HLA-E on macrovascular endothelial cells confers protection against killing by activated natural killer cells. PLoS One 5: e15339.
24. O'Connor RP, Madison SD, Leveque P, Roderick HL, Bootman MD, (2010) Exposure to GSM RF fields does not affect calcium homeostasis in human endothelial cells, rat pheocromocytoma cells or rat hippocampal neurons. PLoS One 5: e11828.
25. Lim EJ, Smart EJ, Toborek M, Hennig B, (2007) The role of caveolin-1 in PCB77-induced eNOS phosphorylation in human-derived endothelial cells. Am J Physiol Heart Circ Physiol 293: H3340-3347.
26. Pfaffl MW, (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45.
27. Dhar A, Desai K, Liu J, Wu L, (2009) Methylglyoxal, protein binding and biological samples: are we getting the true measure? J Chromatogr B Analyt Technol Biomed Life Sci 877: 1093-1100.
28. Singh R, Barden A, Mori T, Beilin L, (2001) Advanced glycation end-products: a review. Diabetologia 44: 129-146.
29. Maeda H, Fukuyasu Y, Yoshida S, Fukuda M, Saeki K, et al. (2004) Fluorescent probes for hydrogen peroxide based on a non-oxidative mechanism. Angew Chem Int Ed Engl 43: 2389-2391.
30. Chang T, Wang R, Wu L, (2005) Methylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells. Free Radic Biol Med 38: 286-293.
31. Li Y, Bor YC, Misawa Y, Xue Y, Rekosh D, et al. (2006) An intron with a constitutive transport element is retained in a Tap messenger RNA. Nature 443: 234-237.
32. Cai H, Harrison DG, (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87: 840-844.
33. Nishizuka Y, (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258: 607-614.
34. Barnes PJ, Karin M, (1997) Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336: 1066-1071.
35. Goldin A, Beckman JA, Schmidt AM, Creager MA, (2006) Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation 114: 597-605.
36. Wautier JL, Zoukourian C, Chappey O, Wautier MP, Guillausseau PJ, et al. (1996) Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats. J Clin Invest 97: 238-243.
37. Wu L, (2005) The pro-oxidant role of methylglyoxal in mesenteric artery smooth muscle cells. Can J Physiol Pharmacol 83: 63-68.
38. Wang H, Liu J, Wu L, (2009) Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells. Biochem Pharmacol 77: 1709-1716.
39. Du XL, Edelstein D, Dimmeler S, Ju Q, Sui C, et al. (2001) Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J Clin Invest 108: 1341-1348.
40. Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, et al. (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404: 787-790.
41. Pieper GM, Riaz ul H, (1997) Activation of nuclear factor-kappaB in cultured endothelial cells by increased glucose concentration: prevention by calphostin C. J Cardiovasc Pharmacol 30: 528-532.
42. Phillips SA, Thornalley PJ, (1993) The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal. Eur J Biochem 212: 101-105.
43. Richard JP, (1993) Mechanism for the formation of methylglyoxal from triosephosphates. Biochem Soc Trans 21: 549-553.
44. Cox TM, (1994) Aldolase B and fructose intolerance. FASEB J 8: 62-71.
45. Chung SS, Chung SK, (2005) Aldose reductase in diabetic microvascular complications. Curr Drug Targets 6: 475-486.
46. Desai KM, Chang T, Wang H, Banigesh A, Dhar A, et al. (2010) Oxidative stress and aging: is methylglyoxal the hidden enemy? Can J Physiol Pharmacol 88: 273-284.
47. Yildiz G, Demiryurek AT, Sahin-Erdemli I, Kanzik I, (1998) Comparison of antioxidant activities of aminoguanidine, methylguanidine and guanidine by luminol-enhanced chemiluminescence. Br J Pharmacol 124: 905-910.
48. Park J, Kwon MK, Huh JY, Choi WJ, Jeong LS, et al. (2011) Renoprotective antioxidant effect of alagebrium in experimental diabetes. Nephrol Dial Transplant.