Fructose and uric acid: Is there a role in endothelial function?

Current Hypertension Reports

Volumn 16, Issue 6, 2014, Pages

  Jia, Guanghong ^a,b   Aroor, Annayya R ^a,b   Whaley Connell, Adam T ^a,b   Sowers, James R ^a,b  

^a University of Missouri   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cardiorenal metabolic syndrome; Estrogen; Hypertension; Inflammation; Insulin resistance; Lipogenesis; Nitric oxide; Oxidative stress

Indexed keywords

FRUCTOSE; URIC ACID; SWEETENING AGENT;

CARDIORENAL METABOLIC SYNDROME; CARDIORENAL SYNDROME; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; FRUCTOSE METABOLISM; HUMAN; HYPERURICEMIA; METABOLIC SYNDROME X; METABOLISM; NONHUMAN; REVIEW; URIC ACID BLOOD LEVEL; URIC ACID METABOLISM; CARDIO-RENAL SYNDROME; FEMALE; INSULIN RESISTANCE; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; VASCULAR ENDOTHELIUM;

CARDIO-RENAL SYNDROME; ENDOTHELIUM, VASCULAR; FEMALE; FRUCTOSE; HUMANS; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SWEETENING AGENTS; URIC ACID;

EID: 84905650438     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-014-0434-z     Document Type: Review

References (56)

1. Sheludiakova A, Rooney K, Boakes RA. Metabolic and behavioural effects of sucrose and fructose/glucose drinks in the rat. Eur J Nutr. 2012;51:445-54.
2. Lecoultre V, Egli L, Theytaz F, et al. Fructose-induced hyperuricemia is associated with a decreased renal uric acid excretion in humans. Diabetes Care. 2013;36:e149-50.
3. Lakhan SE, Kirchgessner A. The emerging role of dietary fructose in obesity and cognitive decline. Nutr J. 2013;12:114.
4. Cozma AI, Sievenpiper JL, de Souza RJ, et al. Effect of fructose on glycemic control in diabetes: a systematic review and meta-analysis of controlled feeding trials. Diabetes Care. 2012;35:1611-20.
5. Kretowicz M, Johnson RJ, Ishimoto T, et al. The impact of fructose on renal function and blood pressure. Int J Nephrol. 2011;2011: 315879.
6. Jindal A, Garcia-Touza M, Jindal N, et al. Diabetic kidney disease and the cardiorenal syndrome: old disease, new perspectives. Endocrinol Metab Clin N Am. 2013;42:789-808.
7. Tappy L, Lê KA. Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev. 2010;90:23-46.
8. Rajwani A, Cubbon RM, Wheatcroft SB. Cell-specific insulin resistance: implications for atherosclerosis. Diabetes Metab Res Rev. 2012;28:627-34.
9. Collino M. High dietary fructose intake: sweet or bitter life? World J Diabetes. 2011;2:77-81.
10. Samuel VT. Fructose induced lipogenesis: from sugar to fat to insulin resistance. Trends Endocrinol Metab. 2011;22:60-5.
11. Fushinobu S, Nishimasu H, Hattori D, et al. Structural basis for the bifunctionality of fructose -1,6-bisphosphate aldolase/phosphatase. Nature. 2011;478:538-41.
12. Johnson RJ, Sanchez-Lozada LG, Nakagawa T. The effect of fructose on renal biology and disease. J Am Soc Nephrol. 2010;21:2036-9.
13. Debosch BJ, Chen Z, Finck BN, et al. Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice. Mol Endocrinol. 2013;27: 1887-96.
14. Masterjohn C, Park Y, Lee J, et al. Dietary fructose feeding increases adipose methylglyoxal accumulation in rats in association with low expression and activity of glyoxalase-2. Nutrients. 2013;5: 3311-28.
15. Khitan Z, Kim DH. Fructose: a key factor in the development of metabolic syndrome and hypertension. J Nutr Metab. 2013;2013: 682673.
16. •• Johnson RJ, Nakagawa T, Sanchez-Lozada LG, et al. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes. 2013;62: 3307-15. This study showed the major discovery that fructose-mediated generation of uric acid may have a causal role in diabetes and obesity, and provides new insights into pathogenesis and therapies for this important disease.
17. • Sowers JR, Whaley-Connell A, Hayden MR. The role of overweight and obesity in the cardiorenal syndrome. Cardiorenal Med. 2011;1:5-12. This study revealed the potential mechanisms by which obesity and other metabolic abnormalities interact to promote heart and progressive kidney disease.
18. Dhar I, Dhar A, Wu L, Desai KM. Increased methylglyoxal formation with upregulation of Renin Angiotensin system in fructose fed sprague dawley rats. PLoS One. 2013;8:e74212.
19. Feinman RD, Fine EJ. Fructose in perspective. Nutr Metab (Lond). 2013;10:45.
20. Stanhope KL, Havel PJ. Fructose consumption: recent results and their potential implications. Ann N Y Acad Sci. 2010;1190:15-24.
21. •• Chaudhary K, Malhotra K, Sowers J, Aroor A. Uric acid - key ingredient in the recipe for cardiorenal metabolic syndrome. Cardiorenal Med. 2013;3:208-20. This study also found that elevated serum levels of uric acid appear to contribute to impaired nitric oxide production/endothelial dysfunction, increased vascular stiffness, inappropriate activation of the renin-angiotensinaldosterone system, enhanced oxidative stress, and maladaptive immune and inflammatory responses.
22. Sowers JR. Diabetes mellitus and vascular disease. Hypertension. 2013;61:943-7.
23. Aroor AR, McKarns S, Demarco VG, et al. Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance. Metabolism. 2013;62:1543-52.
24. So A, Thorens B. Uric acid transport and disease. J Clin Invest. 2010;120:1791-9.
25. Soltani Z, Rasheed K, Kapusta DR, Reisin E. Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal? Curr Hypertens Rev. 2013;15:175-81.
26. Jindal A, Brietzke S, Sowers JR. Obesity and the cardiorenal metabolic syndrome: therapeutic modalities and their efficacy in improving cardiovascular and renal risk factors. Cardiorenal Med. 2012;2:314-27.
27. Sluijs I, Beulens JW, van der Daphne AL, et al. Plasma uric acid is associated with increased risk of type 2 diabetes independent of diet and metabolic risk factors. J Nutr. 2013;143:80-5.
28. Johnson RJ, Perez-Pozo SE, Sautin YY, et al. Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev. 2009;30:96-116.
29. Santos RD. Elevated uric acid, the metabolic syndrome and cardiovascular disease: cause, consequence, or just a not so innocent bystander? Endocrine. 2012;41:350-2.
30. Zapolski T, Waciński P, Kondracki B, et al. Uric acid as a link between renal dysfunction and both pro-inflammatory and prothrombotic state in patients with metabolic syndrome and coronary artery disease. Kardiol Pol. 2011;69:319-26.
31. Baldwin W, McRae S, Marek G, et al. Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes. 2011;60: 1258-69.
32. Riegersperger M, Covic A, Goldsmith D. Allopurinol, uric acid, and oxidative stress in cardiorenal disease. Int Urol Nephrol. 2011;43:441-9.
33. Gul R, Demarco VG, Sowers JR, et al. Regulation of overnutritioninduced cardiac inflammatory mechanisms. Cardiorenal Med. 2012;2:225-33.
34. •• Muniyappa R, Sowers JR. Endothelial insulin and IGF-1 receptors: when yes means NO. Diabetes. 2012;61:2225-7. This report also revealed that interventions aimed at downregulating IGF-1R expression may augment endothelial insulin sensitivity in the pathological states.
35. Zhang Y, Sowers JR, Ren J. Pathophysiological insights into cardiovascular health in metabolic syndrome. Exp Diabetes Res. 2012;2012:320534.
36. Liu J, Shen W, Zhao B, et al. Targetingmitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: hope from natural mitochondrial nutrients. Adv Drug Deliv Rev. 2009;61:1343-52.
37. • Muniyappa R, Sowers JR. Role of insulin resistance in endothelial dysfunction. Rev Endocr Metab Disord. 2013;14:5-12. This study revealed the cellular mechanisms in the endothelium underlying vascular actions of insulin, the role of insulin resistance in mediating endothelial dysfunction, and the effect of insulin sensitizers in restoring the balance in pro- atherogenic and anti-atherogenic actions of insulin.
38. van Bussel BC, Schouten F, Henry RM, et al. Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period. Hypertension. 2011;58:588-95.
39. Ait-Oufella H, Salomon BL, Potteaux S, et al. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med. 2006;12:178-80. (Pubitemid 43214743)
40. He S, Li M, Ma X, et al. CD4 + CD25 + Foxp3+ regulatory T cells protect the proinflammatory activation of human umbilical vein endothelial cells. Arterioscler Thromb Vasc Biol. 2010;30:2621-30.
41. Garcia-Vargas L, Addison SS, Nistala R, et al. Gestational diabetes and the offspring: implications in the development of the cardiorenal metabolic syndrome in offspring. Cardiorenal Med. 2012;2:134-42.
42. Kim JA, Wei Y, Sowers JR. Role of mitochondrial dysfunction in insulin resistance. Circ Res. 2008;102:401-14. (Pubitemid 351651099)
43. • Kim JA, Jang HJ, Martinez-Lemus LA, Sowers JR. Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation. Am J Physiol Endocrinol Metab. 2012;302:E201-8. This report showed that Ang II-mediated impairment of vascular actions of insulin may help explain the role of Ang II as a link between insulin resistance and hypertension.
44. Bender SB, McGraw AP, Jaffe IZ, Sowers JR. Mineralocorticoid receptor-mediated vascular insulin resistance: an early contributor to diabetes-related vascular disease? Diabetes. 2013;62:313-9.
45. Mudau M, Genis A, Lochner A, Strijdom H. Endothelial dysfunction: the early predictor of atherosclerosis. Cardiovasc J Afr. 2012;23:222-31.
46. • Tran LT, Yuen VG, McNeill JH. The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension. Mol Cell Biochem. 2009;332:145-59. This study addressed the role of sympathetic nervous system overactivation, increased production of vasoconstrictors, such as endothelin-1 and angiotensin II, and prostanoids in the development of hypertension in fructose-fed rats.
47. • Manrique C, DeMarco VG, Aroor AR, et al. Obesity and insulin resistance induce early development of diastolic dysfunction in young female mice fed a Western diet. Endocrinology. 2013;154: 3632-42. This report also revealed that higher aldosterone levels, in concert with insulin resistance, may promote myocardial stiffness and diastolic dysfunction in response to overnutrition in females.
48. Galipeau D, Verma S, McNeill JH. Female rats are protected against fructose-induced changes in metabolism and blood pressure. Am J Physiol Heart Circ Physiol. 2002;283:H2478-84. (Pubitemid 35345953)
49. Song D, Arikawa E, Galipeau D, et al. Androgens are necessary for the development of fructose-induced hypertension. Hypertension. 2004;43:667-72. (Pubitemid 38282445)
50. Martins-Maciel ER, Campos LB, Salgueiro-Pagadigorria CL, et al. Raloxifene affects fatty acid oxidation in livers from ovariectomized rats by acting as a pro-oxidant agent. Toxicol Lett. 2013;217:82-9.
51. Manrique C, Lastra G, Habibi J, et al. Loss of estrogen receptor α signaling leads to insulin resistance and obesity in young and adult female mice. Cardiorenal Med. 2012;2:200-10.
52. O'Lone R, Knorr K, Jaffe IZ, et al. Estrogen receptors alpha and beta mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen species. Mol Endocrinol. 2007;21:1281-96. (Pubitemid 46991958)
53. Masood DE, Roach EC, Beauregard KG, Khalil RA. Impact of sex hormone metabolism on the vascular effects of menopausal hormone therapy in cardiovascular disease. Curr Drug Metab. 2010;11: 693-714.
54. Miller VM, Duckles SP. Vascular actions of estrogens: functional implications. Pharmacol Rev. 2008;60:210-41. (Pubitemid 351962010)
55. Lee SA, Kim EY, Jeon WK, et al. The inhibitory effect of raloxifene on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells is mediated through a ROS/p38 MAPK/CREB pathway to the up-regulation of heme oxygenase-1 independent of estrogen receptor. Biochimie. 2011;93:168-74.
56. Jaubert AM, Mehebik-Mojaat N, Lacasa D, et al. Nongenomic estrogen effects on nitric oxide synthase activity in rat adipocytes. Endocrinology. 2007;148:2444-52. (Pubitemid 46997057)