Long-term fructose feeding changes the expression of leptin receptors and autophagy genes in the adipose tissue and liver of male rats: A possible link to elevated triglycerides

Genes and Nutrition

Volumn 8, Issue 6, 2013, Pages 623-635

  Äijälä, Meiju ^a   Malo, Elina ^a   Ukkola, Olavi ^a   Bloigu, Risto ^a   Lehenkari, Petri ^a,b   Autio Harmainen, Helena ^a   Santaniemi, Merja ^a   Kesäniemi, Y Antero ^a  

^a UNIVERSITY OF OULU   (Finland)

^b OULU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Adipose tissue; Autophagy; Fructose; Leptin receptor; Liver

Indexed keywords

FRUCTOSE; LEPTIN; LEPTIN RECEPTOR; LEPTIN RECEPTOR A; LEPTIN RECEPTOR B; LEPTIN RECEPTOR C; LEPTIN RECEPTOR E; LEPTIN RECEPTOR F; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MESSENGER RNA; PROTEIN P62; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ACETYL COA CARBOXYLASE ALPHA GENE; ADIPOCYTE; ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY GENE; AUTOPHAGY RELATED GENE 7; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; INTRAUTERINE GROWTH RETARDATION; LIPID LIVER LEVEL; LIVER; LONG TERM EXPOSURE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2 GENE; MALE; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 BETA GENE; NONHUMAN; RAT; SUPPRESSOR OF CYTOKINE SIGNALING 3 GENE; TRIACYLGLYCEROL BLOOD LEVEL; WHITE ADIPOSE TISSUE;

EID: 84887215808     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-013-0357-3     Document Type: Article

References (34)

1. Andersen CL, Jensen JL, Orntoft TF (2004) Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res 64:5245-5250
2. Bjorbaek C, El-Haschimi K, Frantz JD, Flier JS (1999) The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem 274:30059-30065
3. Bjorkoy G, Lamark T, Pankiv S, Overvatn A, Brech A, Johansen T (2009) Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol 452:181-197
4. Briana DD, Malamitsi-Puchner A (2009) Intrauterine growth restriction and adult disease: the role of adipocytokines. Eur J Endocrinol 160:337-347
5. da Silveira Cavalcante F, Gombar FM, Ferreira RV, da Silva Faria T, Costa WS, Sampaio FJ, da Fonte Ramos C (2009) Maternal protein-energy and energy-restricted diets during lactation possibly could program folliculogenesis and the ovarian expression of leptin and its different isoform receptors in rats. Fertil Steril 92:1755-1757
6. Dekker MJ, Su Q, Baker C, Rutledge AC, Adeli K (2010) Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome. Am J Physiol Endocrinol Metab 299:E685-E694
7. Ezaki J, Matsumoto N, Takeda-Ezaki M, Komatsu M, Takahashi K, Hiraoka Y, Taka H, Fujimura T, Takehana K, Yoshida M, Iwata J, Tanida I, Furuya N, Zheng DM, Tada N, Tanaka K, Kominami E, Ueno T (2011) Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. Autophagy 7:727-736
8. Hagiwara S, Iwasaka H, Koga H, Hasegawa A, Kudo K, Kusaka J, Oyama Y, Noguchi T (2010) Stimulation of autophagy in the liver by lipopolysaccharide- induced systemic inflammation in a rat model of diabetes mellitus. Biomed Res 31:263-271
9. Hietaniemi M, Malo E, Jokela M, Santaniemi M, Ukkola O, Kesaniemi YA (2009) The effect of energy restriction during pregnancy on obesity-related peptide hormones in rat offspring. Peptides 30:705-709
10. Huan JN, Li J, Han Y, Chen K, Wu N, Zhao AZ (2003) Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. J Biol Chem 278:45638-45650
11. Jansen HJ, van Essen P, Koenen T, Joosten LA, Netea MG, Tack CJ, Stienstra R (2012) Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression. Endocrinology 153:5866-5874
12. Jaquet D, Deghmoun S, Chevenne D, Collin D, Czernichow P, Levy-Marchal C (2005) Dynamic change in adiposity from fetal to postnatal life is involved in the metabolic syndrome associated with reduced fetal growth. Diabetologia 48:849-855
13. Komatsu M (2012) Liver autophagy: physiology and pathology. J Biochem 152:5-15
14. Lukaszewski MA, Mayeur S, Fajardy I, Delahaye F, Dutriez-Casteloot I, Montel V, Dickes-Coopman A, Laborie C, Lesage J, Vieau D, Breton C (2011) Maternal prenatal undernutrition programs adipose tissue gene expression in adult male rat offspring under high-fat diet. Am J Physiol Endocrinol Metab 301:E548-E559
15. Malik SA, Marino G, BenYounes A, Shen S, Harper F, Maiuri MC, Kroemer G (2011) Neuroendocrine regulation of autophagy by leptin. Cell Cycle 10:2917-2923
16. Malo E, Saukko M, Santaniemi M, Hietaniemi M, Lammentausta E, Blanco Sequeiros R, Ukkola O, Kesaniemi YA (2013) Plasma lipid levels and body weight altered by intrauterine growth restriction and postnatal fructose diet in adult rats. Pediatr Res 73:155-162
17. Mao J, DeMayo FJ, Li H, Abu-Elheiga L, Gu Z, Shaikenov TE, Kordari P, Chirala SS, Heird WC, Wakil SJ (2006) Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Proc Natl Acad Sci USA 103:8552-8557
18. Mao J, Yang T, Gu Z, Heird WC, Finegold MJ, Lee B, Wakil SJ (2009) aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues. Proc Natl Acad Sci USA 106:17576-17581
19. Martinez-Beamonte R, Navarro MA, Larraga A, Strunk M, Barranquero C, Acin S, Guzman MA, Inigo P, Osada J (2011) Selection of reference genes for gene expression studies in rats. J Biotechnol 151:325-334
20. McMillen IC, Robinson JS (2005) Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev 85:571-633
21. Mizushima N, Yoshimori T (2007) How to interpret LC3 immunoblotting. Autophagy 3:542-545
22. Polyzos SA, Kountouras J, Zavos C, Deretzi G (2011) The potential adverse role of leptin resistance in nonalcoholic fatty liver disease: a hypothesis based on critical review of the literature. J Clin Gastroenterol 45:50-54
23. Rautou PE, Cazals-Hatem D, Moreau R, Francoz C, Feldmann G, Lebrec D, Ogier-Denis E, Bedossa P, Valla D, Durand F (2008) Acute liver cell damage in patients with anorexia nervosa: a possible role of starvation-induced hepatocyte autophagy. Gastroenterology 135:840-848, 848.e1-e3
24. Sengupta A, Molkentin JD, Yutzey KE (2009) FoxO transcription factors promote autophagy in cardiomyocytes. J Biol Chem 284:28319-28331
25. Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, Goto T, Westerbacka J, Sovijarvi A, Halavaara J, Yki-Jarvinen H (2002) Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87:3023-3028
26. Shapiro A, Mu W, Roncal C, Cheng KY, Johnson RJ, Scarpace PJ (2008) Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol 295:R1370-R1375
27. Shibata M, Yoshimura K, Furuya N, Koike M, Ueno T, Komatsu M, Arai H, Tanaka K, Kominami E, Uchiyama Y (2009) The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biochem Biophys Res Commun 382:419-423
28. Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ (2009a) Autophagy regulates lipid metabolism. Nature 458:1131-1135
29. Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Tang Y, Pessin JE, Schwartz GJ, Czaja MJ (2009b) Autophagy regulates adipose mass and differentiation in mice. J Clin Invest 119:3329-3339
30. Sparks JD, Sparks CE, Adeli K (2012) Selective hepatic insulin resistance, VLDL overproduction, and hypertriglyceridemia. Arterioscler Thromb Vasc Biol 32:2104-2112
31. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271
32. Wang MY, Grayburn P, Chen S, Ravazzola M, Orci L, Unger RH (2008) Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. Proc Natl Acad Sci USA 105:6139-6144
33. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
34. Zhang Y, Goldman S, Baerga R, Zhao Y, Komatsu M, Jin S (2009) Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci USA 106:19860-19865