Uric Acid Stimulates Fructokinase and Accelerates Fructose Metabolism in the Development of Fatty Liver

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Lanaspa, Miguel A ^a   Sanchez Lozada, Laura G ^a,b   Cicerchi, Christina ^a   Li, Nanxing ^a   Roncal Jimenez, Carlos A ^a   Ishimoto, Takuji ^a   Le, Myphuong ^a   Garcia, Gabriela E ^a   Thomas, Jeffrey B ^a   Rivard, Christopher J ^a   Andres Hernando, Ana ^a   Hunter, Brandi ^a   Schreiner, George ^c   Rodriguez Iturbe, Bernardo ^d   Sautin, Yuri Y ^e   Johnson, Richard J ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Laboratory of Renal Physiopathology and Department of Nephrology   (Mexico)

^c Cardero Therapeutics Incorporated   (United States)

^d UNIVERSIDAD DEL ZULIA   (Venezuela)

^e UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOKINASE; FRUCTOSE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CHREBP; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; URIC ACID;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVATION; ENZYME INDUCTION; FATTY LIVER; FRUCTOSE METABOLISM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPOGENESIS; LIVER CELL; MALE; METABOLIC RATE; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; RAT; TRANSCRIPTION INITIATION;

ALLOPURINOL; ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; ENZYME INHIBITORS; FATTY LIVER; FRUCTOKINASES; FRUCTOSE; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION; URIC ACID;

EID: 84868149993     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047948     Document Type: Article

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