Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 6, 2004, Pages 2963-2972

  Teff, Karen L ^a   Elliott, Sharon S ^b   Tschöp, Matthias ^d   Kieffer, Timothy J ^c   Rader, Daniel ^a   Heiman, Mark ^d   Townsend, Raymond R ^a   Keim, Nancy L ^e   D'Alessio, David ^f   Havel, Peter J ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d ELI LILLY AND COMPANY   (United States)

^e U S DEPARTMENT OF AGRICULTURE   (United States)

^f UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; FAT; FRUCTOSE; GHRELIN; GLUCOSE; INSULIN; LEPTIN; PROTEIN; TRIACYLGLYCEROL;

ADULT; AREA UNDER THE CURVE; BLOOD SAMPLING; CALORIC INTAKE; CARBOHYDRATE INTAKE; CIRCADIAN RHYTHM; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; DIETARY INTAKE; ENERGY BALANCE; FAT INTAKE; FEMALE; GLUCOSE BLOOD LEVEL; HORMONE INHIBITION; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESPONSE; NORMAL HUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN INTAKE; RANDOMIZATION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ADULT; BLOOD GLUCOSE; DIETARY CARBOHYDRATES; FATTY ACIDS, NONESTERIFIED; FEMALE; FRUCTOSE; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; HUMANS; INSULIN; LEPTIN; LIVER; PEPTIDE FRAGMENTS; PEPTIDE HORMONES; POSTPRANDIAL PERIOD; PROTEIN PRECURSORS; TRIGLYCERIDES;

EID: 2942638040     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-031855     Document Type: Conference Paper

References (68)

1. Havel PJ, Townsend R, Chaump L, Teff K 1999 High-fat meals reduce 24-h circulating leptin concentrations in women. Diabetes 48:334-341
2. Mueller WM, Gregoire FM, Stanhope KL, Mobbs CV, Mizuno TM, Warden CH, Stern JS, Havel PJ 1998 Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology 139:551-558
3. Havel PJ 2002 Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol 13:51-59
4. Porte Jr D, Baskin DG, Schwartz MW 2002 Leptin and insulin action in the central nervous system. Nutr Rev 60:S20-S29
5. Astrup A, Grunwald GK, Melanson EL, Saris WH, Hill JP 2000 The role of low-fat diets in body weight control: a meta-analysis of ad libitum dietary intervention studies. Int J Obes Relat Metab Disord 24:1545-1552
6. Havel PJ, Kasim-Karakas S, Mueller W, Johnson PR, Gingerich RL, Stern JS 1996 Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab 81:4406-4413
7. Curry DL 1989 Effects of mannose and fructose on the synthesis and secretion of insulin. Pancreas 4:2-9
8. Havel P 1997 Glucose but not fructose infusion increases circulating leptin in proportion to adipose stores in rhesus monkeys. Exp Clin Endocrinol Diabetes 105:37-38
9. Farooqi IS, Keogh JM, Kamath S, Jones S, Gibson WT, Trussel R, Jebb SA, Lip GT, O'Rahilly S 2001 Partial leptin deficiency and human adiposity. Nature 414:34-35
10. Weigle DS, Cummings DE, Newby PD, Breen PA, Frayo RS, Matthys CC, Callahan HS, Purnell JQ 2003 Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet. J Clin Endocrinol Metab 88:1577-1586
11. Putnam JJ, Allshouse JE 1999 Food consumption, prices and expenditures, 1970-1997. Washington, DC: U.S. Department of Agriculture, Economic Research Service
12. Kuczmarski RJ, Flegal KM, Campbell SM, Johnson CL 1994 Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991. JAMA 272:205-211
13. Grundy SM 1998 Multifactorial causation of obesity: implications for prevention. Am J Clin Nutr 67(Suppl 3):563S-572S
14. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR 2001 Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86:5992
15. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS 2001 A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714-1719
16. Beck B, Musse N, Stricker-Krongrad A 2002 Ghrelin, macronutrient intake and dietary preferences in Long-Evans rats. Biochem Biophys Res Commun 292:1031-1035
17. Lee HM, Wang G, Englander EW, Kojima M, Greeley Jr GH 2002 Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 143:185-190
18. Kong MF, Chapman I, Goble E, Wishart J, Wittert G, Morris H, Horowitz M 1999 Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects. Peptides 20:545-551
19. Vozzo R, Baker B, Wittert GA, Wishart JM, Morris H, Horowitz M, Chapman I 2002 Glycemic, hormone, and appetite responses to monosaccharide ingestion in patients with type 2 diabetes. Metabolism 51:949-957
20. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ 2002 Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76:911-922
21. Stunkard AJ, Messick S 1985 The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res 29:71-83
22. Mifflin MD, St Jeor ST, Hill LA, Scott BJ, Daugherty SA, Koh YO 1990 A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr 51:241-247
23. Lee HC, Curry DL, Stern JS 1993 Tonic sympathetic nervous system inhibition of insulin secretion is diminished in obese Zucker rats. Obes Res 1:371-376
24. Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS 2002 Elevated plasma ghrelin levels in Prader Willi syndrome. Nat Med 8:643-644
25. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ 2002 Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 346:1623-1630
26. Kuzio M, Dryburgh JR, Malloy KM, Brown JC 1974 Radioimmunoassay for gastric inhibitory polypeptide. Gastroenterology 66:357-364
27. Morgan LM, Morris BA, Marks V 1978 Radioimmunoassay of gastric inhibitory polypeptide. Ann Clin Biochem 15:172-177
28. Sato Y, Ito T, Udaka N, Kanisawa M, Noguchi Y, Cushman SW, Satoh S 1996 Immunohistochemical localization of facilitated-diffusion glucose transporters in rat pancreatic islets. Tissue Cell 28:637-643
29. Bantle JP, Laine DC, Castle GW, Thomas JW, Hoogwerf BJ, Goetz FC 1983 Postprandial glucose and insulin responses to meals containing different carbohydrates in normal and diabetic subjects. N Engl J Med 309:7-12
30. Havel P 2000 Role of adipose tissue in body weight regulation: mechanisms regulating leptin production and energy balance. Proc Nutr Soc 59:359-371
31. McCowen KC, Maykel JA, Bistrian BR, Ling PR 2002 Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents. J Endocrinol 175:R7-R11
32. Djurhuus CB, Hansen TK, Gravholt C, Orskov L, Hosoda H, Kangawa K, Jorgensen J, Holst JJ, Schmitz O 2002 Circulating levels of ghrelin and GLP-1 are inversely related during glucose ingestion. Horm Metab Res 34:411-413
33. Saad MF, Bernaba B, Hwu C, Jinagouda S, Fahmi S, Kogosov E, Boyadjian R 2002 Insulin regulates plasma ghrelin concentration. J Clin Endocrinol Metab 87:3997-4000
34. Flanagan DE, Evans ML, Monsod TP, Rife F, Heptulla RA, Tamborlane WV, Sherwin RS 2003 The influence of insulin on circulating ghrelin. Am J Physiol 284:E313-E316
35. Horvath TL, Diano S, Sotonyi P, Herman M, Tschop M 2001 Minireview: ghrelin and the regulation of energy balance - a hypothalamic perspective. Endocrinology 142:4163-4169
36. English P, Ghatei M, Malik I, Bloom S, Wilding J 2002 Food fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab 87:2984
37. DelParigi A, Tschop M, Heiman M, Salbe AD, Vozarova B, Sell SM, Bunt JC, Tataranni PA 2002 High circulating ghrelin: a potential cause for hyperphagia and obesity in Prader-Willi syndrome. J Clin Endocrinol Metab 87:5461-5464
38. Faraj M, Havel PJ, Phelis S, Blank D, Sniderman AD, Cianflone K 2003 Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. J Clin Endocrinol Metab 88:1594-1602
39. Moukarzel AA, Sabri MT 1996 Gastric physiology and function: effects of fruit juices. J Am Coll Nutr 15(Suppl 5):18S-25S
40. Pederson RA, Kieffer TJ, Pauly R, Kofod H, Kwong J, McIntosh CH 1996 The enteroinsular axis in dipeptidyl peptidase IV-negative rats. Metabolism 45: 1335-1341
41. Vahl T, D'Alessio D 2003 Enteroinsular signaling: perspectives on the role of the gastrointestinal hormones glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide in normal and abnormal glucose metabolism. Curr Opin Clin Nutr Metab Care 6:461-468
42. Drucker DJ 2002 Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology 122:531-544
43. Mayes PA 1993 Intermediary metabolism of fructose. Am J Clin Nutr 58(Suppl 5):754S-765S
44. Grant KI, Marais MP, Dhansay MA 1994 Sucrose in a lipid-rich meal amplifies the postprandial excursion of serum and lipoprotein triglyceride and cholesterol concentrations by decreasing triglyceride clearance. Am J Clin Nutr 59:853-860
45. Jeppesen J, Chen YI, Zhou MY, Schaaf P, Coulston A, Reaven GM 1995 Postprandial triglyceride and retinyl ester responses to oral fat: effects of fructose. Am J Clin Nutr 61:787-791
46. Bantle JP, Raatz SK, Thomas W, Georgopoulos A 2000 Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr 72:1128-1134
47. Raben A, Holst JJ, Madsen J, Astrup A 2001 Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high-fat diet in normal-weight never-obese and postobese women. Am J Clin Nutr 73:177-189
48. Hollenbeck CB 1993 Dietary fructose effects on lipoprotein metabolism and risk for coronary artery disease. Am J Clin Nutr 58(Suppl 5):800S-809S
49. Havel PJ, Elliott S, Keim NL, Rader D, Krauss R, Teff KL 2003 Short-term and long-term consumption of high fructose, but not high glucose diets, increases postprandial triglycerides and apo-lipoprotein-B in women. J Invest Med 51(Suppl 1):S163
50. Abraha A, Humphreys SM, Clark ML, Matthews DR, Frayn KN 1998 Acute effect of fructose on postprandial lipaemia in diabetic and non-diabetic subjects. Br J Nutr 80:169-175
51. Park YK, Yetley EA 1993 Intakes and food sources of fructose in the United states. Am J Clin Nutr 58(Suppl 5):727S-747S
52. Havel PJ 2001 Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis. Exp Biol Med 226:963-977
53. Tordoff MG, Alleva AM 1990 Effect of drinking soda sweetened with aspartame or high-fructose corn syrup on food intake and body weight. Am J Clin Nutr 51:963-969
54. Anderson JW, Story LJ, Zettwoch NC, Gustafson NJ, Jefferson BS 1989 Metabolic effects of fructose supplementation in diabetic individuals. Diabetes Care 12:337-344
55. Schwarz JM, Neese RA, Schakleton C, Hellerstein MK 1993 De novo lipogenesis during fasting and oral fructose ingestion in lean and obese hyperinsulinemic subjects. Diabetes 42(Suppl):A39 (Abstract)
56. Hellerstein MK, Schwarz JM, Neese RA 1996 Regulation of hepatic de novo lipogenesis in humans. Annu Rev Nutr 16:523-557
57. Harnack L, Stang J, Story M 1999 Soft drink consumption among US children and adolescents: nutritional consequences. J Am Diet Assoc 99:436-441
58. Ludwig DS, Peterson KE, Gortmaker SL 2001 Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. Lancet 357:505-508
59. Lluch A, Herberth B, Mejean L, Siest G 2000 Dietary intakes, earing style and overweight in the Stanislas Family Study. Int J Obes Relat Metab Disord 24:1493-1499
60. Laessle RG, Wurmser H, Pirke KM 2000 Restrained earing and leprin levels in overweight preadolescent girls. Physiol Behav 70:45-47
61. Hood MY, Moore LL, Sundarajan-Ramamurti A, Singer M, Cupples LA, Eddison RC 2000 Parental eating attitudes and the development of obesity in children. The Framingham Children's Study. Int J Obes Relat Metab Disord 24:1319-1325
62. Carper JL, Orlet FJ, Birch LL 2000 Young girls' emerging dietary restraint and disinhibition are related to parental control in child feeding. Appetite 5:121-129
63. Tuschl RJ, Laessle RG, Platte P, Pirke KM 1990 Differences in food-choice frequencies between restrained and unrestrained eaters. Appetite 14:9-13
64. Rogers PJ 1999 Eating habits and appetite control: a psychobiological perspective. Proc Nutr Soc 58:59-67
65. Greeno CG, Wing RR 1994 Stress-induced eating. Psychol Bull 115:444-464
66. Rodin J, Reed D, Jammer L 1988 Metabolic effects of fructose and glucose: implications for food intake. Am J Clin Nutr 47:683-689
67. Rodin J 1991 Effects of pure sugar vs. mixed starch fructose loads on food intake. Appetite 17:213-219
68. Havel PJ 2004 Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism. Diabetes 53(Suppl 1):S143-151