메뉴 건너뛰기




Volumn 14, Issue 3, 2003, Pages 137-145

The adipocyte in insulin resistance: Key molecules and the impact of the thiazolidinediones

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; ANTIDIABETIC AGENT; FATTY ACID; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; RESISTIN; ROSIGLITAZONE; THIAZOLIDINE DERIVATIVE; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0037732481     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(03)00024-9     Document Type: Review
Times cited : (358)

References (65)
  • 1
    • 0035850402 scopus 로고    scopus 로고
    • The continuing epidemics of obesity and diabetes in the United States
    • Mokdad, A.H. et al. (2001) The continuing epidemics of obesity and diabetes in the United States. J. Am. Med. Assoc. 286, 1195-1200
    • (2001) J. Am. Med. Assoc. , vol.286 , pp. 1195-1200
    • Mokdad, A.H.1
  • 2
    • 0033864648 scopus 로고    scopus 로고
    • Diabetes trends in the U.S.: 1990-1998
    • Mokdad, A.H. et al. (2000) Diabetes trends in the U.S.: 1990-1998. Diabetes Care 23, 1278-1283
    • (2000) Diabetes Care , vol.23 , pp. 1278-1283
    • Mokdad, A.H.1
  • 3
    • 0036582654 scopus 로고    scopus 로고
    • The rising prevalence of diabetes and impaired glucose tolerance: The Australian Diabetes, Obesity and Lifestyle Study
    • Dunstan, D.W. et al. (2002) The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care 25, 829-834
    • (2002) Diabetes Care , vol.25 , pp. 829-834
    • Dunstan, D.W.1
  • 4
    • 0035512752 scopus 로고    scopus 로고
    • Childhood obesity: The health issue
    • Deckelbaum, R.J. and Williams, C.L. (2001) Childhood obesity: the health issue. Obes. Res. 9, 239S-243S
    • (2001) Obes. Res. , vol.9
    • Deckelbaum, R.J.1    Williams, C.L.2
  • 5
    • 0037076040 scopus 로고    scopus 로고
    • Childhood obesity and a diabetes epidemic
    • Rocchini, A.P. (2002) Childhood obesity and a diabetes epidemic. N. Engl. J. Med. 346, 854-855
    • (2002) N. Engl. J. Med. , vol.346 , pp. 854-855
    • Rocchini, A.P.1
  • 6
    • 0015698908 scopus 로고
    • Endocrine and metabolic effects of experimental obesity in man
    • Sims, E.A. et al. (1973) Endocrine and metabolic effects of experimental obesity in man. Recent Prog. Horm. Res. 29, 457-496
    • (1973) Recent Prog. Horm. Res. , vol.29 , pp. 457-496
    • Sims, E.A.1
  • 7
    • 0018373044 scopus 로고
    • Normalization of the insulin sensitivity and the cellular insulin binding during treatment of obese diabetics for one year
    • Beck-Nielsen, H. et al. (1979) Normalization of the insulin sensitivity and the cellular insulin binding during treatment of obese diabetics for one year. Acta Endocrinol. (Copenh.) 90, 103-112
    • (1979) Acta Endocrinol. (Copenh.) , vol.90 , pp. 103-112
    • Beck-Nielsen, H.1
  • 8
    • 0023798487 scopus 로고
    • Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss
    • Freidenberg, G.R. et al. (1988) Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss. J. Clin. Invest. 82, 1398-1406
    • (1988) J. Clin. Invest , vol.82 , pp. 1398-1406
    • Freidenberg, G.R.1
  • 9
    • 0026651566 scopus 로고
    • In vivo insulin action and muscle glycogen synthase activity in type 2 (non-insulin-dependent) diabetes mellitus: Effects of diet treatment
    • Bak, J.F. et al. (1992) In vivo insulin action and muscle glycogen synthase activity in type 2 (non-insulin-dependent) diabetes mellitus: effects of diet treatment. Diabetologia 35, 777-784
    • (1992) Diabetologia , vol.35 , pp. 777-784
    • Bak, J.F.1
  • 10
    • 0026590484 scopus 로고
    • Pathogenesis of NIDDM. A balanced overview
    • DeFronzo, R.A. et al. (1992) Pathogenesis of NIDDM. A balanced overview. Diabetes Care 15, 318-368
    • (1992) Diabetes Care , vol.15 , pp. 318-368
    • DeFronzo, R.A.1
  • 11
    • 0033694663 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance and the role of the adipocyte
    • Hotamisligil, G.S. (2000) Molecular mechanisms of insulin resistance and the role of the adipocyte. Int. J. Obes. Relat. Metab. Disord. 24, S23-S27
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24
    • Hotamisligil, G.S.1
  • 12
    • 0035145593 scopus 로고    scopus 로고
    • Central role of the adipocyte in the metabolic syndrome
    • Bergman, R.N. et al. (2001) Central role of the adipocyte in the metabolic syndrome. J. Investig. Med. 49, 119-126
    • (2001) J. Investig. Med. , vol.49 , pp. 119-126
    • Bergman, R.N.1
  • 13
    • 0030657602 scopus 로고    scopus 로고
    • Regional adipocity in man
    • Arner, P. (1997) Regional adipocity in man. J. Endocrinol. 155, 191-192
    • (1997) J. Endocrinol. , vol.155 , pp. 191-192
    • Arner, P.1
  • 14
    • 0034890103 scopus 로고    scopus 로고
    • Physiological role of adipose tissue: White adipose tissue as an endocrine and secretory organ
    • Trayhurn, P. and Beattie, J.H. (2001) Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc. Nutr. Soc. 60, 329-339
    • (2001) Proc. Nutr. Soc. , vol.60 , pp. 329-339
    • Trayhurn, P.1    Beattie, J.H.2
  • 15
    • 0002861937 scopus 로고    scopus 로고
    • Free fatty acids - Do they play a central role in type 2 diabetes?
    • Arner, P. (2001) Free fatty acids - do they play a central role in type 2 diabetes? Diabetes Obes. Metab. 3, 11-19
    • (2001) Diabetes Obes. Metab. , vol.3 , pp. 11-19
    • Arner, P.1
  • 16
    • 0036615436 scopus 로고    scopus 로고
    • Molecular insights into insulin action and secretion
    • Rhodes, C.J. and White, M.F. (2002) Molecular insights into insulin action and secretion. Eur. J. Clin. Invest. 32, 3-13
    • (2002) Eur. J. Clin. Invest. , vol.32 , pp. 3-13
    • Rhodes, C.J.1    White, M.F.2
  • 17
    • 0033849777 scopus 로고    scopus 로고
    • Obesity and insulin resistance
    • Kahn, B.B. and Flier, J.S. (2000) Obesity and insulin resistance. J. Clin. Invest. 106, 473-481
    • (2000) J. Clin. Invest. , vol.106 , pp. 473-481
    • Kahn, B.B.1    Flier, J.S.2
  • 19
    • 0032762661 scopus 로고    scopus 로고
    • Insulin signaling and action in fat cells: Associations with insulin resistance and type 2 diabetes
    • Smith, U. et al. (1999) Insulin signaling and action in fat cells: associations with insulin resistance and type 2 diabetes. Ann. New York Acad. Sci. 892, 119-126
    • (1999) Ann. New York Acad. Sci. , vol.892 , pp. 119-126
    • Smith, U.1
  • 21
    • 0342265155 scopus 로고    scopus 로고
    • Secretion of tumor necrosis factor-α shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue
    • Löfgren, P. et al. (2000) Secretion of tumor necrosis factor-α shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue. Diabetes 49, 688-692
    • (2000) Diabetes , vol.49 , pp. 688-692
    • Löfgren, P.1
  • 22
    • 0036616582 scopus 로고    scopus 로고
    • Identifying the links between obesity, insulin resistance and β-cell function: Potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes
    • Greenberg, A.S. and McDaniel, M.L. (2002) Identifying the links between obesity, insulin resistance and β-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes. Eur. J. Clin. Invest. 32, 24-34
    • (2002) Eur. J. Clin. Invest. , vol.32 , pp. 24-34
    • Greenberg, A.S.1    McDaniel, M.L.2
  • 23
    • 0032779156 scopus 로고    scopus 로고
    • Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM
    • Carvalho, E. et al. (1999) Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM. FASEB J. 13, 2173-2178
    • (1999) FASEB J. , vol.13 , pp. 2173-2178
    • Carvalho, E.1
  • 24
    • 0036254607 scopus 로고    scopus 로고
    • Insulin resistance in type 2 diabetes: Role of fatty acids
    • Arner, P. (2002) Insulin resistance in type 2 diabetes: role of fatty acids. Diabetes Metab. Res. Rev. 18, S5-S9
    • (2002) Diabetes Metab. Res. Rev. , vol.18
    • Arner, P.1
  • 25
    • 8844255630 scopus 로고    scopus 로고
    • Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and β-cell dysfunction
    • Boden, G. and Shulman, G.I. (2002) Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β-cell dysfunction. Eur. J. Clin. Invest. 32, 14-23
    • (2002) Eur. J. Clin. Invest. , vol.32 , pp. 14-23
    • Boden, G.1    Shulman, G.I.2
  • 26
    • 0036296673 scopus 로고    scopus 로고
    • Insulin action in skeletal muscle: Isozyme-specific effects of protein kinase C
    • Idris, I. et al. (2002) Insulin action in skeletal muscle: isozyme-specific effects of protein kinase C. Ann. New York Acad. Sci. 967, 176-182
    • (2002) Ann. New York Acad. Sci. , vol.967 , pp. 176-182
    • Idris, I.1
  • 27
    • 0036296672 scopus 로고    scopus 로고
    • Skeletal muscle triglycerides: An aspect of regional adiposity and insulin resistance
    • Kelley, D.E. (2002) Skeletal muscle triglycerides: an aspect of regional adiposity and insulin resistance. Ann. New York Acad. Sci. 967, 135-145
    • (2002) Ann. New York Acad. Sci. , vol.967 , pp. 135-145
    • Kelley, D.E.1
  • 28
    • 0035985669 scopus 로고    scopus 로고
    • New factors in the regulation of adipose differentiation and metabolism
    • Holst, D. and Grimaldi, P.A. (2002) New factors in the regulation of adipose differentiation and metabolism. Curr. Opin. Lipidol. 13, 241-245
    • (2002) Curr. Opin. Lipidol. , vol.13 , pp. 241-245
    • Holst, D.1    Grimaldi, P.A.2
  • 29
    • 0035905758 scopus 로고    scopus 로고
    • The hormone resistin links obesity to diabetes
    • Steppan, C.M. et al. (2001) The hormone resistin links obesity to diabetes. Nature 409, 307-312
    • (2001) Nature , vol.409 , pp. 307-312
    • Steppan, C.M.1
  • 30
    • 0030821976 scopus 로고    scopus 로고
    • Is leptin the link between obesity and insulin resistance?
    • Girard, J. (1997) Is leptin the link between obesity and insulin resistance? Diabetes Metab. 23, 16-24
    • (1997) Diabetes Metab. , vol.23 , pp. 16-24
    • Girard, J.1
  • 32
    • 0036228581 scopus 로고    scopus 로고
    • The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: Distinct metabolic effects of two fat compartments
    • Cnop, M. et al. (2002) The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: distinct metabolic effects of two fat compartments. Diabetes 51, 1005-1015
    • (2002) Diabetes , vol.51 , pp. 1005-1015
    • Cnop, M.1
  • 33
    • 0031898610 scopus 로고    scopus 로고
    • PPAR-γ: Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman, B.M. (1998) PPAR-γ: adipogenic regulator and thiazolidinedione receptor. Diabetes 47, 507-514
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 34
    • 0036189407 scopus 로고    scopus 로고
    • PPARadigms and PPARadoxes. Expanding roles for PPARγ in the control of lipid metabolism
    • Walczak, R. and Tontonoz, P. (2002) PPARadigms and PPARadoxes. Expanding roles for PPARγ in the control of lipid metabolism. J. Lipid Res. 43, 177-186
    • (2002) J. Lipid Res. , vol.43 , pp. 177-186
    • Walczak, R.1    Tontonoz, P.2
  • 35
    • 0037016773 scopus 로고    scopus 로고
    • Ligands of peroxisome proliferatoractivated receptor-γ block activation of pancreatic stellate cells
    • Masamune, A. et al. (2002) Ligands of peroxisome proliferatoractivated receptor-γ block activation of pancreatic stellate cells. J. Biol. Chem. 277, 141-147
    • (2002) J. Biol. Chem. , vol.277 , pp. 141-147
    • Masamune, A.1
  • 36
    • 0036250329 scopus 로고    scopus 로고
    • Differentiating members of the thiazolidinedione class: A focus on safety
    • Lebovitz, H.E. (2002) Differentiating members of the thiazolidinedione class: a focus on safety. Diabetes Metab. Res. Rev. 18 (Suppl. 2), S23-S29
    • (2002) Diabetes Metab. Res. Rev. , vol.18 , Issue.SUPPL. 2
    • Lebovitz, H.E.1
  • 37
    • 0035140430 scopus 로고    scopus 로고
    • Rosiglitazone monotherapy is effective in patients with type 2 diabetes
    • Lebovitz, H.E. et al. (2001) Rosiglitazone monotherapy is effective in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 86, 280-288
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 280-288
    • Lebovitz, H.E.1
  • 38
    • 0036517099 scopus 로고    scopus 로고
    • Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes
    • Miyazaki, Y. et al. (2002) Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes. Diabetes Care 25, 517-523
    • (2002) Diabetes Care , vol.25 , pp. 517-523
    • Miyazaki, Y.1
  • 39
    • 17544396164 scopus 로고    scopus 로고
    • Activators of peroxisome proliferator-activated receptor γ have depot-specific effects on human preadipocyte differentiation
    • Adams, M. et al. (1997) Activators of peroxisome proliferator-activated receptor γ have depot-specific effects on human preadipocyte differentiation. J. Clin. Invest. 100, 3149-3153
    • (1997) J. Clin. Invest. , vol.100 , pp. 3149-3153
    • Adams, M.1
  • 40
    • 0036300137 scopus 로고    scopus 로고
    • Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes
    • Van Harmelen, V. et al. (2002) Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes. Diabetes 51, 2029-2036
    • (2002) Diabetes , vol.51 , pp. 2029-2036
    • Van Harmelen, V.1
  • 41
    • 0001922502 scopus 로고    scopus 로고
    • Comparative effects of rosiglitazone and metformin on fatty liver and visceral adiposity in type 2 diabetes mellitus
    • Kelley, D.E. et al. (2002) Comparative effects of rosiglitazone and metformin on fatty liver and visceral adiposity in type 2 diabetes mellitus. Diabetes 51, A35
    • (2002) Diabetes , vol.51
    • Kelley, D.E.1
  • 42
    • 0012522090 scopus 로고    scopus 로고
    • Different effects of rosiglitazone and metformin on adipose tissue glucose uptake in type 2 diabetes
    • Virtanen, K.A. et al. (2002) Different effects of rosiglitazone and metformin on adipose tissue glucose uptake in type 2 diabetes. Diabetes 51, A145
    • (2002) Diabetes , vol.51
    • Virtanen, K.A.1
  • 43
    • 0000403839 scopus 로고    scopus 로고
    • Rosiglitazone selectively increases subcutaneous but not visceral adipose tissue mass in type 2 diabetes mellitus
    • Banerji, M. et al. (2001) Rosiglitazone selectively increases subcutaneous but not visceral adipose tissue mass in type 2 diabetes mellitus. Diabetes 50, A90
    • (2001) Diabetes , vol.50
    • Banerji, M.1
  • 44
    • 0036343675 scopus 로고    scopus 로고
    • Rosiglitazone: A review of its use in the management of type 2 diabetes mellitus
    • Wagstaff, A.J. and Goa, K.L. (2002) Rosiglitazone: a review of its use in the management of type 2 diabetes mellitus. Drugs 62, 1805-1837
    • (2002) Drugs , vol.62 , pp. 1805-1837
    • Wagstaff, A.J.1    Goa, K.L.2
  • 45
    • 0036319163 scopus 로고    scopus 로고
    • Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro
    • McTernan, P.G. et al. (2002) Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro. Diabetes 51, 1493-1498
    • (2002) Diabetes , vol.51 , pp. 1493-1498
    • McTernan, P.G.1
  • 46
    • 0037940864 scopus 로고    scopus 로고
    • Comparative study of the effects of rosiglitazone and pioglitazone on interferon, tumor necrosis factor, interleukin-1, interleukin-4, interleukin-6 and C-reactive protein in diabetic patients with atherosclerosis
    • Tan, S.A. et al. (2002) Comparative study of the effects of rosiglitazone and pioglitazone on interferon, tumor necrosis factor, interleukin-1, interleukin-4, interleukin-6 and C-reactive protein in diabetic patients with atherosclerosis. Diabetes 51, A595
    • (2002) Diabetes , vol.51
    • Tan, S.A.1
  • 47
    • 0034607438 scopus 로고    scopus 로고
    • Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: A randomized controlled trial
    • Fonseca, V. et al. (2000) Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: a randomized controlled trial. J. Am. Med. Assoc. 283, 1695-1702
    • (2000) J. Am. Med. Assoc. , vol.283 , pp. 1695-1702
    • Fonseca, V.1
  • 48
    • 0033975057 scopus 로고    scopus 로고
    • Addition of low-dose rosiglitazone to sulphonylurea therapy improves glycaemic control in type 2 diabetic patients
    • Wolffenbuttel, B.H. et al. (2000) Addition of low-dose rosiglitazone to sulphonylurea therapy improves glycaemic control in type 2 diabetic patients. Diabet. Med. 17, 40-47
    • (2000) Diabet. Med. , vol.17 , pp. 40-47
    • Wolffenbuttel, B.H.1
  • 49
    • 0002103003 scopus 로고    scopus 로고
    • PPARγ agonists in type 2 diabetes: How far have we come from 'preventing the inevitable'? A review of the metabolic effects of rosiglitazone
    • Zinman, B. (2001) PPARγ agonists in type 2 diabetes: how far have we come from 'preventing the inevitable'? A review of the metabolic effects of rosiglitazone. Diabetes Obes. Metab. 3, S34-S43
    • (2001) Diabetes Obes. Metab. , vol.3
    • Zinman, B.1
  • 50
    • 0036310037 scopus 로고    scopus 로고
    • The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
    • Mayerson, A.B. et al. (2002) The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes 51, 797-802
    • (2002) Diabetes , vol.51 , pp. 797-802
    • Mayerson, A.B.1
  • 51
    • 0036481709 scopus 로고    scopus 로고
    • Synthetic peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients
    • Yang, W.S. et al. (2002) Synthetic peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients. Diabetes Care 25, 376-380
    • (2002) Diabetes Care , vol.25 , pp. 376-380
    • Yang, W.S.1
  • 52
    • 0036860896 scopus 로고    scopus 로고
    • Atherosclerosis in type 2 diabetes and insulin resistance: Mechanistic links and therapeutic targets
    • Plutzky, J. et al. (2002) Atherosclerosis in type 2 diabetes and insulin resistance: mechanistic links and therapeutic targets. J. Diabetes Comp. 16, 401-415
    • (2002) J. Diabetes Comp. , vol.16 , pp. 401-415
    • Plutzky, J.1
  • 53
    • 0037205499 scopus 로고    scopus 로고
    • Mechanisms regulating adipocyte expression of resistin
    • Hartman, H.B. et al. (2002) Mechanisms regulating adipocyte expression of resistin. J. Biol. Chem. 277, 19754-19761
    • (2002) J. Biol. Chem. , vol.277 , pp. 19754-19761
    • Hartman, H.B.1
  • 54
    • 85031148489 scopus 로고    scopus 로고
    • The regulation of resistin expression by insulin and rosiglitazone in human abdominal subcutaneous adipocytes
    • McTernan, P.G. et al. (2002) The regulation of resistin expression by insulin and rosiglitazone in human abdominal subcutaneous adipocytes. Diabetes 51, A88
    • (2002) Diabetes , vol.51
    • McTernan, P.G.1
  • 55
    • 0036357515 scopus 로고    scopus 로고
    • Resistin - Resistant to defining its role
    • Smith, U. (2002) Resistin - resistant to defining its role. Obes. Res. 10, 61-62
    • (2002) Obes. Res. , vol.10 , pp. 61-62
    • Smith, U.1
  • 56
    • 0014971569 scopus 로고
    • Comparative aspects of lipogenesis in mammalian tissues
    • Shrago, E. et al. (1971) Comparative aspects of lipogenesis in mammalian tissues. Metabolism 20, 54-62
    • (1971) Metabolism , vol.20 , pp. 54-62
    • Shrago, E.1
  • 57
    • 0031240956 scopus 로고    scopus 로고
    • Adrenergic regulation of adipocyte metabolism
    • Lafontan, M. et al. (1997) Adrenergic regulation of adipocyte metabolism. Hum. Reprod. 12, 6-20
    • (1997) Hum. Reprod. , vol.12 , pp. 6-20
    • Lafontan, M.1
  • 58
    • 0036460322 scopus 로고    scopus 로고
    • Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans
    • Björnholm, M. et al. (2002) Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans. Diabetologia 45, 1697-1702
    • (2002) Diabetologia , vol.45 , pp. 1697-1702
    • Björnholm, M.1
  • 59
    • 0030735542 scopus 로고    scopus 로고
    • Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo
    • Mohamed-Ali, V. et al. (1997) Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. J. Clin. Endocrinol. Metab. 82, 4196-4200
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 4196-4200
    • Mohamed-Ali, V.1
  • 60
    • 0037059777 scopus 로고    scopus 로고
    • Mapping of early signaling events in tumor necrosis factor-α-mediated lipolysis in human fat cells
    • Rydén, M. et al. (2002) Mapping of early signaling events in tumor necrosis factor-α-mediated lipolysis in human fat cells. J. Biol. Chem. 277, 1085-1091
    • (2002) J. Biol. Chem. , vol.277 , pp. 1085-1091
    • Rydén, M.1
  • 61
    • 0030671444 scopus 로고    scopus 로고
    • Species-specific alternative splicing generates a catalytically inactive form of human hormone-sensitive lipase
    • Laurell, H. et al. (1997) Species-specific alternative splicing generates a catalytically inactive form of human hormone-sensitive lipase. Biochem. J. 328, 137-143
    • (1997) Biochem. J. , vol.328 , pp. 137-143
    • Laurell, H.1
  • 62
    • 0036063941 scopus 로고    scopus 로고
    • A unique defect in the regulation of visceral fat cell lipolysis in the polycystic ovary syndrome as an early link to insulin resistance
    • Ek, I. et al. (2002) A unique defect in the regulation of visceral fat cell lipolysis in the polycystic ovary syndrome as an early link to insulin resistance. Diabetes 51, 484-492
    • (2002) Diabetes , vol.51 , pp. 484-492
    • Ek, I.1
  • 63
    • 0031771002 scopus 로고    scopus 로고
    • Brown adipose tissue. More than an effector of thermogenesis?
    • Cannon, B. et al. (1998) Brown adipose tissue. More than an effector of thermogenesis? Ann. New York Acad. Sci. 856, 171-187
    • (1998) Ann. New York Acad. Sci. , vol.856 , pp. 171-187
    • Cannon, B.1
  • 64
    • 0032474246 scopus 로고    scopus 로고
    • Not all fat is alike
    • Arner, P. (1998) Not all fat is alike. Lancet 351, 1301-1302
    • (1998) Lancet , vol.351 , pp. 1301-1302
    • Arner, P.1
  • 65
    • 0036373357 scopus 로고    scopus 로고
    • Insulin signal transduction and glucose transport in human adipocytes: Effects of obesity and low calorie diet
    • Björnholm, M. et al. (2002) Insulin signal transduction and glucose transport in human adipocytes: effects of obesity and low calorie diet. Diabetologia 45, 1128-1135
    • (2002) Diabetologia , vol.45 , pp. 1128-1135
    • Björnholm, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.