Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles from Hepatocytes

Gastroenterology

Volumn 150, Issue 4, 2016, Pages 956-967

  Hirsova, Petra ^a   Ibrahim, Samar H ^a   Krishnan, Anuradha ^a   Verma, Vikas K ^a   Bronk, Steven F ^a   Werneburg, Nathan W ^a   Charlton, Michael R ^b   Shah, Vijay H ^a   Malhi, Harmeet ^a   Gores, Gregory J ^a  

^a MAYO CLINIC   (United States)

^b INTERMOUNTAIN MEDICAL CENTER   (United States)

Author keywords

Cell Death; Exosomes; Lipotoxic; Microvesicles

Indexed keywords

ALANINE AMINOTRANSFERASE; DEATH RECEPTOR 5; FASUDIL; INTERLEUKIN 1BETA; INTERLEUKIN 6; LYSOPHOSPHATIDYLCHOLINE; MESSENGER RNA; PALMITIC ACID; RHO ASSOCIATED COILED COIL CONTAINING PROTEIN KINASE 1; RHO KINASE; UNCLASSIFIED DRUG; AUTACOID; CASPASE; PROTEIN KINASE INHIBITOR; ROCK1 PROTEIN, HUMAN; ROCK1 PROTEIN, MOUSE; TNFRSF10B PROTEIN, HUMAN; TNFRSF10B PROTEIN, MOUSE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CELLULAR SECRETION; CONTROLLED STUDY; ENZYME INHIBITION; EXOSOME; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIPOTOXICITY; LIVER CELL; MACROPHAGE ACTIVATION; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG EFFECTS; EXPERIMENTAL LIVER CIRRHOSIS; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HEPATITIS; LIVER; MACROPHAGE; METABOLISM; NON-ALCOHOLIC FATTY LIVER DISEASE; PATHOLOGY; PHENOTYPE; RNA INTERFERENCE; SPRAGUE DAWLEY RAT; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; CASPASES; CELL LINE, TUMOR; EXTRACELLULAR VESICLES; HEK293 CELLS; HEPATITIS; HEPATOCYTES; HUMANS; INFLAMMATION MEDIATORS; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; LYSOPHOSPHATIDYLCHOLINES; MACROPHAGES; MICE, INBRED C57BL; MICE, TRANSGENIC; NON-ALCOHOLIC FATTY LIVER DISEASE; PALMITIC ACID; PHENOTYPE; PROTEIN KINASE INHIBITORS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RHO-ASSOCIATED KINASES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84975747692     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.12.037     Document Type: Article

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