Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c

Diabetes

Volumn 55, Issue 7, 2006, Pages 2032-2041

  Biddinger, Sudha B ^a,b,c   Miyazaki, Makoto ^d   Boucher, Jeremie ^a,b   Ntambi, James M ^d   Kahn, C Ronald ^a,b  

^a JOSLIN DIABETES CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

ACC, acetyl CoA carboxylase; CNS, central nervous system; IRS, insulin receptor substrate; LXR, liver X receptor; MCH, melanin concentrating hormone; MUFA, monounsaturated fatty acid; SCD, stearoyl CoA desaturase; SFA, saturated fatty acid; SREBP

Indexed keywords

ACYL COENZYME A DESATURASE; INSULIN; INSULIN RECEPTOR; LEPTIN; MONOUNSATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; PRIMER DNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REPRESSION; FATTY ACID SYNTHESIS; GENE EXPRESSION; HYPERINSULINEMIA; KNOCKOUT GENE; LIPID COMPOSITION; LIVER; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BLOOD; BODY WEIGHT; CALORIC INTAKE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; GLUCOSE BLOOD LEVEL; METABOLISM; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

ANIMALS; BASE SEQUENCE; BLOOD GLUCOSE; BODY WEIGHT; DNA PRIMERS; ENERGY INTAKE; INSULIN; LEPTIN; MICE; MICE, KNOCKOUT; MICE, OBESE; POLYMERASE CHAIN REACTION; RECEPTOR, INSULIN; STEAROYL-COA DESATURASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 33747034520     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-0742     Document Type: Article

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