Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome

Cardiovascular Research

Volumn 92, Issue 3, 2011, Pages 494-503

  Liu, Jianghai ^a   Wang, Rui ^b   Desai, Kaushik ^a   Wu, Lingyun ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b LAKEHEAD UNIVERSITY   (Canada)

Author keywords

Aldolase B; Fructose; Metabolic syndrome; Methylglyoxal

Indexed keywords

ALDEHYDE REDUCTASE; ALDOLASE B; AMINE OXIDASE (COPPER CONTAINING); CYTOCHROME P450 2E1; FRUCTOKINASE; FRUCTOSE; FRUCTOSE BISPHOSPHATE ALDOLASE; FRUCTOSE BISPHOSPHATE ALDOLASE ISOENZYME; GLUCOSE; GLUCOSE TRANSPORTER 5; INSULIN; METHYLGLYOXAL; POLYOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE MODEL; GENE EXPRESSION; GENE SILENCING; GLYCOLYSIS; HYPERGLYCEMIA; HYPERTENSION; LIPID METABOLISM; MALE; METABOLIC SYNDROME X; NONHUMAN; OBESE NON DIABETIC ZUCKER RAT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; RAT; SMOOTH MUSCLE FIBER; SPONTANEOUSLY HYPERTENSIVE RAT; UPREGULATION; VASCULAR SMOOTH MUSCLE; VASCULAR SMOOTH MUSCLE CELL; VASCULAR TISSUE; ZUCKER DIABETIC FATTY RAT; ZUCKER RAT;

ALDEHYDE REDUCTASE; AMINE OXIDASE (COPPER-CONTAINING); ANIMALS; AORTA; CELLS, CULTURED; CYTOCHROME P-450 CYP2E1; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FRUCTOSE; FRUCTOSE-BISPHOSPHATE ALDOLASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; GLUCOSE TRANSPORTER TYPE 5; HYPERTENSION; L-IDITOL 2-DEHYDROGENASE; MALE; METABOLIC SYNDROME X; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OBESITY; PYRUVALDEHYDE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; RNA INTERFERENCE; RNA, MESSENGER; TIME FACTORS; TRANSFECTION; UP-REGULATION;

EID: 81055147172     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvr239     Document Type: Article

References (40)

1. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001;414:813-820. (Pubitemid 34000785)
2. Wang X, Desai K, Chang T, Wu L. Vascular methylglyoxal metabolism and the development of hypertension. J Hypertens 2005;23:1565-1573. (Pubitemid 41104829)
3. Wang H, Meng QH, Gordon JR, Khandwala H, Wu L. Proinflammatory and proapoptotic effects of methylglyoxal on neutrophils from patients with type 2 diabetes mellitus. Clin Biochem 2007;40:1232-1239. (Pubitemid 47562425)
4. Wang H, Liu J, Wu L. Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells. Biochem Pharmacol 2009;77:1709-1716.
5. Chang T, Wang R, Wu L. Methylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells. Free Radic Biol Med 2005;38:286-293. (Pubitemid 39656138)
6. Chang T, Untereiner A, Liu J, Wu L. Interaction of methylglyoxal and hydrogen sulfide in rat vascular smooth muscle cells. Antioxid Redox Signal 2010;12:1093-100.
7. Phillips SA, Thornalley PJ. The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal. Eur J Biochem 1993;212: 101-105. (Pubitemid 23064605)
8. Richard JP. Mechanism for the formation of methylglyoxal from triosephosphates. Biochem Soc Trans 1993;21:549-553. (Pubitemid 23167966)
9. Cox TM. Aldolase B and fructose intolerance. FASEB J 1994;8:62-71. (Pubitemid 24047412)
10. Chang T, Wu L. Methylglyoxal, oxidative stress, and hypertension. Can J Physiol Pharmacol 2006;84:1229-1238. (Pubitemid 46707370)
11. Ramasamy R, Yan SF, Schmidt AM. Methylglyoxal comes of AGE. Cell 2006;124: 258-260. (Pubitemid 43121973)
12. Smith JM, Paulson DJ, Solar SM. Na+/K+-ATPase activity in vascular smooth muscle from streptozotocin diabetic rat. Cardiovasc Res 1997;34:137-144.
13. Agren A, Arnqvist HJ. Influence of diabetes on enzyme activities in rat aorta. Diabete Metab 1981;7:19-24. (Pubitemid 11089588)
14. Cameron NE, Cotter MA, Basso M, Hohman TC. Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats. Diabetologia 1997;40:271-281. (Pubitemid 27096550)
15. Wang X, Desai K, Clausen JT, Wu L. Increased methylglyoxal and advanced glycation end products in kidney from spontaneously hypertensive rats. Kidney Int 2004;66: 2315-2321. (Pubitemid 41115295)
16. Wang X, Jia X, Chang T, Desai K, Wu L. Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats. J Hypertens 2008;26:765-772. (Pubitemid 351354925)
17. Jia X, Wu L. Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed rats. Mol Cell Biochem 2007;306:133-139. (Pubitemid 350001825)
18. Wang H, Meng QH, Chang T, Wu L. Fructose-induced peroxynitrite production is mediated by methylglyoxal in vascular smooth muscle cells. Life Sci 2006;79: 2448-2454. (Pubitemid 44750018)
19. Heinz F, LamprechtW, Kirsch J. Enzymes of fructose metabolism in human liver. J Clin Invest 1968;47:1826-1832.
20. Bode C, Bode JC, Ohta W, Martini GA. Adaptative changes of activity of enzymes involved in fructose metabolism in the liver and jejunal mucosa of rats following fructose feeding. Res Exp Med (Berl) 1980;178:55-63. (Pubitemid 11197521)
21. Cross NC, Tolan DR, Cox TM. Catalytic deficiency of human aldolase B in hereditary fructose intolerance caused by a common missense mutation. Cell 1988;53:881-885.
22. Burant CF, Bell GI. Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteins. Biochemistry 1992; 31:10414-10420.
23. Hui H, Huang D, McArthur D, Nissen N, Boros LG, Heaney AP. Direct spectrophotometric determination of serum fructose in pancreatic cancer patients. Pancreas 2009;38:706-712.
24. Chaplen FW, Fahl WE, Cameron DC. Evidence of high levels of methylglyoxal in cultured Chinese hamster ovary cells. Proc Natl Acad Sci USA 1998;95:5533-5538. (Pubitemid 28224129)
25. Dhar A, Desai K, Liu J, Wu L. Methylglyoxal, protein binding and biological samples: are we getting the true measure? J Chromatogr B Analyt Technol Biomed Life Sci 2009; 877:1093-1100.
26. Urbano AM, Gillham H, Groner Y, Brindle KM. Effects of overexpression of the liver subunit of 6-phosphofructo-1-kinase on the metabolism of a cultured mammalian cell line. Biochem J 2000;352:921-927. (Pubitemid 32015050)
27. Umeda M, Otsuka Y, Ii T, Matsuura T, Shibati H, Ota H et al. Determination of D-sorbitol in human erythrocytes by an enzymatic fluorometric method with an improved deproteinization procedure. Ann Clin Biochem 2001;38:701-707. (Pubitemid 33702278)
28. Thornalley PJ. Modification of the glyoxalase system in human red blood cells by glucose in vitro. Biochem J 1988;254:751-755.
29. Chang T, Wang R, Olson DJ, Mousseau DD, Ross AR, Wu L. Modification of Akt1 by methylglyoxal promotes the proliferation of vascular smooth muscle cells. FASEB J 2011;25:1746-1757.
30. Dhar A, Dhar I, Desai KM, Wu L. Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose. Br J Pharmacol 2010;161:1843-1856.
31. Wang X, Chang T, Jiang B, Desai K, Wu L. Attenuation of hypertension development by aminoguanidine in spontaneously hypertensive rats: role of methylglyoxal. Am J Hypertens 2007;20:629-636. (Pubitemid 46777256)
32. Takagawa Y, Berger ME, Hori MT, Tuck ML, Golub MS. Long-term fructose feeding impairs vascular relaxation in rat mesenteric arteries. Am J Hypertens 2001;14: 811-817. (Pubitemid 32682250)
33. Hwang IS, Ho H, Hoffman BB, Reaven GM. Fructose-induced insulin resistance and hypertension in rats. Hypertension 1987;10:512-516. (Pubitemid 18011228)
34. Dhar A, Desai K, Kazachmov M, Yu P, Wu L. Methylglyoxal production in vascular smooth muscle cells from different metabolic precursors. Metabolism 2008;57: 1211-1220.
35. Nandhini AT, Thirunavukkarasu V, Anuradha CV. Taurine modifies insulin signaling enzymes in the fructose-fed insulin resistant rats. Diabetes Metab 2005;31:337-344. (Pubitemid 41391475)
36. Kreisberg RA, Boshell BR, DiPlacido J, Roddam RF. Insulin secretion in obesity. N Engl J Med 1967;276:314-319.
37. Singer P, Godicke W, Voigt S, Hajdu I, Weiss M. Postprandial hyperinsulinemia in patients with mild essential hypertension. Hypertension 1985;7:182-186. (Pubitemid 15093641)
38. Salonen JT, Lakka TA, Lakka HM, Valkonen VP, Everson SA, Kaplan GA. Hyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middle-aged men. Diabetes 1998;47:270-275. (Pubitemid 28079985)
39. Temple RC, Carrington CA, Luzio SD, Owens DR, Schneider AE, Sobey WJ et al. Insulin deficiency in non-insulin-dependent diabetes. Lancet 1989;1:293-295. (Pubitemid 19049403)
40. Kawasaki T, Akanuma H, Yamanouchi T. Increased fructose concentrations in blood and urine in patients with diabetes. Diabetes Care 2002;25:353-357. (Pubitemid 41079635)