Dietary Fructose Activates Insulin Signaling and Inflammation in Adipose Tissue: Modulatory Role of Resveratrol

BioMed Research International

Volumn 2016, Issue , 2016, Pages

  Pektas, Mehmet Bilgehan ^a,b   Koca, Halit Bugra ^a   Sadi, Gokhan ^c   Akar, Fatma ^b  

^a AFYON KOCATEPE UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

^c KARAMANOGLU MEHMETBEY UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; ALANINE AMINOTRANSFERASE; CARBOHYDRATE; FRUCTOSE; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RESVERATROL; TESTOSTERONE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; CARBOHYDRATE DIET; CYTOKINE; NONSTEROID ANTIINFLAMMATORY AGENT; SEX HORMONE; STILBENE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CARBOHYDRATE DIET; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; FOLLOW UP; INFLAMMATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; RAT; WHITE ADIPOSE TISSUE; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; ANIMAL; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; SIGNAL TRANSDUCTION; WISTAR RAT;

ADIPOSE TISSUE, WHITE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYTOKINES; DIETARY CARBOHYDRATES; FEMALE; FRUCTOSE; GONADAL STEROID HORMONES; INFLAMMATION; INSULIN; MALE; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; STILBENES;

EID: 84962815690     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2016/8014252     Document Type: Article

References (42)

1. P. E. Scherer, "Adipose tissue: from lipid storage compartment to endocrine organ, " Diabetes, vol. 55, no. 6, pp. 1537-1545, 2006.
2. F. L. Torres-Leal, M. H. Fonseca-Alaniz, M. M. Rogero, and J. Tirapegui, "The role of inflamed adipose tissue in the insulin resistance, " Cell Biochemistry and Function, vol. 28, no. 8, pp. c623-c631, 2010.
3. J.-P. Bastard, M. Maachi, C. Lagathu et al., "Recent advances in the relationship between obesity, inflammation, and insulin resistance, " European Cytokine Network, vol. 17, no. 1, pp. 4-12, 2006.
4. D. B. Ballak, R. Stienstra, C. J. Tack, C. A. Dinarello, and J. A. van Diepen, "IL-1 family members in the pathogenesis and treatment of metabolic disease: focus on adipose tissue inflammation and insulin resistance, " Cytokine, vol. 75, no. 2, pp. 280-290, 2015.
5. S. Kim, Y. Jin, Y. Choi, and T. Park, "Resveratrol exerts antiobesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice, " Biochemical Pharmacology, vol. 81, no. 11, pp. 1343-1351, 2011.
6. N. Velickovíc, A. Djordjevic, A. Vasiljevíc, B. Bursác, D. V. Milutinovíc, and G. Matíc, "Tissue-specific regulation of inflammation by macrophage migration inhibitory factor and glucocorticoids in fructose-fed Wistar rats, " British Journal of Nutrition, vol. 110, no. 3, pp. 456-465, 2013.
7. C. Babacanoglu, N. Yildirim, G. Sadi, M. B. Pektas, and F. Akar, "Resveratrol prevents high-fructose corn syrup-induced vascular insulin resistance and dysfunction in rats, " Food and Chemical Toxicology, vol. 60, pp. 160-167, 2013.
8. G. Sadi, V. Ergin, G. Yilmaz et al., "High-fructose corn syrupinduced hepatic dysfunction in rats: improving effect of resveratrol, " European Journal of Nutrition, vol. 54, no. 6, pp. 895-904, 2015.
9. M. P. Czech, M. Tencerova, D. J. Pedersen, and M. Aouadi, "Insulin signalling mechanisms for triacylglycerol storage, " Diabetologia, vol. 56, no. 5, pp. 949-964, 2013.
10. T. J. Horton, E. C. Gayles, P. A. Prach, T. A. Koppenhafer, and M. J. Pagliassotti, "Female rats do not develop sucroseinduced insulin resistance, " American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol. 272, no. 5, pp. R1571-R1576, 1997.
11. Y. Gómez-Pérez, E. Amengual-Cladera, A. Català-Niell et al., "Gender dimorphism in high-fat-diet-induced insulin resistance in skeletal muscle of aged rats, " Cellular Physiology and Biochemistry, vol. 22, no. 5-6, pp. 539-548, 2008.
12. R. E. Stubbins, V. B. Holcomb, J. Hong, and N. P. Núñez, "Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance, " European Journal of Nutrition, vol. 51, no. 7, pp. 861-870, 2012.
13. M. B. Pektas, G. Sadi, and F. Akar, "Long-TermDietary Fructose Causes Gender-Different Metabolic and Vascular Dysfunction in Rats: Modulatory Effects of Resveratrol, " Cellular Physiology and Biochemistry, vol. 37, no. 4, pp. 1407-1420, 2015.
14. K. L. Stanhope, J. M. Schwarz, N. L. Keim et al., "Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans, "The Journal of Clinical Investigation, vol. 119, no. 5, pp. 1322-1334, 2009.
15. T. Yoshizaki, J. C. Milne, T. Imamura et al., "SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes, " Molecular and Cellular Biology, vol. 29, no. 5, pp. 1363-1374, 2009.
16. R. Zoncu, A. Efeyan, and D. M. Sabatini, "MTOR: from growth signal integration to cancer, diabetes and ageing, " Nature Reviews Molecular Cell Biology, vol. 12, no. 1, pp. 21-35, 2011.
17. R. Muniyappa and J. R. Sowers, "Role of insulin resistance in endothelial dysfunction, " Reviews in Endocrine and Metabolic Disorders, vol. 14, no. 1, pp. 5-12, 2013.
18. M. S. Brown and J. L. Goldstein, "Selective versus total insulin resistance: A pathogenic paradox, " Cell Metabolism, vol. 7, no. 2, pp. 95-96, 2008.
19. M. J. Dekker, Q. Su, C. Baker, A. C. Rutledge, and K. Adeli, "Fructose: A highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome, " American Journal of Physiology-Endocrinology and Metabolism, vol. 299, no. 5, pp. E685-E694, 2010.
20. H. Shi, B. Cave, K. Inouye, C. Bjørbæk, and J. S. Flier, "Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance, " Diabetes, vol. 55, no. 3, pp. 699-707, 2006.
21. F.-Y. Gong, S.-J. Zhang, J.-Y. Deng et al., "Zinc-2-glycoprotein is involved in regulation of body weight through inhibition of lipogenic enzymes in adipose tissue, " International Journal of Obesity, vol. 33, no. 9, pp. 1023-1030, 2009.
22. Z. Khitan, M. Harsh, K. Sodhi, J. I. Shapiro, and N. G. Abraham, "HO-1 Upregulation attenuates adipocyte dysfunction, obesity, and isoprostane levels in mice fed high fructose diets, " Journal of Nutrition and Metabolism, vol. 2014, Article ID980547, 13pages, 2014.
23. S. T. Nadler, J. P. Stoehr, K. L. Schueler, G. Tanimoto, B. S. Yandell, and A. D. Attie, "The expression of adipogenic genes is decreased in obesity and diabetesmellitus, " Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 21, pp. 11371-11376, 2000.
24. H. Lan, M. E. Rabaglia, J. P. Stoehr et al., "Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility, " Diabetes, vol. 52, no. 3, pp. 688-700, 2003.
25. S. F. Previs, D. J. Withers, J.-M. Ren, M. F. White, and G. I. Shulman, "Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo, " The Journal of Biological Chemistry, vol. 275, no. 50, pp. 38990-38994, 2000.
26. C. X. Zhao, X. Xu, Y. Cui et al., "Increased endothelial nitricoxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats, " Journal of Pharmacology and Experimental Therapeutics, vol. 328, no. 2, pp. 610-620, 2009.
27. J. T. Haas, J. Miao, D. Chanda et al., "Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression, " CellMetabolism, vol. 15, no. 6, pp. 873-884, 2012.
28. A. Alzamendi, A. Giovambattista, A. Raschia et al., "Fructoserich diet-induced abdominal adipose tissue endocrine dysfunction in normal male rats, " Endocrine, vol. 35, no. 2, pp. 227-232, 2009.
29. A. Alzamendi, A. Giovambattista, M. E. Garciá, O. R. Rebolledo, J. J. Gagliardino, and E. Spinedi, "Effect of pioglitazone on the fructose-induced abdominal adipose tissue dysfunction, " PPAR Research, vol. 2012, Article ID 259093, 9 pages, 2012.
30. X. Ma, L. Lin, J. Yue et al., "Ghrelin receptor regulates HFCSinduced adipose inflammation and insulin resistance, " Nutrition & Diabetes, vol. 3, no. 12, p. e99, 2013.
31. V. Rotter, I. Nagaev, and U. Smith, "Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-, overexpressed in human fat cells from insulin-resistant subjects, " The Journal of Biological Chemistry, vol. 278, no. 46, pp. 45777-45784, 2003.
32. J. Jager, T. Grémeaux, M. Cormont, Y. Le Marchand-Brustel, and J.-F. Tanti, "Interleukin-1-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression, " Endocrinology, vol. 148, no. 1, pp. 241-251, 2007.
33. K. S. Schneider and J. Y. Chan, "Emerging role of Nrf2 in adipocytes and adipose biology, " Advances in Nutrition, vol. 4, no. 1, pp. 62-66, 2013.
34. R. T. Enos, K. T. Velázquez, J. L. McClellan, T. L. Cranford, M. D. Walla, and E. A. Murphy, "Reducing the dietary omega-6: omega-3 utilizing a-linolenic acid; Not a sufficient therapy for attenuating high-fat-diet-induced obesity development nor related detrimental metabolic and adipose tissue inflammatory outcomes, " PLoS ONE, vol. 9, no. 4, Article ID e94897, 2014.
35. L. Serrano-Marco, M. R. Chacón, E. Maymó-Masip et al., "TNF-inhibits PPAR/ activity and SIRT1 expression through NF-B in human adipocytes, " Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, vol. 1821, no. 9, pp. 1177-1185, 2012.
36. D. C. Magliano, A. Penna-de-Carvalho, M. Vazquez-Carrera, C. A. Mandarim-de-Lacerda, and M. B. Aguila, "Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system, " Endocrine, vol. 50, no. 2, pp. 355-367, 2015.
37. E. Barroso, R. Rodríguez-Rodríguez, M. R. Chacón et al., "PPAR/ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation, " Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, vol. 1852, no. 5, pp. 1049-1058, 2015.
38. H. Vasudevan, H. Xiang, and J. H. McNeill, "Differential regulation of insulin resistance and hypertension by sex hormones in fructose-fed male rats, " American Journal of Physiology-Heart and Circulatory Physiology, vol. 289, no. 4, pp. H1335-H1342, 2005.
39. H. Vasudevan, P. R. Nagareddy, and J. H. McNeill, "Gonadectomy prevents endothelial dysfunction in fructose-fed male rats, a factor contributing to the development of hypertension, " The American Journal of Physiology-Heart and Circulatory Physiology, vol. 291, no. 6, pp. H3058-H3064, 2006.
40. W. Kang, H. J. Hong, J. Guan et al., "Resveratrol improves insulin signaling in a tissue-specific manner under insulinresistant conditions only: in vitro and in vivo experiments in rodents, " Metabolism, vol. 61, no. 3, pp. 424-433, 2012.
41. Y. Jimenez-Gomez, J. A. Mattison, K. J. Pearson et al., "Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on highfat, high-sugar diet, " CellMetabolism, vol. 18, no. 4, pp. 533-545, 2013.
42. L. Rivera, R. Morón, A. Zarzuelo, and M. Galisteo, "Longtermresveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats, " Biochemical Pharmacology, vol. 77, no. 6, pp. 1053-1063, 2009.