Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling

American Journal of Physiology - Endocrinology and Metabolism

Volumn 283, Issue 2 46-2, 2002, Pages

  Choi, Cheol S ^a   Kim, Young Bum ^b   Lee, Felix N ^c   Zabolotny, Janice M ^a   Kahn, Barbara B ^a   Youn, Jang H ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Euglycemic clamp; Glucose transport; Rat GLUT4

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; HYPERINSULINEMIA; INSULIN RELEASE; INSULIN RESISTANCE; LACTATE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TISSUE HOMOGENATE;

EID: 0036320908     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00557.2001     Document Type: Article

References (37)

1. Muscle fiber type composition of the rat hindlimb
2. Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans
3. Insulin resistance in skeletal muscles in patients with NIDDM
4. Quantitation of measurement error with Optimal Segments: Basis for adaptive time course smoothing
5. Glucose-induced glycogenesis in the liver involves the glucose-6-phosphate-dependent dephosphorylation of glycogen synthase
6. Dichloroacetate inhibits glycolysis and augments insulin-stimulated glycogen synthesis in rat muscle
7. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes
8. Skeletal muscle is a major site of lactate uptake and release during hyperinsulinemia
9. Hepatic and peripheral insulin resistance: A common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus
10. Cyclic AMP suppresses the inhibition of glycolysis by alternative oxidizable substrates in the heart
11. Role of fructose 2,6-bisphosphate in the control of glycolysis. Stimulation of glycogen synthesis by lactate in the isolated working rat heart
12. Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice
13. Impaired insulin-stimulated muscle glycogen synthase activation in vivo in man is related to low fasting glycogen synthase phosphatase activity
14. Glucose transport and NIDDM
15. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
16. Effect of diffusion distance on measurement of rat skeletal muscle glucose transport in vitro
17. A comparison of the relative effects of obesity and non-insulin-dependent diabetes mellitus on in vivo insulin-stimulated glucose utilization
18. Acute effect of growth hormone to induce peripheral insulin resistance is independent of FFA and insulin levels in rats
19. Metabolic impairment precedes insulin resistance in skeletal muscle during high fat feeding in rats
20. Prolonged suppression of glucose metabolism causes insulin resistance in rat skeletal muscle
21. Normal insulin-dependent activation of Akt/protein kinase B 13, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
22. Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle
23. Receptor and postreceptor defects contribute to the insulin resistance in non-insulin-dependent diabetes mellitus
24. Hyperlactatemia reduces muscle glucose uptake and GLUT-4 mRNA while increasing (E1α)PDH gene expression in rat
25. Role of the lactate transporter (MCT1) in skeletal muscles
26. Epitrochlearis muscle. I. Mechanical performance, energetics, and fiber composition
27. Effect of lactate and palmitate on substrate utilization of isolated rat soleus
28. Deficiency of phosphofructo-1-kinase/muscle subtype in humans impairs insulin secretion and causes insulin resistance
29. Insulin resistance and impaired insulin secretion due to phosphofructo-1-kinase-deficiency in humans
30. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus
31. Impaired activation of glycogen synthase in people at increased risk for developing NIDDM
32. Inhibition of endogenous lactate turnover with lactate infusion in humans
33. Measurement of size and turnover rate of body glucose pool by the isotope dilution method
34. Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus
35. Glucose-fatty acid cycle operates in humans at the levels of both whole body and skeletal muscle during low and high physiological plasma insulin concentrations
36. Lactate infusion in anesthetized rats produces insulin resistance in heart and skeletal muscles
37. The role of glucose 6-phosphate in the control of glycogen synthase