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Volumn 42, Issue 1, 2017, Pages 193-215

Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders

Author keywords

[No Author keywords available]

Indexed keywords

CYSTINE; GAMMA INTERFERON; GLUTAMIC ACID; INTERLEUKIN 1BETA; INTERLEUKIN 6; IONOTROPIC RECEPTOR; KYN PROTEIN; METABOTROPIC RECEPTOR; PROTEIN; PURINERGIC P2X7 RECEPTOR; QUINOLINIC ACID; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

EID: 84992418546     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2016.199     Document Type: Article
Times cited : (357)

References (286)
  • 1
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at theblood-brain barrier
    • Abbott NJ, Ronnback L, Hansson E (2006). Astrocyte-endothelial interactions at theblood-brain barrier. Nat Rev Neurosci 7: 41-53.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 2
    • 84949292745 scopus 로고    scopus 로고
    • Synaptic efficacy as a function of ionotropic receptor distribution: Acomputational study
    • Allam SL, Bouteiller JM, Hu EY, Ambert N, Greget R, Bischoff S, et al. (2015).Synaptic efficacy as a function of ionotropic receptor distribution: acomputational study. PLoS One 10: e0140333.
    • (2015) PLoS One , vol.10 , pp. e0140333
    • Allam, S.L.1    Bouteiller, J.M.2    Hu, E.Y.3    Ambert, N.4    Greget, R.5    Bischoff, S.6
  • 3
    • 84865959223 scopus 로고    scopus 로고
    • Acomputational model to investigate astrocytic glutamate uptake influence onsynaptic transmission and neuronal spiking
    • Allam SL, Ghaderi VS, Bouteiller JM, Legendre A, Ambert N, Greget R, et al. (2012). Acomputational model to investigate astrocytic glutamate uptake influence onsynaptic transmission and neuronal spiking. Front Comput Neurosci 6: 70.
    • (2012) Front Comput Neurosci , vol.6 , pp. 70
    • Allam, S.L.1    Ghaderi, V.S.2    Bouteiller, J.M.3    Legendre, A.4    Ambert, N.5    Greget, R.6
  • 4
    • 84910597319 scopus 로고    scopus 로고
    • Nervous and immune systems signals and connections: Cytokinesin hippocampus physiology and pathology
    • Arisi GM (2014). Nervous and immune systems signals and connections: cytokinesin hippocampus physiology and pathology. Epilepsy Behav 38: 43-47.
    • (2014) Epilepsy Behav , vol.38 , pp. 43-47
    • Arisi, G.M.1
  • 5
    • 0030932152 scopus 로고    scopus 로고
    • Excitatory amino acidtransporter 5, a retinal glutamate transporter coupled to a chloride conductance
    • Arriza JL, Eliasof S, Kavanaugh MP, Amara SG (1997). Excitatory amino acidtransporter 5, a retinal glutamate transporter coupled to a chloride conductance.Proc Natl Acad Sci USA 94: 4155-4160.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4155-4160
    • Arriza, J.L.1    Eliasof, S.2    Kavanaugh, M.P.3    Amara, S.G.4
  • 6
    • 0037743546 scopus 로고    scopus 로고
    • Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse
    • Baker DA, McFarland K, Lake RW, Shen H, Tang XC, Toda S, et al. (2003).Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. NatNeurosci 6: 743-749.
    • (2003) NatNeurosci , vol.6 , pp. 743-749
    • Baker, D.A.1    McFarland, K.2    Lake, R.W.3    Shen, H.4    Tang, X.C.5    Toda, S.6
  • 7
    • 77951880669 scopus 로고    scopus 로고
    • Glial pathology in an animal model of depression: Reversal of stressinducedcellular, metabolic and behavioral deficits by the glutamate-modulatingdrug riluzole
    • Banasr M, Chowdhury GM, Terwilliger R, Newton SS, Duman RS, Behar KL, et al.(2010). Glial pathology in an animal model of depression: reversal of stressinducedcellular, metabolic and behavioral deficits by the glutamate-modulatingdrug riluzole. Mol Psychiatry 15: 501-511.
    • (2010) Mol Psychiatry , vol.15 , pp. 501-511
    • Banasr, M.1    Chowdhury, G.M.2    Terwilliger, R.3    Newton, S.S.4    Duman, R.S.5    Behar, K.L.6
  • 8
    • 54149093900 scopus 로고    scopus 로고
    • Glial loss in the prefrontal cortex is sufficient to inducedepressive-like behaviors
    • Banasr M, Duman RS (2008). Glial loss in the prefrontal cortex is sufficient to inducedepressive-like behaviors. Biol Psychiatry 64: 863-870.
    • (2008) Biol Psychiatry , vol.64 , pp. 863-870
    • Banasr, M.1    Duman, R.S.2
  • 9
    • 34548046778 scopus 로고    scopus 로고
    • Chronicunpredictable stress decreases cell proliferation in the cerebral cortex of theadult rat
    • Banasr M, Valentine GW, Li XY, Gourley SL, Taylor JR, Duman RS (2007). Chronicunpredictable stress decreases cell proliferation in the cerebral cortex of theadult rat. Biol Psychiatry 62: 496-504.
    • (2007) Biol Psychiatry , vol.62 , pp. 496-504
    • Banasr, M.1    Valentine, G.W.2    Li, X.Y.3    Gourley, S.L.4    Taylor, J.R.5    Duman, R.S.6
  • 10
    • 67349178848 scopus 로고    scopus 로고
    • Subcortical oligodendrocyte-and astrocyteassociatedgene expression in subjects with schizophrenia, major depression andbipolar disorder
    • Barley K, Dracheva S, Byne W (2009). Subcortical oligodendrocyte-and astrocyteassociatedgene expression in subjects with schizophrenia, major depression andbipolar disorder. Schizophr Res 112: 54-64.
    • (2009) Schizophr Res , vol.112 , pp. 54-64
    • Barley, K.1    Dracheva, S.2    Byne, W.3
  • 11
    • 55049084760 scopus 로고    scopus 로고
    • The mystery and magic of glia: A perspective on their roles inhealth and disease
    • Barres BA (2008). The mystery and magic of glia: a perspective on their roles inhealth and disease. Neuron 60: 430-440.
    • (2008) Neuron , vol.60 , pp. 430-440
    • Barres, B.A.1
  • 12
    • 0346770038 scopus 로고    scopus 로고
    • Age-related myelin breakdown: A developmental model ofcognitive decline and Alzheimer's disease
    • Bartzokis G (2004). Age-related myelin breakdown: a developmental model ofcognitive decline and Alzheimer's disease. Neurobiol Aging 25: 5-18.
    • (2004) Neurobiol Aging , vol.25 , pp. 5-18
    • Bartzokis, G.1
  • 13
    • 84927649811 scopus 로고    scopus 로고
    • SynapticNMDA receptor activity is coupled to the transcriptional control of theglutathione system
    • Baxter PS, Bell KF, Hasel P, Kaindl AM, Fricker M, Thomson D, et al. (2015). SynapticNMDA receptor activity is coupled to the transcriptional control of theglutathione system. Nat Commun 6: 6761.
    • (2015) Nat Commun , vol.6 , pp. 6761
    • Baxter, P.S.1    Bell, K.F.2    Hasel, P.3    Kaindl, A.M.4    Fricker, M.5    Thomson, D.6
  • 16
    • 0031472475 scopus 로고    scopus 로고
    • Synaptic activation of glutamate transporters inhippocampal astrocytes
    • Bergles DE, Jahr CE (1997). Synaptic activation of glutamate transporters inhippocampal astrocytes. Neuron 19: 1297-1308.
    • (1997) Neuron , vol.19 , pp. 1297-1308
    • Bergles, D.E.1    Jahr, C.E.2
  • 17
    • 79957492129 scopus 로고    scopus 로고
    • Altered expression of glutamate signaling, growth factor, and glia genes inthe locus coeruleus of patients with major depression
    • Bernard R, Kerman IA, Thompson RC, Jones EG, Bunney WE, Barchas JD, et al.(2011). Altered expression of glutamate signaling, growth factor, and glia genes inthe locus coeruleus of patients with major depression. Mol Psychiatry 16:634-646.
    • (2011) Mol Psychiatry , vol.16 , pp. 634-646
    • Bernard, R.1    Kerman, I.A.2    Thompson, R.C.3    Jones, E.G.4    Bunney, W.E.5    Barchas, J.D.6
  • 18
    • 0034960228 scopus 로고    scopus 로고
    • CXCR4-activated astrocyte glutamate release via TNFalpha: Amplification bymicroglia triggers neurotoxicity
    • Bezzi P, Domercq M, Brambilla L, Galli R, Schols D, De Clercq E, et al. (2001).CXCR4-activated astrocyte glutamate release via TNFalpha: amplification bymicroglia triggers neurotoxicity. Nat Neurosci 4: 702-710.
    • (2001) Nat Neurosci , vol.4 , pp. 702-710
    • Bezzi, P.1    Domercq, M.2    Brambilla, L.3    Galli, R.4    Schols, D.5    De Clercq, E.6
  • 19
    • 84949528773 scopus 로고    scopus 로고
    • Geneticand stress-induced loss of NG2 glia triggers emergence of depressive-likebehaviors through reduced secretion of FGF2
    • Birey F, Kloc M, Chavali M, Hussein I, Wilson M, Christoffel DJ, et al. (2015). Geneticand stress-induced loss of NG2 glia triggers emergence of depressive-likebehaviors through reduced secretion of FGF2. Neuron 88: 941-956.
    • (2015) Neuron , vol.88 , pp. 941-956
    • Birey, F.1    Kloc, M.2    Chavali, M.3    Hussein, I.4    Wilson, M.5    Christoffel, D.J.6
  • 20
    • 0036753235 scopus 로고    scopus 로고
    • Low glial numbers in theamygdala in major depressive disorder
    • Bowley MP, Drevets WC, Ongur D, Price JL (2002). Low glial numbers in theamygdala in major depressive disorder. Biol Psychiatry 52: 404-412.
    • (2002) Biol Psychiatry , vol.52 , pp. 404-412
    • Bowley, M.P.1    Drevets, W.C.2    Ongur, D.3    Price, J.L.4
  • 21
    • 0027749707 scopus 로고
    • Multinuclear NMRstudies on the energy metabolism of glial and neuronal cells
    • Brand A, Richter-Landsberg C, Leibfritz D (1993). Multinuclear NMRstudies on the energy metabolism of glial and neuronal cells. Dev Neurosci 15:289-298.
    • (1993) Dev Neurosci , vol.15 , pp. 289-298
    • Brand, A.1    Richter-Landsberg, C.2    Leibfritz, D.3
  • 22
    • 64449089015 scopus 로고    scopus 로고
    • Juvenileseparation stress induces rapid region-and layer-specific changes in S100ssandglial fibrillary acidic protein-immunoreactivity in astrocytes of the rodent medialprefrontal cortex
    • Braun K, Antemano R, Helmeke C, Buchner M, Poeggel G (2009). Juvenileseparation stress induces rapid region-and layer-specific changes in S100ssandglial fibrillary acidic protein-immunoreactivity in astrocytes of the rodent medialprefrontal cortex. Neuroscience 160: 629-638.
    • (2009) Neuroscience , vol.160 , pp. 629-638
    • Braun, K.1    Antemano, R.2    Helmeke, C.3    Buchner, M.4    Poeggel, G.5
  • 23
    • 84954068135 scopus 로고    scopus 로고
    • Neuroinflammation and depression: Microgliaactivation, extracellular microvesicles and microRNA dysregulation
    • Brites D, Fernandes A (2015). Neuroinflammation and depression: microgliaactivation, extracellular microvesicles and microRNA dysregulation. Front CellNeurosci 9: 476.
    • (2015) Front CellNeurosci , vol.9 , pp. 476
    • Brites, D.1    Fernandes, A.2
  • 24
    • 84891371475 scopus 로고    scopus 로고
    • Riluzole partially rescues age-associated, but not LPS-induced, loss of glutamatetransporters and spatial memory
    • Brothers HM, Bardou I, Hopp SC, Kaercher RM, Corona AW, Fenn AM, et al. (2013).Riluzole partially rescues age-associated, but not LPS-induced, loss of glutamatetransporters and spatial memory. J Neuroimmune Pharmacol 8: 1098-1105.
    • (2013) J Neuroimmune Pharmacol , vol.8 , pp. 1098-1105
    • Brothers, H.M.1    Bardou, I.2    Hopp, S.C.3    Kaercher, R.M.4    Corona, A.W.5    Fenn, A.M.6
  • 26
    • 0036139877 scopus 로고    scopus 로고
    • Protoplasmic astrocytesin CA1 stratum radiatum occupy separate anatomical domains
    • Bushong EA, Martone ME, Jones YZ, Ellisman MH (2002). Protoplasmic astrocytesin CA1 stratum radiatum occupy separate anatomical domains. J Neurosci 22:183-192.
    • (2002) J Neurosci , vol.22 , pp. 183-192
    • Bushong, E.A.1    Martone, M.E.2    Jones, Y.Z.3    Ellisman, M.H.4
  • 27
    • 28444491492 scopus 로고    scopus 로고
    • Role of glutamate transporters in the clearance andrelease of glutamate during ischemia and its relation to neuronal death
    • Camacho A, Massieu L (2006). Role of glutamate transporters in the clearance andrelease of glutamate during ischemia and its relation to neuronal death. Arch MedRes 37: 11-18.
    • (2006) Arch MedRes , vol.37 , pp. 11-18
    • Camacho, A.1    Massieu, L.2
  • 28
    • 0142250797 scopus 로고    scopus 로고
    • Interferon-alpha-induced changes in tryptophan metabolism. Relationshipto depression and paroxetine treatment
    • Capuron L, Neurauter G, Musselman DL, Lawson DH, Nemeroff CB, Fuchs D, et al.(2003). Interferon-alpha-induced changes in tryptophan metabolism. Relationshipto depression and paroxetine treatment. Biol Psychiatry 54: 906-914.
    • (2003) Biol Psychiatry , vol.54 , pp. 906-914
    • Capuron, L.1    Neurauter, G.2    Musselman, D.L.3    Lawson, D.H.4    Nemeroff, C.B.5    Fuchs, D.6
  • 29
    • 84879886446 scopus 로고    scopus 로고
    • Brain aging inhumans, chimpanzees (Pan troglodytes), and rhesus macaques (Macacamulatta): Magnetic resonance imaging studies of macro-and microstructural changes
    • Chen X, Errangi B, Li L, Glasser MF, Westlye LT, Fjell AM, et al. (2013). Brain aging inhumans, chimpanzees (Pan troglodytes), and rhesus macaques (Macacamulatta): magnetic resonance imaging studies of macro-and microstructuralchanges. Neurobiol Aging 34: 2248-2260.
    • (2013) Neurobiol Aging , vol.34 , pp. 2248-2260
    • Chen, X.1    Errangi, B.2    Li, L.3    Glasser, M.F.4    Westlye, L.T.5    Fjell, A.M.6
  • 30
    • 0028178798 scopus 로고
    • Tumor necrosis factors protect neuronsagainst metabolic-excitotoxic insults and promote maintenance of calciumhomeostasis
    • Cheng B, Christakos S, Mattson MP (1994). Tumor necrosis factors protect neuronsagainst metabolic-excitotoxic insults and promote maintenance of calciumhomeostasis. Neuron 12: 139-153.
    • (1994) Neuron , vol.12 , pp. 139-153
    • Cheng, B.1    Christakos, S.2    Mattson, M.P.3
  • 31
    • 0034750095 scopus 로고    scopus 로고
    • Synthesis and release ofneurotoxic kynurenine metabolites by human monocyte-derived macrophages
    • Chiarugi A, Calvani M, Meli E, Traggiai E, Moroni F (2001a). Synthesis and release ofneurotoxic kynurenine metabolites by human monocyte-derived macrophages. JNeuroimmunol 120: 190-198.
    • (2001) J Neuroimmunol , vol.120 , pp. 190-198
    • Chiarugi, A.1    Calvani, M.2    Meli, E.3    Traggiai, E.4    Moroni, F.5
  • 32
    • 0035010218 scopus 로고    scopus 로고
    • Similarities and differences in the neuronaldeath processes activated by 3OH-kynurenine and quinolinic acid
    • Chiarugi A, Meli E, Moroni F (2001b). Similarities and differences in the neuronaldeath processes activated by 3OH-kynurenine and quinolinic acid. J Neurochem77: 1310-1318.
    • (2001) J Neurochem , vol.77 , pp. 1310-1318
    • Chiarugi, A.1    Meli, E.2    Moroni, F.3
  • 33
    • 84887002896 scopus 로고    scopus 로고
    • The dynamic synapse
    • Choquet D, Triller A (2013). The dynamic synapse. Neuron 80: 691-703.
    • (2013) Neuron , vol.80 , pp. 691-703
    • Choquet, D.1    Triller, A.2
  • 35
    • 0031017893 scopus 로고    scopus 로고
    • Inhibition of the high-affinity brain glutamate transporterGLAST-1 via direct phosphorylation
    • Conradt M, Stoffel W (1997). Inhibition of the high-affinity brain glutamate transporterGLAST-1 via direct phosphorylation. J Neurochem 68: 1244-1251.
    • (1997) J Neurochem , vol.68 , pp. 1244-1251
    • Conradt, M.1    Stoffel, W.2
  • 36
    • 0036501099 scopus 로고    scopus 로고
    • Thedensity and spatial distribution of GABAergic neurons, labelled using calciumbinding proteins, in the anterior cingulate cortex in major depressive disorder,bipolar disorder, and schizophrenia
    • Cotter D, Landau S, Beasley C, Stevenson R, Chana G, MacMillan L, et al. (2002). Thedensity and spatial distribution of GABAergic neurons, labelled using calciumbinding proteins, in the anterior cingulate cortex in major depressive disorder,bipolar disorder, and schizophrenia. Biol Psychiatry 51: 377-386.
    • (2002) Biol Psychiatry , vol.51 , pp. 377-386
    • Cotter, D.1    Landau, S.2    Beasley, C.3    Stevenson, R.4    Chana, G.5    MacMillan, L.6
  • 37
    • 0035878167 scopus 로고    scopus 로고
    • Glial cell abnormalities in major psychiatricdisorders: The evidence and implications
    • Cotter DR, Pariante CM, Everall IP (2001). Glial cell abnormalities in major psychiatricdisorders: the evidence and implications. Brain Res Bull 55: 585-595.
    • (2001) Brain Res Bull , vol.55 , pp. 585-595
    • Cotter, D.R.1    Pariante, C.M.2    Everall, I.P.3
  • 38
    • 33746279595 scopus 로고    scopus 로고
    • Astroglial plasticity inthe hippocampus is affected by chronic psychosocial stress and concomitantfluoxetine treatment
    • Czeh B, Simon M, Schmelting B, Hiemke C, Fuchs E (2006). Astroglial plasticity inthe hippocampus is affected by chronic psychosocial stress and concomitantfluoxetine treatment. Neuropsychopharmacology 31: 1616-1626.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 1616-1626
    • Czeh, B.1    Simon, M.2    Schmelting, B.3    Hiemke, C.4    Fuchs, E.5
  • 39
    • 60849135712 scopus 로고    scopus 로고
    • Cerebral microglia recruit monocytes into thebrain in response to tumor necrosis factoralpha signaling during peripheral organinflammation
    • D'Mello C, Le T, Swain MG (2009). Cerebral microglia recruit monocytes into thebrain in response to tumor necrosis factoralpha signaling during peripheral organinflammation. J Neurosci 29: 2089-2102.
    • (2009) J Neurosci , vol.29 , pp. 2089-2102
    • D'Mello, C.1    Le Swain T, M.G.2
  • 40
    • 0035001341 scopus 로고    scopus 로고
    • Glutamate uptake
    • Danbolt NC (2001). Glutamate uptake. Prog Neurobiol 65: 1-105.
    • (2001) Prog Neurobiol , vol.65 , pp. 1-105
    • Danbolt, N.C.1
  • 41
  • 43
    • 84925702647 scopus 로고    scopus 로고
    • Is there a role for glutamate-mediated excitotoxicity ininflammation-induced depression?
    • Dantzer R, Walker AK (2014). Is there a role for glutamate-mediated excitotoxicity ininflammation-induced depression? J Neural Transm 121: 925-932.
    • (2014) J Neural Transm , vol.121 , pp. 925-932
    • Dantzer, R.1    Walker, A.K.2
  • 44
    • 84971475341 scopus 로고    scopus 로고
    • Modulation of synaptic plasticity by glutamatergicgliotransmission: A modeling study
    • De Pitta M, Brunel N (2016). Modulation of synaptic plasticity by glutamatergicgliotransmission: a modeling study. Neural Plast 2016: 7607924.
    • (2016) Neural Plast , vol.2016 , pp. 7607924
    • De Pitta, M.1    Brunel, N.2
  • 46
    • 84896702066 scopus 로고    scopus 로고
    • Activation and regulation ofcellular inflammasomes: Gaps in our knowledge for central nervous system injury
    • de Rivero Vaccari JP, Dietrich WD, Keane RW (2014). Activation and regulation ofcellular inflammasomes: gaps in our knowledge for central nervous system injury.J Cereb Blood Flow Metab 34: 369-375.
    • (2014) J Cereb Blood Flow Metab , vol.34 , pp. 369-375
    • De Rivero Vaccari, J.P.1    Dietrich, W.D.2    Keane, R.W.3
  • 47
    • 84952639919 scopus 로고    scopus 로고
    • Therapeuticstargeting the inflammasome after central nervous system injury
    • de Rivero Vaccari JP, Dietrich WD, Keane RW (2016b). Therapeuticstargeting the inflammasome after central nervous system injury. Transl Res 167:35-45.
    • (2016) Transl Res , vol.167 , pp. 35-45
    • De Rivero Vaccari, J.P.1    Dietrich, W.D.2    Keane, R.W.3
  • 48
    • 54249124166 scopus 로고    scopus 로고
    • Aging microglial cell priming, and the discordantcentral inflammatory response to signals from the peripheral immune system
    • Dilger RN, Johnson RW (2008). Aging, microglial cell priming, and the discordantcentral inflammatory response to signals from the peripheral immune system.J Leukoc Biol 84: 932-939.
    • (2008) J Leukoc Biol , vol.84 , pp. 932-939
    • Dilger, R.N.1    Johnson, R.W.2
  • 49
    • 84930872206 scopus 로고    scopus 로고
    • NG2-glia and their functions in the central nervous system
    • Dimou L, Gallo V (2015). NG2-glia and their functions in the central nervous system.Glia 63: 1429-1451.
    • (2015) Glia , vol.63 , pp. 1429-1451
    • Dimou, L.1    Gallo, V.2
  • 50
    • 34248174912 scopus 로고    scopus 로고
    • System xc-and glutamate transporter inhibition mediates microglialtoxicity to oligodendrocytes
    • Domercq M, Sanchez-Gomez MV, Sherwin C, Etxebarria E, Fern R, Matute C(2007). System xc-and glutamate transporter inhibition mediates microglialtoxicity to oligodendrocytes. J Immunol 178: 6549-6556.
    • (2007) J Immunol , vol.178 , pp. 6549-6556
    • Domercq, M.1    Sanchez-Gomez, M.V.2    Sherwin, C.3    Etxebarria, E.4    Fern, R.5    Matute, C.6
  • 53
    • 84898867072 scopus 로고    scopus 로고
    • Pathophysiology of depression and innovative treatments:remodeling glutamatergic synaptic connections
    • Duman RS (2014). Pathophysiology of depression and innovative treatments:remodeling glutamatergic synaptic connections. Dialogues Clin Neurosci 16:11-27.
    • (2014) Dialogues Clin Neurosci , vol.16 , pp. 11-27
    • Duman, R.S.1
  • 54
    • 84978745497 scopus 로고    scopus 로고
    • Synaptic plasticity anddepression: New insights from stress and rapid-acting antidepressants
    • Duman RS, Aghajanian GK, Sanacora G, Krystal JH (2016). Synaptic plasticity anddepression: new insights from stress and rapid-acting antidepressants. Nat Med22: 238-249.
    • (2016) Nat Med , vol.22 , pp. 238-249
    • Duman, R.S.1    Aghajanian, G.K.2    Sanacora, G.3    Krystal, J.H.4
  • 55
    • 84855297758 scopus 로고    scopus 로고
    • Signaling pathways underlying the pathophysiology andtreatment of depression: Novel mechanisms for rapid-acting agents
    • Duman RS, Voleti B (2012). Signaling pathways underlying the pathophysiology andtreatment of depression: novel mechanisms for rapid-acting agents. TrendsNeurosci 35: 47-56.
    • (2012) TrendsNeurosci , vol.35 , pp. 47-56
    • Duman, R.S.1    Voleti, B.2
  • 56
    • 84957606739 scopus 로고    scopus 로고
    • Targeting glia with N-acetylcysteine modulates brain glutamate andbehaviors relevant to neurodevelopmental disorders in C57BL/6J mice
    • Durieux AM, Fernandes C, Murphy D, Labouesse MA, Giovanoli S, Meyer U, et al.(2015). Targeting glia with N-acetylcysteine modulates brain glutamate andbehaviors relevant to neurodevelopmental disorders in C57BL/6J mice. FrontBehav Neurosci 9: 343.
    • (2015) FrontBehav Neurosci , vol.9 , pp. 343
    • Durieux, A.M.1    Fernandes, C.2    Murphy, D.3    Labouesse, M.A.4    Giovanoli, S.5    Meyer, U.6
  • 57
    • 84860443755 scopus 로고    scopus 로고
    • A putative functional role for oligodendrocytes in moodregulation
    • Edgar N, Sibille E (2012). A putative functional role for oligodendrocytes in moodregulation. Transl Psychiatry 2: e109
    • (2012) Transl Psychiatry , vol.2 , pp. e109
    • Edgar, N.1    Sibille, E.2
  • 59
    • 84983130412 scopus 로고    scopus 로고
    • Understanding the role of T cells inCNS homeostasis
    • Ellwardt E, Walsh JT, Kipnis J, Zipp F (2016). Understanding the role of T cells inCNS homeostasis. Trends Immunol 37: 154-165.
    • (2016) Trends Immunol , vol.37 , pp. 154-165
    • Ellwardt, E.1    Walsh, J.T.2    Kipnis, J.3    Zipp, F.4
  • 61
    • 58149523262 scopus 로고    scopus 로고
    • Alternative splicing, methylation state, and expression profile of tropomyosinrelatedkinase B in the frontal cortex of suicide completers
    • Ernst C, Deleva V, Deng X, Sequeira A, Pomarenski A, Klempan T, et al. (2009).Alternative splicing, methylation state, and expression profile of tropomyosinrelatedkinase B in the frontal cortex of suicide completers. Arch Gen Psychiatry66: 22-32.
    • (2009) Arch Gen Psychiatry , vol.66 , pp. 22-32
    • Ernst, C.1    Deleva, V.2    Deng, X.3    Sequeira, A.4    Pomarenski, A.5    Klempan, T.6
  • 62
    • 84937558111 scopus 로고    scopus 로고
    • Immune mediators in the brain and peripheraltissues in autism spectrum disorder
    • Estes ML, McAllister AK (2015). Immune mediators in the brain and peripheraltissues in autism spectrum disorder. Nat Rev Neurosci 16: 469-486.
    • (2015) Nat Rev Neurosci , vol.16 , pp. 469-486
    • Estes, M.L.1    McAllister, A.K.2
  • 63
  • 64
    • 33847099936 scopus 로고    scopus 로고
    • Astrocytes are active players in cerebral innateimmunity
    • Farina C, Aloisi F, Meinl E (2007). Astrocytes are active players in cerebral innateimmunity. Trends Immunol 28: 138-145.
    • (2007) Trends Immunol , vol.28 , pp. 138-145
    • Farina, C.1    Aloisi, F.2    Meinl, E.3
  • 65
    • 12344297883 scopus 로고    scopus 로고
    • Preferential expression and function of Toll-like receptor 3 in human astrocytes
    • Farina C, Krumbholz M, Giese T, Hartmann G, Aloisi F, Meinl E (2005). Preferentialexpression and function of Toll-like receptor 3 in human astrocytes. JNeuroimmunol 159: 12-19.
    • (2005) JNeuroimmunol , vol.159 , pp. 12-19
    • Farina, C.1    Krumbholz, M.2    Giese, T.3    Hartmann, G.4    Aloisi, F.5    Meinl, E.6
  • 66
    • 84946781649 scopus 로고    scopus 로고
    • Inflammation isassociated with decreased functional connectivity within corticostriatal rewardcircuitry in depression
    • Felger JC, Li Z, Haroon E, Woolwine BJ, Jung MY, Hu X, et al. (2016). Inflammation isassociated with decreased functional connectivity within corticostriatal rewardcircuitry in depression. Mol Psychiatry 21: 1358-1365.
    • (2016) Mol Psychiatry , vol.21 , pp. 1358-1365
    • Felger, J.C.1    Li, Z.2    Haroon, E.3    Woolwine, B.J.4    Jung, M.Y.5    Hu, X.6
  • 67
    • 84922638429 scopus 로고    scopus 로고
    • Immune activation promotes depression 1 month after diffuse brain injury: A rolefor primed microglia
    • Fenn AM, Gensel JC, Huang Y, Popovich PG, Lifshitz J, Godbout JP (2014).Immune activation promotes depression 1 month after diffuse brain injury: a rolefor primed microglia. Biol Psychiatry 76: 575-584.
    • (2014) Biol Psychiatry , vol.76 , pp. 575-584
    • Fenn, A.M.1    Gensel, J.C.2    Huang, Y.3    Popovich, P.G.4    Lifshitz, J.5    Godbout, J.P.6
  • 68
  • 69
    • 33846005877 scopus 로고    scopus 로고
    • TNFalpha and TNF receptor 1 expression in the mixedneuronal-glial cultures of hippocampal dentate gyrus exposed to glutamate ortrimethyltin
    • Figiel I, Dzwonek K (2007). TNFalpha and TNF receptor 1 expression in the mixedneuronal-glial cultures of hippocampal dentate gyrus exposed to glutamate ortrimethyltin. Brain Res 1131: 17-28.
    • (2007) Brain Res , vol.1131 , pp. 17-28
    • Figiel, I.1    Dzwonek, K.2
  • 70
    • 34247338931 scopus 로고    scopus 로고
    • Gap junctional control of glialglutamate transporter expression
    • Figiel M, Allritz C, Lehmann C, Engele J (2007). Gap junctional control of glialglutamate transporter expression. Mol Cell Neurosci 35: 130-137.
    • (2007) Mol Cell Neurosci , vol.35 , pp. 130-137
    • Figiel, M.1    Allritz, C.2    Lehmann, C.3    Engele, J.4
  • 71
    • 84890846196 scopus 로고    scopus 로고
    • Inhibition of microgliaactivation as a phenotypic assay in early drug discovery
    • Figuera-Losada M, Rojas C, Slusher BS (2014). Inhibition of microgliaactivation as a phenotypic assay in early drug discovery. J Biomol Screen 19:17-31.
    • (2014) J Biomol Screen , vol.19 , pp. 17-31
    • Figuera-Losada, M.1    Rojas, C.2    Slusher, B.S.3
  • 72
    • 84890168870 scopus 로고    scopus 로고
    • Astrocytespecificactivation of TNFR2 promotes oligodendrocyte maturation by secretion ofleukemia inhibitory factor
    • Fischer R, Wajant H, Kontermann R, Pfizenmaier K, Maier O (2014). Astrocytespecificactivation of TNFR2 promotes oligodendrocyte maturation by secretion ofleukemia inhibitory factor. Glia 62: 272-283.
    • (2014) Glia , vol.62 , pp. 272-283
    • Fischer, R.1    Wajant, H.2    Kontermann, R.3    Pfizenmaier, K.4    Maier, O.5
  • 73
    • 0021191999 scopus 로고
    • Astrocytes present myelin basic protein toencephalitogenic T-cell lines
    • Fontana A, Fierz W, Wekerle H (1984). Astrocytes present myelin basic protein toencephalitogenic T-cell lines. Nature 307: 273-276.
    • (1984) Nature , vol.307 , pp. 273-276
    • Fontana, A.1    Fierz, W.2    Wekerle, H.3
  • 74
    • 0025117928 scopus 로고
    • Immunoadjuvanticityof endotoxins and nontoxic derivatives for normal and leukemic immunocytes
    • Friedman H, Klein T, Specter S, Newton C, Nowotny A (1990). Immunoadjuvanticityof endotoxins and nontoxic derivatives for normal and leukemic immunocytes.Adv Exp Med Biol 256: 525-535.
    • (1990) Adv Exp Med Biol , vol.256 , pp. 525-535
    • Friedman, H.1    Klein, T.2    Specter, S.3    Newton, C.4    Nowotny, A.5
  • 75
    • 0036164788 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 increases activity andsurface levels of the GLAST subtype of glutamate transporter
    • Gamboa C, Ortega A (2002). Insulin-like growth factor-1 increases activity andsurface levels of the GLAST subtype of glutamate transporter. Neurochem Int 40:397-403.
    • (2002) Neurochem Int , vol.40 , pp. 397-403
    • Gamboa, C.1    Ortega, A.2
  • 76
    • 0037446654 scopus 로고    scopus 로고
    • Human T cells expressa functional ionotropic glutamate receptor GluR3, and glutamate by itself triggersintegrin-mediated adhesion to laminin and fibronectin and chemotactic migration
    • Ganor Y, Besser M, Ben-Zakay N, Unger T, Levite M (2003). Human T cells expressa functional ionotropic glutamate receptor GluR3, and glutamate by itself triggersintegrin-mediated adhesion to laminin and fibronectin and chemotactic migration.J Immunol 170: 4362-4372
    • (2003) J Immunol , vol.170 , pp. 4362-4372
    • Ganor, Y.1    Besser, M.2    Ben-Zakay, N.3    Unger, T.4    Levite, M.5
  • 77
    • 44849104439 scopus 로고    scopus 로고
    • Neuroprotective immunity: T cell-derivedglutamate endows astrocytes with a neuroprotective phenotype
    • Garg SK, Banerjee R, Kipnis J (2008). Neuroprotective immunity: T cell-derivedglutamate endows astrocytes with a neuroprotective phenotype. J Immunol 180:3866-3873.
    • (2008) J Immunol , vol.180 , pp. 3866-3873
    • Garg, S.K.1    Banerjee, R.2    Kipnis, J.3
  • 78
    • 59349121859 scopus 로고    scopus 로고
    • IFN-gamma and IL-4 differentially shapemetabolic responses and neuroprotective phenotype of astrocytes
    • Garg SK, Kipnis J, Banerjee R (2009). IFN-gamma and IL-4 differentially shapemetabolic responses and neuroprotective phenotype of astrocytes. J Neurochem108: 1155-1166.
    • (2009) J Neurochem , vol.108 , pp. 1155-1166
    • Garg, S.K.1    Kipnis, J.2    Banerjee, R.3
  • 79
    • 84943339561 scopus 로고    scopus 로고
    • Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyteprogenitors
    • Gautier HO, Evans KA, Volbracht K, James R, Sitnikov S, Lundgaard I, et al. (2015).Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyteprogenitors. Nat Commun 6: 8518.
    • (2015) Nat Commun , vol.6 , pp. 8518
    • Gautier, H.O.1    Evans, K.A.2    Volbracht, K.3    James, R.4    Sitnikov, S.5    Lundgaard, I.6
  • 80
    • 78149360132 scopus 로고    scopus 로고
    • Fatemapping analysis reveals that adult microglia derive from primitive macrophages
    • Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, et al. (2010). Fatemapping analysis reveals that adult microglia derive from primitive macrophages.Science 330: 841-845.
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1    Greter, M.2    Leboeuf, M.3    Nandi, S.4    See, P.5    Gokhan, S.6
  • 81
    • 84948845532 scopus 로고    scopus 로고
    • Prenatal immune activation causes hippocampal synaptic deficits in the absenceof overt microglia anomalies
    • Giovanoli S, Weber-Stadlbauer U, Schedlowski M, Meyer U, Engler H (2016).Prenatal immune activation causes hippocampal synaptic deficits in the absenceof overt microglia anomalies. Brain Behav Immun 55: 25-38.
    • (2016) Brain Behav Immun , vol.55 , pp. 25-38
    • Giovanoli, S.1    Weber-Stadlbauer, U.2    Schedlowski, M.3    Meyer, U.4    Engler, H.5
  • 82
    • 64649100658 scopus 로고    scopus 로고
    • Age and neuroinflammation: A lifetime ofpsychoneuroimmune consequences
    • Godbout JP, Johnson RW (2009). Age and neuroinflammation: a lifetime ofpsychoneuroimmune consequences. Immunol Allergy Clin North Am 29:321-337.
    • (2009) Immunol Allergy Clin North Am , vol.29 , pp. 321-337
    • Godbout, J.P.1    Johnson, R.W.2
  • 83
    • 49549087762 scopus 로고    scopus 로고
    • Aging exacerbates depressive-like behavior in mice in response to activation ofthe peripheral innate immune system
    • Godbout JP, Moreau M, Lestage J, Chen J, Sparkman NL, O'Connor J, et al. (2008).Aging exacerbates depressive-like behavior in mice in response to activation ofthe peripheral innate immune system. Neuropsychopharmacology 33:2341-2351.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2341-2351
    • Godbout, J.P.1    Moreau, M.2    Lestage, J.3    Chen, J.4    Sparkman, N.L.5    O'Connor, J.6
  • 84
    • 84959105839 scopus 로고    scopus 로고
    • A meta-analysis of blood cytokinenetwork alterations in psychiatric patients: Comparisons between schizophrenia,bipolar disorder and depression
    • (e-pub ahead of print
    • Goldsmith DR, Rapaport MH, Miller BJ (2016). A meta-analysis of blood cytokinenetwork alterations in psychiatric patients: comparisons between schizophrenia,bipolar disorder and depression. Mol Psychiatry (e-pub ahead of print;doi:10.1038/mp.2016.3).
    • (2016) Mol Psychiatry
    • Goldsmith, D.R.1    Rapaport, M.H.2    Miller, B.J.3
  • 85
    • 84856677157 scopus 로고    scopus 로고
    • Antidepressant-likeproperties of oral riluzole and utility of incentive disengagement models ofdepression in mice
    • Gourley SL, Espitia JW, Sanacora G, Taylor JR (2012). Antidepressant-likeproperties of oral riluzole and utility of incentive disengagement models ofdepression in mice. Psychopharmacology 219: 805-814.
    • (2012) Psychopharmacology , vol.219 , pp. 805-814
    • Gourley, S.L.1    Espitia, J.W.2    Sanacora, G.3    Taylor, J.R.4
  • 86
    • 77649184973 scopus 로고    scopus 로고
    • Microglia: Biology and pathology
    • Graeber MB, Streit WJ (2010). Microglia: biology and pathology. Acta Neuropathol119: 89-105.
    • (2010) Acta Neuropathol , vol.119 , pp. 89-105
    • Graeber, M.B.1    Streit, W.J.2
  • 87
    • 84860238593 scopus 로고    scopus 로고
    • EAATexpression by macrophages and microglia: Still more questions than answers
    • Gras G, Samah B, Hubert A, Leone C, Porcheray F, Rimaniol AC (2012). EAATexpression by macrophages and microglia: still more questions than answers.Amino Acids 42: 221-229.
    • (2012) Amino Acids , vol.42 , pp. 221-229
    • Gras, G.1    Samah, B.2    Hubert, A.3    Leone, C.4    Porcheray, F.5    Rimaniol, A.C.6
  • 88
    • 0032698232 scopus 로고    scopus 로고
    • 3-Hydroxykynurenine potentiates quinolinate but notNMDA toxicity in the rat striatum
    • Guidetti P, Schwarcz R (1999). 3-Hydroxykynurenine potentiates quinolinate but notNMDA toxicity in the rat striatum. Eur J Neurosci 11: 3857-3863.
    • (1999) Eur J Neurosci , vol.11 , pp. 3857-3863
    • Guidetti, P.1    Schwarcz, R.2
  • 89
    • 84859582577 scopus 로고    scopus 로고
    • Quinolinic acid, the inescapable neurotoxin
    • Guillemin GJ (2012). Quinolinic acid, the inescapable neurotoxin. FEBS J 279:1356-1365
    • (2012) FEBS J , vol.279 , pp. 1356-1365
    • Guillemin, G.J.1
  • 90
    • 84896975117 scopus 로고    scopus 로고
    • CXCL12 chemokine and its receptors as major players in theinteractions between immune and nervous systems
    • Guyon A (2014). CXCL12 chemokine and its receptors as major players in theinteractions between immune and nervous systems. Front Cell Neurosci 8: 65.
    • (2014) Front Cell Neurosci , vol.8 , pp. 65
    • Guyon, A.1
  • 91
    • 1542316019 scopus 로고    scopus 로고
    • Glial reduction in amygdalain major depressive disorder is due to oligodendrocytes
    • Hamidi M, Drevets WC, Price JL (2004). Glial reduction in amygdalain major depressive disorder is due to oligodendrocytes. Biol Psychiatry 55:563-569.
    • (2004) Biol Psychiatry , vol.55 , pp. 563-569
    • Hamidi, M.1    Drevets, W.C.2    Price, J.L.3
  • 92
    • 84883822520 scopus 로고    scopus 로고
    • Theneuroinflammation marker translocator protein is not elevated in individuals withmild-to-moderate depression: A [(1)(1)C]PBR28 PET study
    • Hannestad J, DellaGioia N, Gallezot JD, Lim K, Nabulsi N, Esterlis I, et al. (2013). Theneuroinflammation marker translocator protein is not elevated in individuals withmild-to-moderate depression: a [(1)(1)C]PBR28 PET study. Brain Behav Immun33: 131-138.
    • (2013) Brain Behav Immun , vol.33 , pp. 131-138
    • Hannestad, J.1    DellaGioia, N.2    Gallezot, J.D.3    Lim, K.4    Nabulsi, N.5    Esterlis, I.6
  • 93
    • 70450182118 scopus 로고    scopus 로고
    • Coupling of the NMDA receptor to neuroprotective andneurodestructive events
    • Hardingham GE (2009). Coupling of the NMDA receptor to neuroprotective andneurodestructive events. Biochem Soc Trans 37(Pt 6): 1147-1160.
    • (2009) Biochem Soc Trans , vol.37 , pp. 1147-1160
    • Hardingham, G.E.1
  • 94
    • 77956917231 scopus 로고    scopus 로고
    • Synaptic vs extrasynaptic NMDA receptorsignalling: Implications for neurodegenerative disorders
    • Hardingham GE, Bading H (2010). Synaptic vs extrasynaptic NMDA receptorsignalling: implications for neurodegenerative disorders. Nat Rev Neurosci 11:682-696
    • (2010) Nat Rev Neurosci , vol.11 , pp. 682-696
    • Hardingham, G.E.1    Bading, H.2
  • 95
    • 0036241207 scopus 로고    scopus 로고
    • Extrasynaptic NMDARs opposesynaptic NMDARs by triggering CREB shut-off and cell death pathways
    • Hardingham GE, Fukunaga Y, Bading H (2002). Extrasynaptic NMDARs opposesynaptic NMDARs by triggering CREB shut-off and cell death pathways. NatNeurosci 5: 405-414.
    • (2002) NatNeurosci , vol.5 , pp. 405-414
    • Hardingham, G.E.1    Fukunaga, Y.2    Bading, H.3
  • 96
    • 84928829265 scopus 로고    scopus 로고
    • Agerelatedincreases in basal ganglia glutamate are associated with TNF, reducedmotivation and decreased psychomotor speed during IFN-alpha treatment:preliminary findings
    • Haroon E, Felger JC, Woolwine BJ, Chen X, Parekh S, Spivey JR, et al. (2015). Agerelatedincreases in basal ganglia glutamate are associated with TNF, reducedmotivation and decreased psychomotor speed during IFN-alpha treatment:preliminary findings. Brain Behav Immun 46: 17-22.
    • (2015) Brain Behav Immun , vol.46 , pp. 17-22
    • Haroon, E.1    Felger, J.C.2    Woolwine, B.J.3    Chen, X.4    Parekh, S.5    Spivey, J.R.6
  • 97
    • 84954540029 scopus 로고    scopus 로고
    • Conceptual convergence: Increased inflammation is associated with increasedbasal ganglia glutamate in patients with major depression
    • Haroon E, Fleischer CC, Felger JC, Chen X, Woolwine BJ, Patel T, et al. (2016).Conceptual convergence: increased inflammation is associated with increasedbasal ganglia glutamate in patients with major depression. Mol Psychiatry 21:1351-1357.
    • (2016) Mol Psychiatry , vol.21 , pp. 1351-1357
    • Haroon, E.1    Fleischer, C.C.2    Felger, J.C.3    Chen, X.4    Woolwine, B.J.5    Patel, T.6
  • 98
    • 84856111463 scopus 로고    scopus 로고
    • Psychoneuroimmunology meets neuropsychopharmacology:translational implications of the impact of inflammation onbehavior
    • Haroon E, Raison CL, Miller AH (2012). Psychoneuroimmunology meets neuropsychopharmacology:translational implications of the impact of inflammation onbehavior. Neuropsychopharmacology 37: 137-162.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 137-162
    • Haroon, E.1    Raison, C.L.2    Miller, A.H.3
  • 99
    • 57749111467 scopus 로고    scopus 로고
    • Prefrontal myo-inositol concentration and visuospatial functioning among diabeticdepressed patients
    • Haroon E, Watari K, Thomas A, Ajilore O, Mintz J, Elderkin-Thompson V, et al. (2009).Prefrontal myo-inositol concentration and visuospatial functioning among diabeticdepressed patients. Psychiatry Res 171: 10-19.
    • (2009) Psychiatry Res , vol.171 , pp. 10-19
    • Haroon, E.1    Watari, K.2    Thomas, A.3    Ajilore, O.4    Mintz, J.5    Elderkin-Thompson, V.6
  • 100
    • 84900548523 scopus 로고    scopus 로고
    • IFNalpha-induced cortical and subcortical glutamate changes assessed by magneticresonance spectroscopy
    • Haroon E, Woolwine BJ, Chen X, Pace TW, Parekh S, Spivey JR, et al. (2014). IFNalpha-induced cortical and subcortical glutamate changes assessed by magneticresonance spectroscopy. Neuropsychopharmacology 39: 1777-1785
    • (2014) Neuropsychopharmacology , vol.39 , pp. 1777-1785
    • Haroon, E.1    Woolwine, B.J.2    Chen, X.3    Pace, T.W.4    Parekh, S.5    Spivey, J.R.6
  • 101
    • 84927667387 scopus 로고    scopus 로고
    • Inflammatory biomarkers as differential predictors ofantidepressant response
    • Hashimoto K (2015). Inflammatory biomarkers as differential predictors ofantidepressant response. Int J Mol Sci 16: 7796-7801.
    • (2015) Int J Mol Sci , vol.16 , pp. 7796-7801
    • Hashimoto, K.1
  • 102
    • 33745873475 scopus 로고    scopus 로고
    • Astrocyte control of synaptic transmission andneurovascular coupling
    • Haydon PG, Carmignoto G (2006). Astrocyte control of synaptic transmission andneurovascular coupling. Physiol Rev 86: 1009-1031.
    • (2006) Physiol Rev , vol.86 , pp. 1009-1031
    • Haydon, P.G.1    Carmignoto, G.2
  • 103
    • 72049117891 scopus 로고    scopus 로고
    • SDF-1alpha/CXCL12 enhances GABA and glutamatesynaptic activity at serotonin neurons in the rat dorsal raphe nucleus
    • Heinisch S, Kirby LG (2010). SDF-1alpha/CXCL12 enhances GABA and glutamatesynaptic activity at serotonin neurons in the rat dorsal raphe nucleus.Neuropharmacology 58: 501-514.
    • (2010) Neuropharmacology , vol.58 , pp. 501-514
    • Heinisch, S.1    Kirby, L.G.2
  • 104
    • 84859734572 scopus 로고    scopus 로고
    • In vitroevidence for the brain glutamate efflux hypothesis: Brain endothelial cellscocultured with astrocytes display a polarized brain-to-blood transport ofglutamate
    • Helms HC, Madelung R, Waagepetersen HS, Nielsen CU, Brodin B (2012). In vitroevidence for the brain glutamate efflux hypothesis: brain endothelial cellscocultured with astrocytes display a polarized brain-to-blood transport ofglutamate. Glia 60: 882-893.
    • (2012) Glia , vol.60 , pp. 882-893
    • Helms, H.C.1    Madelung, R.2    Waagepetersen, H.S.3    Nielsen, C.U.4    Brodin, B.5
  • 105
    • 65649152524 scopus 로고    scopus 로고
    • Associations of depression with C-reactiveprotein, IL-1, and IL-6: A meta-analysis
    • Howren MB, Lamkin DM, Suls J (2009). Associations of depression with C-reactiveprotein, IL-1, and IL-6: a meta-analysis. Psychosom Med 71: 171-186.
    • (2009) Psychosom Med , vol.71 , pp. 171-186
    • Howren, M.B.1    Lamkin, D.M.2    Suls, J.3
  • 106
    • 70449687899 scopus 로고    scopus 로고
    • Leptin receptor mRNA in rat brainastrocytes
    • Hsuchou H, Pan W, Barnes MJ, Kastin AJ (2009). Leptin receptor mRNA in rat brainastrocytes. Peptides 30: 2275-2280.
    • (2009) Peptides , vol.30 , pp. 2275-2280
    • Hsuchou, H.1    Pan, W.2    Barnes, M.J.3    Kastin, A.J.4
  • 108
    • 39149123139 scopus 로고    scopus 로고
    • Cytokine-inducedenhancement of calcium-dependent glutamate release from astrocytes mediatedby nitric oxide
    • Ida T, Hara M, Nakamura Y, Kozaki S, Tsunoda S, Ihara H (2008). Cytokine-inducedenhancement of calcium-dependent glutamate release from astrocytes mediatedby nitric oxide. Neurosci Lett 432: 232-236.
    • (2008) Neurosci Lett , vol.432 , pp. 232-236
    • Ida, T.1    Hara, M.2    Nakamura, Y.3    Kozaki, S.4    Tsunoda, S.5    Ihara, H.6
  • 109
    • 84879671420 scopus 로고    scopus 로고
    • Is there a cerebral lymphatic system?
    • Iliff JJ, Nedergaard M (2013). Is there a cerebral lymphatic system? Stroke 44(6Suppl 1): S93-S95.
    • (2013) Stroke , vol.44 , Issue.6 , pp. S93-S95
    • Iliff, J.J.1    Nedergaard, M.2
  • 110
    • 0034161522 scopus 로고    scopus 로고
    • Imaging extracellular waves of glutamateduring calcium signaling in cultured astrocytes
    • Innocenti B, Parpura V, Haydon PG (2000). Imaging extracellular waves of glutamateduring calcium signaling in cultured astrocytes. J Neurosci 20: 1800-1808.
    • (2000) J Neurosci , vol.20 , pp. 1800-1808
    • Innocenti, B.1    Parpura, V.2    Haydon, P.G.3
  • 111
    • 77954230363 scopus 로고    scopus 로고
    • Researchdomain criteria (RDoC): Toward a new classification framework for research onmental disorders
    • Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K, et al. (2010). Researchdomain criteria (RDoC): toward a new classification framework for research onmental disorders. Am J Psychiatry 167: 748-751.
    • (2010) Am J Psychiatry , vol.167 , pp. 748-751
    • Insel, T.1    Cuthbert, B.2    Garvey, M.3    Heinssen, R.4    Pine, D.S.5    Quinn, K.6
  • 112
    • 84948672272 scopus 로고    scopus 로고
    • Modulation of neuronal excitability by immunemediators in epilepsy
    • Iori V, Frigerio F, Vezzani A (2016). Modulation of neuronal excitability by immunemediators in epilepsy. Curr Opin Pharmacol 26: 118-123.
    • (2016) Curr Opin Pharmacol , vol.26 , pp. 118-123
    • Iori, V.1    Frigerio, F.2    Vezzani, A.3
  • 114
    • 84878124765 scopus 로고    scopus 로고
    • The inflammasome: Pathways linking psychologicalstress, depression, and systemic illnesses
    • Iwata M, Ota KT, Duman RS (2013). The inflammasome: pathways linking psychologicalstress, depression, and systemic illnesses. Brain Behav Immun 31: 105-114.
    • (2013) Brain Behav Immun , vol.31 , pp. 105-114
    • Iwata, M.1    Ota, K.T.2    Duman, R.S.3
  • 115
    • 84955611614 scopus 로고    scopus 로고
    • Psychological stressactivates the inflammasome via release of Adenosine Triphosphate andstimulation of the purinergic type 2X7 receptor
    • Iwata M, Ota KT, Li XY, Sakaue F, Li N, Dutheil S, et al. (2016). Psychological stressactivates the inflammasome via release of Adenosine Triphosphate andstimulation of the purinergic type 2X7 receptor. Biol Psychiatry 80: 12-22.
    • (2016) Biol Psychiatry , vol.80 , pp. 12-22
    • Iwata, M.1    Ota, K.T.2    Li, X.Y.3    Sakaue, F.4    Li, N.5    Dutheil, S.6
  • 116
    • 78649371677 scopus 로고    scopus 로고
    • Regulation of system x(c)(-)activity and expression in astrocytes by interleukin-1beta: Implications for hypoxicneuronal injury
    • Jackman NA, Uliasz TF, Hewett JA, Hewett SJ (2010). Regulation of system x(c)(-)activity and expression in astrocytes by interleukin-1beta: implications for hypoxicneuronal injury. Glia 58: 1806-1815.
    • (2010) Glia , vol.58 , pp. 1806-1815
    • Jackman, N.A.1    Uliasz, T.F.2    Hewett, J.A.3    Hewett, S.J.4
  • 117
    • 85011771231 scopus 로고    scopus 로고
    • Therapeutic modulation of glutamate receptors in major depressive disorder
    • (e-pub ahead of print; pii:CN-EPUB-74491
    • Jaso BA, Niciu MJ, Iadarola ND, Lally N, Richards EM, Park M, et al. (2016).Therapeutic modulation of glutamate receptors in major depressive disorder. CurrNeuropharmacol. (e-pub ahead of print; pii:CN-EPUB-74491)
    • (2016) Curr Neuropharmacol.
    • Jaso, B.A.1    Niciu, M.J.2    Iadarola, N.D.3    Lally, N.4    Richards, E.M.5    Park, M.6
  • 118
    • 84941808521 scopus 로고    scopus 로고
    • Glia: Guardians, gluttons,or guides for the maintenance of neuronal connectivity?
    • Jebelli J, Su W, Hopkins S, Pocock J, Garden GA (2015). Glia: guardians, gluttons,or guides for the maintenance of neuronal connectivity? Ann NY Acad Sci 1351:1-10.
    • (2015) Ann NY Acad Sci , vol.1351 , pp. 1-10
    • Jebelli, J.1    Su, W.2    Hopkins, S.3    Pocock, J.4    Garden, G.A.5
  • 119
    • 0032891616 scopus 로고    scopus 로고
    • A central role for astrocytes in theinflammatory response to beta-amyloid; Chemokines, cytokines and reactiveoxygen species are produced
    • Johnstone M, Gearing AJ, Miller KM (1999). A central role for astrocytes in theinflammatory response to beta-amyloid; chemokines, cytokines and reactiveoxygen species are produced. J Neuroimmunol 93: 182-193.
    • (1999) J Neuroimmunol , vol.93 , pp. 182-193
    • Johnstone, M.1    Gearing, A.J.2    Miller, K.M.3
  • 120
    • 2642562962 scopus 로고    scopus 로고
    • Identification of motifsinvolved in endoplasmic reticulum retention-forward trafficking of the GLT-1subtype of glutamate transporter
    • Kalandadze A, Wu Y, Fournier K, Robinson MB (2004). Identification of motifsinvolved in endoplasmic reticulum retention-forward trafficking of the GLT-1subtype of glutamate transporter. J Neurosci 24: 5183-5192.
    • (2004) J Neurosci , vol.24 , pp. 5183-5192
    • Kalandadze, A.1    Wu, Y.2    Fournier, K.3    Robinson, M.B.4
  • 121
    • 84863319545 scopus 로고    scopus 로고
    • Neuroinflammation alters voltagedependentconductance in striatal astrocytes
    • Karpuk N, Burkovetskaya M, Kielian T (2012). Neuroinflammation alters voltagedependentconductance in striatal astrocytes. J Neurophysiol 108: 112-123.
    • (2012) J Neurophysiol , vol.108 , pp. 112-123
    • Karpuk, N.1    Burkovetskaya, M.2    Kielian, T.3
  • 124
    • 84933055405 scopus 로고    scopus 로고
    • Diversity of astrocyte functions and phenotypes inneural circuits
    • Khakh BS, Sofroniew MV (2015). Diversity of astrocyte functions and phenotypes inneural circuits. Nat Neurosci 18: 942-952.
    • (2015) Nat Neurosci , vol.18 , pp. 942-952
    • Khakh, B.S.1    Sofroniew, M.V.2
  • 125
    • 1842458394 scopus 로고    scopus 로고
    • IL-1 and TNF-alpha play a pivotalrole in the host immune response in a mouse model of Staphylococcus aureusinducedexperimental brain abscess
    • Kielian T, Bearden ED, Baldwin AC, Esen N (2004). IL-1 and TNF-alpha play a pivotalrole in the host immune response in a mouse model of Staphylococcus aureusinducedexperimental brain abscess. J Neuropathol Exp Neurol 63: 381-396.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 381-396
    • Kielian, T.1    Bearden, E.D.2    Baldwin, A.C.3    Esen, N.4
  • 126
    • 2442482028 scopus 로고    scopus 로고
    • Effects of neuroinflammation on glia-glia gap junctionalintercellular communication: A perspective
    • Kielian T, Esen N (2004). Effects of neuroinflammation on glia-glia gap junctionalintercellular communication: a perspective. Neurochem Int 45: 429-436.
    • (2004) Neurochem Int , vol.45 , pp. 429-436
    • Kielian, T.1    Esen, N.2
  • 127
    • 84856225531 scopus 로고    scopus 로고
    • System x(c)(-)regulates microglia and macrophage glutamate excitotoxicity in vivo
    • Kigerl KA, Ankeny DP, Garg SK, Wei P, Guan Z, Lai W, et al. (2012). System x(c)(-)regulates microglia and macrophage glutamate excitotoxicity in vivo. Exp Neurol233: 333-341.
    • (2012) Exp Neurol , vol.233 , pp. 333-341
    • Kigerl, K.A.1    Ankeny, D.P.2    Garg, S.K.3    Wei, P.4    Guan, Z.5    Lai, W.6
  • 128
    • 23244438118 scopus 로고    scopus 로고
    • A review of the possible relevance ofinositol and the phosphatidylinositol second messenger system (PI-cycle) topsychiatric disorders-focus on magnetic resonance spectroscopy (MRS)studies
    • Kim H, McGrath BM, Silverstone PH (2005). A review of the possible relevance ofinositol and the phosphatidylinositol second messenger system (PI-cycle) topsychiatric disorders-focus on magnetic resonance spectroscopy (MRS)studies. Hum Psychopharmacol 20: 309-326.
    • (2005) Hum Psychopharmacol , vol.20 , pp. 309-326
    • Kim, H.1    McGrath, B.M.2    Silverstone, P.H.3
  • 129
    • 77957028947 scopus 로고    scopus 로고
    • Functions of astrocytes and their potential astherapeutic targets
    • Kimelberg HK, Nedergaard M (2010). Functions of astrocytes and their potential astherapeutic targets. Neurotherapeutics 7: 338-353.
    • (2010) Neurotherapeutics , vol.7 , pp. 338-353
    • Kimelberg, H.K.1    Nedergaard, M.2
  • 131
    • 27744437016 scopus 로고    scopus 로고
    • Autoantigen specific T cells inhibit glutamateuptake in astrocytes by decreasing expression of astrocytic glutamate transporterGLAST: A mechanism mediated by tumor necrosis factor-alpha
    • Korn T, Magnus T, Jung S (2005). Autoantigen specific T cells inhibit glutamateuptake in astrocytes by decreasing expression of astrocytic glutamate transporterGLAST: a mechanism mediated by tumor necrosis factor-alpha. FASEB J 19:1878-1880.
    • (2005) FASEB J , vol.19 , pp. 1878-1880
    • Korn, T.1    Magnus, T.2    Jung, S.3
  • 132
    • 84873452455 scopus 로고    scopus 로고
    • Traumatic brain injury in aged animals increases lesion size and chronically altersmicroglial/macrophage classical and alternative activation states
    • Kumar A, Stoica BA, Sabirzhanov B, Burns MP, Faden AI, Loane DJ (2013).Traumatic brain injury in aged animals increases lesion size and chronically altersmicroglial/macrophage classical and alternative activation states. Neurobiol Aging34: 1397-1411.
    • (2013) Neurobiol Aging , vol.34 , pp. 1397-1411
    • Kumar, A.1    Stoica, B.A.2    Sabirzhanov, B.3    Burns, M.P.4    Faden, A.I.5    Loane, D.J.6
  • 133
    • 33644828305 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors:their manifold roles in homeostasis and disease
    • Le Y, Zhou Y, Iribarren P, Wang J (2004). Chemokines and chemokine receptors:their manifold roles in homeostasis and disease. Cell Mol Immunol 1: 95-104.
    • (2004) Cell Mol Immunol , vol.1 , pp. 95-104
    • Le, Y.1    Zhou, Y.2    Iribarren, P.3    Wang, J.4
  • 134
    • 84864976081 scopus 로고    scopus 로고
    • Blood glutamate scavenging:insight into neuroprotection
    • Leibowitz A, Boyko M, Shapira Y, Zlotnik A (2012). Blood glutamate scavenging:insight into neuroprotection. Int J Mol Sci 13: 10041-10066.
    • (2012) Int J Mol Sci , vol.13 , pp. 10041-10066
    • Leibowitz, A.1    Boyko, M.2    Shapira, Y.3    Zlotnik, A.4
  • 135
    • 84919688241 scopus 로고    scopus 로고
    • Glutamate receptor antibodies in neurological diseases
    • Levite M (2014). Glutamate receptor antibodies in neurological diseases. J NeuralTransm (Vienna) 121: 1029-1075.
    • (2014) J NeuralTransm (Vienna) , Issue.121 , pp. 1029-1075
    • Levite, M.1
  • 136
    • 0032400828 scopus 로고    scopus 로고
    • Stoichiometry of the glial glutamate transporterGLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for lowendogenous Na+-dependent glutamate uptake
    • Levy LM, Warr O, Attwell D (1998). Stoichiometry of the glial glutamate transporterGLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for lowendogenous Na+-dependent glutamate uptake. J Neurosci 18: 9620-9628.
    • (1998) J Neurosci , vol.18 , pp. 9620-9628
    • Levy, L.M.1    Warr, O.2    Attwell, D.3
  • 137
    • 84872191631 scopus 로고    scopus 로고
    • The cystine/glutamate antiporter system x(c)(-) in health and disease: Frommolecular mechanisms to novel therapeutic opportunities
    • Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, et al. (2013).The cystine/glutamate antiporter system x(c)(-) in health and disease: frommolecular mechanisms to novel therapeutic opportunities. Antioxid Redox Signal18: 522-555.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 522-555
    • Lewerenz, J.1    Hewett, S.J.2    Huang, Y.3    Lambros, M.4    Gout, P.W.5    Kalivas, P.W.6
  • 138
    • 84954470044 scopus 로고    scopus 로고
    • Chronic glutamate toxicity in neurodegenerativediseases-what is the evidence?
    • Lewerenz J, Maher P (2015). Chronic glutamate toxicity in neurodegenerativediseases-what is the evidence? Front Neurosci 9: 469.
    • (2015) Front Neurosci , vol.9 , pp. 469
    • Lewerenz, J.1    Maher, P.2
  • 139
    • 0033514003 scopus 로고    scopus 로고
    • Net efflux of cysteine, glutathione andrelated metabolites from rat hippocampal slices during oxygen/glucose deprivation:dependence on gamma-glutamyl transpeptidase
    • Li X, Wallin C, Weber SG, Sandberg M (1999). Net efflux of cysteine, glutathione andrelated metabolites from rat hippocampal slices during oxygen/glucose deprivation:dependence on gamma-glutamyl transpeptidase. Brain Res 815: 81-88.
    • (1999) Brain Res , vol.815 , pp. 81-88
    • Li, X.1    Wallin, C.2    Weber, S.G.3    Sandberg, M.4
  • 141
    • 84940376898 scopus 로고    scopus 로고
    • SnapShot: Astrocytes in health and disease
    • e1171
    • Liddelow S, Barres B (2015). SnapShot: astrocytes in health and disease. Cell 162:1170-1170 e1171.
    • (2015) Cell , vol.162 , pp. 1170
    • Liddelow, S.1    Barres, B.2
  • 142
    • 0028896256 scopus 로고
    • Excitatory amino acid release fromastrocytes during energy failure by reversal of sodium-dependent uptake
    • Longuemare MC, Swanson RA (1995). Excitatory amino acid release fromastrocytes during energy failure by reversal of sodium-dependent uptake. JNeurosci Res 40: 379-386.
    • (1995) J Neurosci Res , vol.40 , pp. 379-386
    • Longuemare, M.C.1    Swanson, R.A.2
  • 143
    • 84936871460 scopus 로고    scopus 로고
    • Structural and functional features of central nervous system lymphatic vessels
    • Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, et al. (2015).Structural and functional features of central nervous system lymphatic vessels.Nature 523: 337-341.
    • (2015) Nature , vol.523 , pp. 337-341
    • Louveau, A.1    Smirnov, I.2    Keyes, T.J.3    Eccles, J.D.4    Rouhani, S.J.5    Peske, J.D.6
  • 144
    • 84908191331 scopus 로고    scopus 로고
    • Serine racemaseregulated by binding to stargazin and PSD-95: Potential N-methyl-D-aspartatealpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (NMDA-AMPA) glutamateneurotransmission cross-talk
    • Ma TM, Paul BD, Fu C, Hu S, Zhu H, Blackshaw S, et al. (2014). Serine racemaseregulated by binding to stargazin and PSD-95: potential N-methyl-D-aspartatealpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (NMDA-AMPA) glutamateneurotransmission cross-talk. J Biol Chem 289: 29631-29641.
    • (2014) J Biol Chem , vol.289 , pp. 29631-29641
    • Ma, T.M.1    Paul, B.D.2    Fu, C.3    Hu, S.4    Zhu, H.5    Blackshaw, S.6
  • 146
    • 67449097474 scopus 로고    scopus 로고
    • Ketamineand the next generation of antidepressants with a rapid onset of action
    • Machado-Vieira R, Salvadore G, Diazgranados N, Zarate CA Jr (2009). Ketamineand the next generation of antidepressants with a rapid onset of action.Pharmacol Ther 123: 143-150.
    • (2009) Pharmacol Ther , vol.123 , pp. 143-150
    • MacHado-Vieira, R.1    Salvadore, G.2    Diazgranados, N.3    Zarate, C.A.4
  • 147
    • 36849085955 scopus 로고    scopus 로고
    • Mechanisms of glutamate release from astrocytes
    • Malarkey EB, Parpura V (2008). Mechanisms of glutamate release from astrocytes.Neurochem Int 52: 142-154.
    • (2008) Neurochem Int , vol.52 , pp. 142-154
    • Malarkey, E.B.1    Parpura, V.2
  • 148
    • 0345104338 scopus 로고    scopus 로고
    • Role ofinterleukin-6 and soluble IL-6 receptor in region-specific induction of astrocyticdifferentiation and neurotrophin expression
    • Marz P, Heese K, Dimitriades-Schmutz B, Rose-John S, Otten U (1999). Role ofinterleukin-6 and soluble IL-6 receptor in region-specific induction of astrocyticdifferentiation and neurotrophin expression. Glia 26: 191-200.
    • (1999) Glia , vol.26 , pp. 191-200
    • Marz, P.1    Heese, K.2    Dimitriades-Schmutz, B.3    Rose-John, S.4    Otten, U.5
  • 149
    • 84954538622 scopus 로고    scopus 로고
    • Main path andbyways: Non-vesicular glutamate release by system xc(-) as an important modifierof glutamatergic neurotransmission
    • Massie A, Boillee S, Hewett S, Knackstedt L, Lewerenz J (2015). Main path andbyways: non-vesicular glutamate release by system xc(-) as an important modifierof glutamatergic neurotransmission. J Neurochem 135: 1062-1079.
    • (2015) J Neurochem , vol.135 , pp. 1062-1079
    • Massie, A.1    Boillee, S.2    Hewett, S.3    Knackstedt, L.4    Lewerenz, J.5
  • 150
  • 151
    • 80053960182 scopus 로고    scopus 로고
    • Invivo optogenetic stimulation of neocortical excitatory neurons drives brain-statedependentinhibition
    • Mateo C, Avermann M, Gentet LJ, Zhang F, Deisseroth K, Petersen CC (2011). Invivo optogenetic stimulation of neocortical excitatory neurons drives brain-statedependentinhibition. Curr Biol 21: 1593-1602.
    • (2011) Curr Biol , vol.21 , pp. 1593-1602
    • Mateo, C.1    Avermann, M.2    Gentet, L.J.3    Zhang, F.4    Deisseroth, K.5    Petersen, C.C.6
  • 152
    • 84999913217 scopus 로고    scopus 로고
    • A randomized placebo-controlled adjunctive trial of riluzole in treatment-resistant major depressiveDisorder-NCT01204918-Efficacy and tolerability of riluzole in treatmentresistant depression
    • (NCDEU
    • Mathew S, Fava M, Guerguieva R, Sanacora G(eds) (2015). A Randomized Placebo-Controlled Adjunctive Trial of Riluzole in Treatment-Resistant Major DepressiveDisorder-NCT01204918-Efficacy and Tolerability of Riluzole in TreatmentResistant Depression. ASCP Annual Meeting (NCDEU)
    • (2015) ASCP Annual Meeting
    • Mathew, S.1    Fava, M.2    Guerguieva, R.3    Sanacora, G.4
  • 153
    • 33746379857 scopus 로고    scopus 로고
    • Oligodendrocyte NMDA receptors: A novel therapeutic target
    • Miami, FL, USA.Matute C (2006). Oligodendrocyte NMDA receptors: a novel therapeutic target.Trends Mol Med 12: 289-292.
    • (2006) Trends Mol Med , vol.12 , pp. 289-292
    • Miami, F.L.1    Matute, C.2
  • 154
    • 33644797572 scopus 로고    scopus 로고
    • Glutamate-mediated glial injury:mechanisms and clinical importance
    • Matute C, Domercq M, Sanchez-Gomez MV (2006). Glutamate-mediated glial injury:mechanisms and clinical importance. Glia 53: 212-224.
    • (2006) Glia , vol.53 , pp. 212-224
    • Matute, C.1    Domercq, M.2    Sanchez-Gomez, M.V.3
  • 155
    • 84926651016 scopus 로고    scopus 로고
    • Regulation of extrasynaptic glutamate levelsas a pathophysiological mechanism in disorders of motivation and addiction
    • McCullumsmith RE, Sanacora G (2015). Regulation of extrasynaptic glutamate levelsas a pathophysiological mechanism in disorders of motivation and addiction.Neuropsychopharmacology 40: 254-255.
    • (2015) Neuropsychopharmacology , vol.40 , pp. 254-255
    • McCullumsmith, R.E.1    Sanacora, G.2
  • 156
    • 84949587661 scopus 로고    scopus 로고
    • Stress effects on neuronal structure:hippocampus, amygdala, and prefrontal cortex
    • McEwen BS, Nasca C, Gray JD (2016). Stress effects on neuronal structure:hippocampus, amygdala, and prefrontal cortex. Neuropsychopharmacology 41:3-23.
    • (2016) Neuropsychopharmacology , vol.41 , pp. 3-23
    • McEwen, B.S.1    Nasca, C.2    Gray, J.D.3
  • 159
    • 84925231252 scopus 로고    scopus 로고
    • System xC-is a mediator of microglial function and its deletion slows symptoms inamyotrophic lateral sclerosis mice
    • Mesci P, Zaidi S, Lobsiger CS, Millecamps S, Escartin C, Seilhean D, et al. (2015).System xC-is a mediator of microglial function and its deletion slows symptoms inamyotrophic lateral sclerosis mice. Brain 138(Pt 1): 53-68.
    • (2015) Brain , vol.138 , pp. 53-68
    • Mesci, P.1    Zaidi, S.2    Lobsiger, C.S.3    Millecamps, S.4    Escartin, C.5    Seilhean, D.6
  • 161
    • 84952342629 scopus 로고    scopus 로고
    • The role of inflammation in depression: Fromevolutionary imperative to modern treatment target
    • Miller AH, Raison CL (2016). The role of inflammation in depression: fromevolutionary imperative to modern treatment target. Nat Rev Immunol 16:22-34.
    • (2016) Nat Rev Immunol , vol.16 , pp. 22-34
    • Miller, A.H.1    Raison, C.L.2
  • 162
    • 42649097901 scopus 로고    scopus 로고
    • The effects of aging, injury and disease on microglialfunction: A case for cellular senescence
    • Miller KR, Streit WJ (2007). The effects of aging, injury and disease on microglialfunction: a case for cellular senescence. Neuron Glia Biol 3: 245-253.
    • (2007) Neuron Glia Biol , vol.3 , pp. 245-253
    • Miller, K.R.1    Streit, W.J.2
  • 164
    • 33846073198 scopus 로고    scopus 로고
    • Antidepressant-like effects ofceftriaxone in male C57BL/6J mice
    • Mineur YS, Picciotto MR, Sanacora G (2007). Antidepressant-like effects ofceftriaxone in male C57BL/6J mice. Biol Psychiatry 61: 250-252.
    • (2007) Biol Psychiatry , vol.61 , pp. 250-252
    • Mineur, Y.S.1    Picciotto, M.R.2    Sanacora, G.3
  • 165
    • 44949240517 scopus 로고    scopus 로고
    • Interferon-gamma directly induces neurotoxicity through a neuron specific,calcium-permeable complex of IFN-gamma receptor and AMPA GluR1 receptor
    • Mizuno T, Zhang G, Takeuchi H, Kawanokuchi J, Wang J, Sonobe Y, et al. (2008).Interferon-gamma directly induces neurotoxicity through a neuron specific,calcium-permeable complex of IFN-gamma receptor and AMPA GluR1 receptor.FASEB J 22: 1797-1806.
    • (2008) FASEB J , vol.22 , pp. 1797-1806
    • Mizuno, T.1    Zhang, G.2    Takeuchi, H.3    Kawanokuchi, J.4    Wang, J.5    Sonobe, Y.6
  • 166
    • 84876670027 scopus 로고    scopus 로고
    • The neuroprogressive nature of majordepressive disorder: Pathways to disease evolution and resistance, andtherapeutic implications
    • Moylan S, Maes M, Wray NR, Berk M (2013). The neuroprogressive nature of majordepressive disorder: pathways to disease evolution and resistance, andtherapeutic implications. Mol Psychiatry 18: 595-606.
    • (2013) Mol Psychiatry , vol.18 , pp. 595-606
    • Moylan, S.1    Maes, M.2    Wray, N.R.3    Berk, M.4
  • 168
    • 84924696740 scopus 로고    scopus 로고
    • Astrocyticabnormalities and global DNA methylation patterns in depression and suicide
    • Nagy C, Suderman M, Yang J, Szyf M, Mechawar N, Ernst C, et al. (2015). Astrocyticabnormalities and global DNA methylation patterns in depression and suicide. MolPsychiatry 20: 320-328.
    • (2015) MolPsychiatry , vol.20 , pp. 320-328
    • Nagy, C.1    Suderman, M.2    Yang, J.3    Szyf, M.4    Mechawar, N.5    Ernst, C.6
  • 170
    • 54849417590 scopus 로고    scopus 로고
    • Mechanisms of substrate transport-induced clustering of a glial glutamate transporter GLT-1 inastroglial-neuronal cultures
    • Nakagawa T, Otsubo Y, Yatani Y, Shirakawa H, Kaneko S (2008). Mechanisms ofsubstrate transport-induced clustering of a glial glutamate transporter GLT-1 inastroglial-neuronal cultures. Eur J Neurosci 28: 1719-1730.
    • (2008) Eur J Neurosci , vol.28 , pp. 1719-1730
    • Nakagawa, T.1    Otsubo, Y.2    Yatani, Y.3    Shirakawa, H.4    Kaneko, S.5
  • 171
    • 84876931396 scopus 로고    scopus 로고
    • Beyond oxidative stress: An immunologist'sguide to reactive oxygen species
    • Nathan C, Cunningham-Bussel A (2013). Beyond oxidative stress: an immunologist'sguide to reactive oxygen species. Nat Rev Immunol 13: 349-361
    • (2013) Nat Rev Immunol , vol.13 , pp. 349-361
    • Nathan, C.1    Cunningham-Bussel, A.2
  • 172
    • 0036718797 scopus 로고    scopus 로고
    • Beyond the role of glutamate as aneurotransmitter
    • Nedergaard M, Takano T, Hansen AJ (2002). Beyond the role of glutamate as aneurotransmitter. Nat Rev Neurosci 3: 748-755.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 748-755
    • Nedergaard, M.1    Takano, T.2    Hansen, A.J.3
  • 173
    • 84908454316 scopus 로고    scopus 로고
    • Glutamate and itsreceptors in the pathophysiology and treatment of major depressive disorder
    • Niciu MJ, Ionescu DF, Richards EM, Zarate CA Jr (2014a). Glutamate and itsreceptors in the pathophysiology and treatment of major depressive disorder. JNeural Transm 121: 907-924.
    • (2014) J Neural Transm , vol.121 , pp. 907-924
    • Niciu, M.J.1    Ionescu, D.F.2    Richards, E.M.3    Zarate, C.A.4
  • 175
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cellsare highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F (2005). Resting microglial cellsare highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 176
    • 0034001914 scopus 로고    scopus 로고
    • AMPA-kainate subtypes ofglutamate receptor in rat cerebral microglia
    • Noda M, Nakanishi H, Nabekura J, Akaike N (2000). AMPA-kainate subtypes ofglutamate receptor in rat cerebral microglia. J Neurosci 20: 251-258.
    • (2000) J Neurosci , vol.20 , pp. 251-258
    • Noda, M.1    Nakanishi, H.2    Nabekura, J.3    Akaike, N.4
  • 177
    • 84872733391 scopus 로고    scopus 로고
    • Review: Microglia of the aged brain:primed to be activated and resistant to regulation
    • Norden DM, Godbout JP (2013). Review: microglia of the aged brain:primed to be activated and resistant to regulation. Neuropathol Appl Neurobiol39: 19-34.
    • (2013) Neuropathol Appl Neurobiol , vol.39 , pp. 19-34
    • Norden, D.M.1    Godbout, J.P.2
  • 178
    • 84930926658 scopus 로고    scopus 로고
    • Microglial priming andenhanced reactivity to secondary insult in aging, and traumatic CNS injury, andneurodegenerative disease
    • Norden DM, Muccigrosso MM, Godbout JP (2015a). Microglial priming andenhanced reactivity to secondary insult in aging, and traumatic CNS injury, andneurodegenerative disease. Neuropharmacology 96(Pt A): 29-41.
    • (2015) Neuropharmacology , vol.96 , pp. 29-41
    • Norden, D.M.1    Muccigrosso, M.M.2    Godbout, J.P.3
  • 179
    • 84969277867 scopus 로고    scopus 로고
    • Insensitivity ofastrocytes to interleukin 10 signaling following peripheral immune challengeresults in prolonged microglial activation in the aged brain
    • Norden DM, Trojanowski PJ, Walker FR, Godbout JP (2016). Insensitivity ofastrocytes to interleukin 10 signaling following peripheral immune challengeresults in prolonged microglial activation in the aged brain. Neurobiol Aging 44:22-41.
    • (2016) Neurobiol Aging , vol.44 , pp. 22-41
    • Norden, D.M.1    Trojanowski, P.J.2    Walker, F.R.3    Godbout, J.P.4
  • 180
    • 85029240687 scopus 로고    scopus 로고
    • Age-relatedimpairments in the dynamic regulation of active microglia by astrocytes
    • Norden DM, Trojanowski PT, Walker FR, Godbout JP (2015b). Age-relatedimpairments in the dynamic regulation of active microglia by astrocytes. BrainBehav Immun 49: e16-e17.
    • (2015) BrainBehav Immun , vol.49 , pp. e16-e17
    • Norden, D.M.1    Trojanowski, P.T.2    Walker, F.R.3    Godbout, J.P.4
  • 181
    • 0036228051 scopus 로고    scopus 로고
    • Altered expression of glutamate transporters in experimental autoimmuneencephalomyelitis
    • Ohgoh M, Hanada T, Smith T, Hashimoto T, Ueno M, Yamanishi Y, et al. (2002).Altered expression of glutamate transporters in experimental autoimmuneencephalomyelitis. J Neuroimmunol 125: 170-178.
    • (2002) J Neuroimmunol , vol.125 , pp. 170-178
    • Ohgoh, M.1    Hanada, T.2    Smith, T.3    Hashimoto, T.4    Ueno, M.5    Yamanishi, Y.6
  • 182
    • 0027468201 scopus 로고
    • Vulnerability of oligodendrogliato glutamate: Pharmacology, mechanisms, and prevention
    • Oka A, Belliveau MJ, Rosenberg PA, Volpe JJ (1993). Vulnerability of oligodendrogliato glutamate: pharmacology, mechanisms, and prevention. J Neurosci 13:1441-1453.
    • (1993) J Neurosci , vol.13 , pp. 1441-1453
    • Oka, A.1    Belliveau, M.J.2    Rosenberg, P.A.3    Volpe, J.J.4
  • 183
    • 84902144244 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha: A link betweenneuroinflammation and excitotoxicity
    • Olmos G, Llado J (2014). Tumor necrosis factor alpha: a link betweenneuroinflammation and excitotoxicity. Mediators Inflamm 2014: 861231.
    • (2014) Mediators Inflamm , vol.2014 , pp. 861231
    • Olmos, G.1    Llado, J.2
  • 185
    • 0032573166 scopus 로고    scopus 로고
    • Glial reduction in the subgenual prefrontalcortex in mood disorders
    • Ongur D, Drevets WC, Price JL (1998). Glial reduction in the subgenual prefrontalcortex in mood disorders. Proc Natl Acad Sci USA 95: 13290-13295.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13290-13295
    • Ongur, D.1    Drevets, W.C.2    Price, J.L.3
  • 186
    • 84874021086 scopus 로고    scopus 로고
    • Interferon-gamma-inducible inflammation: Contribution to aging and aging-associated psychiatric disorders
    • MDD and BD
    • MDD and BD.Oxenkrug G (2011). Interferon-gamma-inducible inflammation:contribution to aging and aging-associated psychiatric disorders. Aging Dis 2:474-486.
    • (2011) Aging Dis , vol.2 , pp. 474-486
    • Oxenkrug, G.1
  • 187
    • 77954023854 scopus 로고    scopus 로고
    • Metabolic syndrome, age-associated neuroendocrinedisorders, and dysregulation of tryptophan-kynurenine metabolism
    • Oxenkrug GF (2010). Metabolic syndrome, age-associated neuroendocrinedisorders, and dysregulation of tryptophan-kynurenine metabolism. Ann NY AcadSci 1199: 1-14.
    • (2010) Ann NY AcadSci , vol.1199 , pp. 1-14
    • Oxenkrug, G.F.1
  • 188
    • 84864855681 scopus 로고    scopus 로고
    • Leptinaction on nonneuronal cells in the CNS: Potential clinical applications
    • Pan W, Hsuchou H, Jayaram B, Khan RS, Huang EY, Wu X, et al. (2012). Leptinaction on nonneuronal cells in the CNS: potential clinical applications. Ann NYAcad Sci 1264: 64-71.
    • (2012) Ann NYAcad Sci , vol.1264 , pp. 64-71
    • Pan, W.1    Hsuchou, H.2    Jayaram, B.3    Khan, R.S.4    Huang, E.Y.5    Wu, X.6
  • 189
    • 84876685085 scopus 로고    scopus 로고
    • Astroglial amino acid-based transmitter receptors
    • Parpura V, Verkhratsky A (2013). Astroglial amino acid-based transmitter receptors.Amino Acids 44: 1151-1158.
    • (2013) Amino Acids , vol.44 , pp. 1151-1158
    • Parpura, V.1    Verkhratsky, A.2
  • 190
    • 0034743201 scopus 로고    scopus 로고
    • Spontaneous astrocytic Ca2+ oscillationsin situ drive NMDAR-mediated neuronal excitation
    • Parri HR, Gould TM, Crunelli V (2001). Spontaneous astrocytic Ca2+ oscillationsin situ drive NMDAR-mediated neuronal excitation. Nat Neurosci 4: 803-812.
    • (2001) Nat Neurosci , vol.4 , pp. 803-812
    • Parri, H.R.1    Gould, T.M.2    Crunelli, V.3
  • 191
    • 20144381062 scopus 로고    scopus 로고
    • Lipopolysaccharideincreases microglial GLT-1 expression and glutamate uptake capacity in vitro by amechanism dependent on TNF-alpha
    • Persson M, Brantefjord M, Hansson E, Ronnback L (2005). Lipopolysaccharideincreases microglial GLT-1 expression and glutamate uptake capacity in vitro by amechanism dependent on TNF-alpha. Glia 51: 111-120.
    • (2005) Glia , vol.51 , pp. 111-120
    • Persson, M.1    Brantefjord, M.2    Hansson, E.3    Ronnback, L.4
  • 192
    • 84951011800 scopus 로고    scopus 로고
    • Novel insights into gliotransmitters
    • Petrelli F, Bezzi P (2016). Novel insights into gliotransmitters. Curr Opin Pharmacol26: 138-145
    • (2016) Curr Opin Pharmacol , vol.26 , pp. 138-145
    • Petrelli, F.1    Bezzi, P.2
  • 193
    • 0028297676 scopus 로고
    • Involvement of the cystine transport system xc-in themacrophage-induced glutamate-dependent cytotoxicity to neurons
    • Piani D, Fontana A (1994). Involvement of the cystine transport system xc-in themacrophage-induced glutamate-dependent cytotoxicity to neurons. J Immunol152: 3578-3585.
    • (1994) J Immunol , vol.152 , pp. 3578-3585
    • Piani, D.1    Fontana, A.2
  • 194
    • 0025720505 scopus 로고
    • Murine brain macrophagesinduced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate
    • Piani D, Frei K, Do KQ, Cuenod M, Fontana A (1991). Murine brain macrophagesinduced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate.Neurosci Lett 133: 159-162.
    • (1991) Neurosci Lett , vol.133 , pp. 159-162
    • Piani, D.1    Frei, K.2    Do, K.Q.3    Cuenod, M.4    Fontana, A.5
  • 195
    • 81055157599 scopus 로고    scopus 로고
    • Positive allosteric modulation ofmetabotropic glutamate receptor 5 down-regulates fibrinogen-activated microgliaproviding neuronal protection
    • Piers TM, Heales SJ, Pocock JM (2011). Positive allosteric modulation ofmetabotropic glutamate receptor 5 down-regulates fibrinogen-activated microgliaproviding neuronal protection. Neurosci Lett 505: 140-145.
    • (2011) Neurosci Lett , vol.505 , pp. 140-145
    • Piers, T.M.1    Heales, S.J.2    Pocock, J.M.3
  • 197
    • 84964906124 scopus 로고    scopus 로고
    • Elevated myo-inositol, choline, and glutamate levels inthe associative striatum of antipsychotic-naive patients with first-episodepsychosis: A proton magnetic resonance spectroscopy study with implicationsfor glial dysfunction
    • Plitman E, de la Fuente-Sandoval C, Reyes-Madrigal F, Chavez S, Gomez-Cruz G,Leon-Ortiz P, et al. (2016). Elevated myo-inositol, choline, and glutamate levels inthe associative striatum of antipsychotic-naive patients with first-episodepsychosis: a proton magnetic resonance spectroscopy study with implicationsfor glial dysfunction. Schizophr Bull 42: 415-424.
    • (2016) Schizophr Bull , vol.42 , pp. 415-424
    • Plitman, E.1    De La Fuente-Sandoval, C.2    Reyes-Madrigal, F.3    Chavez, S.4    Gomez-Cruz Gleon-Ortiz, P.5
  • 198
    • 34848843543 scopus 로고    scopus 로고
    • Neurotransmitter receptors on microglia
    • Pocock JM, Kettenmann H (2007). Neurotransmitter receptors on microglia. TrendsNeurosci 30: 527-535.
    • (2007) TrendsNeurosci , vol.30 , pp. 527-535
    • Pocock, J.M.1    Kettenmann, H.2
  • 199
    • 84155160658 scopus 로고    scopus 로고
    • The stressed synapse: Theimpact of stress and glucocorticoids on glutamate transmission
    • Popoli M, Yan Z, McEwen BS, Sanacora G (2012). The stressed synapse: theimpact of stress and glucocorticoids on glutamate transmission. Nat RevNeurosci 13: 22-37.
    • (2012) Nat RevNeurosci , vol.13 , pp. 22-37
    • Popoli, M.1    Yan, Z.2    McEwen, B.S.3    Sanacora, G.4
  • 200
    • 84894049144 scopus 로고    scopus 로고
    • Neuroimmune regulation of homeostatic synapticplasticity
    • Pribiag H, Stellwagen D (2014). Neuroimmune regulation of homeostatic synapticplasticity. Neuropharmacology 78: 13-22.
    • (2014) Neuropharmacology , vol.78 , pp. 13-22
    • Pribiag, H.1    Stellwagen, D.2
  • 202
    • 77950022119 scopus 로고    scopus 로고
    • CSF concentrations of brain tryptophan and kynurenines during immunestimulation with IFN-alpha: Relationship to CNS immune responses anddepression
    • Raison CL, Dantzer R, Kelley KW, Lawson MA, Woolwine BJ, Vogt G, et al. (2010).CSF concentrations of brain tryptophan and kynurenines during immunestimulation with IFN-alpha: relationship to CNS immune responses anddepression. Mol Psychiatry 15: 393-403.
    • (2010) Mol Psychiatry , vol.15 , pp. 393-403
    • Raison, C.L.1    Dantzer, R.2    Kelley, K.W.3    Lawson, M.A.4    Woolwine, B.J.5    Vogt, G.6
  • 203
    • 84929515985 scopus 로고    scopus 로고
    • Oligodendrocyte morphometry and expression of myelin-Related mRNAin ventral prefrontal white matter in major depressive disorder
    • Rajkowska G, Mahajan G, Maciag D, Sathyanesan M, Iyo AH, Moulana M, et al.(2015). Oligodendrocyte morphometry and expression of myelin-Related mRNAin ventral prefrontal white matter in major depressive disorder. J Psychiatr Res 65:53-62.
    • (2015) J Psychiatr Res , vol.65 , pp. 53-62
    • Rajkowska, G.1    Mahajan, G.2    MacIag, D.3    Sathyanesan, M.4    Iyo, A.H.5    Moulana, M.6
  • 206
    • 84886676044 scopus 로고    scopus 로고
    • Astrocyte pathology in major depressivedisorder: Insights from human postmortem brain tissue
    • Rajkowska G, Stockmeier CA (2013). Astrocyte pathology in major depressivedisorder: insights from human postmortem brain tissue. Curr Drug Targets 14:1225-1236.
    • (2013) Curr Drug Targets , vol.14 , pp. 1225-1236
    • Rajkowska, G.1    Stockmeier, C.A.2
  • 207
    • 84979730436 scopus 로고    scopus 로고
    • A polarizing question: Do M1 and M2 microglia exist?
    • Ransohoff RM (2016). A polarizing question: do M1 and M2 microglia exist? NatNeurosci 19: 987-991
    • (2016) Nat Neurosci , vol.19 , pp. 987-991
    • Ransohoff, R.M.1
  • 208
    • 34250870091 scopus 로고    scopus 로고
    • Variations in promoter activity reveal a differential expression and physiology ofglutamate transporters by glia in the developing and mature CNS
    • Regan MR, Huang YH, Kim YS, Dykes-Hoberg MI, Jin L, Watkins AM, et al. (2007).Variations in promoter activity reveal a differential expression and physiology ofglutamate transporters by glia in the developing and mature CNS. J Neurosci 27:6607-6619.
    • (2007) J Neurosci , vol.27 , pp. 6607-6619
    • Regan, M.R.1    Huang, Y.H.2    Kim, Y.S.3    Dykes-Hoberg, M.I.4    Jin, L.5    Watkins, A.M.6
  • 209
    • 84930197296 scopus 로고    scopus 로고
    • Therole of inflammation and microglial activation in the pathophysiology of psychiatricdisorders
    • Reus GZ, Fries GR, Stertz L, Badawy M, Passos IC, Barichello T, et al. (2015). Therole of inflammation and microglial activation in the pathophysiology of psychiatricdisorders. Neuroscience 300: 141-154.
    • (2015) Neuroscience , vol.300 , pp. 141-154
    • Reus, G.Z.1    Fries, G.R.2    Stertz, L.3    Badawy, M.4    Passos, I.C.5    Barichello, T.6
  • 210
    • 0032751563 scopus 로고    scopus 로고
    • Reference distributionsfor the negative acute-phase proteins, albumin, transferrin, and transthyretin: Comparison of a large cohort to the world's literature
    • Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O (1999). Reference distributionsfor the negative acute-phase proteins, albumin, transferrin, and transthyretin: comparison of a large cohort to the world's literature. J Clin Lab Anal 13:280-286.
    • (1999) J Clin Lab Anal , vol.13 , pp. 280-286
    • Ritchie, R.F.1    Palomaki, G.E.2    Neveux, L.M.3    Navolotskaia, O.4
  • 211
    • 84931564272 scopus 로고    scopus 로고
    • Astrocyte physiopathology: At the crossroads of intercellular networking, inflammation and cell death
    • Rossi D (2015). Astrocyte physiopathology: at the crossroads of intercellularnetworking, inflammation and cell death. Prog Neurobiol 130: 86-120.
    • (2015) Prog Neurobiol , vol.130 , pp. 86-120
    • Rossi, D.1
  • 212
    • 0034688312 scopus 로고    scopus 로고
    • Glutamate release in severe brain ischaemia ismainly by reversed uptake
    • Rossi DJ, Oshima T, Attwell D (2000). Glutamate release in severe brain ischaemia ismainly by reversed uptake. Nature 403: 316-321.
    • (2000) Nature , vol.403 , pp. 316-321
    • Rossi, D.J.1    Oshima, T.2    Attwell, D.3
  • 213
    • 0029847118 scopus 로고    scopus 로고
    • Excitotoxicity hypothesis
    • Rothstein JD (1996). Excitotoxicity hypothesis. Neurology 47(4 Suppl 2): S19-S25.
    • (1996) Neurology , vol.47 , Issue.4 , pp. S19-S25
    • Rothstein, J.D.1
  • 214
    • 84961710154 scopus 로고    scopus 로고
    • Riluzole combination therapy for moderate-to-severemajor depressive disorder: A randomized, double-blind, placebo-controlled trial
    • Salardini E, Zeinoddini A, Mohammadinejad P, Khodaie-Ardakani MR, Zahraei N,Zeinoddini A, et al. (2016). Riluzole combination therapy for moderate-to-severemajor depressive disorder: a randomized, double-blind, placebo-controlled trial. JPsychiatr Res 75: 24-30.
    • (2016) JPsychiatr Res , vol.75 , pp. 24-30
    • Salardini, E.1    Zeinoddini, A.2    Mohammadinejad, P.3    Khodaie-Ardakani, M.R.4    Zahraei, N.5    Zeinoddini, A.6
  • 215
  • 216
    • 84878379500 scopus 로고    scopus 로고
    • From pathophysiology to novel antidepressant drugs:glial contributions to the pathology and treatment of mood disorders
    • Sanacora G, Banasr M (2013). From pathophysiology to novel antidepressant drugs:glial contributions to the pathology and treatment of mood disorders. BiolPsychiatry 73: 1172-1179.
    • (2013) BiolPsychiatry , vol.73 , pp. 1172-1179
    • Sanacora, G.1    Banasr, M.2
  • 217
    • 80054116238 scopus 로고    scopus 로고
    • Towards a glutamate hypothesis ofdepression: An emerging frontier of neuropsychopharmacology for mooddisorders
    • Sanacora G, Treccani G, Popoli M (2012). Towards a glutamate hypothesis ofdepression: an emerging frontier of neuropsychopharmacology for mooddisorders. Neuropharmacology 62: 63-77.
    • (2012) Neuropharmacology , vol.62 , pp. 63-77
    • Sanacora, G.1    Treccani, G.2    Popoli, M.3
  • 218
    • 84943405909 scopus 로고    scopus 로고
    • Imagingrobust microglial activation after lipopolysaccharide administration in humanswith PET
    • Sandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, et al. (2015). Imagingrobust microglial activation after lipopolysaccharide administration in humanswith PET. Proc Natl Acad Sci USA 112: 12468-12473.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 12468-12473
    • Sandiego, C.M.1    Gallezot, J.D.2    Pittman, B.3    Nabulsi, N.4    Lim, K.5    Lin, S.F.6
  • 219
    • 79952234841 scopus 로고    scopus 로고
    • TNFalpha controls glutamatergicgliotransmission in the hippocampal dentate gyrus
    • Santello M, Bezzi P, Volterra A (2011). TNFalpha controls glutamatergicgliotransmission in the hippocampal dentate gyrus. Neuron 69: 988-1001.
    • (2011) Neuron , vol.69 , pp. 988-1001
    • Santello, M.1    Bezzi, P.2    Volterra, A.3
  • 220
    • 84866751526 scopus 로고    scopus 로고
    • TNFalpha in synaptic function: Switching gears
    • Santello M, Volterra A (2012). TNFalpha in synaptic function: switching gears. TrendsNeurosci 35: 638-647.
    • (2012) TrendsNeurosci , vol.35 , pp. 638-647
    • Santello, M.1    Volterra, A.2
  • 221
    • 84927126178 scopus 로고    scopus 로고
    • Putative neuroprotective and neurotoxic kynurenine pathway metabolites areassociated with hippocampal and amygdalar volumes in subjects with majordepressive disorder
    • Savitz J, Drevets WC, Smith CM, Victor TA, Wurfel BE, Bellgowan PS, et al. (2015).Putative neuroprotective and neurotoxic kynurenine pathway metabolites areassociated with hippocampal and amygdalar volumes in subjects with majordepressive disorder. Neuropsychopharmacology 40: 463-471.
    • (2015) Neuropsychopharmacology , vol.40 , pp. 463-471
    • Savitz, J.1    Drevets, W.C.2    Smith, C.M.3    Victor, T.A.4    Wurfel, B.E.5    Bellgowan, P.S.6
  • 222
    • 84943279510 scopus 로고    scopus 로고
    • Microglia function in central nervous systemdevelopment and plasticity
    • Schafer DP, Stevens B (2015). Microglia function in central nervous systemdevelopment and plasticity. Cold Spring Harb Perspect Biol 7: a020545.
    • (2015) Cold Spring Harb Perspect Biol , vol.7 , pp. a020545
    • Schafer, D.P.1    Stevens, B.2
  • 223
    • 0036459226 scopus 로고    scopus 로고
    • CNS region-specific regulation ofglial glutamate transporter expression
    • Schluter K, Figiel M, Rozyczka J, Engele J (2002). CNS region-specific regulation ofglial glutamate transporter expression. Eur J Neurosci 16: 836-842.
    • (2002) Eur J Neurosci , vol.16 , pp. 836-842
    • Schluter, K.1    Figiel, M.2    Rozyczka, J.3    Engele, J.4
  • 224
    • 0742323784 scopus 로고    scopus 로고
    • The kynurenine pathway of tryptophan degradation as adrug target
    • Schwarcz R (2004). The kynurenine pathway of tryptophan degradation as adrug target. Curr Opin Pharmacol 4: 12-17.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 12-17
    • Schwarcz, R.1
  • 225
    • 84960154325 scopus 로고    scopus 로고
    • Kynurenines and glutamate: Multiple links and therapeuticimplications
    • Schwarcz R (2016). Kynurenines and glutamate: multiple links and therapeuticimplications. Adv Pharmacol 76: 13-37
    • (2016) Adv Pharmacol , vol.76 , pp. 13-37
    • Schwarcz, R.1
  • 226
    • 84862603083 scopus 로고    scopus 로고
    • Kynurenines in themammalian brain: When physiology meets pathology
    • Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ (2012). Kynurenines in themammalian brain: when physiology meets pathology. Nat Rev Neurosci 13:465-477.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 465-477
    • Schwarcz, R.1    Bruno, J.P.2    Muchowski, P.J.3    Wu, H.Q.4
  • 227
    • 0036784518 scopus 로고    scopus 로고
    • Manipulation of brain kynurenines: Glial targets,neuronal effects, and clinical opportunities
    • Schwarcz R, Pellicciari R (2002). Manipulation of brain kynurenines: glial targets,neuronal effects, and clinical opportunities. J Pharmacol Exp Ther 303: 1-10.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 1-10
    • Schwarcz, R.1    Pellicciari, R.2
  • 228
    • 68749087317 scopus 로고    scopus 로고
    • Global brain gene expression analysis links glutamatergic and GABAergicalterations to suicide and major depression
    • Sequeira A, Mamdani F, Ernst C, Vawter MP, Bunney WE, Lebel V, et al. (2009).Global brain gene expression analysis links glutamatergic and GABAergicalterations to suicide and major depression. PLoS One 4: e6585.
    • (2009) PLoS One , vol.4 , pp. e6585
    • Sequeira, A.1    Mamdani, F.2    Ernst, C.3    Vawter, M.P.4    Bunney, W.E.5    Lebel, V.6
  • 229
    • 84925357658 scopus 로고    scopus 로고
    • Role of translocator protein density, a marker of neuroinflammation, in the brainduring major depressive episodes
    • Setiawan E, Wilson AA, Mizrahi R, Rusjan PM, Miler L, Rajkowska G, et al. (2015).Role of translocator protein density, a marker of neuroinflammation, in the brainduring major depressive episodes. JAMA Psychiatry 72: 268-275.
    • (2015) JAMA Psychiatry , vol.72 , pp. 268-275
    • Setiawan, E.1    Wilson, A.A.2    Mizrahi, R.3    Rusjan, P.M.4    Miler, L.5    Rajkowska, G.6
  • 231
    • 34548436564 scopus 로고    scopus 로고
    • The postsynaptic architecture of excitatorysynapses: A more quantitative view
    • Sheng M, Hoogenraad CC (2007). The postsynaptic architecture of excitatorysynapses: a more quantitative view. Annu Rev Biochem 76: 823-847.
    • (2007) Annu Rev Biochem , vol.76 , pp. 823-847
    • Sheng, M.1    Hoogenraad, C.C.2
  • 232
    • 0030240326 scopus 로고    scopus 로고
    • The central nervous system as an immunocompetentorgan: Role of glial cells in antigen presentation
    • Shrikant P, Benveniste EN (1996). The central nervous system as an immunocompetentorgan: role of glial cells in antigen presentation. J Immunol 157:1819-1822.
    • (1996) J Immunol , vol.157 , pp. 1819-1822
    • Shrikant, P.1    Benveniste, E.N.2
  • 234
    • 0032403504 scopus 로고    scopus 로고
    • Astrocytesexpress elements of the class II endocytic pathway and process central nervoussystem autoantigen for presentation to encephalitogenic T cells
    • Soos JM, Morrow J, Ashley TA, Szente BE, Bikoff EK, Zamvil SS (1998). Astrocytesexpress elements of the class II endocytic pathway and process central nervoussystem autoantigen for presentation to encephalitogenic T cells. J Immunol 161:5959-5966.
    • (1998) J Immunol , vol.161 , pp. 5959-5966
    • Soos, J.M.1    Morrow, J.2    Ashley, T.A.3    Szente, B.E.4    Bikoff, E.K.5    Zamvil, S.S.6
  • 235
    • 0025073281 scopus 로고
    • Regulation of nerve growth factor (NGF) synthesis in the rat centralnervous system: Comparison between the effects of interleukin-1 and variousgrowth factors in astrocyte cultures and in vivo
    • Spranger M, Lindholm D, Bandtlow C, Heumann R, Gnahn H, Naher-Noe M, et al.(1990). Regulation of nerve growth factor (NGF) synthesis in the rat centralnervous system: comparison between the effects of interleukin-1 and variousgrowth factors in astrocyte cultures and in vivo. Eur J Neurosci 2: 69-76.
    • (1990) Eur J Neurosci , vol.2 , pp. 69-76
    • Spranger, M.1    Lindholm, D.2    Bandtlow, C.3    Heumann, R.4    Gnahn, H.5    Naher-Noe, M.6
  • 236
    • 84859610302 scopus 로고    scopus 로고
    • Kynurenine pathway inhibition as atherapeutic strategy for neuroprotection
    • Stone TW, Forrest CM, Darlington LG (2012). Kynurenine pathway inhibition as atherapeutic strategy for neuroprotection. FEBS J 279: 1386-1397.
    • (2012) FEBS J , vol.279 , pp. 1386-1397
    • Stone, T.W.1    Forrest, C.M.2    Darlington, L.G.3
  • 238
    • 84858336871 scopus 로고    scopus 로고
    • Gap junction dysfunction in theprefrontal cortex induces depressive-like behaviors in rats
    • Sun JD, Liu Y, Yuan YH, Li J, Chen NH (2012). Gap junction dysfunction in theprefrontal cortex induces depressive-like behaviors in rats. Neuropsychopharmacology37: 1305-1320.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 1305-1320
    • Sun, J.D.1    Liu, Y.2    Yuan, Y.H.3    Li, J.4    Chen, N.H.5
  • 239
    • 0033945533 scopus 로고    scopus 로고
    • Human T-cell lymphotropic virus type 1-infected T lymphocytes impair catabolismand uptake of glutamate by astrocytes via Tax-1 and tumor necrosis factor alpha
    • Szymocha R, Akaoka H, Dutuit M, Malcus C, Didier-Bazes M, Belin MF, et al. (2000).Human T-cell lymphotropic virus type 1-infected T lymphocytes impair catabolismand uptake of glutamate by astrocytes via Tax-1 and tumor necrosis factor alpha.J Virol 74: 6433-6441.
    • (2000) J Virol , vol.74 , pp. 6433-6441
    • Szymocha, R.1    Akaoka, H.2    Dutuit, M.3    Malcus, C.4    Didier-Bazes, M.5    Belin, M.F.6
  • 240
    • 0038416100 scopus 로고    scopus 로고
    • Interleukin-1betapromotes oligodendrocyte death through glutamate excitotoxicity
    • Takahashi JL, Giuliani F, Power C, Imai Y, Yong VW (2003a). Interleukin-1betapromotes oligodendrocyte death through glutamate excitotoxicity. Ann Neurol 53:588-595.
    • (2003) Ann Neurol , vol.53 , pp. 588-595
    • Takahashi, J.L.1    Giuliani, F.2    Power, C.3    Imai, Y.4    Yong, V.W.5
  • 241
    • 84940467182 scopus 로고    scopus 로고
    • Glutamate transporter EAAT2: Regulation,function, and potential as a therapeutic target for neurological and psychiatricdisease
    • Takahashi K, Foster JB, Lin CL (2015). Glutamate transporter EAAT2: regulation,function, and potential as a therapeutic target for neurological and psychiatricdisease. Cell Mol Life Sci 72: 3489-3506.
    • (2015) Cell Mol Life Sci , vol.72 , pp. 3489-3506
    • Takahashi, K.1    Foster, J.B.2    Lin, C.L.3
  • 242
    • 0242418160 scopus 로고    scopus 로고
    • Experience strengthening transmissionby driving AMPA receptors into synapses
    • Takahashi T, Svoboda K, Malinow R (2003b). Experience strengthening transmissionby driving AMPA receptors into synapses. Science 299: 1585-1588.
    • (2003) Science , vol.299 , pp. 1585-1588
    • Takahashi, T.1    Svoboda, K.2    Malinow, R.3
  • 243
    • 84874014729 scopus 로고    scopus 로고
    • L-glutamatereleased from activated microglia downregulates astrocytic L-glutamate transporterexpression in neuroinflammation: The 'collusion' hypothesis for increasedextracellular L-glutamate concentration in neuroinflammation
    • Takaki J, Fujimori K, Miura M, Suzuki T, Sekino Y, Sato K (2012). L-glutamatereleased from activated microglia downregulates astrocytic L-glutamate transporterexpression in neuroinflammation: the 'collusion' hypothesis for increasedextracellular L-glutamate concentration in neuroinflammation. J Neuroinflammation9: 275.
    • (2012) J Neuroinflammation , vol.9 , pp. 275
    • Takaki, J.1    Fujimori, K.2    Miura, M.3    Suzuki, T.4    Sekino, Y.5    Sato, K.6
  • 244
    • 53949120454 scopus 로고    scopus 로고
    • Blockade ofmicroglial glutamate release protects against ischemic brain injury
    • Takeuchi H, Jin S, Suzuki H, Doi Y, Liang J, Kawanokuchi J, et al. (2008). Blockade ofmicroglial glutamate release protects against ischemic brain injury. Exp Neurol214: 144-146.
    • (2008) Exp Neurol , vol.214 , pp. 144-146
    • Takeuchi, H.1    Jin, S.2    Suzuki, H.3    Doi, Y.4    Liang, J.5    Kawanokuchi, J.6
  • 245
    • 33746354022 scopus 로고    scopus 로고
    • Tumornecrosis factor-alpha induces neurotoxicity via glutamate release from hemichannelsof activated microglia in an autocrine manner
    • Takeuchi H, Jin S, Wang J, Zhang G, Kawanokuchi J, Kuno R, et al. (2006). Tumornecrosis factor-alpha induces neurotoxicity via glutamate release from hemichannelsof activated microglia in an autocrine manner. J Biol Chem 281:21362-21368.
    • (2006) J Biol Chem , vol.281 , pp. 21362-21368
    • Takeuchi, H.1    Jin, S.2    Wang, J.3    Zhang, G.4    Kawanokuchi, J.5    Kuno, R.6
  • 246
    • 84906912090 scopus 로고    scopus 로고
    • Gap junctions and hemichannels composed ofconnexins: Potential therapeutic targets for neurodegenerative diseases
    • Takeuchi H, Suzumura A (2014). Gap junctions and hemichannels composed ofconnexins: potential therapeutic targets for neurodegenerative diseases. FrontCell Neurosci 8: 189.
    • (2014) FrontCell Neurosci , vol.8 , pp. 189
    • Takeuchi, H.1    Suzumura, A.2
  • 247
    • 0036128148 scopus 로고    scopus 로고
    • Quinolinic acid stimulates synaptosomal glutamate release and inhibitsglutamate uptake into astrocytes
    • Tavares RG, Tasca CI, Santos CE, Alves LB, Porciuncula LO, Emanuelli T, et al.(2002). Quinolinic acid stimulates synaptosomal glutamate release and inhibitsglutamate uptake into astrocytes. Neurochem Int 40: 621-627.
    • (2002) Neurochem Int , vol.40 , pp. 621-627
    • Tavares, R.G.1    Tasca, C.I.2    Santos, C.E.3    Alves, L.B.4    Porciuncula, L.O.5    Emanuelli, T.6
  • 248
    • 15244350494 scopus 로고    scopus 로고
    • Stimulation of microglialmetabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alphainducedneurotoxicity in concert with microglial-derived Fas ligand
    • Taylor DL, Jones F, Kubota ES, Pocock JM (2005). Stimulation of microglialmetabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alphainducedneurotoxicity in concert with microglial-derived Fas ligand. J Neurosci 25:2952-2964.
    • (2005) J Neurosci , vol.25 , pp. 2952-2964
    • Taylor, D.L.1    Jones, F.2    Kubota, E.S.3    Pocock, J.M.4
  • 249
    • 34547435817 scopus 로고    scopus 로고
    • Neuroinflammation and regulation of glial glutamateuptake in neurological disorders
    • Tilleux S, Hermans E (2007). Neuroinflammation and regulation of glial glutamateuptake in neurological disorders. J Neurosci Res 85: 2059-2070.
    • (2007) J Neurosci Res , vol.85 , pp. 2059-2070
    • Tilleux, S.1    Hermans, E.2
  • 251
    • 84908617290 scopus 로고    scopus 로고
    • Evidence for increased microglial priming and macrophage recruitment in thedorsal anterior cingulate white matter of depressed suicides
    • Torres-Platas SG, Cruceanu C, Chen GG, Turecki G, Mechawar N (2014b).Evidence for increased microglial priming and macrophage recruitment in thedorsal anterior cingulate white matter of depressed suicides. Brain Behav Immun42: 50-59.
    • (2014) Brain Behav Immun , vol.42 , pp. 50-59
    • Torres-Platas, S.G.1    Cruceanu, C.2    Chen, G.G.3    Turecki, G.4    Mechawar, N.5
  • 253
    • 27744464859 scopus 로고    scopus 로고
    • The microglial 'activation' continuum: From innate toadaptive responses
    • Town T, Nikolic V, Tan J (2005). The microglial 'activation' continuum: from innate toadaptive responses. J Neuroinflammation 2: 24.
    • (2005) J Neuroinflammation , vol.2 , pp. 24
    • Town, T.1    Nikolic, V.2    Tan, J.3
  • 254
    • 36348975209 scopus 로고    scopus 로고
    • Glutamate transporters: Confining runawayexcitation by shaping synaptic transmission
    • Tzingounis AV, Wadiche JI (2007). Glutamate transporters: confining runawayexcitation by shaping synaptic transmission. Nat Rev Neurosci 8: 935-947.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 935-947
    • Tzingounis, A.V.1    Wadiche, J.I.2
  • 255
    • 84888317074 scopus 로고    scopus 로고
    • CRP, IL-6 and depression: A systematicreview and meta-analysis of longitudinal studies
    • Valkanova V, Ebmeier KP, Allan CL (2013). CRP, IL-6 and depression: a systematicreview and meta-analysis of longitudinal studies. J Affect Disord 150: 736-744.
    • (2013) J Affect Disord , vol.150 , pp. 736-744
    • Valkanova, V.1    Ebmeier, K.P.2    Allan, C.L.3
  • 256
  • 257
    • 34548297818 scopus 로고    scopus 로고
    • Altered glutamate reuptake in relapsing-remitting and secondary progressivemultiple sclerosis cortex: Correlation with microglia infiltration, demyelination, andneuronal and synaptic damage
    • Vercellino M, Merola A, Piacentino C, Votta B, Capello E, Mancardi GL, et al. (2007).Altered glutamate reuptake in relapsing-remitting and secondary progressivemultiple sclerosis cortex: correlation with microglia infiltration, demyelination, andneuronal and synaptic damage. J Neuropathol Exp Neurol 66: 732-739.
    • (2007) J Neuropathol Exp Neurol , vol.66 , pp. 732-739
    • Vercellino, M.1    Merola, A.2    Piacentino, C.3    Votta, B.4    Capello, E.5    Mancardi, G.L.6
  • 262
    • 84930929363 scopus 로고    scopus 로고
    • Neuromodulatory properties of inflammatorycytokines and their impact on neuronal excitability
    • Vezzani A, Viviani B (2015). Neuromodulatory properties of inflammatorycytokines and their impact on neuronal excitability. Neuropharmacology 96(Pt A):70-82.
    • (2015) Neuropharmacology , vol.96 , pp. 70-82
    • Vezzani, A.1    Viviani, B.2
  • 263
    • 78751704301 scopus 로고    scopus 로고
    • Cytokines and neuronal channels: A molecular basis forage-related decline of neuronal function?
    • Viviani B, Boraso M (2011). Cytokines and neuronal channels: a molecular basis forage-related decline of neuronal function? Exp Gerontol 46: 199-206.
    • (2011) Exp Gerontol , vol.46 , pp. 199-206
    • Viviani, B.1    Boraso, M.2
  • 264
    • 23044435896 scopus 로고    scopus 로고
    • Astrocytes, from brain glue to communicationelements: The revolution continues
    • Volterra A, Meldolesi J (2005). Astrocytes, from brain glue to communicationelements: the revolution continues. Nat Rev Neurosci 6: 626-640.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 626-640
    • Volterra, A.1    Meldolesi, J.2
  • 265
    • 84938371126 scopus 로고    scopus 로고
    • Peripheralproinflammatory markers associated with ketamine response in a preclinicalmodel of antidepressant-resistance
    • Walker AJ, Foley BM, Sutor SL, McGillivray JA, Frye MA, Tye SJ (2015). Peripheralproinflammatory markers associated with ketamine response in a preclinicalmodel of antidepressant-resistance. Behav Brain Res 293: 198-202.
    • (2015) Behav Brain Res , vol.293 , pp. 198-202
    • Walker, A.J.1    Foley, B.M.2    Sutor, S.L.3    McGillivray, J.A.4    Frye, M.A.5    Tye, S.J.6
  • 266
    • 84880331865 scopus 로고    scopus 로고
    • NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induceddepressive-like behavior in C57BL/6J mice
    • Walker AK, Budac DP, Bisulco S, Lee AW, Smith RA, Beenders B, et al. (2013).NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induceddepressive-like behavior in C57BL/6J mice. Neuropsychopharmacology 38:1609-1616.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 1609-1616
    • Walker, A.K.1    Budac, D.P.2    Bisulco, S.3    Lee, A.W.4    Smith, R.A.5    Beenders, B.6
  • 268
    • 84893554183 scopus 로고    scopus 로고
    • T cells in the central nervous system:messengers of destruction or purveyors of protection?
    • Walsh JT, Watson N, Kipnis J (2014b). T cells in the central nervous system:messengers of destruction or purveyors of protection? Immunology 141:340-344.
    • (2014) Immunology , vol.141 , pp. 340-344
    • Walsh, J.T.1    Watson, N.2    Kipnis, J.3
  • 269
    • 84886656123 scopus 로고    scopus 로고
    • Photolysis ofcaged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocyticglutamate release
    • Wang F, Smith NA, Xu Q, Goldman S, Peng W, Huang JH, et al. (2013a). Photolysis ofcaged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocyticglutamate release. J Neurosci 33: 17404-17412.
    • (2013) J Neurosci , vol.33 , pp. 17404-17412
    • Wang, F.1    Smith, N.A.2    Xu, Q.3    Goldman, S.4    Peng, W.5    Huang, J.H.6
  • 270
    • 84890660655 scopus 로고    scopus 로고
    • Dysregulation of synaptic and extrasynapticN-methyl-D-aspartate receptors induced by amyloid-beta
    • Wang ZC, Zhao J, Li S (2013b). Dysregulation of synaptic and extrasynapticN-methyl-D-aspartate receptors induced by amyloid-beta. Neurosci Bull 29:752-760.
    • (2013) Neurosci Bull , vol.29 , pp. 752-760
    • Wang, Z.C.1    Zhao, J.2    Li, S.3
  • 271
    • 84856037167 scopus 로고    scopus 로고
    • Early life stress inhibits expression of anovel innate immune pathway in the developing hippocampus
    • Wei L, Simen A, Mane S, Kaffman A (2012). Early life stress inhibits expression of anovel innate immune pathway in the developing hippocampus. Neuropsychopharmacology37: 567-580.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 567-580
    • Wei, L.1    Simen, A.2    Mane, S.3    Kaffman, A.4
  • 272
    • 0033103270 scopus 로고    scopus 로고
    • Neurotrophins and the anti-inflammatory agentsinterleukin-4 (IL-4), IL-10, IL-11 and transforming growth factor-beta1 (TGFbeta1)down-regulate T cell costimulatory molecules B7 and CD40 on cultured ratmicroglia
    • Wei R, Jonakait GM (1999). Neurotrophins and the anti-inflammatory agentsinterleukin-4 (IL-4), IL-10, IL-11 and transforming growth factor-beta1 (TGFbeta1)down-regulate T cell costimulatory molecules B7 and CD40 on cultured ratmicroglia. J Neuroimmunol 95: 8-18.
    • (1999) J Neuroimmunol , vol.95 , pp. 8-18
    • Wei, R.1    Jonakait, G.M.2
  • 273
    • 84916630503 scopus 로고    scopus 로고
    • Reward processing dysfunction inmajor depression, bipolar disorder and schizophrenia
    • Whitton AE, Treadway MT, Pizzagalli DA (2015). Reward processing dysfunction inmajor depression, bipolar disorder and schizophrenia. Curr Opin Psychiatry 28:7-12.
    • (2015) Curr Opin Psychiatry , vol.28 , pp. 7-12
    • Whitton, A.E.1    Treadway, M.T.2    Pizzagalli, D.A.3
  • 274
    • 84973595854 scopus 로고    scopus 로고
    • Integrating neuroimmunesystems in the neurobiology of depression
    • Wohleb ES, Franklin T, Iwata M, Duman RS (2016). Integrating neuroimmunesystems in the neurobiology of depression. Nat Rev Neurosci 17: 497-511.
    • (2016) Nat Rev Neurosci , vol.17 , pp. 497-511
    • Wohleb, E.S.1    Franklin, T.2    Iwata, M.3    Duman, R.S.4
  • 275
    • 84901310699 scopus 로고    scopus 로고
    • Reestablishmentof anxiety in stress-sensitized mice is caused by monocytetrafficking from the spleen to the brain
    • Wohleb ES, McKim DB, Shea DT, Powell ND, Tarr AJ, Sheridan JF, et al. (2014). Reestablishmentof anxiety in stress-sensitized mice is caused by monocytetrafficking from the spleen to the brain. Biol Psychiatry 75: 970-981.
    • (2014) Biol Psychiatry , vol.75 , pp. 970-981
    • Wohleb, E.S.1    McKim, D.B.2    Shea, D.T.3    Powell, N.D.4    Tarr, A.J.5    Sheridan, J.F.6
  • 276
    • 84921838841 scopus 로고    scopus 로고
    • The importance of glia in dealing with stress
    • Woodbury-Farina MA (2014). The importance of glia in dealing with stress. PsychiatrClin North Am 37: 679-705.
    • (2014) PsychiatrClin North Am , vol.37 , pp. 679-705
    • Woodbury-Farina, M.A.1
  • 277
    • 0038434118 scopus 로고    scopus 로고
    • Aging and glial responses tolipopolysaccharide in vitro: Greater induction of IL-1 and IL-6, but smaller inductionof neurotoxicity
    • Xie Z, Morgan TE, Rozovsky I, Finch CE (2003). Aging and glial responses tolipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller inductionof neurotoxicity. Exp Neurol 182: 135-141.
    • (2003) Exp Neurol , vol.182 , pp. 135-141
    • Xie, Z.1    Morgan, T.E.2    Rozovsky, I.3    Finch, C.E.4
  • 278
    • 84959895683 scopus 로고    scopus 로고
    • Systemic inflammationinduces anxiety disorder through CXCL12/CXCR4 pathway
    • Yang L, Wang M, Guo YY, Sun T, Li YJ, Yang Q, et al. (2016). Systemic inflammationinduces anxiety disorder through CXCL12/CXCR4 pathway. Brain Behav Immun56: 352-362.
    • (2016) Brain Behav Immun , vol.56 , pp. 352-362
    • Yang, L.1    Wang, M.2    Guo, Y.Y.3    Sun, T.4    Li, Y.J.5    Yang, Q.6
  • 279
    • 0029804572 scopus 로고    scopus 로고
    • Cytokine modulation of glial glutamate uptake: Apossible involvement of nitric oxide
    • Ye ZC, Sontheimer H (1996). Cytokine modulation of glial glutamate uptake: apossible involvement of nitric oxide. Neuroreport 7: 2181-2185.
    • (1996) Neuroreport , vol.7 , pp. 2181-2185
    • Ye, Z.C.1    Sontheimer, H.2
  • 282
  • 283
    • 0029860263 scopus 로고    scopus 로고
    • Flux coupling in a neuronal glutamatetransporter
    • Zerangue N, Kavanaugh MP (1996). Flux coupling in a neuronal glutamatetransporter. Nature 383: 634-637.
    • (1996) Nature , vol.383 , pp. 634-637
    • Zerangue, N.1    Kavanaugh, M.P.2
  • 284
    • 84924850720 scopus 로고    scopus 로고
    • Glutamate as a neurotransmitter in the healthy brain
    • Zhou Y, Danbolt NC (2014). Glutamate as a neurotransmitter in the healthy brain. JNeural Transm 121: 799-817.
    • (2014) JNeural Transm , vol.121 , pp. 799-817
    • Zhou, Y.1    Danbolt, N.C.2
  • 285
    • 72049095334 scopus 로고    scopus 로고
    • Reduced expression ofglutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, ananimal model of depression
    • Zink M, Vollmayr B, Gebicke-Haerter PJ, Henn FA (2010). Reduced expression ofglutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, ananimal model of depression. Neuropharmacology 58: 465-473.
    • (2010) Neuropharmacology , vol.58 , pp. 465-473
    • Zink, M.1    Vollmayr, B.2    Gebicke-Haerter, P.J.3    Henn, F.A.4
  • 286
    • 13844270562 scopus 로고    scopus 로고
    • TNF alpha potentiates glutamate neurotoxicity by inhibitingglutamate uptake in organotypic brain slice cultures: Neuroprotection by NFkappa B inhibition
    • Zou JY, Crews FT (2005). TNF alpha potentiates glutamate neurotoxicity by inhibitingglutamate uptake in organotypic brain slice cultures: neuroprotection by NFkappa B inhibition. Brain Res 1034: 11-24.
    • (2005) Brain Res , vol.1034 , pp. 11-24
    • Zou, J.Y.1    Crews, F.T.2


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