메뉴 건너뛰기




Volumn 39, Issue 1, 2013, Pages 19-34

Review: Microglia of the aged brain: Primed to be activated and resistant to regulation

Author keywords

Ageing; Behaviour; Brain; Inflammation; Microglia

Indexed keywords

MINOCYCLINE; ROSIGLITAZONE;

EID: 84872733391     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2012.01306.x     Document Type: Review
Times cited : (596)

References (153)
  • 1
    • 0033610079 scopus 로고    scopus 로고
    • Gene expression profile of aging and its retardation by caloric restriction
    • Lee CK, Klopp RG, Weindruch R, Prolla TA. Gene expression profile of aging and its retardation by caloric restriction. Science 1999; 285: 1390-1393
    • (1999) Science , vol.285 , pp. 1390-1393
    • Lee, C.K.1    Klopp, R.G.2    Weindruch, R.3    Prolla, T.A.4
  • 2
    • 23444443814 scopus 로고    scopus 로고
    • Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
    • Godbout JP, Chen J, Abraham J, Richwine AF, Berg BM, Kelley KW, Johnson RW. Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J 2005; 19: 1329-1331
    • (2005) FASEB J , vol.19 , pp. 1329-1331
    • Godbout, J.P.1    Chen, J.2    Abraham, J.3    Richwine, A.F.4    Berg, B.M.5    Kelley, K.W.6    Johnson, R.W.7
  • 3
    • 2542526131 scopus 로고    scopus 로고
    • Increased IL-1beta in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase
    • Maher FO, Martin DS, Lynch MA. Increased IL-1beta in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase. Neurobiol Aging 2004; 25: 795-806
    • (2004) Neurobiol Aging , vol.25 , pp. 795-806
    • Maher, F.O.1    Martin, D.S.2    Lynch, M.A.3
  • 4
    • 0038434118 scopus 로고    scopus 로고
    • Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity
    • Xie Z, Morgan TE, Rozovsky I, Finch CE. Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity. Exp Neurol 2003; 182: 135-141
    • (2003) Exp Neurol , vol.182 , pp. 135-141
    • Xie, Z.1    Morgan, T.E.2    Rozovsky, I.3    Finch, C.E.4
  • 5
    • 0032524647 scopus 로고    scopus 로고
    • Dietary supplementation with vitamin E reverses the age-related deficit in long term potentiation in dentate gyrus
    • Murray CA, Lynch MA. Dietary supplementation with vitamin E reverses the age-related deficit in long term potentiation in dentate gyrus. J Biol Chem 1998; 273: 12161-12168
    • (1998) J Biol Chem , vol.273 , pp. 12161-12168
    • Murray, C.A.1    Lynch, M.A.2
  • 6
    • 0032916578 scopus 로고    scopus 로고
    • Increased interleukin-6 expression by microglia from brain of aged mice
    • Ye SM, Johnson RW. Increased interleukin-6 expression by microglia from brain of aged mice. J Neuroimmunol 1999; 93: 139-148
    • (1999) J Neuroimmunol , vol.93 , pp. 139-148
    • Ye, S.M.1    Johnson, R.W.2
  • 7
    • 33846980461 scopus 로고    scopus 로고
    • Microglia derived from aging mice exhibit an altered inflammatory profile
    • Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 2007; 55: 412-424
    • (2007) Glia , vol.55 , pp. 412-424
    • Sierra, A.1    Gottfried-Blackmore, A.C.2    McEwen, B.S.3    Bulloch, K.4
  • 10
    • 0035720799 scopus 로고    scopus 로고
    • An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice
    • Ye SM, Johnson RW. An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice. Neuroimmunomodulation 2001; 9: 183-192
    • (2001) Neuroimmunomodulation , vol.9 , pp. 183-192
    • Ye, S.M.1    Johnson, R.W.2
  • 11
    • 13644253039 scopus 로고    scopus 로고
    • Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat
    • Maher FO, Nolan Y, Lynch MA. Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat. Neurobiol Aging 2005; 26: 717-728
    • (2005) Neurobiol Aging , vol.26 , pp. 717-728
    • Maher, F.O.1    Nolan, Y.2    Lynch, M.A.3
  • 13
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: unique stimuli, specialized responses
    • Ransohoff RM, Perry VH. Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol 2009; 27: 119-145
    • (2009) Annu Rev Immunol , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 14
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    • Hanisch UK, Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 2007; 10: 1387-1394
    • (2007) Nat Neurosci , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 15
    • 65249157852 scopus 로고    scopus 로고
    • Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
    • Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci 2009; 29: 3974-3980
    • (2009) J Neurosci , vol.29 , pp. 3974-3980
    • Wake, H.1    Moorhouse, A.J.2    Jinno, S.3    Kohsaka, S.4    Nabekura, J.5
  • 16
    • 78649976052 scopus 로고    scopus 로고
    • Microglial interactions with synapses are modulated by visual experience
    • Tremblay ME, Lowery RL, Majewska AK. Microglial interactions with synapses are modulated by visual experience. PLoS Biol 2010; 8: e1000527
    • (2010) PLoS Biol , vol.8
    • Tremblay, M.E.1    Lowery, R.L.2    Majewska, A.K.3
  • 20
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005; 308: 1314-1318
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 21
    • 0025220976 scopus 로고
    • Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
    • Lawson LJ, Perry VH, Dri P, Gordon S. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 1990; 39: 151-170
    • (1990) Neuroscience , vol.39 , pp. 151-170
    • Lawson, L.J.1    Perry, V.H.2    Dri, P.3    Gordon, S.4
  • 22
    • 0035105538 scopus 로고    scopus 로고
    • Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude
    • Mittelbronn M, Dietz K, Schluesener HJ, Meyermann R. Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude. Acta Neuropathol (Berl) 2001; 101: 249-255
    • (2001) Acta Neuropathol (Berl) , vol.101 , pp. 249-255
    • Mittelbronn, M.1    Dietz, K.2    Schluesener, H.J.3    Meyermann, R.4
  • 23
    • 0032737272 scopus 로고    scopus 로고
    • Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
    • Alliot F, Godin I, Pessac B. Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain. Brain Res Dev Brain Res 1999; 117: 145-152
    • (1999) Brain Res Dev Brain Res , vol.117 , pp. 145-152
    • Alliot, F.1    Godin, I.2    Pessac, B.3
  • 26
    • 77952484467 scopus 로고    scopus 로고
    • Proliferative response of microglia and macrophages in the adult mouse eye after optic nerve lesion
    • Wohl SG, Schmeer CW, Witte OW, Isenmann S. Proliferative response of microglia and macrophages in the adult mouse eye after optic nerve lesion. Invest Ophthalmol Vis Sci 2010; 51: 2686-2696
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 2686-2696
    • Wohl, S.G.1    Schmeer, C.W.2    Witte, O.W.3    Isenmann, S.4
  • 29
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 2007; 10: 1538-1543
    • (2007) Nat Neurosci , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 32
    • 0023949553 scopus 로고
    • Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
    • Hickey WF, Kimura H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 1988; 239: 290-292
    • (1988) Science , vol.239 , pp. 290-292
    • Hickey, W.F.1    Kimura, H.2
  • 33
    • 0035038172 scopus 로고    scopus 로고
    • Cytokine-induced sickness behavior: mechanisms and implications
    • Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y Acad Sci 2001; 933: 222-234
    • (2001) Ann N Y Acad Sci , vol.933 , pp. 222-234
    • Dantzer, R.1
  • 34
    • 0030804411 scopus 로고    scopus 로고
    • Evidence for an intramedullary prostaglandin-dependent mechanism in the activation of stress-related neuroendocrine circuitry by intravenous interleukin-1
    • Ericsson A, Arias C, Sawchenko PE. Evidence for an intramedullary prostaglandin-dependent mechanism in the activation of stress-related neuroendocrine circuitry by intravenous interleukin-1. J Neurosci 1997; 17: 7166-7179
    • (1997) J Neurosci , vol.17 , pp. 7166-7179
    • Ericsson, A.1    Arias, C.2    Sawchenko, P.E.3
  • 35
    • 45349083684 scopus 로고    scopus 로고
    • Dual modulation of synaptic transmission in the nucleus tractus solitarius by prostaglandin E2 synthesized downstream of IL-1beta
    • Marty V, El Hachmane M, Amedee T. Dual modulation of synaptic transmission in the nucleus tractus solitarius by prostaglandin E2 synthesized downstream of IL-1beta. Eur J Neurosci 2008; 27: 3132-3150
    • (2008) Eur J Neurosci , vol.27 , pp. 3132-3150
    • Marty, V.1    El Hachmane, M.2    Amedee, T.3
  • 36
    • 0033103979 scopus 로고    scopus 로고
    • Temporal and spatial relationships between lipopolysaccharide-induced expression of Fos, interleukin-1beta and inducible nitric oxide synthase in rat brain
    • Konsman JP, Kelley K, Dantzer R. Temporal and spatial relationships between lipopolysaccharide-induced expression of Fos, interleukin-1beta and inducible nitric oxide synthase in rat brain. Neuroscience 1999; 89: 535-548
    • (1999) Neuroscience , vol.89 , pp. 535-548
    • Konsman, J.P.1    Kelley, K.2    Dantzer, R.3
  • 37
    • 0027352040 scopus 로고
    • Altered antigen expression of microglia in the aged rodent CNS
    • Perry VH, Matyszak MK, Fearn S. Altered antigen expression of microglia in the aged rodent CNS. Glia 1993; 7: 60-67
    • (1993) Glia , vol.7 , pp. 60-67
    • Perry, V.H.1    Matyszak, M.K.2    Fearn, S.3
  • 38
    • 0028309624 scopus 로고
    • Effects of ageing on microglia in the normal rat brain: immunohistochemical observations
    • Ogura K, Ogawa M, Yoshida M. Effects of ageing on microglia in the normal rat brain: immunohistochemical observations. Neuroreport 1994; 5: 1224-1226
    • (1994) Neuroreport , vol.5 , pp. 1224-1226
    • Ogura, K.1    Ogawa, M.2    Yoshida, M.3
  • 39
    • 0030967157 scopus 로고    scopus 로고
    • Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits
    • Streit WJ, Sparks DL. Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits. J Mol Med 1997; 75: 130-138
    • (1997) J Mol Med , vol.75 , pp. 130-138
    • Streit, W.J.1    Sparks, D.L.2
  • 40
    • 0031960498 scopus 로고    scopus 로고
    • Microglial expression of MHC class II increases in normal aging of nonhuman primates
    • Sheffield LG, Berman NE. Microglial expression of MHC class II increases in normal aging of nonhuman primates. Neurobiol Aging 1998; 19: 47-55
    • (1998) Neurobiol Aging , vol.19 , pp. 47-55
    • Sheffield, L.G.1    Berman, N.E.2
  • 44
    • 61349193143 scopus 로고    scopus 로고
    • Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines
    • Henry CJ, Huang Y, Wynne AM, Godbout JP. Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines. Brain Behav Immun 2009; 23: 309-317
    • (2009) Brain Behav Immun , vol.23 , pp. 309-317
    • Henry, C.J.1    Huang, Y.2    Wynne, A.M.3    Godbout, J.P.4
  • 46
    • 34547749000 scopus 로고    scopus 로고
    • Inflammatory processes in the aging mouse brain: participation of dendritic cells and T-cells
    • Stichel CC, Luebbert H. Inflammatory processes in the aging mouse brain: participation of dendritic cells and T-cells. Neurobiol Aging 2007; 28: 1507-1521
    • (2007) Neurobiol Aging , vol.28 , pp. 1507-1521
    • Stichel, C.C.1    Luebbert, H.2
  • 48
    • 33750480549 scopus 로고    scopus 로고
    • The age-related attenuation in long-term potentiation is associated with microglial activation
    • Griffin R, Nally R, Nolan Y, McCartney Y, Linden J, Lynch MA. The age-related attenuation in long-term potentiation is associated with microglial activation. J Neurochem 2006; 99: 1263-1272
    • (2006) J Neurochem , vol.99 , pp. 1263-1272
    • Griffin, R.1    Nally, R.2    Nolan, Y.3    McCartney, Y.4    Linden, J.5    Lynch, M.A.6
  • 49
    • 37049032643 scopus 로고    scopus 로고
    • Age-related changes in ionized calcium-binding adapter molecule 1 immunoreactivity and protein level in the gerbil hippocampal CA1 region
    • Choi JH, Lee CH, Hwang IK, Won MH, Seong JK, Yoon YS, Lee HS, Lee IS. Age-related changes in ionized calcium-binding adapter molecule 1 immunoreactivity and protein level in the gerbil hippocampal CA1 region. J Vet Med Sci 2007; 69: 1131-1136
    • (2007) J Vet Med Sci , vol.69 , pp. 1131-1136
    • Choi, J.H.1    Lee, C.H.2    Hwang, I.K.3    Won, M.H.4    Seong, J.K.5    Yoon, Y.S.6    Lee, H.S.7    Lee, I.S.8
  • 50
    • 44549083195 scopus 로고    scopus 로고
    • Comparison of ionized calcium-binding adapter molecule 1 immunoreactivity of the hippocampal dentate gyrus and CA1 region in adult and aged dogs
    • Hwang IK, Lee CH, Li H, Yoo KY, Choi JH, Kim DW, Suh HW, Won MH. Comparison of ionized calcium-binding adapter molecule 1 immunoreactivity of the hippocampal dentate gyrus and CA1 region in adult and aged dogs. Neurochem Res 2008; 33: 1309-1315
    • (2008) Neurochem Res , vol.33 , pp. 1309-1315
    • Hwang, I.K.1    Lee, C.H.2    Li, H.3    Yoo, K.Y.4    Choi, J.H.5    Kim, D.W.6    Suh, H.W.7    Won, M.H.8
  • 52
    • 0032190996 scopus 로고    scopus 로고
    • Glial reaction in aging and Alzheimer's disease
    • Unger JW. Glial reaction in aging and Alzheimer's disease. Microsc Res Tech 1998; 43: 24-28
    • (1998) Microsc Res Tech , vol.43 , pp. 24-28
    • Unger, J.W.1
  • 54
    • 0038198881 scopus 로고    scopus 로고
    • Neurons, glia, and plasticity in normal brain aging
    • Finch CE. Neurons, glia, and plasticity in normal brain aging. Neurobiol Aging 2003; 24 (Suppl. 1): S123-127; discussion S131
    • (2003) Neurobiol Aging , vol.24 , Issue.SUPPL. 1
    • Finch, C.E.1
  • 55
    • 0042360512 scopus 로고    scopus 로고
    • Analysis of glial acidic fibrillary protein in the human entorhinal cortex during aging and in Alzheimer's disease
    • Porchet R, Probst A, Bouras C, Draberova E, Draber P, Riederer BM. Analysis of glial acidic fibrillary protein in the human entorhinal cortex during aging and in Alzheimer's disease. Proteomics 2003; 3: 1476-1485
    • (2003) Proteomics , vol.3 , pp. 1476-1485
    • Porchet, R.1    Probst, A.2    Bouras, C.3    Draberova, E.4    Draber, P.5    Riederer, B.M.6
  • 56
    • 7944223409 scopus 로고    scopus 로고
    • Astrocyte intermediate filaments in CNS pathologies and regeneration
    • Pekny M, Pekna M. Astrocyte intermediate filaments in CNS pathologies and regeneration. J Pathol 2004; 204: 428-437
    • (2004) J Pathol , vol.204 , pp. 428-437
    • Pekny, M.1    Pekna, M.2
  • 57
    • 0034305621 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)
    • Eng LF, Ghirnikar RS, Lee YL. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem Res 2000; 25: 1439-1451
    • (2000) Neurochem Res , vol.25 , pp. 1439-1451
    • Eng, L.F.1    Ghirnikar, R.S.2    Lee, Y.L.3
  • 58
    • 37049017788 scopus 로고    scopus 로고
    • Modulation by astrocytes of microglial cell-mediated neuroinflammation: effect on the activation of microglial signaling pathways
    • Tichauer J, Saud K, von Bernhardi R. Modulation by astrocytes of microglial cell-mediated neuroinflammation: effect on the activation of microglial signaling pathways. Neuroimmunomodulation 2007; 14: 168-174
    • (2007) Neuroimmunomodulation , vol.14 , pp. 168-174
    • Tichauer, J.1    von Saud, K.2    Bernhardi, R.3
  • 59
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott NJ, Ronnback L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006; 7: 41-53
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 60
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008; 57: 178-201
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1
  • 62
    • 0032476641 scopus 로고    scopus 로고
    • Astrocyte expression of monocyte chemoattractant protein-1 is differentially regulated by transforming growth factor beta
    • Weiss JM, Berman JW. Astrocyte expression of monocyte chemoattractant protein-1 is differentially regulated by transforming growth factor beta. J Neuroimmunol 1998; 91: 190-197
    • (1998) J Neuroimmunol , vol.91 , pp. 190-197
    • Weiss, J.M.1    Berman, J.W.2
  • 63
    • 77957689347 scopus 로고    scopus 로고
    • TGFbeta signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke
    • Doyle KP, Cekanaviciute E, Mamer LE, Buckwalter MS. TGFbeta signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke. J Neuroinflammation 2010; 7: 62
    • (2010) J Neuroinflammation , vol.7 , pp. 62
    • Doyle, K.P.1    Cekanaviciute, E.2    Mamer, L.E.3    Buckwalter, M.S.4
  • 65
    • 18344363014 scopus 로고    scopus 로고
    • Improved psychomotor performance in aged mice fed diet high in antioxidants is associated with reduced ex vivo brain interleukin-6 production
    • Richwine AF, Godbout JP, Berg BM, Chen J, Escobar J, Millard DK, Johnson RW. Improved psychomotor performance in aged mice fed diet high in antioxidants is associated with reduced ex vivo brain interleukin-6 production. Brain Behav Immun 2005; 19: 512-520
    • (2005) Brain Behav Immun , vol.19 , pp. 512-520
    • Richwine, A.F.1    Godbout, J.P.2    Berg, B.M.3    Chen, J.4    Escobar, J.5    Millard, D.K.6    Johnson, R.W.7
  • 66
    • 51649126499 scopus 로고    scopus 로고
    • Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice
    • Hayashi Y, Yoshida M, Yamato M, Ide T, Wu Z, Ochi-Shindou M, Kanki T, Kang D, Sunagawa K, Tsutsui H, Nakanishi H. Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice. J Neurosci 2008; 28: 8624-8634
    • (2008) J Neurosci , vol.28 , pp. 8624-8634
    • Hayashi, Y.1    Yoshida, M.2    Yamato, M.3    Ide, T.4    Wu, Z.5    Ochi-Shindou, M.6    Kanki, T.7    Kang, D.8    Sunagawa, K.9    Tsutsui, H.10    Nakanishi, H.11
  • 67
    • 49649086873 scopus 로고    scopus 로고
    • Neuroinflammation and cognitive function in aged mice following minor surgery
    • Rosczyk HA, Sparkman NL, Johnson RW. Neuroinflammation and cognitive function in aged mice following minor surgery. Exp Gerontol 2008; 43: 840-846
    • (2008) Exp Gerontol , vol.43 , pp. 840-846
    • Rosczyk, H.A.1    Sparkman, N.L.2    Johnson, R.W.3
  • 68
    • 77958133125 scopus 로고    scopus 로고
    • Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice
    • Jang S, Dilger RN, Johnson RW. Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J Nutr 2010; 140: 1892-1898
    • (2010) J Nutr , vol.140 , pp. 1892-1898
    • Jang, S.1    Dilger, R.N.2    Johnson, R.W.3
  • 71
    • 25444533023 scopus 로고    scopus 로고
    • Exercise enhances learning and hippocampal neurogenesis in aged mice
    • van Praag H, Shubert T, Zhao C, Gage FH. Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 2005; 25: 8680-8685
    • (2005) J Neurosci , vol.25 , pp. 8680-8685
    • van Praag, H.1    Shubert, T.2    Zhao, C.3    Gage, F.H.4
  • 73
    • 0027332670 scopus 로고
    • Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus
    • Bellinger FP, Madamba S, Siggins GR. Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus. Brain Res 1993; 628: 227-234
    • (1993) Brain Res , vol.628 , pp. 227-234
    • Bellinger, F.P.1    Madamba, S.2    Siggins, G.R.3
  • 74
    • 0029671172 scopus 로고    scopus 로고
    • Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro
    • Cunningham AJ, Murray CA, O'Neill LA, Lynch MA, O'Connor JJ. Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro. Neurosci Lett 1996; 203: 17-20
    • (1996) Neurosci Lett , vol.203 , pp. 17-20
    • Cunningham, A.J.1    Murray, C.A.2    O'Neill, L.A.3    Lynch, M.A.4    O'Connor, J.J.5
  • 75
    • 0035824540 scopus 로고    scopus 로고
    • The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibitory effect of IL-1 beta on long term potentiation. A role for JNK
    • Kelly A, Lynch A, Vereker E, Nolan Y, Queenan P, Whittaker E, O'Neill LA, Lynch MA. The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibitory effect of IL-1 beta on long term potentiation. A role for JNK. J Biol Chem 2001; 276: 45564-45572
    • (2001) J Biol Chem , vol.276 , pp. 45564-45572
    • Kelly, A.1    Lynch, A.2    Vereker, E.3    Nolan, Y.4    Queenan, P.5    Whittaker, E.6    O'Neill, L.A.7    Lynch, M.A.8
  • 76
    • 0034666435 scopus 로고    scopus 로고
    • The inhibitory effect of interleukin-1beta on long-term potentiation is coupled with increased activity of stress-activated protein kinases
    • Vereker E, O'Donnell E, Lynch MA. The inhibitory effect of interleukin-1beta on long-term potentiation is coupled with increased activity of stress-activated protein kinases. J Neurosci 2000; 20: 6811-6819
    • (2000) J Neurosci , vol.20 , pp. 6811-6819
    • Vereker, E.1    O'Donnell, E.2    Lynch, M.A.3
  • 79
    • 24144483438 scopus 로고    scopus 로고
    • BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis
    • Bramham CR, Messaoudi E. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol 2005; 76: 99-125
    • (2005) Prog Neurobiol , vol.76 , pp. 99-125
    • Bramham, C.R.1    Messaoudi, E.2
  • 80
    • 23044488902 scopus 로고    scopus 로고
    • The yin and yang of neurotrophin action
    • Lu B, Pang PT, Woo NH. The yin and yang of neurotrophin action. Nat Rev Neurosci 2005; 6: 603-614
    • (2005) Nat Rev Neurosci , vol.6 , pp. 603-614
    • Lu, B.1    Pang, P.T.2    Woo, N.H.3
  • 81
    • 0036742611 scopus 로고    scopus 로고
    • From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning
    • Tyler WJ, Alonso M, Bramham CR, Pozzo-Miller LD. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learn Mem 2002; 9: 224-237
    • (2002) Learn Mem , vol.9 , pp. 224-237
    • Tyler, W.J.1    Alonso, M.2    Bramham, C.R.3    Pozzo-Miller, L.D.4
  • 83
    • 79952772473 scopus 로고    scopus 로고
    • Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes
    • Cortese GP, Barrientos RM, Maier SF, Patterson SL. Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes. J Neurosci 2011; 31: 4274-4279
    • (2011) J Neurosci , vol.31 , pp. 4274-4279
    • Cortese, G.P.1    Barrientos, R.M.2    Maier, S.F.3    Patterson, S.L.4
  • 86
    • 69249122509 scopus 로고    scopus 로고
    • Exercise increases neural stem cell number in a growth hormone-dependent manner, augmenting the regenerative response in aged mice
    • Blackmore DG, Golmohammadi MG, Large B, Waters MJ, Rietze RL. Exercise increases neural stem cell number in a growth hormone-dependent manner, augmenting the regenerative response in aged mice. Stem Cells 2009; 27: 2044-2052
    • (2009) Stem Cells , vol.27 , pp. 2044-2052
    • Blackmore, D.G.1    Golmohammadi, M.G.2    Large, B.3    Waters, M.J.4    Rietze, R.L.5
  • 89
    • 84860666072 scopus 로고    scopus 로고
    • Microglia modulate hippocampal neural precursor activity in response to exercise and aging
    • Vukovic J, Colditz MJ, Blackmore DG, Ruitenberg MJ, Bartlett PF. Microglia modulate hippocampal neural precursor activity in response to exercise and aging. J Neurosci 2012; 32: 6435-6443
    • (2012) J Neurosci , vol.32 , pp. 6435-6443
    • Vukovic, J.1    Colditz, M.J.2    Blackmore, D.G.3    Ruitenberg, M.J.4    Bartlett, P.F.5
  • 90
    • 84861986137 scopus 로고    scopus 로고
    • Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice
    • Kohman RA, Deyoung EK, Bhattacharya TK, Peterson LN, Rhodes JS. Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice. Brain Behav Immun 2012; 26: 803-810
    • (2012) Brain Behav Immun , vol.26 , pp. 803-810
    • Kohman, R.A.1    Deyoung, E.K.2    Bhattacharya, T.K.3    Peterson, L.N.4    Rhodes, J.S.5
  • 91
    • 33746310890 scopus 로고    scopus 로고
    • Age and neuroinflammation: a lifetime of psychoneuroimmune consequences
    • Godbout JP, Johnson RW. Age and neuroinflammation: a lifetime of psychoneuroimmune consequences. Neurol Clin 2006; 24: 521-538
    • (2006) Neurol Clin , vol.24 , pp. 521-538
    • Godbout, J.P.1    Johnson, R.W.2
  • 92
    • 84856181466 scopus 로고    scopus 로고
    • Dysregulated neuronal-microglial cross-talk during aging, stress and inflammation
    • Jurgens HA, Johnson RW. Dysregulated neuronal-microglial cross-talk during aging, stress and inflammation. Exp Neurol 2012; 233: 40-48
    • (2012) Exp Neurol , vol.233 , pp. 40-48
    • Jurgens, H.A.1    Johnson, R.W.2
  • 93
    • 84860775990 scopus 로고    scopus 로고
    • Cognitive and behavioral consequences of impaired immunoregulation in aging
    • Corona AW, Fenn AM, Godbout JP. Cognitive and behavioral consequences of impaired immunoregulation in aging. J Neuroimmune Pharmacol 2012; 7: 7-23
    • (2012) J Neuroimmune Pharmacol , vol.7 , pp. 7-23
    • Corona, A.W.1    Fenn, A.M.2    Godbout, J.P.3
  • 95
    • 51449117700 scopus 로고    scopus 로고
    • Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide
    • Huang Y, Henry CJ, Dantzer R, Johnson RW, Godbout JP. Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide. Neurobiol Aging 2008; 29: 1744-1753
    • (2008) Neurobiol Aging , vol.29 , pp. 1744-1753
    • Huang, Y.1    Henry, C.J.2    Dantzer, R.3    Johnson, R.W.4    Godbout, J.P.5
  • 97
    • 84861970203 scopus 로고    scopus 로고
    • Interleukin-6 trans-signaling in the senescent mouse brain is involved in infection-related deficits in contextual fear conditioning
    • Burton MD, Johnson RW. Interleukin-6 trans-signaling in the senescent mouse brain is involved in infection-related deficits in contextual fear conditioning. Brain Behav Immun 2012; 26: 732-738
    • (2012) Brain Behav Immun , vol.26 , pp. 732-738
    • Burton, M.D.1    Johnson, R.W.2
  • 99
    • 0035800589 scopus 로고    scopus 로고
    • Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum
    • He Y, Appel S, Le W. Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum. Brain Res 2001; 909: 187-193
    • (2001) Brain Res , vol.909 , pp. 187-193
    • He, Y.1    Appel, S.2    Le, W.3
  • 100
    • 34447540331 scopus 로고    scopus 로고
    • Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII
    • Nikodemova M, Watters JJ, Jackson SJ, Yang SK, Duncan ID. Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII. J Biol Chem 2007; 282: 15208-15216
    • (2007) J Biol Chem , vol.282 , pp. 15208-15216
    • Nikodemova, M.1    Watters, J.J.2    Jackson, S.J.3    Yang, S.K.4    Duncan, I.D.5
  • 102
    • 81355132325 scopus 로고    scopus 로고
    • Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function
    • Njie EG, Boelen E, Stassen FR, Steinbusch HW, Borchelt DR, Streit WJ. Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function. Neurobiol Aging 2012; 33: 195 e191-112
    • (2012) Neurobiol Aging , vol.33
    • Njie, E.G.1    Boelen, E.2    Stassen, F.R.3    Steinbusch, H.W.4    Borchelt, D.R.5    Streit, W.J.6
  • 103
    • 78650994912 scopus 로고    scopus 로고
    • Protracted downregulation of CX(3)CR1 on microglia of aged mice after lipopolysaccharide challenge
    • Wynne AM, Henry CJ, Huang Y, Cleland A, Godbout JP. Protracted downregulation of CX(3)CR1 on microglia of aged mice after lipopolysaccharide challenge. Brain Behav Immun 2010; 24: 1190-1201
    • (2010) Brain Behav Immun , vol.24 , pp. 1190-1201
    • Wynne, A.M.1    Henry, C.J.2    Huang, Y.3    Cleland, A.4    Godbout, J.P.5
  • 104
    • 46249110091 scopus 로고    scopus 로고
    • Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice
    • Buchanan JB, Sparkman NL, Chen J, Johnson RW. Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice. Psychoneuroendocrinology 2008; 33: 755-765
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 755-765
    • Buchanan, J.B.1    Sparkman, N.L.2    Chen, J.3    Johnson, R.W.4
  • 105
    • 70349807619 scopus 로고    scopus 로고
    • Immune activation in brain aging and neurodegeneration: too much or too little?
    • Lucin KM, Wyss-Coray T. Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 2009; 64: 110-122
    • (2009) Neuron , vol.64 , pp. 110-122
    • Lucin, K.M.1    Wyss-Coray, T.2
  • 106
    • 0027374785 scopus 로고
    • Alzheimer's disease and Creutzfeldt-Jakob disease: overlap of pathogenic mechanisms
    • DeArmond SJ. Alzheimer's disease and Creutzfeldt-Jakob disease: overlap of pathogenic mechanisms. Curr Opin Neurol 1993; 6: 872-881
    • (1993) Curr Opin Neurol , vol.6 , pp. 872-881
    • DeArmond, S.J.1
  • 107
    • 0027248501 scopus 로고
    • Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses
    • Price DL, Borchelt DR, Sisodia SS. Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses. Proc Natl Acad Sci U S A 1993; 90: 6381-6384
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6381-6384
    • Price, D.L.1    Borchelt, D.R.2    Sisodia, S.S.3
  • 108
    • 0037264120 scopus 로고    scopus 로고
    • Unfolding the role of protein misfolding in neurodegenerative diseases
    • Soto C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nat Rev Neurosci 2003; 4: 49-60
    • (2003) Nat Rev Neurosci , vol.4 , pp. 49-60
    • Soto, C.1
  • 109
    • 27144470284 scopus 로고    scopus 로고
    • Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration
    • Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci 2005; 25: 9275-9284
    • (2005) J Neurosci , vol.25 , pp. 9275-9284
    • Cunningham, C.1    Wilcockson, D.C.2    Campion, S.3    Lunnon, K.4    Perry, V.H.5
  • 110
    • 0035704245 scopus 로고    scopus 로고
    • Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Sly LM, Krzesicki RF, Brashler JR, Buhl AE, McKinley DD, Carter DB, Chin JE. Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease. Brain Res Bull 2001; 56: 581-588
    • (2001) Brain Res Bull , vol.56 , pp. 581-588
    • Sly, L.M.1    Krzesicki, R.F.2    Brashler, J.R.3    Buhl, A.E.4    McKinley, D.D.5    Carter, D.B.6    Chin, J.E.7
  • 111
    • 0036362861 scopus 로고    scopus 로고
    • Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain
    • Lee J, Chan SL, Mattson MP. Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain. Neuromolecular Med 2002; 2: 29-45
    • (2002) Neuromolecular Med , vol.2 , pp. 29-45
    • Lee, J.1    Chan, S.L.2    Mattson, M.P.3
  • 113
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    • Hickman SE, Allison EK, El Khoury J. Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci 2008; 28: 8354-8360
    • (2008) J Neurosci , vol.28 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 114
    • 77957316313 scopus 로고    scopus 로고
    • CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models
    • Lee S, Varvel NH, Konerth ME, Xu G, Cardona AE, Ransohoff RM, Lamb BT. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am J Pathol 2010; 177: 2549-2562
    • (2010) Am J Pathol , vol.177 , pp. 2549-2562
    • Lee, S.1    Varvel, N.H.2    Konerth, M.E.3    Xu, G.4    Cardona, A.E.5    Ransohoff, R.M.6    Lamb, B.T.7
  • 115
    • 33644910475 scopus 로고    scopus 로고
    • Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination
    • Zhao C, Li WW, Franklin RJ. Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination. Neurobiol Aging 2006; 27: 1298-1307
    • (2006) Neurobiol Aging , vol.27 , pp. 1298-1307
    • Zhao, C.1    Li, W.W.2    Franklin, R.J.3
  • 117
    • 63249089707 scopus 로고    scopus 로고
    • Characterization of the sickness response in young and aging rats following E. coli infection
    • Barrientos RM, Watkins LR, Rudy JW, Maier SF. Characterization of the sickness response in young and aging rats following E. coli infection. Brain Behav Immun 2009; 23: 450-454
    • (2009) Brain Behav Immun , vol.23 , pp. 450-454
    • Barrientos, R.M.1    Watkins, L.R.2    Rudy, J.W.3    Maier, S.F.4
  • 118
    • 61649120189 scopus 로고    scopus 로고
    • Central inhibition of interleukin-1beta ameliorates sickness behavior in aged mice
    • Abraham J, Johnson RW. Central inhibition of interleukin-1beta ameliorates sickness behavior in aged mice. Brain Behav Immun 2009; 23: 396-401
    • (2009) Brain Behav Immun , vol.23 , pp. 396-401
    • Abraham, J.1    Johnson, R.W.2
  • 119
    • 64649100658 scopus 로고    scopus 로고
    • Age and neuroinflammation: a lifetime of psychoneuroimmune consequences
    • Godbout JP, Johnson RW. Age and neuroinflammation: a lifetime of psychoneuroimmune consequences. Immunol Allergy Clin North Am 2009; 29: 321-337
    • (2009) Immunol Allergy Clin North Am , vol.29 , pp. 321-337
    • Godbout, J.P.1    Johnson, R.W.2
  • 120
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: when the immune system subjugates the brain
    • Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008; 9: 46-56
    • (2008) Nat Rev Neurosci , vol.9 , pp. 46-56
    • Dantzer, R.1    O'Connor, J.C.2    Freund, G.G.3    Johnson, R.W.4    Kelley, K.W.5
  • 121
    • 84856111463 scopus 로고    scopus 로고
    • Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior
    • Haroon E, Raison CL, Miller AH. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 2012; 37: 137-162
    • (2012) Neuropsychopharmacology , vol.37 , pp. 137-162
    • Haroon, E.1    Raison, C.L.2    Miller, A.H.3
  • 124
    • 1642451984 scopus 로고    scopus 로고
    • Interleukin-6 in the aging brain
    • Godbout JP, Johnson RW. Interleukin-6 in the aging brain. J Neuroimmunol 2004; 147: 141-144
    • (2004) J Neuroimmunol , vol.147 , pp. 141-144
    • Godbout, J.P.1    Johnson, R.W.2
  • 126
    • 0142247472 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist
    • Barrientos RM, Sprunger DB, Campeau S, Higgins EA, Watkins LR, Rudy JW, Maier SF. Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist. Neuroscience 2003; 121: 847-853
    • (2003) Neuroscience , vol.121 , pp. 847-853
    • Barrientos, R.M.1    Sprunger, D.B.2    Campeau, S.3    Higgins, E.A.4    Watkins, L.R.5    Rudy, J.W.6    Maier, S.F.7
  • 127
    • 4444338123 scopus 로고    scopus 로고
    • BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration
    • Barrientos RM, Sprunger DB, Campeau S, Watkins LR, Rudy JW, Maier SF. BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration. J Neuroimmunol 2004; 155: 119-126
    • (2004) J Neuroimmunol , vol.155 , pp. 119-126
    • Barrientos, R.M.1    Sprunger, D.B.2    Campeau, S.3    Watkins, L.R.4    Rudy, J.W.5    Maier, S.F.6
  • 128
    • 38649119160 scopus 로고    scopus 로고
    • Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system
    • Chen J, Buchanan JB, Sparkman NL, Godbout JP, Freund GG, Johnson RW. Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav Immun 2008; 22: 301-311
    • (2008) Brain Behav Immun , vol.22 , pp. 301-311
    • Chen, J.1    Buchanan, J.B.2    Sparkman, N.L.3    Godbout, J.P.4    Freund, G.G.5    Johnson, R.W.6
  • 130
    • 77649208936 scopus 로고    scopus 로고
    • Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice
    • Abraham J, Johnson RW. Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. Rejuvenation Res 2009; 12: 445-453
    • (2009) Rejuvenation Res , vol.12 , pp. 445-453
    • Abraham, J.1    Johnson, R.W.2
  • 131
    • 77953218064 scopus 로고    scopus 로고
    • Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1
    • Chapman TR, Barrientos RM, Ahrendsen JT, Maier SF, Patterson SL. Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1. J Neurosci 2010; 30: 7598-7603
    • (2010) J Neurosci , vol.30 , pp. 7598-7603
    • Chapman, T.R.1    Barrientos, R.M.2    Ahrendsen, J.T.3    Maier, S.F.4    Patterson, S.L.5
  • 134
    • 84861989218 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced interleukin (IL)-4 receptor-alpha expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice
    • Fenn AM, Henry CJ, Huang Y, Dugan A, Godbout JP. Lipopolysaccharide-induced interleukin (IL)-4 receptor-alpha expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice. Brain Behav Immun 2012; 26: 766-777
    • (2012) Brain Behav Immun , vol.26 , pp. 766-777
    • Fenn, A.M.1    Henry, C.J.2    Huang, Y.3    Dugan, A.4    Godbout, J.P.5
  • 135
    • 0344013136 scopus 로고    scopus 로고
    • TGFbeta directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes
    • Paglinawan R, Malipiero U, Schlapbach R, Frei K, Reith W, Fontana A. TGFbeta directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes. Glia 2003; 44: 219-231
    • (2003) Glia , vol.44 , pp. 219-231
    • Paglinawan, R.1    Malipiero, U.2    Schlapbach, R.3    Frei, K.4    Reith, W.5    Fontana, A.6
  • 137
    • 34247346030 scopus 로고    scopus 로고
    • IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro
    • Lyons A, Griffin RJ, Costelloe CE, Clarke RM, Lynch MA. IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro. J Neurochem 2007; 101: 771-781
    • (2007) J Neurochem , vol.101 , pp. 771-781
    • Lyons, A.1    Griffin, R.J.2    Costelloe, C.E.3    Clarke, R.M.4    Lynch, M.A.5
  • 138
    • 79551685206 scopus 로고    scopus 로고
    • Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice
    • Derecki NC, Quinnies KM, Kipnis J. Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice. Brain Behav Immun 2011; 25: 379-385
    • (2011) Brain Behav Immun , vol.25 , pp. 379-385
    • Derecki, N.C.1    Quinnies, K.M.2    Kipnis, J.3
  • 139
    • 70350558453 scopus 로고    scopus 로고
    • Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    • Kigerl KA, Gensel JC, Ankeny DP, Alexander JK, Donnelly DJ, Popovich PG. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci 2009; 29: 13435-13444
    • (2009) J Neurosci , vol.29 , pp. 13435-13444
    • Kigerl, K.A.1    Gensel, J.C.2    Ankeny, D.P.3    Alexander, J.K.4    Donnelly, D.J.5    Popovich, P.G.6
  • 140
    • 0037821637 scopus 로고    scopus 로고
    • Production and neuroprotective functions of fractalkine in the central nervous system
    • Mizuno T, Kawanokuchi J, Numata K, Suzumura A. Production and neuroprotective functions of fractalkine in the central nervous system. Brain Res 2003; 979: 65-70
    • (2003) Brain Res , vol.979 , pp. 65-70
    • Mizuno, T.1    Kawanokuchi, J.2    Numata, K.3    Suzumura, A.4
  • 141
    • 0034652697 scopus 로고    scopus 로고
    • Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation
    • Zujovic V, Benavides J, Vige X, Carter C, Taupin V. Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation. Glia 2000; 29: 305-315
    • (2000) Glia , vol.29 , pp. 305-315
    • Zujovic, V.1    Benavides, J.2    Vige, X.3    Carter, C.4    Taupin, V.5
  • 142
    • 68949200462 scopus 로고    scopus 로고
    • Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro
    • Lyons A, Lynch AM, Downer EJ, Hanley R, O'Sullivan JB, Smith A, Lynch MA. Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro. J Neurochem 2009; 110: 1547-1556
    • (2009) J Neurochem , vol.110 , pp. 1547-1556
    • Lyons, A.1    Lynch, A.M.2    Downer, E.J.3    Hanley, R.4    O'Sullivan, J.B.5    Smith, A.6    Lynch, M.A.7
  • 145
    • 84878145540 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX3CR1)-deficient mice
    • doi: 10.1016/j.bbi.2012.08.008
    • Corona AW, Norden DM, Skendelas JP, Huang Y, O'Connor JC, Lawson M, Dantzer R, Kelley KW, Godbout JP. Indoleamine 2, 3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX3CR1)-deficient mice. Brain Behav Immun 2012. doi: 10.1016/j.bbi.2012.08.008
    • (2012) Brain Behav Immun
    • Corona, A.W.1    Norden, D.M.2    Skendelas, J.P.3    Huang, Y.4    O'Connor, J.C.5    Lawson, M.6    Dantzer, R.7    Kelley, K.W.8    Godbout, J.P.9
  • 148
    • 34547680192 scopus 로고    scopus 로고
    • CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4
    • Lyons A, Downer EJ, Crotty S, Nolan YM, Mills KH, Lynch MA. CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4. J Neurosci 2007; 27: 8309-8313
    • (2007) J Neurosci , vol.27 , pp. 8309-8313
    • Lyons, A.1    Downer, E.J.2    Crotty, S.3    Nolan, Y.M.4    Mills, K.H.5    Lynch, M.A.6
  • 149
    • 0036841128 scopus 로고    scopus 로고
    • Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis
    • Broderick C, Hoek RM, Forrester JV, Liversidge J, Sedgwick JD, Dick AD. Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am J Pathol 2002; 161: 1669-1677
    • (2002) Am J Pathol , vol.161 , pp. 1669-1677
    • Broderick, C.1    Hoek, R.M.2    Forrester, J.V.3    Liversidge, J.4    Sedgwick, J.D.5    Dick, A.D.6
  • 150
    • 69949147155 scopus 로고    scopus 로고
    • Systemic lipopolysaccharide (LPS)-induced microglial activation results in different temporal reduction of CD200 and CD200 receptor gene expression in the brain
    • Masocha W. Systemic lipopolysaccharide (LPS)-induced microglial activation results in different temporal reduction of CD200 and CD200 receptor gene expression in the brain. J Neuroimmunol 2009; 214: 78-82
    • (2009) J Neuroimmunol , vol.214 , pp. 78-82
    • Masocha, W.1
  • 151
    • 84861993323 scopus 로고    scopus 로고
    • CD200 fusion protein decreases microglial activation in the hippocampus of aged rats
    • Cox FF, Carney D, Miller AM, Lynch MA. CD200 fusion protein decreases microglial activation in the hippocampus of aged rats. Brain Behav Immun 2012; 26: 789-796
    • (2012) Brain Behav Immun , vol.26 , pp. 789-796
    • Cox, F.F.1    Carney, D.2    Miller, A.M.3    Lynch, M.A.4
  • 153
    • 84861988786 scopus 로고    scopus 로고
    • Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL
    • Ojo B, Rezaie P, Gabbott PL, Davies H, Colyer F, Cowley TR, Lynch M, Stewart MG. Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL. Brain Behav Immun 2012; 26: 778-788
    • (2012) Brain Behav Immun , vol.26 , pp. 778-788
    • Ojo, B.1    Rezaie, P.2    Gabbott, P.L.3    Davies, H.4    Colyer, F.5    Cowley, T.R.6    Lynch, M.7    Stewart, M.G.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.