메뉴 건너뛰기




Volumn 22, Issue 3, 2016, Pages 238-249

Synaptic plasticity and depression: New insights from stress and rapid-acting antidepressants

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CYTOKINE; GLUCOCORTICOID; INFLAMMASOME; NEUROTROPHIC FACTOR; AMINO ACID RECEPTOR BLOCKING AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; KETAMINE; SEROTONIN UPTAKE INHIBITOR;

EID: 84978745497     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4050     Document Type: Review
Times cited : (1148)

References (195)
  • 1
    • 84887259083 scopus 로고    scopus 로고
    • Global burden of disease attributable to mental and substance use disorders: Findings from the global burden of disease study 2010
    • Whiteford, H.A. et al. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet 382, 1575-1586 (2013).
    • (2013) Lancet , vol.382 , pp. 1575-1586
    • Whiteford, H.A.1
  • 2
    • 0037831023 scopus 로고    scopus 로고
    • The epidemiology of major depressive disorder: Results from the national comorbidity survey replication (NCS-R)
    • Kessler, R.C. et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). J. Am. Med. Assoc. 289, 3095-3105 (2003).
    • (2003) J. Am. Med. Assoc. , vol.289 , pp. 3095-3105
    • Kessler, R.C.1
  • 3
    • 30044433660 scopus 로고    scopus 로고
    • Evaluation of outcomes with citalopram for depression using measurement-based care in STAR∗D: Implications for clinical practice
    • Trivedi, M.H. et al. STAR∗D Study Team. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR∗D: implications for clinical practice. Am. J. Psychiatry 163, 28-40 (2006).
    • (2006) Am. J. Psychiatry , vol.163 , pp. 28-40
    • Trivedi, M.H.1
  • 4
    • 84928023204 scopus 로고    scopus 로고
    • Mortality in mental disorders and global disease burden implications: A systematic review and meta-analysis
    • Walker, E.R., McGee, R.E. & Druss, B.G. Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psychiatry 72, 334-341 (2015).
    • (2015) JAMA Psychiatry , vol.72 , pp. 334-341
    • Walker, E.R.1    McGee, R.E.2    Druss, B.G.3
  • 5
    • 85047681066 scopus 로고    scopus 로고
    • What did STAR∗D teach us? Results from a large-scale, practical, clinical trial for patients with depression
    • Gaynes, B.N. et al. What did STAR∗D teach us? Results from a large-scale, practical, clinical trial for patients with depression. Psychiatr. Serv. 60, 1439-1445 (2009).
    • (2009) Psychiatr. Serv. , vol.60 , pp. 1439-1445
    • Gaynes, B.N.1
  • 7
    • 54149102607 scopus 로고    scopus 로고
    • Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder
    • MacQueen, G.M., Yucel, K., Taylor, V.H., Macdonald, K. & Joffe, R. Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder. Biol. Psychiatry 64, 880-883 (2008).
    • (2008) Biol. Psychiatry , vol.64 , pp. 880-883
    • MacQueen, G.M.1    Yucel, K.2    Taylor, V.H.3    Macdonald, K.4    Joffe, R.5
  • 8
    • 64549126898 scopus 로고    scopus 로고
    • Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide
    • Savitz, J. & Drevets, W.C. Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide. Neurosci. Biobehav. Rev. 33, 699-771 (2009).
    • (2009) Neurosci. Biobehav. Rev. , vol.33 , pp. 699-771
    • Savitz, J.1    Drevets, W.C.2
  • 9
    • 84867198044 scopus 로고    scopus 로고
    • Decreased expression of synapse-related genes and loss of synapses in major depressive disorder
    • Kang, H.J. et al. Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Nat. Med. 18, 1413-1417 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1413-1417
    • Kang, H.J.1
  • 10
    • 84867227874 scopus 로고    scopus 로고
    • Synaptic dysfunction in depression: Potential therapeutic targets
    • Duman, R.S. & Aghajanian, G.K. Synaptic dysfunction in depression: potential therapeutic targets. Science 338, 68-72 (2012).
    • (2012) Science , vol.338 , pp. 68-72
    • Duman, R.S.1    Aghajanian, G.K.2
  • 11
    • 80054100023 scopus 로고    scopus 로고
    • Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress
    • McEwen, B.S., Eiland, L., Hunter, R.G. & Miller, M.M. Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress. Neuropharmacology 62, 3-12 (2012).
    • (2012) Neuropharmacology , vol.62 , pp. 3-12
    • McEwen, B.S.1    Eiland, L.2    Hunter, R.G.3    Miller, M.M.4
  • 12
    • 84858702953 scopus 로고    scopus 로고
    • The aging cortical synapse: Hallmarks and implications for cognitive decline
    • Morrison, J.H. & Baxter, M.G. The aging cortical synapse: hallmarks and implications for cognitive decline. Nat. Rev. Neurosci. 13, 240-250 (2012).
    • (2012) Nat. Rev. Neurosci. , vol.13 , pp. 240-250
    • Morrison, J.H.1    Baxter, M.G.2
  • 13
    • 69249100460 scopus 로고    scopus 로고
    • Experience-dependent structural synaptic plasticity in the mammalian brain
    • Holtmaat, A. & Svoboda, K. Experience-dependent structural synaptic plasticity in the mammalian brain. Nat. Rev. Neurosci. 10, 647-658 (2009).
    • (2009) Nat. Rev. Neurosci. , vol.10 , pp. 647-658
    • Holtmaat, A.1    Svoboda, K.2
  • 14
    • 59649114125 scopus 로고    scopus 로고
    • Synaptic AMPA receptor plasticity and behavior
    • Kessels, H.W. & Malinow, R. Synaptic AMPA receptor plasticity and behavior. Neuron 61, 340-350 (2009).
    • (2009) Neuron , vol.61 , pp. 340-350
    • Kessels, H.W.1    Malinow, R.2
  • 16
    • 42949123365 scopus 로고    scopus 로고
    • Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
    • Sanacora, G., Zarate, C.A., Krystal, J.H. & Manji, H.K. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nat. Rev. Drug Discov. 7, 426-437 (2008).
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 426-437
    • Sanacora, G.1    Zarate, C.A.2    Krystal, J.H.3    Manji, H.K.4
  • 17
    • 84155160658 scopus 로고    scopus 로고
    • The stressed synapse: The impact of stress and glucocorticoids on glutamate transmission
    • Popoli, M., Yan, Z., McEwen, B.S. & Sanacora, G. The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nat. Rev. Neurosci. 13, 22-37 (2012).
    • (2012) Nat. Rev. Neurosci. , vol.13 , pp. 22-37
    • Popoli, M.1    Yan, Z.2    McEwen, B.S.3    Sanacora, G.4
  • 18
    • 84869096094 scopus 로고    scopus 로고
    • Epigenetics of the depressed brain: Role of histone acetylation and methylation
    • Sun, H., Kennedy, P.J. & Nestler, E.J. Epigenetics of the depressed brain: role of histone acetylation and methylation. Neuropsychopharmacology 38, 124-137 (2013).
    • (2013) Neuropsychopharmacology , vol.38 , pp. 124-137
    • Sun, H.1    Kennedy, P.J.2    Nestler, E.J.3
  • 19
    • 84911422591 scopus 로고    scopus 로고
    • Epigenetic alterations in depression and antidepressant treatment
    • Menke, A. & Binder, E.B. Epigenetic alterations in depression and antidepressant treatment. Dialogues Clin. Neurosci. 16, 395-404 (2014).
    • (2014) Dialogues Clin. Neurosci. , vol.16 , pp. 395-404
    • Menke, A.1    Binder, E.B.2
  • 20
    • 3342989681 scopus 로고    scopus 로고
    • Epigenetic programming by maternal behavior
    • Weaver, I.C. et al. Epigenetic programming by maternal behavior. Nat. Neurosci. 7, 847-854 (2004).
    • (2004) Nat. Neurosci. , vol.7 , pp. 847-854
    • Weaver, I.C.1
  • 21
    • 54049133277 scopus 로고    scopus 로고
    • The molecular neurobiology of depression
    • Krishnan, V. & Nestler, E.J. The molecular neurobiology of depression. Nature 455, 894-902 (2008).
    • (2008) Nature , vol.455 , pp. 894-902
    • Krishnan, V.1    Nestler, E.J.2
  • 22
    • 0035034203 scopus 로고    scopus 로고
    • The cellular neurobiology of depression
    • Manji, H.K., Drevets, W.C. & Charney, D.S. The cellular neurobiology of depression. Nat. Med. 7, 541-547 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 541-547
    • Manji, H.K.1    Drevets, W.C.2    Charney, D.S.3
  • 23
    • 0036830579 scopus 로고    scopus 로고
    • Treatment of mood disorders
    • Nemeroff, C.B. & Owens, M.J. Treatment of mood disorders. Nat. Neurosci. 5, 1068-1070 (2002).
    • (2002) Nat. Neurosci. , vol.5 , pp. 1068-1070
    • Nemeroff, C.B.1    Owens, M.J.2
  • 24
    • 38349116509 scopus 로고    scopus 로고
    • Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy
    • Liu, R.J. & Aghajanian, G.K. Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy. Proc. Natl. Acad. Sci. USA 105, 359-364 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 359-364
    • Liu, R.J.1    Aghajanian, G.K.2
  • 25
    • 0029120661 scopus 로고
    • Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Involvement of glucocorticoid secretion and excitatory amino acid receptors
    • Magariños, A.M. & McEwen, B.S. Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors. Neuroscience 69, 89-98 (1995).
    • (1995) Neuroscience , vol.69 , pp. 89-98
    • Magariños, A.M.1    McEwen, B.S.2
  • 26
    • 0029014381 scopus 로고
    • Effect of acute stress on hippocampal glutamate levels and spectrin proteolysis in young and aged rats
    • Lowy, M.T., Wittenberg, L. & Yamamoto, B.K. Effect of acute stress on hippocampal glutamate levels and spectrin proteolysis in young and aged rats. J. Neurochem. 65, 268-274 (1995).
    • (1995) J. Neurochem. , vol.65 , pp. 268-274
    • Lowy, M.T.1    Wittenberg, L.2    Yamamoto, B.K.3
  • 27
    • 0030900732 scopus 로고    scopus 로고
    • Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex
    • Moghaddam, B., Adams, B., Verma, A. & Daly, D. Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J. Neurosci. 17, 2921-2927 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 2921-2927
    • Moghaddam, B.1    Adams, B.2    Verma, A.3    Daly, D.4
  • 28
    • 84869090771 scopus 로고    scopus 로고
    • Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans
    • Zhang, T.Y., Labonté, B., Wen, X.L., Turecki, G. & Meaney, M.J. Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans. Neuropsychopharmacology 38, 111-123 (2013).
    • (2013) Neuropsychopharmacology , vol.38 , pp. 111-123
    • Zhang, T.Y.1    Labonté, B.2    Wen, X.L.3    Turecki, G.4    Meaney, M.J.5
  • 29
    • 84927712813 scopus 로고    scopus 로고
    • Genetic determinants of depression: Recent findings and future directions
    • Dunn, E.C. et al. Genetic determinants of depression: recent findings and future directions. Harv. Rev. Psychiatry 23, 1-18 (2015).
    • (2015) Harv. Rev. Psychiatry , vol.23 , pp. 1-18
    • Dunn, E.C.1
  • 30
    • 84902997661 scopus 로고    scopus 로고
    • REDD1 is essential for stress-induced synaptic loss and depressive behavior
    • Ota, K.T. et al. REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nat. Med. 20, 531-535 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 531-535
    • Ota, K.T.1
  • 31
    • 77956917231 scopus 로고    scopus 로고
    • Synaptic versus extrasynaptic NMDA receptor signaling: Implications for neurodegenerative disorders
    • Hardingham, G.E. & Bading, H. Synaptic versus extrasynaptic NMDA receptor signaling: implications for neurodegenerative disorders. Nat. Rev. Neurosci. 11, 682-696 (2010).
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 682-696
    • Hardingham, G.E.1    Bading, H.2
  • 32
    • 77955637265 scopus 로고    scopus 로고
    • Serum and plasma BDNF levels in major depression: A replication study and meta-analyses
    • Bocchio-Chiavetto, L. et al. Serum and plasma BDNF levels in major depression: a replication study and meta-analyses. World J. Biol. Psychiatry 11, 763-773 (2010).
    • (2010) World J. Biol. Psychiatry , vol.11 , pp. 763-773
    • Bocchio-Chiavetto, L.1
  • 33
    • 33745208951 scopus 로고    scopus 로고
    • A neurotrophic model for stress-related mood disorders
    • Duman, R.S. & Monteggia, L.M. A neurotrophic model for stress-related mood disorders. Biol. Psychiatry 59, 1116-1127 (2006).
    • (2006) Biol. Psychiatry , vol.59 , pp. 1116-1127
    • Duman, R.S.1    Monteggia, L.M.2
  • 34
    • 70449714176 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor: Role in depression and suicide
    • Dwivedi, Y. Brain-derived neurotrophic factor: role in depression and suicide. Neuropsychiatr. Dis. Treat. 5, 433-449 (2009).
    • (2009) Neuropsychiatr. Dis. Treat. , vol.5 , pp. 433-449
    • Dwivedi, Y.1
  • 35
    • 33745214866 scopus 로고    scopus 로고
    • The fibroblast growth factor system and mood disorders
    • Turner, C.A., Akil, H., Watson, S.J. & Evans, S.J. The fibroblast growth factor system and mood disorders. Biol. Psychiatry 59, 1128-1135 (2006).
    • (2006) Biol. Psychiatry , vol.59 , pp. 1128-1135
    • Turner, C.A.1    Akil, H.2    Watson, S.J.3    Evans, S.J.4
  • 36
    • 67650473167 scopus 로고    scopus 로고
    • Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation
    • Jourdi, H. et al. Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation. J. Neurosci. 29, 8688-8697 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 8688-8697
    • Jourdi, H.1
  • 37
    • 33745014606 scopus 로고    scopus 로고
    • Hippocampal cell proliferation regulation by repeated stress and antidepressants
    • Chen, H., Pandey, G.N. & Dwivedi, Y. Hippocampal cell proliferation regulation by repeated stress and antidepressants. Neuroreport 17, 863-867 (2006).
    • (2006) Neuroreport , vol.17 , pp. 863-867
    • Chen, H.1    Pandey, G.N.2    Dwivedi, Y.3
  • 38
    • 84857083262 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor val66met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex
    • Liu, R. et al. Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biol. Psychiatry 71, 996-1005 (2012).
    • (2012) Biol. Psychiatry , vol.71 , pp. 996-1005
    • Liu, R.1
  • 39
    • 84884288609 scopus 로고    scopus 로고
    • GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine
    • Liu, R.J. et al. GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine. Neuropsychopharmacology 38, 2268-2277 (2013).
    • (2013) Neuropsychopharmacology , vol.38 , pp. 2268-2277
    • Liu, R.J.1
  • 40
    • 79951906240 scopus 로고    scopus 로고
    • Effect of brain-derived neurotrophic factor haploinsufficiency on stress-induced remodeling of hippocampal neurons
    • Magariños, A.M. et al. Effect of brain-derived neurotrophic factor haploinsufficiency on stress-induced remodeling of hippocampal neurons. Hippocampus 21, 253-264 (2011).
    • (2011) Hippocampus , vol.21 , pp. 253-264
    • Magariños, A.M.1
  • 41
    • 67349280482 scopus 로고    scopus 로고
    • Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior
    • Autry, A.E., Adachi, M., Cheng, P. & Monteggia, L.M. Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior. Biol. Psychiatry 66, 84-90 (2009).
    • (2009) Biol. Psychiatry , vol.66 , pp. 84-90
    • Autry, A.E.1    Adachi, M.2    Cheng, P.3    Monteggia, L.M.4
  • 42
    • 33847308098 scopus 로고    scopus 로고
    • A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment
    • Duman, C.H., Schlesinger, L., Kodama, M., Russell, D.S. & Duman, R.S. A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment. Biol. Psychiatry 61, 661-670 (2007b).
    • (2007) Biol. Psychiatry , vol.61 , pp. 661-670
    • Duman, C.H.1    Schlesinger, L.2    Kodama, M.3    Russell, D.S.4    Duman, R.S.5
  • 43
    • 67649327144 scopus 로고    scopus 로고
    • Val66Met polymorphism and early-life stress predict brain and arousal pathways to syndromal depression and anxiety
    • Val66Met polymorphism and early-life stress predict brain and arousal pathways to syndromal depression and anxiety. Mol. Psychiatry 14, 681-695 (2009).
    • (2009) Mol. Psychiatry , vol.14 , pp. 681-695
    • Gatt, J.M.1
  • 44
    • 33645337891 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children
    • Kaufman, J. et al. Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol. Psychiatry 59, 673-680 (2006).
    • (2006) Biol. Psychiatry , vol.59 , pp. 673-680
    • Kaufman, J.1
  • 45
    • 34548021027 scopus 로고    scopus 로고
    • Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders
    • Kim, J.M. et al. Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biol. Psychiatry 62, 423-428 (2007).
    • (2007) Biol. Psychiatry , vol.62 , pp. 423-428
    • Kim, J.M.1
  • 46
    • 75749114797 scopus 로고    scopus 로고
    • MTOR signaling: At the crossroads of plasticity, memory and disease
    • Hoeffer, C.A. & Klann, E. mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci. 33, 67-75 (2010).
    • (2010) Trends Neurosci. , vol.33 , pp. 67-75
    • Hoeffer, C.A.1    Klann, E.2
  • 47
    • 39849083186 scopus 로고    scopus 로고
    • BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?
    • Lu, Y., Christian, K. & Lu, B. BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol. Learn. Mem. 89, 312-323 (2008).
    • (2008) Neurobiol. Learn. Mem. , vol.89 , pp. 312-323
    • Lu, Y.1    Christian, K.2    Lu, B.3
  • 48
    • 70450196195 scopus 로고    scopus 로고
    • TrkB signaling pathways in LTP and learning
    • Minichiello, L. TrkB signaling pathways in LTP and learning. Nat. Rev. Neurosci. 10, 850-860 (2009).
    • (2009) Nat. Rev. Neurosci. , vol.10 , pp. 850-860
    • Minichiello, L.1
  • 49
    • 84912115519 scopus 로고    scopus 로고
    • MTOR and the health benefits of exercise
    • Watson, K. & Baar, K. mTOR and the health benefits of exercise. Semin. Cell Dev. Biol. 36, 130-139 (2014).
    • (2014) Semin. Cell Dev. Biol. , vol.36 , pp. 130-139
    • Watson, K.1    Baar, K.2
  • 50
    • 58149357209 scopus 로고    scopus 로고
    • Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression
    • Feyissa, A.M., Chandran, A., Stockmeier, C.A. & Karolewicz, B. Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 70-75 (2009).
    • (2009) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.33 , pp. 70-75
    • Feyissa, A.M.1    Chandran, A.2    Stockmeier, C.A.3    Karolewicz, B.4
  • 51
    • 79961129428 scopus 로고    scopus 로고
    • The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder
    • Jernigan, C.S. et al. The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 35, 1774-1779 (2011).
    • (2011) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.35 , pp. 1774-1779
    • Jernigan, C.S.1
  • 52
    • 77955909841 scopus 로고    scopus 로고
    • MTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
    • Li, N. et al. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 329, 959-964 (2010).
    • (2010) Science , vol.329 , pp. 959-964
    • Li, N.1
  • 53
    • 84886730107 scopus 로고    scopus 로고
    • Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis and antidepressant behavioral responses
    • Voleti, B. et al. Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis and antidepressant behavioral responses. Biol. Psychiatry 74, 742-749 (2013).
    • (2013) Biol. Psychiatry , vol.74 , pp. 742-749
    • Voleti, B.1
  • 54
    • 84868222901 scopus 로고    scopus 로고
    • Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress
    • Chandran, A. et al. Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress. Prog. Neuropsychopharmacol. Biol. Psychiatry 40, 240-245 (2013).
    • (2013) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.40 , pp. 240-245
    • Chandran, A.1
  • 55
    • 79953166373 scopus 로고    scopus 로고
    • Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
    • Li, N. et al. Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol. Psychiatry 69, 754-761 (2011).
    • (2011) Biol. Psychiatry , vol.69 , pp. 754-761
    • Li, N.1
  • 56
    • 0037573216 scopus 로고    scopus 로고
    • Endocrine factors in the etiology of postpartum depression
    • Bloch, M., Daly, R.C. & Rubinow, D.R. Endocrine factors in the etiology of postpartum depression. Compr. Psychiatry 44, 234-246 (2003).
    • (2003) Compr. Psychiatry , vol.44 , pp. 234-246
    • Bloch, M.1    Daly, R.C.2    Rubinow, D.R.3
  • 57
    • 79953752221 scopus 로고    scopus 로고
    • Hormones, heart disease and health: Individualized medicine versus throwing the baby out with the bathwater
    • Rubinow, D.R. & Girdler, S.S. Hormones, heart disease and health: individualized medicine versus throwing the baby out with the bathwater. Depress. Anxiety 28, E1-E15 (2011).
    • (2011) Depress. Anxiety , vol.28 , pp. E1-E15
    • Rubinow, D.R.1    Girdler, S.S.2
  • 58
    • 84902509362 scopus 로고    scopus 로고
    • Estrogenic mediation of serotonergic and neurotrophic systems: Implications for female mood disorders
    • Borrow, A.P. & Cameron, N.M. Estrogenic mediation of serotonergic and neurotrophic systems: implications for female mood disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry 54, 13-25 (2014).
    • (2014) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.54 , pp. 13-25
    • Borrow, A.P.1    Cameron, N.M.2
  • 59
    • 77952383972 scopus 로고    scopus 로고
    • Estrogen receptor neurobiology and its potential for translation into broad-spectrum therapeutics for CNS disorders
    • Hughes, Z.A. et al. Estrogen receptor neurobiology and its potential for translation into broad-spectrum therapeutics for CNS disorders. Curr. Mol. Pharmacol. 2, 215-236 (2009).
    • (2009) Curr. Mol. Pharmacol. , vol.2 , pp. 215-236
    • Hughes, Z.A.1
  • 60
    • 40449104358 scopus 로고    scopus 로고
    • Transient cyclical methylation of promoter DNA
    • Kangaspeska, S. et al. Transient cyclical methylation of promoter DNA. Nature 452, 112-115 (2008).
    • (2008) Nature , vol.452 , pp. 112-115
    • Kangaspeska, S.1
  • 61
    • 84884285513 scopus 로고    scopus 로고
    • Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression
    • Licznerski, P. & Duman, R.S. Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression. Neuroscience 251, 33-50 (2013).
    • (2013) Neuroscience , vol.251 , pp. 33-50
    • Licznerski, P.1    Duman, R.S.2
  • 62
    • 84901478804 scopus 로고    scopus 로고
    • Astrocyte-derived growth factors and estrogen neuroprotection: Role of transforming growth factor-α in estrogen-induced upregulation of glutamate transporters in astrocytes
    • Karki, P., Smith, K., Johnson, J. Jr. & Lee, E. Astrocyte-derived growth factors and estrogen neuroprotection: role of transforming growth factor-α in estrogen-induced upregulation of glutamate transporters in astrocytes. Mol. Cell. Endocrinol. 389, 58-64 (2014).
    • (2014) Mol. Cell. Endocrinol. , vol.389 , pp. 58-64
    • Karki, P.1    Smith, K.2    Johnson, J.3    Lee, E.4
  • 63
    • 79955399440 scopus 로고    scopus 로고
    • 17β-estradiol increases astrocytic vascular endothelial growth factor (VEGF) in adult female rat hippocampus
    • Barouk, S. et al. 17β-estradiol increases astrocytic vascular endothelial growth factor (VEGF) in adult female rat hippocampus. Endocrinology 152, 1745-1751 (2011).
    • (2011) Endocrinology , vol.152 , pp. 1745-1751
    • Barouk, S.1
  • 64
    • 0038771151 scopus 로고    scopus 로고
    • Influence of estradiol, stress and 5-HT2A agonist treatment on brain-derived neurotrophic factor expression in female rats
    • Cavus, I. & Duman, R.S. Influence of estradiol, stress and 5-HT2A agonist treatment on brain-derived neurotrophic factor expression in female rats. Biol. Psychiatry 54, 59-69 (2003).
    • (2003) Biol. Psychiatry , vol.54 , pp. 59-69
    • Cavus, I.1    Duman, R.S.2
  • 65
    • 82055191661 scopus 로고    scopus 로고
    • 17β-estradiol replacement in young, adult and middle-aged female ovariectomized rats promotes improvement of spatial reference memory and an antidepressant effect, and alters monoamines and BDNF levels in memory- and depression-related brain areas
    • Kiss, A. et al. 17β-estradiol replacement in young, adult and middle-aged female ovariectomized rats promotes improvement of spatial reference memory and an antidepressant effect, and alters monoamines and BDNF levels in memory- and depression-related brain areas. Behav. Brain Res. 227, 100-108 (2012).
    • (2012) Behav. Brain Res. , vol.227 , pp. 100-108
    • Kiss, A.1
  • 66
    • 33748702356 scopus 로고    scopus 로고
    • The influence of gonadal hormones on neuronal excitability, seizures and epilepsy in the female
    • Scharfman, H.E. & MacLusky, N.J. The influence of gonadal hormones on neuronal excitability, seizures and epilepsy in the female. Epilepsia 47, 1423-1440 (2006).
    • (2006) Epilepsia , vol.47 , pp. 1423-1440
    • Scharfman, H.E.1    MacLusky, N.J.2
  • 67
    • 33645633313 scopus 로고    scopus 로고
    • Estrogen alters spine number and morphology in prefrontal cortex of aged female rhesus monkeys
    • Hao, J. et al. Estrogen alters spine number and morphology in prefrontal cortex of aged female rhesus monkeys. J. Neurosci. 26, 2571-2578 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 2571-2578
    • Hao, J.1
  • 68
    • 70149091723 scopus 로고    scopus 로고
    • Stress-induced dendritic remodeling in the medial prefrontal cortex: Effects of circuit, hormones and rest
    • Shansky, R.M. & Morrison, J.H. Stress-induced dendritic remodeling in the medial prefrontal cortex: effects of circuit, hormones and rest. Brain Res. 1293, 108-113 (2009).
    • (2009) Brain Res. , vol.1293 , pp. 108-113
    • Shansky, R.M.1    Morrison, J.H.2
  • 69
    • 0026627947 scopus 로고
    • Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat
    • Woolley, C.S. & McEwen, B.S. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J. Neurosci. 12, 2549-2554 (1992).
    • (1992) J. Neurosci. , vol.12 , pp. 2549-2554
    • Woolley, C.S.1    McEwen, B.S.2
  • 70
    • 77949837819 scopus 로고    scopus 로고
    • Estradiol-induced object memory consolidation in middle-aged female mice requires dorsal hippocampal extracellular signal-regulated kinase and phosphatidylinositol 3-kinase activation
    • Fan, L. et al. Estradiol-induced object memory consolidation in middle-aged female mice requires dorsal hippocampal extracellular signal-regulated kinase and phosphatidylinositol 3-kinase activation. J. Neurosci. 30, 4390-4400 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 4390-4400
    • Fan, L.1
  • 71
    • 0030751508 scopus 로고    scopus 로고
    • Intrahippocampal estradiol infusion enhances memory in ovariectomized rats
    • Packard, M.G. & Teather, L.A. Intrahippocampal estradiol infusion enhances memory in ovariectomized rats. Neuroreport 8, 3009-3013 (1997).
    • (1997) Neuroreport , vol.8 , pp. 3009-3013
    • Packard, M.G.1    Teather, L.A.2
  • 72
    • 84899478264 scopus 로고    scopus 로고
    • Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition
    • Wei, J. et al. Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition. Mol. Psychiatry 19, 588-598 (2014).
    • (2014) Mol. Psychiatry , vol.19 , pp. 588-598
    • Wei, J.1
  • 74
    • 78650446029 scopus 로고    scopus 로고
    • Estrogen receptors: Therapies targeted to receptor subtypes
    • Nilsson, S. & Gustafsson, J.A. Estrogen receptors: therapies targeted to receptor subtypes. Clin. Pharmacol. Ther. 89, 44-55 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 44-55
    • Nilsson, S.1    Gustafsson, J.A.2
  • 75
    • 41549089678 scopus 로고    scopus 로고
    • Uncovering the mechanisms of estrogen effects on hippocampal function
    • Spencer, J.L. et al. Uncovering the mechanisms of estrogen effects on hippocampal function. Front. Neuroendocrinol. 29, 219-237 (2008).
    • (2008) Front. Neuroendocrinol. , vol.29 , pp. 219-237
    • Spencer, J.L.1
  • 76
    • 84875154348 scopus 로고    scopus 로고
    • Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus
    • Fortress, A.M., Fan, L., Orr, P.T., Zhao, Z. & Frick, K.M. Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus. Learn. Mem. 20, 147-155 (2013).
    • (2013) Learn. Mem. , vol.20 , pp. 147-155
    • Fortress, A.M.1    Fan, L.2    Orr, P.T.3    Zhao, Z.4    Frick, K.M.5
  • 77
    • 84907750752 scopus 로고    scopus 로고
    • 17β-estradiol regulates histone alterations associated with memory consolidation and increases bdnf promoter acetylation in middle-aged female mice
    • Fortress, A.M., Kim, J., Poole, R.L., Gould, T.J. & Frick, K.M. 17β-estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice. Learn. Mem. 21, 457-467 (2014).
    • (2014) Learn. Mem. , vol.21 , pp. 457-467
    • Fortress, A.M.1    Kim, J.2    Poole, R.L.3    Gould, T.J.4    Frick, K.M.5
  • 78
    • 84869870553 scopus 로고    scopus 로고
    • Diabetes and depression comorbidity and socio-economic status in low- and middle-income countries (LMICs): A mapping of the evidence
    • Leone, T., Coast, E., Narayanan, S. & de Graft Aikins, A. Diabetes and depression comorbidity and socio-economic status in low- and middle-income countries (LMICs): a mapping of the evidence. Global. Health 8, 39 (2012).
    • (2012) Global. Health , vol.8 , pp. 39
    • Leone, T.1    Coast, E.2    Narayanan, S.3    De Graft-Aikins, A.4
  • 79
    • 77649217019 scopus 로고    scopus 로고
    • Overweight, obesity and depression: A systematic review and meta-analysis of longitudinal studies
    • Luppino, F.S. et al. Overweight, obesity and depression: a systematic review and meta-analysis of longitudinal studies. Arch. Gen. Psychiatry 67, 220-229 (2010).
    • (2010) Arch. Gen. Psychiatry , vol.67 , pp. 220-229
    • Luppino, F.S.1
  • 80
    • 84924569218 scopus 로고    scopus 로고
    • Is there a 'metabolic-mood syndrome'? A review of the relationship between obesity and mood disorders
    • Mansur, R.B., Brietzke, E. & McIntyre, R.S. Is there a 'metabolic-mood syndrome'? A review of the relationship between obesity and mood disorders. Neurosci. Biobehav. Rev. 52, 89-104 (2015).
    • (2015) Neurosci. Biobehav. Rev. , vol.52 , pp. 89-104
    • Mansur, R.B.1    Brietzke, E.2    McIntyre, R.S.3
  • 81
    • 84874626443 scopus 로고    scopus 로고
    • Depression and risk of mortality in people with diabetes mellitus: A systematic review and meta-analysis
    • van Dooren, F.E. et al. Depression and risk of mortality in people with diabetes mellitus: a systematic review and meta-analysis. PLoS One 8, e57058 (2013).
    • (2013) PLoS One , vol.8 , pp. e57058
    • Van Dooren, F.E.1
  • 82
    • 84857170815 scopus 로고    scopus 로고
    • Association of depressive disorders, depression characteristics and antidepressant medication with inflammation
    • Vogelzangs, N. et al. Association of depressive disorders, depression characteristics and antidepressant medication with inflammation. Transl. Psychiatry 2, e79 (2012).
    • (2012) Transl. Psychiatry , vol.2 , pp. e79
    • Vogelzangs, N.1
  • 83
    • 84932100510 scopus 로고    scopus 로고
    • Inflammation, obesity and metabolic syndrome in depression: Analysis of the 2009-2010 national health and nutrition examination survey (NHANES)
    • Rethorst, C.D., Bernstein, I. & Trivedi, M.H. Inflammation, obesity and metabolic syndrome in depression: analysis of the 2009-2010 National Health and Nutrition Examination Survey (NHANES). J. Clin. Psychiatry 75, e1428-e1432 (2014).
    • (2014) J. Clin. Psychiatry , vol.75 , pp. e1428-e1432
    • Rethorst, C.D.1    Bernstein, I.2    Trivedi, M.H.3
  • 84
    • 84874021754 scopus 로고    scopus 로고
    • Obesity and C-reactive protein in various populations: A systematic review and meta-analysis
    • Choi, J., Joseph, L. & Pilote, L. Obesity and C-reactive protein in various populations: a systematic review and meta-analysis. Obes. Rev. 14, 232-244 (2013).
    • (2013) Obes. Rev. , vol.14 , pp. 232-244
    • Choi, J.1    Joseph, L.2    Pilote, L.3
  • 85
    • 84864829915 scopus 로고    scopus 로고
    • The hypothalamic-pituitary-adrenal axis and sex hormones in chronic stress and obesity: Pathophysiological and clinical aspects
    • Pasquali, R. The hypothalamic-pituitary-adrenal axis and sex hormones in chronic stress and obesity: pathophysiological and clinical aspects. Ann. NY Acad. Sci. 1264, 20-35 (2012).
    • (2012) Ann. NY Acad. Sci. , vol.1264 , pp. 20-35
    • Pasquali, R.1
  • 86
    • 84929962639 scopus 로고    scopus 로고
    • The link between depression and diabetes: The search for shared mechanisms
    • Moulton, C.D., Pickup, J.C. & Ismail, K. The link between depression and diabetes: the search for shared mechanisms. Lancet Diabetes Endocrinol. 3, 461-471 (2015).
    • (2015) Lancet Diabetes Endocrinol. , vol.3 , pp. 461-471
    • Moulton, C.D.1    Pickup, J.C.2    Ismail, K.3
  • 87
    • 84883182497 scopus 로고    scopus 로고
    • The brain reward circuitry in mood disorders
    • Russo, S.J. & Nestler, E.J. The brain reward circuitry in mood disorders. Nat. Rev. Neurosci. 14, 609-625 (2013).
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 609-625
    • Russo, S.J.1    Nestler, E.J.2
  • 88
    • 78650752631 scopus 로고    scopus 로고
    • Reward, dopamine and the control of food intake: Implications for obesity
    • Volkow, N.D., Wang, G.J. & Baler, R.D. Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn. Sci. 15, 37-46 (2011).
    • (2011) Trends Cogn. Sci. , vol.15 , pp. 37-46
    • Volkow, N.D.1    Wang, G.J.2    Baler, R.D.3
  • 89
    • 51449115268 scopus 로고    scopus 로고
    • Overlapping neuronal circuits in addiction and obesity: Evidence of systems pathology
    • Volkow, N.D., Wang, G.J., Fowler, J.S. & Telang, F. Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology. Phil. Trans. R. Soc. Lond. B 363, 3191-3200 (2008).
    • (2008) Phil. Trans. R. Soc. Lond. B , vol.363 , pp. 3191-3200
    • Volkow, N.D.1    Wang, G.J.2    Fowler, J.S.3    Telang, F.4
  • 90
    • 28444432276 scopus 로고    scopus 로고
    • Metabolism, mood and cognition in aging: The importance of lifestyle and dietary intervention
    • Hendrickx, H., McEwen, B.S. & Ouderaa, Fv. Metabolism, mood and cognition in aging: the importance of lifestyle and dietary intervention. Neurobiol. Aging 26 (suppl. 1), 1-5 (2005).
    • (2005) Neurobiol. Aging , vol.26 , pp. 1-5
    • Hendrickx, H.1    McEwen, B.S.2    Ouderaa, F.3
  • 92
    • 46049083776 scopus 로고    scopus 로고
    • The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
    • Lutter, M. et al. The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat. Neurosci. 11, 752-753 (2008).
    • (2008) Nat. Neurosci. , vol.11 , pp. 752-753
    • Lutter, M.1
  • 93
    • 84942984855 scopus 로고    scopus 로고
    • Ghrelin's role in the hypothalamic-pituitary-adrenal axis stress response: Implications for mood disorders
    • Spencer, S.J., Emmerzaal, T.L., Kozicz, T. & Andrews, Z.B. Ghrelin's role in the hypothalamic-pituitary-adrenal axis stress response: implications for mood disorders. Biol. Psychiatry 78, 19-27 (2015).
    • (2015) Biol. Psychiatry , vol.78 , pp. 19-27
    • Spencer, S.J.1    Emmerzaal, T.L.2    Kozicz, T.3    Andrews, Z.B.4
  • 96
    • 84930275978 scopus 로고    scopus 로고
    • Gut-microbiota-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation
    • Petra, A.I. et al. Gut-microbiota-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation. Clin. Ther. 37, 984-995 (2015).
    • (2015) Clin. Ther. , vol.37 , pp. 984-995
    • Petra, A.I.1
  • 97
    • 84929150186 scopus 로고    scopus 로고
    • Psychobiotics and the gut-brain axis: In the pursuit of happiness
    • Zhou, L. & Foster, J.A. Psychobiotics and the gut-brain axis: in the pursuit of happiness. Neuropsychiatr. Dis. Treat. 11, 715-723 (2015).
    • (2015) Neuropsychiatr. Dis. Treat. , vol.11 , pp. 715-723
    • Zhou, L.1    Foster, J.A.2
  • 98
    • 79954578338 scopus 로고    scopus 로고
    • Beyond the serotonin hypothesis: Mitochondria, inflammation and neurodegeneration in major depression and affective-spectrum disorders
    • Gardner, A. & Boles, R.G. Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective-spectrum disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry 35, 730-743 (2011).
    • (2011) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.35 , pp. 730-743
    • Gardner, A.1    Boles, R.G.2
  • 99
    • 84859988979 scopus 로고    scopus 로고
    • Impaired mitochondrial function in psychiatric disorders
    • Manji, H. et al. Impaired mitochondrial function in psychiatric disorders. Nat. Rev. Neurosci. 13, 293-307 (2012).
    • (2012) Nat. Rev. Neurosci. , vol.13 , pp. 293-307
    • Manji, H.1
  • 100
    • 84914127539 scopus 로고    scopus 로고
    • Glutamate metabolism in major depressive disorder
    • Abdallah, C.G. et al. Glutamate metabolism in major depressive disorder. Am. J. Psychiatry 171, 1320-1327 (2014).
    • (2014) Am. J. Psychiatry , vol.171 , pp. 1320-1327
    • Abdallah, C.G.1
  • 102
  • 103
    • 78651081793 scopus 로고    scopus 로고
    • The metabolic syndrome: Time to get off the merry-go-round?
    • Reaven, G.M. The metabolic syndrome: time to get off the merry-go-round? J. Intern. Med. 269, 127-136 (2011).
    • (2011) J. Intern. Med. , vol.269 , pp. 127-136
    • Reaven, G.M.1
  • 104
    • 84898688392 scopus 로고    scopus 로고
    • High-fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice
    • Arnold, S.E. et al. High-fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice. Neurobiol. Dis. 67, 79-87 (2014).
    • (2014) Neurobiol. Dis. , vol.67 , pp. 79-87
    • Arnold, S.E.1
  • 105
    • 0034718561 scopus 로고    scopus 로고
    • Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress
    • Magariños, A.M. & McEwen, B.S. Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress. Proc. Natl. Acad. Sci. USA 97, 11056-11061 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11056-11061
    • Magariños, A.M.1    McEwen, B.S.2
  • 106
    • 55549139200 scopus 로고    scopus 로고
    • Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
    • Stranahan, A.M. et al. Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 18, 1085-1088 (2008).
    • (2008) Hippocampus , vol.18 , pp. 1085-1088
    • Stranahan, A.M.1
  • 107
    • 84856467949 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor-mediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signaling pathways
    • Markham, A. et al. Brain-derived neurotrophic factor-mediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signaling pathways. Eur. J. Neurosci. 35, 366-374 (2012).
    • (2012) Eur. J. Neurosci. , vol.35 , pp. 366-374
    • Markham, A.1
  • 108
    • 84893021363 scopus 로고    scopus 로고
    • BDNF mediates adaptive brain and body responses to energetic challenges
    • Marosi, K. & Mattson, M.P. BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol. Metab. 25, 89-98 (2014).
    • (2014) Trends Endocrinol. Metab. , vol.25 , pp. 89-98
    • Marosi, K.1    Mattson, M.P.2
  • 109
    • 84859603926 scopus 로고    scopus 로고
    • Hypothalamic BDNF and obesity: Found in translation
    • Schwartz, E. & Mobbs, C.V. Hypothalamic BDNF and obesity: found in translation. Nat. Med. 18, 496-497 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 496-497
    • Schwartz, E.1    Mobbs, C.V.2
  • 110
    • 37549055474 scopus 로고    scopus 로고
    • Selective deletion of bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity
    • Unger, T.J., Calderon, G.A., Bradley, L.C., Sena-Esteves, M. & Rios, M. Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J. Neurosci. 27, 14265-14274 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 14265-14274
    • Unger, T.J.1    Calderon, G.A.2    Bradley, L.C.3    Sena-Esteves, M.4    Rios, M.5
  • 111
    • 84925307917 scopus 로고    scopus 로고
    • Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
    • Kleinridders, A. et al. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. Proc. Natl. Acad. Sci. USA 112, 3463-3468 (2015).
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 3463-3468
    • Kleinridders, A.1
  • 112
    • 84907486069 scopus 로고    scopus 로고
    • Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression
    • Agudelo, L.Z. et al. Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell 159, 33-45 (2014).
    • (2014) Cell , vol.159 , pp. 33-45
    • Agudelo, L.Z.1
  • 113
    • 84884502539 scopus 로고    scopus 로고
    • Bridging animal and human models of exercise-induced brain plasticity
    • Voss, M.W., Vivar, C., Kramer, A.F. & van Praag, H. Bridging animal and human models of exercise-induced brain plasticity. Trends Cogn. Sci. 17, 525-544 (2013).
    • (2013) Trends Cogn. Sci. , vol.17 , pp. 525-544
    • Voss, M.W.1    Vivar, C.2    Kramer, A.F.3    Van Praag, H.4
  • 114
    • 57749193787 scopus 로고    scopus 로고
    • Inflammatory markers in depression
    • Dinan, T.G. Inflammatory markers in depression. Curr. Opin. Psychiatry 22, 32-36 (2009).
    • (2009) Curr. Opin. Psychiatry , vol.22 , pp. 32-36
    • Dinan, T.G.1
  • 115
    • 84878124765 scopus 로고    scopus 로고
    • The inflammasome: Pathways linking psychological stress, depression and systemic illnesses
    • Iwata, M., Ota, K.T. & Duman, R.S. The inflammasome: pathways linking psychological stress, depression and systemic illnesses. Brain Behav. Immun. 31, 105-114 (2013).
    • (2013) Brain Behav. Immun. , vol.31 , pp. 105-114
    • Iwata, M.1    Ota, K.T.2    Duman, R.S.3
  • 116
    • 63449122724 scopus 로고    scopus 로고
    • Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression
    • Miller, A.H., Maletic, V. & Raison, C.L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 65, 732-741 (2009).
    • (2009) Biol. Psychiatry , vol.65 , pp. 732-741
    • Miller, A.H.1    Maletic, V.2    Raison, C.L.3
  • 117
    • 30544445602 scopus 로고    scopus 로고
    • Cytokines sing the blues: Inflammation and the pathogenesis of depression
    • Raison, C.L., Capuron, L. & Miller, A.H. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 27, 24-31 (2006).
    • (2006) Trends Immunol. , vol.27 , pp. 24-31
    • Raison, C.L.1    Capuron, L.2    Miller, A.H.3
  • 118
    • 75849155537 scopus 로고    scopus 로고
    • A meta-analysis of cytokines in major depression
    • Dowlati, Y. et al. A meta-analysis of cytokines in major depression. Biol. Psychiatry 67, 446-457 (2010).
    • (2010) Biol. Psychiatry , vol.67 , pp. 446-457
    • Dowlati, Y.1
  • 119
    • 65649152524 scopus 로고    scopus 로고
    • Associations of depression with C-reactive protein, IL-1 and IL-6: A meta-analysis
    • Howren, M.B., Lamkin, D.M. & Suls, J. Associations of depression with C-reactive protein, IL-1 and IL-6: a meta-analysis. Psychosom. Med. 71, 171-186 (2009).
    • (2009) Psychosom. Med. , vol.71 , pp. 171-186
    • Howren, M.B.1    Lamkin, D.M.2    Suls, J.3
  • 120
    • 84878155936 scopus 로고    scopus 로고
    • Malaise, melancholia and madness: The evolutionary legacy of an inflammatory bias
    • Raison, C.L. & Miller, A.H. Malaise, melancholia and madness: the evolutionary legacy of an inflammatory bias. Brain Behav. Immun. 31, 1-8 (2013).
    • (2013) Brain Behav. Immun. , vol.31 , pp. 1-8
    • Raison, C.L.1    Miller, A.H.2
  • 121
    • 84955611614 scopus 로고    scopus 로고
    • Psychological stress activates the inflammasome via release of ATP and stimulation of the P2X7 receptor
    • (8 December)
    • Iwata, M. et al. Psychological stress activates the inflammasome via release of ATP and stimulation of the P2X7 receptor. Biol. Psychiatry doi:10.1016/j.biopsych.2015.11.026 (8 December 2015).
    • (2015) Biol. Psychiatry
    • Iwata, M.1
  • 122
    • 70349794451 scopus 로고    scopus 로고
    • Immune proteins in brain development and synaptic plasticity
    • Boulanger, L.M. Immune proteins in brain development and synaptic plasticity. Neuron 64, 93-109 (2009).
    • (2009) Neuron , vol.64 , pp. 93-109
    • Boulanger, L.M.1
  • 123
    • 36048932754 scopus 로고    scopus 로고
    • A dual role for interleukin-1 in hippocampal-dependent memory processes
    • Goshen, I. et al. A dual role for interleukin-1 in hippocampal-dependent memory processes. Psychoneuroendocrinology 32, 1106-1115 (2007).
    • (2007) Psychoneuroendocrinology , vol.32 , pp. 1106-1115
    • Goshen, I.1
  • 124
    • 67649221730 scopus 로고    scopus 로고
    • A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder
    • Khairova, R.A., Machado-Vieira, R., Du, J. & Manji, H.K. A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int. J. Neuropsychopharmacol. 12, 561-578 (2009).
    • (2009) Int. J. Neuropsychopharmacol , vol.12 , pp. 561-578
    • Khairova, R.A.1    Machado-Vieira, R.2    Du, J.3    Manji, H.K.4
  • 125
    • 0032523168 scopus 로고    scopus 로고
    • Evidence that increased hippocampal expression of the cytokine interleukin-1β is a common trigger for age- and stress-induced impairments in long-term potentiation
    • Murray, C.A. & Lynch, M.A. Evidence that increased hippocampal expression of the cytokine interleukin-1β is a common trigger for age- and stress-induced impairments in long-term potentiation. J. Neurosci. 18, 2974-2981 (1998).
    • (1998) J. Neurosci. , vol.18 , pp. 2974-2981
    • Murray, C.A.1    Lynch, M.A.2
  • 126
    • 33646199097 scopus 로고    scopus 로고
    • Synaptic scaling mediated by glial TNF-α
    • Stellwagen, D. & Malenka, R.C. Synaptic scaling mediated by glial TNF-α. Nature 440, 1054-1059 (2006).
    • (2006) Nature , vol.440 , pp. 1054-1059
    • Stellwagen, D.1    Malenka, R.C.2
  • 127
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • Paolicelli, R.C. et al. Synaptic pruning by microglia is necessary for normal brain development. Science 333, 1456-1458 (2011).
    • (2011) Science , vol.333 , pp. 1456-1458
    • Paolicelli, R.C.1
  • 128
    • 84861427387 scopus 로고    scopus 로고
    • Microglia sculpt postnatal neural circuits in an activity- and complement-dependent manner
    • Schafer, D.P. et al. Microglia sculpt postnatal neural circuits in an activity- and complement-dependent manner. Neuron 74, 691-705 (2012).
    • (2012) Neuron , vol.74 , pp. 691-705
    • Schafer, D.P.1
  • 129
    • 84860338445 scopus 로고    scopus 로고
    • The complement system: An unexpected role in synaptic pruning during development and disease
    • Stephan, A.H., Barres, B.A. & Stevens, B. The complement system: an unexpected role in synaptic pruning during development and disease. Annu. Rev. Neurosci. 35, 369-389 (2012).
    • (2012) Annu. Rev. Neurosci. , vol.35 , pp. 369-389
    • Stephan, A.H.1    Barres, B.A.2    Stevens, B.3
  • 130
    • 35348832393 scopus 로고    scopus 로고
    • Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions
    • Krishnan, V. et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131, 391-404 (2007).
    • (2007) Cell , vol.131 , pp. 391-404
    • Krishnan, V.1
  • 131
    • 84871986003 scopus 로고    scopus 로고
    • A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: The role of baseline inflammatory biomarkers
    • Raison, C.L. et al. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry 70, 31-41 (2013).
    • (2013) JAMA Psychiatry , vol.70 , pp. 31-41
    • Raison, C.L.1
  • 132
    • 84877153207 scopus 로고    scopus 로고
    • Neuronal plasticity and antidepressant actions
    • Castrén, E. & Hen, R. Neuronal plasticity and antidepressant actions. Trends Neurosci. 36, 259-267 (2013).
    • (2013) Trends Neurosci. , vol.36 , pp. 259-267
    • Castrén, E.1    Hen, R.2
  • 133
    • 78349241786 scopus 로고    scopus 로고
    • Linking molecules to mood: New insight into the biology of depression
    • Krishnan, V. & Nestler, E.J. Linking molecules to mood: new insight into the biology of depression. Am. J. Psychiatry 167, 1305-1320 (2010).
    • (2010) Am. J. Psychiatry , vol.167 , pp. 1305-1320
    • Krishnan, V.1    Nestler, E.J.2
  • 134
    • 84907483716 scopus 로고    scopus 로고
    • The current state of the neurogenic theory of depression and anxiety
    • Miller, B.R. & Hen, R. The current state of the neurogenic theory of depression and anxiety. Curr. Opin. Neurobiol. 30, 51-58 (2015).
    • (2015) Curr. Opin. Neurobiol. , vol.30 , pp. 51-58
    • Miller, B.R.1    Hen, R.2
  • 135
    • 33749649795 scopus 로고    scopus 로고
    • Val66Met polymorphism alters anxiety-related behavior
    • Val66Met polymorphism alters anxiety-related behavior. Science 314, 140-143 (2006b).
    • (2006) Science , vol.314 , pp. 140-143
    • Chen, Z.-Y.1
  • 136
    • 84855297758 scopus 로고    scopus 로고
    • Signaling pathways underlying the pathophysiology and treatment of depression: Novel mechanisms for rapid-acting agents
    • Duman, R.S. & Voleti, B. Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents. Trends Neurosci. 35, 47-56 (2012).
    • (2012) Trends Neurosci. , vol.35 , pp. 47-56
    • Duman, R.S.1    Voleti, B.2
  • 137
    • 84863380672 scopus 로고    scopus 로고
    • Variant brain-derived neurotrophic factor val66met polymorphism alters vulnerability to stress and response to antidepressants
    • Yu, H. et al. Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants. J. Neurosci. 32, 4092-4101 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 4092-4101
    • Yu, H.1
  • 138
    • 84939128522 scopus 로고    scopus 로고
    • SKF83959 produces antidepressant effects in a chronic social-defeat stress model of depression through the BDNF-TrkB pathway
    • Jiang, B. et al. SKF83959 produces antidepressant effects in a chronic social-defeat stress model of depression through the BDNF-TrkB pathway. Int. J. Neuropsychopharmacol. 18, pyu096 (2015).
    • (2015) Int. J. Neuropsychopharmacol , vol.18 , pp. pyu096
    • Jiang, B.1
  • 139
    • 84928035087 scopus 로고    scopus 로고
    • Hippocampal structural and functional changes associated with electroconvulsive therapy response
    • Abbott, C.C. et al. Hippocampal structural and functional changes associated with electroconvulsive therapy response. Transl. Psychiatry 4, e483 (2014).
    • (2014) Transl. Psychiatry , vol.4 , pp. e483
    • Abbott, C.C.1
  • 140
    • 84892926285 scopus 로고    scopus 로고
    • Electroconvulsive therapy-induced brain plasticity determines therapeutic outcome in mood disorders
    • Dukart, J. et al. Electroconvulsive therapy-induced brain plasticity determines therapeutic outcome in mood disorders. Proc. Natl. Acad. Sci. USA 111, 1156-1161 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 1156-1161
    • Dukart, J.1
  • 141
    • 84858338665 scopus 로고    scopus 로고
    • Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity
    • Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity. Neuropsychopharmacology 37, 1297-1304 (2012).
    • (2012) Neuropsychopharmacology , vol.37 , pp. 1297-1304
    • Bath, K.G.1
  • 142
    • 84455171593 scopus 로고    scopus 로고
    • Fear erasure in mice requires synergy between antidepressant drugs and extinction training
    • Karpova, N.N. et al. Fear erasure in mice requires synergy between antidepressant drugs and extinction training. Science 334, 1731-1734 (2011).
    • (2011) Science , vol.334 , pp. 1731-1734
    • Karpova, N.N.1
  • 143
    • 42349094651 scopus 로고    scopus 로고
    • The antidepressant fluoxetine restores plasticity in the adult visual cortex
    • Maya Vetencourt, J.F. et al. The antidepressant fluoxetine restores plasticity in the adult visual cortex. Science 320, 385-388 (2008).
    • (2008) Science , vol.320 , pp. 385-388
    • Maya Vetencourt, J.F.1
  • 144
    • 77953807421 scopus 로고    scopus 로고
    • Chronic fluoxetine treatment induces structural plasticity and selective changes in glutamate receptor subunits in the rat cerebral cortex
    • Ampuero, E. et al. Chronic fluoxetine treatment induces structural plasticity and selective changes in glutamate receptor subunits in the rat cerebral cortex. Neuroscience 169, 98-108 (2010).
    • (2010) Neuroscience , vol.169 , pp. 98-108
    • Ampuero, E.1
  • 145
    • 67651149865 scopus 로고    scopus 로고
    • Hippocampal neurogenesis induced by antidepressant drugs: An epiphenomenon in their mood-improving actions
    • Bessa, J. et al. Hippocampal neurogenesis induced by antidepressant drugs: an epiphenomenon in their mood-improving actions. Mol. Psychiatry 14, 739 (2009).
    • (2009) Mol. Psychiatry , vol.14 , pp. 739
    • Bessa, J.1
  • 146
    • 0029146057 scopus 로고
    • Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Comparison of stressors
    • Magariños, A.M. & McEwen, B.S. Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: comparison of stressors. Neuroscience 69, 83-88 (1995a).
    • (1995) Neuroscience , vol.69 , pp. 83-88
    • Magariños, A.M.1    McEwen, B.S.2
  • 147
    • 14844298782 scopus 로고    scopus 로고
    • Is mood chemistry?
    • Castrén, E. Is mood chemistry? Nat. Rev. Neurosci. 6, 241-246 (2005).
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 241-246
    • Castrén, E.1
  • 148
    • 0033969685 scopus 로고    scopus 로고
    • Antidepressant effects of ketamine in depressed patients
    • Berman, R.M. et al. Antidepressant effects of ketamine in depressed patients. Biol. Psychiatry 47, 351-354 (2000).
    • (2000) Biol. Psychiatry , vol.47 , pp. 351-354
    • Berman, R.M.1
  • 149
    • 77955891255 scopus 로고    scopus 로고
    • A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression
    • Diazgranados, N. et al. A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression. Arch. Gen. Psychiatry 67, 793-802 (2010).
    • (2010) Arch. Gen. Psychiatry , vol.67 , pp. 793-802
    • Diazgranados, N.1
  • 150
    • 33746896935 scopus 로고    scopus 로고
    • A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
    • Zarate, C.A. Jr. et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch. Gen. Psychiatry 63, 856-864 (2006).
    • (2006) Arch. Gen. Psychiatry , vol.63 , pp. 856-864
    • Zarate, C.A.1
  • 151
    • 78650371169 scopus 로고    scopus 로고
    • Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder
    • Diaz Granados, N. et al. Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder. J. Clin. Psychiatry 71, 1605-1611 (2010).
    • (2010) J. Clin. Psychiatry , vol.71 , pp. 1605-1611
    • Diaz Granados, N.1
  • 152
    • 68049121850 scopus 로고    scopus 로고
    • Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression
    • Price, R.B., Nock, M.K., Charney, D.S. & Mathew, S.J. Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression. Biol. Psychiatry 66, 522-526 (2009).
    • (2009) Biol. Psychiatry , vol.66 , pp. 522-526
    • Price, R.B.1    Nock, M.K.2    Charney, D.S.3    Mathew, S.J.4
  • 153
    • 75849117116 scopus 로고    scopus 로고
    • Replication of Scopolamine's antidepressant efficacy in major depressive disorder: A randomized, placebo-controlled clinical trial
    • Drevets, W.C. & Furey, M.L. Replication of scopolamine's antidepressant efficacy in major depressive disorder: a randomized, placebo-controlled clinical trial. Biol. Psychiatry 67, 432-438 (2010).
    • (2010) Biol. Psychiatry , vol.67 , pp. 432-438
    • Drevets, W.C.1    Furey, M.L.2
  • 154
    • 84949089102 scopus 로고    scopus 로고
    • The promise of ketamine for treatment-resistant depression: Current evidence and future directions
    • DeWilde, K.E., Levitch, C.F., Murrough, J.W., Mathew, S.J. & Iosifescu, D.V. The promise of ketamine for treatment-resistant depression: current evidence and future directions. Ann. NY Acad. Sci. 1345, 47-58 (2015).
    • (2015) Ann. NY Acad. Sci. , vol.1345 , pp. 47-58
    • DeWilde, K.E.1    Levitch, C.F.2    Murrough, J.W.3    Mathew, S.J.4    Iosifescu, D.V.5
  • 155
    • 84924690161 scopus 로고    scopus 로고
    • Ketamine: Promising path or false prophecy in the development of novel therapeutics for mood disorders?
    • Sanacora, G. & Schatzberg, A.F. Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders? Neuropsychopharmacology 40, 1307 (2015).
    • (2015) Neuropsychopharmacology , vol.40 , pp. 1307
    • Sanacora, G.1    Schatzberg, A.F.2
  • 156
    • 84920270347 scopus 로고    scopus 로고
    • GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine
    • Miller, O.H. et al. GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine. eLife 3, e03581 (2014).
    • (2014) ELife , vol.3 , pp. e03581
    • Miller, O.H.1
  • 157
    • 84902817599 scopus 로고    scopus 로고
    • (R,S)-ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase mammalian target of rapamycin function
    • Paul, R.K. et al. (R,S)-ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase mammalian target of rapamycin function. Anesthesiology 121, 149-159 (2014).
    • (2014) Anesthesiology , vol.121 , pp. 149-159
    • Paul, R.K.1
  • 158
    • 84911472465 scopus 로고    scopus 로고
    • Ketamine-induced antidepressant effects are associated with AMPA receptor-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex
    • Zhou, W. et al. Ketamine-induced antidepressant effects are associated with AMPA receptor-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex. Eur. Psychiatry 29, 419-423 (2014).
    • (2014) Eur. Psychiatry , vol.29 , pp. 419-423
    • Zhou, W.1
  • 159
    • 84937164747 scopus 로고    scopus 로고
    • Ketamine strengthens CRF-activated amygdala inputs to basal dendrites in mPFC layer v pyramidal cells in the prelimbic but not the infralimbic subregion, a key suppressor of stress responses
    • Liu, R.J., Ota, K.T., Dutheil, S., Duman, R.S. & Aghajanian, G.K. Ketamine strengthens CRF-activated amygdala inputs to basal dendrites in mPFC layer V pyramidal cells in the prelimbic but not the infralimbic subregion, a key suppressor of stress responses. Neuropsychopharmacology 40, 2066-2075 (2015).
    • (2015) Neuropsychopharmacology , vol.40 , pp. 2066-2075
    • Liu, R.J.1    Ota, K.T.2    Dutheil, S.3    Duman, R.S.4    Aghajanian, G.K.5
  • 160
    • 38349186799 scopus 로고    scopus 로고
    • Cellular mechanisms underlying the antidepressant effects of ketamine: Role of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
    • Maeng, S. et al. Cellular mechanisms underlying the antidepressant effects of ketamine: role of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol. Psychiatry 63, 349-352 (2008).
    • (2008) Biol. Psychiatry , vol.63 , pp. 349-352
    • Maeng, S.1
  • 161
    • 35548991088 scopus 로고    scopus 로고
    • NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons
    • Homayoun, H. & Moghaddam, B. NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons. J. Neurosci. 27, 11496-11500 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 11496-11500
    • Homayoun, H.1    Moghaddam, B.2
  • 162
    • 84862754626 scopus 로고    scopus 로고
    • 1H-MRS: Relationship to ketamine-induced psychopathology
    • 1H-MRS: relationship to ketamine-induced psychopathology. Mol. Psychiatry 17, 664-665 (2012).
    • (2012) Mol. Psychiatry , vol.17 , pp. 664-665
    • Stone, J.M.1
  • 163
    • 7744224557 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites
    • Takei, N. et al. Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. J. Neurosci. 24, 9760-9769 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 9760-9769
    • Takei, N.1
  • 164
    • 79960057257 scopus 로고    scopus 로고
    • NMDA receptor blockade at rest triggers rapid behavioral antidepressant responses
    • Autry, A.E. et al. NMDA receptor blockade at rest triggers rapid behavioral antidepressant responses. Nature 475, 91-95 (2011).
    • (2011) Nature , vol.475 , pp. 91-95
    • Autry, A.E.1
  • 165
    • 84857083262 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor val66met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex
    • Liu, R.J. et al. Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biol. Psychiatry 71, 996-1005 (2012).
    • (2012) Biol. Psychiatry , vol.71 , pp. 996-1005
    • Liu, R.J.1
  • 166
    • 84894042786 scopus 로고    scopus 로고
    • Sub-anesthetic ketamine modulates intrinsic BOLD connectivity within the hippocampal-prefrontal circuit in the rat
    • Gass, N. et al. Sub-anesthetic ketamine modulates intrinsic BOLD connectivity within the hippocampal-prefrontal circuit in the rat. Neuropsychopharmacology 39, 895-906 (2014).
    • (2014) Neuropsychopharmacology , vol.39 , pp. 895-906
    • Gass, N.1
  • 167
    • 84927731898 scopus 로고    scopus 로고
    • Regulation of neural responses to emotion perception by ketamine in individuals with treatment-resistant major depressive disorder
    • Murrough, J.W. et al. Regulation of neural responses to emotion perception by ketamine in individuals with treatment-resistant major depressive disorder. Transl. Psychiatry 5, e509 (2015).
    • (2015) Transl. Psychiatry , vol.5 , pp. e509
    • Murrough, J.W.1
  • 168
    • 84892820726 scopus 로고    scopus 로고
    • A placebo-controlled trial of the NR2B subunit-specific NMDA antagonist CP-101,606 plus paroxetine for treatment-resistant depression (TRD)
    • (American Psychological Association, Washington, D.C.)
    • Preskorn, S. et al. A placebo-controlled trial of the NR2B subunit-specific NMDA antagonist CP-101,606 plus paroxetine for treatment-resistant depression (TRD). (115th Annual Meeting of the American Psychological Association) (American Psychological Association, Washington, D.C., 2007).
    • (2007) 115th Annual Meeting of the American Psychological Association
    • Preskorn, S.1
  • 169
    • 84908572031 scopus 로고    scopus 로고
    • Lanicemine: A low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects
    • Sanacora, G. et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Mol. Psychiatry 19, 978-985 (2014).
    • (2014) Mol. Psychiatry , vol.19 , pp. 978-985
    • Sanacora, G.1
  • 170
    • 34249083509 scopus 로고    scopus 로고
    • Pharmacology of ampakine modulators: From AMPA receptors to synapses and behavior
    • Arai, A.C. & Kessler, M. Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior. Curr. Drug Targets 8, 583-602 (2007).
    • (2007) Curr. Drug Targets , vol.8 , pp. 583-602
    • Arai, A.C.1    Kessler, M.2
  • 171
    • 38949115944 scopus 로고    scopus 로고
    • Mood disorders: Regulation by metabotropic glutamate receptors
    • Pilc, A., Chaki, S., Nowak, G. & Witkin, J.M. Mood disorders: regulation by metabotropic glutamate receptors. Biochem. Pharmacol. 75, 997-1006 (2008).
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 997-1006
    • Pilc, A.1    Chaki, S.2    Nowak, G.3    Witkin, J.M.4
  • 172
    • 78149305869 scopus 로고    scopus 로고
    • A negative regulator of MAP kinase causes depressive behavior
    • Duric, V. et al. A negative regulator of MAP kinase causes depressive behavior. Nat. Med. 16, 1328-1332 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 1328-1332
    • Duric, V.1
  • 173
    • 84934269718 scopus 로고    scopus 로고
    • 1-subtype muscarinic acetylcholine receptors
    • 1-subtype muscarinic acetylcholine receptors. Neurobiol. Dis. 82, 254-261 (2015).
    • (2015) Neurobiol. Dis. , vol.82 , pp. 254-261
    • Navarria, A.1
  • 174
    • 84908120351 scopus 로고    scopus 로고
    • 2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine
    • 2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine. J. Pharmacol. Exp. Ther. 351, 448-456 (2014).
    • (2014) J. Pharmacol. Exp. Ther. , vol.351 , pp. 448-456
    • Witkin, J.M.1
  • 175
    • 84939194287 scopus 로고    scopus 로고
    • Lurasidone exerts antidepressant properties in the chronic mild-stress model through the regulation of synaptic and neuroplastic mechanisms in the rat prefrontal cortex
    • Luoni, A., Macchi, F., Papp, M., Molteni, R. & Riva, M.A. Lurasidone exerts antidepressant properties in the chronic mild-stress model through the regulation of synaptic and neuroplastic mechanisms in the rat prefrontal cortex. Int. J. Neuropsychopharmacol. 18, pyu061 (2015).
    • (2015) Int. J. Neuropsychopharmacol , vol.18 , pp. pyu061
    • Luoni, A.1    Macchi, F.2    Papp, M.3    Molteni, R.4    Riva, M.A.5
  • 176
    • 84883386093 scopus 로고    scopus 로고
    • Antidepressant-like effects of erythropoietin: A focus on behavioral and hippocampal processes
    • Osborn, M. et al. Antidepressant-like effects of erythropoietin: a focus on behavioral and hippocampal processes. PLoS One 8, e72813 (2013).
    • (2013) PLoS One , vol.8 , pp. e72813
    • Osborn, M.1
  • 177
    • 84897994660 scopus 로고    scopus 로고
    • Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats
    • Pałucha-Poniewiera, A., Szewczyk, B. & Pilc, A. Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats. Neuropharmacology 82, 59-68 (2014).
    • (2014) Neuropharmacology , vol.82 , pp. 59-68
    • Pałucha-Poniewiera, A.1    Szewczyk, B.2    Pilc, A.3
  • 178
    • 84900565127 scopus 로고    scopus 로고
    • Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling
    • Zhong, P. et al. Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling. Neuropsychopharmacology 39, 1763-1776 (2014).
    • (2014) Neuropsychopharmacology , vol.39 , pp. 1763-1776
    • Zhong, P.1
  • 179
    • 0033810465 scopus 로고    scopus 로고
    • Genetic epidemiology of major depression: Review and meta-analysis
    • Sullivan, P.F., Neale, M.C. & Kendler, K.S. Genetic epidemiology of major depression: review and meta-analysis. Am. J. Psychiatry 157, 1552-1562 (2000).
    • (2000) Am. J. Psychiatry , vol.157 , pp. 1552-1562
    • Sullivan, P.F.1    Neale, M.C.2    Kendler, K.S.3
  • 180
    • 47749123329 scopus 로고    scopus 로고
    • Meta-analyses of genetic studies on major depressive disorder
    • López-León, S. et al. Meta-analyses of genetic studies on major depressive disorder. Mol. Psychiatry 13, 772-785 (2008).
    • (2008) Mol. Psychiatry , vol.13 , pp. 772-785
    • López-León, S.1
  • 181
    • 84922544557 scopus 로고    scopus 로고
    • Genetic studies of major depressive disorder: Why are there no genome-wide association study findings and what can we do about it?
    • Levinson, D.F. et al. Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it? Biol. Psychiatry 76, 510-512 (2014).
    • (2014) Biol. Psychiatry , vol.76 , pp. 510-512
    • Levinson, D.F.1
  • 182
    • 84923077204 scopus 로고    scopus 로고
    • Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
    • Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat. Neurosci. 18, 199-209 (2015).
    • (2015) Nat. Neurosci. , vol.18 , pp. 199-209
  • 183
    • 10344238087 scopus 로고    scopus 로고
    • Social supports and serotonin transporter gene moderate depression in maltreated children
    • Kaufman, J. et al. Social supports and serotonin transporter gene moderate depression in maltreated children. Proc. Natl. Acad. Sci. USA 101, 17316-17321 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 17316-17321
    • Kaufman, J.1
  • 184
    • 84898645098 scopus 로고    scopus 로고
    • Epigenetic mechanisms of depression
    • Nestler, E.J. Epigenetic mechanisms of depression. JAMA Psychiatry 71, 454-456 (2014).
    • (2014) JAMA Psychiatry , vol.71 , pp. 454-456
    • Nestler, E.J.1
  • 185
    • 84922883570 scopus 로고    scopus 로고
    • Epigenetic mechanisms underlying learning and the inheritance of learned behaviors
    • Dias, B.G., Maddox, S.A., Klengel, T. & Ressler, K.J. Epigenetic mechanisms underlying learning and the inheritance of learned behaviors. Trends Neurosci. 38, 96-107 (2015).
    • (2015) Trends Neurosci. , vol.38 , pp. 96-107
    • Dias, B.G.1    Maddox, S.A.2    Klengel, T.3    Ressler, K.J.4
  • 186
    • 84655163444 scopus 로고    scopus 로고
    • Cross-species studies of orbitofrontal cortex and value-based decision-making
    • Wallis, J.D. Cross-species studies of orbitofrontal cortex and value-based decision-making. Nat. Neurosci. 15, 13-19 (2012).
    • (2012) Nat. Neurosci. , vol.15 , pp. 13-19
    • Wallis, J.D.1
  • 187
    • 0029622977 scopus 로고
    • Sensory and premotor connections of the orbital and medial prefrontal cortex of macaque monkeys
    • Carmichael, S.T. & Price, J.L. Sensory and premotor connections of the orbital and medial prefrontal cortex of macaque monkeys. J. Comp. Neurol. 363, 642-664 (1995).
    • (1995) J. Comp. Neurol. , vol.363 , pp. 642-664
    • Carmichael, S.T.1    Price, J.L.2
  • 188
    • 0029076348 scopus 로고
    • The orbital and medial prefrontal circuit through the primate basal ganglia
    • Haber, S.N., Kunishio, K., Mizobuchi, M. & Lynd-Balta, E. The orbital and medial prefrontal circuit through the primate basal ganglia. J. Neurosci. 15, 4851-4867 (1995).
    • (1995) J. Neurosci. , vol.15 , pp. 4851-4867
    • Haber, S.N.1    Kunishio, K.2    Mizobuchi, M.3    Lynd-Balta, E.4
  • 189
    • 1942511158 scopus 로고    scopus 로고
    • Architectonic subdivision of the human orbital and medial prefrontal cortex
    • Ongür, D., Ferry, A.T. & Price, J.L. Architectonic subdivision of the human orbital and medial prefrontal cortex. J. Comp. Neurol. 460, 425-449 (2003).
    • (2003) J. Comp. Neurol. , vol.460 , pp. 425-449
    • Ongür, D.1    Ferry, A.T.2    Price, J.L.3
  • 191
    • 49949089662 scopus 로고    scopus 로고
    • A neural model of voluntary and automatic emotion regulation: Implications for understanding the pathophysiology and neurodevelopment of bipolar disorder
    • Phillips, M.L., Ladouceur, C.D. & Drevets, W.C. A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol. Psychiatry 13 829, 833-857 (2008).
    • (2008) Mol. Psychiatry , vol.13 , Issue.829 , pp. 833-857
    • Phillips, M.L.1    Ladouceur, C.D.2    Drevets, W.C.3
  • 192
    • 0242580988 scopus 로고    scopus 로고
    • Differential projections of the infralimbic and prelimbic cortex in the rat
    • Vertes, R.P. Differential projections of the infralimbic and prelimbic cortex in the rat. Synapse 51, 32-58 (2004).
    • (2004) Synapse , vol.51 , pp. 32-58
    • Vertes, R.P.1
  • 193
    • 84886889124 scopus 로고    scopus 로고
    • The infralimbic cortex bidirectionally modulates mesolimbic dopamine neuron activity via distinct neural pathways
    • Patton, M.H., Bizup, B.T. & Grace, A.A. The infralimbic cortex bidirectionally modulates mesolimbic dopamine neuron activity via distinct neural pathways. J. Neurosci. 33, 16865-16873 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 16865-16873
    • Patton, M.H.1    Bizup, B.T.2    Grace, A.A.3
  • 194
    • 84922241944 scopus 로고    scopus 로고
    • Identifying predictors, moderators and mediators of antidepressant response in major depressive disorder: Neuroimaging approaches
    • Phillips, M.L. et al. Identifying predictors, moderators and mediators of antidepressant response in major depressive disorder: neuroimaging approaches. Am. J. Psychiatry 172, 124-138 (2015).
    • (2015) Am. J. Psychiatry , vol.172 , pp. 124-138
    • Phillips, M.L.1
  • 195
    • 84897114163 scopus 로고    scopus 로고
    • Depression, stress and anhedonia: Toward a synthesis and integrated model
    • Pizzagalli, D.A. Depression, stress and anhedonia: toward a synthesis and integrated model. Annu. Rev. Clin. Psychol. 10, 393-423 (2014).
    • (2014) Annu. Rev. Clin. Psychol. , vol.10 , pp. 393-423
    • Pizzagalli, D.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.