Experience strengthening transmission by driving AMPA receptors into synapses

Science

Volumn 299, Issue 5612, 2003, Pages 1585-1588

  Takahashi, Takuya ^a   Svoboda, Karel ^b   Malinow, Roberto ^a  

^a Jones Laboratory   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; GENES; NEUROLOGY;

SYNAPSES;

BRAIN;

AMPA RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 1; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

BRAIN; PLASTICITY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPERIENCE; GENE TARGETING; LONG TERM POTENTIATION; MAMMAL; MEMORY CONSOLIDATION; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; SOMATOSENSORY CORTEX; STIMULUS; SYNAPSE;

ANIMALS; ELECTROPHYSIOLOGY; GENE TRANSFER TECHNIQUES; LONG-TERM POTENTIATION; NEURONAL PLASTICITY; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, AMPA; RECOMBINANT FUSION PROTEINS; SINDBIS VIRUS; SOMATOSENSORY CORTEX; SYNAPSES; SYNAPTIC TRANSMISSION; TOUCH; VIBRISSAE;

ANIMALIA; MAMMALIA;

EID: 0242418160     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1079886     Document Type: Article

References (32)

1. S. J. Martin, P. D. Grimwood, R. G. Morris, Annu. Rev. Neurosci. 23, 649 (2000).
2. D. V. Buonomano, M. M. Merzenich, Annu. Rev. Neurosci. 21, 149 (1998).
3. M. F. Bear, Proc. Natl. Acad. Sci. U.S.A. 96, 9457 (1999).
4. K. Fox, Neuroscience 111, 799 (2002).
5. P. H. Seeburg, Trends Neurosci. 16, 359 (1993).
6. R. H. Scannevin, R. L. Huganir, Nature Rev. Neurosci. 1, 133 (2000).
7. M. Sheng, S. H. Lee, Cell 105, 825 (2001).
8. S. Tomita, R. A. Nicoll, D. S. Bredt, J. Cell Biol. 153, F19 (2001).
9. R. Malinow, R. C. Malenka, Annu. Rev. Neurosci. 25, 103 (2002).
10. M. F. Barry, E. B. Ziff, Curr. Opin. Neurobiol. 12, 279 (2002).
11. M. Hollmann, S. Heinemann, Annu. Rev. Neurosci. 17, 31 (1994).
12. S. Shi, Y. Hayashi, J. A. Esteban, R. Malinow, Cell 105, 331 (2001).
13. M. Passafaro, V. Piech, M. Sheng, Nature Neurosci. 4, 917 (2001).
14. J. J. Zhu, Y. Qin, M. Zhao, L. Van Aelst, R. Malinow, Cell 110, 443 (2002).
15. R. Malinow et al., in Imaging Living Neurons, R. Yuste, F. Lanni, A. Konnerth, Eds. (Cold Spring Harbor Press, Cold Spring Harbor, NY, 1999), p. 58.1.
16. I. Frolov et al., Proc. Natl. Acad. Sci. U.S.A. 93, 11371 (1996).
17. B. E. Chen et al., Learn. Mem. 7, 433 (2000).
18. K. D. Micheva, C. Beaulieu, J. Comp. Neurol. 373, 340 (1996).
19. E. A. Stem, M. Maravall, K. Svoboda, Neuron 31, 305 (2001).
20. G. T. Finnerty, L. S. Roberts, B. W. Connors, Nature 400, 367 (1999).
21. X. Li, S. Glazewski, X. Lin, R. Elde, K. Fox, J. Comp. Neurol. 357, 465 (1995).
22. See supporting data on Science Online.
23. Y. Hayashi et al., Science 287, 2262 (2000).
24. J. J. Zhu, J. A. Esteban, Y. Hayashi, R. Malinow, Nature Neurosci. 3, 1098 (2000).
25. D. Durham, T. A. Woolsey, J. Comp. Neurol. 223, 424 (1984).
26. The increase in rectification in neurons expressing homomeric GluR1 (a factor of ∼1.3) is considerably smaller than the reduction by GluR1-ct (a factor of ∼2.5). This is consistent with transient delivery of GluR1-containing receptors with subsequent replacement by GluR2-containing receptors. Alternative explanations, such as the delivery of other long-tailed AMPA-Rs (e.g., GluR4 or GluR2-long) during experience, which may be perturbed by GluR1-ct, are possible.
27. J. Noel et al., Neuron 23, 365 (1999).
28. M. S. Rioult-Pedotti, D. Friedman, J. P. Donoghue, Science 290, 533 (2000).
29. M. T. Rogan, U. V. Staubli, J. E. LeDoux, Nature 390, 604 (1997).
30. D. A. Winfield, Brain Res. 206, 166 (1981).
31. A. M. Vees, K. D. Micheva, C. Beaulieu, L. Descarries, J. Comp. Neurol. 400, 110 (1998).
32. We thank H. Cline for careful reading of an earlier version of this manuscript, members of the Malinow laboratory for helpful discussions, B, Burbach and N. Dawkins for expert technical assistance, and S. Rumpel for generating fig. S1B. Supported by NIH grants NS032827 (R.M.) and NS038259 (K.S.), HHMI (K.S.), the Ale Davis and Maxine Harrison Endowment (R.M.), the Cure Autism Now Foundation (T.T.), the Japan International Science and Technology Exchange Center (T.T.), and the Uehara Foundation (T.T.).