Glutamate receptor antibodies in neurological diseases: Anti-AMPA-GluR3 antibodies, Anti-NMDA-NR1 antibodies, Anti-NMDA-NR2A/B antibodies, Anti-mGluR1 antibodies or Anti-mGluR5 antibodies are present in subpopulations of patients with either: Epilepsy, Encephalitis, Cerebellar Ataxia, Systemic Lupus Erythematosus (SLE) and Neuropsychiatric SLE, Sjogren’s syndrome, Schizophrenia, Mania or Stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor’s expression, impair glutamate-induced signaling and function, activate Blood Brain Barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and Ataxia in animal models, and can be removed or silenced in some patients by immunotherapy

Journal of Neural Transmission

Volumn 121, Issue 8, 2014, Pages 1029-1075

  Levite, Mia ^a,b  

^a ACADEMIC COLLEGE OF TEL AVIV YAFFO   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

AMPA; Anti GluR3 antibodies; Anti glutamate receptor antibodies; Anti NMDA receptor Encephalitis; Anti NR1 antibodies; Anti NR2 antibodies; Autoimmune Epilepsy; Encephalitis; Epilepsy; GluR3; GluR3B; Glutamate; Glutamate receptors; Immunotherapy for Epilepsy; Mania; mGluR1; mGluR5; Neuropsychiatric impairments; Neuropsychiatric lupus; Neuropsychiatric Sjogren s Syndrome; NMDA; NMDA encephalitis; NMDA NR1; NMDA NR2; NMDA NR2A B; Ophelia syndrome; Paraneoplastic cerebellar ataxia; Schizophrenia; Seizures; Stroke; Systemic Lupus Erythematosus (SLE)

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID GLUTAMATE RECEPTOR 3 ANTIBODY; ANTIBODY; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTIBODY; KAINIC ACID; METABOTROPIC GLUTAMATE RECEPTOR 1 ANTIBODY; METABOTROPIC RECEPTOR 5 ANTIBODY; N METHYL DEXTRO ASPARTIC ACID N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A ANTIBODY; N METHYL DEXTRO ASPARTIC ACID N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B ANTIBODY; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1 ANTIBODY; UNCLASSIFIED DRUG; GLUTAMIC ACID;

ARTICLE; ATAXIA; BEHAVIOR DISORDER; BLOOD BRAIN BARRIER; BRAIN DAMAGE; BRAIN REGION; CELL DAMAGE; CEREBELLAR ATAXIA; CEREBROVASCULAR ACCIDENT; COGNITIVE DEFECT; ELECTROPHYSIOLOGY; ENCEPHALITIS; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EPILEPSY; EXCITOTOXICITY; FLOW CYTOMETRY; HUMAN; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOTHERAPY; MANIA; MENTAL DISEASE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; WESTERN BLOTTING; ANIMAL; BRAIN; IMMUNOLOGY; METABOLISM; NERVE CELL; NERVOUS SYSTEM DISEASES; PROCEDURES;

ANIMALS; ANTIBODIES; BRAIN; GLUTAMIC ACID; HUMANS; IMMUNOTHERAPY; NERVOUS SYSTEM DISEASES; NEURONS; RECEPTORS, GLUTAMATE;

EID: 84919688241     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-014-1193-3     Document Type: Article

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