메뉴 건너뛰기




Volumn 16, Issue 1, 2016, Pages 22-34

The role of inflammation in depression: From evolutionary imperative to modern treatment target

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CYTOKINE; INFLAMMASOME; NEUROTRANSMITTER; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS;

EID: 84952342629     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2015.5     Document Type: Review
Times cited : (2428)

References (129)
  • 1
    • 84940447040 scopus 로고    scopus 로고
    • Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990 2013: A systematic analysis for the global burden of disease study 2013
    • Global Burden of Disease Study 2013 Collaborators
    • Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990 2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 386, 743-800 (2015).
    • (2015) Lancet , vol.386 , pp. 743-800
  • 2
    • 33751338530 scopus 로고    scopus 로고
    • Acute and longer-Term outcomes in depressed outpatients requiring one or several treatment steps: A STAR D report
    • Rush A. J., et al. Acute and longer-Term outcomes in depressed outpatients requiring one or several treatment steps: a STAR D report. Am. J. Psychiatry. 163, 1905-1917 (2006).
    • (2006) Am. J. Psychiatry , vol.163 , pp. 1905-1917
    • Rush, A.J.1
  • 3
    • 33749072534 scopus 로고    scopus 로고
    • Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress
    • Pace T. W., et al. Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am. J. Psychiatry. 163, 1630-1633 (2006).
    • (2006) Am. J. Psychiatry , vol.163 , pp. 1630-1633
    • Pace, T.W.1
  • 4
    • 0037452804 scopus 로고    scopus 로고
    • A mechanism converting psychosocial stress into mononuclear cell activation
    • Bierhaus A., et al. A mechanism converting psychosocial stress into mononuclear cell activation. Proc. Natl Acad. Sci. USA. 100, 1920-1925 (2003).
    • (2003) Proc Natl Acad. Sci. USA , vol.100 , pp. 1920-1925
    • Bierhaus, A.1
  • 5
    • 84855998031 scopus 로고    scopus 로고
    • Maintenance of a positive outlook during acute stress protects against pro-inflammatory reactivity and future depressive symptoms
    • Aschbacher K., et al. Maintenance of a positive outlook during acute stress protects against pro-inflammatory reactivity and future depressive symptoms. Brain Behav. Immun. 26, 346-352 (2012).
    • (2012) Brain Behav. Immun , vol.26 , pp. 346-352
    • Aschbacher, K.1
  • 6
    • 84871275831 scopus 로고    scopus 로고
    • The evolutionary significance of depression in Pathogen Host Defense (PATHOS D
    • Raison C. L., & Miller A. H. The evolutionary significance of depression in Pathogen Host Defense (PATHOS D). Mol. Psychiatry. 18, 15-37 (2013).
    • (2013) Mol. Psychiatry , vol.18 , pp. 15-37
    • Raison, C.L.1    Miller, A.H.2
  • 7
    • 0036773951 scopus 로고    scopus 로고
    • Toward a revised evolutionary adaptationist analysis of depression: The social navigation hypothesis
    • Watson P. J., & Andrews P. W. Toward a revised evolutionary adaptationist analysis of depression: the social navigation hypothesis. J. Affect. Disord. 72, 1-14 (2002).
    • (2002) J. Affect. Disord , vol.72 , pp. 1-14
    • Watson, P.J.1    Andrews, P.W.2
  • 8
    • 68949125410 scopus 로고    scopus 로고
    • An evolutionary hypothesis of depression and its symptoms, adaptive value, and risk factors
    • Kinney D. K., & Tanaka M. An evolutionary hypothesis of depression and its symptoms, adaptive value, and risk factors. J. Nerv. Ment. Dis. 197, 561-567 (2009).
    • (2009) J. Nerv Ment. Dis , vol.197 , pp. 561-567
    • Kinney, D.K.1    Tanaka, M.2
  • 9
    • 84922642868 scopus 로고    scopus 로고
    • From stress to inflammation and major depressive disorder: A social signal transduction theory of depression
    • Slavich G. M., & Irwin M. R. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol. Bull. 140, 774-815 (2014).
    • (2014) Psychol. Bull , vol.140 , pp. 774-815
    • Slavich, G.M.1    Irwin, M.R.2
  • 10
    • 67650458489 scopus 로고    scopus 로고
    • Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health Surveys
    • Seedat S., et al. Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health Surveys. Arch. Gen. Psychiatry. 66, 785-795 (2009).
    • (2009) Arch. Gen. Psychiatry , vol.66 , pp. 785-795
    • Seedat, S.1
  • 11
    • 84939977643 scopus 로고    scopus 로고
    • Sex differences in depressive and socioemotional responses to an inflammatory challenge: Implications for sex differences in depression
    • Moieni M., et al. Sex differences in depressive and socioemotional responses to an inflammatory challenge: implications for sex differences in depression. Neuropsychopharmacology. 40, 1709-1716 (2015).
    • (2015) Neuropsychopharmacology , vol.40 , pp. 1709-1716
    • Moieni, M.1
  • 12
    • 84865801719 scopus 로고    scopus 로고
    • Interferon-induced depression in chronic hepatitis C: A systematic review and meta-Analysis
    • Udina M., et al. Interferon-induced depression in chronic hepatitis C: a systematic review and meta-Analysis. J. Clin. Psychiatry. 73, 1128-1138 (2012).
    • (2012) J. Clin. Psychiatry , vol.73 , pp. 1128-1138
    • Udina, M.1
  • 13
    • 78649955466 scopus 로고    scopus 로고
    • Inflammation, sanitation, and consternation: Loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression
    • Raison C. L., Lowry C. A., & Rook G. A. Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression. Arch. Gen. Psychiatry. 67, 1211-1224 (2010).
    • (2010) Arch. Gen. Psychiatry , vol.67 , pp. 1211-1224
    • Raison, C.L.1    Lowry, C.A.2    Rook, G.A.3
  • 14
    • 84937639025 scopus 로고    scopus 로고
    • Hygiene and other early childhood influences on the subsequent function of the immune system
    • Rook G. A., Lowry C. A., & Raison C. L. Hygiene and other early childhood influences on the subsequent function of the immune system. Brain Res. 1617, 47-62 (2015).
    • (2015) Brain Res , vol.1617 , pp. 47-62
    • Rook, G.A.1    Lowry, C.A.2    Raison, C.L.3
  • 15
    • 0033669579 scopus 로고    scopus 로고
    • Illness, cytokines, and depression
    • Yirmiya R., et al. Illness, cytokines, and depression. Ann. NY Acad. Sci. 917, 478-487 (2000).
    • (2000) Ann. NY Acad. Sci , vol.917 , pp. 478-487
    • Yirmiya, R.1
  • 16
    • 63449122724 scopus 로고    scopus 로고
    • Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression
    • Miller A. H., Maletic V., & Raison C. L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry. 65, 732-741 (2009).
    • (2009) Biol. Psychiatry , vol.65 , pp. 732-741
    • Miller, A.H.1    Maletic, V.2    Raison, C.L.3
  • 17
    • 0033282727 scopus 로고    scopus 로고
    • Major depression and activation of the inflammatory response system
    • Maes M. Major depression and activation of the inflammatory response system. Adv. Exp. Med. Biol. 461, 25-46 (1999).
    • (1999) Adv. Exp. Med. Biol , vol.461 , pp. 25-46
    • Maes, M.1
  • 18
    • 84903769339 scopus 로고    scopus 로고
    • Increased M1/decreased M2 signature and signs of Th1/Th2 shift in chronic patients with bipolar disorder, but not in those with schizophrenia
    • Brambilla P., et al. Increased M1/decreased M2 signature and signs of Th1/Th2 shift in chronic patients with bipolar disorder, but not in those with schizophrenia. Transl Psychiatry 4, e406 (2014).
    • (2014) Transl Psychiatry , vol.4 , pp. e406
    • Brambilla, P.1
  • 19
    • 84926431712 scopus 로고    scopus 로고
    • Enrichment pathway analysis the inflammatory genetic background in bipolar disorder
    • Drago A., Crisafulli C., Calabro M., & Serretti A. Enrichment pathway analysis. The inflammatory genetic background in bipolar disorder. J. Affect Disord. 179, 88-94 (2015).
    • (2015) J. Affect Disord , vol.179 , pp. 88-94
    • Drago, A.1    Crisafulli, C.2    Calabro, M.3    Serretti, A.4
  • 20
    • 84927176211 scopus 로고    scopus 로고
    • Type i interferon signaling genes in recurrent major depression: Increased expression detected by whole-blood RNA sequencing
    • Mostafavi S., et al. Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing. Mol. Psychiatry 19,1267-1274 (2013).
    • (2013) Mol. Psychiatry , vol.19 , pp. 1267-1274
    • Mostafavi, S.1
  • 21
    • 0028796205 scopus 로고
    • Evidence for an immune response in major depression: A review and hypothesis
    • Maes M. Evidence for an immune response in major depression: a review and hypothesis. Prog. Neuropsychopharmacol. Biol. Psychiatry. 19, 11-38 (1995).
    • (1995) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.19 , pp. 11-38
    • Maes, M.1
  • 22
    • 84878117912 scopus 로고    scopus 로고
    • The role of immune genes in the association between depression and inflammation: A review of recent clinical studies
    • Bufalino C., Hepgul N., Aguglia E., & Pariante C. M. The role of immune genes in the association between depression and inflammation: a review of recent clinical studies. Brain Behav. Immun. 31, 31-47 (2012).
    • (2012) Brain Behav. Immun , vol.31 , pp. 31-47
    • Bufalino, C.1    Hepgul, N.2    Aguglia, E.3    Pariante, C.M.4
  • 23
    • 0036199336 scopus 로고    scopus 로고
    • Neurobehavioral effects of interferon-α in cancer patients: Phenomenology and paroxetine responsiveness of symptom dimensions
    • Capuron L., et al. Neurobehavioral effects of interferon-α in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology. 26, 643-652 (2002).
    • (2002) Neuropsychopharmacology , vol.26 , pp. 643-652
    • Capuron, L.1
  • 24
    • 0035021538 scopus 로고    scopus 로고
    • Cytokine-Associated emotional and cognitive disturbances in humans
    • Reichenberg A., et al. Cytokine-Associated emotional and cognitive disturbances in humans. Arch. Gen. Psychiatry. 58, 445-452 (2001).
    • (2001) Arch. Gen. Psychiatry , vol.58 , pp. 445-452
    • Reichenberg, A.1
  • 25
    • 0036157089 scopus 로고    scopus 로고
    • Increased depressive ratings in patients with hepatitis C receiving interferon-α- based immunotherapy are related to interferon-α- induced changes in the serotonergic system
    • Bonaccorso S., et al. Increased depressive ratings in patients with hepatitis C receiving interferon-α- based immunotherapy are related to interferon-α- induced changes in the serotonergic system. J. Clin. Psychopharmacol. 22, 86-90 (2002).
    • (2002) J. Clin. Psychopharmacol , vol.22 , pp. 86-90
    • Bonaccorso, S.1
  • 26
    • 68049131222 scopus 로고    scopus 로고
    • Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity
    • Harrison N. A., et al. Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biol. Psychiatry. 66, 407-414 (2009).
    • (2009) Biol. Psychiatry , vol.66 , pp. 407-414
    • Harrison, N.A.1
  • 27
    • 29844440963 scopus 로고    scopus 로고
    • Etanercept and clinical outcomes, fatigue, and depression in psoriasis: Double-blind placebo-controlled randomised phase III trial
    • Tyring S., et al. Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial. Lancet. 367, 29-35 (2006).
    • (2006) Lancet , vol.367 , pp. 29-35
    • Tyring, S.1
  • 28
    • 84937973093 scopus 로고    scopus 로고
    • Tumour necrosis factor-α inhibitor therapy in chronic physical illness: A systematic review and meta-Analysis of the effect on depression and anxiety
    • Abbott R., et al. Tumour necrosis factor-α inhibitor therapy in chronic physical illness: a systematic review and meta-Analysis of the effect on depression and anxiety. J. Psychosom. Res. 79, 175-84 (2015).
    • (2015) J. Psychosom. Res , vol.79 , pp. 175-184
    • Abbott, R.1
  • 29
    • 84915812914 scopus 로고    scopus 로고
    • Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: A systematic review and meta-Analysis of randomized clinical trials
    • Kohler O., et al. Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-Analysis of randomized clinical trials. JAMA Psychiatry. 71, 1381-1391 (2014).
    • (2014) JAMA Psychiatry , vol.71 , pp. 1381-1391
    • Kohler, O.1
  • 30
    • 84871986003 scopus 로고    scopus 로고
    • A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: The role of baseline inflammatory biomarkers
    • Raison C. L., et al. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry 70 31-41 (2013).
    • (2013) JAMA Psychiatry , vol.70 , pp. 31-41
    • Raison, C.L.1
  • 31
    • 84931060145 scopus 로고    scopus 로고
    • Are anti-inflammatory therapies viable treatments for psychiatric disorders?: Where the rubber meets the road
    • Miller A. H., & Raison C. L. Are anti-inflammatory therapies viable treatments for psychiatric disorders?: where the rubber meets the road. JAMA Psychiatry. 72, 527-528 (2015).
    • (2015) JAMA Psychiatry , vol.72 , pp. 527-528
    • Miller, A.H.1    Raison, C.L.2
  • 32
    • 84961290737 scopus 로고    scopus 로고
    • Association of CRP genetic variation and CRP level with elevated PTSD symptoms and physiological responses in a civilian population with high levels of trauma
    • Michopoulos V., et al. Association of CRP genetic variation and CRP level with elevated PTSD symptoms and physiological responses in a civilian population with high levels of trauma. Am. J. Psychiatry. 172, 353-362 (2015).
    • (2015) Am. J. Psychiatry , vol.172 , pp. 353-362
    • Michopoulos, V.1
  • 33
    • 84942617251 scopus 로고    scopus 로고
    • C reactive protein is increased in schizophrenia but is not altered by antipsychotics: Meta-Analysis and implications
    • Fernandes B. S., et al. C reactive protein is increased in schizophrenia but is not altered by antipsychotics: meta-Analysis and implications. Mol. Psychiatry http://dx.doi.org/10.1038/mp.2015.87 (2015).
    • (2015) Mol Psychiatry
    • Fernandes, B.S.1
  • 34
    • 84861683430 scopus 로고    scopus 로고
    • Research Domain Criteria: Cognitive systems, neural circuits, and dimensions of behavior
    • Morris S. E., & Cuthbert B. N. Research Domain Criteria: cognitive systems, neural circuits, and dimensions of behavior. Dialogues Clin. Neurosci. 14, 29-37 (2012).
    • (2012) Dialogues Clin. Neurosci , vol.14 , pp. 29-37
    • Morris, S.E.1    Cuthbert, B.N.2
  • 35
    • 84876079221 scopus 로고    scopus 로고
    • Cytokine targets in the brain: Impact on neurotransmitters and neurocircuits
    • Miller A. H., Haroon E., Raison C. L., & Felger J. C. Cytokine targets in the brain: impact on neurotransmitters and neurocircuits. Depress. Anxiety. 30, 297-306 (2013).
    • (2013) Depress. Anxiety , vol.30 , pp. 297-306
    • Miller, A.H.1    Haroon, E.2    Raison, C.L.3    Felger, J.C.4
  • 36
    • 84872500205 scopus 로고    scopus 로고
    • Candidate genes expression profile associated with antidepressants response in the GENDEP study: Differentiating between baseline predictors and longitudinal targets
    • Cattaneo A., et al. Candidate genes expression profile associated with antidepressants response in the GENDEP study: differentiating between baseline predictors and longitudinal targets. Neuropsychopharmacology. 38, 377-385 (2013).
    • (2013) Neuropsychopharmacology , vol.38 , pp. 377-385
    • Cattaneo, A.1
  • 37
    • 84924271594 scopus 로고    scopus 로고
    • Low-grade inflammation differentiates between symptoms of apathy and depression in community-dwelling older individuals
    • Eurelings L. S., Richard E., Eikelenboom P., van Gool W. A., & Moll van Charante E. P. Low-grade inflammation differentiates between symptoms of apathy and depression in community-dwelling older individuals. Int. Psychogeriatr. 27, 639-647 (2015).
    • (2015) Int. Psychogeriatr , vol.27 , pp. 639-647
    • Eurelings, L.S.1    Richard, E.2    Eikelenboom, P.3    Van Gool, W.A.4    Moll Van Charante, E.P.5
  • 38
    • 0037469232 scopus 로고    scopus 로고
    • Markers of inflammation and cardiovascular disease: Application to clinical and public health practice: A statement for healthcare professionals from the centers for disease control and prevention and the American Heart Association
    • Pearson T. A., et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 107, 499-511 (2003).
    • (2003) Circulation , vol.107 , pp. 499-511
    • Pearson, T.A.1
  • 39
    • 80052091705 scopus 로고    scopus 로고
    • Reciprocal regulation of the neural and innate immune systems
    • Irwin M. R., & Cole S. W. Reciprocal regulation of the neural and innate immune systems. Nat. Rev. Immunol. 11, 625-632 (2011).
    • (2011) Nat. Rev. Immunol , vol.11 , pp. 625-632
    • Irwin, M.R.1    Cole, S.W.2
  • 40
    • 84878124765 scopus 로고    scopus 로고
    • The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses
    • Iwata M., Ota K. T., & Duman R. S. The inflammasome: pathways linking psychological stress, depression, and systemic illnesses. Brain Behav. Immun. 31, 105-114 (2013).
    • (2013) Brain Behav. Immun , vol.31 , pp. 105-114
    • Iwata, M.1    Ota, K.T.2    Duman, R.S.3
  • 42
    • 84870726877 scopus 로고    scopus 로고
    • Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasome
    • Fleshner M. Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasome. Brain Behav. Immun. 27, 1-7 (2013).
    • (2013) Brain Behav. Immun , vol.27 , pp. 1-7
    • Fleshner, M.1
  • 43
    • 84891826730 scopus 로고    scopus 로고
    • Adrenergic and glucocorticoid modulation of the sterile inflammatory response
    • Cox S. S., et al. Adrenergic and glucocorticoid modulation of the sterile inflammatory response. Brain Behav. Immun. 36, 183-192 (2014).
    • (2014) Brain Behav. Immun , vol.36 , pp. 183-192
    • Cox, S.S.1
  • 44
    • 84924052001 scopus 로고    scopus 로고
    • Microglial NLRP3 inflammasome activation mediates IL 1β related inflammation in prefrontal cortex of depressive rats
    • Pan Y., Chen X. Y., Zhang Q. Y., & Kong L. D. Microglial NLRP3 inflammasome activation mediates IL 1β related inflammation in prefrontal cortex of depressive rats. Brain Behav. Immun. 41, 90-100 (2014).
    • (2014) Brain Behav. Immun , vol.41 , pp. 90-100
    • Pan, Y.1    Chen, X.Y.2    Zhang, Q.Y.3    Kong, L.D.4
  • 45
    • 84931266463 scopus 로고    scopus 로고
    • NLRP3 inflammasome mediates chronic mild stress-induced depression in mice via neuroinflammation
    • Zhang Y., et al. NLRP3 inflammasome mediates chronic mild stress-induced depression in mice via neuroinflammation. Int. J. Neuropsychopharmacol. 18, pii: pyv006 (2015).
    • (2015) Int. J. Neuropsychopharmacol , vol.18 , pp. pyv006
    • Zhang, Y.1
  • 46
    • 84930088053 scopus 로고    scopus 로고
    • NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells
    • Paugh S. W., et al. NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells. Nat. Genet. 47, 607-614 (2015).
    • (2015) Nat. Genet , vol.47 , pp. 607-614
    • Paugh, S.W.1
  • 47
    • 26844433194 scopus 로고    scopus 로고
    • Antiinflammatory action of glucocorticoidsnew mechanisms for old drugs
    • Rhen T., & Cidlowski J. A. Antiinflammatory action of glucocorticoidsnew mechanisms for old drugs. N. Engl. J. Med. 353, 1711-1723 (2005).
    • (2005) N. Engl. J. Med , vol.353 , pp. 1711-1723
    • Rhen, T.1    Cidlowski, J.A.2
  • 48
    • 0442272538 scopus 로고    scopus 로고
    • When not enough is too much: The role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
    • Raison C. L., & Miller A. H. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am. J. Psychiatry. 160, 1554-1565 (2003).
    • (2003) Am. J. Psychiatry , vol.160 , pp. 1554-1565
    • Raison, C.L.1    Miller, A.H.2
  • 49
    • 33845291521 scopus 로고    scopus 로고
    • Cytokine-effects on glucocorticoid receptor function: Relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression
    • Pace T. W., Hu F., & Miller A. H. Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. Brain Behav. Immun. 21, 9-19 (2007).
    • (2007) Brain Behav. Immun , vol.21 , pp. 9-19
    • Pace, T.W.1    Hu, F.2    Miller, A.H.3
  • 50
    • 84891829365 scopus 로고    scopus 로고
    • NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder
    • Alcocer-Gomez E., et al. NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder. Brain Behav. Immun. 36, 111-117 (2014).
    • (2014) Brain Behav. Immun , vol.36 , pp. 111-117
    • Alcocer-Gomez, E.1
  • 51
    • 84938741413 scopus 로고    scopus 로고
    • Damage-Associated molecular patterns and immune activation in bipolar disorder
    • Stertz L., et al. Damage-Associated molecular patterns and immune activation in bipolar disorder. Acta Psychiatr. Scand. 132, 211-217 (2015).
    • (2015) Acta Psychiatr. Scand , vol.132 , pp. 211-217
    • Stertz, L.1
  • 52
    • 84878128205 scopus 로고    scopus 로고
    • Dysregulated relationship of inflammation and oxidative stress in major depression
    • Rawdin B. J., et al. Dysregulated relationship of inflammation and oxidative stress in major depression. Brain Behav. Immun. 31, 143-152 (2013).
    • (2013) Brain Behav. Immun , vol.31 , pp. 143-152
    • Rawdin, B.J.1
  • 53
    • 79954568978 scopus 로고    scopus 로고
    • A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness
    • Maes M., Galecki P., Chang Y. S., & Berk M. A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. Prog. Neuropsychopharmacol. Biol. Psychiatry. 35, 676-692 (2011).
    • (2011) Prog Neuropsychopharmacol. Biol. Psychiatry , vol.35 , pp. 676-692
    • Maes, M.1    Galecki, P.2    Chang, Y.S.3    Berk, M.4
  • 55
    • 84870915821 scopus 로고    scopus 로고
    • Commensal bacteria and MAMPs are necessary for stress-induced increases in IL 1β and IL 18 but not IL 6, IL 10 or MCP 1
    • Maslanik T., et al. Commensal bacteria and MAMPs are necessary for stress-induced increases in IL 1β and IL 18 but not IL 6, IL 10 or MCP 1. PLoS ONE 7, e50636 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e50636
    • Maslanik, T.1
  • 56
    • 79151470955 scopus 로고    scopus 로고
    • Stress at the intestinal surface: Catecholamines and mucosa-bacteria interactions
    • Lyte M., Vulchanova L., & Brown D. R. Stress at the intestinal surface: catecholamines and mucosa-bacteria interactions. Cell Tissue Res. 343, 23-32 (2011).
    • (2011) Cell Tissue Res , vol.343 , pp. 23-32
    • Lyte, M.1    Vulchanova, L.2    Brown, D.R.3
  • 57
    • 77950022786 scopus 로고    scopus 로고
    • Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients
    • Rao J. S., Harry G. J., Rapoport S. I., & Kim H. W. Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol. Psychiatry. 15, 384-392 (2010).
    • (2010) Mol. Psychiatry , vol.15 , pp. 384-392
    • Rao, J.S.1    Harry, G.J.2    Rapoport, S.I.3    Kim, H.W.4
  • 58
    • 35848950202 scopus 로고    scopus 로고
    • Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide
    • Steiner J., et al. Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide. J. Psychiatr. Res. 42, 151-157 (2008).
    • (2008) J. Psychiatr. Res , vol.42 , pp. 151-157
    • Steiner, J.1
  • 59
    • 84908617290 scopus 로고    scopus 로고
    • Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides
    • Torres-Platas S. G., Cruceanu C., Chen G. G., Turecki G., & Mechawar N. Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides. Brain Behav. Immun. 42, 50-59 (2014).
    • (2014) Brain Behav. Immun , vol.42 , pp. 50-59
    • Torres-Platas, S.G.1    Cruceanu, C.2    Chen, G.G.3    Turecki, G.4    Mechawar, N.5
  • 60
    • 84924696740 scopus 로고    scopus 로고
    • Astrocytic abnormalities and global DNA methylation patterns in depression and suicide
    • Nagy C., et al. Astrocytic abnormalities and global DNA methylation patterns in depression and suicide. Mol. Psychiatry. 20, 320-328 (2015).
    • (2015) Mol. Psychiatry , vol.20 , pp. 320-328
    • Nagy, C.1
  • 61
    • 84925357658 scopus 로고    scopus 로고
    • Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes
    • Setiawan E., et al. Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes. JAMA Psychiatry. 72, 268-275 (2015).
    • (2015) JAMA Psychiatry , vol.72 , pp. 268-275
    • Setiawan, E.1
  • 62
    • 84883822520 scopus 로고    scopus 로고
    • The neuroinflammation marker translocator protein is not elevated in individuals with mild to moderate depression: A [11C]PBR28 PET study
    • Hannestad J., et al. The neuroinflammation marker translocator protein is not elevated in individuals with mild to moderate depression: a [11C]PBR28 PET study. Brain Behav. Immun. 33, 131-138 (2013).
    • (2013) Brain Behav. Immun , vol.33 , pp. 131-138
    • Hannestad, J.1
  • 63
    • 84943405909 scopus 로고    scopus 로고
    • Imaging robust microglial activation after lipopolysaccharide administration in humans with PET
    • Sandiego C. M., et al. Imaging robust microglial activation after lipopolysaccharide administration in humans with PET. Proc. Natl Acad. Sci. USA. 112, 12468-12473 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 12468-12473
    • Sandiego, C.M.1
  • 64
    • 34347268434 scopus 로고    scopus 로고
    • Brain-immune communication pathways
    • Quan N., & Banks W. A. Brain-immune communication pathways. Brain Behav. Immun. 21, 727-735 (2007).
    • (2007) Brain Behav. Immun , vol.21 , pp. 727-735
    • Quan, N.1    Banks, W.A.2
  • 65
    • 60849135712 scopus 로고    scopus 로고
    • Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factor-α signaling during peripheral organ inflammation
    • DMello C., Le T., & Swain M. G. Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factor-α signaling during peripheral organ inflammation. J. Neurosci. 29, 2089-2102 (2009).
    • (2009) J. Neurosci , vol.29 , pp. 2089-2102
    • DMello, C.1    Le, T.2    Swain, M.G.3
  • 66
    • 84930435742 scopus 로고    scopus 로고
    • Astrocytes are primed by chronic neurodegeneration to produce exaggerated chemokine and cell infiltration responses to acute stimulation with the cytokines IL 1β and TNF-α
    • Hennessy E., Griffin E. W., & Cunningham C. Astrocytes are primed by chronic neurodegeneration to produce exaggerated chemokine and cell infiltration responses to acute stimulation with the cytokines IL 1β and TNF-α. J. Neurosci. 35, 8411-8422 (2015).
    • (2015) J. Neurosci , vol.35 , pp. 8411-8422
    • Hennessy, E.1    Griffin, E.W.2    Cunningham, C.3
  • 67
    • 79955780432 scopus 로고    scopus 로고
    • Β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat
    • Wohleb E. S., et al. β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. J. Neurosci. 31 6277-6288 (2011).
    • (2011) J. Neurosci , vol.31 , pp. 6277-6288
    • Wohleb, E.S.1
  • 68
    • 84882596593 scopus 로고    scopus 로고
    • Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior
    • Wohleb E. S., Powell N. D., Godbout J. P., & Sheridan J. F. Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. J. Neurosci. 33, 13820-13833 (2013).
    • (2013) J. Neurosci , vol.33 , pp. 13820-13833
    • Wohleb, E.S.1    Powell, N.D.2    Godbout, J.P.3    Sheridan, J.F.4
  • 69
    • 84875277496 scopus 로고    scopus 로고
    • Antidepressant effects of TNF-α blockade in an animal model of depression
    • Krugel U., Fischer J., Radicke S., Sack U., & Himmerich H. Antidepressant effects of TNF-α blockade in an animal model of depression. J. Psychiatr. Res. 47, 611-616 (2013).
    • (2013) J. Psychiatr. Res , vol.47 , pp. 611-616
    • Krugel, U.1    Fischer, J.2    Radicke, S.3    Sack, U.4    Himmerich, H.5
  • 70
    • 79959260432 scopus 로고    scopus 로고
    • Baseline predictors of response and discontinuation of tumor necrosis factor-α blocking therapy in ankylosing spondylitis: A prospective longitudinal observational cohort study
    • Arends S., et al. Baseline predictors of response and discontinuation of tumor necrosis factor-α blocking therapy in ankylosing spondylitis: a prospective longitudinal observational cohort study. Arthritis Res. Ther. 13, R94 (2011).
    • (2011) Arthritis Res. Ther , vol.13 , pp. R94
    • Arends, S.1
  • 72
    • 78149466027 scopus 로고    scopus 로고
    • Interleukin 1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters
    • Zhu C. B., et al. Interleukin 1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters. Neuropsychopharmacology. 35, 2510-2520 (2010).
    • (2010) Neuropsychopharmacology , vol.35 , pp. 2510-2520
    • Zhu, C.B.1
  • 73
    • 52449126348 scopus 로고    scopus 로고
    • Chronic immune stimulation correlates with reduced phenylalanine turnover
    • Neurauter G., et al. Chronic immune stimulation correlates with reduced phenylalanine turnover. Curr. Drug Metab. 9, 622-627 (2008).
    • (2008) Curr. Drug Metab , vol.9 , pp. 622-627
    • Neurauter, G.1
  • 74
    • 84878160653 scopus 로고    scopus 로고
    • Tyrosine metabolism during interferon-α administration: Association with fatigue and CSF dopamine concentrations
    • Felger J. C., et al. Tyrosine metabolism during interferon-α administration: association with fatigue and CSF dopamine concentrations. Brain Behav. Immun. 31, 153-160 (2013).
    • (2013) Brain Behav. Immun , vol.31 , pp. 153-160
    • Felger, J.C.1
  • 75
    • 79954604454 scopus 로고    scopus 로고
    • The new 5 HT hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3 dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
    • Maes M., Leonard B. E., Myint A. M., Kubera M., & Verkerk R. The new 5 HT hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3 dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry. 35, 702-721 (2011).
    • (2011) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.35 , pp. 702-721
    • Maes, M.1    Leonard, B.E.2    Myint, A.M.3    Kubera, M.4    Verkerk, R.5
  • 76
    • 77950022119 scopus 로고    scopus 로고
    • CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: Relationship to CNS immune responses and depression
    • Raison C. L., et al. CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression. Mol. Psychiatry. 15, 393-403 (2010).
    • (2010) Mol. Psychiatry , vol.15 , pp. 393-403
    • Raison, C.L.1
  • 77
    • 81155157520 scopus 로고    scopus 로고
    • Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?
    • Steiner J., et al. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?. J. Neuroinflamm. 8, 94 (2011).
    • (2011) J. Neuroinflamm , vol.8 , pp. 94
    • Steiner, J.1
  • 78
    • 0036128148 scopus 로고    scopus 로고
    • Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes
    • Tavares R. G., et al. Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes. Neurochem. Int. 40, 621-627 (2002).
    • (2002) Neurochem. Int , vol.40 , pp. 621-627
    • Tavares, R.G.1
  • 79
    • 34547435817 scopus 로고    scopus 로고
    • Neuroinflammation and regulation of glial glutamate uptake in neurological disorders
    • Tilleux S., & Hermans E. Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J. Neurosci. Res. 85, 2059-2070 (2007).
    • (2007) J. Neurosci. Res , vol.85 , pp. 2059-2070
    • Tilleux, S.1    Hermans, E.2
  • 80
    • 0036241207 scopus 로고    scopus 로고
    • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
    • Hardingham G. E., Fukunaga Y., & Bading H. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat. Neurosci. 5, 405-414 (2002).
    • (2002) Nat. Neurosci , vol.5 , pp. 405-414
    • Hardingham, G.E.1    Fukunaga, Y.2    Bading, H.3
  • 81
    • 77249129746 scopus 로고    scopus 로고
    • Nuclear factor ?B is a critical mediator of stress-impaired neurogenesis and depressive behavior
    • Koo J. W., Russo S. J., Ferguson D., Nestler N. J., & Duman R. S. Nuclear factor ?B is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc. Natl Acad. Sci. USA. 107, 2669-2674 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 2669-2674
    • Koo, J.W.1    Russo, S.J.2    Ferguson, D.3    Nestler, N.J.4    Duman, R.S.5
  • 82
    • 45549084470 scopus 로고    scopus 로고
    • Brain interleukin 1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression
    • Goshen I., et al. Brain interleukin 1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol. Psychiatry. 13, 717-728 (2008).
    • (2008) Mol. Psychiatry , vol.13 , pp. 717-728
    • Goshen, I.1
  • 83
    • 84900548523 scopus 로고    scopus 로고
    • IFN-α-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy
    • Haroon E., et al. IFN-α-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy. Neuropsychopharmacology. 39, 1777-1785 (2014).
    • (2014) Neuropsychopharmacology , vol.39 , pp. 1777-1785
    • Haroon, E.1
  • 84
    • 84954540029 scopus 로고    scopus 로고
    • Conceptual convergence:increased inflammation is associated with increased basal ganglia glutamate in patients with major depression
    • Haroon E., et al. Conceptual convergence:increased inflammation is associated with increased basal ganglia glutamate in patients with major depression. Mol. Psychiatry http://dx.doi.org/10.1038/.mp.2015.206 (2015).
    • (2015) Mol. Psychiatry
    • Haroon, E.1
  • 85
    • 84880331865 scopus 로고    scopus 로고
    • NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice
    • Walker A. K., et al. NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice. Neuropsychopharmacology. 38, 1609-1616 (2013).
    • (2013) Neuropsychopharmacology , vol.38 , pp. 1609-1616
    • Walker, A.K.1
  • 86
    • 65349135346 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3 dioxygenase activation in mice
    • OConnor J. C., et al. Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3 dioxygenase activation in mice. Mol. Psychiatry. 14, 511-522 (2009).
    • (2009) Mol. Psychiatry , vol.14 , pp. 511-522
    • OConnor, J.C.1
  • 87
    • 33745208951 scopus 로고    scopus 로고
    • A neurotrophic model for stress-related mood disorders
    • Duman R. S., & Monteggia L. M. A neurotrophic model for stress-related mood disorders. Biol. Psychiatry. 59, 1116-1127 (2006).
    • (2006) Biol Psychiatry , vol.59 , pp. 1116-1127
    • Duman, R.S.1    Monteggia, L.M.2
  • 88
    • 84909595107 scopus 로고    scopus 로고
    • Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress
    • Hodes G. E., et al. Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proc. Natl Acad. Sci. USA. 111, 16136-16141 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 16136-16141
    • Hodes, G.E.1
  • 89
    • 84867093483 scopus 로고    scopus 로고
    • Dopaminergic mechanisms of reduced basal ganglia responses to hedonic reward during interferon-α administration
    • Capuron L., et al. Dopaminergic mechanisms of reduced basal ganglia responses to hedonic reward during interferon-α administration. Arch. Gen. Psychiatry. 69, 1044-1053 (2012).
    • (2012) Arch. Gen. Psychiatry , vol.69 , pp. 1044-1053
    • Capuron, L.1
  • 90
    • 77957374545 scopus 로고    scopus 로고
    • Inflammation-induced anhedonia: Endotoxin reduces ventral striatum responses to reward
    • Eisenberger N. I., et al. Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biol. Psychiatry. 68, 748-754 (2010).
    • (2010) Biol. Psychiatry , vol.68 , pp. 748-754
    • Eisenberger, N.I.1
  • 91
    • 84884281797 scopus 로고    scopus 로고
    • Chronic interferon-α decreases dopamine 2 receptor binding and striatal dopamine release in association with anhedonia-like behavior in nonhuman primates
    • Felger J. C., et al. Chronic interferon-α decreases dopamine 2 receptor binding and striatal dopamine release in association with anhedonia-like behavior in nonhuman primates. Neuropsychopharmacology. 38, 2179-2187 (2013).
    • (2013) Neuropsychopharmacology , vol.38 , pp. 2179-2187
    • Felger, J.C.1
  • 92
    • 84955187323 scopus 로고    scopus 로고
    • Acute changes in striatal microstructure predict the development of interferon-α induced fatigue
    • Dowell N. G., et al. Acute changes in striatal microstructure predict the development of interferon-α induced fatigue. Biol. Psychiatry http://dx.doi.org/.10.1016/j.biopsych.2015.05.015 (2015).
    • (2015) Biol. Psychiatry
    • Dowell, N.G.1
  • 93
    • 84925157112 scopus 로고    scopus 로고
    • Effects of inflammation on hippocampus and substantia nigra responses to novelty in healthy human participants
    • Harrison N. A., Cercignani M., Voon V., & Critchley H. D. Effects of inflammation on hippocampus and substantia nigra responses to novelty in healthy human participants. Neuropsychopharmacology. 40, 831-838 (2015).
    • (2015) Neuropsychopharmacology , vol.40 , pp. 831-838
    • Harrison, N.A.1    Cercignani, M.2    Voon, V.3    Critchley, H.D.4
  • 94
    • 84940925027 scopus 로고    scopus 로고
    • A neuro-computational account of how inflammation enhances sensitivity to punishments versus rewards
    • Harrison N. A., et al. A neuro-computational account of how inflammation enhances sensitivity to punishments versus rewards. Biol. Psychiatry http://dx.doi.org/10.1016/j.biopsych.2015.07.018 (2015).
    • (2015) Biol Psychiatry
    • Harrison, N.A.1
  • 95
    • 84946781649 scopus 로고    scopus 로고
    • Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression
    • Felger J. C., et al. Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression. Mol. Psychiatry http://dx.doi.org/10.1038/mp.2015.168 (2015).
    • (2015) Mol. Psychiatry
    • Felger, J.C.1
  • 96
    • 68049127926 scopus 로고    scopus 로고
    • Neural origins of human sickness in interoceptive responses to inflammation
    • Harrison N. A., et al. Neural origins of human sickness in interoceptive responses to inflammation. Biol. Psychiatry. 66, 415-422 (2009).
    • (2009) Biol. Psychiatry , vol.66 , pp. 415-422
    • Harrison, N.A.1
  • 97
    • 77957085425 scopus 로고    scopus 로고
    • Neural sensitivity to social rejection is associated with inflammatory responses to social stress
    • Slavich G. M., Way B. M., Eisenberger N. I., & Taylor S. E. Neural sensitivity to social rejection is associated with inflammatory responses to social stress. Proc. Natl Acad. Sci. USA. 107, 14817-14822 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 14817-14822
    • Slavich, G.M.1    Way, B.M.2    Eisenberger, N.I.3    Taylor, S.E.4
  • 98
    • 3042785850 scopus 로고    scopus 로고
    • Why rejection hurts: A common neural alarm system for physical and social pain
    • Eisenberger N. I., & Lieberman M. D. Why rejection hurts: a common neural alarm system for physical and social pain. Trends Cogn. Sci. 8, 294-300 (2004).
    • (2004) Trends Cogn. Sci , vol.8 , pp. 294-300
    • Eisenberger, N.I.1    Lieberman, M.D.2
  • 99
    • 84919442224 scopus 로고    scopus 로고
    • Greater amygdala activity and dorsomedial prefrontal-Amygdala coupling are associated with enhanced inflammatory responses to stress
    • Muscatell K. A., et al. Greater amygdala activity and dorsomedial prefrontal-Amygdala coupling are associated with enhanced inflammatory responses to stress. Brain Behav. Immun. 43, 46-53 (2015).
    • (2015) Brain Behav. Immun , vol.43 , pp. 46-53
    • Muscatell, K.A.1
  • 100
    • 63249106013 scopus 로고    scopus 로고
    • Associations of C reactive protein and interleukin 6 with cognitive symptoms of depression: 12 year follow up of the Whitehall II study
    • Gimeno D., et al. Associations of C reactive protein and interleukin 6 with cognitive symptoms of depression: 12 year follow up of the Whitehall II study. Psychol. Med. 39, 413-423 (2009).
    • (2009) Psychol. Med , vol.39 , pp. 413-423
    • Gimeno, D.1
  • 101
    • 84938059502 scopus 로고    scopus 로고
    • The longitudinal associations between C reactive protein and depressive symptoms: Evidence from the English Longitudinal Study of Ageing (ELSA
    • Au B., Smith K. J., Gariepy G., & Schmitz N. The longitudinal associations between C reactive protein and depressive symptoms: evidence from the English Longitudinal Study of Ageing (ELSA). Int. J. Geriatr. Psychiatry. 30, 976-984 (2015).
    • (2015) Int. J. Geriatr. Psychiatry , vol.30 , pp. 976-984
    • Au, B.1    Smith, K.J.2    Gariepy, G.3    Schmitz, N.4
  • 102
    • 80052442279 scopus 로고    scopus 로고
    • Depressive symptoms, health behaviors, and subsequent inflammation in patients with coronary heart disease: Prospective findings from the heart and soul study
    • Duivis H. E., et al. Depressive symptoms, health behaviors, and subsequent inflammation in patients with coronary heart disease: prospective findings from the heart and soul study. Am. J. Psychiatry. 168, 913-920 (2011).
    • (2011) Am. J. Psychiatry , vol.168 , pp. 913-920
    • Duivis, H.E.1
  • 103
    • 84930350748 scopus 로고    scopus 로고
    • Childhood trauma and adulthood inflammation: A meta-Analysis of peripheral C reactive protein, interleukin 6 and tumour necrosis factor-α
    • Baumeister D., Akhtar R., Ciufolini S., Pariante C. M., & Mondelli V. Childhood trauma and adulthood inflammation: a meta-Analysis of peripheral C reactive protein, interleukin 6 and tumour necrosis factor-α. Mol. Psychiatry http://dx.doi.org/10.1038/.mp.2015.67 (2015).
    • (2015) Mol. Psychiatry
    • Baumeister, D.1    Akhtar, R.2    Ciufolini, S.3    Pariante, C.M.4    Mondelli, V.5
  • 105
    • 84928823522 scopus 로고    scopus 로고
    • Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1β in youth
    • Tartter M., Hammen C., Bower J. E., Brennan P. A., & Cole S. Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1β in youth. Brain Behav. Immun. 46, 104-111 (2015).
    • (2015) Brain Behav. Immun , vol.46 , pp. 104-111
    • Tartter, M.1    Hammen, C.2    Bower, J.E.3    Brennan, P.A.4    Cole, S.5
  • 106
    • 84871717397 scopus 로고    scopus 로고
    • Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions
    • Klengel T., et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat. Neurosci. 16, 33-41 (2013).
    • (2013) Nat. Neurosci , vol.16 , pp. 33-41
    • Klengel, T.1
  • 107
    • 48149093475 scopus 로고    scopus 로고
    • A functional genomic fingerprint of chronic stress in humans: Blunted glucocorticoid and increased NF ?B signaling
    • Miller G. E., et al. A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF ?B signaling. Biol. Psychiatry. 64, 266-272 (2008).
    • (2008) Biol Psychiatry , vol.64 , pp. 266-272
    • Miller, G.E.1
  • 108
    • 84921900973 scopus 로고    scopus 로고
    • Lymphocytes from chronically stressed mice confer antidepressant-like effects to naive mice
    • Brachman R. A., Lehmann M. L., Maric D., & Herkenham M. Lymphocytes from chronically stressed mice confer antidepressant-like effects to naive mice. J. Neurosci. 35, 1530-1538 (2015).
    • (2015) J. Neurosci , vol.35 , pp. 1530-1538
    • Brachman, R.A.1    Lehmann, M.L.2    Maric, D.3    Herkenham, M.4
  • 109
    • 50249163077 scopus 로고    scopus 로고
    • Reducing post-Traumatic anxiety by immunization
    • Lewitus G. M., Cohen H., & Schwartz M. Reducing post-Traumatic anxiety by immunization. Brain Behav. Immun. 22, 1108-1114 (2008).
    • (2008) Brain Behav. Immun , vol.22 , pp. 1108-1114
    • Lewitus, G.M.1    Cohen, H.2    Schwartz, M.3
  • 110
    • 58349096866 scopus 로고    scopus 로고
    • Vaccination as a novel approach for treating depressive behavior
    • Lewitus G. M., et al. Vaccination as a novel approach for treating depressive behavior. Biol. Psychiatry. 65, 283-288 (2009).
    • (2009) Biol. Psychiatry , vol.65 , pp. 283-288
    • Lewitus, G.M.1
  • 111
    • 77952311924 scopus 로고    scopus 로고
    • Regulation of learning and memory by meningeal immunity: A key role for IL 4
    • Derecki N. C., et al. Regulation of learning and memory by meningeal immunity: a key role for IL 4. J. Exp. Med. 207, 1067-1080 (2010).
    • (2010) J. Exp. Med , vol.207 , pp. 1067-1080
    • Derecki, N.C.1
  • 112
    • 84936871460 scopus 로고    scopus 로고
    • Structural and functional features of central nervous system lymphatic vessels
    • Louveau A., et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 523, 337-341 (2015).
    • (2015) Nature , vol.523 , pp. 337-341
    • Louveau, A.1
  • 113
    • 84864480089 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cell depletion modulates anxiety and depression-like behaviors in mice
    • Kim S. J., et al. CD4+CD25+ regulatory T cell depletion modulates anxiety and depression-like behaviors in mice. PLoS ONE 7, e42054 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e42054
    • Kim, S.J.1
  • 114
    • 80053593864 scopus 로고    scopus 로고
    • Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit
    • Rosas-Ballina M., et al. Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science. 334, 98-101 (2011).
    • (2011) Science , vol.334 , pp. 98-101
    • Rosas-Ballina, M.1
  • 115
    • 0037114798 scopus 로고    scopus 로고
    • Dexamethasone-induced effects on lymphocyte distribution and expression of adhesion molecules in treatment-resistant depression
    • Bauer M. E., et al. Dexamethasone-induced effects on lymphocyte distribution and expression of adhesion molecules in treatment-resistant depression. Psychiatry Res. 113, 1-15 (2002).
    • (2002) Psychiatry Res , vol.113 , pp. 1-15
    • Bauer, M.E.1
  • 116
    • 0842308209 scopus 로고    scopus 로고
    • Interleukin 1α (IL 1α) induced activation of p38 mitogen-Activated protein kinase inhibits glucocorticoid receptor function
    • Wang X., Wu H., & Miller A. H. Interleukin 1α (IL 1α) induced activation of p38 mitogen-Activated protein kinase inhibits glucocorticoid receptor function. Mol. Psychiatry. 9, 65-75 (2004).
    • (2004) Mol. Psychiatry , vol.9 , pp. 65-75
    • Wang, X.1    Wu, H.2    Miller, A.H.3
  • 117
    • 84938747678 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in major depression patients suppress T cell responses through the production of reactive oxygen species
    • Wei J., Zhang M., & Zhou J. Myeloid-derived suppressor cells in major depression patients suppress T cell responses through the production of reactive oxygen species. Psychiatry Res. 228, 695-701 (2015).
    • (2015) Psychiatry Res , vol.228 , pp. 695-701
    • Wei, J.1    Zhang, M.2    Zhou, J.3
  • 118
    • 78650360196 scopus 로고    scopus 로고
    • The inflammasome component NLRP3 impairs antitumor vaccine by enhancing the accumulation of tumor-Associated myeloid-derived suppressor cells
    • van Deventer H. W., et al. The inflammasome component NLRP3 impairs antitumor vaccine by enhancing the accumulation of tumor-Associated myeloid-derived suppressor cells. Cancer Res. 70, 10161-10169 (2010).
    • (2010) Cancer Res , vol.70 , pp. 10161-10169
    • Van Deventer, H.W.1
  • 119
    • 77952287503 scopus 로고    scopus 로고
    • Altered expression of CD4+CD25+ regulatory T cells and its 5 HT1a receptor in patients with major depression disorder
    • Li Y., et al. Altered expression of CD4+CD25+ regulatory T cells and its 5 HT1a receptor in patients with major depression disorder. J. Affect. Disord. 124, 68-75 (2010).
    • (2010) J. Affect. Disord , vol.124 , pp. 68-75
    • Li, Y.1
  • 120
    • 84937126408 scopus 로고    scopus 로고
    • Got worms? Perinatal exposure to helminths prevents persistent immune sensitization and cognitive dysfunction induced by early-life infection
    • Williamson L. L., et al. Got worms?. Perinatal exposure to helminths prevents persistent immune sensitization and cognitive dysfunction induced by early-life infection. Brain Behav. Immun. (2015).
    • (2015) Brain Behav. Immun
    • Williamson, L.L.1
  • 121
    • 84862727180 scopus 로고    scopus 로고
    • Rethinking inflammation: Neural circuits in the regulation of immunity
    • Olofsson P. S., Rosas-Ballina M., Levine Y. A., & Tracey K. J. Rethinking inflammation: neural circuits in the regulation of immunity. Immunol. Rev. 248, 188-204 (2012).
    • (2012) Immunol. Rev , vol.248 , pp. 188-204
    • Olofsson, P.S.1    Rosas-Ballina, M.2    Levine, Y.A.3    Tracey, K.J.4
  • 122
    • 84908132425 scopus 로고    scopus 로고
    • Plasticity of mesenchymal stem cells in immunomodulation: Pathological and therapeutic implications
    • Wang Y., Chen X., Cao W., & Shi Y. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat. Immunol. 15, 1009-1016 (2014).
    • (2014) Nat. Immunol , vol.15 , pp. 1009-1016
    • Wang, Y.1    Chen, X.2    Cao, W.3    Shi, Y.4
  • 123
    • 79959343388 scopus 로고    scopus 로고
    • Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans
    • Warner-Schmidt J. L., Vanover K. E., Chen E. Y., Marshall J. J., & Greengard P. Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proc. Natl Acad. Sci. USA. 108, 9262-9267 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 9262-9267
    • Warner-Schmidt, J.L.1    Vanover, K.E.2    Chen, E.Y.3    Marshall, J.J.4    Greengard, P.5
  • 124
    • 34249864457 scopus 로고    scopus 로고
    • Longevity among hunter-gatherers: A cross-cultural examination
    • Gurven M., & Kaplan H. Longevity among hunter-gatherers: a cross-cultural examination. Popul. Dev. Rev. 33, 321-365 (2007).
    • (2007) Popul. Dev. Rev , vol.33 , pp. 321-365
    • Gurven, M.1    Kaplan, H.2
  • 125
    • 81755177812 scopus 로고    scopus 로고
    • Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution
    • Fumagalli M., et al. Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution. PLoS Genet. 7, e1002355 (2011).
    • (2011) PLoS Genet , vol.7 , pp. e1002355
    • Fumagalli, M.1
  • 126
    • 70450162305 scopus 로고    scopus 로고
    • Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population
    • Kuningas M., et al. Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population. PLoS ONE 4, e7795 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e7795
    • Kuningas, M.1
  • 127
    • 84881234254 scopus 로고    scopus 로고
    • A bad case of the flu?: The comparative phenomenology of depression and somatic illness
    • Ratcliffe M. A bad case of the flu?: the comparative phenomenology of depression and somatic illness. J. Conscious. Studies. 20, 198-218 (2013).
    • (2013) J. Conscious. Studies , vol.20 , pp. 198-218
    • Ratcliffe, M.1
  • 128
    • 84885104129 scopus 로고    scopus 로고
    • Learning and memory and the immune system
    • Marin I., & Kipnis J. Learning and memory and the immune system. Learn. Mem. 20, 601-606 (2013).
    • (2013) Learn. Mem , vol.20 , pp. 601-606
    • Marin, I.1    Kipnis, J.2
  • 129
    • 84878129547 scopus 로고    scopus 로고
    • Transcriptional signatures related to glucose and lipid metabolism predict treatment response to the tumor necrosis factor antagonist infliximab in patients with treatment-resistant depression
    • Mehta D., et al. Transcriptional signatures related to glucose and lipid metabolism predict treatment response to the tumor necrosis factor antagonist infliximab in patients with treatment-resistant depression. Brain Behav. Immun. 31, 205-215 (2013).
    • (2013) Brain Behav. Immun , vol.31 , pp. 205-215
    • Mehta, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.