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Volumn 16, Issue 8, 2015, Pages 469-486

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; COMPLEMENT; COMPLEMENT FACTOR; CYTOKINE; GAMMA INTERFERON; HLA ANTIGEN; IMMUNOSUPPRESSIVE AGENT; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE A; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MATERNAL ANTIBODY; MINOCYCLINE; MYOCYTE ENHANCER FACTOR 2; PLACEBO; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 84937558111     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn3978     Document Type: Review
Times cited : (353)

References (266)
  • 2
    • 85030456408 scopus 로고    scopus 로고
    • Prevalence of autism spectrum disorder among children aged 8 years - Autism and developmental disabilities monitoring network, 11 Sites, United States, 2010
    • Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators & Centers for Disease Control and Prevention (CDC). Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 Sites, United States, 2010. MMWR Surveill. Summ. 63, 1-21 (2014).
    • (2014) MMWR Surveill. Summ. , vol.63 , pp. 1-21
    • Centers for Disease Control and Prevention (CDC)1
  • 3
    • 67349152455 scopus 로고    scopus 로고
    • The rise in autism and the role of age at diagnosis
    • Hertz-Picciotto, I. & Delwiche, L. The rise in autism and the role of age at diagnosis. Epidemiology 20, 84-90 (2009).
    • (2009) Epidemiology , vol.20 , pp. 84-90
    • Hertz-Picciotto, I.1    Delwiche, L.2
  • 4
    • 80051944739 scopus 로고    scopus 로고
    • Genetic heritability and shared environmental factors among twin pairs with autism
    • Hallmayer, J. et al. Genetic heritability and shared environmental factors among twin pairs with autism. Arch. Gen. Psychiatry 68, 1095-1102 (2011).
    • (2011) Arch. Gen. Psychiatry , vol.68 , pp. 1095-1102
    • Hallmayer, J.1
  • 5
    • 70349753233 scopus 로고    scopus 로고
    • Characteristics and concordance of autism spectrum disorders among 277 twin pairs
    • Rosenberg, R. E. et al. Characteristics and concordance of autism spectrum disorders among 277 twin pairs. Arch. Pediatr. Adolesc. Med. 163, 907-914 (2009).
    • (2009) Arch. Pediatr. Adolesc. Med. , vol.163 , pp. 907-914
    • Rosenberg, R.E.1
  • 6
    • 44649103238 scopus 로고    scopus 로고
    • Immunologic and neurodevelopmental susceptibilities of autism
    • Pessah, I. N. et al. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology 29, 532-545 (2008).
    • (2008) Neurotoxicology , vol.29 , pp. 532-545
    • Pessah, I.N.1
  • 7
    • 77649139342 scopus 로고    scopus 로고
    • Early-life programming of later-life brain and behavior: A critical role for the immune system
    • Bilbo, S. D. & Schwarz, J. M. Early-life programming of later-life brain and behavior: a critical role for the immune system. Front. Behav. Neurosci. 3, 14 (2009).
    • (2009) Front. Behav. Neurosci. , vol.3 , pp. 14
    • Bilbo, S.D.1    Schwarz, J.M.2
  • 8
    • 0034252308 scopus 로고    scopus 로고
    • The most elegant immunological experiment of the XIX century
    • Silverstein, A. M. The most elegant immunological experiment of the XIX century. Nat. Immunol. 1, 93-94 (2000).
    • (2000) Nat. Immunol. , vol.1 , pp. 93-94
    • Silverstein, A.M.1
  • 9
    • 84892487790 scopus 로고    scopus 로고
    • Trends in allergic conditions among children: United States, 1997-2011
    • Jackson, K. D., Howie, L. D. & Akinbami, L. J. Trends in allergic conditions among children: United States, 1997-2011. NCHS Data Brief 121, 1-8 (2013).
    • (2013) NCHS Data Brief , vol.121 , pp. 1-8
    • Jackson, K.D.1    Howie, L.D.2    Akinbami, L.J.3
  • 10
    • 84866752292 scopus 로고    scopus 로고
    • Trends in asthma prevalence, health care use, and mortality in the United States, 2001-2010
    • Akinbami, L. J. et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001-2010. NCHS Data Brief 94, 1-8 (2012).
    • (2012) NCHS Data Brief , vol.94 , pp. 1-8
    • Akinbami, L.J.1
  • 11
    • 84902657771 scopus 로고    scopus 로고
    • Diet, metabolites, and "Western-lifestyle" inflammatory diseases
    • Thorburn, A. N., Macia, L. & Mackay, C. R. Diet, metabolites, and "Western-lifestyle" inflammatory diseases. Immunity 40, 833-842 (2014).
    • (2014) Immunity , vol.40 , pp. 833-842
    • Thorburn, A.N.1    Macia, L.2    Mackay, C.R.3
  • 12
    • 84875647486 scopus 로고    scopus 로고
    • Neuronal connectivity as a convergent target of gene x environment interactions that confer risk for autism spectrum disorders
    • Stamou, M., Streifel, K. M., Goines, P. E. & Lein, P. J. Neuronal connectivity as a convergent target of gene x environment interactions that confer risk for autism spectrum disorders. Neurotoxicol. Teratol. 36, 3-16 (2013).
    • (2013) Neurotoxicol. Teratol. , vol.36 , pp. 3-16
    • Stamou, M.1    Streifel, K.M.2    Goines, P.E.3    Lein, P.J.4
  • 13
    • 84901636483 scopus 로고    scopus 로고
    • Vaccines are not associated with autism: An evidence-based meta-analysis of case-control and cohort studies
    • Taylor, L. E., Swerdfeger, A. L. & Eslick, G. D. Vaccines are not associated with autism: an evidence-based meta-analysis of case-control and cohort studies. Vaccine 32, 3623-3629 (2014).
    • (2014) Vaccine , vol.32 , pp. 3623-3629
    • Taylor, L.E.1    Swerdfeger, A.L.2    Eslick, G.D.3
  • 14
    • 0028906338 scopus 로고
    • Autism as a strongly genetic disorder: Evidence from a British twin study
    • Bailey, A. et al. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol. Med. 25, 63-77 (1995).
    • (1995) Psychol. Med. , vol.25 , pp. 63-77
    • Bailey, A.1
  • 15
    • 0024523493 scopus 로고
    • A twin study of autism in Denmark, Finland, Iceland, Norway and Sweden
    • Steffenburg, S. et al. A twin study of autism in Denmark, Finland, Iceland, Norway and Sweden. J. Child Psychol. Psychiatry 30, 405-416 (1989).
    • (1989) J. Child Psychol. Psychiatry , vol.30 , pp. 405-416
    • Steffenburg, S.1
  • 16
    • 84899784475 scopus 로고    scopus 로고
    • The familial risk of autism
    • Sandin, S. et al. The familial risk of autism. JAMA 311, 1770-1777 (2014).
    • (2014) JAMA , vol.311 , pp. 1770-1777
    • Sandin, S.1
  • 17
    • 84862493260 scopus 로고    scopus 로고
    • Genetic architecture in autism spectrum disorder
    • Devlin, B. & Scherer, S. W. Genetic architecture in autism spectrum disorder. Curr. Opin. Genet. Dev. 22, 229-237 (2012).
    • (2012) Curr. Opin. Genet. Dev. , vol.22 , pp. 229-237
    • Devlin, B.1    Scherer, S.W.2
  • 18
    • 84905582433 scopus 로고    scopus 로고
    • Most genetic risk for autism resides with common variation
    • Gaugler, T. et al. Most genetic risk for autism resides with common variation. Nat. Genet. 46, 881-885 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 881-885
    • Gaugler, T.1
  • 19
    • 84864335157 scopus 로고    scopus 로고
    • Autism genetics: Searching for specificity and convergence
    • Berg, J. M. & Geschwind, D. H. Autism genetics: searching for specificity and convergence. Genome Biol. 13, 247 (2012).
    • (2012) Genome Biol. , vol.13 , pp. 247
    • Berg, J.M.1    Geschwind, D.H.2
  • 20
    • 84908587395 scopus 로고    scopus 로고
    • Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders
    • Santini, E. & Klann, E. Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders. Sci. Signal. 7, re10 (2014).
    • (2014) Sci. Signal. , vol.7 , pp. re10
    • Santini, E.1    Klann, E.2
  • 21
    • 84861229141 scopus 로고    scopus 로고
    • Molecular therapies for tuberous sclerosis and neurofibromatosis
    • Franz, D. N. & Weiss, B. D. Molecular therapies for tuberous sclerosis and neurofibromatosis. Curr. Neurol. Neurosci. Rep. 12, 294-301 (2012).
    • (2012) Curr. Neurol. Neurosci. Rep. , vol.12 , pp. 294-301
    • Franz, D.N.1    Weiss, B.D.2
  • 22
    • 79958071067 scopus 로고    scopus 로고
    • Solving the autism puzzle a few pieces at a time
    • Schaaf, C. P. & Zoghbi, H. Y. Solving the autism puzzle a few pieces at a time. Neuron 70, 806-808 (2011).
    • (2011) Neuron , vol.70 , pp. 806-808
    • Schaaf, C.P.1    Zoghbi, H.Y.2
  • 23
    • 40749089626 scopus 로고    scopus 로고
    • Structural variation of chromosomes in autism spectrum disorder
    • Marshall, C. R. et al. Structural variation of chromosomes in autism spectrum disorder. Am. J. Hum. Genet. 82, 477-488 (2008).
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 477-488
    • Marshall, C.R.1
  • 24
    • 42649096881 scopus 로고    scopus 로고
    • Autism genetics: Strategies, challenges, and opportunities
    • O'Roak, B. J. & State, M. W. Autism genetics: strategies, challenges, and opportunities. Autism Res. 1, 4-17 (2008).
    • (2008) Autism Res. , vol.1 , pp. 4-17
    • O'Roak, B.J.1    State, M.W.2
  • 25
    • 84863988574 scopus 로고    scopus 로고
    • Genome-wide transcriptome profiling reveals the functional impact of rare de novo and recurrent CNVs in autism spectrum disorders
    • Luo, R. et al. Genome-wide transcriptome profiling reveals the functional impact of rare de novo and recurrent CNVs in autism spectrum disorders. Am. J. Hum. Genet. 91, 38-55 (2012).
    • (2012) Am. J. Hum. Genet. , vol.91 , pp. 38-55
    • Luo, R.1
  • 26
    • 84888398390 scopus 로고    scopus 로고
    • MET receptor tyrosine kinase as an autism genetic risk factor
    • Peng, Y., Huentelman, M., Smith, C. & Qiu, S. MET receptor tyrosine kinase as an autism genetic risk factor. Int. Rev. Neurobiol. 113, 135-165 (2013).
    • (2013) Int. Rev. Neurobiol. , vol.113 , pp. 135-165
    • Peng, Y.1    Huentelman, M.2    Smith, C.3    Qiu, S.4
  • 27
    • 34948876359 scopus 로고    scopus 로고
    • Disruption of cerebral cortex MET signaling in autism spectrum disorder
    • Campbell, D. B. et al. Disruption of cerebral cortex MET signaling in autism spectrum disorder. Ann. Neurol. 62, 243-250 (2007).
    • (2007) Ann. Neurol. , vol.62 , pp. 243-250
    • Campbell, D.B.1
  • 28
    • 67349154764 scopus 로고    scopus 로고
    • Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder
    • Campbell, D. B., Li, C., Sutcliffe, J. S., Persico, A. M. & Levitt, P. Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder. Autism Res. 1, 159-168 (2008).
    • (2008) Autism Res. , vol.1 , pp. 159-168
    • Campbell, D.B.1    Li, C.2    Sutcliffe, J.S.3    Persico, A.M.4    Levitt, P.5
  • 29
    • 70349323427 scopus 로고    scopus 로고
    • Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder
    • Jackson, P. B. et al. Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder. Autism Res. 2, 232-236 (2009).
    • (2009) Autism Res. , vol.2 , pp. 232-236
    • Jackson, P.B.1
  • 30
    • 79959262465 scopus 로고    scopus 로고
    • Transcriptomic analysis of autistic brain reveals convergent molecular pathology
    • Voineagu, I. et al. Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature 474, 380-384 (2011).
    • (2011) Nature , vol.474 , pp. 380-384
    • Voineagu, I.1
  • 31
    • 84865979545 scopus 로고    scopus 로고
    • Autism-associated promoter variant in MET impacts functional and structural brain networks
    • Rudie, J. D. et al. Autism-associated promoter variant in MET impacts functional and structural brain networks. Neuron 75, 904-915 (2012).
    • (2012) Neuron , vol.75 , pp. 904-915
    • Rudie, J.D.1
  • 32
    • 84871442139 scopus 로고    scopus 로고
    • Autism risk gene MET variation and cortical thickness in typically developing children and adolescents
    • Hedrick, A. et al. Autism risk gene MET variation and cortical thickness in typically developing children and adolescents. Autism Res. 5, 434-439 (2012).
    • (2012) Autism Res. , vol.5 , pp. 434-439
    • Hedrick, A.1
  • 33
    • 84886855303 scopus 로고    scopus 로고
    • Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome
    • Plummer, J. T. et al. Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome. Transl Psychiatry 3, e316 (2013).
    • (2013) Transl Psychiatry , vol.3 , pp. e316
    • Plummer, J.T.1
  • 34
    • 33745616804 scopus 로고    scopus 로고
    • low/neg accessory cells with dendritic-cell features
    • low/neg accessory cells with dendritic-cell features. Blood 108, 218-227 (2006).
    • (2006) Blood , vol.108 , pp. 218-227
    • Rutella, S.1
  • 35
    • 25444439797 scopus 로고    scopus 로고
    • A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function
    • Okunishi, K. et al. A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function. J. Immunol. 175, 4745-4753 (2005).
    • (2005) J. Immunol. , vol.175 , pp. 4745-4753
    • Okunishi, K.1
  • 36
    • 0141519493 scopus 로고    scopus 로고
    • Hepatocyte growth factor facilitates colonic mucosal repair in experimental ulcerative colitis in rats
    • Tahara, Y. et al. Hepatocyte growth factor facilitates colonic mucosal repair in experimental ulcerative colitis in rats. J. Pharmacol. Exp. Ther. 307, 146-151 (2003).
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , pp. 146-151
    • Tahara, Y.1
  • 37
    • 27944464966 scopus 로고    scopus 로고
    • Mucosal repair and growth factors: Recombinant human hepatocyte growth factor as an innovative therapy for inflammatory bowel disease
    • Ido, A., Numata, M., Kodama, M. & Tsubouchi, H. Mucosal repair and growth factors: recombinant human hepatocyte growth factor as an innovative therapy for inflammatory bowel disease. J. Gastroenterol. 40, 925-931 (2005).
    • (2005) J. Gastroenterol. , vol.40 , pp. 925-931
    • Ido, A.1    Numata, M.2    Kodama, M.3    Tsubouchi, H.4
  • 38
    • 38449089158 scopus 로고    scopus 로고
    • Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice
    • Okunishi, K. et al. Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice. J. Immunol. 179, 5504-5513 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 5504-5513
    • Okunishi, K.1
  • 39
    • 20944452151 scopus 로고    scopus 로고
    • Hepatocyte growth factor ameliorates the progression of experimental autoimmune myocarditis: A potential role for induction of T helper 2 cytokines
    • Futamatsu, H. et al. Hepatocyte growth factor ameliorates the progression of experimental autoimmune myocarditis: a potential role for induction of T helper 2 cytokines. Circ. Res. 96, 823-830 (2005).
    • (2005) Circ. Res. , vol.96 , pp. 823-830
    • Futamatsu, H.1
  • 40
    • 35648975634 scopus 로고    scopus 로고
    • Hepatocyte growth factor prevents lupus nephritis in a murine lupus model of chronic graft-versus-host disease
    • Kuroiwa, T. et al. Hepatocyte growth factor prevents lupus nephritis in a murine lupus model of chronic graft-versus-host disease. Arthritis Res. Ther. 8, R123 (2006).
    • (2006) Arthritis Res. Ther. , vol.8 , pp. R123
    • Kuroiwa, T.1
  • 41
    • 15244359669 scopus 로고    scopus 로고
    • Ameliorating effect of hepatocyte growth factor on inflammatory bowel disease in a murine model
    • Oh, K. et al. Ameliorating effect of hepatocyte growth factor on inflammatory bowel disease in a murine model. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G729-G735 (2005).
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.288 , pp. G729-G735
    • Oh, K.1
  • 42
    • 16344367737 scopus 로고    scopus 로고
    • HGF reduces advancing lung fibrosis in mice: A potential role for MMP-dependent myofibroblast apoptosis
    • Mizuno, S., Matsumoto, K., Li, M. Y. & Nakamura, T. HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis. FASEB J. 19, 580-582 (2005).
    • (2005) FASEB J. , vol.19 , pp. 580-582
    • Mizuno, S.1    Matsumoto, K.2    Li, M.Y.3    Nakamura, T.4
  • 43
    • 80054823145 scopus 로고    scopus 로고
    • Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression
    • Heuer, L., Braunschweig, D., Ashwood, P., Van de Water, J. & Campbell, D. B. Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression. Translat. Psychiatry 1, e48 (2011).
    • (2011) Translat. Psychiatry , vol.1 , pp. e48
    • Heuer, L.1    Braunschweig, D.2    Ashwood, P.3    Van De Water, J.4    Campbell, D.B.5
  • 44
    • 77953935509 scopus 로고    scopus 로고
    • Interleukin-10: A multi-faceted agent of pregnancy
    • Thaxton, J. E. & Sharma, S. Interleukin-10: a multi-faceted agent of pregnancy. Am. J. Reprod. Immunol. 63, 482-491 (2010).
    • (2010) Am. J. Reprod. Immunol. , vol.63 , pp. 482-491
    • Thaxton, J.E.1    Sharma, S.2
  • 45
    • 84890117281 scopus 로고    scopus 로고
    • Autism spectrum disorder: Interaction of air pollution with the MET receptor tyrosine kinase gene
    • Volk, H. E. et al. Autism spectrum disorder: interaction of air pollution with the MET receptor tyrosine kinase gene. Epidemiology 25, 44-47 (2014).
    • (2014) Epidemiology , vol.25 , pp. 44-47
    • Volk, H.E.1
  • 46
    • 84888397448 scopus 로고    scopus 로고
    • Immune dysregulation in autism spectrum disorder
    • Hsiao, E. Y. Immune dysregulation in autism spectrum disorder. Int. Rev. Neurobiol. 113, 269-302 (2013).
    • (2013) Int. Rev. Neurobiol. , vol.113 , pp. 269-302
    • Hsiao, E.Y.1
  • 47
    • 84865850000 scopus 로고    scopus 로고
    • The major histocompatibility complex and autism spectrum disorder
    • Needleman, L. A. & McAllister, A. K. The major histocompatibility complex and autism spectrum disorder. Dev. Neurobiol. 72, 1288-1301 (2012).
    • (2012) Dev. Neurobiol. , vol.72 , pp. 1288-1301
    • Needleman, L.A.1    McAllister, A.K.2
  • 48
    • 41749088902 scopus 로고    scopus 로고
    • The HLA region and autoimmune disease: Associations and mechanisms of action
    • Gough, S. C. & Simmonds, M. J. The HLA region and autoimmune disease: associations and mechanisms of action. Curr. Genom. 8, 453-465 (2007).
    • (2007) Curr. Genom. , vol.8 , pp. 453-465
    • Gough, S.C.1    Simmonds, M.J.2
  • 49
    • 77958496538 scopus 로고    scopus 로고
    • Parental autoimmune diseases associated with autism spectrum disorders in offspring
    • Keil, A. et al. Parental autoimmune diseases associated with autism spectrum disorders in offspring. Epidemiology 21, 805-808 (2010).
    • (2010) Epidemiology , vol.21 , pp. 805-808
    • Keil, A.1
  • 50
    • 84872666594 scopus 로고    scopus 로고
    • The link between some alleles on human leukocyte antigen system and autism in children
    • Mostafa, G. A., Shehab, A. A. & Al-Ayadhi, L. Y. The link between some alleles on human leukocyte antigen system and autism in children. J. Neuroimmunol. 255, 70-74 (2013).
    • (2013) J. Neuroimmunol. , vol.255 , pp. 70-74
    • Mostafa, G.A.1    Shehab, A.A.2    Al-Ayadhi, L.Y.3
  • 52
    • 0026071479 scopus 로고
    • Increased frequency of the null allele at the complement C4b locus in autism
    • Warren, R. P. et al. Increased frequency of the null allele at the complement C4b locus in autism. Clin. Exp. Immunol. 83, 438-440 (1991).
    • (1991) Clin. Exp. Immunol. , vol.83 , pp. 438-440
    • Warren, R.P.1
  • 53
    • 78649830454 scopus 로고    scopus 로고
    • Genetic susceptibility to systemic lupus erythematosus in the genomic era
    • Deng, Y. & Tsao, B. P. Genetic susceptibility to systemic lupus erythematosus in the genomic era. Nat. Rev. Rheumatol. 6, 683-692 (2010).
    • (2010) Nat. Rev. Rheumatol. , vol.6 , pp. 683-692
    • Deng, Y.1    Tsao, B.P.2
  • 54
    • 77953542948 scopus 로고    scopus 로고
    • The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children
    • Mostafa, G. A. & Shehab, A. A. The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children. J. Neuroimmunol. 223, 115-119 (2010).
    • (2010) J. Neuroimmunol. , vol.223 , pp. 115-119
    • Mostafa, G.A.1    Shehab, A.A.2
  • 55
    • 84868706041 scopus 로고    scopus 로고
    • Autism spectrum disorders: From immunity to behavior
    • Careaga, M. & Ashwood, P. Autism spectrum disorders: from immunity to behavior. Methods Mol. Biol. 934, 219-240 (2012).
    • (2012) Methods Mol. Biol. , vol.934 , pp. 219-240
    • Careaga, M.1    Ashwood, P.2
  • 56
    • 79957589237 scopus 로고    scopus 로고
    • Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations
    • O'Roak, B. J. et al. Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations. Nat. Genet. 43, 585-589 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 585-589
    • O'Roak, B.J.1
  • 57
    • 84860780495 scopus 로고    scopus 로고
    • De novo mutations revealed by whole-exome sequencing are strongly associated with autism
    • Sanders, S. J. et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature 485, 237-241 (2012).
    • (2012) Nature , vol.485 , pp. 237-241
    • Sanders, S.J.1
  • 58
    • 80052964856 scopus 로고    scopus 로고
    • Understanding the contribution of synonymous mutations to human disease
    • Sauna, Z. E. & Kimchi-Sarfaty, C. Understanding the contribution of synonymous mutations to human disease. Nat. Rev. Genet. 12, 683-691 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 683-691
    • Sauna, Z.E.1    Kimchi-Sarfaty, C.2
  • 59
    • 34250212837 scopus 로고    scopus 로고
    • How do synonymous mutations affect fitness?
    • Parmley, J. L. & Hurst, L. D. How do synonymous mutations affect fitness? Bioessays 29, 515-519 (2007).
    • (2007) Bioessays , vol.29 , pp. 515-519
    • Parmley, J.L.1    Hurst, L.D.2
  • 60
    • 84883821082 scopus 로고    scopus 로고
    • Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: Presynaptic hubs for synapse organization
    • Takahashi, H. & Craig, A. M. Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization. Trends Neurosci. 36, 522-534 (2013).
    • (2013) Trends Neurosci. , vol.36 , pp. 522-534
    • Takahashi, H.1    Craig, A.M.2
  • 61
    • 37249045889 scopus 로고    scopus 로고
    • Disruption of the IL1RAPL1 gene associated with a pericentromeric inversion of the X chromosome in a patient with mental retardation and autism
    • Bhat, S. S. et al. Disruption of the IL1RAPL1 gene associated with a pericentromeric inversion of the X chromosome in a patient with mental retardation and autism. Clin. Genet. 73, 94-96 (2008).
    • (2008) Clin. Genet. , vol.73 , pp. 94-96
    • Bhat, S.S.1
  • 62
    • 0038377518 scopus 로고    scopus 로고
    • IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with neuronal calcium sensor-1 and regulates exocytosis
    • Bahi, N. et al. IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with neuronal calcium sensor-1 and regulates exocytosis. Hum. Mol. Genet. 12, 1415-1425 (2003).
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 1415-1425
    • Bahi, N.1
  • 63
    • 57049170205 scopus 로고    scopus 로고
    • Mutations in the calcium-related gene IL1RAPL1 are associated with autism
    • Piton, A. et al. Mutations in the calcium-related gene IL1RAPL1 are associated with autism. Hum. Mol. Genet. 17, 3965-3974 (2008).
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 3965-3974
    • Piton, A.1
  • 64
    • 84937635203 scopus 로고    scopus 로고
    • Toward an immune-mediated subtype of autism spectrum disorder
    • McDougle, C. J. et al. Toward an immune-mediated subtype of autism spectrum disorder. Brain Res. 1617, 72-92 (2014).
    • (2014) Brain Res. , vol.1617 , pp. 72-92
    • McDougle, C.J.1
  • 65
    • 67749109981 scopus 로고    scopus 로고
    • Association of family history of autoimmune diseases and autism spectrum disorders
    • Atladottir, H. O. et al. Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics 124, 687-694 (2009).
    • (2009) Pediatrics , vol.124 , pp. 687-694
    • Atladottir, H.O.1
  • 66
    • 84870447275 scopus 로고    scopus 로고
    • The co-morbidity burden of children and young adults with autism spectrum disorders
    • Kohane, I. S. et al. The co-morbidity burden of children and young adults with autism spectrum disorders. PLoS ONE 7, e33224 (2012).
    • (2012) PLoS ONE , vol.7
    • Kohane, I.S.1
  • 67
    • 67749114055 scopus 로고    scopus 로고
    • Immune involvement in schizophrenia and autism: Etiology, pathology and animal models
    • Patterson, P. H. Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav. Brain Res. 204, 313-321 (2009).
    • (2009) Behav. Brain Res. , vol.204 , pp. 313-321
    • Patterson, P.H.1
  • 68
    • 84871432078 scopus 로고    scopus 로고
    • 2H response is decreased during pregnancy in systemic lupus erythematosus
    • 2H response is decreased during pregnancy in systemic lupus erythematosus. Reumatismo 64, 314-320 (2012).
    • (2012) Reumatismo , vol.64 , pp. 314-320
    • Iaccarino, L.1
  • 70
    • 84888286336 scopus 로고    scopus 로고
    • Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder
    • Brimberg, L., Sadiq, A., Gregersen, P. K. & Diamond, B. Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder. Mol. Psychiatry 18, 1171-1177 (2013).
    • (2013) Mol. Psychiatry , vol.18 , pp. 1171-1177
    • Brimberg, L.1    Sadiq, A.2    Gregersen, P.K.3    Diamond, B.4
  • 71
    • 58149344949 scopus 로고    scopus 로고
    • Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus
    • Lee, J. Y. et al. Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus. Nat. Med. 15, 91-96 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 91-96
    • Lee, J.Y.1
  • 72
    • 55749095746 scopus 로고    scopus 로고
    • Pathogenic autoantibodies in systemic lupus erythematosus are derived from both self-reactive and non-self-reactive B cells
    • Zhang, J., Jacobi, A. M., Wang, T. & Diamond, B. Pathogenic autoantibodies in systemic lupus erythematosus are derived from both self-reactive and non-self-reactive B cells. Mol. Med. 14, 675-681 (2008).
    • (2008) Mol. Med. , vol.14 , pp. 675-681
    • Zhang, J.1    Jacobi, A.M.2    Wang, T.3    Diamond, B.4
  • 73
    • 84881370104 scopus 로고    scopus 로고
    • Anti-DNA antibodies cross-react with C1q
    • Franchin, G. et al. Anti-DNA antibodies cross-react with C1q. J. Autoimmun. 44, 34-39 (2013).
    • (2013) J. Autoimmun. , vol.44 , pp. 34-39
    • Franchin, G.1
  • 74
    • 84863458065 scopus 로고    scopus 로고
    • Female mouse fetal loss mediated by maternal autoantibody
    • Wang, L. et al. Female mouse fetal loss mediated by maternal autoantibody. J. Exp. Med. 209, 1083-1089 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 1083-1089
    • Wang, L.1
  • 75
    • 84894596234 scopus 로고    scopus 로고
    • Behavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection
    • Frazier, T. W., Georgiades, S., Bishop, S. L. & Hardan, A. Y. Behavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection. J. Am. Acad. Child Adolesc. Psychiatry 53, 329-340 (2014).
    • (2014) J. Am. Acad. Child Adolesc. Psychiatry , vol.53 , pp. 329-340
    • Frazier, T.W.1    Georgiades, S.2    Bishop, S.L.3    Hardan, A.Y.4
  • 76
  • 77
    • 84880178650 scopus 로고    scopus 로고
    • Autism-specific maternal autoantibodies recognize critical proteins in developing brain
    • Braunschweig, D. et al. Autism-specific maternal autoantibodies recognize critical proteins in developing brain. Transl Psychiatry 3, e277 (2013).
    • (2013) Transl Psychiatry , vol.3 , pp. e277
    • Braunschweig, D.1
  • 78
    • 46049095459 scopus 로고    scopus 로고
    • Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism
    • Martin, L. A. et al. Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain Behav. Immun. 22, 806-816 (2008).
    • (2008) Brain Behav. Immun. , vol.22 , pp. 806-816
    • Martin, L.A.1
  • 79
    • 84880166349 scopus 로고    scopus 로고
    • Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey
    • Bauman, M. D. et al. Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey. Transl Psychiatry 3, e278 (2013).
    • (2013) Transl Psychiatry , vol.3 , pp. e278
    • Bauman, M.D.1
  • 80
    • 34447573966 scopus 로고    scopus 로고
    • Accelerated maturation of white matter in young children with autism: A high b value DWI study
    • Ben Bashat, D. et al. Accelerated maturation of white matter in young children with autism: a high b value DWI study. Neuroimage 37, 40-47 (2007).
    • (2007) Neuroimage , vol.37 , pp. 40-47
    • Ben Bashat, D.1
  • 81
    • 84870065050 scopus 로고    scopus 로고
    • White matter connectivity in children with autism spectrum disorders: A tract-based spatial statistics study
    • Billeci, L., Calderoni, S., Tosetti, M., Catani, M. & Muratori, F. White matter connectivity in children with autism spectrum disorders: a tract-based spatial statistics study. BMC Neurol. 12, 148 (2012).
    • (2012) BMC Neurol. , vol.12 , pp. 148
    • Billeci, L.1    Calderoni, S.2    Tosetti, M.3    Catani, M.4    Muratori, F.5
  • 82
    • 84861660149 scopus 로고    scopus 로고
    • Differences in white matter fiber tract development present from 6 to 24 months in infants with autism
    • Wolff, J. J. et al. Differences in white matter fiber tract development present from 6 to 24 months in infants with autism. Am. J. Psychiatry 169, 589-600 (2012).
    • (2012) Am. J. Psychiatry , vol.169 , pp. 589-600
    • Wolff, J.J.1
  • 83
    • 67349116508 scopus 로고    scopus 로고
    • Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: A pregnant dam mouse model
    • Singer, H. S. et al. Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: a pregnant dam mouse model. J. Neuroimmunol. 211, 39-48 (2009).
    • (2009) J. Neuroimmunol. , vol.211 , pp. 39-48
    • Singer, H.S.1
  • 84
    • 84896515133 scopus 로고    scopus 로고
    • Embryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autistic-like stereotypical behaviors in offspring mice
    • Camacho, J. et al. Embryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autistic-like stereotypical behaviors in offspring mice. Behav. Brain Res. 266, 46-51 (2014).
    • (2014) Behav. Brain Res. , vol.266 , pp. 46-51
    • Camacho, J.1
  • 85
    • 79959964671 scopus 로고    scopus 로고
    • Maternal infection and immune involvement in autism
    • Patterson, P. H. Maternal infection and immune involvement in autism. Trends Mol. Med. 17, 389-394 (2011).
    • (2011) Trends Mol. Med. , vol.17 , pp. 389-394
    • Patterson, P.H.1
  • 86
    • 0014970976 scopus 로고
    • Autism in children with congenital rubella
    • Chess, S. Autism in children with congenital rubella. J. Autism Child. Schizophr. 1, 33-47 (1971).
    • (1971) J. Autism Child. Schizophr. , vol.1 , pp. 33-47
    • Chess, S.1
  • 87
    • 0017360565 scopus 로고
    • Follow-up report on autism in congenital rubella
    • Chess, S. Follow-up report on autism in congenital rubella. J. Autism Child. Schizophr. 7, 69-81 (1977).
    • (1977) J. Autism Child. Schizophr. , vol.7 , pp. 69-81
    • Chess, S.1
  • 88
    • 0016795487 scopus 로고
    • Letter: Congenital rubella and autistic behavior
    • Swisher, C. N. & Swisher, L. Letter: congenital rubella and autistic behavior. N. Engl. J. Med. 293, 198 (1975).
    • (1975) N. Engl. J. Med. , vol.293 , pp. 198
    • Swisher, C.N.1    Swisher, L.2
  • 89
    • 84884254985 scopus 로고    scopus 로고
    • Amniotic fluid inflammatory cytokines: Potential markers of immunologic dysfunction in autism spectrum disorders
    • Abdallah, M. W. et al. Amniotic fluid inflammatory cytokines: potential markers of immunologic dysfunction in autism spectrum disorders. World J. Biol. Psychiatry 14, 528-538 (2013).
    • (2013) World J. Biol. Psychiatry , vol.14 , pp. 528-538
    • Abdallah, M.W.1
  • 90
    • 84857191889 scopus 로고    scopus 로고
    • Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: A case-control study
    • Goines, P. E. et al. Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: a case-control study. Mol. Autism 2, 13 (2011).
    • (2011) Mol. Autism , vol.2 , pp. 13
    • Goines, P.E.1
  • 91
    • 78549271649 scopus 로고    scopus 로고
    • Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders
    • Atladottir, H. O. et al. Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. J. Autism Dev. Disord. 40, 1423-1430 (2010).
    • (2010) J. Autism Dev. Disord. , vol.40 , pp. 1423-1430
    • Atladottir, H.O.1
  • 92
    • 84870499875 scopus 로고    scopus 로고
    • Autism after infection, febrile episodes, and antibiotic use during pregnancy: An exploratory study
    • Atladottir, H. O., Henriksen, T. B., Schendel, D. E. & Parner, E. T. Autism after infection, febrile episodes, and antibiotic use during pregnancy: an exploratory study. Pediatrics 130, e1447-e1454 (2012).
    • (2012) Pediatrics , vol.130 , pp. e1447-e1454
    • Atladottir, H.O.1    Henriksen, T.B.2    Schendel, D.E.3    Parner, E.T.4
  • 93
    • 84908641541 scopus 로고    scopus 로고
    • The risk for behavioural deficits is determined by the maternal immune response to prenatal immune challenge in a neurodevelopmental model
    • Missault, S. et al. The risk for behavioural deficits is determined by the maternal immune response to prenatal immune challenge in a neurodevelopmental model. Brain Behav. Immun. 42, 138-46 (2014).
    • (2014) Brain Behav. Immun. , vol.42 , pp. 138-146
    • Missault, S.1
  • 94
    • 0036471969 scopus 로고    scopus 로고
    • Maternal infection: Window on neuroimmune interactions in fetal brain development and mental illness
    • Patterson, P. H. Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness. Curr. Opin. Neurobiol. 12, 115-118 (2002).
    • (2002) Curr. Opin. Neurobiol. , vol.12 , pp. 115-118
    • Patterson, P.H.1
  • 95
    • 84908483881 scopus 로고    scopus 로고
    • Maternal immune activation and abnormal brain development across CNS disorders
    • Knuesel, I. et al. Maternal immune activation and abnormal brain development across CNS disorders. Nat. Rev. Neurol. 10, 643-660 (2014).
    • (2014) Nat. Rev. Neurol. , vol.10 , pp. 643-660
    • Knuesel, I.1
  • 96
    • 35148872226 scopus 로고    scopus 로고
    • Maternal immune activation alters fetal brain development through interleukin-6
    • Smith, S. E., Li, J., Garbett, K., Mirnics, K. & Patterson, P. H. Maternal immune activation alters fetal brain development through interleukin-6. J. Neurosci. 27, 10695-10702 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 10695-10702
    • Smith, S.E.1    Li, J.2    Garbett, K.3    Mirnics, K.4    Patterson, P.H.5
  • 97
    • 84858740384 scopus 로고    scopus 로고
    • Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism
    • Malkova, N. V., Yu, C. Z., Hsiao, E. Y., Moore, M. J. & Patterson, P. H. Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Brain Behav. Immun. 26, 607-616 (2012).
    • (2012) Brain Behav. Immun. , vol.26 , pp. 607-616
    • Malkova, N.V.1    Yu, C.Z.2    Hsiao, E.Y.3    Moore, M.J.4    Patterson, P.H.5
  • 98
    • 84892588761 scopus 로고    scopus 로고
    • Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring
    • Bauman, M. D. et al. Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring. Biol. Psychiatry 75, 332-341 (2014).
    • (2014) Biol. Psychiatry , vol.75 , pp. 332-341
    • Bauman, M.D.1
  • 99
    • 56949092229 scopus 로고    scopus 로고
    • Activation of the maternal immune system alters cerebellar development in the offspring
    • Shi, L. et al. Activation of the maternal immune system alters cerebellar development in the offspring. Brain Behav. Immun. 23, 116-123 (2009).
    • (2009) Brain Behav. Immun. , vol.23 , pp. 116-123
    • Shi, L.1
  • 101
    • 34648832289 scopus 로고    scopus 로고
    • Cytokine levels during pregnancy influence immunological profiles and neurobehavioral patterns of the offspring
    • Ponzio, N. M., Servatius, R., Beck, K., Marzouk, A. & Kreider, T. Cytokine levels during pregnancy influence immunological profiles and neurobehavioral patterns of the offspring. Ann. NY Acad. Sci. 1107, 118-128 (2007).
    • (2007) Ann. NY Acad. Sci. , vol.1107 , pp. 118-128
    • Ponzio, N.M.1    Servatius, R.2    Beck, K.3    Marzouk, A.4    Kreider, T.5
  • 102
    • 38349115639 scopus 로고    scopus 로고
    • Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling
    • Meyer, U. et al. Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling. Mol. Psychiatry 13, 208-221 (2008).
    • (2008) Mol. Psychiatry , vol.13 , pp. 208-221
    • Meyer, U.1
  • 103
    • 84857190395 scopus 로고    scopus 로고
    • The role of immune dysfunction in the pathophysiology of autism
    • Onore, C., Careaga, M. & Ashwood, P. The role of immune dysfunction in the pathophysiology of autism. Brain Behav. Immun. 26, 383-392 (2012).
    • (2012) Brain Behav. Immun. , vol.26 , pp. 383-392
    • Onore, C.1    Careaga, M.2    Ashwood, P.3
  • 104
    • 84880764625 scopus 로고    scopus 로고
    • The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children
    • Mostafa, G. A. & Al-Ayadhi, L. Y. The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children. J. Neuroimmunol. 261, 77-81 (2013).
    • (2013) J. Neuroimmunol. , vol.261 , pp. 77-81
    • Mostafa, G.A.1    Al-Ayadhi, L.Y.2
  • 105
    • 0030886961 scopus 로고    scopus 로고
    • Circulating autoantibodies to neuronal and glial filament proteins in autism
    • Singh, V. K., Warren, R., Averett, R. & Ghaziuddin, M. Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatr. Neurol. 17, 88-90 (1997).
    • (1997) Pediatr. Neurol. , vol.17 , pp. 88-90
    • Singh, V.K.1    Warren, R.2    Averett, R.3    Ghaziuddin, M.4
  • 106
  • 107
    • 0036344430 scopus 로고    scopus 로고
    • Antibodies to neuron-specific antigens in children with autism: Possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A
    • Vojdani, A. et al. Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A. J. Neuroimmunol. 129, 168-177 (2002).
    • (2002) J. Neuroimmunol. , vol.129 , pp. 168-177
    • Vojdani, A.1
  • 108
    • 33748189764 scopus 로고    scopus 로고
    • Antibrain antibodies in children with autism and their unaffected siblings
    • Singer, H. S. et al. Antibrain antibodies in children with autism and their unaffected siblings. J. Neuroimmunol. 178, 149-155 (2006).
    • (2006) J. Neuroimmunol. , vol.178 , pp. 149-155
    • Singer, H.S.1
  • 109
    • 0030990508 scopus 로고    scopus 로고
    • Hyperserotoninemia and serotonin receptor antibodies in children with autism but not mental retardation
    • Singh, V. K., Singh, E. A. & Warren, R. P. Hyperserotoninemia and serotonin receptor antibodies in children with autism but not mental retardation. Biol. Psychiatry 41, 753-755 (1997).
    • (1997) Biol. Psychiatry , vol.41 , pp. 753-755
    • Singh, V.K.1    Singh, E.A.2    Warren, R.P.3
  • 110
    • 0347914616 scopus 로고    scopus 로고
    • Prevalence of serum antibodies to caudate nucleus in autistic children
    • Singh, V. K. & Rivas, W. H. Prevalence of serum antibodies to caudate nucleus in autistic children. Neurosci. Lett. 355, 53-56 (2004).
    • (2004) Neurosci. Lett. , vol.355 , pp. 53-56
    • Singh, V.K.1    Rivas, W.H.2
  • 111
    • 3042615494 scopus 로고    scopus 로고
    • Autoantibody repertoires to brain tissue in autism nuclear families
    • Silva, S. C. et al. Autoantibody repertoires to brain tissue in autism nuclear families. J. Neuroimmunol. 152, 176-182 (2004).
    • (2004) J. Neuroimmunol. , vol.152 , pp. 176-182
    • Silva, S.C.1
  • 112
    • 34648837683 scopus 로고    scopus 로고
    • Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder
    • Cabanlit, M., Wills, S., Goines, P., Ashwood, P. & Van de Water, J. Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Ann. NY Acad. Sci. 1107, 92-103 (2007).
    • (2007) Ann. NY Acad. Sci. , vol.1107 , pp. 92-103
    • Cabanlit, M.1    Wills, S.2    Goines, P.3    Ashwood, P.4    Van De Water, J.5
  • 113
    • 56949085021 scopus 로고    scopus 로고
    • Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders
    • Wills, S. et al. Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders. Brain Behav. Immun. 23, 64-74 (2009).
    • (2009) Brain Behav. Immun. , vol.23 , pp. 64-74
    • Wills, S.1
  • 114
    • 69849086849 scopus 로고    scopus 로고
    • Childhood serum anti-fetal brain antibodies do not predict autism
    • Morris, C. M., Zimmerman, A. W. & Singer, H. S. Childhood serum anti-fetal brain antibodies do not predict autism. Pediatr. Neurol. 41, 288-290 (2009).
    • (2009) Pediatr. Neurol. , vol.41 , pp. 288-290
    • Morris, C.M.1    Zimmerman, A.W.2    Singer, H.S.3
  • 115
    • 79551687313 scopus 로고    scopus 로고
    • Autoantibodies to cerebellum in children with autism associate with behavior
    • Goines, P. et al. Autoantibodies to cerebellum in children with autism associate with behavior. Brain Behav. Immun. 25, 514-523 (2011).
    • (2011) Brain Behav. Immun. , vol.25 , pp. 514-523
    • Goines, P.1
  • 116
    • 11144230769 scopus 로고    scopus 로고
    • Neuroglial activation and neuroinflammation in the brain of patients with autism
    • Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W. & Pardo, C. A. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann. Neurol. 57, 67-81 (2005).
    • (2005) Ann. Neurol. , vol.57 , pp. 67-81
    • Vargas, D.L.1    Nascimbene, C.2    Krishnan, C.3    Zimmerman, A.W.4    Pardo, C.A.5
  • 117
    • 33244493984 scopus 로고    scopus 로고
    • Elevated cytokine levels in children with autism spectrum disorder
    • Molloy, C. A. et al. Elevated cytokine levels in children with autism spectrum disorder. J. Neuroimmunol. 172, 198-205 (2006).
    • (2006) J. Neuroimmunol. , vol.172 , pp. 198-205
    • Molloy, C.A.1
  • 118
    • 33845679801 scopus 로고    scopus 로고
    • Decreased serum levels of transforming growth factor-β1 in patients with autism
    • Okada, K. et al. Decreased serum levels of transforming growth factor-β1 in patients with autism. Prog. Neuropsychopharmacol. Biol. Psychiatry 31, 187-190 (2007).
    • (2007) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.31 , pp. 187-190
    • Okada, K.1
  • 119
    • 54349091759 scopus 로고    scopus 로고
    • Decreased transforming growth factor β1 in autism: A potential link between immune dysregulation and impairment in clinical behavioral outcomes
    • Ashwood, P. et al. Decreased transforming growth factor β1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes. J. Neuroimmunol. 204, 149-153 (2008).
    • (2008) J. Neuroimmunol. , vol.204 , pp. 149-153
    • Ashwood, P.1
  • 120
    • 78649322790 scopus 로고    scopus 로고
    • Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome
    • Ashwood, P. et al. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav. Immun. 25, 40-45 (2011).
    • (2011) Brain Behav. Immun. , vol.25 , pp. 40-45
    • Ashwood, P.1
  • 121
    • 79952244924 scopus 로고    scopus 로고
    • Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders
    • Ashwood, P. et al. Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. J. Neuroimmunol. 232, 196-199 (2011).
    • (2011) J. Neuroimmunol. , vol.232 , pp. 196-199
    • Ashwood, P.1
  • 122
    • 84867140037 scopus 로고    scopus 로고
    • Neonatal levels of cytokines and risk of autism spectrum disorders: An exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank
    • Abdallah, M. W. et al. Neonatal levels of cytokines and risk of autism spectrum disorders: an exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank. J. Neuroimmunol. 252, 75-82 (2012).
    • (2012) J. Neuroimmunol. , vol.252 , pp. 75-82
    • Abdallah, M.W.1
  • 123
    • 84874937105 scopus 로고    scopus 로고
    • Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder
    • Napolioni, V. et al. Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder. J. Neuroinflammation 10, 38 (2013).
    • (2013) J. Neuroinflammation , vol.10 , pp. 38
    • Napolioni, V.1
  • 125
    • 71749094505 scopus 로고    scopus 로고
    • Differential monocyte responses to TLR ligands in children with autism spectrum disorders
    • Enstrom, A. M., Onore, C. E., Van de Water, J. A. & Ashwood, P. Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain Behav. Immun. 24, 64-71 (2010).
    • (2010) Brain Behav. Immun. , vol.24 , pp. 64-71
    • Enstrom, A.M.1    Onore, C.E.2    Van De Water, J.A.3    Ashwood, P.4
  • 127
    • 79957896374 scopus 로고    scopus 로고
    • Altered T cell responses in children with autism
    • Ashwood, P. et al. Altered T cell responses in children with autism. Brain Behav. Immun. 25, 840-849 (2011).
    • (2011) Brain Behav. Immun. , vol.25 , pp. 840-849
    • Ashwood, P.1
  • 129
    • 0028906527 scopus 로고
    • DR-positive T cells in autism: Association with decreased plasma levels of the complement C4B protein
    • Warren, R. P., Yonk, J., Burger, R. W., Odell, D. & Warren, W. L. DR-positive T cells in autism: association with decreased plasma levels of the complement C4B protein. Neuropsychobiology 31, 53-57 (1995).
    • (1995) Neuropsychobiology , vol.31 , pp. 53-57
    • Warren, R.P.1    Yonk, J.2    Burger, R.W.3    Odell, D.4    Warren, W.L.5
  • 130
    • 0017602126 scopus 로고
    • Depressed lymphocyte responsiveness in autistic children
    • Stubbs, E. G. & Crawford, M. L. Depressed lymphocyte responsiveness in autistic children. J. Autism Child. Schizophr. 7, 49-55 (1977).
    • (1977) J. Autism Child. Schizophr. , vol.7 , pp. 49-55
    • Stubbs, E.G.1    Crawford, M.L.2
  • 132
    • 77952311924 scopus 로고    scopus 로고
    • Regulation of learning and memory by meningeal immunity: A key role for IL-4
    • Derecki, N. C. et al. Regulation of learning and memory by meningeal immunity: a key role for IL-4. J. Exp. Med. 207, 1067-1080 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1067-1080
    • Derecki, N.C.1
  • 134
    • 84883821860 scopus 로고    scopus 로고
    • Maternal immune stimulation during pregnancy shapes the immunological phenotype of offspring
    • Mandal, M. et al. Maternal immune stimulation during pregnancy shapes the immunological phenotype of offspring. Brain Behav. Immun. 33, 33-45 (2013).
    • (2013) Brain Behav. Immun. , vol.33 , pp. 33-45
    • Mandal, M.1
  • 135
    • 84898543515 scopus 로고    scopus 로고
    • Maternal immune activation leads to activated inflammatory macrophages in offspring
    • Onore, C. E., Schwartzer, J. J., Careaga, M., Berman, R. F. & Ashwood, P. Maternal immune activation leads to activated inflammatory macrophages in offspring. Brain Behav. Immun. 38, 220-226 (2014).
    • (2014) Brain Behav. Immun. , vol.38 , pp. 220-226
    • Onore, C.E.1    Schwartzer, J.J.2    Careaga, M.3    Berman, R.F.4    Ashwood, P.5
  • 136
    • 60149103359 scopus 로고    scopus 로고
    • Elevated immune response in the brain of autistic patients
    • Li, X. et al. Elevated immune response in the brain of autistic patients. J. Neuroimmunol. 207, 111-116 (2009).
    • (2009) J. Neuroimmunol. , vol.207 , pp. 111-116
    • Li, X.1
  • 137
    • 79956040296 scopus 로고    scopus 로고
    • IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation
    • Wei, H. et al. IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation. J. Neuroinflammation 8, 52 (2011).
    • (2011) J. Neuroinflammation , vol.8 , pp. 52
    • Wei, H.1
  • 138
    • 77955684004 scopus 로고    scopus 로고
    • Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism
    • Morgan, J. T. et al. Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism. Biol. Psychiatry 68, 368-376 (2010).
    • (2010) Biol. Psychiatry , vol.68 , pp. 368-376
    • Morgan, J.T.1
  • 139
    • 84876487228 scopus 로고    scopus 로고
    • Microglia in the cerebral cortex in autism
    • Tetreault, N. A. et al. Microglia in the cerebral cortex in autism. J. Autism Dev. Disord. 42, 2569-2584 (2012).
    • (2012) J. Autism Dev. Disord. , vol.42 , pp. 2569-2584
    • Tetreault, N.A.1
  • 140
    • 0028171290 scopus 로고
    • Decrease in 6R-5,6,7,8-tetrahydrobiopterin content in cerebrospinal fluid of autistic patients
    • Tani, Y., Fernell, E., Watanabe, Y., Kanai, T. & Langstrom, B. Decrease in 6R-5,6,7,8-tetrahydrobiopterin content in cerebrospinal fluid of autistic patients. Neurosci. Lett. 181, 169-172 (1994).
    • (1994) Neurosci. Lett. , vol.181 , pp. 169-172
    • Tani, Y.1    Fernell, E.2    Watanabe, Y.3    Kanai, T.4    Langstrom, B.5
  • 141
    • 0029068833 scopus 로고
    • Cerebrospinal fluid biopterin and biogenic amine metabolites during oral R-THBP therapy for infantile autism
    • Komori, H. et al. Cerebrospinal fluid biopterin and biogenic amine metabolites during oral R-THBP therapy for infantile autism. J. Autism Dev. Disord. 25, 183-193 (1995).
    • (1995) J. Autism Dev. Disord. , vol.25 , pp. 183-193
    • Komori, H.1
  • 142
    • 27644586632 scopus 로고    scopus 로고
    • Cerebrospinal fluid and serum markers of inflammation in autism
    • Zimmerman, A. W. et al. Cerebrospinal fluid and serum markers of inflammation in autism. Pediatr. Neurol. 33, 195-201 (2005).
    • (2005) Pediatr. Neurol. , vol.33 , pp. 195-201
    • Zimmerman, A.W.1
  • 143
    • 84862208120 scopus 로고    scopus 로고
    • Maternal immune activation by poly I:C induces expression of cytokines IL-1β and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain
    • Arrode-Bruses, G. & Bruses, J. L. Maternal immune activation by poly I:C induces expression of cytokines IL-1β and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain. J. Neuroinflammation 9, 83 (2012).
    • (2012) J. Neuroinflammation , vol.9 , pp. 83
    • Arrode-Bruses, G.1    Bruses, J.L.2
  • 144
    • 33646926705 scopus 로고    scopus 로고
    • The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology
    • Meyer, U. et al. The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology. J. Neurosci. 26, 4752-4762 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 4752-4762
    • Meyer, U.1
  • 145
    • 84877352822 scopus 로고    scopus 로고
    • Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development
    • Garay, P. A., Hsiao, E. Y., Patterson, P. H. & McAllister, A. K. Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development. Brain Behav. Immun. 31, 54-68 (2013).
    • (2013) Brain Behav. Immun. , vol.31 , pp. 54-68
    • Garay, P.A.1    Hsiao, E.Y.2    Patterson, P.H.3    McAllister, A.K.4
  • 146
    • 84912050435 scopus 로고    scopus 로고
    • Alterations in immune cells and mediators in the brain: It's not always neuroinflammation!
    • Estes, M. L. & McAllister, A. K. Alterations in immune cells and mediators in the brain: it's not always neuroinflammation! Brain Pathol. 24, 623-630 (2014).
    • (2014) Brain Pathol. , vol.24 , pp. 623-630
    • Estes, M.L.1    McAllister, A.K.2
  • 148
    • 84863380407 scopus 로고    scopus 로고
    • The role of gut microbiota in immune homeostasis and autoimmunity
    • Wu, H. J. & Wu, E. The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes 3, 4-14 (2012).
    • (2012) Gut Microbes , vol.3 , pp. 4-14
    • Wu, H.J.1    Wu, E.2
  • 149
    • 79551686484 scopus 로고    scopus 로고
    • Microbiota-immune system interaction: An uneasy alliance
    • Salzman, N. H. Microbiota-immune system interaction: an uneasy alliance. Curr. Opin. Microbiol. 14, 99-105 (2011).
    • (2011) Curr. Opin. Microbiol. , vol.14 , pp. 99-105
    • Salzman, N.H.1
  • 150
    • 8744264007 scopus 로고    scopus 로고
    • Real-time PCR quantitation of clostridia in feces of autistic children
    • Song, Y., Liu, C. & Finegold, S. M. Real-time PCR quantitation of clostridia in feces of autistic children. Appl. Environ. Microbiol. 70, 6459-6465 (2004).
    • (2004) Appl. Environ. Microbiol. , vol.70 , pp. 6459-6465
    • Song, Y.1    Liu, C.2    Finegold, S.M.3
  • 151
    • 25844467765 scopus 로고    scopus 로고
    • Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children
    • Parracho, H. M., Bingham, M. O., Gibson, G. R. & McCartney, A. L. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J. Med. Microbiol. 54, 987-991 (2005).
    • (2005) J. Med. Microbiol. , vol.54 , pp. 987-991
    • Parracho, H.M.1    Bingham, M.O.2    Gibson, G.R.3    McCartney, A.L.4
  • 152
    • 79960629891 scopus 로고    scopus 로고
    • Desulfovibrio species are potentially important in regressive autism
    • Finegold, S. M. Desulfovibrio species are potentially important in regressive autism. Med. Hypotheses 77, 270-274 (2011).
    • (2011) Med. Hypotheses , vol.77 , pp. 270-274
    • Finegold, S.M.1
  • 153
    • 70349742524 scopus 로고    scopus 로고
    • The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
    • Gaboriau-Routhiau, V. et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 31, 677-689 (2009).
    • (2009) Immunity , vol.31 , pp. 677-689
    • Gaboriau-Routhiau, V.1
  • 154
    • 44949127290 scopus 로고    scopus 로고
    • Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells
    • Ishikawa, H. et al. Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells. Clin. Exp. Immunol. 153, 127-135 (2008).
    • (2008) Clin. Exp. Immunol. , vol.153 , pp. 127-135
    • Ishikawa, H.1
  • 155
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian, S. K., Liu, C. H., Tzianabos, A. O. & Kasper, D. L. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122, 107-118 (2005).
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 156
    • 78449231774 scopus 로고    scopus 로고
    • Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives
    • de Magistris, L. et al. Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. J. Pediatr. Gastroenterol. Nutr. 51, 418-424 (2010).
    • (2010) J. Pediatr. Gastroenterol. Nutr. , vol.51 , pp. 418-424
    • De Magistris, L.1
  • 157
    • 84868617840 scopus 로고    scopus 로고
    • Gastrointestinal conditions in children with autism spectrum disorder: Developing a research agenda
    • Coury, D. L. et al. Gastrointestinal conditions in children with autism spectrum disorder: developing a research agenda. Pediatrics 130 (Suppl. 2), S160-S168 (2012).
    • (2012) Pediatrics , vol.130 , pp. S160-S168
    • Coury, D.L.1
  • 158
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • Hsiao, E. Y. et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155, 1451-1463 (2013).
    • (2013) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1
  • 159
    • 84859816611 scopus 로고    scopus 로고
    • Microbiology of regressive autism
    • Finegold, S. M., Downes, J. & Summanen, P. H. Microbiology of regressive autism. Anaerobe 18, 260-262 (2012).
    • (2012) Anaerobe , vol.18 , pp. 260-262
    • Finegold, S.M.1    Downes, J.2    Summanen, P.H.3
  • 160
    • 70349838218 scopus 로고    scopus 로고
    • Cytokines and CNS development
    • Deverman, B. E. & Patterson, P. H. Cytokines and CNS development. Neuron 64, 61-78 (2009). An excellent review of the diverse and non-classical roles of cytokines in the developing brain.
    • (2009) Neuron , vol.64 , pp. 61-78
    • Deverman, B.E.1    Patterson, P.H.2
  • 161
    • 84862188749 scopus 로고    scopus 로고
    • Novel roles for immune molecules in neural development: Implications for neurodevelopmental disorders
    • Garay, P. A. & McAllister, A. K. Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders. Front. Synaptic Neurosci. 2, 136 (2010).
    • (2010) Front. Synaptic Neurosci. , vol.2 , pp. 136
    • Garay, P.A.1    McAllister, A.K.2
  • 162
    • 84875648076 scopus 로고    scopus 로고
    • Cytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment
    • Goines, P. E. & Ashwood, P. Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment. Neurotoxicol. Teratol. 36, 67-81 (2013).
    • (2013) Neurotoxicol. Teratol. , vol.36 , pp. 67-81
    • Goines, P.E.1    Ashwood, P.2
  • 163
    • 34247880436 scopus 로고    scopus 로고
    • Role of interleukin-1β in the control of neuroepithelial proliferation and differentiation of the spinal cord during development
    • de la Mano, A. et al. Role of interleukin-1β in the control of neuroepithelial proliferation and differentiation of the spinal cord during development. Cytokine 37, 128-137 (2007).
    • (2007) Cytokine , vol.37 , pp. 128-137
    • De La Mano, A.1
  • 164
    • 70350220725 scopus 로고    scopus 로고
    • IL1RAPL1 controls inhibitory networks during cerebellar development in mice
    • Gambino, F. et al. IL1RAPL1 controls inhibitory networks during cerebellar development in mice. Eur. J. Neurosci. 30, 1476-1486 (2009).
    • (2009) Eur. J. Neurosci. , vol.30 , pp. 1476-1486
    • Gambino, F.1
  • 165
    • 81855173451 scopus 로고    scopus 로고
    • The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2
    • Valnegri, P. et al. The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2. Hum. Mol. Genet. 20, 4797-4809 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 4797-4809
    • Valnegri, P.1
  • 166
    • 52049107819 scopus 로고    scopus 로고
    • Zebrafish orthologue of mental retardation protein IL1RAPL1 regulates presynaptic differentiation
    • Yoshida, T. & Mishina, M. Zebrafish orthologue of mental retardation protein IL1RAPL1 regulates presynaptic differentiation. Mol. Cell. Neurosci. 39, 218-228 (2008).
    • (2008) Mol. Cell. Neurosci. , vol.39 , pp. 218-228
    • Yoshida, T.1    Mishina, M.2
  • 167
    • 80053025841 scopus 로고    scopus 로고
    • IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ
    • Yoshida, T. et al. IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ. J. Neurosci. 31, 13485-13499 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 13485-13499
    • Yoshida, T.1
  • 168
    • 84863164032 scopus 로고    scopus 로고
    • Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule
    • Yoshida, T. et al. Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule. J. Neurosci. 32, 2588-2600 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 2588-2600
    • Yoshida, T.1
  • 169
    • 74849134916 scopus 로고    scopus 로고
    • A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation
    • Pavlowsky, A. et al. A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation. Curr. Biol. 20, 103-115 (2010).
    • (2010) Curr. Biol. , vol.20 , pp. 103-115
    • Pavlowsky, A.1
  • 170
    • 84882676787 scopus 로고    scopus 로고
    • Target-specific vulnerability of excitatory synapses leads to deficits in associative memory in a model of intellectual disorder
    • Houbaert, X. et al. Target-specific vulnerability of excitatory synapses leads to deficits in associative memory in a model of intellectual disorder. J. Neurosci. 33, 13805-13819 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 13805-13819
    • Houbaert, X.1
  • 171
    • 30644479042 scopus 로고    scopus 로고
    • Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome
    • Moretti, P. et al. Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. J. Neurosci. 26, 319-327 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 319-327
    • Moretti, P.1
  • 172
    • 58049190133 scopus 로고    scopus 로고
    • Interleukin-1 (IL-1): A central regulator of stress responses
    • Goshen, I. & Yirmiya, R. Interleukin-1 (IL-1): a central regulator of stress responses. Front. Neuroendocrinol. 30, 30-45 (2009).
    • (2009) Front. Neuroendocrinol. , vol.30 , pp. 30-45
    • Goshen, I.1    Yirmiya, R.2
  • 173
    • 55049114476 scopus 로고    scopus 로고
    • Tumor necrosis factor-α modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures
    • Bernardino, L. et al. Tumor necrosis factor-α modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures. Stem Cells 26, 2361-2371 (2008).
    • (2008) Stem Cells , vol.26 , pp. 2361-2371
    • Bernardino, L.1
  • 174
    • 84894049144 scopus 로고    scopus 로고
    • Neuroimmune regulation of homeostatic synaptic plasticity
    • Pribiag, H. & Stellwagen, D. Neuroimmune regulation of homeostatic synaptic plasticity. Neuropharmacology 78, 13-22 (2014).
    • (2014) Neuropharmacology , vol.78 , pp. 13-22
    • Pribiag, H.1    Stellwagen, D.2
  • 175
    • 84905055092 scopus 로고    scopus 로고
    • STAT1 regulates the homeostatic component of visual cortical plasticity via an AMPA receptor-mediated mechanism
    • Nagakura, I., Van Wart, A., Petravicz, J., Tropea, D. & Sur, M. STAT1 regulates the homeostatic component of visual cortical plasticity via an AMPA receptor-mediated mechanism. J. Neurosci. 34, 10256-10263 (2014).
    • (2014) J. Neurosci. , vol.34 , pp. 10256-10263
    • Nagakura, I.1    Van Wart, A.2    Petravicz, J.3    Tropea, D.4    Sur, M.5
  • 176
    • 33847351136 scopus 로고    scopus 로고
    • The JAK-STAT signaling pathway: Input and output integration
    • Murray, P. J. The JAK-STAT signaling pathway: input and output integration. J. Immunol. 178, 2623-2629 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 2623-2629
    • Murray, P.J.1
  • 177
    • 33745750936 scopus 로고    scopus 로고
    • Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex
    • Tropea, D. et al. Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex. Nat. Neurosci. 9, 660-668 (2006).
    • (2006) Nat. Neurosci. , vol.9 , pp. 660-668
    • Tropea, D.1
  • 178
    • 78650913822 scopus 로고    scopus 로고
    • Novel role and mechanism of protein inhibitor of activated STAT1 in spatial learning
    • Tai, D. J., Hsu, W. L., Liu, Y. C., Ma, Y. L. & Lee, E. H. Novel role and mechanism of protein inhibitor of activated STAT1 in spatial learning. EMBO J. 30, 205-220 (2011).
    • (2011) EMBO J. , vol.30 , pp. 205-220
    • Tai, D.J.1    Hsu, W.L.2    Liu, Y.C.3    Ma, Y.L.4    Lee, E.H.5
  • 179
    • 77950187447 scopus 로고    scopus 로고
    • Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
    • Feng, J. et al. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat. Neurosci. 13, 423-430 (2010).
    • (2010) Nat. Neurosci. , vol.13 , pp. 423-430
    • Feng, J.1
  • 180
    • 84863012554 scopus 로고    scopus 로고
    • The Jak/STAT pathway is involved in synaptic plasticity
    • Nicolas, C. S. et al. The Jak/STAT pathway is involved in synaptic plasticity. Neuron 73, 374-390 (2012).
    • (2012) Neuron , vol.73 , pp. 374-390
    • Nicolas, C.S.1
  • 181
    • 64549151568 scopus 로고    scopus 로고
    • Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain
    • Judson, M. C., Bergman, M. Y., Campbell, D. B., Eagleson, K. L. & Levitt, P. Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain. J. Comp. Neurol. 513, 511-531 (2009).
    • (2009) J. Comp. Neurol. , vol.513 , pp. 511-531
    • Judson, M.C.1    Bergman, M.Y.2    Campbell, D.B.3    Eagleson, K.L.4    Levitt, P.5
  • 182
    • 0037069472 scopus 로고    scopus 로고
    • Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development
    • Ieraci, A., Forni, P. E. & Ponzetto, C. Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development. Proc. Natl Acad. Sci. USA 99, 15200-15205 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 15200-15205
    • Ieraci, A.1    Forni, P.E.2    Ponzetto, C.3
  • 183
    • 84879162485 scopus 로고    scopus 로고
    • Prenatal expression of MET receptor tyrosine kinase in the fetal mouse dorsal raphe nuclei and the visceral motor/sensory brainstem
    • Wu, H. H. & Levitt, P. Prenatal expression of MET receptor tyrosine kinase in the fetal mouse dorsal raphe nuclei and the visceral motor/sensory brainstem. Dev. Neurosci. 35, 1-16 (2013).
    • (2013) Dev. Neurosci. , vol.35 , pp. 1-16
    • Wu, H.H.1    Levitt, P.2
  • 184
    • 84881237360 scopus 로고    scopus 로고
    • Synaptic and extrasynaptic location of the receptor tyrosine kinase Met during postnatal development in the mouse neocortex and hippocampus
    • Eagleson, K. L., Milner, T. A., Xie, Z. & Levitt, P. Synaptic and extrasynaptic location of the receptor tyrosine kinase Met during postnatal development in the mouse neocortex and hippocampus. J. Comp. Neurol. 521, 3241-3259 (2013).
    • (2013) J. Comp. Neurol. , vol.521 , pp. 3241-3259
    • Eagleson, K.L.1    Milner, T.A.2    Xie, Z.3    Levitt, P.4
  • 185
    • 33746225421 scopus 로고    scopus 로고
    • The receptor tyrosine kinase Met and its ligand hepatocyte growth factor are clustered at excitatory synapses and can enhance clustering of synaptic proteins
    • Tyndall, S. J. & Walikonis, R. S. The receptor tyrosine kinase Met and its ligand hepatocyte growth factor are clustered at excitatory synapses and can enhance clustering of synaptic proteins. Cell Cycle 5, 1560-1568 (2006).
    • (2006) Cell Cycle , vol.5 , pp. 1560-1568
    • Tyndall, S.J.1    Walikonis, R.S.2
  • 186
    • 34548727498 scopus 로고    scopus 로고
    • Hepatocyte growth factor promotes the number of PSD-95 clusters in young hippocampal neurons
    • Nakano, M. et al. Hepatocyte growth factor promotes the number of PSD-95 clusters in young hippocampal neurons. Exp. Neurol. 207, 195-202 (2007).
    • (2007) Exp. Neurol. , vol.207 , pp. 195-202
    • Nakano, M.1
  • 188
    • 39849088412 scopus 로고    scopus 로고
    • Hepatocyte growth factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway
    • Lim, C. S. & Walikonis, R. S. Hepatocyte growth factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway. Cell. Signal. 20, 825-835 (2008).
    • (2008) Cell. Signal. , vol.20 , pp. 825-835
    • Lim, C.S.1    Walikonis, R.S.2
  • 189
    • 4344680065 scopus 로고    scopus 로고
    • Hepatocyte growth factor as an enhancer of NMDA currents and synaptic plasticity in the hippocampus
    • Akimoto, M. et al. Hepatocyte growth factor as an enhancer of NMDA currents and synaptic plasticity in the hippocampus. Neuroscience 128, 155-162 (2004).
    • (2004) Neuroscience , vol.128 , pp. 155-162
    • Akimoto, M.1
  • 190
    • 79955763971 scopus 로고    scopus 로고
    • Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase
    • Qiu, S., Anderson, C. T., Levitt, P. & Shepherd, G. M. Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase. J. Neurosci. 31, 5855-5864 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 5855-5864
    • Qiu, S.1    Anderson, C.T.2    Levitt, P.3    Shepherd, G.M.4
  • 191
    • 84882620367 scopus 로고    scopus 로고
    • MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease
    • Elmer, B. M., Estes, M. L., Barrow, S. L. & McAllister, A. K. MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease. J. Neurosci. 33, 13791-13804 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 13791-13804
    • Elmer, B.M.1    Estes, M.L.2    Barrow, S.L.3    McAllister, A.K.4
  • 192
    • 0032168898 scopus 로고    scopus 로고
    • Regulation of class I MHC gene expression in the developing and mature CNS by neural activity
    • Corriveau, R. A., Huh, G. S. & Shatz, C. J. Regulation of class I MHC gene expression in the developing and mature CNS by neural activity. Neuron 21, 505-520 (1998).
    • (1998) Neuron , vol.21 , pp. 505-520
    • Corriveau, R.A.1    Huh, G.S.2    Shatz, C.J.3
  • 193
    • 84867916817 scopus 로고    scopus 로고
    • Major histocompatibility complex class I proteins in brain development and plasticity
    • Elmer, B. M. & McAllister, A. K. Major histocompatibility complex class I proteins in brain development and plasticity. Trends Neurosci. 35, 660-670 (2012).
    • (2012) Trends Neurosci. , vol.35 , pp. 660-670
    • Elmer, B.M.1    McAllister, A.K.2
  • 194
    • 84899426320 scopus 로고    scopus 로고
    • Synapse elimination and learning rules co-regulated by MHC class I H2-Db
    • Lee, H. et al. Synapse elimination and learning rules co-regulated by MHC class I H2-Db. Nature 509, 195-200 (2014).
    • (2014) Nature , vol.509 , pp. 195-200
    • Lee, H.1
  • 195
    • 34249849030 scopus 로고    scopus 로고
    • Regulation of CNS synapses by neuronal MHC class I
    • Goddard, C. A., Butts, D. A. & Shatz, C. J. Regulation of CNS synapses by neuronal MHC class I. Proc. Natl Acad. Sci. USA 104, 6828-6833 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 6828-6833
    • Goddard, C.A.1    Butts, D.A.2    Shatz, C.J.3
  • 196
    • 78049278778 scopus 로고    scopus 로고
    • MHC class I molecules are present both pre- and postsynaptically in the visual cortex during postnatal development and in adulthood
    • Needleman, L. A., Liu, X. B., El-Sabeawy, F., Jones, E. G. & McAllister, A. K. MHC class I molecules are present both pre- and postsynaptically in the visual cortex during postnatal development and in adulthood. Proc. Natl Acad. Sci. USA 107, 16999-17004 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 16999-17004
    • Needleman, L.A.1    Liu, X.B.2    El-Sabeawy, F.3    Jones, E.G.4    McAllister, A.K.5
  • 197
    • 79953191735 scopus 로고    scopus 로고
    • MHCI negatively regulates synapse density during the establishment of cortical connections
    • Glynn, M. W. et al. MHCI negatively regulates synapse density during the establishment of cortical connections. Nat. Neurosci. 14, 442-451 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 442-451
    • Glynn, M.W.1
  • 198
    • 78650666371 scopus 로고    scopus 로고
    • MHC class I modulates NMDA receptor function and AMPA receptor trafficking
    • Fourgeaud, L. et al. MHC class I modulates NMDA receptor function and AMPA receptor trafficking. Proc. Natl Acad. Sci. USA 107, 22278-22283 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 22278-22283
    • Fourgeaud, L.1
  • 199
    • 0034671891 scopus 로고    scopus 로고
    • Functional requirement for class I MHC in CNS development and plasticity
    • Huh, G. S. et al. Functional requirement for class I MHC in CNS development and plasticity. Science 290, 2155-2159 (2000).
    • (2000) Science , vol.290 , pp. 2155-2159
    • Huh, G.S.1
  • 200
    • 84883421597 scopus 로고    scopus 로고
    • MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression
    • Nelson, P. A. et al. MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression. Learn. Mem. 20, 505-517 (2013).
    • (2013) Learn. Mem. , vol.20 , pp. 505-517
    • Nelson, P.A.1
  • 201
    • 57649211993 scopus 로고    scopus 로고
    • Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection
    • Flavell, S. W. et al. Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection. Neuron 60, 1022-1038 (2008).
    • (2008) Neuron , vol.60 , pp. 1022-1038
    • Flavell, S.W.1
  • 202
    • 33144467591 scopus 로고    scopus 로고
    • Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number
    • Flavell, S. W. et al. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science 311, 1008-1012 (2006).
    • (2006) Science , vol.311 , pp. 1008-1012
    • Flavell, S.W.1
  • 203
    • 84877765743 scopus 로고    scopus 로고
    • MEF2C haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways
    • Paciorkowski, A. R. et al. MEF2C haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways. Neurogenetics 14, 99-111 (2013).
    • (2013) Neurogenetics , vol.14 , pp. 99-111
    • Paciorkowski, A.R.1
  • 204
    • 35148885611 scopus 로고    scopus 로고
    • Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism
    • Martin, C. L. et al. Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism. Am. J.Med. Genet. B Neuropsychiatr. Genet. 144B, 869-876 (2007).
    • (2007) Am. J.Med. Genet. B Neuropsychiatr. Genet. , vol.144 B , pp. 869-876
    • Martin, C.L.1
  • 205
    • 74249116056 scopus 로고    scopus 로고
    • Copy number and sequence variants implicate APBA2 as an autism candidate gene
    • Babatz, T. D., Kumar, R. A., Sudi, J., Dobyns, W. B. & Christian, S. L. Copy number and sequence variants implicate APBA2 as an autism candidate gene. Autism Res. 2, 359-364 (2009).
    • (2009) Autism Res. , vol.2 , pp. 359-364
    • Babatz, T.D.1    Kumar, R.A.2    Sudi, J.3    Dobyns, W.B.4    Christian, S.L.5
  • 206
    • 84889561601 scopus 로고    scopus 로고
    • Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism
    • Parikshak, N. N. et al. Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. Cell 155, 1008-1021 (2013).
    • (2013) Cell , vol.155 , pp. 1008-1021
    • Parikshak, N.N.1
  • 207
    • 84876313659 scopus 로고    scopus 로고
    • Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity
    • Zang, T. et al. Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity. Mol. Cell. Neurosci. 56, 39-49 (2013).
    • (2013) Mol. Cell. Neurosci. , vol.56 , pp. 39-49
    • Zang, T.1
  • 208
    • 84871563278 scopus 로고    scopus 로고
    • Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95
    • Tsai, N. P. et al. Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell 151, 1581-1594 (2012).
    • (2012) Cell , vol.151 , pp. 1581-1594
    • Tsai, N.P.1
  • 209
    • 84872593582 scopus 로고    scopus 로고
    • Activity-dependent neuronal signalling and autism spectrum disorder
    • Ebert, D. H. & Greenberg, M. E. Activity-dependent neuronal signalling and autism spectrum disorder. Nature 493, 327-337 (2013).
    • (2013) Nature , vol.493 , pp. 327-337
    • Ebert, D.H.1    Greenberg, M.E.2
  • 210
    • 84860611251 scopus 로고    scopus 로고
    • Abnormal microglial-neuronal spatial organization in the dorsolateral prefrontal cortex in autism
    • Morgan, J. T. et al. Abnormal microglial-neuronal spatial organization in the dorsolateral prefrontal cortex in autism. Brain Res. 1456, 72-81 (2012).
    • (2012) Brain Res. , vol.1456 , pp. 72-81
    • Morgan, J.T.1
  • 211
    • 84871939639 scopus 로고    scopus 로고
    • Microglial activation in young adults with autism spectrum disorder
    • Suzuki, K. et al. Microglial activation in young adults with autism spectrum disorder. JAMA Psychiatry 70, 49-58 (2013).
    • (2013) JAMA Psychiatry , vol.70 , pp. 49-58
    • Suzuki, K.1
  • 212
    • 84899418705 scopus 로고    scopus 로고
    • Microglia and brain macrophages in the molecular age: From origin to neuropsychiatric disease
    • Prinz, M. & Priller, J. Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat. Rev. Neurosci. 15, 300-312 (2014).
    • (2014) Nat. Rev. Neurosci. , vol.15 , pp. 300-312
    • Prinz, M.1    Priller, J.2
  • 213
    • 30044434850 scopus 로고    scopus 로고
    • Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells
    • Butovsky, O. et al. Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol. Cell. Neurosci. 31, 149-160 (2006).
    • (2006) Mol. Cell. Neurosci. , vol.31 , pp. 149-160
    • Butovsky, O.1
  • 214
    • 84874586343 scopus 로고    scopus 로고
    • Microglia regulate the number of neural precursor cells in the developing cerebral cortex
    • Cunningham, C. L., Martinez-Cerdeno, V. & Noctor, S. C. Microglia regulate the number of neural precursor cells in the developing cerebral cortex. J. Neurosci. 33, 4216-4233 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 4216-4233
    • Cunningham, C.L.1    Martinez-Cerdeno, V.2    Noctor, S.C.3
  • 215
    • 84869157553 scopus 로고    scopus 로고
    • The "quad-partite" synapse: Microglia-synapse interactions in the developing and mature CNS
    • Schafer, D. P., Lehrman, E. K. & Stevens, B. The "quad-partite" synapse: microglia-synapse interactions in the developing and mature CNS. Glia 61, 24-36 (2013).
    • (2013) Glia , vol.61 , pp. 24-36
    • Schafer, D.P.1    Lehrman, E.K.2    Stevens, B.3
  • 216
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • Paolicelli, R. C. et al. Synaptic pruning by microglia is necessary for normal brain development. Science 333, 1456-1458 (2011).
    • (2011) Science , vol.333 , pp. 1456-1458
    • Paolicelli, R.C.1
  • 217
    • 84896692474 scopus 로고    scopus 로고
    • Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior
    • Zhan, Y. et al. Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nat. Neurosci. 17, 400-406 (2014).
    • (2014) Nat. Neurosci. , vol.17 , pp. 400-406
    • Zhan, Y.1
  • 218
    • 13444293140 scopus 로고    scopus 로고
    • Confirmation of the association of the C4B null allelle in autism
    • Odell, D. et al. Confirmation of the association of the C4B null allelle in autism. Hum. Immunol. 66, 140-145 (2005).
    • (2005) Hum. Immunol. , vol.66 , pp. 140-145
    • Odell, D.1
  • 219
    • 37349066319 scopus 로고    scopus 로고
    • Complement deficiencies and systemic lupus erythematosus
    • Truedsson, L., Bengtsson, A. A. & Sturfelt, G. Complement deficiencies and systemic lupus erythematosus. Autoimmunity 40, 560-566 (2007).
    • (2007) Autoimmunity , vol.40 , pp. 560-566
    • Truedsson, L.1    Bengtsson, A.A.2    Sturfelt, G.3
  • 220
    • 36849076770 scopus 로고    scopus 로고
    • The classical complement cascade mediates CNS synapse elimination
    • Stevens, B. et al. The classical complement cascade mediates CNS synapse elimination. Cell 131, 1164-1178 (2007).
    • (2007) Cell , vol.131 , pp. 1164-1178
    • Stevens, B.1
  • 221
    • 5144222255 scopus 로고    scopus 로고
    • Complement: A unique innate immune sensor for danger signals
    • Gasque, P. Complement: a unique innate immune sensor for danger signals. Mol. Immunol. 41, 1089-1098 (2004).
    • (2004) Mol. Immunol. , vol.41 , pp. 1089-1098
    • Gasque, P.1
  • 222
    • 84861427387 scopus 로고    scopus 로고
    • Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
    • Schafer, D. P. et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74, 691-705 (2012).
    • (2012) Neuron , vol.74 , pp. 691-705
    • Schafer, D.P.1
  • 223
    • 84888348687 scopus 로고    scopus 로고
    • TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement
    • Bialas, A. R. & Stevens, B. TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat. Neurosci. 16, 1773-1782 (2013).
    • (2013) Nat. Neurosci. , vol.16 , pp. 1773-1782
    • Bialas, A.R.1    Stevens, B.2
  • 224
    • 84878262522 scopus 로고    scopus 로고
    • Beach award: Programming of neuroendocrine function by early-life experience: A critical role for the immune system
    • Bilbo, S. D. & Frank, A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system. Horm. Behav. 63, 684-691 (2013).
    • (2013) Horm. Behav. , vol.63 , pp. 684-691
    • Bilbo, S.D.1    Frank, A.2
  • 225
    • 0037315747 scopus 로고    scopus 로고
    • The impact of systemic infection on the progression of neurodegenerative disease
    • Perry, V. H., Newman, T. A. & Cunningham, C. The impact of systemic infection on the progression of neurodegenerative disease. Nat. Rev. Neurosci. 4, 103-112 (2003).
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 103-112
    • Perry, V.H.1    Newman, T.A.2    Cunningham, C.3
  • 227
    • 84886826594 scopus 로고    scopus 로고
    • mTOR complexes in neurodevelopmental and neuropsychiatric disorders
    • Costa-Mattioli, M. & Monteggia, L. M. mTOR complexes in neurodevelopmental and neuropsychiatric disorders. Nat. Neurosci. 16, 1537-1543 (2013).
    • (2013) Nat. Neurosci. , vol.16 , pp. 1537-1543
    • Costa-Mattioli, M.1    Monteggia, L.M.2
  • 228
    • 84899144736 scopus 로고    scopus 로고
    • mTOR signaling and its roles in normal and abnormal brain development
    • Takei, N. & Nawa, H. mTOR signaling and its roles in normal and abnormal brain development. Front. Mol. Neurosci. 7, 28 (2014).
    • (2014) Front. Mol. Neurosci. , vol.7 , pp. 28
    • Takei, N.1    Nawa, H.2
  • 229
    • 84902315089 scopus 로고    scopus 로고
    • Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases
    • Kassai, H. et al. Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell Rep. 7, 1626-1639 (2014).
    • (2014) Cell Rep. , vol.7 , pp. 1626-1639
    • Kassai, H.1
  • 231
    • 79952032711 scopus 로고    scopus 로고
    • Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model
    • Ricciardi, S. et al. Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model. Hum. Mol. Genet. 20, 1182-1196 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 1182-1196
    • Ricciardi, S.1
  • 232
    • 77957847881 scopus 로고    scopus 로고
    • Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease
    • Qin, S. et al. Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease. J. Clin. Invest. 120, 3617-3628 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 3617-3628
    • Qin, S.1
  • 233
    • 84859454582 scopus 로고    scopus 로고
    • Wild-type microglia arrest pathology in a mouse model of Rett syndrome
    • Derecki, N. C. et al. Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature 484, 105-109 (2012).
    • (2012) Nature , vol.484 , pp. 105-109
    • Derecki, N.C.1
  • 234
    • 84884215708 scopus 로고    scopus 로고
    • Autologous bone marrow mononuclear cell therapy for autism: An open label proof of concept study
    • Sharma, A. et al. Autologous bone marrow mononuclear cell therapy for autism: an open label proof of concept study. Stem Cells Int. 2013, 623875 (2013).
    • (2013) Stem Cells Int. , vol.2013 , pp. 623875
    • Sharma, A.1
  • 235
    • 84883077674 scopus 로고    scopus 로고
    • Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism
    • Lv, Y. T. et al. Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism. J. Translat. Med. 11, 196 (2013).
    • (2013) J. Translat. Med. , vol.11 , pp. 196
    • Lv, Y.T.1
  • 236
    • 62149089881 scopus 로고    scopus 로고
    • Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model
    • Bilousova, T. V. et al. Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model. J. Med. Genet. 46, 94-102 (2009).
    • (2009) J. Med. Genet. , vol.46 , pp. 94-102
    • Bilousova, T.V.1
  • 237
    • 84856596122 scopus 로고    scopus 로고
    • Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of fragile X syndrome
    • Rotschafer, S. E., Trujillo, M. S., Dansie, L. E., Ethell, I. M. & Razak, K. A. Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of fragile X syndrome. Brain Res. 1439, 7-14 (2012).
    • (2012) Brain Res. , vol.1439 , pp. 7-14
    • Rotschafer, S.E.1    Trujillo, M.S.2    Dansie, L.E.3    Ethell, I.M.4    Razak, K.A.5
  • 238
    • 84876358587 scopus 로고    scopus 로고
    • A randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with fragile X syndrome
    • Leigh, M. J. et al. A randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with fragile X syndrome. J. Dev. Behav. Pediatr. 34, 147-155 (2013).
    • (2013) J. Dev. Behav. Pediatr. , vol.34 , pp. 147-155
    • Leigh, M.J.1
  • 239
    • 7444237570 scopus 로고    scopus 로고
    • A pilot study of D-cycloserine in subjects with autistic disorder
    • Posey, D. J. et al. A pilot study of D-cycloserine in subjects with autistic disorder. Am. J. Psychiatry 161, 2115-2117 (2004).
    • (2004) Am. J. Psychiatry , vol.161 , pp. 2115-2117
    • Posey, D.J.1
  • 240
    • 0033929819 scopus 로고    scopus 로고
    • Short-term benefit from oral vancomycin treatment of regressive-onset autism
    • Sandler, R. H. et al. Short-term benefit from oral vancomycin treatment of regressive-onset autism. J. Child Neurol. 15, 429-435 (2000).
    • (2000) J. Child Neurol. , vol.15 , pp. 429-435
    • Sandler, R.H.1
  • 241
    • 84902528837 scopus 로고    scopus 로고
    • Improvements in behavioral symptoms following antibiotic therapy in a 14-year-old male with autism
    • Ramirez, P. L., Barnhill, K., Gutierrez, A., Schutte, C. & Hewitson, L. Improvements in behavioral symptoms following antibiotic therapy in a 14-year-old male with autism. Case Rep. Psychiatry 2013, 239034 (2013).
    • (2013) Case Rep. Psychiatry , vol.2013
    • Ramirez, P.L.1    Barnhill, K.2    Gutierrez, A.3    Schutte, C.4    Hewitson, L.5
  • 242
    • 84878794662 scopus 로고    scopus 로고
    • A pilot open-label trial of minocycline in patients with autism and regressive features
    • Pardo, C. A. et al. A pilot open-label trial of minocycline in patients with autism and regressive features. J. Neurodev. Disord. 5, 9 (2013).
    • (2013) J. Neurodev. Disord. , vol.5 , pp. 9
    • Pardo, C.A.1
  • 243
    • 84893271949 scopus 로고    scopus 로고
    • Minocycline inhibits angiogenesis in vitro through the translational suppression of HIF-1α
    • Jung, H. J. et al. Minocycline inhibits angiogenesis in vitro through the translational suppression of HIF-1α. Arch. Biochem. Biophys. 545, 74-82 (2014).
    • (2014) Arch. Biochem. Biophys. , vol.545 , pp. 74-82
    • Jung, H.J.1
  • 244
    • 0018888677 scopus 로고
    • Why do autistic children...?
    • Sullivan, R. C. Why do autistic children...? J. Autism Dev. Disord. 10, 231-241 (1980).
    • (1980) J. Autism Dev. Disord. , vol.10 , pp. 231-241
    • Sullivan, R.C.1
  • 245
    • 0022420348 scopus 로고
    • Fever in autistics
    • Cotterill, R. M. Fever in autistics. Nature 313, 426 (1985).
    • (1985) Nature , vol.313 , pp. 426
    • Cotterill, R.M.1
  • 246
    • 36849075732 scopus 로고    scopus 로고
    • Behaviors associated with fever in children with autism spectrum disorders
    • Curran, L. K. et al. Behaviors associated with fever in children with autism spectrum disorders. Pediatrics 120, e1386-e1392 (2007).
    • (2007) Pediatrics , vol.120 , pp. e1386-e1392
    • Curran, L.K.1
  • 247
    • 84902006302 scopus 로고    scopus 로고
    • Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy
    • Naviaux, J. C. et al. Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy. Transl Psychiatry 4, e400 (2014).
    • (2014) Transl Psychiatry , vol.4 , pp. e400
    • Naviaux, J.C.1
  • 248
    • 84924167753 scopus 로고    scopus 로고
    • Antipurinergic therapy corrects the autism-like features in the fragile X (Fmr1 knockout) mouse model
    • Naviaux, J. C. et al. Antipurinergic therapy corrects the autism-like features in the fragile X (Fmr1 knockout) mouse model. Mol. Autism 6, 1 (2015).
    • (2015) Mol. Autism , vol.6 , pp. 1
    • Naviaux, J.C.1
  • 250
    • 84893554183 scopus 로고    scopus 로고
    • T cells in the central nervous system: Messengers of destruction or purveyors of protection?
    • Walsh, J. T., Watson, N. & Kipnis, J. T cells in the central nervous system: messengers of destruction or purveyors of protection? Immunology 141, 340-344 (2014).
    • (2014) Immunology , vol.141 , pp. 340-344
    • Walsh, J.T.1    Watson, N.2    Kipnis, J.3
  • 251
    • 2542596271 scopus 로고    scopus 로고
    • T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions
    • Kipnis, J., Cohen, H., Cardon, M., Ziv, Y. & Schwartz, M. T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. Proc. Natl Acad. Sci. USA 101, 8180-8185 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 8180-8185
    • Kipnis, J.1    Cohen, H.2    Cardon, M.3    Ziv, Y.4    Schwartz, M.5
  • 252
    • 84890341272 scopus 로고    scopus 로고
    • + T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice
    • + T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice. Transl Psychiatry 3, e280 (2013).
    • (2013) Transl Psychiatry , vol.3 , pp. e280
    • Rattazzi, L.1
  • 253
    • 46049087379 scopus 로고    scopus 로고
    • Adaptive immunity affects learning behavior in mice
    • Brynskikh, A., Warren, T., Zhu, J. & Kipnis, J. Adaptive immunity affects learning behavior in mice. Brain Behav. Immun. 22, 861-869 (2008).
    • (2008) Brain Behav. Immun. , vol.22 , pp. 861-869
    • Brynskikh, A.1    Warren, T.2    Zhu, J.3    Kipnis, J.4
  • 254
    • 54249137250 scopus 로고    scopus 로고
    • Age-dependent spatial memory loss can be partially restored by immune activation
    • Ron-Harel, N. et al. Age-dependent spatial memory loss can be partially restored by immune activation. Rejuven. Res. 11, 903-913 (2008).
    • (2008) Rejuven. Res. , vol.11 , pp. 903-913
    • Ron-Harel, N.1
  • 255
    • 84888880129 scopus 로고    scopus 로고
    • + T cells are sufficient to support learning behavior in mice with limited T cell repertoire
    • + T cells are sufficient to support learning behavior in mice with limited T cell repertoire. Brain Behav. Immun. 35, 58-63 (2014).
    • (2014) Brain Behav. Immun. , vol.35 , pp. 58-63
    • Radjavi, A.1    Smirnov, I.2    Kipnis, J.3
  • 256
    • 79551685206 scopus 로고    scopus 로고
    • Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice
    • Derecki, N. C., Quinnies, K. M. & Kipnis, J. Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice. Brain Behav. Immun. 25, 379-385 (2011).
    • (2011) Brain Behav. Immun. , vol.25 , pp. 379-385
    • Derecki, N.C.1    Quinnies, K.M.2    Kipnis, J.3
  • 257
    • 84898722334 scopus 로고    scopus 로고
    • Heterogeneity and convergence: The synaptic pathophysiology of autism
    • Baudouin, S. J. Heterogeneity and convergence: the synaptic pathophysiology of autism. Eur. J. Neurosci. 39, 1107-1113 (2014).
    • (2014) Eur. J. Neurosci. , vol.39 , pp. 1107-1113
    • Baudouin, S.J.1
  • 258
    • 79954610221 scopus 로고    scopus 로고
    • Modeling autistic features in animals
    • Patterson, P. H. Modeling autistic features in animals. Pediat. Res. 69, 34R-40R (2011).
    • (2011) Pediat. Res. , vol.69 , pp. 34R-40R
    • Patterson, P.H.1
  • 259
    • 84874355139 scopus 로고    scopus 로고
    • Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice
    • Giovanoli, S. et al. Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice. Science 339, 1095-1099 (2013).
    • (2013) Science , vol.339 , pp. 1095-1099
    • Giovanoli, S.1
  • 261
    • 82555167069 scopus 로고    scopus 로고
    • Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines
    • Schmitz, M. L., Weber, A., Roxlau, T., Gaestel, M. & Kracht, M. Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines. Biochim. Biophys. Acta 1813, 2165-2175 (2011).
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 2165-2175
    • Schmitz, M.L.1    Weber, A.2    Roxlau, T.3    Gaestel, M.4    Kracht, M.5
  • 262
    • 0035380308 scopus 로고    scopus 로고
    • Pro- versus anti-inflammatory cytokines: Myth or reality
    • Cavaillon, J. M. Pro- versus anti-inflammatory cytokines: myth or reality. Cell. Mol. Biol. 47, 695-702 (2001).
    • (2001) Cell. Mol. Biol. , vol.47 , pp. 695-702
    • Cavaillon, J.M.1
  • 263
    • 78651412528 scopus 로고    scopus 로고
    • Immune modulation of learning, memory, neural plasticity and neurogenesis
    • Yirmiya, R. & Goshen, I. Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav. Immun. 25, 181-213 (2011).
    • (2011) Brain Behav. Immun. , vol.25 , pp. 181-213
    • Yirmiya, R.1    Goshen, I.2
  • 264
    • 77950013567 scopus 로고    scopus 로고
    • Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease
    • Schwartz, M. & Shechter, R. Protective autoimmunity functions by intracranial immunosurveillance to support the mind: the missing link between health and disease. Mol. Psychiatry 15, 342-354 (2010).
    • (2010) Mol. Psychiatry , vol.15 , pp. 342-354
    • Schwartz, M.1    Shechter, R.2
  • 265
    • 84890986568 scopus 로고    scopus 로고
    • Neurogenic neuroinflammation: Inflammatory CNS reactions in response to neuronal activity
    • Xanthos, D. N. & Sandkuhler, J. Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity. Nat. Rev. Neurosci. 15, 43-53 (2014).
    • (2014) Nat. Rev. Neurosci. , vol.15 , pp. 43-53
    • Xanthos, D.N.1    Sandkuhler, J.2
  • 266
    • 84930203800 scopus 로고    scopus 로고
    • Wild-type microglia do not reverse pathology in mouse models of Rett syndrome
    • Wang, J. et al. Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature 521, E1-E4 (2015).
    • (2015) Nature , vol.521 , pp. E1-E4
    • Wang, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.