메뉴 건너뛰기




Volumn 9, Issue , 2012, Pages

L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: The 'collusion' hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

Author keywords

Astrocytes; Hemichannel; Inflammation; L glutamate; Microglia; Transporter

Indexed keywords

CARBENOXOLONE; GLUTAMIC ACID; LIPOPOLYSACCHARIDE;

EID: 84874014729     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-275     Document Type: Article
Times cited : (139)

References (46)
  • 1
    • 77049101945 scopus 로고    scopus 로고
    • Cell death mechanisms in the early stages of acute glutamate neurotoxicity
    • 10.1016/j.neures.2009.11.009, 19944120
    • Kumar A, Singh RL, Babu GN. Cell death mechanisms in the early stages of acute glutamate neurotoxicity. Neurosci Res 2010, 66:271-278. 10.1016/j.neures.2009.11.009, 19944120.
    • (2010) Neurosci Res , vol.66 , pp. 271-278
    • Kumar, A.1    Singh, R.L.2    Babu, G.N.3
  • 2
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • 10.1016/0896-6273(88)90162-6, 2908446
    • Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988, 1:623-634. 10.1016/0896-6273(88)90162-6, 2908446.
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 5
    • 0029435316 scopus 로고
    • Excitotoxicity and neurodegeneration in amyotrophic lateral sclerosis
    • Rothstein JD. Excitotoxicity and neurodegeneration in amyotrophic lateral sclerosis. Clin Neurosci 1995-1996, 3:348-359.
    • (1995) Clin Neurosci , vol.3 , pp. 348-359
    • Rothstein, J.D.1
  • 7
    • 33846217457 scopus 로고    scopus 로고
    • Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement
    • 2013845, 17088867
    • Beart PM, O'Shea RD. Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement. Br J Pharmacol 2007, 150:5-17. 2013845, 17088867.
    • (2007) Br J Pharmacol , vol.150 , pp. 5-17
    • Beart, P.M.1    O'Shea, R.D.2
  • 8
    • 74449091642 scopus 로고    scopus 로고
    • Abnormal expressions of glutamate transporters and metabotropic glutamate receptor 1 in the spontaneously epileptic rat hippocampus
    • 10.1016/j.brainresbull.2009.10.008, 19853022
    • Guo F, Sun F, Yu JL, Wang QH, Tu DY, Mao XY, Liu R, Wu KC, Xie N, Hao LY, Cai JQ. Abnormal expressions of glutamate transporters and metabotropic glutamate receptor 1 in the spontaneously epileptic rat hippocampus. Brain Res Bull 2010, 81:510-516. 10.1016/j.brainresbull.2009.10.008, 19853022.
    • (2010) Brain Res Bull , vol.81 , pp. 510-516
    • Guo, F.1    Sun, F.2    Yu, J.L.3    Wang, Q.H.4    Tu, D.Y.5    Mao, X.Y.6    Liu, R.7    Wu, K.C.8    Xie, N.9    Hao, L.Y.10    Cai, J.Q.11
  • 9
    • 38649112650 scopus 로고    scopus 로고
    • Focal reduction of neuronal glutamate transporters in human neocortical epilepsy
    • 10.1111/j.1528-1167.2007.01310.x, 17868051
    • Rakhade SN, Loeb JA. Focal reduction of neuronal glutamate transporters in human neocortical epilepsy. Epilepsia 2008, 49:226-236. 10.1111/j.1528-1167.2007.01310.x, 17868051.
    • (2008) Epilepsia , vol.49 , pp. 226-236
    • Rakhade, S.N.1    Loeb, J.A.2
  • 11
    • 70350654793 scopus 로고    scopus 로고
    • Neuro-inflammation induced in the hippocampus of 'binge drinking' rats may be mediated by elevated extracellular glutamate content
    • 10.1111/j.1471-4159.2009.06389.x, 19765190
    • Ward RJ, Colivicchi MA, Allen R, Schol F, Lallemand F, de Witte P, Ballini C, Corte LD, Dexter D. Neuro-inflammation induced in the hippocampus of 'binge drinking' rats may be mediated by elevated extracellular glutamate content. J Neurochem 2009, 111:1119-1128. 10.1111/j.1471-4159.2009.06389.x, 19765190.
    • (2009) J Neurochem , vol.111 , pp. 1119-1128
    • Ward, R.J.1    Colivicchi, M.A.2    Allen, R.3    Schol, F.4    Lallemand, F.5    de Witte, P.6    Ballini, C.7    Corte, L.D.8    Dexter, D.9
  • 13
    • 59649115254 scopus 로고    scopus 로고
    • Neuroscience: Glia - more than just brain glue
    • 10.1038/457675a, 19194443
    • Allen NJ, Barres BA. Neuroscience: Glia - more than just brain glue. Nature 2009, 457:675-677. 10.1038/457675a, 19194443.
    • (2009) Nature , vol.457 , pp. 675-677
    • Allen, N.J.1    Barres, B.A.2
  • 14
    • 75849151435 scopus 로고    scopus 로고
    • Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury
    • Lehnardt S. Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury. Glia 2010, 58:253-263.
    • (2010) Glia , vol.58 , pp. 253-263
    • Lehnardt, S.1
  • 15
    • 77950858637 scopus 로고    scopus 로고
    • Microglia in neurodegenerative disease
    • 10.1038/nrneurol.2010.17, 20234358
    • Perry VH, Nicoll JA, Holmes C. Microglia in neurodegenerative disease. Nat Rev Neurol 2010, 6:193-201. 10.1038/nrneurol.2010.17, 20234358.
    • (2010) Nat Rev Neurol , vol.6 , pp. 193-201
    • Perry, V.H.1    Nicoll, J.A.2    Holmes, C.3
  • 16
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • 10.1016/0166-2236(96)10049-7, 8843599
    • Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 1996, 19:312-318. 10.1016/0166-2236(96)10049-7, 8843599.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 17
    • 73049110767 scopus 로고    scopus 로고
    • The multifaceted profile of activated microglia
    • 10.1007/s12035-009-8077-9, 19629762
    • Lynch MA. The multifaceted profile of activated microglia. Mol Neurobiol 2009, 40:139-156. 10.1007/s12035-009-8077-9, 19629762.
    • (2009) Mol Neurobiol , vol.40 , pp. 139-156
    • Lynch, M.A.1
  • 18
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • 10.1002/glia.10161, 12379902
    • Hanisch UK. Microglia as a source and target of cytokines. Glia 2002, 40:140-155. 10.1002/glia.10161, 12379902.
    • (2002) Glia , vol.40 , pp. 140-155
    • Hanisch, U.K.1
  • 19
    • 0034866550 scopus 로고    scopus 로고
    • Microglia: activation and their significance in the central nervous system
    • 10.1093/oxfordjournals.jbchem.a002969, 11481032
    • Nakajima K, Kohsaka S. Microglia: activation and their significance in the central nervous system. J Biochem 2001, 130:169-175. 10.1093/oxfordjournals.jbchem.a002969, 11481032.
    • (2001) J Biochem , vol.130 , pp. 169-175
    • Nakajima, K.1    Kohsaka, S.2
  • 20
    • 36749051047 scopus 로고    scopus 로고
    • Chronic microglial activation and progressive dopaminergic neurotoxicity
    • 10.1042/BST0351127, 17956294
    • Block ML, Hong JS. Chronic microglial activation and progressive dopaminergic neurotoxicity. Biochem Soc Trans 2007, 35:1127-1132. 10.1042/BST0351127, 17956294.
    • (2007) Biochem Soc Trans , vol.35 , pp. 1127-1132
    • Block, M.L.1    Hong, J.S.2
  • 21
    • 33746354022 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
    • 10.1074/jbc.M600504200, 16720574
    • Takeuchi H, Jin S, Wang J, Zhang G, Kawanokuchi J, Kuno R, Sonobe Y, Mizuno T, Suzumura A. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J Biol Chem 2006, 281:21362-21368. 10.1074/jbc.M600504200, 16720574.
    • (2006) J Biol Chem , vol.281 , pp. 21362-21368
    • Takeuchi, H.1    Jin, S.2    Wang, J.3    Zhang, G.4    Kawanokuchi, J.5    Kuno, R.6    Sonobe, Y.7    Mizuno, T.8    Suzumura, A.9
  • 22
    • 43049125769 scopus 로고    scopus 로고
    • Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors
    • 10.1016/j.lfs.2008.03.010, 18452953
    • Yawata I, Takeuchi H, Doi Y, Liang J, Mizuno T, Suzumura A. Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors. Life Sci 2008, 82:1111-1116. 10.1016/j.lfs.2008.03.010, 18452953.
    • (2008) Life Sci , vol.82 , pp. 1111-1116
    • Yawata, I.1    Takeuchi, H.2    Doi, Y.3    Liang, J.4    Mizuno, T.5    Suzumura, A.6
  • 23
    • 80053566487 scopus 로고    scopus 로고
    • Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia
    • 10.1002/glia.21235, 22253048
    • Higashi Y, Segawa S, Matsuo T, Nakamura S, Kikkawa Y, Nishida K, Nagasawa K. Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia. Glia 2011, 59:1933-1945. 10.1002/glia.21235, 22253048.
    • (2011) Glia , vol.59 , pp. 1933-1945
    • Higashi, Y.1    Segawa, S.2    Matsuo, T.3    Nakamura, S.4    Kikkawa, Y.5    Nishida, K.6    Nagasawa, K.7
  • 24
    • 38049188027 scopus 로고    scopus 로고
    • ATP released from beta-amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion
    • 10.1038/emm.2007.89, 18160853
    • Kim SY, Moon JH, Lee HG, Kim SU, Lee YB. ATP released from beta-amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion. Exp Mol Med 2007, 39:820-827. 10.1038/emm.2007.89, 18160853.
    • (2007) Exp Mol Med , vol.39 , pp. 820-827
    • Kim, S.Y.1    Moon, J.H.2    Lee, H.G.3    Kim, S.U.4    Lee, Y.B.5
  • 25
    • 61849111196 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis
    • 2952353, 19368827
    • Carmen J, Rothstein JD, Kerr DA. Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis. Brain Res 2009, 1263:143-154. 2952353, 19368827.
    • (2009) Brain Res , vol.1263 , pp. 143-154
    • Carmen, J.1    Rothstein, J.D.2    Kerr, D.A.3
  • 26
    • 42549107361 scopus 로고    scopus 로고
    • The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis
    • 10.1111/j.1471-4159.2008.05230.x, 2579753, 18194440
    • Prow NA, Irani DN. The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis. J Neurochem 2008, 105:1276-1286. 10.1111/j.1471-4159.2008.05230.x, 2579753, 18194440.
    • (2008) J Neurochem , vol.105 , pp. 1276-1286
    • Prow, N.A.1    Irani, D.N.2
  • 27
    • 0027944554 scopus 로고
    • Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms
    • Volterra A, Trotti D, Racagni G. Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms. Mol Pharmacol 1994, 46:986-992.
    • (1994) Mol Pharmacol , vol.46 , pp. 986-992
    • Volterra, A.1    Trotti, D.2    Racagni, G.3
  • 28
    • 77749243037 scopus 로고    scopus 로고
    • Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling
    • 10.1111/j.1471-4159.2010.06589.x, 20070863
    • Liu YP, Yang CS, Chen MC, Sun SH, Tzeng SF. Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling. J Neurochem 2010, 113:213-227. 10.1111/j.1471-4159.2010.06589.x, 20070863.
    • (2010) J Neurochem , vol.113 , pp. 213-227
    • Liu, Y.P.1    Yang, C.S.2    Chen, M.C.3    Sun, S.H.4    Tzeng, S.F.5
  • 29
    • 0141543841 scopus 로고    scopus 로고
    • Estrogens inhibit l-glutamate uptake activity of astrocytes via membrane estrogen receptor alpha
    • 10.1046/j.1471-4159.2003.01953.x, 12950458
    • Sato K, Matsuki N, Ohno Y, Nakazawa K. Estrogens inhibit l-glutamate uptake activity of astrocytes via membrane estrogen receptor alpha. J Neurochem 2003, 86:1498-1505. 10.1046/j.1471-4159.2003.01953.x, 12950458.
    • (2003) J Neurochem , vol.86 , pp. 1498-1505
    • Sato, K.1    Matsuki, N.2    Ohno, Y.3    Nakazawa, K.4
  • 30
    • 46449106282 scopus 로고    scopus 로고
    • Effects of tamoxifen on L-glutamate transporters of astrocytes
    • 10.1254/jphs.08039SC, 18544895
    • Sato K, Saito Y, Oka J, Ohwada T, Nakazawa K. Effects of tamoxifen on L-glutamate transporters of astrocytes. J Pharmacol Sci 2008, 107:226-230. 10.1254/jphs.08039SC, 18544895.
    • (2008) J Pharmacol Sci , vol.107 , pp. 226-230
    • Sato, K.1    Saito, Y.2    Oka, J.3    Ohwada, T.4    Nakazawa, K.5
  • 31
    • 0026521995 scopus 로고
    • Identification of elastase as a secretory protease from cultured rat microglia
    • 10.1111/j.1471-4159.1992.tb11356.x, 1548474
    • Nakajima K, Shimojo M, Hamanoue M, Ishiura S, Sugita H, Kohsaka S. Identification of elastase as a secretory protease from cultured rat microglia. J Neurochem 1992, 58:1401-1408. 10.1111/j.1471-4159.1992.tb11356.x, 1548474.
    • (1992) J Neurochem , vol.58 , pp. 1401-1408
    • Nakajima, K.1    Shimojo, M.2    Hamanoue, M.3    Ishiura, S.4    Sugita, H.5    Kohsaka, S.6
  • 32
    • 0345700737 scopus 로고    scopus 로고
    • The bisphosphonate clodronate depletes microglial cells in excitotoxically injured organotypic hippocampal slice cultures
    • 10.1016/S0014-4886(02)00049-3, 12710928
    • Kohl A, Dehghani F, Korf HW, Hailer NP. The bisphosphonate clodronate depletes microglial cells in excitotoxically injured organotypic hippocampal slice cultures. Exp Neurol 2003, 181:1-11. 10.1016/S0014-4886(02)00049-3, 12710928.
    • (2003) Exp Neurol , vol.181 , pp. 1-11
    • Kohl, A.1    Dehghani, F.2    Korf, H.W.3    Hailer, N.P.4
  • 33
    • 0034504243 scopus 로고    scopus 로고
    • Measurement of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction activity and lactate dehydrogenase release using MTT
    • 10.1016/S0168-0102(00)00188-7, 11164558
    • Abe K, Matsuki N. Measurement of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction activity and lactate dehydrogenase release using MTT. Neurosci Res 2000, 38:325-329. 10.1016/S0168-0102(00)00188-7, 11164558.
    • (2000) Neurosci Res , vol.38 , pp. 325-329
    • Abe, K.1    Matsuki, N.2
  • 34
    • 32844457508 scopus 로고    scopus 로고
    • Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes
    • 10.1016/j.neuroscience.2005.11.039, 16414200
    • Wink MR, Braganhol E, Tamajusuku AS, Lenz G, Zerbini LF, Libermann TA, Sévigny J, Battastini AM, Robson SC. Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes. Neuroscience 2006, 138:421-432. 10.1016/j.neuroscience.2005.11.039, 16414200.
    • (2006) Neuroscience , vol.138 , pp. 421-432
    • Wink, M.R.1    Braganhol, E.2    Tamajusuku, A.S.3    Lenz, G.4    Zerbini, L.F.5    Libermann, T.A.6    Sévigny, J.7    Battastini, A.M.8    Robson, S.C.9
  • 35
    • 45549099573 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present
    • 10.1523/JNEUROSCI.3995-07.2008, 2677805, 18480288
    • Li J, Ramenaden ER, Peng J, Koito H, Volpe JJ, Rosenberg PA. Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present. J Neurosci 2008, 28:5321-5330. 10.1523/JNEUROSCI.3995-07.2008, 2677805, 18480288.
    • (2008) J Neurosci , vol.28 , pp. 5321-5330
    • Li, J.1    Ramenaden, E.R.2    Peng, J.3    Koito, H.4    Volpe, J.J.5    Rosenberg, P.A.6
  • 36
    • 0035449358 scopus 로고    scopus 로고
    • Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity
    • Bal-Price A, Brown GC. Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J Neurosci 2001, 21:6480-6491.
    • (2001) J Neurosci , vol.21 , pp. 6480-6491
    • Bal-Price, A.1    Brown, G.C.2
  • 38
    • 13544272944 scopus 로고    scopus 로고
    • Differential activation of astrocytes by innate and adaptive immune stimuli
    • 10.1002/glia.20117, 15538753
    • Carpentier PA, Begolka WS, Olson JK, Elhofy A, Karpus WJ, Miller SD. Differential activation of astrocytes by innate and adaptive immune stimuli. Glia 2005, 49:360-374. 10.1002/glia.20117, 15538753.
    • (2005) Glia , vol.49 , pp. 360-374
    • Carpentier, P.A.1    Begolka, W.S.2    Olson, J.K.3    Elhofy, A.4    Karpus, W.J.5    Miller, S.D.6
  • 39
    • 34547435817 scopus 로고    scopus 로고
    • Neuroinflammation and regulation of glial glutamate uptake in neurological disorders
    • 10.1002/jnr.21325, 17497670
    • Tilleux S, Hermans E. Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J Neurosci Res 2007, 85:2059-2070. 10.1002/jnr.21325, 17497670.
    • (2007) J Neurosci Res , vol.85 , pp. 2059-2070
    • Tilleux, S.1    Hermans, E.2
  • 40
    • 0031020015 scopus 로고    scopus 로고
    • Longuemare MC: Neuronal regulation of glutamate transporter subtype expression in astrocytes
    • Swanson RA, Liu J, Miller JW, Rothstein JD, Farrell K, Stein BA. Longuemare MC: Neuronal regulation of glutamate transporter subtype expression in astrocytes. J Neurosci 1997, 17:932-940.
    • (1997) J Neurosci , vol.17 , pp. 932-940
    • Swanson, R.A.1    Liu, J.2    Miller, J.W.3    Rothstein, J.D.4    Farrell, K.5    Stein, B.A.6
  • 41
    • 0033840578 scopus 로고    scopus 로고
    • The GLT1 and GLAST glutamate transporters are expressed on morphologically distinct astrocytes and regulated by neuronal activity in primary hippocampal cocultures
    • Perego C, Vanoni C, Bossi M, Massari S, Basudev H, Longhi R, Pietrini G. The GLT1 and GLAST glutamate transporters are expressed on morphologically distinct astrocytes and regulated by neuronal activity in primary hippocampal cocultures. J Neurochem 2000, 75:1076-1084.
    • (2000) J Neurochem , vol.75 , pp. 1076-1084
    • Perego, C.1    Vanoni, C.2    Bossi, M.3    Massari, S.4    Basudev, H.5    Longhi, R.6    Pietrini, G.7
  • 42
    • 0034257164 scopus 로고    scopus 로고
    • The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms
    • 10.1016/S0197-0186(00)00019-X, 10812201
    • Gegelashvili G, Dehnes Y, Danbolt NC, Schousboe A. The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms. Neurochem Int 2000, 37:163-170. 10.1016/S0197-0186(00)00019-X, 10812201.
    • (2000) Neurochem Int , vol.37 , pp. 163-170
    • Gegelashvili, G.1    Dehnes, Y.2    Danbolt, N.C.3    Schousboe, A.4
  • 43
    • 0038810014 scopus 로고    scopus 로고
    • Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins
    • 10.1046/j.1460-9568.2003.02657.x, 12786977
    • Aronica E, Gorter JA, Ijlst-Keizers H, Rozemuller AJ, Yankaya B, Leenstra S, Troost D. Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins. Eur J Neurosci 2003, 17:2106-2118. 10.1046/j.1460-9568.2003.02657.x, 12786977.
    • (2003) Eur J Neurosci , vol.17 , pp. 2106-2118
    • Aronica, E.1    Gorter, J.A.2    Ijlst-Keizers, H.3    Rozemuller, A.J.4    Yankaya, B.5    Leenstra, S.6    Troost, D.7
  • 44
    • 33746632965 scopus 로고    scopus 로고
    • Glutamate-dependent translational regulation in cultured Bergmann glia cells: involvement of p70S6K
    • 10.1016/j.neuroscience.2006.04.076, 16766130
    • González-Mejia ME, Morales M, Hernández-Kelly LC, Zepeda RC, Bernabé A, Ortega A. Glutamate-dependent translational regulation in cultured Bergmann glia cells: involvement of p70S6K. Neuroscience 2006, 141:1389-1398. 10.1016/j.neuroscience.2006.04.076, 16766130.
    • (2006) Neuroscience , vol.141 , pp. 1389-1398
    • González-Mejia, M.E.1    Morales, M.2    Hernández-Kelly, L.C.3    Zepeda, R.C.4    Bernabé, A.5    Ortega, A.6
  • 46
    • 0028832649 scopus 로고
    • Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes
    • 10.1073/pnas.92.21.9450, 40819, 7568152
    • Stanbrough M, Rowen DW, Magasanik B. Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes. Proc Natl Acad Sci USA 1995, 92:9450-9454. 10.1073/pnas.92.21.9450, 40819, 7568152.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9450-9454
    • Stanbrough, M.1    Rowen, D.W.2    Magasanik, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.