Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection

Neuroscience Letters

Volumn 505, Issue 2, 2011, Pages 140-145

  Piers, Thomas M ^a   Heales, Simon J ^b   Pocock, Jennifer M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Fibrinogen; MGluR5; Microglia; Neurotoxicity

Indexed keywords

FIBRINOGEN; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 5;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL ACTIVATION; CELL INFILTRATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NEUROMODULATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION;

ALLOSTERIC REGULATION; ANIMALS; ANIMALS, NEWBORN; BLOOD-BRAIN BARRIER; COCULTURE TECHNIQUES; DOWN-REGULATION; FIBRINOGEN; GLIOSIS; INFLAMMATION MEDIATORS; MICROGLIA; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 81055157599     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.10.007     Document Type: Article

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