Brain plasticity-based therapeutics

Frontiers in Human Neuroscience

Volumn 8, Issue JUNE, 2014, Pages

  Merzenich, Michael M ^a   Van Vleet, Thomas M ^a,b   Nahum, Mor ^a,c  

^a Posit Science Corporation   (United States)

^b Medical Research Department of Veteran Affairs   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Brain plasticity; Computerized training; Hemispatial neglect; Neuroplasticity; Schizophrenia

Indexed keywords

ACETYLCHOLINE; DOPAMINE; NEUROLEPTIC AGENT; NEUROTRANSMITTER; NORADRENALIN;

AGING; ALZHEIMER DISEASE; ASSOCIATIVE MEMORY; BEHAVIOR CHANGE; BEHAVIOR THERAPY; BRAIN CELL; COGNITIVE DEFECT; COGNITIVE THERAPY; COMPUTER ASSISTED THERAPY; CONNECTOME; COORDINATION; DEGENERATIVE DISEASE; FEEDBACK SYSTEM; HEALTH CARE DELIVERY; HEMISPATIAL NEGLECT SYNDROME; HUMAN; HUMAN COMPUTER INTERACTION; LIMBIC SYSTEM; MOOD DISORDER; NERVE CELL PLASTICITY; NEUROLOGIC DISEASE; NEUROMODULATION; NEUROSCIENCE; PATIENT COMPLIANCE; REHABILITATION CARE; REVIEW; SCHIZOPHRENIA; SELECTIVE ATTENTION; SELF CONCEPT; SUBSTANCE ABUSE; SYMPTOMATOLOGY; SYNAPSE; SYNAPTOGENESIS; WORKING MEMORY;

EID: 84903476983     PISSN: None     EISSN: 16625161     Source Type: Journal    
DOI: 10.3389/fnhum.2014.00385     Document Type: Review

References (160)

1. Adcock, R. A., Dale, C., Fisher, M., Aldebot, S., Genevsky, A., Simpson, G. V., et al. (2009). When top-down meets bottom-up: auditory training enhances verbal memory in schizophrenia. Schizophr. Bull. 35, 1132-1141. doi: 10.1093/schbul/sbp068
2. Ahissar, E., Vaadia, E., Ahissar, M., Bergman, H., Arieli, A., and Abeles, M. (1992). Dependence of cortical plasticity on correlated activity of single neurons and on behavioral context. Science 257, 1412-1415. doi: 10.1126/science. 1529342
3. Ahissar, M., Nahum, M., Nelken, I., and Hockstein, S. (2009). Reverse hierarchies and sensory learning. Philos. Trans. R. Soc. Lond. B Biol. Sci. 364, 285-299. doi: 10.1098/rstb.2008.0253
4. Aston-Jones, G., and Cohen, J. D. (2005). An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu. Rev. Neurosci. 28, 403-450. doi: 10.1146/annurev.neuro.28.061604. 135709
5. Aston-Jones, J., Rajkowski, J., and Cohen, J. (1999). Role of locus coeruleus in attention and behavioral flexibility. Biol. Psychiatry 46, 1309-1320. doi: 10.1016/S0006-3223(99)00140-7
6. Backman, L., Lindenberger, U., Li, S. C., and Nyberg, L. (2010). Linking cognitive aging to alterations in dopamine neurotransmitter functioning: recent data and future avenues. Neurosci. Biobehav. Rev. 34, 670-677. doi: 10.1016/j.neurobiorev.2009.12.008
7. Ball, K., Edwards, J. D., and Ross, L. A. (2007). The impact of speed of processing training on cognitive and everyday functions. J. Gerontol. B Psychol. Sci. Soc. Sci. 62, 19-31. doi: 10.1093/geronb/62.special_issue_1.19
8. Ball, K., Edwards, J. D., Ross, L. A., and McGwin, G. Jr. (2010). Cognitive training decreases motor vehicle collision involvement of older draivers. J. Am. Geriatr. Soc. 58, 2107-2113. doi: 10.1111/j.1532-5415.2010.03138.x
9. Bao, S., Chan, V. T., and Merzenich, M. M. (2001). Cortical remodeling induced by activity of ventral tegmentFal dopamine neurons. Nature 412, 79-83. doi: 10.1038/35083586
10. Bao, S., Chan, V. T., Zhang, L. I., and Merzenich, M. M. (2003). Suppression of cortical representation through backward conditioning. Proc. Natl. Acad. Sci. U.S.A. 100, 1405-1408. doi: 10.1073/pnas.0337527100
11. Barili, P., De Carolis, G., Zacheo, D., and Amenta, F. (1998). Sensitivity to aging of the limbic dopaminergic system: a review. Mech. Aging Dev. 106, 57-92. doi: 10.1016/S0047-6374(98)00104-3
12. Barrett, A. M., Goedert, K. M., and Basso, J. C. (2012). Prism adaptation for spatial neglect after stroke: translational practice gaps. Nat. Rev. Neurol. 8, 567-577. doi: 10.1038/nrneurol.2012.170
13. Becker, H. E., Nieman, D. H., Wiltink, S., Dingemans, P. M., van de Fliert, J. R., Velthorst, E., et al. (2010). Neurocognitive functioning before and after the first psychotic episode: does psychosis result in cognitive deterioration? Psychol. Med. 40, 1599-1606. doi: 10.1017/S0033291710000048
14. Bell, M., Tsang, H. W., Greig, T. C., and Bryson, G. J. (2009). Neurocognition, social cognition, perceived social discomfort, and vocational outcomes in schizophrenia. Schizophr. Bull. 35, 738-747. doi: 10.1093/schbul/ sbm169
15. Berry, A. S., Zanto, T. P., Clapp, W. C., Hardy, J. L., Delahunt, P. B., Mahncke, H. W., et al. (2010). The influence of perceptual training on working memory in older adults. PLoS ONE 5:e11537. doi: 10.1371/journal.pone. 0011537
16. Biagianti, B., and Vinogradov, S. (2013). Computerized cognitive training targeting brain plasticity in schizophrenia. Prog. Brain Res. 207, 301-326. doi: 10.1016/B978-0-444-63327-9.00011-4
17. Billeke, P., and Aboitiz, F. (2013). Social cognition in schizophrenia: from social stimuli processing to social engagement. Front. Psychiatry 4:4. doi: 10.3389/fpsyt.2013.00004
18. Boring, E. (1929). A History of Experimental Psychology. New York, NY: Century.
19. Bouret, S., and Sara, S. J. (2005). Network reset: a simplified overarching theory of locus coeruleus noradrenaline function. Trends Neurosci. 28, 574-582. doi: 10.1016/j.tins.2005.09.002
20. Brewer, W. J., Francey, S. M., Wood, S. J., Jackson, H. J., Pantelis, C., Phillips, L. J., et al. (2005). Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis. Am. J. Psychiatry 162, 71-78. doi: 10.1176/appi.ajp.162.1.71
21. Buxhoeveden, D. P., and Casanova, M. F. (2002). "The minicolumn hypothesis in neuroscience." Brain 125, 935-951. doi: 10.1093/brain/awf110
22. Calciano, M., Lemarie, J. C., Blondiaux, E., Einstein, R., and Fehlbaum-Beurdeley, P. (2013). A predictive microarray-based biomarker for early detection of Alzheimer's disease intended for clinical diagnostic application. Biomarkers 13, 264-272. doi: 10.3109/1354750X.2013.773083
23. Carcea, I., and Froemke, R. C. (2013). Cortical plasticity, excitatory-inhibitory balance, and sensory perception. Prog. Brain Res. 207, 65-90. doi: 10.1016/B978-0-444-63327-9.00003-5
24. Chan, R. C., Li, H., Cheung, E. F., and Gong, Q. Y. (2010). Impaired facial emotion perception in schizophrenia: a meta-analysis. Psychiatry Res. 178, 381-390. doi: 10.1016/j.psychres.2009.03.035
25. Cirillo, M. A., and Seidman, L. J. (2003). Verbal declarative memory dysfunction in schizophrenia: from clinical assessment to genetics and brain mechanisms. Neuropsychol. Rev. 13, 43-77. doi: 10.1023/A:1023870821631
26. Compte, A. (2006). Computational and in vitro studies of persistent activity: edging towards cellular and synaptic mechanisms of working memory. Neuroscience 139, 135-151. doi: 10.1016/j.neuroscience.2005.06.011
27. Cooper, L. N., and Bear, M. F. (2012). The BCM theory of synapse modification at 30: interaction of theory with experiment. Nat. Rev. Neurosci. 13, 798-810. doi: 10.1038/nrn3353
28. Corbetta, M., and Shulman, G. L. (2011). Spatial neglect and attention networks. Annu. Rev. Neurosci. 34, 569-599. doi: 10.1146/annurev-neuro-061010-113731
29. Couture, S. M., Penn, D. L., and Roberts, D. L. (2006). The functional significance of social cognition in schizophrenia: a review. Schizophr. Bull. 32, S44-S63. doi: 10.1093/schbul/sbl029
30. Dale, C. L., Findlay, A. M., Adcock, R. A., Vertinski, M., Fisher, M., Genevsky, A., et al. (2010). Timing is everything: neural response dynamics during syllable processing and its relation to higher-order cognition in schizophrenia and healthy comparison subjects. Int. J. Psychophysiol. 75, 183-193. doi: 10.1016/j. ijpsycho.2009.10.009
31. Dan, Y., and Poo, M. M. (2006). Spike timing-dependent plasticity: from synapse to perception. Physiol. Rev. 86, 1033-1048. doi: 10.1152/physrev. 00030.2005
32. DeGutis, J., and Van Vleet, T. M. (2010). Tonic and phasic alertness training: a novel behavioral therapy to improve spatial and non-spatial attention in patients with hemispatial neglect. Front. Hum. Neurosci. 4:60. doi: 10.3389/fnhum.2010.00060
33. de Villers-Sidani, E., Alzghoul, L., Zhou, X., Simpson, K. L., Lin, R. C., and Merzenich, M. M. (2010). Recovery of functional and structural age-related changes in the rat primary auditory cortex with operant training. Proc. Natl. Acad. Sci. U.S.A. 107, 13900-13905. doi: 10.1073/pnas.1007 885107
34. de Villers-Sidani, E., and Merzenich, M. M. (2011). Lifelong plasticity in the rat auditory cortex: basic mechanisms and role of sensory experience. Prog. Brain Res. 191, 119-131. doi: 10.1016/B978-0-444-53752-2.00009-6
35. Duncan, J., Bundesen, C., Olson, A., Humphreys, G., Chavda, S., and Shibuya, H. (1999). Systematic analysis of deficits in visual attention. J. Exp. Psychol. Gen. 128, 450-478. doi: 10.1037/0096-3445.128.4.450
36. Eastvold, A. D., Heaton, R. K., and Cadenhead, K. S. (2007). Neurocognitive deficits in the (putative) prodrome and first episode of psychosis. Schizophr. Res. 93, 266-277. doi: 10.1016/j.schres.2007.03.013
37. Edelman, G. (1987). Neural Darwinism: The Theory of Neuronal Group Selection. New York, NY: Basic Books.
38. Edwards, J., Pattison, P. E., Jackson, H. J., and Wales, R. J. (2001). Facial affect and affective prosody recognition in first-episode schizophrenia. Schizophr Res. 48, 235-253. doi: 10.1016/S0920-9964(00)00099-2
39. Edwards, J. D., Myers, C., Ross, L. A., Roenker, D. L., Cissell, G. M., McLaughlin, A. M., et al. (2009). The longitudinal impact of cognitive speed of processing training on driving mobility. Gerontologist 49, 485-494. doi: 10.1093/geront/ gnp042
40. Fass, D. M., Schroeder, F. A., Perlis, R. H., and Haggarty, S. J. (2014). Epigenetic mechanisms in mood disorders: targeting neuroplasticity. Neuroscience 264, 112-130. doi: 10.1016/j.neuroscience.2013.01.041
41. Feldman, D. E. (2012). The spike-timing dependence of plasticity. Neuron 75, 55-71. doi: 10.1016/neuron.2012.08.001
42. Fernandez, A. (2011). The business and ethics of the brain fitness boom. Generations 35, 63-69.
43. Fett, A. K., Viechtbauer, W., Dominguez, M. D., Penn, D. L., van, Os. J., and Krabbendam, L. (2011). The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci. Biobehav. Rev. 35, 573-588. doi: 10.1016/j.neubiorev.2010.07.001
44. Fisher, M., Holland, C., Merzenich, M. M., and Vinogradov, S. (2009b). Using neuroplasticity-based auditory training to improve verbal memory in schizophrenia. Am. J. Psychiatry 166, 805-811. doi: 10.1176/appi.ajp.2009. 08050757
45. Fisher, M., Holland, C., Subramaniam, K., and Vinogradov, S. (2009a). Neuroplasticity-based cognitive training in schizophrenia: an interim report on the effects 6 months later. Schizophr. Bull. 36, 869-879. doi: 10.1093/schbul/ sbn170
46. Fisher, M., Loewy, R., Hardy, K., Schlosser, D., and Vinogradov, S. (2013). Cognitive interventions targeting brain plasticity in the prodromal and early phases of schizophrenia. Annu. Rev. Clin. Psychol. 9, 435-463. doi: 10.1146/annurev-clinpsy-032511-143134
47. Fleet, W. S., Valenstein, E., Watson, R. T., and Heilman, K. M. (1987). Dopamine agonist therapy for neglect in humans. Neurology 37, 1765-1765. doi: 10.1212/WNL.37.11.1765
48. Froemke, R. C., Merzenich, M. M., and Schreiner, C. E. (2007). A synaptic memory trace for cortical receptive field plasticity. Nature 450, 425-429. doi: 10.1038/nature06289
49. Fuster, J. (2008). The Prefrontal Cortex, 4th Edn. London: Academic Press.
50. Geminiani, G., Bottini, G., and Sterzi, R. (1998). Dopaminergic stimulation in unilateral neglect. J. Neurol. Neurosurg. Psychiatry 65, 344-347. doi: 10.1136/jnnp.65.3.344
51. Gilbert, C. D., Li, W., and Piech, V. (2009). Perceptual learning and adult cortical plasticity. J. Physiol. 587, 2743-2751. doi: 10.1113/jphysiol.2009.171488
52. Gilman, S. R., Chang, J., Xu, B., Bawa, T. S., Gogos, J. A., Karayiorgou, M., et al. (2012). Diverse types of genetic variation converge on functional gene networks involved in schizophrenia. Nat. Neurosci. 15, 1723-1728. doi: 10.1038/ nn.3261
53. Goff, D. C., Hill, M., and Barch, D. (2011). The treatment of cognitive impairment in schizophrenia. Pharmacol. Biochem. Behav. 99, 245-253. doi: 10.1016/j.pbb.2010.11.009
54. Goldberg, T. E., Goldman, R. S., Burdick, K. E., Malhotra, A. K., Lencz, T., Patel, R. C., et al. (2007). Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect? Arch. Gen. Psychiatry 64, 1115-1122. doi: 10.1001/archpsyc.64.10.1115
55. Goldman-Rakic, P. S. (1995). Cellular basis of working memory. Neuron 14, 477-485. doi: 10.1016/0896-6273(95)90304-6
56. Green, M. F. (2007). Stimulating the development of drug treatments to improve cognition in schizophrenia. Annu. Rev. Clin. Psychol. 3, 159-80. doi: 10.1146/annurev.clinpsy.3.022806.091529
57. Green, M. F., Bearden, C. E., Cannon, T. D., Fiske, A. P., Hellemann, G. S., Horan, W. P., et al. (2012). Social cognition in schizophrenia, Part 1: performance across phase of illness. Schizophr. Bull. 38, 854-864. doi: 10.1093/schbul/sbq171
58. Green, M. F., Kern, R. S., Braff, D. L., and Mintz, J. (2000). Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the "right stuff"? Schizophr. Bull. 26, 119-136. doi: 10.1093/oxfordjournals.schbul. a033430
59. Grossberg, S. (2013). Recurrent neural networks. Scholarpedia 8:1888. doi: 10.4249/scholarpedia.1888
60. Hahn, K., Myers, N., Prigarin, S., Rodenacker, K., Kurz, A., Forstl, H., et al. (2013). Selectively and progressively disrupted structural connectivity of functional brain networks in Alzheimer's Disease revealed by a novel framework to analyze edge distributions of networks detecting disruptions with strong statistical evidence. Neuroimage 81, 96-109. doi: 10.1016/j.neuroimage.2013. 05.011
61. Hebb, D. O. (1949). The Organization of Behavior. New York, NY: J Wiley.
62. Heckers, S. (2001). Neuroimaging studies of the hippocampus in schizophrenia. Hippocampus 11, 520-528. doi: 10.1002/hipo.1068
63. Heilman, K. M., Bowers, D., Valenstein, E., and Watson, R. T. (1993). Disorders of visual attention. Baillieres Clin. Neurol. 2, 389-413.
64. Hinkley, L. B., Vinogradov, S., Guggisberg, A. G., Fisher, M., Findlay, A. M., and Nagarajan, S. S. (2011). Clinical symptoms and alpha band resting-state functional connectivity imaging in patients with schizophrenia: implications for novel approaches to treatment. Biol. Psychiatry 70, 1134-1142. doi: 10.1016/j.biopsych.2011.06.029
65. Hjaltason, H., Tegner, R., Tham, K., Levander, M., and Ericson, K. (1996). Sustained attention and awareness of disability in chronic neglect. Neuropsychologia 34, 1229-1233. doi: 10.1016/0028-3932(96)00044-9
66. Hochstein, S., and Ahissar, M. (2002). View from the top: hierarchies and reverse hierarchies in the visual system. Neuron 36, 791-805. doi: 10.1016/S0896-6273(02)01091-7
67. Hooker, C. I., Bruce, L., Fisher, M., Verosky, S. C., Miyakawa, A., D'Esposito, M., et al. (2013). The influence of combined cognitive plus social-cognitive training on amygdala response during face emotion recognition in schizophrenia. Psychiatry Res. 213, 99-107. doi: 10.1016/j.pscychresns.2013.04.001
68. Hooker, C. I., Bruce, L., Fisher, M., Verosky, S. C., Miyakawa, A., and Vinogradov S. (2012). Neural activity during emotion recognition after combined cognitive plus social cognitive training in schizophrenia. Schizophr. Res. 139, 53-59. doi: 10.1016/j.schres.2012.05.009
69. Horng, S. H., and Sur, M. (2006). Visual activity and cortical rewiring: activity-dependent plasticity of cortical neurons. Prog. Brain Res. 157, 3-11. doi: 10.1016/S0079-6123(06)57001-3
70. Husain, M., and Rorden, C. (2003). Non-spatially lateralized mechanisms in hemispatial neglect. Nat. Rev. Neurosci. 4, 26-36. doi: 10.1038/nrn1005
71. Husain, M., Shapiro, K., Martin, J., and Kennard, C. (1997). Abnormal temporal dynamics of visual attention in spatial neglect patients. Nature 385, 154-156. doi: 10.1038/385154a0
72. Jagust, W. (2013). Vulnerable neural systems and the borderland of brain aging and neurodegeneration. Neuron 77, 219-234. doi: 10.1016/j.neuron.2013.01.002
73. Jardanhazi-Kurutz, D., Kummer, M. P., Terwel, D., Vogel, K., Dyrks, T., Thiele, A., et al. (2010). Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits. Neurochem. Int. 57, 375-382. doi: 10.1016/j.neuint.2010.02.001
74. Jardanhazi-Kurutz, D., Kummer, M. P., Terwel, D., Vogel, K., Thiele, A., and Heneka, M. T. (2011). Distinct adrenergic system changes and neuroinflamma-tion in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice. Neuroscience 176, 396-407. doi: 10.1016/j.neuroscience.2010.11.052
75. Kalinin, S., Polak, P. E., Lin, S. X., Sakharkar, A. J., Pandey, S. C., and Feinstein, D. L. (2012). The noradrenaline precursor L-DOPS reduces pathology in a mouse model of Alzheimer's disease. Neurobiol. Aging 33, 1651-1663. doi: 10.1016/j.neurobiolaging.2011.04.012
76. Kamal, B., Holman, C., and de Villers-Sidani, E. (2013). Shaping the aging brain: role of auditory input patterns in the emergence of auditory cortical impairments. Front. Syst. Neurosci. 7:52. doi: 10.3389/fnsys.2013.00052
77. Keefe, R. S., Bilder, R. M., Davis, S. M., Harvey, P. D., Palmer, B. W., Gold, J. M., et al. (2007). Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial. Arch. Gen. Psychiatry 64, 633-647. doi: 10.1001/archpsyc.64.6.633
78. Keefe, R. S., Perkins, D. O., Gu, H., Zipursky, R. B., Christensen, B. K., and Lieberman, J. A. (2006). A longitudinal study of neurocognitive function in individuals at-risk for psychosis. Schizophr. Res. 88, 26-35. doi: 10.1016/j.schres.2006.06.041
79. Keefe, R. S., Vinogradov, S., Medalia, A., Buckley, P. F., Caroff, S. N., D'Souza, D. C., et al. (2012). Feasibility and pilot efficacy results from the multisite Cognitive Remediation in the Schizophrenia Trials Network (CRSTN) randomized controlled trial. J. Clin. Psychiatry 73, 1016-1022. doi: 10.4088/JCP.11m07100
80. Kim, H. S., Shin, N. Y., Jang, J. H., Kim, E., Shim, G., Park, H. Y., et al. (2011). Social cognition and neurocognition as predictors of conversion to psychosis in individuals at ultra-high risk. Schizophr. Res. 130, 170-175. doi: 10.1016/j.schres.2011.04.023
81. Kleim, J. A., Barbay, S., Cooper, N. R., Hogg, T. M., Reidel, C. N., Remple, M. S., et al. (2002). Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex. Neurobiol. Learn. Mem. 77, 63-77. doi: 10.1006/nlme.2000.4004
82. Klingberg, T. (2010). Training and plasticity of working memory. Trends Cogn. Sci. 14, 317-324. doi: 10.1016/j.ics.2010.05.002
83. Koffie, R. M., Hyman, B. T., and Spires-Jones, T. L. (2011). Alzheimer's disease: synapses gone cold. Mol. Neurodegener. 6:63. doi: 10.1186/1750-1326-6-63
84. Kohler, C. G., Walker, J. B., Martin, E. A., Healey, K. M., and Moberg, P. J. (2010). Facial emotion perception in schizophrenia: a meta-analytic review. Schizophr. Bull. 36, 1009-1019. doi: 10.1093/schbul/sbn192
85. Kong, Y., Ruan, L., Qian, L., Liu, X., and Le, Y. (2010). Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme. J. Neurosci. 30, 11848-11857. doi: 10.1523/JNEUROSCI.2985-10.2010
86. Lencz, T., Smith, C. W., McLaughlin, D., Auther, A., Nakayama, E., Hovey, L., et al. (2006). Generalized and specific neurocognitive deficits in prodromal schizophrenia. Biol. Psychiatry 59, 863-871. doi: 10.1016/j.biopsych.2005.09.005
87. Lisman, J., Grace, A. A., and Duzel, E. (2011). A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP. Trends Neursci. 34, 536-547. doi: 10.1016/j.tins.2011.07.006
88. Lo, R. Y., Hubbard, A. E., Shaw, L. M., Trojanowski, J. Q., Petersen, R. C., Aisen, P. S., et al. (2011). Longitudinal change of biomarkers in cognitive decline. Arch. Neurol. 68, 1257-1266. doi: 10.1001/archneurol.2011.123
89. López-Muñoz, F., and Alamo, C. (2009). Monaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today. Curr. Pharm. Des. 15, 1563-1586. doi: 10.2174/138161209788168001
90. Mahncke, H. W., Bronstone, A., and Merzenich, M. M. (2006). Brain plasticity and functional losses in the aged: scientific bases for a novel intervention. Prog. Brain Res. 157, 81-109. doi: 10.1016/S0079-6123(06)57006-2
91. Marien, M. R., Colpaert, F. C., and Rosenquist, A. C. (2004). Noradrenergic mechanisms in neurodegenerative diseases: a theory. Brain Res. Brain Res. Rev. 45, 38-78. doi: 10.1016/j.brainresrev.2004.02.002
92. McMinn, M. R., Buchanan, T., Ellens, B. M., and Ryan, M. K. (1999). Technology, professional practice, and ethics: survey findings and implications. Prof. Psychol. Res. Pract. 30:165. doi: 10.1037/0735-7028.30.2.165
93. McNamee, E. N., Ryan, K. M., Kilroy, D., and Connor, T. J. (2010). Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity. Eur. J. Pharmacol. 626, 219-228. doi: 10.1016/j.ejphar.2009.09.054
94. Melby-Lervåg, M., and Hulme, C. (2013). Is working memory training effective? A meta-analytic review. Dev. Psychol. 49, 270-291. doi: 10.1037/a0028228
95. Merzenich, M. M. (2001). "Cortical plasticity contributing to child development," in Mechanisms in Cognitive Development, eds J. McClelland and R. Siegler (Mahwah, NJ: Ehrlbaum), 67-96.
96. Merzenich, M. M. (2013). Soft-Wired: How the New Science of Brain Plasticity Can Change Your Life. San Francisco: Parnassus Publishing.
97. Merzenich, M. M., and de Charms, C. (1996). "Neural representations, experience and change," in The Mind-Brain Continuum, eds R. Llinas and P. Churchland (Boston, MA: MIT Press), 61-81.
98. Merzenich, M. M., and Jenkins, W. M. (1993). "Cortical representation of learned behaviors," in Memory Concepts, ed. P. Andersen (Amsterdam, NL: Elsevier), 437-453.
99. Merzenich, M. M., Miller, S., Jenkins, W. M., Saunders, G., Protopapas, A., Peterson, B., et al. (1998). "Amelioration of the acoustic reception and speech reception deficits underlying language-based learning impairments," in Basic Neural Mechanisms in Cognition and Language, ed C.V. Euler (Amsterdam, NL: Elsevier), 143-172.
100. Mesulam, M. (1990). Large-scale neurocognitive networks and distributed processing for attention, language, and memory. Ann. Neurol. 28, 597-613. doi: 10.1002/ana.410280502
101. Minzenberg, M. J., Laird, A. R., Thelen, S., Carter, C. S., and Glahn, D. C. (2009). Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Arch. Gen. Psychiatry 66, 811-822. doi: 10.1001/archgenpsychia-try.2009.91
102. Modinos, G., Costafreda, S. G., van Tol, M. J., McGuire, P. K., Aleman, A., and Allen, P. (2013). Neuroanatomy of and verbal hallucinations in schizopohre-nia: a quantitative meta-analysis of vxel based mprphometry studies. Cortex 49, 1046-1055. doi: 10.1016/cortex.2012.01.009
103. Mufson, E. J., Ma, S. Y., Dills, J., Cochran, E. J., Leurgans, S., Wuu, J., et al. (2002). Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease. J. Comp. Neurol. 443, 136-153. doi: 10.1002/cne.10122
104. Nahum, M., Fisher, M., Loewy, R., Poelke, G., Ventura, J., Nuechterlein, K. H., et al. (2014). A novel, online social cognitive training program for young adults with schizophrenia: a pilot study. Schizophr. Res. Cogn. 1, e11-e19. doi: 10.1016/j.scog.2014.01.003
105. Nahum, M., Garrett, C., Powell, B., Poelke, G., Fisher, M., Mayott, L., et al. (2013a). "Testing the feasibility of a novel computerized neuro-plasticity based training program to remediate social cognition deficits in schizophrenia ('SocialVille')," in Poster Presented at the International Congress on Schizophrenia Research (ICOSR) (Grande Lakes, FL).
106. Nahum, M., Garrett, C., Powell, B., Poelke, G., Fisher, M., Mayott, L., et al. (2013b). "SocialVille: a pilot feasibility study of a neuroplasticity-based computerized training program for social cognition deficits in schizophrenia," in Poster presented at the 2nd Conference of the Entertainment Software and Neurotherapeutics Society (ESCoNS 2) (Los Angeles, CA).
107. Nahum, M., Lee, H., and Merzenich, M. M. (2013c). "Principles of Neuroplasticity-Based Rehabilitation," in Changing Brains-Applying Brain Plasticity to Advance and Recover Human Ability, eds. M.M. Merzenich, M. Nahum, and T. Van Vleet (Amsterdam, NL: Elsevier). Prog Brain Res 207, 141-171. doi: 10.1016/B978-0-444-63327-9.00009-6
108. Nakamura, S., and Sakaguchi, T. (1990). Development and plasticity of the locus coeruleus: a review of recent physiological and pharmaceutical experimentation. Prog. Neurbiol. 34, 505-526. doi: 10.1016/0301-0082(90)90018-C
109. Niendam, T. A., Beatden, C. E., Johnson, J. K., McKinley, M., Loewy, R., O'Brien, M., et al. (2006). Neurocognitive performance and functional disability in the psychosis prodrome. Schizophr. Res. 84, 100-111. doi: 10.1016/j.schres.2006. 02.005
110. Opler, L. A., Medalia, A., Opler, M. G., and Stahl, S. M. (2014). Pharmacotherapy of cognitive deficits in schizophrenia. CNS Spectr. 19, 142-156. doi: 10.1017/S109 2852913000771
111. Peers, P. V., Cusack, R., and Duncan, J. (2006). Modulation of spatial bias in the dual task paradigm: evidence from patients with unilateral parietal lesions and controls. Neuropsychologia 44, 1325-1335. doi: 10.1016/j.neuropsychologia.2006. 01.033
112. Perrine, D. M. (1996). The Chemistry of Mind-Altering Drugs: History, Pharmacology, and Cultural Context. Washington, DC: American Chemical Society.
113. Popov, T., Jordanov, T., Rockstroh, B., Elbert, T., Merzenich, M. M., and Miller, G. A. (2011). Specific cognitive training normalizes auditory sensory gating in schizophrenia: a randomized trial. Biol. Psychiatry 69, 465-471. doi: 10.1016/j.biopsych.2010.09.028
114. Popov, T., Rockstroh, B., Weisz, N., Elbert, T., and Miller, G. A. (2012). Adjusting brain dynamics in schizophrenia by means of perceptual and cognitive training. PLoS ONE 7:e39051. doi: 10.1371/journal.pone.0039051
115. Rapport, M. D., Orban, S. A., Kofler, M. J., and Friedman, L. M. (2013). Do programs designed to train working memory, other executive functions, and attention benefit children with ADHD? A meta-analytic review of cognitive, academic, and behavioral outcomes. Clin. Psychol. Rev. 33, 1237-1252. doi: 10.1016/j.cpr.2013.08.005
116. Reisman, J. M. (1991). A History of Clinical Psychology, 2nd Edn. New York, NY: Taylor and Francis.
117. Reitz, C., Brayne, C., and Mayeux, R. (2011). Epidemiology of Alzheimer disease. Nat. Rev. Neurol. 7, 137-152. doi: 10.1038/nrneurol.2011.2
118. Richardson, R. T., and DeLong, M. R. (1990). Context-dependent responses of primate nucleus basalis neurons in a go/no-go task. J. Neurosci. 10, 2528-2540.
119. Robertson, I. H., Manly, T., Beschin, N., Daini, R., Haeske-Dewick, H., Hömberg, V., et al. (1997). Auditory sustained attention is a marker of unilateral spatial neglect. Neuropsychologia 35, 1527-1532. doi: 10.1016/S0028-3932(97)00084-5
120. Ryan, M., Martin, R., Denckla, M. B., Mostofsky, S. H., and Mahone, E. (2010). Interstimulus jitter facilitates response control in children with ADHD. J. Int. Neuropsychol. Soc. 16, 388-393. doi: 10.1017/S1355617709991305
121. Sacks, S., Fisher, M., Garrett, C., Alexander, P., Holland, C., Rose, D., et al. (2013). Combining computerized social cognitive training with neuroplasticity-based auditory training in schizophrenia. Clin. Schizophr. Relat. Psychoses 7, 78A-86A. doi: 10.3371/CSRP.SAFI.012513
122. Salthouse, T. (2012). Consequencs of age-related cognitive declines. Annu. Rev. Psychol. 63:201-206. doi: 10.1146/annurev-psych-120710-100328
123. Salthouse, T. A. (2000). Aging and measures of processing speed. Biol. Psychol. 54, 35-54. doi: 10.1016/S0301-0511(00)00052-1
124. Sara, S. J. (2009). The locus coeruleus and noradrenergic modulation of cognition. Nat. Rev. Neurosci. 10, 211-223. doi: 10.1038/nrn2573
125. Sara, S. J., and Bouret, S. (2012). Orienting and reorienting: the locus coeruleus mediates cognition through arousal. Neuron 76, 130-141. doi: 10.1016/j.neuron.2012.09.011
126. Sara, S. J., and Segal, M. (1991). Plasticity of sensory responses of locus coeruleus neurons in the behaving rat. Implications for cognition. Prog. Brain Res. 88, 561-585. doi: 10.1016/S0079-6123(08)63835-2
127. Sarter, M., Gehring, W. J., and Kozak, R. (2006). More attention must be paid: the neurobiology of attentional effort. Brain Res. Rev. 51, 145-160. doi: 10.1016/j.brainresrev.2005.11.002
128. Sarter, M., Givens, B., and Bruno, J. P. (2001). The cognitive neuroscience of sustained attention: where top-down meets bottom-up. Brain Res. Brain Res. Rev. 35, 146-160. doi: 10.1016/S0165-017(01)00044-3
129. Schultz, W. (2007). Multiple dopamine functions at different time courses. Annu. Rev. Neurosci. 30, 259-288. doi: 10.1146/annurev.neuro.28.061604.135722
130. Seidman, L. J., Giuliano, A. J., Smith, C. W., Stone, W. S., Glatt, S. J., Meyer, E., et al. (2006). Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside adolescent high risk studies. Schizophr. Bull. 32, 507-524. doi: 10.1093/schbul/sbj078
131. Simon, A. E., Cattapan-Ludewig, K., Zmilacher, S., Arbach, D., Gruber, K., Dvorsky, D. N., et al. (2007). Cognitive functioning in the schizophrenia prodrome. Schizophr. Bull. 33, 761-771. doi: 10.1093/schbul/sbm018
132. Smith, B. A., Goldberg, N. R., and Meshul, C. K. (2011). Effects of treatmill exercise on behavioral recovery and changes in the substantia nigra and striatum of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse. Brain Res. 1386, 60-80. doi: 10.1016/j.brainres.2011.02.003
133. Smith, G. E., Housen, P., Yaffe, K., Ruff, R., Kennison, R. F., Mahncke, H. W., et al. (2009). A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study. J. Am. Geriatr. Soc. 57, 594-603. doi: 10.1111/j.1532-5415.2008.02167.x
134. Steiner, B., Winter, C., Hosman, K., Siebert, E., Kemperman, G., Petrus, D. S., et al. (2006). Enriched environment induces cellular plasaticity in the adult substantia nigra and improves motor function in the 6-OHDA rat model of Parkinson's Disease. Exp. Neurol. 199, 291-300. doi: 10.1016/j.expneurol.2005. 11.004
135. Strenziok, M., Parasuraman, R., Clarke, E., Cisler, D. S., Thompson, J. C., and Greenwood, P. M. (2014). Neurocognitive enhancement in older adults: comparison of three cognitive training tasks to test a hypothesis of training transfer in brain connectivity. Neuroimage 85, 1027-1039. doi: 10.1016/j.neuroimage. 2013.07.069
136. Sturm, W., de Simone, A., Krause, B. J., Specht, K., Hesselmann, V., Radermacher, I., et al. (1999). Functional anatomy of intrinsic alertness: evidence for a fronto-parietal-thalamic-brainstem network in the right hemisphere. Neuropsychologia. 37, 797-805. doi: 10.1006/S0028-3932(98) 00141-9
137. Sturm, W., and Willmes, K. (2001). On the functional neuroanatomy of intrinsic and phasic alertness. Neuroimage 14(1 pt 2), S76-S84. doi: 10.1006/nimg.2001. 0839
138. Subramaniam, K., Luks, T. L., Fisher, M., Simpson, G. V., Nagarajan, S., and Vinogradov, S. (2012). Computerized cognitive training restores neural activity within the reality monitoring network in schizophrenia. Neuron 73, 842-853. doi: 10.1016/j.neuron.2011.12.024
139. Swain, R. A., and Thompson, R. F. (1993). In search of engrams. Ann. N.Y. Acad. Sci. 702, 27-39. doi: 10.1111/j.1749-6632.1993.tb17240.x
140. Thiel, C. M., Zilles, K., and Fink, G. R. (2004). Cerebral correlates of alerting, orienting and reorienting of visuospatial attention: an event-related fMRI study. Neuroimage 21, 318-328. doi: 10.1016/j.neuroimage.2003.08.044
141. Tost, H., Alam, T., and Meyer-Lindenberg, A. (2010). Dopamine and psychosis: theory, pathomechanisms and intermediate phenotypes. Neurosci. Biobehav. Rev. 34, 689-700. doi: 10.1016/jneurobiorev2009.06.005
142. Van Vleet, T. M., and DeGutis, J. M. (2013). Cross-training in hemispatial neglect: auditory sustained attention training ameliorates visual attention deficits. Cortex 49, 679-690. doi: 10.1016/j.cortex.2012.03.020
143. Van Vleet, T. M., and Degutis, J. M. (2014). The nonspatial side of spatial neglect and related approaches to treatment. Prog. Brain Res. 207, 327-349. doi: 10.1016/B978-0-444-63327-9.00012-6
144. Vinogradov, S., Fisher, M., Holland, C., Shelly, W., Wolkowitz, O., and Mellon, S. H. (2009). Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia? Biol. Psychiatry 66, 549-553. doi: 10.1016/j.biopsych.2009.02.017
145. Wang, X. J., Tegner, J., Constantinidis, C., and Goldman-Rakic, P. S. (2004). Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory. Proc. Natl. Acad. Sci. U.S.A. 101, 1368-1378. doi: 10.1073/pnas.0305337101
146. Weinberg, J., Diller, L., Gordon, W. A., Gerstman, L. J., Lieberman, A., Lakin, P., et al. (1977). Visual scanning training effect on reading-related tasks in acquired right brain damage. Arch. Phys. Med. Rehabil. 58, 479-486.
147. Weinberger, N. M. (2004). Specific long-term memory traces in primary auditory cortex. Nat. Rev. Neurosci. 5, 279-290. doi: 10.1038/nrn1366
148. Weinberger, N. M. (2007). Associative representational plasticity in the auditory cortex: a synthesis of two disciplines. Learn. Mem. 14, 1-16. doi: 10.1101/lm. 421807
149. Winder, D. G., Egli, R. E., Schramm, N. L., and Matthews, R. T. (2002). Synaptic plasticity in drug reward circuitry. Curr. Mol. Med. 2, 667-676. doi: 10.2174/1566524023361961
150. Wodka, E. L., Simmonds, D. J., Mahone, E. M., and Mostofsky, S. H. (2009). Moderate variability in stimulus presentation improves motor response control. J. Clin. Exp. Neuropsychol. 31, 483-488. doi: 10.1080/13803390802272036
151. Wolinsky, F. D., Mahncke, H., Vander Weg, M. W., Martin, R., Unverzagt, F. W., Ball, K. K., et al. (2010b). Speed of processing training protects self-rated health in older adults: enduring effects observed in the multi-site ACTIVE randomized controlled trial. Int. Psychogeriatr. 22, 470-478. doi: 10.1017/S1041610209991281
152. Wolinsky, F. D., Mahncke, H. W., Weg, M. W., Martin, R., Unverzagt, F. W., Ball, K. K., et al. (2009). The ACTIVE cognitive training interventions and the onset of and recovery from suspected clinical depression. J. Gerontol. B Psychol. Sci. Soc. Sci. 64, 577-585. doi: 10.1093/geronb/gbp061
153. Wolinsky, F. D., Unverzagt, F. W., Smith, D. M., Jones, R., Stoddard, A., and Tenstedt, S. L. (2006). The ACTIVE cognitive training trial and health-related quality of life: protection that lasts for 5 years. J. Gerontol. A Biol. Sci. Med. Sci. 61:1324. doi: 10.1093/gerona/61.12.1324
154. Wolinsky, F. D., Vander Weg, M. W., Howren, M. B., Jones, M. P., and Dotson, M. M. (2013). A randomized controlled trial of cognitive training using a visual speed of processing intervention in middle aged and older adults. PLoS ONE. 8:e61624. doi: 10.1371/journal.pone.0061624
155. Wolinsky, F. D., Vander Weg, M. W., Martin, R., Unverzagt, F. W., Willis, S. L., Marsiske, M., et al. (2010a). Does cognitive training improve internal locus of control among older adults. J. Gerontol. B Psychol. Sci. Soc. Sci. 65, 591-598. doi: 10.1093/geronb/gbp117
156. Zelinski, E. M., Spina, L. M., Yaffe, K., Ruff, R., Kennison, R. F., Mahncke H.W., et al. (2011). Improvement in memory with plasticity-based adaptive cognitive training: results of the 3-month follow-up. J. Am. Geriatr. Soc. 59, 258-265. doi: 10.1111/j.1532-5415.2010.03277.x
157. Zhang, H., Ozbay, F., Lappalainen, J., Kranzler, H. R., van Dyck, C. H., Charney, D. S., et al. (2006). Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141B, 387-393. doi: 10.1002/ajmg.b.30332
158. Zhou, J., Gennatas, E. D., Kramer, J. H., Miller, B. L., and Seeley, W. W. (2012). Predicting regional neurodegeneration from the healthy brain functional con-nectome. Neuron 73, 1216-1227. doi: 10.1016/j.neuron.2012.03.004
159. Zhou, X., de Villers-Sidani, E., Panizzutti, R., and Merzenich, M. M. (2010). Successive-signal biasing for a learned sound sequence. Proc. Natl. Acad. Sci. U.S.A. 107, 14839-14844. doi: 10.1073/pnas.1009433107
160. Zhou, X., Panizzutti, R., de Villers-Sidani, E., Madeira, C., and Merzenich, M. M. (2011). Natural restoration of critical period plasticity in the juvenile and adult primary auditory cortex. J. Neurosci. 31, 5625-5634. doi: 10.1523/JNEUROSCI.6470-10.2011