Excitotoxicity hypothesis

Neurology

Volumn 47, Issue 4 SUPPL., 1996, Pages

  Rothstein, Jeffrey D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; AMPA RECEPTOR; EXCITATORY AMINO ACID; GABAPENTIN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE RECEPTOR; GLUTAMIC ACID; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RILUZOLE; SUPEROXIDE DISMUTASE; SYNAPTOPHYSIN;

AMINO ACID TRANSPORT; AMYOTROPHIC LATERAL SCLEROSIS; GENE MUTATION; HUMAN; HYPOTHESIS; MOTOR NEURON DISEASE; NERVE CELL DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0029847118     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.47.4_suppl_2.19s     Document Type: Review

References (40)

1. Rowland LP. Ten central themes in a decade of ALS research. In: Rowland LP, ed. Advances in neurology, vol 56. New York: Raven Press, 1991:3-23.
2. Rosen DR, Siddique T, Patterson D, et al. Mutations in Cu/Zn superoxide dismutase are associated with familial amyotrophic lateral sclerosis. Nature 1993;362:59-62.
3. Nicholls DG, Attwell D. (1990). The release and uptake of excitatory amino acids. Trends Pharmacol Sci 1990;11:462-468.
4. Kanner BI, Schuldiner S. Mechanism of transport and storage of neurotransmitters. CRC Crit Rev Biochem 1987;22:1-38.
5. McBean GJ, Roberts PJ. Neurotoxicity of glutamate and DL-threo-hydroxyaspartate in the rat striatum. J Neurochem 1985;44:247-254.
6. Robinson MB, Djali S, Buchhalter JR. Inhibition of glutamate uptake with L-trans-pyrrolidine-2,4-dicarboxylate potentiates glutamate toxicity in primary hippocampal cultures. J Neurochem 1993;61:2099-2103.
7. Rothstein JD, Jin L, Dykes-Hoberg M, Kuncl RW. Chronic glutamate uptake inhibition produces a model of slow neurotoxicity. Proc Natl Acad Sci USA 1993;90:6591-6595.
8. Rothstein JD, Martin LJ, Kuncl RW. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med 1992;22:1464-1468.
9. 1H]D-Aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study. Brain Res 1994;655:195-201.
10. Choi DW, Rothman SM. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci 1990; 13:171-182.
11. Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP, Amara SG. (1994). Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci 1994;14:5559-5569.
12. Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature 1995;375:599-603.
13. Pines G, Danbolt NC, Bjoras M, Zhang Y, Bendahan A, Eide L, Koepsell H, Storm-Mathisen J, Seeberg E, Kanner BI. (1992). Cloning and expression of a rat brain l-glutamate transporter. Nature 1992;360:464-467.
14. Kanai Y, Hediger M. Primary structure and functional characterization of a high affinity glutamate transporter. Nature 1992;360:467-471.
15. +-dependent glutamate/ aspartate transporter from rat brain. Proc Natl Acad Sci USA 1992;89:10955-10959.
16. Rothstein JD, Martin L, Levey AI, Dykes-Hoberg M, Jin L, Wu D, Nash N, Kuncl RW. Localization of neuronal and glial glutamate transporters. Neuron 1994;13:713-725.
17. Rothstein JD, Van Kammen M, Levey AI, Martin L, Kuncl RW. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol 1995;38:73-84.
18. Lehre KP, Levy LM, Ottersen OP, Storm-Mathisen J, Danbolt NC. Differential expression of two glutamate transporters in rat brain: quantitative and immunocytochemical observations. J Neurosci 1995;15:1835-1853.
19. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988;1:623-634.
20. Albin RL, Greenamyre JT. Alternative excitotoxic hypotheses. Neurology 1992;42:733-738.
21. Beal MF, Hyman BT, Koroshétz W. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci 1993;16:125-131.
22. Spink C, Martin DL. Excitatory amino acids in amyotrophic lateral sclerosis [letter]. Ann Neurol 1991;29:110.
23. Shaw PJ, Forrest V, Ince PG, Richardson JP, Wastell HJ. CSF and plasma amino acid levels in motor neuron disease: elevation of CSF glutamate in a subset of patients. Neurodegeneration 1995;4:209-216.
24. Nagy D, Kato T, Kushner PD. Reactive astrocytes are wide-spread in the cortical gray matter of amyotrophic lateral sclerosis. J Neurosci Res 1994;38:336-347.
25. Ginsburg S, Martin L, Rothstein JD. Regional deafferentation down regulates subtypes of glutamate transporters. J Neurochem 1995;65:2800-2803.
26. Bristol LA, Rothstein JD. Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex. Ann Neurol 1996;39:676-679.
27. Borchelt DR, Lee MK, Slunt HH, Guarnieri M, Xu Z-S, Wong PC, Brown RH Jr, Price DL, Sisodia SS, Cleveland DW. Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc Natl Acad Sci USA 1994;91:8292-8296.
28. Beckman JS, Carson M, Smith CD, Koppenol WH. ALS, SOD and peroxynitrite [letter]. Nature 1993;364:584.
29. Ischiropoulos H, Zhu L, Chen J, Tsai M, Martin JC, Smith CD, Beckman JS. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys 1992;298:431-437.
30. Volterra A, Trotti D, Tromba C, Floridi S, Racagni G. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J Neurosci 1994;14:2924-2932.
31. Trotti D, Volterra A, Lehre KP, Rossi D, Gjesdal O, Racagni G, Danbolt NC. Arachidonic acid inhibits a purified and reconstituted glutamate transporter directly from the water phase and not via the phospholipid membrane. J Biol Chem 1995; 270:9890-9895.
32. Trotti D, Rossi D, Gjesdal O, Levy LM, Racagni G, Danbolt NC, Volterra A. Peroxynitrite inhibits glutamate transporter subtypes. J Biol Chem 1996;27:5976-5979.
33. Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kuncl RW, Kanai Y, Hediger M, Wang Y, Schielke J, Welty DF. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 1996;16:675-686.
34. Pruss RM, Akeson RL, Racke MM, Wilburn JL. Agonist-activated cobalt uptake identifies divalent cation-permeable kainate receptors on neurons and glial cells. Neuron 1991;7: 509-518.
35. Carriedo SG, Yin H, Lamberta R, Weiss JH. Neuroreport 1995;6:945-948.
36. Gurney ME, Cutting FB, Zhai P, Doble A, Taylor CP, Andrus PK, Hall ED. Benefit of vitamin E, riluzole and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann Neurol 1996;39:147-157.
37. Bowling AC, Schulz JB, Brown RH, Beal MF. Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J Neurochem 1993;61:2322-2325.
38. Shaw PJ, Ince PG, Falkous G, Mantle D. Oxidative damage to protein in sporadic motor neuron disease spinal cord. Ann Neurol 1995;38:691-695.
39. Brown RH. Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice. Cell 1995;80:687-692.
40. Rothstein JD, Tsai G, Kuncl RW, et al. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann Neurol 1990;28:18-25.