Psychological stress activates the inflammasome via release of adenosine triphosphate and stimulation of the purinergic type 2X7 receptor

Biological Psychiatry

Volumn 80, Issue 1, 2016, Pages 12-22

  Iwata, Masaaki ^a   Ota, Kristie T ^a   Li, Xiao Yuan ^a   Sakaue, Fumika ^a   Li, Nanxin ^a   Dutheil, Sophie ^a   Banasr, Mounira ^a   Duric, Vanja ^a,b   Yamanashi, Takehiko ^c   Kaneko, Koichi ^c   Rasmussen, Kurt ^d   Glasebrook, Andrew ^d   Koester, Anja ^d   Song, Dekun ^e   Jones, Kenneth A ^e   Zorn, Stevin ^e   Smagin, Gennady ^e   Duman, Ronald S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DES MOINES UNIVERSITY   (United States)

^c TOTTORI UNIVERSITY   (Japan)

^d ELI LILLY AND COMPANY   (United States)

^e LUNDBECK RESEARCH USA   (United States)

Author keywords

ATP; Depression; IL 1 ; NLRP3 inflammasome; P2X7; Stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; CRYOPYRIN; GLUTAMIC ACID; INFLAMMASOME; INTERLEUKIN 1BETA; PURINERGIC P2X7 RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; TUMOR NECROSIS FACTOR ALPHA; PURINERGIC P2Y RECEPTOR AGONIST; PURINERGIC P2Y RECEPTOR ANTAGONIST; PURINERGIC P2Y2 RECEPTOR; TUMOR NECROSIS FACTOR;

ACUTE STRESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; ASTROCYTE; CHRONIC UNPREDICTABLE STRESS; CONTROLLED STUDY; DEPRESSION; GENE DELETION; HIPPOCAMPUS; IMMOBILIZATION STRESS; MENTAL STRESS; MICRODIALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING; ANHEDONIA; ANIMAL; ANIMAL BEHAVIOR; COMPLICATION; DISEASE MODEL; IMMUNOLOGY; KNOCKOUT MOUSE; MALE; METABOLISM; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATE; ANHEDONIA; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; DEPRESSION; DISEASE MODELS, ANIMAL; INFLAMMASOMES; INTERLEUKIN-1BETA; MALE; MICE; MICE, KNOCKOUT; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PURINERGIC P2Y RECEPTOR AGONISTS; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2Y2; STRESS, PSYCHOLOGICAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84955611614     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2015.11.026     Document Type: Article

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