Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss

Pharmacology and Therapeutics

Volumn 165, Issue , 2016, Pages 153-163

  Rupasinghe, H P Vasantha ^a,b   Sekhon Loodu, Satvir ^a   Mantso, Theodora ^c   Panayiotidis, Mihalis I ^c  

^a DALHOUSIE UNIVERSITY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

^c HERIOT WATT UNIVERSITY   (United Kingdom)

Author keywords

Beta oxidation; Epigenetics; Lipid metabolism; Obesity; Phytochemicals; Weight loss

Indexed keywords

ANTHOCYANIN; CAPSAICINOID; CATECHIN; CITRUS FRUIT EXTRACT; CURCUMIN; FATTY ACID; FLAVONOID; GREEN TEA EXTRACT; HYDROXYCITRIC ACID; KETONE DERIVATIVE; PIPERINE; PLANT MEDICINAL PRODUCT; POLYPHENOL DERIVATIVE; RESVERATROL; SOYBEAN EXTRACT; UNCLASSIFIED DRUG; ANTIOBESITY AGENT;

CACAO; DRUG MECHANISM; EPIGENETICS; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; HUMAN; NONHUMAN; OBESITY; PRIORITY JOURNAL; RASPBERRY; REVIEW; WEIGHT REDUCTION; ANIMAL; DRUG EFFECTS; ENERGY METABOLISM; METABOLISM; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

ADIPOSITY; ANIMALS; ANTI-OBESITY AGENTS; ENERGY METABOLISM; FATTY ACIDS; HUMANS; OBESITY; OXIDATION-REDUCTION; PHYTOCHEMICALS; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; WEIGHT LOSS;

EID: 84984799860     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2016.06.005     Document Type: Review

References (171)

1. Aguirre, L., Fernandez-Quintela, A., Arias, N., Portillo, M.P., Resveratrol: Anti-obesity mechanisms of action. Molecules 19 (2014), 18632–18655.
2. Aires, V., Delmas, D., Le Bachelier, C., Latruffe, N., Latruffe, N., Schlemmer, D., et al. Stilbenes and resveratrol metabolites improve mitochondrial fatty acid oxidation defects in human fibroblasts. Orphanet J Rare Dis 9 (2014), 79–85.
3. Ali, F., Ismail, A., Esa, N.M., Pei, C.P., Transcriptomics expression analysis to unveil the molecular mechanisms underlying the cocoa polyphenol treatment in diet-induced obesity rats. Genomics 105 (2015), 23–30.
4. Andres-Lacueva, C., Monagas, M., Khan, N., Izquierdo-Pulido, M., et al. Flavanol and flavonol contents of cocoa powder products: Influence of the manufacturing process. J Agric Food Chem 56 (2008), 3111–3117.
5. Arbo, M.D., Lartentis, E.R., Linck, V.M., Aboy, A.L., Pimentel, A.L., Henriques, A.T., et al. Food Chem Toxicol 46 (2008), 2770–2775.
6. Arsenijevic, D., Onuma, H., Pecqueur, C., Raimbault, S., Manning, B.S., et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 26 (2000), 435–439.
7. Arts, I.C.W., Hollman, P.C.H., Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 81 (2005), S317–S325.
8. Baba, S., Osakabe, N., Natsume, M., Yasuda, A., et al. Cocoa powder enhances the level of antioxidative activity in rat plasma. Br J Nutr 84 (2000), 673–680.
9. Baur, J.A., Pearson, K.J., Price, N.L., Jamieson, N.L., Lerin, C., Kalra, A., et al. Resveratrol improves health and survival of mice on high-calorie diet. Nature 444 (2006), 337–342.
10. Benn, T., Kim, B., Park, Y.K., Wegner, C.J., Harness, E., Nam, T.G., et al. Polyphenol-rich blackcurrant extract prevents inflammation in diet-induced obese mice. J Nutr Biochem 25 (2014), 1019–1025.
11. Bessesen, D.H., Update on obesity. J Clin Endocrinol Metab 93 (2008), 2027–2034.
12. Block, G., Jensen, C.D., Norkus, E.P., Dalvi, T.B., et al. Usage patterns, health, and nutritional status of long-term multiple dietary supplement users: A cross-sectional study. Nutr J 6 (2007), 30–41.
13. Borchardt, R.T., Affinity labeling of catechol O-methyltransferase by the oxidation products of 6-hydroxydopamine. Mol Pharmacol 11 (1975), 436–449.
14. Bu, L., Setchell, K.D., Lephart, E.D., Influences of dietary soy isoflavones on metabolism but not nociception and stress hormone responses in ovariectomized female rats. Reprod Biol Endocrinol 3 (2005), 58–64.
15. Calapai, G., Firenzuoli, F., Saitta, A., Squadrito, F., Arlotta, M.R., Costantino, G., et al. Fitoterapia 70 (1999), 586–592.
16. Castañeda, A., Pacheco, H.M.L., Páez, H.M.E., Rodríguez, J.A., Galán, C.A., Chemical studies of anthocyanins: A review. Food Chem 113 (2009), 859–871.
17. Cederroth, C.R., Nef, S., Soy, phytoestrogens and metabolism: A review. Mol Cell Endocrinol 304 (2009), 30–42.
18. Cederroth, C.R., Vinciguerra, M., Gjinovci, A., Kuhne, F., Klein, M., Cederroth, M., Caille, et al. Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism. Diabetes 57 (2008), 1176–1185.
19. Cederroth, C.R., Vinciguerra, M., Kuhne, F., Madani, R., Doerge, D.R., Visser, T.J., Foti, et al. A phytoestrogen-rich diet increases energy expenditure and decreases adiposity in mice. Environ Health Perspect 115 (2007), 1467–1473.
20. Chalkiadaki, A., Guarente, L., High-fat diet triggers inflammation induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab 16 (2012), 180–188.
21. Chaput, J.-P., St-Pierre, S., Tremblay, A., Currently available drugs for the treatment of obesity: Sibutramine and orlistat. Mini Rev Med Chem 7 (2007), 3–10.
22. Cho, K.W., Kim, Y.O., Andrade, J.E., Burgess, J.R., Kim, Y.C., Dietary naringenin increases hepatic peroxisome proliferators-activated receptor alpha protein expression and decreases plasma triglyceride and adiposity in rats. Eur J Nutr 50 (2011), 81–88.
23. Chuah, L.O., Ho, W.Y., Beh, B.K., Yeap, S.K., Updates on antiobesity effect of Garcinia origin (−)-HCA. Evid Based Complement Alternat Med, 2013, 2013, 751658.
24. Chung, J.H., Using PDE inhibitors to harness the benefits of calorie restriction: Lessons from resveratrol. Aging 4 (2012), 144–145.
25. Chung, J.H., Manganiello, V., Dyck, J.R., Resveratrol as a calorie restriction mimetic: Therapeutic implications. Trends Cell Biol 22 (2012), 546–554.
26. Cornelius, P., MacDougald, O.A., Lane, M.D., Regulation of adipocyte development. Annu Rev Nutr 14 (1994), 99–129.
27. Corti, R., Flammer, A.J., Hollenberg, N.K., Lüscher, T.F., Cocoa and cardiovascular health. Circulation 119 (2009), 1433–1441.
28. Crescenti, A., Sola, R., Valls, R.M., Caimari, A., Del Bas, J.M., Anguera, A., et al. Cocoa consumption alters the global DNA methylation of peripheral leukocytes in humans with cardiovascular disease risk factors: A randomized controlled trial. PLoS One, 8, 2013, e65744.
29. Dal-Pan, A., Blanc, S., Aujard, F., Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity. BMC Physiol 10 (2010), 11–21.
30. Dal-Pan, A., Terrien, J., Pifferi, F., Botalla, R., et al. Caloric restriction or resveratrol supplementation and ageing in a non-human primate: First-year outcome of the RESTRIKAL study in Microcebus murinus. Age (Dordr) 33 (2011), 15–31.
31. Diepvens, K., Westerterp, K.R., Westerterp-Plantenga, M.S., Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol 292 (2007), 77–85.
32. Drenska, D., Banttutova, I., Oveharov, R., Anticonvulsant effect of anthocyanins and antioxidants. Fomatsiya (Sofia), Vol. 30, 1989, 33–40.
33. Eaton, S., Bartlett, K., Quant, P.A., Carnitine palmitoyltransferase I and the control of beta-oxidation in heart mitochondria. Biochem Biophys Res Commun 285 (2001), 537–539.
34. Ejaz, A., Wu, D., Kwan, P., Meydani, M., Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J Nutr 139 (2009), 919–925.
35. Faraut, B., Giannesini, B., Matarazzo, V., Le Fur, Y., Rougon, G., Cozzone, P.J., et al. Capsiate administration results in an uncoupling protein-3 downregulation, an enhanced muscle oxidative capacity and a decreased abdominal fat content in vivo. Int J Obes 33 (2009), 1348–1355.
36. Farhat, G., Drummond, S., Fyfe, L., Al-Dujaili, E.A.S., Dark chocolate: An obesity paradox or a culprit for weight gain?. Phytother Res 28 (2014), 791–797.
37. Faulds, M.H., Dahlman, W.K., Metabolic diseases and cancer risk. Curr Opin Oncol 24 (2012), 58–61.
38. Field, D.T., Williams, C.M., Butler, L.T., Consumption of cocoa flavanols results in an acute improvement in visual and cognitive functions. Physiol Behav 103 (2011), 255–260.
39. Filozof, C.M., Murua, C., Sanchez, M.P., Brailovsky, C., Perman, M., Gonzalez, C.D., et al. Low plasma leptin concentration and low rates of fat oxidation in weight-stable post-obese subjects. Obes Res 8 (2000), 205–210.
40. Friedman, M.I., Obesity and the hepatic control of feeding behavior. Drug News Perspect 20 (2007), 573–578.
41. Galleano, M., Oteiza, P., Fraga, C., Cocoa, chocolate and cardiovascular disease. J Cardiovasc Pharmacol 54 (2009), 483–490.
42. Goldwasser, J., Cohen, P.Y., Yang, E., Balaguer, P., Yarmush, M.L., Nahmias, Y., Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: Role of PPARalpha, PPARgamma and LXRalpha. PLoS One, 5, 2010, e12399.
43. Gong, D.W., Monemdjou, S., Gavrilova, O., Leon, L.R., Marcus-Samuels, B., et al. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem 275 (2000), 16251–16257.
44. González-Castejón, M., Rodriguez-Casado, A., Dietary phytochemicals and their potential effects on obesity: A review. Pharmacol Res 64 (2011), 438–455.
45. Gracia, A., Elcoroaristizabal, X., Fernandez-Quintela, A., Miranda, J., Bediaga, N.G., et al. Fatty acid synthase methylation levels in adipose tissue: Effects of an obesogenic diet and phenol compounds. Genes Nutr 9 (2014), 411–420.
46. Grassi, D., Lippi, C., Necozione, S., et al. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr 81 (2005), 611–614.
47. Gu, Y., Yu, S., Lambert, J., Dietary cocoa ameliorates obesity-related inflammation in high in high fat-fed mice. Eur J Nutr 53 (2014), 149–158.
48. Guarente, L., Sirtuins as potential targets for metabolic syndrome. Nature 444 (2006), 868–874.
49. Guo, Y., Su, Z.Y., Kong, A.T., Current perspectives on epigenetic modifications by dietary chemopreventive and herbal phytochemicals. Curr Pharmacol Rep 1 (2015), 245–257.
50. Hallows, W.C., Lee, S., Denu, J.M., Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A 103 (2006), 10230–10235.
51. Hallows, W.C., Yu, W., Smith, B.C., Devires, M.K., Ellinger, J.J., et al. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol Cell 41 (2011), 139–149.
52. Hamed, M.S., Gambert, S., Bliden, K.P., et al. Dark chocolate effect on platelet activity, C-reactive protein and lipid profile: A pilot study. South Med J 101 (2008), 1203–1208.
53. Harada, N., Okajima, K., Narimatsu, N., Kurihara, H., Nakagata, N., Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans. Growth Hormon IGF Res 18 (2008), 335–344.
54. Haramizu, S., Mizunoya, W., Masuda, Y., Ohnuki, K., Watanabe, T., Yazawa, S., Fushiki, T., Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors. Biosci Biotechnol Biochem 70 (2006), 774–781.
55. Hirschey, M.D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 464 (2010), 121–125.
56. Horton, R.A., Moran, L.A., Scrimgeour, G., Perry, M., Rawn, D., Principles of Biochemistry. 4th, Fourth ed., 2006, Pearson, Glenview, IL, USA.
57. Hou, X., Xu, S., Maitland-Toolan, K.A., Sato, K., Jiang, B., et al. SIRT1 regulates hepatocyte lipid metabolism through activating AMP activated protein kinase. J Biol Chem 283 (2008), 20015–20026.
58. Howard, T.D., Ho, S.M., Zhang, L., Chen, J., Cui, W., Slager, R.,.. Wagner, J.D., Epigenetic changes with dietary soy in cynomolgus monkeys. PLoS One, 6, 2011, e26791.
59. Huang, C.C., Tung, Y.T., Huang, W.C., Chen, Y.M., Hsu, Y.J., Hsu, M.C., Beneficial effects of cocoa, coffee, green tea, and Garcinia complex supplement on diet induced obesity in rats. BMC Complement Altern Med 16 (2016), 100–110.
60. Huong, D.T.T., Takahashi, Y., Ide, T., Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids. Nutrition 22 (2006), 546–552.
61. 2 +/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem 280 (2005), 29060–29066.
62. Hwang, J.T., Park, I.J., Shin, J.I., Lee, Y.K., Lee, S.K., Baik, H.W., et al. Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochem Biophys Res Commun, 338, 2005, 694-649.
63. Ishihara, K., Oyaizu, S., Onuki, K., Lim, K., Fushiki, T., Chronic (−)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J Nutr 130 (2000), 2990–2995.
64. Jang, E.M., Choi, M.S., Jung, U.J., et al. Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fatfed hamsters. Metabolism 57 (2008), 1576–1583.
65. Jayaprakasam, B., Olson, L.K., Schutzki, R.E., Tai, M.H., Nair, M.G., Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem 11 (2006), 243–248.
66. Jeon, S.M., Lee, S.A., Choi, M.S., Antiobesity and vasoprotective effects of resveratrol in apoE-deficient mice. J Med Food 17 (2014), 310–316.
67. Jeukendrup, A.E., Randell, R., Fat burners: Nutrition supplements that increase fat metabolism. Obes Rev 12 (2011), 841–851.
68. Jiang, A., Wang, X., Shan, X., Li, Y., Wang, P., Jiang, P., Feng, Q., Curcumin reactivates silenced tumor suppressor gene RARbeta by reducing DNA methylation. Phytother Res 29 (2015), 1237–1245.
69. Jung, U.J., Lee, M.K., Park, Y.B., Kang, M.A., Choi, M.S., Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol 38 (2006), 1134–1145.
70. Kahn, B.B., Alquier, T., Carling, D., Hardie, D.G., AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1 (2005), 15–25.
71. Kamphuis, M.M., Mela, D.J., Westerterp-Plantenga, M.S., Diacylglycerols affect substrate oxidation and appetite in humans. Am J Clin Nutr 77 (2003), 1133–1139.
72. Kang, S.I., Shin, H.S., Kim, H.M., Hong, Y.S., Yoon, S.A., Kang, S.W., et al. Immature citrus sunki peel extract exhibits antiobesity effects by β-oxidation and lipolysis in high-fat diet-induced obese mice. Biol Pharm Bull 35 (2012), 223–230.
73. Katz, D., Doughty, K., Ather, A., Cocoa and chocolate in human health and disease. Antioxid Redox Signal 15 (2011), 2779–2811.
74. Kaume, L., Gilbert, W.C., Brownmiller, C., Howard, L.R., Devareddy, L., Cyanidin 3-O-β-D-glucoside-rich blackberries modulate hepatic gene expression and anti-obesity effects in ovariectomized rats. J Funct Foods 4 (2012), 480–488.
75. Kawada, T., Kawada, T., Suzuki, T., Takahashi, M., Iwai, K., Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats. Toxicol Appl Pharmacol 72 (1984), 449–456.
76. Kawada, T., Watanabe, T., Takaishi, T., Tanaka, T., Iwai, K., Capsaicin- induced beta-adrenergic action on energy metabolism in rats: Influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization. Proc Soc Exp Biol Med 183 (1986), 250–256.
77. Kim, S., Shin, H.-J., Kim, S.Y., Kim, J.H., et al. Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPAR. Mol Cell Endocrinol 220 (2004), 51–58.
78. Kim, S., Sohn, I., Lee, Y.S., Lee, Y.S., Hepatic gene expression profiles are altered by genistein supplementation in mice with diet-induced obesity. J Nutr 135 (2004), 33–41.
79. Kim, H.K., Nelson-Dooley, C., Della-Fera, M.A., Yang, J.Y., Zhang, W., Duan, J., et al. Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice. J Nutr 136 (2006), 409–414.
80. Koide, T., Hashimoto, Y., Kamei, H., Kojima, T., Hasegawa, M., Terabe, K., Antitumor effect of anthocyanin fractions extracted from red soybeans and red beans in vitro and in vivo. Cancer Biother Radiopharm 12 (1997), 277–280.
81. Kovacs, E.M.R., Westerterp-Plantenga, M.S., Effects of (−)-hydroxycitrate on net fat synthesis as de novo lipogenesis. Physiol Behav 88 (2006), 371–381.
82. Kozukue, N., Han, J.-S., Kozukue, E., Lee, S.-J., Kim, J.-A., Lee, K.-R.,.. Friedman, M., Analysis of eight capsaicinoids in peppers and pepper-containing foods by high-performance liquid chromatography and liquid chromatography–mass spectrometry. J Agric Food Chem 53 (2005), 9172–9181.
83. Kuiper, G.G., Carlsson, B., Grandien, K., Enmark, E., Haggblad, J., Nilsson, S., et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138 (1997), 863–870.
84. Kumar, M.V., Sunvold, G.D., Scarpace, P.J., Dietary vitamin a supplementation in rats: Suppression of leptin and induction of UCP1 mRNA. J Lipid Res 40 (1999), 824–829.
85. Kurlandsky, S.B., Stote, K.S., Cardioprotective effects of chocolate and almond consumption in healthy women. Nutr Res 26 (2006), 509–516.
86. Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127 (2006), 1109–1122.
87. Langin, D., Control of fatty acid and glycerol release in adipose tissue lipolysis. C R Biol 329 (2006), 598–607.
88. Lee, L.S., Choi, J.H., Sung, M.J., Hur, J.Y., Hur, H.J., Park, J.D., et al. Green tea changes serum and liver metabolomic profiles in mice with high-fat diet-induced obesity. Mol Nutr Food Res 59 (2015), 784–794.
89. Lee, M.S., Kim, C.T., Kim, Y., Green tea (−)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice. Ann Nutr Metab 54 (2009), 151–157.
90. Lee, M.S., Kim, C.T., Kim, I.H., Kim, Y., Effects of capsaicin on lipid catabolism in 3T3-L1 adipocytes. Phytother Res 25 (2011), 935–939.
91. Lee, W.J., Koh, E.H., Won, J.C., Kim, M.-S., Park, J.-Y., et al. Obesity: The role of hypothalamic AMP-activated protein kinase in body weight regulation. Int J Biochem Cell Biol 37 (2005), 2254–2259.
92. Lejeune, M.P., Kovacs, E.M., Westerterp-Plantenga, M.S., Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects. Br J Nutr 90 (2003), 651–659.
93. Leonhardt, M., Langhans, W., Hydroxycitrate has long-term effects on feeding behavior, body weight regain and metabolism after body weight loss in male rats. J Nutr 132 (2002), 1977–1982.
94. Lephart, E.D., Setchell, K.D., Handa, R.J., Lund, T.D., Behavioral effects of endocrine-disrupting substances: Phytoestrogens. ILAR J 45 (2004), 443–454.
95. Lopaschuk, G.D., Ussher, J.R., Folmes, C.D., Jaswal, J.S., Stanley, W.C., Myocardial fatty acid metabolism in health and disease. Physiol Rev 90 (2010), 207–258.
96. Maeda, N., Takahashi, M., Funahashi, T., Kihara, S., et al. PPAR ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 50 (2001), 2094–2098.
97. Manach, C., Scalbert, A., Morand, C., Remesy, C., et al. Polyphenols: Food sources and bioavailability. Am J Clin Nutr 79 (2004), 727–747.
98. Maples, J.M., Brault, J.J., Shewchuk, B.M., Witczak, C.A., Zou, K., Rowland, N., et al. Lipid exposure elicits differential responses in gene expression and DNA methylation in primary human skeletal muscle cells from severely obese women. Physiol Genomics 47 (2015), 139–146.
99. Maples, J.M., Brault, J.J., Witczak, C.A., Park, S., Hubal, M.J., Weber, T.M., et al. Differential epigenetic and transcriptional response of the skeletal muscle carnitine palmitoyltransferase 1B (CPT1B) gene to lipid exposure with obesity. Am J Physiol Endocrinol Metab 309 (2015), E345–E356.
100. Masuda, Y., Haramizu, S., Oki, K., Ohnuki, K., Watanabe, T., Yazawa, S., et al. Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog. J Appl Physiol 95 (2003), 2408–2415.
101. Matsui, T., Ueda, T., Oki, T., Sugita, K., Terahara, N., Matsumoto, K., Alpha-glucosidase inhibitory action of natural acylated anthocyanins: Survey of natural pigments with potent inhibitory activity. J Agric Food Chem 49 (2001), 1948–1951.
102. McGarry, J.D., Brown, N.F., The mitochondrial carnitine palmitoyltransferase system: From concept to molecular analysis. Eur J Biochem 244 (1997), 1–14.
103. McGarry, J.D., Mills, S.E., Long, C.S., Foster, D.W., Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Biochem J 214 (1983), 21–28.
104. Meng, X.J., Zhou, Y., Liu, X., Zheng, F., Experimental study on the anti-obesity action of simple obesity in rats by raspberry ketone. Food Ind 1 (2008), 1–3.
105. Minokoshi, Y., Kim, Y.B., Peroni, O.D., Fryer, L.G., Müller, C., Carling, D., et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 17 (2002), 339–343.
106. Morimoto, C., Satoh, Y., Hara, M., Inoue, S., Tsujita, T., Okuda, H., Anti-obese action of raspberry ketone. Life Sci 27 (2005), 194–204.
107. Mullen, K.L., Smith, A.C., Junkin, K.A., Dyck, D.J., Globular adiponectin resistance develops independently of impaired insulin-stimulated glucose transport in soleusmuscle from high-fat-fed rats. Am J Physiol Endocrinol Metab 293 (2007), E83–E90.
108. Mulvihill, E.E., Allister, E.M., Sutherland, B.G., et al. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes 58 (2009), 2198–2210.
109. Mulvihill, E.E., Assini, J.M., Lee, J.K., et al. Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance. Diabetes 60 (2011), 1446–1457.
110. Nogueira, L., Ramirez-Sanchez, I., Perkins, G., et al. (−)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol 589 (2011), 4615–4631.
111. Oh, H.G., Kang, Y.R., Lee, H.Y., Kim, J.H., Shin, E.H., Lee, B.G., et al. Ameliorative effects of Monascus pilosus — fermented black soybean (Glycine max L. Merrill) on high-fat diet-induced obesity. J Med Food 17 (2014), 972–978.
112. Ohara, K., Uchida, A., Nagasaka, R., Ushio, H., Ohshima, T., The effects of hydroxycinnamic acid derivatives on adiponectin secretion. Phytomedicine 16 (2009), 130–137.
113. Ohnuki, K., Haramizu, S., Oki, K., Watanabe, T., Yazawa, S., Fushiki, T., Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice. Biosci Biotechnol Biochem 65 (2001), 2735–2740.
114. Ohnuki, K., Niwa, S., Maeda, S., Inoue, N., Yazawa, S., Fushiki, T., CH-19 sweet, a non-pungent cultivar of red pepper, increased body temperature and oxygen consumption in humans. Biosci Biotechnol Biochem 65 (2001), 2033–2036.
115. O'Neill, H.M., AMPK and exercise: Glucose uptake and insulin sensitivity. Diabetes Metab J 37 (2013), 1–21.
116. Park, K.S., Raspberry ketone increases noth lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med 76 (2010), 1654–1658.
117. Park, S.J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148 (2012), 421–433.
118. Park, U.H., Jeong, H.S., Jo, E.Y., Park, T., Yoon, S.K., Kim, E.J., et al. Piperine, a component of black pepper, inhibits adipogenesis by antagonizing PPARgamma activity in 3T3-L1 cells. J Agric Food Chem 60 (2012), 3853–3860.
119. Prakash, U.N., Srinivasan, K., Fat digestion and absorption in spice-pretreated rats. J Sci Food Agric 92 (2012), 503–510.
120. Preuss, H.G., Bagchi, D., Bagchi, M., Rao, C.V.S., Dey, D.K., Satyanarayana, S., Effects of a natural extract of (−)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 6 (2004), 171–180.
121. Prior, R.L., Wilkes, E.S.R., Rogers, T., Khanal, R.C., Wu, X., et al. Purified blueberry anthocyanins and blueberry juice alter development of obesity in mice fed an obesogenic high-fat diet. J Agric Food Chem 58 (2012), 3970–3976.
122. Prior, R.L., Wu, X., Gu, L., Hager, T.J., Hager, A., et al. Whole berries versus berry anthocyanins: Interactions with dietary fat levels in the C57BL/6J mouse model of obesity. J Agric Food Chem 56 (2008), 647–653.
123. Purushotham, A., Schug, T.T., Xu, Q., Surapureddi, S., Guo, X., et al. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab 9 (2009), 327–338.
124. Ravai, M., Quality characteristics of raspberries and blackberries. Cereal Foods World 41 (1996), 773–775.
125. Reinbach, H.C., Smeets, A., Martinussen, T., Moller, P., Westerterp-Plantenga, M.S., Effects of capsaicin, green tea and CH-19 sweet pepper on appetite and energy intake in humans in negative and positive energy balance. Clin Nutr 28 (2009), 260–265.
126. Rivera, L., Morón, R., Zarzuelo, A., Galisteo, M., Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochem Pharmacol 77 (2009), 1053–1063.
127. Rogge, M.M., The role of impaired mitochondrial lipid oxidation in obesity. Biol Res Nurs 10 (2009), 356–373.
128. Ronnett, G.V., Kim, E.K., Landree, L.E., Tu, Y., Fatty acid metabolism as a target for obesity treatment. Physiol Behav 19 (2005), 25–35.
129. Rousset, S., Alves-Guerra, M.C., Mozo, J., et al. The biology of mitochondrial uncoupling proteins. Diabetes 53 (2004), S130–S135.
130. Rupasinghe, H.P.V., Jackson, C.-J.C., Poysa, V., Berardo, C.D., Bewley, J.D., Jenkinson, J., Soyasapogenol A and B distribution in soybean (Glycine max L. Merr.) in relation to seed physiology, genetic variability, and growing location. J Agric Food Chem 51 (2003), 5888–5894.
131. Sacks, F.M., Lichtenstein, A., Van Horn, L., Harris, W., Kris-Etherton, P., Winston, M., Soy protein, isoflavones, and cardiovascular health: An American Heart Association Science Advisory for professionals from the Nutrition Committee. Circulation 113 (2006), 1034–1044.
132. Salas-Salvado, J., Martinez-Gonzalez, M.A., Bullo, M., Ros, E., The role of diet in the prevention of type 2 diabetes. Nutr Metab Cardiovasc Dis 21 (2011), B32–B48.
133. Sancho, R.A.S., Pastore, G.M., Evaluation of the effects of anthocyanins in type 2 diabetes. Food Res Int 46 (2012), 378–386.
134. Satue-Gracia, M.T., Heinonen, M., Frankel, E.N., Anthocyanins as antioxidants on human low-density lipoprotein and lecithin–liposome systems. J Agric Food Chem 45 (1997), 3362–3367.
135. Setchell, K.D., Phytoestrogens: The biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 68 (1998), 1333S–1346S.
136. Shang, J., Chen, L.L., Xiao, F.X., Sun, H., Ding, H.C., Xiao, H., Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase. Acta Pharmacol Sin 29 (2008), 698–706.
137. Shankar, S., Kumar, D., Srivastava, R.K., Epigenetic modifications by dietary phytochemicals: Implications for personalized nutrition. Pharmacol Ther 138 (2013), 1–17.
138. Sharma, S., Kelly, T.K., Jones, P.A., Epigenetics in cancer. Carcinogenesis 31 (2010), 27–36.
139. Shen, K., Xie, J., Wang, H., Zhang, H., Yu, M., Lu, F., et al. Cambogin induces caspase-independent apoptosis through the ROS/JNK pathway and epigenetic regulation in breast cancer cells. Mol Cancer Ther 14 (2015), 1738–1749.
140. Simoneau, J.A., Veerkamp, J.H., Turcotte, L.P., Kelley, D.E., Markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance and obesity and effects of weight loss. FASEB J 13 (1999), 2051–2060.
141. Smith, S., The animal fatty acid synthase: One gene, one polypeptide, seven enzymes. FASEB J 8 (1994), 1248–1259.
142. Stark, T., Bareuther, S., Hofmann, T., Molecular definition of the taste of roasted cocoa nibs (Theobroma cacao) by means of quantitative studies and sensory experiments. J Agric Food Chem 54 (2006), 5530–5539.
143. Su, Z.Y., Shu, L., Khor, T.O., Lee, J.H., Fuentes, F., Kong, A.N., A perspective on dietary phytochemicals and cancer chemoprevention: Oxidative stress, nrf2, and epigenomics. Top Curr Chem 329 (2013), 133–162.
144. Sun, Y., Mukai, Y., Tanaka, M., Saito, T., Sato, S., Kurasaki, M., Green tea extract increases mRNA expression of enzymes which influence epigenetic marks in newborn female offspring from undernourished pregnant mother. PLoS One, 8, 2013, e74559.
145. Szarc vel Szic, K., Declerck, K., Vidakovic, M., Vanden Berghe, W., From inflammaging to healthy aging by dietary lifestyle choices: Is epigenetics the key to personalized nutrition?. Clin Epigenetics 7 (2015), 33–39.
146. Szkudelska, K., Szkudelski, T., Resveratrol, obesity and diabetes. Eur J Pharmacol 635 (2010), 1–8.
147. Szkudelska, K., Nogowski, L., Szkudelski, T., Genistein affects lipogenesis and lipolysis in isolated rat adipocytes. J Steroid Biochem Mol Biol 75 (2000), 265–271.
148. Tan, S., Bing Gao, B., Tao, Y., Guo, J., Su, Z.Q., Antiobese effects of capsaicin–chitosan microsphere (CCMS) in obese rats induced by high fat diet. J Agric Food Chem 62 (2014), 1866–1874.
149. Tham, D.M., Gardner, C.D., Haskell, W.L., Clinical review 97: Potential health benefits of dietary phytoestrogens: A review of the clinical, epidemiological and mechanistic evidence. J Clin Endocrinol Metab 83 (1998), 2223–2235.
150. Titta, L., Trinei, M., Stendardo, M., Berniakovich, I., Petroni, I., et al. Blood orange juice inhibits fat accumulation in mice. Int J Obes 34 (2010), 578–588.
151. Tsuda, T., Horio, F., Uchida, K., Aoki, H., Osawa, T., Dietary cyaniding 3-O-D-glucoside rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 133 (2003), 2125–2130.
152. Tziomalos, K., Krassas, G.E., Tzotzas, T., The use of sibutramine in the management of obesity and related disorders: An update. Vasc Health Risk Manag 5 (2009), 441–452.
153. Velasquez, M.T., Bhathena, S.J., Role of dietary soy protein in obesity. Int J Med Sci 4 (2007), 72–82.
154. Wang, L., Meng, X., Zhang, F., Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food 15 (2012), 495–503.
155. Wang, S., Moustaid-Moussa, N., Chen, L., Mo, H., Shastri, A., Su, R., et al. Novel insights of dietary polyphenols and obesity. J Nutr Biochem 25 (2014), 1–18.
156. Wang, H., Nair, M.G., Strasburg, G.M., Chang, Y.C., Booren, A.M., Gray, J.I., DeWitt, D.L., Antioxidant and anti-inflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. J Nat Prod 62 (1999), 294–296.
157. Watanabe, T., Kawada, T., Yamamoto, M., Iwai, K., Capsaicin, a pungent principle of hot red pepper, evokes catecholamine secretion from the adrenal medulla of anesthetized rats. Biochem Biophys Res Commun 142 (1987), 259–264.
158. WHO, Obesity: Preventing and managing the global epidemic. World Health Organization: Geneva, Switzerland 894 (2000), 1–252.
159. Witkamp, R.F., Current and future drug targets in weight management. Pharm Res 28 (2011), 1792–1818.
160. Wolf, G., Adiponectin: A regulator of energy homeostasis. Nutr Rev 61 (2003), 290–292.
161. Wu, T., Qi, X., Liu, Y., Guo, J., Zhu, R., et al. Dietary supplementation with purified mulberry (Morus australis Poir) anthocyanins suppresses body weight gain in high fat diet fed C57BL/6 mice. Food Chem 141 (2013), 482–487.
162. Wu, T., Tang, Q., Gao, Z., Yu, Z., Song, H., Zheng, X., et al. Blueberry and mulberry juice prevent obesity development in C57BL/6 mice. PLoS One, 2013, e77585, 10.1371/journal.pone.0077585.
163. Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelman, t G., Mootha, V., et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98 (1999), 115–124.
164. Yamashita, Y., Okabe, M., Natsume, M., Ashida, H., Prevention mechanisms of glucose intolerance and obesity by cacao liquor procyanidin extract in high-fat diet-fed C57BL/6 mice. Arch Biochem Biophys 527 (2012), 95–104.
165. Yoshioka, K., Lim, K., Kikuzato, S., Kiyonaga, A., Tanaka, H., et al. Effects of red-pepper diet on the energy metabolism in men. J Nutr Sci Vitaminol 41 (1995), 647–656.
166. Yun, J.W., Possible anti-obesity therapeutics from nature — A review. Phytochem 71 (2010), 1625–1641.
167. Zammit, V.A., The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function. Biochem J 343 (1999), 505–515.
168. Zang, Y., Zhang, L., Igarashi, K., Yu, C., The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice. Food Funct 6 (2015), 834–841.
169. Zhao, J., Sun, X.B., Ye, F., Tian, W.X., Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin. Mol Cell Biochem 351 (2011), 19–28.
170. Zheng, G., Sayama, K., Okubo, T., et al. Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice. In Vivo 18 (2004), 55–62.
171. Zingg, J.M., Hasan, S.T., Meydani, M., Molecular mechanisms of hypolipidemic effects of curcumin. Biofactors 39 (2013), 101–121.