Dietary cocoa ameliorates obesity-related inflammation in high fat-fed mice

European Journal of Nutrition

Volumn 53, Issue 1, 2014, Pages 149-158

  Gu, Yeyi ^a   Yu, Shan ^a   Lambert, Joshua D ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Cocoa; Inflammation; Obesity; Polyphenols; Theobroma cacao

Indexed keywords

ADIPONECTIN; ADIPOSE TISSUE, WHITE; ANIMALS; CACAO; CHEMOKINE CCL2; DIET, HIGH-FAT; ENERGY INTAKE; FATTY LIVER; INFLAMMATION; INSULIN RESISTANCE; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-6; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; NITRIC OXIDE SYNTHASE TYPE II; OBESITY; RECEPTORS, CELL SURFACE; TRIGLYCERIDES; WEIGHT GAIN;

EID: 84895073476     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-013-0510-1     Document Type: Article

References (38)

1. González-Castejón M, Rodriguez-Casado A (2011) Dietary phytochemicals and their potential effects on obesity: a review. Pharmacol Res 64:438-455
2. Finkelstein EA, Khavjou OA, Thompson H, Trogdon JG, Pan L, Sherry B, Dietz W (2012) Obesity and severe obesity forecasts through 2030. Am J Prev Med 42:563-570
3. Terra X, Pallarés V, Ardèvol A, Bladé C, Fernández-Larrea J, Pujadas G, Salvadó J, Arola L, Blay M (2011) Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats. J Nutr Biochem 22:380-387
4. Emanuela F, Grazia M, Marco DR, Maria Paola L, Giorgio F, Marco B (2012) Inflammation as a link between obesity and metabolic syndrome. J Nutr Metab 2012:476380
5. Wellen KE, Hotamisligil GS (2003) Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 112:1785-1788
6. Terra X, Montagut G, Bustos M, Llopiz N, Ardèvol A, Bladé C, Fernández-Larrea J, Pujadas G, Salvadó J, Arola L, Blay M (2009) Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet. J Nutr Biochem 20:210-218
7. Kanamoto Y, Yamashita Y, Nanba F, Yoshida T, Tsuda T, Fukuda I, Nakamura-Tsuruta S, Ashida H (2011) A black soybean seed coat extract prevents obesity and glucose intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed mice. J Agric Food Chem 59:8985-8993
8. Weisberg SP, Mccann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808
9. Khandekar MJ, Cohen P, Spiegelman BM (2011) Molecular mechanisms of cancer development in obesity. Nat Rev Cancer 11:886-895
10. Eder K, Baffy N, Falus A (2009) The major inflammatory mediator interleukin-6 and obesity. Inflamm Res 58:727-736
11. Clément S, Juge-Aubry C, Sgroi A, Conzelmann S, Pazienza V, Pittet-Cuenod B, Meier CA, Negro F (2008) Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes. Hepatol 48:799-807
12. Grassi D, Necozione S, Lippi C, Croce G, Valeri L, Pasqualetti P, Desideri G, Blumberg JB, Ferri C (2005) Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Hypertension 46:398-405
13. Selmi C, Mao TK, Keen CL, Schmitz HH, Gershwin ME (2006) The anti-inflammatory properties of cocoa flavanols. Inflammation 47:163-171
14. Cooper KA, Donovan JL, Waterhouse AL, Williamson G (2008) Cocoa and health: a decade of research. Br J Nutr 99:1-11
15. Monagas M, Khan N, Andres-Lacueva C, Casas R, Urpí-Sardà M, Llorach R, Lamuela-Raventós RM, Estruch R (2009) Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease. Am J Clin Nutr 90:1144-1150
16. Ruzaidi A, Amin I, Nawalyah AG, Hamid M, Faizul HA (2005) The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats. J Ethnopharmacol 98:55-60
17. Matsui N, Ito R, Nishimura E, Yoshikawa M, Kato M, Kamei M, Shibata H, Matsumoto I, Abe K, Hashizume S (2005) Ingested cocoa can prevent high-fat diet-induced obesity by regulating the expression of genes for fatty acid metabolism. Nutrition 21:594-601
18. Tomaru M, Takano H, Osakabe N, Yasuda A, Inoue K, Yanagisawa R, Ohwatari T, Uematsu H (2007) Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice. Nutrition 23:351-355
19. Jalil AMM, Ismail A, Pei CP, Hamid M, Kamaruddin SHS (2008) Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obese-diabetic (Ob-db) rats. J Agric Food Chem 56:7877-7884
20. Yamashita Y, Okabe M, Natsume M, Ashida H (2012) Prevention mechanisms of glucose intolerance and obesity by cacao liquor procyanidin extract in high-fat diet-fed C57BL/6 mice. Arch Biochem Biophys 2012:1-10
21. Mao T, Water JVD, Keen CL, Schmitz HH, Gershwin ME (2000) Cocoa Procyanidins and Human Cytokine Transcription and Secretion. J Nutr 130:2093-2099
22. Mao TK, Powell J, Water JVD, Keen CL, Schmitz HH, John F, Gershwin ME (2000) The Effect of cocoa procyanidins on the transcription and secretion of interleukin 1beta in peripheral blood mononuclear cells. Life Sci 66:1377-1386
23. Mao TK, van de Water J, Keen CL, Schmitz HH, Gershwin ME (2002) Modulation of TNF-α secretion in peripheral blood mononuclear cells by cocoa flavanols and procyanidins. Dev Immunol 9:135-141
24. Ramiro E, Franch A, Castellote C, Pérez-Cano F, Permanyer J, Izquierdo-Pulido M, Castell M (2005) Flavonoids from theobroma cacao down-regulate inflammatory mediators. J Agric Food Chem 53:8506-8511
25. Kenny TP, Keen CL, Schmitz HH, Gershwin ME, Enny THPK, Een CARLLK, Chmitz HAHS (2007) Immune effects of procyanidin oligomers on peripheral blood mononuclear cells. Exp Biol Med 232:293-300
26. Gu Y, Hurst WJ, Stuart DA, Lambert JD (2011) Inhibition of key digestive enzymes by cocoa extracts and procyanidins. J Agric Food Chem 59:5305-5311
27. Kelm MA, Johnson JC, Robbins RJ, Hammerstone JF, Schmitz HH (2006) High-performance liquid chromatography separation and purification of cacao (Theobroma cacao L.) procyanidins according to degree of polymerization using a diol stationary phase. J Agric Food Chem 54:1571-1576
28. Mlinar B, Marc J, Janez A, Peifer M (2007) Molecular mechanisms of insulin resistance and associated diseases. Clin Chim Acta 375:20-35
29. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830
30. Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR (2007) Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 56:16-23
31. Trayhurn P, Wood IS (2005) Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 33:1078-1081
32. Grassi D, Lippi C, Necozione S, Desideri G, Ferri C (2005) Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr 81:611-614
33. de Luca C, Olefsky JM (2008) Inflammation and insulin resistance. FEBS Lett 582:97-105
34. Shoelson SE, Lee J, Goldfine AB (2006) Inflammation and insulin resistance. J Clin Invest 116:1793-1801
35. Olefsky JM, Glass CK (2010) Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72:219-246
36. Clark J, Brancati F, Diehl A (2003) The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 98:960-967
37. Schindhelm RK, Diamant M, Dekker JM, Teerlink T, Heine RJ (2006) Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease. Diabetes Metab Res Rev 22:437-443
38. Buechler C, Wanninger J, Neumeier M (2011) Adiponectin, a key adipokine in obesity related liver diseases. World J Gastroenterol 17:2801-28011