Fatty acid metabolism as a target for obesity treatment

Physiology and Behavior

Volumn 85, Issue 1, 2005, Pages 25-35

  Ronnett, Gabriele V ^a   Kim, Eun Kyoung ^a   Landree, Leslie E ^a   Tu, Yajun ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

C75; Carnitine palmitoyltranseferase 1; Energy expenditure; Fatty acid synthase; Obesity; Weight loss

Indexed keywords

ACETYL COENZYME A; CARNITINE PALMITOYLTRANSFERASE; CERULETIDE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LONG CHAIN FATTY ACID; MALONYL COENZYME A; NEUROPEPTIDE Y; OREXIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROTEIN C FOS; THIOCTIC ACID;

ACYLATION; ANOREXIA; APOPTOSIS; CALORIMETRY; CATALYSIS; CEPHALOSPORIUM; DRUG EFFECT; DRUG MECHANISM; ENERGY BALANCE; ENERGY CONSUMPTION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FOOD INTAKE; GENE EXPRESSION; HUMAN; HYPOTHALAMUS; LIPOGENESIS; MITOCHONDRION; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVIEW; WEIGHT REDUCTION;

EID: 19744377649     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2005.04.014     Document Type: Article

References (104)

1. H.E. Bays Current and investigational antiobesity agents and obesity therapeutic treatment targets Obes Res 12 2004 1197 1211
2. S.M. Gale, V.D. Castracane, and C.S. Mantzoros Energy homeostasis, obesity and eating disorders: recent advances in endocrinology J Nutr 134 2004 295 298
3. P.M. Hellstrom, A. Geliebter, E. Naslund, P.T. Schmidt, E.K. Yahav, and S.A. Hashim Peripheral and central signals in the control of eating in normal, obese and binge-eating human subjects Br J Nutr 92 Suppl. 1 2004 S47 S57
4. S. Woods, R. Seeley, D.J. Porte, and M. Schwartz Signals that regulate food intake and energy homeostasis Science 280 1998 1378 1383
5. P.J. Magistretti Brain energy metabolism Fundamental neuroscience 1999 Academic Press 389 411
6. M. Schwartz, S. Woods, D.J. Porte, R. Seeley, and D. Baskin Central nervous system control of food intake Nature 404 2000 661 671
7. B.M. Spiegelman, and J.S. Flier Obesity and the regulation of energy balance Cell 104 2001 531 543
8. P.J. Magistretti, L. Pellerin, D. Rothman, and R. Shulman Energy on demand Science 283 1999 496 497
9. E.K. Kim, I. Miller, L.E. Landree, F.F. Borisy-Rudin, P. Brown, and T. Tihan Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment Am J Physiol Endocrinol Metab 283 2002 E867 E879
10. S. Obici, Z. Feng, A. Arduini, R. Conti, and L. Rossetti Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production Nat Med 9 2003 756 761
11. E.K. Kim, I. Miller, S. Aja, L.E. Landree, M. Pinn, and J. McFadden C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase J Biol Chem 279 2004 19970 19976
12. S.H. Cha, Z. Hu, and M.D. Lane Long-term effects of a fatty acid synthase inhibitor on obese mice: food intake, hypothalamic neuropeptides, and UCP3 Biochem Biophys Res Commun 317 2004 301 308
13. T.M. Loftus, D.E. Jaworsky, G.L. Frehywot, C.A. Townsend, G.V. Ronnett, and M.D. Lane Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors Science 288 2000 2379 2381
14. M.V. Kumar, T. Shimokawa, T.R. Nagy, and M.D. Lane Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice Proc Natl Acad Sci 99 2002 1921 1925
15. T. Shimokawa, M.V. Kumar, and M.D. Lane Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides Proc Natl Acad Sci U S A 99 2002 66 71
16. D.J. Clegg, M.D. Wortman, S.C. Benoit, C.C. McOsker, and R.J. Seeley Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion Diabetes 51 2002 3196 3201
17. S. Obici, Z. Feng, K. Morgan, D. Stein, G. Karkanias, and L. Rossetti Central administration of oleic acid inhibits glucose production and food intake Diabetes 51 2002 271 275
18. J.N. Thupari, E.K. Kim, T.H. Moran, G.V. Ronnett, and F.P. Kuhajda Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass Am J Physiol Endocrinol Metab 287 2004 E97 E104
19. A. Alberts, and M.D. Greenspan Fatty acid metabolism and its regulation 1984 Elsevier Amsterdam
20. S. Wakil Fatty acid synthase, a proficient multifunctional enzyme Biochemistry 28 1989 4523 4530
21. N.B. Beaty, and M.D. Lane Kinetics of activation of acetyl-CoA carboxylase by citrate. Relationship to the rate of polymerization of the enzyme J Biol Chem 258 1983 13043 13050
22. S.A. McCune, and R.A. Harris Mechanism responsible for 5-(tetradecyloxy)-2-furoic acid inhibition of hepatic lipogenesis J Biol Chem 254 1979 10095 10101
23. T. Kusakabe, M. Maeda, N. Hoshi, T. Sugino, K. Watanabe, and T. Fukuda Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells J Histochem Cytochem 48 2000 613 622
24. J. Kim, P. Sarraf, M. Wright, K.M. Yao, E. Mueller, and G. Solanes Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1 J Clin Invest 101 1 1998 1 9
25. J.D. McGarry, S.E. Mills, C.S. Long, and D.W. Foster Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues Biochem J 214 1983 21 28
26. J.D. McGarry, and N.F. Brown The mitochondrial carnitine palmitoyltransferase system from concept to molecular analysis Eur J Biochem 244 1997 1 14
27. S. Eaton, K. Bartlett, and P.A. Quant Carnitine palmitoyltransferase I and the control of beta-oxidation in heart mitochondria Biochem Biophys Res Commun 285 2001 537 539
28. F. Frazer, C.G. Corstorphine, and V.A. Zammit Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane J Biochem 323 1997 711 718
29. V.A. Zammit The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function Biochem J 343 Pt 3 1999 505 515
30. V.A. Zammit, N.T. Price, F. Frazer, and V.N. Jackson Structure-function relationships of the liver and muscle isoforms of carnitine palmitoyltransferase I Biochem Soc 29 2001 287 292
31. F.P. Kuhajda, K. Jenner, F.D. Wood, R.A. Hennigar, L.B. Jacobs, and J.D. Dick Fatty acid synthesis: a potential selective target for antineoplastic therapy Proc Natl Acad Sci U S A 91 1994 6379 6383
32. E.W. Gabrielson, M.L. Pinn, J.R. Testa, and F.P. Kuhajda Increased fatty acid synthase is a therapeutic target in mesothelioma Clin Cancer Res 7 2001 153 157
33. F.P. Kuhajda, E.S. Pizer, J.N. Li, N.S. Mani, G.L. Frehywot, and C.A. Townsend Synthesis and anti-tumor activity an inhibitor of fatty acid synthase Proc Natl Acad USA 97 2000 3450 3454
34. F.P. Kuhajda Fatty acid synthase and human cancer: new perspectives on its role in tumor biology Nutrition 16 2000 202 208
35. H. Funabashi, A. Kawaguchi, H. Tomoda, S. Omura, S. Okuda, and S. Iwasaki Binding site of cerulenin in fatty acid synthetase J Biochem (Tokyo) 105 1989 751 755
36. S. Omura The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis Bacteriol Rev 40 1976 681 697
37. T. Loftus, D. Jaworsky, G. Frehywot, C.A. Townsend, G.V. Ronnett, and M.D. Lane Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors Science 288 2000 2379 2381
38. H. Makimura, T.M. Mizuno, X.J. Yang, J. Silverstein, J. Beasley, and C.V. Mobbs Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting Diabetes 50 2001 733 739
39. H. Makimura, T. Mizuno, X.-J. Yang, J. Silverstein, J. Beasley, and C. Mobbs Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting Diabetes 50 2001 733 739
40. Y.J. Jin, S.Z. Li, Z.S. Zhao, J.J. An, R.Y. Kim, and Y.M. Kim Carnitine palmitoyltransferase-1 (CPT-1) activity stimulation by cerulenin via sympathetic nervous system activation overrides cerulenin's peripheral effect Endocrinology 145 2004 3197 3204
41. J.T. Deeney, J. Gromada, M. Hoy, H.L. Olsen, C.J. Rhodes, and M. Prentki Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells) J Biol Chem 275 2000 9363 9368
42. F.P. Kuhajda, E.S. Pizer, J.N. Li, N.S. Mani, G.L. Frehywot, and C.A. Townsend Synthesis and antitumor activity of an inhibitor of fatty acid synthase Proc Natl Acad Sci U S A 97 2000 3450 3454
43. C.V. Mobbs, and H. Makimura Block the FAS, lose the fat Nat Med 8 2002 335 336
44. S. Gao, and M.D. Lane Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem Proc Natl Acad Sci U S A 100 2003 5628 5633
45. M.D. Wortman, D.J. Clegg, D. D'Alessio, S.C. Woods, and R.J. Seeley C75 inhibits food intake by increasing CNS glucose metabolism Nat Med 9 2003 483 485
46. F.P. Kuhajda, E.P. Pizer, J.L. Li, N.S. Mani, G.L. Frehywot, and C.A. Townsend Synthesis and anti-tumor activity of a novel inhibitor of fatty acid synthase Proc Natl Acad Sci U S A 97 2000 3450 3454
47. Y. Tu, J.N. Thupari, E.K. Kim, M.L. Pinn, T.H. Moran, and G.V. Ronnett C75 alters central and peripheral gene expression to reduce food intake and increase energy expenditure Endocrinology 146 2005 486 493
48. S.C. Woods, M.W. Schwartz, D.G. Baskin, and R.J. Seeley Food intake and the regulation of body weight Annu Rev Psychol 51 2000 255 277
49. I. Miller, G.V. Ronnett, T.H. Moran, and S. Aja Anorexigenic C75 alters c-Fos in mouse hypothalamic and hindbrain subnuclei Neuroreport 15 2004 925 929
50. I.W. Shu, D.L. Lindenberg, T.M. Mizuno, J.L. Roberts, and C.V. Mobbs The fatty acid synthase inhibitor cerulenin and feeding, like leptin, activate hypothalamic pro-opiomelanocortin (POMC) neurons Brain Res 985 2003 1 12
51. K.A. Takahashi, J.L. Smart, H. Liu, and R.D. Cone The anorexigenic fatty acid synthase inhibitor, C75, is a nonspecific neuronal activator Endocrinology 145 2004 184 193
52. Z. Hu, S.H. Cha, S. Chohnan, and M.D. Lane Hypothalamic malonyl-CoA as a mediator of feeding behavior Proc Natl Acad Sci U S A 100 2003 12624 12629
53. S. Eaton, K. Bartlett, and P.A. Quant Carnitine palmitoyltransferase I and the control of B-oxidation in heart mitochondria Biochem Biophys Res Commun 285 2001 537 539
54. D.L. Halvorson, and S.A. McCune Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid Lipids 19 1984 851 856
55. J.N. Thupari, L.E. Landree, G.V. Ronnett, and F.P. Kuhajda C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity Proc Natl Acad Sci 99 2002 9498 9502
56. L.E. Landree, A.L. Hanlon, D.W. Strong, G. Rumbaugh, I.M. Miller, and J.N. Thupari C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism J Biol Chem 279 2004 3817 3827
57. T.C. Kiorpes, D. Hoerr, W. Ho, L.E. Weaner, M.G. Inman, and G.F. Tutwiler Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidyl (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat liver mitochondria J Biol Chem 259 1984 9750 9755
58. N. Yang, J.S. Kays, T.R. Skillman, L. Burris, T.W. Seng, and C. Hammond C75 activates carnitine palmitoyltransferase-1 in isolated mitochondria and intact cells without displacement of bound malonyl CoA J Pharmacol Exp Ther 312 2005 127 133
59. C. Nicot, L. Napal, J. Relat, S. Gonzalez, A. Llebaria, and G. Woldegiorgis C75 activates malonyl-CoA sensitive and insensitive components of the CPT system Biochem Biophys Res Commun 325 2004 660 664
60. G.A. Bray Afferent signals regulating food intake Proc Nutr Soc 59 2000 373 384
61. C.C. Horn, H. Ji, and M.I. Friedman Etomoxir, a fatty acid oxidation inhibitor, increases food intake and reduces hepatic energy status in rats Physiol Behav 81 2004 157 162
62. C.C. Horn, M.G. Tordoff, and M.I. Friedman Role of vagal afferent innervation in feeding and brain Fos expression produced by metabolic inhibitors Brain Res 919 2001 198 206
63. J.E. Koch, H. Ji, M.D. Osbakken, and M.I. Friedman Temporal relationships between eating behavior and liver adenine nucleotides in rats treated with 2,5-AM Am J Physiol 274 1998 R610 R617
64. S. Ritter, and B. Hutton Mercaptoacetate-induced feeding is impaired by central nucleus of the amygdala lesions Physiol Behav 58 1995 1215 1220
65. E. Scharrer Control of food intake by fatty acid oxidation and ketogenesis Nutrition 15 1999 704 714
66. E. Scharrer, T.A. Lutz, and R. Rossi Coding of metabolic information by hepatic sensors controlling food intake T. Shimazu Liver innervation 1996 Libbey London 381 388
67. J.L. Beverly, and R.J. Martin Influence of fatty acid oxidation in lateral hypothalamus on food intake and body composition Am J Physiol 261 1991 R339 R343
68. M.S. Kim, J.Y. Park, C. Namkoong, P.G. Jang, J.W. Ryu, and H.S. Song Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase Nat Med 10 2004 727 733
69. A. Scheurink, and S. Ritter Sympathoadrenal responses to glucoprivation and lipoprivation in rats Physiol Behav 53 1993 995 1000
70. F.H. Koegler, and S. Ritter Galanin injection into the nucleus of the solitary tract stimulates feeding in rats with lesions of the paraventricular nucleus of the hypothalamus Physiol Behav 63 1998 521 527
71. F.H. Koegler, and S. Ritter Aqueduct occlusion does not impair feeding induced by either third or fourth ventricle galanin injection Obes Res 5 1997 262 267
72. F.H. Koegler, and S. Ritter Feeding induced by pharmacological blockade of fatty acid metabolism is selectively attenuated by hindbrain injections of the galanin receptor antagonist, M40 Obes Res 4 1996 329 336
73. G. van Dijk, A. Scheurink, S. Ritter, and A. Steffens Glucose homeostasis and sympathoadrenal activity in mercaptoacetate-treated rats Physiol Behav 57 1995 759 764
74. S. Ritter, and J.S. Taylor Vagal sensory neurons are required for lipoprivic but not glucoprivic feeding in rats Am J Physiol 258 1990 R1395 R1401
75. D.G. Hardie, D. Carling, and N. Halford Roles of the Snf1/Rkin1/AMP- activated protein kinase family in the response to environmental and nutritional stress Semin Cell Biol 5 1994 409 416
76. D.G. Hardie, and D. Carling The AMP-activated protein kinase-fuel gauge of the mammalian cell? Eur J Biochem 246 1997 259 273
77. W.W. Winder, and D.G. Hardie AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes Am J Physiol 277 1999 E1 E10
78. D.G. Hardie, and S.A. Hawley AMP-activated protein kinase: the energy charge hypothesis revisited Bioessays 23 2001 1112 1119
79. S.A. Hawley, M. Davison, A. Woods, S.P. Davies, R.K. Beri, and D. Carling Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase J Biol Chem 271 1996 27879 27887
80. M. Ponticos, Q.L. Lu, J.E. Morgan, D.G. Hardie, T.A. Partridge, and D. Carling Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle EMBO J 17 1998 1688 1699
81. W.W. Winder Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle J Appl Physiol 91 2001 1017 1028
82. B.E. Kemp, K.I. Mitchelhill, D. Stapleton, B.J. Michell, Z.P. Chen, and L.A. Witters Dealing with energy demand: the AMP-activated protein kinase Trends Biochem Sci 24 1999 22 25
83. A.M. Turnley, D. Stapleton, R.J. Mann, L.A. Witters, B.E. Kemp, and P.F. Bartlett Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system J Neurochem 72 1999 1707 1716
84. C. Culmsee, J. Monnig, B.E. Kemp, and M.P. Mattson AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation J Mol Neurosci 17 2001 45 58
85. S.P. Davies, N.R. Helps, P.T. Cohen, and D.G. Hardie 5′-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC FEBS Lett 377 1995 421 425
86. M. Frederich, and J.A. Balschi The relationship between AMP-activated protein kinase activity and AMP concentration in the isolated perfused rat heart J Biol Chem 277 2002 1928 1932
87. P.R. Clarke, and D.G. Hardie Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver Embo J 9 1990 2439 2446
88. D.G. Hardie, D. Carling, and M. Carlson The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67 1998 821 855
89. B. Viollet, F. Andreelli, S.B. Jorgensen, C. Perrin, A. Geloen, and D. Flamez The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity J Clin Invest 111 2003 91 98
90. U. Andersson, K. Filipsson, C.R. Abbott, A. Woods, K. Smith, and S.R. Bloom AMP-activated protein kinase plays a role in the control of food intake J Biol Chem 279 2004 12005 12008
91. Y. Minokoshi, T. Alquier, N. Furukawa, Y.B. Kim, A. Lee, and B. Xue AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus Nature 428 2004 569 574
92. R.L. Sabina, D. Patterson, and E.W. Holmes 5-Amino-4-imidazolecarboxamide riboside (Z-riboside) metabolism in eukaryotic cells J Biol Chem 260 1985 6107 6114
93. J.E. Sullivan, K.J. Brocklehurst, A.E. Marley, F. Carey, D. Carling, and R.K. Beri Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase FEBS Lett 353 1994 33 36
94. Y. Minokoshi, Y.-B. Kim, O. Peroni, L.G. Fryer, C. Muller, and D. Carling Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase Nature 415 2002 339 343
95. A.B. Sprenkle, S.P. Davies, D. Carling, D.G. Hardie, and T.W. Sturgill Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase FEBS Lett 403 1997 254 258
96. H.T. Bergen, T. Mizuno, J. Taylor, and C.V. Mobbs Resistance to diet-induced obesity is associated with increased proopiomelanocortin mRNA and decreased neuropeptide Y mRNA in the hypothalamus Brain Res 851 1999 198 203
97. B.E. Levin, and A.A. Dunn-Meynell Sibutramine alters the central mechanisms regulating the defended body weight in diet-induced obese rats Am J Physiol Regul Integr Comp Physiol 279 2000 R2222 R2228
98. M. Ziotopoulou, C.S. Mantzoros, S.M. Hileman, and J.S. Flier Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice Am J Physiol Endocrinol Metab 279 2000 E838 E845
99. H. Wang, L.H. Storlien, and X.F. Huang Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression Am J Physiol Endocrinol Metab 282 2002 E1352 E1359
100. F. Rohner-Jeanrenaud, L.S. Craft, J. Bridwell, T.M. Suter, F.C. Tinsley, and D.L. Smiley Chronic central infusion of cocaine- and amphetamine-regulated transcript (CART 55-102): effects on body weight homeostasis in lean and high-fat-fed obese rats Int J Obes Relat Metab Disord 26 2002 143 149
101. L.K. Dircks, and H.S. Sul Mammalian mitochondrial glycerol-3-phosphate acyltransferase Biochim Biophys Acta 1348 1997 17 26
102. K.S. Echtay, D. Roussel, J. St-Pierre, M.B. Jekabsons, S. Cadenas, and J.A. Stuart Superoxide activates mitochondrial uncoupling proteins Nature 415 2002 96 99
103. J. Berger, and D.E. Moller The mechanisms of action of PPARs Annu Rev Med 53 2002 409 435
104. B.N. Finck, J.J. Lehman, T.C. Leone, M.J. Welch, M.J. Bennett, and A. Kovacs The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus J Clin Invest 109 2002 121 130