메뉴 건너뛰기




Volumn 50, Issue 2, 2011, Pages 81-88

Dietary naringenin increases hepatic peroxisome proliferators-activated receptor α protein expression and decreases plasma triglyceride and adiposity in rats

Author keywords

Anti adiposity; CPT 1; Hypolipidemic effect; In vivo; Naringenin; PPAR ; UCP2

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE I; CHOLESTEROL; CORN OIL; FATTY ACID; LARD; METHIONINE; MINERAL; NARINGENIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SODIUM SELENITE; SUCROSE; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 2; VITAMIN; ANTILIPEMIC AGENT; CARNITINE PALMITOYLTRANSFERASE; FLAVANONE DERIVATIVE; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; TRANSCRIPTION FACTOR;

EID: 79958276860     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-010-0117-8     Document Type: Article
Times cited : (134)

References (48)
  • 2
    • 33645453199 scopus 로고    scopus 로고
    • Red grapefruit positively influences serum triglyceride level in patients suffering from coronary atherosclerosis: Studies in vitro and in humans
    • Gorinstein S, Caspi A, Libman I et al (2006) Red grapefruit positively influences serum triglyceride level in patients suffering from coronary atherosclerosis: studies in vitro and in humans. J Agric Food Chem 54:1887-1892
    • (2006) J Agric Food Chem , vol.54 , pp. 1887-1892
    • Gorinstein, S.1    Caspi, A.2    Libman, I.3
  • 3
    • 0033736595 scopus 로고    scopus 로고
    • HDL-cholesterol- raising effect of orange juice in subjects with hypercholesterolemia
    • Kurowska EM, Spence JD, Jordan J et al (2000) HDL-cholesterol- raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 72:1095-1100
    • (2000) Am J Clin Nutr , vol.72 , pp. 1095-1100
    • Kurowska, E.M.1    Spence, J.D.2    Jordan, J.3
  • 4
    • 10044246299 scopus 로고    scopus 로고
    • Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology
    • Erlund I (2004) Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology. Nutr Res 24:851-874
    • (2004) Nutr Res , vol.24 , pp. 851-874
    • Erlund, I.1
  • 5
    • 0034237342 scopus 로고    scopus 로고
    • Effects of naringin and lovastatin on plasma and hepatic lipids in high- fat and high-cholesterol fed rats
    • DOI 10.1016/S0271-5317(00)00191-3, PII S0271531700001913
    • Bok SH, Shin YW, Bae KH et al (2000) Effects of naringin and lovastatin on plasma and hepatic lipids in high-fat and high-cholesterol fed rats. Nutr Res 20:1007-1015 (Pubitemid 30407942)
    • (2000) Nutrition Research , vol.20 , Issue.7 , pp. 1007-1015
    • Bok, S.-H.1    Shin, Y.W.2    Bae, K.-H.3    Jeong, T.-S.4    Kwon, Y.-K.5    Park, Y.B.6    Choi, M.-S.7
  • 6
    • 0035741860 scopus 로고    scopus 로고
    • Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E
    • Choi MS, Do KM, Park YS et al (2001) Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E. Ann Nutr Metab 45:193-201
    • (2001) Ann Nutr Metab , vol.45 , pp. 193-201
    • Choi, M.S.1    Do, K.M.2    Park, Y.S.3
  • 7
    • 0032725927 scopus 로고    scopus 로고
    • Cholesterol-lowering activity of naringenin via inhibition of 8-hydroxy-3-methylglutaryl coenzyme a reductase and acyl coenzyme A:Cholesterol acyltransferase in rats
    • DOI 10.1159/000012783
    • Lee SH, Park YB, Bae KH et al (1999) Cholesterol-Lowering Activity of Naringenin via Inhibition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Acyl Coenzyme A: Cholesterol Acyltransferase in Rats. Ann Nutr Metab 43:173-180 (Pubitemid 29494862)
    • (1999) Annals of Nutrition and Metabolism , vol.43 , Issue.3 , pp. 173-180
    • Lee, S.H.1    Park, Y.B.2    Bae, K.H.3    Bok, S.H.4    Kwon, Y.K.5    Lee, E.S.6    Choi, M.S.7
  • 8
    • 0032786872 scopus 로고    scopus 로고
    • Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations
    • Santos KFR, Oliveira TT, Nagem TJ et al (1999) Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations. Pharmacol Res 40:493-496
    • (1999) Pharmacol Res , vol.40 , pp. 493-496
    • Santos, K.F.R.1    Oliveira, T.T.2    Nagem, T.J.3
  • 9
    • 0034813893 scopus 로고    scopus 로고
    • Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol- fed rabbits
    • Lee CH, Jeong TS, Choi YK et al (2001) Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol- fed rabbits. Biochem Bioph Res Co 284:681-688
    • (2001) Biochem Bioph Res Co , vol.284 , pp. 681-688
    • Lee, C.H.1    Jeong, T.S.2    Choi, Y.K.3
  • 10
    • 33645985463 scopus 로고    scopus 로고
    • Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids
    • Huong DTT, Takahashi Y, Ide T (2006) Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids. Nutrition 22:546-552
    • (2006) Nutrition , vol.22 , pp. 546-552
    • Huong, D.T.T.1    Takahashi, Y.2    Ide, T.3
  • 11
    • 0037432066 scopus 로고    scopus 로고
    • Hepatocyte ApoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation
    • DOI 10.1021/bi026731o
    • Borradaile NM, de Dreu LE, Barrett PH, Behrsin CD, Huff MW (2003) Hepatocyte ApoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation. Biochemistry 42:1283-1291 (Pubitemid 36184069)
    • (2003) Biochemistry , vol.42 , Issue.5 , pp. 1283-1291
    • Borradaile, N.M.1    De Dreu, L.E.2    Barrett, P.H.R.3    Behrsin, C.D.4    Huff, M.W.5
  • 12
    • 0141643289 scopus 로고    scopus 로고
    • Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation
    • DOI 10.2337/diabetes.52.10.2554
    • Borradaile NM, de Dreu LE, Huff MW (2003) Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation. Diabetes 52:2554-2561 (Pubitemid 37210545)
    • (2003) Diabetes , vol.52 , Issue.10 , pp. 2554-2561
    • Borradaile, N.M.1    De Dreu, L.E.2    Huff, M.W.3
  • 13
    • 0034989204 scopus 로고    scopus 로고
    • Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP
    • Wilcox LJ, Borradaile NM, de Dreu LE, Huff MW (2001) Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res 42:725-734 (Pubitemid 32507172)
    • (2001) Journal of Lipid Research , vol.42 , Issue.5 , pp. 725-734
    • Wilcox, L.J.1    Borradaile, N.M.2    De Dreu, L.E.3    Huff, M.W.4
  • 14
    • 20044368479 scopus 로고    scopus 로고
    • Inhibition of microsomal triglyceride transfer protein expression and apolipoprotein B100 secretion by the citrus flavonoid naringenin and by insulin involves activation of the mitogen-activated protein kinase pathway in hepatocytes
    • DOI 10.2337/diabetes.54.6.1676
    • Allister EM, Borradaile NM, Edwards JY, Huff MW (2005) Inhibition of microsomal triglyceride transfer protein expression and apolipoprotein B100 secretion by the citrus flavonoid naringenin and by insulin involves activation of the mitogen-activated protein kinase pathway in hepatocytes. Diabetes 54:1676-1683 (Pubitemid 40770757)
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1676-1683
    • Allister, E.M.1    Borradaile, N.M.2    Edwards, J.Y.3    Huff, M.W.4
  • 17
    • 0025923629 scopus 로고
    • Effect of the peroxisome proliferator LY171883 on triglyceride accumulation in rats fed a fatfree diet
    • Foxworthy PS, Eacho PI (1991) Effect of the peroxisome proliferator LY171883 on triglyceride accumulation in rats fed a fatfree diet. Biochem Pharmacol 42:1487-1491
    • (1991) Biochem Pharmacol , vol.42 , pp. 1487-1491
    • Foxworthy, P.S.1    Eacho, P.I.2
  • 19
    • 18644365060 scopus 로고    scopus 로고
    • Fenofibrate lowers abdominal and skeletal adiposity and improves insulin sensitivity in OLETF rats
    • Lee HJ, Choi SS, Park MK, An YJ et al (2002) Fenofibrate lowers abdominal and skeletal adiposity and improves insulin sensitivity in OLETF rats. Biochem Bioph Res Co 296:293-299
    • (2002) Biochem Bioph Res Co , vol.296 , pp. 293-299
    • Lee, H.J.1    Choi, S.S.2    Park, M.K.3    An, Y.J.4
  • 20
    • 2942529395 scopus 로고    scopus 로고
    • Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARa
    • DOI 10.1016/j.mce.2004.03.011, PII S0303720704001832
    • Kim S, Shin HJ, Kim SY, Kim JH et al (2004) Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARa. Mol Cell Endocrinol 220:51-58 (Pubitemid 38757880)
    • (2004) Molecular and Cellular Endocrinology , vol.220 , Issue.1-2 , pp. 51-58
    • Kim, S.1    Shin, H.-J.2    Kim, S.Y.3    Kim, J.H.4    Lee, Y.S.5    Kim, D.-H.6    Lee, M.-O.7
  • 21
    • 0036866660 scopus 로고    scopus 로고
    • Beneficial effects of tea catechins on diet-induced obesity: Stimulation of lipid catabolism in the liver
    • DOI 10.1038/sj.ijo.0802141
    • Murase T, Nagasawa A, Suzuki J, Hase T, Tokimitsu I (2002) Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver. Int J Obes Relat Metab Disord 26:1459-1464 (Pubitemid 36005776)
    • (2002) International Journal of Obesity , vol.26 , Issue.11 , pp. 1459-1464
    • Murase, T.1    Nagasawa, A.2    Suzuki, J.3    Hase, T.4    Tokimitsu, I.5
  • 22
    • 55449121190 scopus 로고    scopus 로고
    • Naringenin and hesperetin, two flavonoids derived from Citrus aurantium upregulate transcription of adiponectin
    • Liu Li, Song S, Kun Z, Zhi-Qiang N et al (2008) Naringenin and hesperetin, two flavonoids derived from Citrus aurantium upregulate transcription of adiponectin. Phytother Res 22:1400-1403
    • (2008) Phytother Res , vol.22 , pp. 1400-1403
    • Li, U.1    Song, S.2    Kun, Z.3    Zhi-Qiang, N.4
  • 24
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 25
    • 0034905291 scopus 로고    scopus 로고
    • UCN-01 suppresses E2F-1 mediated by ubiquitin-proteasome-dependent degradation
    • Hsueh CT, Wu YC, Schwartz GK (2001) UCN-01 suppresses E2F-1 mediated by ubiquitin-proteasome-dependent degradation. Clin Cancer Res 7:669-674
    • (2001) Clin Cancer Res , vol.7 , pp. 669-674
    • Hsueh, C.T.1    Wu, Y.C.2    Schwartz, G.K.3
  • 26
    • 3042799325 scopus 로고    scopus 로고
    • An internal control for immunoblot analysis using the blotted membrane
    • DOI 10.1016/j.ab.2004.04.024, PII S0003269704003641
    • Song J, Lu Y, Pang S, Chiu R (2004) An internal control for immunoblot analysis using the blotted membrane. Anal Biochem 331:201-203 (Pubitemid 38881578)
    • (2004) Analytical Biochemistry , vol.331 , Issue.1 , pp. 201-203
    • Song, J.1    Lu, Y.2    Pang, S.3    Chiu, R.4
  • 27
    • 0024356395 scopus 로고
    • Co-ordinate induction of hepatic mitochondrial and peroxisomal carnitine acyltransferase synthesis by diet and drugs
    • Brady PS, Marine KA, Brady LJ, Ramsay RR (1989) Co-ordinate induction of hepatic mitochondrial and peroxisomal carnitine acyltransferase synthesis by diet and drugs. Biochem J 260:93-100 (Pubitemid 19139902)
    • (1989) Biochemical Journal , vol.260 , Issue.1 , pp. 93-100
    • Brady, P.S.1    Marine, K.A.2    Brady, L.J.3    Ramsay, R.R.4
  • 29
    • 0032502704 scopus 로고    scopus 로고
    • Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor
    • DOI 10.1074/jbc.273.15.8560
    • Mascaro C, Acosta E, Ortiz JA, Marrero PF et al (1998) Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. J Biol Chem 273:8560-8563 (Pubitemid 28176129)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.15 , pp. 8560-8563
    • Mascaro, C.1    Acosta, E.2    Ortiz, J.A.3    Marrero, P.F.4    Hegardt, F.G.5    Haro, D.6
  • 31
    • 0032844429 scopus 로고    scopus 로고
    • Antiatherogenic properties of naringenin, a citrus flavonoid
    • Wilcox LJ, Borradaile NM, Huff MW (1999) Antiatherogenic properties of naringenin, a citrus flavonoid. Cardiovasc Drug Rev 17:160-178 (Pubitemid 29485363)
    • (1999) Cardiovascular Drug Reviews , vol.17 , Issue.2 , pp. 160-178
    • Wilcox, L.J.1    Borradaile, N.M.2    Huff, M.W.3
  • 32
    • 4644233222 scopus 로고    scopus 로고
    • Hepatolipidemic effects of naringenin in high cornstarch-versus high coconut oil-fed rats
    • Wood N (2004) Hepatolipidemic effects of naringenin in high cornstarch-versus high coconut oil-fed rats. J Med Food 7:315-319
    • (2004) J Med Food , vol.7 , pp. 315-319
    • Wood, N.1
  • 34
    • 0037294718 scopus 로고    scopus 로고
    • Naringenin 7-O-cetyl ether as inhibitor of HMG-CoA reductase and modulator of plasma and hepatic lipids in high cholesterol-fed rats
    • Lee MK, Moon SS, Lee SE et al (2003) Naringenin 7-O-cetyl ether as inhibitor of HMG-CoA reductase and modulator of plasma and hepatic lipids in high cholesterol-fed rats. Bioorgan Med Chem 11:393-398
    • (2003) Bioorgan Med Chem , vol.11 , pp. 393-398
    • Lee, M.K.1    Moon, S.S.2    Lee, S.E.3
  • 35
    • 0002978852 scopus 로고
    • Differentiation of citrus juices by factorial discriminant analysis using liquid chromatography of flavanone glycosides
    • Mouly PP, Arzouyan CR, Gaydou EM, Estienne JM (1994) Differentiation of citrus juices by factorial discriminant analysis using liquid chromatography of flavanone glycosides. J Agr Food Chem 42:70-79
    • (1994) J Agr Food Chem , vol.42 , pp. 70-79
    • Mouly, P.P.1    Arzouyan, C.R.2    Gaydou, E.M.3    Estienne, J.M.4
  • 36
    • 0026540899 scopus 로고
    • Mechanisms of triglyceride-lowering effect of an HMG-CoA reductase inhibitor in a hypertriglyceridemic animal model, the Zucker obese rat
    • Kasim SE, LeBoeuf RC, Khilnani S, Tallapaka L et al (1992) Mechanisms of triglyceride-lowering effect of an HMG-CoA reductase inhibitor in a hypertriglyceridemic animal model, the Zucker obese rat. J Lipid Res 33:1-7
    • (1992) J Lipid Res , vol.33 , pp. 1-7
    • Kasim, S.E.1    LeBoeuf, R.C.2    Khilnani, S.3    Tallapaka, L.4
  • 38
    • 0034668205 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis
    • Neve BP, Fruchart JC, Staels B (2000) Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis. Biochem Pharmacol 60:1245-1250
    • (2000) Biochem Pharmacol , vol.60 , pp. 1245-1250
    • Neve, B.P.1    Fruchart, J.C.2    Staels, B.3
  • 39
    • 0035078484 scopus 로고    scopus 로고
    • Etiopathogenesis of Nonalcoholic Steatohepatitis
    • Chitturi S, Farrell GC (2001) Etiopathogenesis of Nonalcoholic Steatohepatitis. Semin Liver Dis 21:027-042
    • (2001) Semin Liver Dis , vol.21 , pp. 027-042
    • Chitturi, S.1    Farrell, G.C.2
  • 41
    • 0033774715 scopus 로고    scopus 로고
    • Implications of peroxisome proliferator-activated receptors (PPARs) in development cell life status and disease
    • Keller J, Collet P, Bianchi A, Huin C et al (2000) Implications of peroxisome proliferator-activated receptors (PPARs) in development cell life status and disease. Int J Dev Biol 44:429-442
    • (2000) Int J Dev Biol , vol.44 , pp. 429-442
    • Keller, J.1    Collet, P.2    Bianchi, A.3    Huin, C.4
  • 42
    • 70349651441 scopus 로고    scopus 로고
    • Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance
    • Mulvihill EE, Allister EM, Sutherland BG, Telford DE et al (2009) Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes 58:2198-2210
    • (2009) Diabetes , vol.58 , pp. 2198-2210
    • Mulvihill, E.E.1    Allister, E.M.2    Sutherland, B.G.3    Telford, D.E.4
  • 43
    • 11844264895 scopus 로고    scopus 로고
    • Hepatic gene expression profiles are altered by genistein supplementation in mice with diet-induced obesity
    • Kim S, Sohn I, Lee YS, Lee YS (2005) Hepatic gene expression profiles are altered by genistein supplementation in mice with diet-induced obesity. J Nutr 135:33-41 (Pubitemid 40094317)
    • (2005) Journal of Nutrition , vol.135 , Issue.1 , pp. 33-41
    • Kim, S.1    Sohn, I.2    Lee, Y.S.3    Lee, Y.S.4
  • 45
    • 77950866885 scopus 로고    scopus 로고
    • Naringenin enhances insulin-stimulated tyrosine phosphorylation and improves the cellular actions of insulin in a dietary model of metabolic syndrome
    • doi: 10.1007/s00394-009-0054-6
    • Kannappan S, Anuradha CV (2009) Naringenin enhances insulin-stimulated tyrosine phosphorylation and improves the cellular actions of insulin in a dietary model of metabolic syndrome. Eur J Nutr. doi: 10.1007/s00394-009-0054-6
    • (2009) Eur J Nutr
    • Kannappan, S.1    Anuradha, C.V.2
  • 47
    • 57849153018 scopus 로고    scopus 로고
    • Naringenin and hesperetin induce growth arrest, apoptosis, and cytoplasmic fat deposit in human preadipocytes
    • Morikawa K, Nonaka M, Mochizuki H, Handa K et al (2008) Naringenin and hesperetin induce growth arrest, apoptosis, and cytoplasmic fat deposit in human preadipocytes. J Agric Food Chem 56:11030-11037
    • (2008) J Agric Food Chem , vol.56 , pp. 11030-11037
    • Morikawa, K.1    Nonaka, M.2    Mochizuki, H.3    Handa, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.