메뉴 건너뛰기




Volumn 28, Issue 8, 2011, Pages 1792-1818

Current and future drug targets in weight management

Author keywords

energy metabolism; food intake; obesity complications; satiety hormones; weight management

Indexed keywords

189075; 2,4 DINITROPHENOL; AMFEBUTAMONE; ANTIOBESITY AGENT; BOMBESIN; CANAGLIFLOZIN; CANAGLIFOZIN; CETILISTAT; CHOLECYSTOKININ; DEXFENFLURAMINE; DIACYLGLYCEROL ACYLTRANSFERASE 1; DIRLOTAPIDE; EGR 773; ENZYME INHIBITOR; EPHEDRINE; FENFLURAMINE; GSK 869682; LOMITAPIDE; LORCASERIN; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITOR; NALTREXONE; PF 04620110; PHENTERMINE; PLACEBO; REMOGLIFOZIN ETABONATE; RIMONABANT; SERGLIFOZIN; SIBUTRAMINE; TETRAHYDROLIPSTATIN; TOPIRAMATE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; USISTAPIDE;

EID: 79961165599     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0341-1     Document Type: Review
Times cited : (65)

References (174)
  • 2
    • 40349088822 scopus 로고    scopus 로고
    • The epidemiology of obesity: The size of the problem
    • DOI 10.1111/j.1365-2796.2008.01922.x
    • WPT James 2008 The epidemiology of obesity: the size of the problem J Intern Med 263 336 352 18312311 1:STN:280:DC%2BD1c7msFaltg%3D%3D (Pubitemid 351342683)
    • (2008) Journal of Internal Medicine , vol.263 , Issue.4 , pp. 336-352
    • James, W.P.T.1
  • 3
    • 53849092685 scopus 로고    scopus 로고
    • Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic
    • 18719634
    • Y Wang MA Beydoun L Liang B Caballero SK Kumanyika 2008 Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic Obesity 16 2323 2330 18719634
    • (2008) Obesity , vol.16 , pp. 2323-2330
    • Wang, Y.1    Beydoun, M.A.2    Liang, L.3    Caballero, B.4    Kumanyika, S.K.5
  • 4
    • 33845886915 scopus 로고    scopus 로고
    • Abdominal obesity and metabolic syndrome
    • DOI 10.1038/nature05488, PII NATURE05488
    • J-P Despres I Lemieux 2006 Abdominal obesity and metabolic syndrome Nature 444 881 887 17167477 1:CAS:528:DC%2BD28XhtlShtrzF (Pubitemid 46024995)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 881-887
    • Despres, J.-P.1    Lemieux, I.2
  • 6
    • 25844457693 scopus 로고    scopus 로고
    • Obesity
    • DOI 10.1016/S0140-6736(05)67483-1, PII S0140673605674831
    • DW Haslam WP James 2005 Obesity Lancet 366 1197 1209 16198769 (Pubitemid 41393598)
    • (2005) Lancet , vol.366 , Issue.9492 , pp. 1197-1209
    • Haslam, D.W.1    James, W.P.T.2
  • 8
    • 33646946281 scopus 로고    scopus 로고
    • Visceral fat is an independent predictor of all-cause mortality in men
    • JL Kuk PT Katzmarzyk MZ Nichaman TS Church SN Blair R Ross 2006 Visceral fat is an independent predictor of all-cause mortality in men Obesity 14 336 341 16571861 (Pubitemid 46214766)
    • (2006) Obesity , vol.14 , Issue.2 , pp. 336-341
    • Kuk, J.L.1    Katzmarzyk, P.T.2    Nichaman, M.Z.3    Church, T.S.4    Blair, S.N.5    Ross, R.6
  • 9
    • 33748105168 scopus 로고    scopus 로고
    • The obesity epidemic and its cardiovascular consequences
    • DOI 10.1097/01.hco.0000231406.84554.96, PII 0000157320060700000015
    • A Behn E Ur 2006 The obesity epidemic and its cardiovascular consequences Curr Opin Cardiol 21 353 360 16755205 (Pubitemid 44315069)
    • (2006) Current Opinion in Cardiology , vol.21 , Issue.4 , pp. 353-360
    • Behn, A.1    Ur, E.2
  • 10
    • 33749474088 scopus 로고    scopus 로고
    • ABC of obesity: Assessment of obesity and its clinical implications
    • TS Han N Sattar M Lean 2006 Assessment of obesity and its clinical implications Br Med J 333 695 698 (Pubitemid 44521018)
    • (2006) British Medical Journal , vol.333 , Issue.7570 , pp. 695-698
    • Han, T.S.1    Sattar, N.2    Lean, M.3
  • 11
    • 72049128308 scopus 로고    scopus 로고
    • Fat distribution in men of different waist girth, fitness level and exercise habit
    • G O'Donovan EL Thomas JP McCarthy, et al. 2009 Fat distribution in men of different waist girth, fitness level and exercise habit Int J Obes 33 1356 1362
    • (2009) Int J Obes , vol.33 , pp. 1356-1362
    • O'Donovan, G.1    Thomas, E.L.2    McCarthy, J.P.3
  • 12
    • 77951960109 scopus 로고    scopus 로고
    • Normal weight obesity: A risk factor for cardiometabolic dysregulation and cardiovascular mortality
    • 19933515
    • A Romero-Corral VK Somers J Sierra-Johnson, et al. 2010 Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality Eur Heart J 31 737 746 19933515
    • (2010) Eur Heart J , vol.31 , pp. 737-746
    • Romero-Corral, A.1    Somers, V.K.2    Sierra-Johnson, J.3
  • 13
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • DOI 10.1038/nature05485, PII NATURE05485
    • GS Hotamisligil 2006 Inflammation and metabolic disorders Nature 444 860 867 17167474 1:CAS:528:DC%2BD28XhtlShtrzK (Pubitemid 46024993)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 860-867
    • Hotamisligil, G.S.1
  • 14
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, Inflammation, and Insulin Resistance
    • DOI 10.1053/j.gastro.2007.03.059, PII S0016508507005859
    • SE Shoelson L Herrero A Naaz 2007 Obesity, inflammation, and insulin resistance Gastroenterology 132 2169 2180 17498510 1:CAS:528: DC%2BD2sXmsVyns7w%3D (Pubitemid 46693756)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 15
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • DOI 10.1038/nrm2391, PII NRM2391
    • A Guilherme JV Virbasius V Puri MP Czech 2008 Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes Nat Rev Mol Cell Biol 9 367 377 18401346 1:CAS:528:DC%2BD1cXkvF2gt7k%3D (Pubitemid 351574198)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.5 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 16
    • 40949120497 scopus 로고    scopus 로고
    • From a glucocentric to a lipocentric approach towards metabolic syndrome
    • 18342796 1:CAS:528:DC%2BD1cXjsVSjsbs%3D
    • S Mittra VS Bansal PK Bhatnagar 2008 From a glucocentric to a lipocentric approach towards metabolic syndrome Drug Discov Today 13 211 218 18342796 1:CAS:528:DC%2BD1cXjsVSjsbs%3D
    • (2008) Drug Discov Today , vol.13 , pp. 211-218
    • Mittra, S.1    Bansal, V.S.2    Bhatnagar, P.K.3
  • 17
    • 38949119419 scopus 로고    scopus 로고
    • Salsalate improves glycemia and inflammatory parameters in obese young adults
    • DOI 10.2337/dc07-1338
    • A Fleischman SE Shoelson R Bernier AB Goldfine 2008 Salsalate improves glycemia and inflammatory parameters in obese young adults Diab Care 31 289 294 1:CAS:528:DC%2BD1cXis1ajsr0%3D (Pubitemid 351213338)
    • (2008) Diabetes Care , vol.31 , Issue.2 , pp. 289-294
    • Fleischman, A.1    Shoelson, S.E.2    Bernier, R.3    Goldfine, A.B.4
  • 18
    • 56749164791 scopus 로고    scopus 로고
    • Nutrient sensing and inflammation in metabolic diseases
    • 19029988 1:CAS:528:DC%2BD1cXhsVWlsb7N
    • GS Hotamisligil E Erbay 2008 Nutrient sensing and inflammation in metabolic diseases Nat Rev Immunol 8 923 934 19029988 1:CAS:528: DC%2BD1cXhsVWlsb7N
    • (2008) Nat Rev Immunol , vol.8 , pp. 923-934
    • Hotamisligil, G.S.1    Erbay, E.2
  • 19
    • 64149101055 scopus 로고    scopus 로고
    • Getting away from glucose: Fanning the flames of obesity-induced inflammation
    • 19350009 1:CAS:528:DC%2BD1MXktVKgsb0%3D
    • SE Shoelson AB Goldfine 2009 Getting away from glucose: fanning the flames of obesity-induced inflammation Nat Med 15 373 374 19350009 1:CAS:528:DC%2BD1MXktVKgsb0%3D
    • (2009) Nat Med , vol.15 , pp. 373-374
    • Shoelson, S.E.1    Goldfine, A.B.2
  • 20
    • 68749100675 scopus 로고    scopus 로고
    • Sexual dimorphism in body fat distribution and risk for cardiovascular diseases
    • 20560019
    • TP Nedungadi DJ Clegg 2009 Sexual dimorphism in body fat distribution and risk for cardiovascular diseases J Cardiovasc Transl Res 2 321 327 20560019
    • (2009) J Cardiovasc Transl Res , vol.2 , pp. 321-327
    • Nedungadi, T.P.1    Clegg, D.J.2
  • 21
    • 0024507782 scopus 로고
    • Metabolism of adipose tissue in intraabdominal depots of nonobese men and women
    • DOI 10.1016/0026-0495(89)90198-4
    • M Rebuffe-Scrive B Andersson L Olbe P Bjorntorp 1989 Metabolism of adipose tissue in intraabdominal depots of nonobese men and women Metabolism 38 453 458 2725284 1:CAS:528:DyaL1MXhslSks7k%3D (Pubitemid 19125880)
    • (1989) Metabolism: Clinical and Experimental , vol.38 , Issue.5 , pp. 453-458
    • Rebuffe-Scrive, M.1    Andersson, B.2    Olbe, L.3    Bjorntorp, P.4
  • 22
    • 77951666931 scopus 로고    scopus 로고
    • Pioglitazone increases the proportion of small cells in human abdominal subcutaneous adipose tissue
    • 19910937 1:CAS:528:DC%2BC3cXlt1ahsbc%3D
    • TM McLaughlin T Liu G Yee, et al. 2010 Pioglitazone increases the proportion of small cells in human abdominal subcutaneous adipose tissue Obesity 18 926 931 19910937 1:CAS:528:DC%2BC3cXlt1ahsbc%3D
    • (2010) Obesity , vol.18 , pp. 926-931
    • McLaughlin, T.M.1    Liu, T.2    Yee, G.3
  • 23
    • 72449195818 scopus 로고    scopus 로고
    • The utility of physical activity in the management of global cardiometabolic risk
    • Janiszewski PM, Ross R. The utility of physical activity in the management of global cardiometabolic risk. Obesity. 2009;17.
    • (2009) Obesity , pp. 17
    • Janiszewski, P.M.1    Ross, R.2
  • 24
    • 70350072281 scopus 로고    scopus 로고
    • Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss
    • 19637289 1:CAS:528:DC%2BD1MXhtlWlu7nK
    • NA Johnson T Sachinwalla DW Walton, et al. 2009 Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss Hepatology 50 1105 1112 19637289 1:CAS:528:DC%2BD1MXhtlWlu7nK
    • (2009) Hepatology , vol.50 , pp. 1105-1112
    • Johnson, N.A.1    Sachinwalla, T.2    Walton, D.W.3
  • 25
    • 68949090423 scopus 로고    scopus 로고
    • The future of obesity reduction: Beyond weight loss
    • 19421242
    • R Ross AJ Bradshaw 2009 The future of obesity reduction: beyond weight loss Nat Rev Endocrinol 5 319 326 19421242
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 319-326
    • Ross, R.1    Bradshaw, A.J.2
  • 26
    • 54949149122 scopus 로고    scopus 로고
    • The exercise pill - Too good to be true?
    • 18946072 1:CAS:528:DC%2BD1cXht12msr%2FN
    • LJ Goodyear 2008 The exercise pill - too good to be true? N Engl J Med 359 1842 1844 18946072 1:CAS:528:DC%2BD1cXht12msr%2FN
    • (2008) N Engl J Med , vol.359 , pp. 1842-1844
    • Goodyear, L.J.1
  • 27
    • 9144251736 scopus 로고    scopus 로고
    • Exercise in a pill: Feasibility of energy expenditure targets
    • DOI 10.2174/1568007043337076
    • J Himms-Hagen 2004 Exercise in a pill: feasibility of energy expenditure targets Curr Drug Targets CNS Neurol Disord 3 389 409 15544447 1:CAS:528:DC%2BD2cXhtVWitLnN (Pubitemid 39545297)
    • (2004) Current Drug Targets: CNS and Neurological Disorders , vol.3 , Issue.5 , pp. 389-409
    • Himms-Hagen, J.1
  • 28
    • 48449094498 scopus 로고    scopus 로고
    • AMPK and PPARδ agonists are exercise mimetics
    • 18674809 1:CAS:528:DC%2BD1cXhtVSis77P
    • VA Narkar 2008 AMPK and PPARδ agonists are exercise mimetics Cell 134 405 415 18674809 1:CAS:528:DC%2BD1cXhtVSis77P
    • (2008) Cell , vol.134 , pp. 405-415
    • Narkar, V.A.1
  • 31
    • 33745871197 scopus 로고    scopus 로고
    • Eating for pleasure or just wanting to eat? Reconsidering sensory hedonic responses as a driver of obesity
    • DOI 10.1016/j.appet.2006.02.006, PII S0195666306002066
    • DJ Mela 2006 Eating for pleasure or just wanting to eat? Reconsidering sensory hedonic responses as a driver of obesity Appetite 47 10 17 16647788 (Pubitemid 44038034)
    • (2006) Appetite , vol.47 , Issue.1 , pp. 10-17
    • Mela, D.J.1
  • 32
    • 41349090064 scopus 로고    scopus 로고
    • Anti-obesity drugs and neural circuits of feeding
    • 18353447 1:CAS:528:DC%2BD1cXksVehsrk%3D
    • RAH Adan LJMJ Vanderschuren SE la Fleur 2008 Anti-obesity drugs and neural circuits of feeding Trends Pharmacol Sci 29 208 217 18353447 1:CAS:528:DC%2BD1cXksVehsrk%3D
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 208-217
    • Adan, R.A.H.1    Ljmj, V.2    La Fleur, S.E.3
  • 33
    • 33646889517 scopus 로고    scopus 로고
    • Cannabinoids, opioids and eating behavior: The molecular face of hedonism?
    • DOI 10.1016/j.brainresrev.2005.10.004, PII S0165017305001529
    • D Cota MH Tschöp TL Horvath AS Levine 2006 Cannabinoids, opioids and eating behavior: the molecular face of hedonism? Brain Res Rev 51 85 107 16364446 1:CAS:528:DC%2BD28XltFOnur0%3D (Pubitemid 43782532)
    • (2006) Brain Research Reviews , vol.51 , Issue.1 , pp. 85-107
    • Cota, D.1    Tschop, M.H.2    Horvath, T.L.3    Levine, A.S.4
  • 35
    • 42549162394 scopus 로고    scopus 로고
    • Medicine: Bypassing medicine to treat diabetes
    • 18436751 1:CAS:528:DC%2BD1cXltlCls7c%3D
    • J Couzin 2008 Medicine: bypassing medicine to treat diabetes Science 320 438 440 18436751 1:CAS:528:DC%2BD1cXltlCls7c%3D
    • (2008) Science , vol.320 , pp. 438-440
    • Couzin, J.1
  • 36
    • 68949165946 scopus 로고    scopus 로고
    • Appetite suppressants, cardiac valve disease and combination pharmacotherapy
    • 19092640
    • RB Rothman MH Baumann 2009 Appetite suppressants, cardiac valve disease and combination pharmacotherapy Am J Ther 16 354 364 19092640
    • (2009) Am J Ther , vol.16 , pp. 354-364
    • Rothman, R.B.1    Baumann, M.H.2
  • 38
    • 35148885200 scopus 로고    scopus 로고
    • Pancreatic lipase inhibitors from natural sources: unexplored potential
    • DOI 10.1016/j.drudis.2007.07.024, PII S1359644607003078
    • RB Birari KK Bhutani 2007 Pancreatic lipase inhibitors from natural sources: unexplored potential Drug Discov Today 12 879 889 17933690 1:CAS:528:DC%2BD2sXhtFKit77J (Pubitemid 47539967)
    • (2007) Drug Discovery Today , vol.12 , Issue.19-20 , pp. 879-889
    • Birari, R.B.1    Bhutani, K.K.2
  • 40
    • 73949084345 scopus 로고    scopus 로고
    • Weight loss, HbA 1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: Comparison with orlistat (xenical)
    • 19461584 1:CAS:528:DC%2BD1MXhs1Sqt7vE
    • P Kopelman GH De Groot A Rissanen, et al. 2010 Weight loss, HbA 1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: comparison with orlistat (xenical) Obesity 18 108 115 19461584 1:CAS:528:DC%2BD1MXhs1Sqt7vE
    • (2010) Obesity , vol.18 , pp. 108-115
    • Kopelman, P.1    De Groot, G.H.2    Rissanen, A.3
  • 41
    • 56549091924 scopus 로고    scopus 로고
    • New approaches to target microsomal triglyceride transfer protein
    • 18957879 1:CAS:528:DC%2BD1cXht12gu7vM
    • MM Hussain A Bakillah 2008 New approaches to target microsomal triglyceride transfer protein Curr Opin Lipidol 19 572 578 18957879 1:CAS:528:DC%2BD1cXht12gu7vM
    • (2008) Curr Opin Lipidol , vol.19 , pp. 572-578
    • Hussain, M.M.1    Bakillah, A.2
  • 42
    • 79959381980 scopus 로고    scopus 로고
    • JNJ-16269110, an enterically targetted microsomal triglyceride transfer protein inhibitor, lowers body weight in overweight/obese subjects
    • L Van Gaal F Vercruysse E Wajs J Xie D Ways L van Nueten 2010 JNJ-16269110, an enterically targetted microsomal triglyceride transfer protein inhibitor, lowers body weight in overweight/obese subjects Obes Rev 11 supplement 1 43
    • (2010) Obes Rev , vol.11 , Issue.SUPPL. 1 , pp. 43
    • Van Gaal, L.1    Vercruysse, F.2    Wajs, E.3    Xie, J.4    Ways, D.5    Van Nueten, L.6
  • 43
    • 14744304497 scopus 로고    scopus 로고
    • Inhibition of triglyceride synthesis as a treatment strategy for obesity: Lessons from DGAT1-deficient mice
    • DOI 10.1161/01.ATV.0000151874.81059.ad
    • HC Chen RV Farese Jr 2005 Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice Arterioscler Thromb Vasc Biol 25 482 486 15569818 1:CAS:528:DC%2BD2MXhtl2ktLc%3D (Pubitemid 40330925)
    • (2005) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.25 , Issue.3 , pp. 482-486
    • Chen, H.C.1    Farese Jr., R.V.2
  • 44
    • 67650096808 scopus 로고    scopus 로고
    • Beyond triglyceride synthesis: The dynamic functional roles of MGAT and DGAT enzymes in energy metabolism
    • 19116371 1:CAS:528:DC%2BD1MXovVKjtrw%3D
    • YG Shi D Cheng 2009 Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism Am J Physiol Endocrinol Metab 297 E10 E18 19116371 1:CAS:528:DC%2BD1MXovVKjtrw%3D
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Shi, Y.G.1    Cheng, D.2
  • 45
    • 84856307048 scopus 로고    scopus 로고
    • AstraZeneca Accessdate August 15, 2010
    • AstraZeneca. Pipepline summary 2010; http://www.astrazeneca.com/research/ our-pipeline-summary/. Access date August 15, 2010.
    • Pipepline Summary 2010
  • 46
    • 58149357463 scopus 로고    scopus 로고
    • Sodium-glucose co-transporter-2 inhibitors: An emerging new class of oral antidiabetic drug
    • 1:CAS:528:DC%2BD1MXivVWjtrc%3D
    • I Idris R Donnelly 2009 Sodium-glucose co-transporter-2 inhibitors: an emerging new class of oral antidiabetic drug Diab Obes Metab 11 79 88 1:CAS:528:DC%2BD1MXivVWjtrc%3D
    • (2009) Diab Obes Metab , vol.11 , pp. 79-88
    • Idris, I.1    Donnelly, R.2
  • 47
    • 84856307006 scopus 로고    scopus 로고
    • Johnson & Johnson Selective highlights as of 7/20/2010
    • Johnson & Johnson. Pharmaceutical pipeline - recent approvals/potential filings. Selective highlights as of 7/20/2010. http://files.shareholder.com/downloads/JNJ/990821560x0x387659/ f0fa5052-2cba-4402-91ab-b40b1fbd5e76/Q22010pipeline.pdf.
    • Pharmaceutical Pipeline - Recent Approvals/potential Filings
  • 48
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • DOI 10.1038/4441022a, PII 4441022A
    • RE Ley PJ Turnbaugh S Klein JI Gordon 2006 Microbial ecology: human gut microbes associated with obesity Nature 444 1022 1023 17183309 1:CAS:528:DC%2BD28XhtlemtLvM (Pubitemid 46018512)
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 49
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • DOI 10.1038/nature05414, PII NATURE05414
    • PJ Turnbaugh RE Ley MA Mahowald V Magrini ER Mardis JI Gordon 2006 An obesity-associated gut microbiome with increased capacity for energy harvest Nature 444 1027 1031 17183312 (Pubitemid 46018515)
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 50
    • 77949363140 scopus 로고    scopus 로고
    • Vancomycin treatment of infective endocarditis is linked with recently acquired obesity
    • 20161775
    • F Thuny H Richet J-P Casalta E Angelakis G Habib D Raoult 2010 Vancomycin treatment of infective endocarditis is linked with recently acquired obesity PLoS ONE 5 e9074 20161775
    • (2010) PLoS ONE , vol.5 , pp. 9074
    • Thuny, F.1    Richet, H.2    Casalta, J.-P.3    Angelakis, E.4    Habib, G.5    Raoult, D.6
  • 51
    • 56749154840 scopus 로고    scopus 로고
    • A gut feeling for obesity: 7TM sensors on enteroendocrine cells
    • 19041758 1:CAS:528:DC%2BD1cXhsV2qtbjJ
    • MS Engelstoft KL Egerod B Holst TW Schwartz 2008 A gut feeling for obesity: 7TM sensors on enteroendocrine cells Cell Metab 8 447 449 19041758 1:CAS:528:DC%2BD1cXhsV2qtbjJ
    • (2008) Cell Metab , vol.8 , pp. 447-449
    • Engelstoft, M.S.1    Egerod, K.L.2    Holst, B.3    Schwartz, T.W.4
  • 52
    • 77649085155 scopus 로고    scopus 로고
    • Gastrointestinal targets of appetite regulation in humans: ILSI Supplement
    • 20433660 1:CAS:528:DC%2BC3cXktlSmsbY%3D
    • N Delzenne J Blundell F Brouns, et al. 2010 Gastrointestinal targets of appetite regulation in humans: ILSI Supplement Obes Rev 11 234 250 20433660 1:CAS:528:DC%2BC3cXktlSmsbY%3D
    • (2010) Obes Rev , vol.11 , pp. 234-250
    • Delzenne, N.1    Blundell, J.2    Brouns, F.3
  • 53
    • 34948839445 scopus 로고    scopus 로고
    • Relationship between stress, eating behavior, and obesity
    • DOI 10.1016/j.nut.2007.08.008, PII S0899900707002493
    • SJ Torres CA Nowson 2007 Relationship between stress, eating behavior, and obesity Nutrition 23 887 894 17869482 (Pubitemid 47532398)
    • (2007) Nutrition , vol.23 , Issue.11-12 , pp. 887-894
    • Torres, S.J.1    Nowson, C.A.2
  • 54
    • 33846032275 scopus 로고    scopus 로고
    • Gastrointestinal regulation of food intake
    • DOI 10.1172/JCI30227
    • DE Cummings J Overduin 2007 Gastrointestinal regulation of food intake J Clin Invest 117 13 23 17200702 1:CAS:528:DC%2BD2sXmvV2rsg%3D%3D (Pubitemid 46048445)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.1 , pp. 13-23
    • Cummings, D.E.1    Overduin, J.2
  • 55
    • 66649112489 scopus 로고    scopus 로고
    • Molecular targets for obesity therapy in the brain
    • 19372196 1:CAS:528:DC%2BD1MXmvVCqt7o%3D
    • S Obici 2009 Molecular targets for obesity therapy in the brain Endocrinology 150 2512 2517 19372196 1:CAS:528:DC%2BD1MXmvVCqt7o%3D
    • (2009) Endocrinology , vol.150 , pp. 2512-2517
    • Obici, S.1
  • 56
    • 68949177102 scopus 로고    scopus 로고
    • Gut hormones: Implications for the treatment of obesity
    • 19560488 1:CAS:528:DC%2BD1MXhtVegsLvM
    • MT Neary RL Batterham 2009 Gut hormones: implications for the treatment of obesity Pharmacol Ther 124 44 56 19560488 1:CAS:528:DC%2BD1MXhtVegsLvM
    • (2009) Pharmacol Ther , vol.124 , pp. 44-56
    • Neary, M.T.1    Batterham, R.L.2
  • 57
    • 67649654283 scopus 로고    scopus 로고
    • Acting in good taste: Nutrient sensors in the gut
    • 19520884 1:CAS:528:DC%2BD1MXovFSktLs%3D
    • KS Yan PJ Pasricha 2009 Acting in good taste: nutrient sensors in the gut Gut 58 897 898 19520884 1:CAS:528:DC%2BD1MXovFSktLs%3D
    • (2009) Gut , vol.58 , pp. 897-898
    • Yan, K.S.1    Pasricha, P.J.2
  • 58
    • 61749098462 scopus 로고    scopus 로고
    • Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes
    • 19039089 1:CAS:528:DC%2BD1MXjsFGgt7w%3D
    • RL Young K Sutherland N Pezos, et al. 2009 Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes Gut 58 337 346 19039089 1:CAS:528:DC%2BD1MXjsFGgt7w%3D
    • (2009) Gut , vol.58 , pp. 337-346
    • Young, R.L.1    Sutherland, K.2    Pezos, N.3
  • 59
    • 76249083555 scopus 로고    scopus 로고
    • Endocannabinoids selectively enhance sweet taste
    • 20080779 1:CAS:528:DC%2BC3cXhtVyqurc%3D
    • R Yoshida T Ohkuri M Jyotaki, et al. 2010 Endocannabinoids selectively enhance sweet taste Proc Natl Acad Sci 107 935 939 20080779 1:CAS:528: DC%2BC3cXhtVyqurc%3D
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 935-939
    • Yoshida, R.1    Ohkuri, T.2    Jyotaki, M.3
  • 60
    • 77956397360 scopus 로고    scopus 로고
    • Peptide YY is critical for acylethanolamine receptor GPR119-induced activation of gastrointestinal mucosal responses
    • 20519124 1:CAS:528:DC%2BC3cXnsFyit74%3D
    • HM Cox IR Tough A-M Woolston, et al. 2010 Peptide YY is critical for acylethanolamine receptor GPR119-induced activation of gastrointestinal mucosal responses Cell Metab 11 532 542 20519124 1:CAS:528:DC%2BC3cXnsFyit74%3D
    • (2010) Cell Metab , vol.11 , pp. 532-542
    • Cox, H.M.1    Tough, I.R.2    Woolston, A.-M.3
  • 61
    • 77149151891 scopus 로고    scopus 로고
    • Nutrient sensing in de gastrointestinal tract
    • 19918174
    • DH Alpers 2010 Nutrient sensing in de gastrointestinal tract Curr Opin Gastroenterol 26 134 139 19918174
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 134-139
    • Alpers, D.H.1
  • 62
    • 67651146366 scopus 로고    scopus 로고
    • N-acylethanolamines, anandamide and food intake
    • 19413995 1:CAS:528:DC%2BD1MXpt1Kls70%3D
    • HS Hansen TA Diep 2009 N-acylethanolamines, anandamide and food intake Biochem Pharmacol 78 553 560 19413995 1:CAS:528:DC%2BD1MXpt1Kls70%3D
    • (2009) Biochem Pharmacol , vol.78 , pp. 553-560
    • Hansen, H.S.1    Diep, T.A.2
  • 63
    • 77649275461 scopus 로고    scopus 로고
    • Cannabinoids and the gut: New developments and emerging concepts
    • 20117132 1:CAS:528:DC%2BC3cXjt1Kgs7g%3D
    • AA Izzo KA Sharkey 2010 Cannabinoids and the gut: new developments and emerging concepts Pharmacol Ther 126 21 38 20117132 1:CAS:528: DC%2BC3cXjt1Kgs7g%3D
    • (2010) Pharmacol Ther , vol.126 , pp. 21-38
    • Izzo, A.A.1    Sharkey, K.A.2
  • 64
    • 67649913243 scopus 로고    scopus 로고
    • GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis
    • 19282326 1:CAS:528:DC%2BD1MXmtlGmtr0%3D
    • H Lan G Vassileva A Corona, et al. 2009 GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis J Endocrinol 201 219 230 19282326 1:CAS:528: DC%2BD1MXmtlGmtr0%3D
    • (2009) J Endocrinol , vol.201 , pp. 219-230
    • Lan, H.1    Vassileva, G.2    Corona, A.3
  • 65
    • 65549142522 scopus 로고    scopus 로고
    • GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell
    • 19208912 1:CAS:528:DC%2BD1MXls1Sqs7s%3D
    • LM Lauffer R Iakoubov PL Brubaker 2009 GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell Diabetes 58 1058 1066 19208912 1:CAS:528: DC%2BD1MXls1Sqs7s%3D
    • (2009) Diabetes , vol.58 , pp. 1058-1066
    • Lauffer, L.M.1    Iakoubov, R.2    Brubaker, P.L.3
  • 66
    • 33846177900 scopus 로고    scopus 로고
    • Mechanism of oleoylethanolamide on fatty acid uptake in small intestine after food intake and body weight reduction
    • 16902188 1:CAS:528:DC%2BD2sXisFGiur4%3D
    • Y Yang M Chen KE Georgeson CM Harmon 2007 Mechanism of oleoylethanolamide on fatty acid uptake in small intestine after food intake and body weight reduction Am J Physiol Regul Integr Comp Physiol 292 R235 R241 16902188 1:CAS:528:DC%2BD2sXisFGiur4%3D
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.292
    • Yang, Y.1    Chen, M.2    Georgeson, K.E.3    Harmon, C.M.4
  • 67
    • 33644627958 scopus 로고    scopus 로고
    • Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents
    • 16517404 1:CAS:528:DC%2BD28Xislyhtr8%3D
    • HA Overton AJ Babbs SM Doel, et al. 2006 Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents Cell Metab 3 167 175 16517404 1:CAS:528:DC%2BD28Xislyhtr8%3D
    • (2006) Cell Metab , vol.3 , pp. 167-175
    • Overton, H.A.1    Babbs, A.J.2    Doel, S.M.3
  • 68
    • 35748951280 scopus 로고    scopus 로고
    • Chapter 9: New nonpeptide-binding GPCRs as targets for diabetes and the metabolic syndrome
    • Fyfe MCT, Overton HA, Procter MJ, Reynet C, White JR. Chapter 9: new nonpeptide-binding GPCRs as targets for diabetes and the metabolic syndrome. Annu Rep Med Chem. 2007;129-45.
    • (2007) Annu Rep Med Chem. , pp. 129-145
    • McT, F.1    Overton, H.A.2    Procter, M.J.3    Reynet, C.4    White, J.R.5
  • 69
    • 40349114501 scopus 로고    scopus 로고
    • GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity
    • 18037923 1:CAS:528:DC%2BD1cXislSjt7g%3D
    • HA Overton MCT Fyfe C Reynet 2008 GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity Br J Pharmacol 153 S76 S81 18037923 1:CAS:528:DC%2BD1cXislSjt7g%3D
    • (2008) Br J Pharmacol , vol.153
    • Overton, H.A.1    Fyfe, M.C.T.2    Reynet, C.3
  • 70
  • 71
    • 51849099001 scopus 로고    scopus 로고
    • Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119
    • 18698756 1:CAS:528:DC%2BD1cXpslahuro%3D
    • G Semple B Fioravanti G Pereira, et al. 2008 Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119 J Med Chem 51 5172 5175 18698756 1:CAS:528:DC%2BD1cXpslahuro%3D
    • (2008) J Med Chem , vol.51 , pp. 5172-5175
    • Semple, G.1    Fioravanti, B.2    Pereira, G.3
  • 72
    • 77950062510 scopus 로고    scopus 로고
    • 2, 5-Disubstituted pyridines as potent GPR119 agonists
    • 20227877 1:CAS:528:DC%2BC3cXksVGnsrk%3D
    • Y Wu JD Kuntz AJ Carpenter, et al. 2010 2, 5-Disubstituted pyridines as potent GPR119 agonists Bioorg Med Chem Lett 20 2577 2581 20227877 1:CAS:528:DC%2BC3cXksVGnsrk%3D
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 2577-2581
    • Wu, Y.1    Kuntz, J.D.2    Carpenter, A.J.3
  • 73
    • 84856306394 scopus 로고    scopus 로고
    • Arena Pharmaceuticals Accessed August 20, 2010
    • Arena Pharmaceuticals. APD597 for type 2 diabetes. Accessed August 20, 2010. http://www.arenapharm.com/apd597.aspx?p=2.6.
    • APD597 for Type 2 Diabetes
  • 75
    • 42349096470 scopus 로고    scopus 로고
    • The role of the endocannabinoid system in the regulation of hypothalamic-pituitary-adrenal axis activity
    • DOI 10.1111/j.1365-2826.2008.01673.x
    • D Cota 2008 The role of the endocannabinoid system in the regulation of hypothalamic-pituitary-adrenal axis activity J Neuroendocrinol 20 35 38 18426497 1:CAS:528:DC%2BD1cXlsl2itbc%3D (Pubitemid 351552674)
    • (2008) Journal of Neuroendocrinology , vol.20 , Issue.SUPPL. 1 , pp. 35-38
    • Cota, D.1
  • 76
    • 70350347327 scopus 로고    scopus 로고
    • CB1 antagonists for obesity; What lessons have we learned from rimonabant?
    • 19844251
    • V Di Marzo JP Després 2009 CB1 antagonists for obesity; what lessons have we learned from rimonabant? Nat Rev Endocrinol 5 633 638 19844251
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 633-638
    • Di Marzo, V.1    Després, J.P.2
  • 77
    • 34147130777 scopus 로고    scopus 로고
    • Integrated physiology and pathophysiology of CB1-mediated effects of the endocannabinoid system
    • DOI 10.1016/j.diabet.2007.02.002, PII S1262363607000547
    • PV Piazza M Lafontan J Girard 2007 Integrated physiology and pathophysiology of CB1-mediated effects of the endocannabinoid system Diabetes Metabol 33 97 107 1:CAS:528:DC%2BD2sXmvFGkurs%3D (Pubitemid 46561389)
    • (2007) Diabetes and Metabolism , vol.33 , Issue.2 , pp. 97-107
    • Piazza, P.V.1    Lafontan, M.2    Girard, J.3
  • 78
    • 57049102251 scopus 로고    scopus 로고
    • End of the line for cannabinoid receptor 1 as an anti-obesity target?
    • 19043439 1:CAS:528:DC%2BD1cXhsVenurbO
    • D Jones 2008 End of the line for cannabinoid receptor 1 as an anti-obesity target? Nat Rev Drug Discov 7 961 962 19043439 1:CAS:528: DC%2BD1cXhsVenurbO
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 961-962
    • Jones, D.1
  • 79
    • 77952541313 scopus 로고    scopus 로고
    • The endocannabinoid system, eating behavior and energy homeostasis: The end or a new beginning?
    • 20347862 1:CAS:528:DC%2BC3cXlvVGls7w%3D
    • FJ Bermudez-Silva MP Viveros JM McPartland F Rodriguez de Fonseca 2010 The endocannabinoid system, eating behavior and energy homeostasis: the end or a new beginning? Pharmacol Biochem Behav 95 375 382 20347862 1:CAS:528: DC%2BC3cXlvVGls7w%3D
    • (2010) Pharmacol Biochem Behav , vol.95 , pp. 375-382
    • Bermudez-Silva, F.J.1    Viveros, M.P.2    McPartland, J.M.3    Rodriguez De Fonseca, F.4
  • 81
    • 69549109976 scopus 로고    scopus 로고
    • Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats
    • 1:CAS:528:DC%2BD1MXot1Glsrw%3D
    • K Sink K Segovia E Nunes, et al. 2009 Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats Psychopharmacology (Berl) 206 223 232 1:CAS:528:DC%2BD1MXot1Glsrw%3D
    • (2009) Psychopharmacology (Berl) , vol.206 , pp. 223-232
    • Sink, K.1    Segovia, K.2    Nunes, E.3
  • 82
    • 77949539755 scopus 로고    scopus 로고
    • Peripherally acting CB1-receptor antagonist: The relative importance of central and peripheral CB1 receptors in adiposity control
    • 1:CAS:528:DC%2BC3cXjt1GntLo%3D
    • MH Son HD Kim YN Chae, et al. 2010 Peripherally acting CB1-receptor antagonist: the relative importance of central and peripheral CB1 receptors in adiposity control Int J Obes 34 547 556 1:CAS:528:DC%2BC3cXjt1GntLo%3D
    • (2010) Int J Obes , vol.34 , pp. 547-556
    • Son, M.H.1    Kim, H.D.2    Chae, Y.N.3
  • 83
    • 75749126604 scopus 로고    scopus 로고
    • Signal transduction of the CB1 cannabinoid receptor
    • 19620237 1:CAS:528:DC%2BC3cXhvFSitr0%3D
    • G Turu L Hunyady 2010 Signal transduction of the CB1 cannabinoid receptor J Mol Endocrinol 44 75 85 19620237 1:CAS:528:DC%2BC3cXhvFSitr0%3D
    • (2010) J Mol Endocrinol , vol.44 , pp. 75-85
    • Turu, G.1    Hunyady, L.2
  • 84
    • 41249100938 scopus 로고    scopus 로고
    • Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor
    • 18336811 1:CAS:528:DC%2BD1cXksVaqs7o%3D
    • RZ Chen A Frassetto JZ Lao, et al. 2008 Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor Eur J Pharmacol 584 338 342 18336811 1:CAS:528:DC%2BD1cXksVaqs7o%3D
    • (2008) Eur J Pharmacol , vol.584 , pp. 338-342
    • Chen, R.Z.1    Frassetto, A.2    Lao, J.Z.3
  • 85
    • 72249112327 scopus 로고    scopus 로고
    • Conversion of 4-cyanomethyl-pyrazole-3-carboxamides into CB1 antagonists with lowered propensity to pass the blood-brain-barrier
    • 20015647 1:CAS:528:DC%2BD1MXhsF2itb7I
    • JM Receveur A Murray JM Linget, et al. 2010 Conversion of 4-cyanomethyl-pyrazole-3-carboxamides into CB1 antagonists with lowered propensity to pass the blood-brain-barrier Bioorg Med Chem Lett 20 453 457 20015647 1:CAS:528:DC%2BD1MXhsF2itb7I
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 453-457
    • Receveur, J.M.1    Murray, A.2    Linget, J.M.3
  • 86
    • 79961167575 scopus 로고    scopus 로고
    • A single ascending dose study of TM38837-a novel second generation peripheral selective CB1 receptor antagonist in health male volunteers
    • M Fridberg PB Little M Cooper NO Jensen CE Elling 2010 A single ascending dose study of TM38837-a novel second generation peripheral selective CB1 receptor antagonist in health male volunteers Obes Rev 10 supplement 1 180
    • (2010) Obes Rev , vol.10 , Issue.SUPPL. 1 , pp. 180
    • Fridberg, M.1    Little, P.B.2    Cooper, M.3    Jensen, N.O.4    Elling, C.E.5
  • 87
    • 66649134711 scopus 로고    scopus 로고
    • Gut peptides: Targets for antiobesity drug development?
    • 19372201 1:CAS:528:DC%2BD1MXmvVCqt7g%3D
    • TH Moran MJ Dailey 2009 Gut peptides: targets for antiobesity drug development? Endocrinology 150 2526 2530 19372201 1:CAS:528:DC%2BD1MXmvVCqt7g%3D
    • (2009) Endocrinology , vol.150 , pp. 2526-2530
    • Moran, T.H.1    Dailey, M.J.2
  • 89
    • 69749086148 scopus 로고    scopus 로고
    • Enhanced weight loss with pramlintide/metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy
    • 1:CAS:528:DC%2BD1MXhtVKkurnF
    • E Ravussin 2009 Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy Obesity (Silver Spring) 17 1736 1743 1:CAS:528:DC%2BD1MXhtVKkurnF
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1736-1743
    • Ravussin, E.1
  • 93
    • 84856313113 scopus 로고    scopus 로고
    • Accessed August 15, 2010
    • 7 TM Pharma. TM 30339 in gastrointestinal disorders. Accessed August 15, 2010 http://www.7tm.com/R-D/Gastrointestinal-Disorders.aspx.
    • TM 30339 in Gastrointestinal Disorders
  • 94
    • 84856308815 scopus 로고    scopus 로고
    • Accessed August 15 2010
    • 7TM Pharma. Information on Obinepitide. Accessed August 15 2010. http://www.7tm.com/R-D/Metabolic-Disorders/Obinepitide.aspx.
    • Information on Obinepitide
  • 95
    • 74049084094 scopus 로고    scopus 로고
    • Market watch: Upcoming market catalysts in Q1 of 2010
    • 20043022 1:CAS:528:DC%2BD1MXhs1aqtbfJ
    • J Rosenthal 2010 Market watch: upcoming market catalysts in Q1 of 2010 Nat Rev Drug Discov 9 11 20043022 1:CAS:528:DC%2BD1MXhs1aqtbfJ
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 11
    • Rosenthal, J.1
  • 96
    • 70350619609 scopus 로고    scopus 로고
    • Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
    • 19853906 1:CAS:528:DC%2BD1MXhtlyjtLrL
    • A Astrup S Rössner L Van Gaal, et al. 2009 Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study Lancet 374 1606 1616 19853906 1:CAS:528:DC%2BD1MXhtlyjtLrL
    • (2009) Lancet , vol.374 , pp. 1606-1616
    • Astrup, A.1    Rössner, S.2    Van Gaal, L.3
  • 99
    • 38349104637 scopus 로고    scopus 로고
    • Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients
    • 17597711 1:CAS:528:DC%2BD1cXitFKjtbk%3D
    • J Jordan FL Greenway LA Leiter, et al. 2008 Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients Clin Pharmacol Ther 83 281 287 17597711 1:CAS:528:DC%2BD1cXitFKjtbk%3D
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 281-287
    • Jordan, J.1    Greenway, F.L.2    Leiter, L.A.3
  • 100
    • 0035433977 scopus 로고    scopus 로고
    • A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans
    • DE Cummings JQ Purnell RS Frayo K Schmidova BE Wisse DS Weigle 2001 A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans Diabetes 50 1714 1719 11473029 1:CAS:528:DC%2BD3MXlslKnurw%3D (Pubitemid 33641587)
    • (2001) Diabetes , vol.50 , Issue.8 , pp. 1714-1719
    • Cummings, D.E.1    Purnell, J.Q.2    Frayo, R.S.3    Schmidova, K.4    Wisse, B.E.5    Weigle, D.S.6
  • 101
    • 77953194478 scopus 로고    scopus 로고
    • Ghrelin increases intake of rewarding food in rodents
    • 20477752 1:CAS:528:DC%2BC3cXps1ahu7s%3D
    • E Egecioglu E Jerlhag N Salomé, et al. 2010 Ghrelin increases intake of rewarding food in rodents Addict Biol 15 304 311 20477752 1:CAS:528:DC%2BC3cXps1ahu7s%3D
    • (2010) Addict Biol , vol.15 , pp. 304-311
    • Egecioglu, E.1    Jerlhag, E.2    Salomé, N.3
  • 102
    • 49449085708 scopus 로고    scopus 로고
    • Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides
    • 18669668 1:CAS:528:DC%2BD1cXpvFOjur8%3D
    • J Yang TJ Zhao JL Goldstein MS Brown 2008 Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides Proc Natl Acad Sci USA 105 10750 10755 18669668 1:CAS:528:DC%2BD1cXpvFOjur8%3D
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 10750-10755
    • Yang, J.1    Zhao, T.J.2    Goldstein, J.L.3    Brown, M.S.4
  • 104
    • 69249178180 scopus 로고    scopus 로고
    • On the central mechanism underlying ghrelin's chronic pro-obesity effects in rats: New insights from studies exploiting a potent ghrelin receptor antagonist
    • 19703102
    • N Salomé C Hansson M Taube, et al. 2009 On the central mechanism underlying ghrelin's chronic pro-obesity effects in rats: new insights from studies exploiting a potent ghrelin receptor antagonist J Neuroendocrinol 21 777 785 19703102
    • (2009) J Neuroendocrinol , vol.21 , pp. 777-785
    • Salomé, N.1    Hansson, C.2    Taube, M.3
  • 106
    • 34347329282 scopus 로고    scopus 로고
    • Active immunization against ghrelin decreases weight gain and alters plasma concentrations of growth hormone in growing pigs
    • DOI 10.1016/j.domaniend.2006.05.005, PII S0739724006001123
    • JA Vizcarra JD Kirby SK Kim ML Galyean 2007 Active immunization against ghrelin decreases weight gain and alters plasma concentrations of growth hormone in growing pigs Domest Anim Endocrinol 33 176 189 16793235 1:CAS:528: DC%2BD2sXnsFymt7k%3D (Pubitemid 47016890)
    • (2007) Domestic Animal Endocrinology , vol.33 , Issue.2 , pp. 176-189
    • Vizcarra, J.A.1    Kirby, J.D.2    Kim, S.K.3    Galyean, M.L.4
  • 107
    • 70449717071 scopus 로고    scopus 로고
    • CNS-targets in control of energy and glucose homeostasis
    • 19884043 1:CAS:528:DC%2BD1MXhsVGqs7jM
    • A Kleinridders AC Könner JC Brüning 2009 CNS-targets in control of energy and glucose homeostasis Curr Opin Pharmacol 9 794 804 19884043 1:CAS:528:DC%2BD1MXhsVGqs7jM
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 794-804
    • Kleinridders, A.1    Könner, A.C.2    Brüning, J.C.3
  • 108
    • 33748931457 scopus 로고    scopus 로고
    • Central nervous system control of food intake and body weight
    • DOI 10.1038/nature05026, PII NATURE05026
    • GJ Morton DE Cummings DG Baskin GS Barsh MW Schwartz 2006 Central nervous system control of food intake and body weight Nature 443 289 295 16988703 1:CAS:528:DC%2BD28Xpslalu7c%3D (Pubitemid 44435142)
    • (2006) Nature , vol.443 , Issue.7109 , pp. 289-295
    • Morton, G.J.1    Cummings, D.E.2    Baskin, D.G.3    Barsh, G.S.4    Schwartz, M.W.5
  • 109
    • 52249100710 scopus 로고    scopus 로고
    • Neuroendocrine control of food intake
    • Valassi E, Scacchi M, Cavagnini F. Neuroendocrine control of food intake. NMCD. 2007;1-10.
    • (2007) NMCD , pp. 1-10
    • Valassi, E.1    Scacchi, M.2    Cavagnini, F.3
  • 110
    • 33846003865 scopus 로고    scopus 로고
    • Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cessation agent
    • DOI 10.1111/j.1527-3458.2006.00178.x
    • LP Dwoskin AS Rauhut KA King-Pospisil MT Bardo 2006 Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cessation agent CNS Drug Rev 12 178 207 17227286 (Pubitemid 46047787)
    • (2006) CNS Drug Reviews , vol.12 , Issue.3-4 , pp. 178-207
    • Dwoskin, L.P.1    Rauhut, A.S.2    King-Pospisil, K.A.3    Bardo, M.T.4
  • 111
    • 77952584236 scopus 로고    scopus 로고
    • Central and peripheral molecular targets for antiobesity pharmacotherapy
    • 20445536 1:STN:280:DC%2BC3czksFyjtQ%3D%3D
    • MA Valentino JE Lin SA Waldman 2010 Central and peripheral molecular targets for antiobesity pharmacotherapy Clin Pharmacol Ther 87 652 662 20445536 1:STN:280:DC%2BC3czksFyjtQ%3D%3D
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 652-662
    • Valentino, M.A.1    Lin, J.E.2    Waldman, S.A.3
  • 112
    • 56649112848 scopus 로고    scopus 로고
    • Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: A randomised, double-blind, placebo-controlled trial
    • 18950853 1:CAS:528:DC%2BD1cXhsVelurfO
    • A Astrup S Madsbad L Breum TJ Jensen JP Kroustrup TM Larsen 2008 Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial Lancet 372 1906 1913 18950853 1:CAS:528:DC%2BD1cXhsVelurfO
    • (2008) Lancet , vol.372 , pp. 1906-1913
    • Astrup, A.1    Madsbad, S.2    Breum, L.3    Jensen, T.J.4    Kroustrup, J.P.5    Larsen, T.M.6
  • 116
    • 58149301316 scopus 로고    scopus 로고
    • Pharmacological targeting of the serotonergic system for the treatment of obesity
    • 1:CAS:528:DC%2BD1MXhtVKls70%3D
    • AS Garfield LK Heisler 2009 Pharmacological targeting of the serotonergic system for the treatment of obesity J Physiol (Lond) 587 49 60 1:CAS:528:DC%2BD1MXhtVKls70%3D
    • (2009) J Physiol (Lond) , vol.587 , pp. 49-60
    • Garfield, A.S.1    Heisler, L.K.2
  • 118
  • 119
    • 38549144692 scopus 로고    scopus 로고
    • Selective 5-HT6 receptor ligands: Progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders
    • 18068807 1:CAS:528:DC%2BD1cXhtV2itrY%3D
    • DJ Heal SL Smith A Fisas X Codony H Buschmann 2008 Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders Pharmacol Ther 117 207 231 18068807 1:CAS:528:DC%2BD1cXhtV2itrY%3D
    • (2008) Pharmacol Ther , vol.117 , pp. 207-231
    • Heal, D.J.1    Smith, S.L.2    Fisas, A.3    Codony, X.4    Buschmann, H.5
  • 120
    • 60849103765 scopus 로고    scopus 로고
    • Lorcaserin (APD356), a selective 5-HT2C agonist, reduces body weight in obese men and women
    • 1:CAS:528:DC%2BD1MXit1Oiu7Y%3D
    • SR Smith 2009 Lorcaserin (APD356), a selective 5-HT2C agonist, reduces body weight in obese men and women Obesity (Silver Spring) 17 494 503 1:CAS:528:DC%2BD1MXit1Oiu7Y%3D
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 494-503
    • Smith, S.R.1
  • 122
    • 41949090001 scopus 로고    scopus 로고
    • 3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity
    • 18329700 1:CAS:528:DC%2BD1cXkvVOqsro%3D
    • 3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity Pharmacol Biochem Behav 89 499 507 18329700 1:CAS:528:DC%2BD1cXkvVOqsro%3D
    • (2008) Pharmacol Biochem Behav , vol.89 , pp. 499-507
    • Thanos, P.K.1    Michaelides, M.2    Ho, C.W.3
  • 124
    • 33746578394 scopus 로고    scopus 로고
    • Design and synthesis of (ant)-agonists that alter appetite and adiposity
    • 16876570
    • LH Van der Ploeg 2006 Design and synthesis of (ant)-agonists that alter appetite and adiposity Prog Brain Res 153 107 118 16876570
    • (2006) Prog Brain Res , vol.153 , pp. 107-118
    • Van Der Ploeg, L.H.1
  • 125
    • 68949205198 scopus 로고    scopus 로고
    • Promising strategies for obesity pharmacotherapy: Melanocortin-4 (MC-4) receptor agonists and melanin concentrating hormone (MCH) receptor-1 antagonists
    • 19689363 1:CAS:528:DC%2BD1MXhtVGntr3I
    • MK Jeon HG Cheon 2009 Promising strategies for obesity pharmacotherapy: Melanocortin-4 (MC-4) receptor agonists and melanin concentrating hormone (MCH) receptor-1 antagonists Curr Top Med Chem 9 504 538 19689363 1:CAS:528: DC%2BD1MXhtVGntr3I
    • (2009) Curr Top Med Chem , vol.9 , pp. 504-538
    • Jeon, M.K.1    Cheon, H.G.2
  • 126
    • 70450245171 scopus 로고    scopus 로고
    • Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: Energy intake predicts lack of weight loss efficacy
    • 19741604 1:CAS:528:DC%2BD1MXhsVWmu7jJ
    • R Krishna B Gumbiner C Stevens, et al. 2009 Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy Clin Pharmacol Ther 86 659 666 19741604 1:CAS:528:DC%2BD1MXhsVWmu7jJ
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 659-666
    • Krishna, R.1    Gumbiner, B.2    Stevens, C.3
  • 127
    • 35748948024 scopus 로고    scopus 로고
    • MCH-R1 antagonists: what is keeping most research programs away from the clinic?
    • DOI 10.1016/j.drudis.2007.08.010, PII S1359644607003522
    • JL Méndez-Andino JA Wos 2007 MCH-R1 antagonists: what is keeping most research programs away from the clinic? Drug Discov Today 12 972 979 17993417 (Pubitemid 350052673)
    • (2007) Drug Discovery Today , vol.12 , Issue.21-22 , pp. 972-979
    • Mendez-Andino, J.L.1    Wos, J.A.2
  • 128
    • 33645287272 scopus 로고    scopus 로고
    • Histamine H3 receptor antagonists: Preclinical promise for treating obesity and cognitive disorders
    • 16565470 1:CAS:528:DC%2BD28XjvVansr0%3D
    • TA Esbenshade GB Fox MD Cowart 2006 Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders Mol Interv 6 77 88 16565470 1:CAS:528:DC%2BD28XjvVansr0%3D
    • (2006) Mol Interv , vol.6 , pp. 77-88
    • Esbenshade, T.A.1    Fox, G.B.2    Cowart, M.D.3
  • 129
    • 67349158641 scopus 로고    scopus 로고
    • The histamine H3 receptor as a therapeutic drug target for CNS disorders
    • 19429511 1:CAS:528:DC%2BD1MXltlKqsr8%3D
    • MJ Gemkow AJ Davenport S Harich BA Ellenbroek A Cesura D Hallett 2009 The histamine H3 receptor as a therapeutic drug target for CNS disorders Drug Discov Today 14 509 515 19429511 1:CAS:528:DC%2BD1MXltlKqsr8%3D
    • (2009) Drug Discov Today , vol.14 , pp. 509-515
    • Gemkow, M.J.1    Davenport, A.J.2    Harich, S.3    Ellenbroek, B.A.4    Cesura, A.5    Hallett, D.6
  • 131
    • 53849090615 scopus 로고    scopus 로고
    • Effect of histaminergic manipulation on weight in obese adults: A randomized placebo controlled trial
    • 1:CAS:528:DC%2BD1cXht1aqsr3P
    • N Barak FL Greenway K Fujioka LJ Aronne RF Kushner 2008 Effect of histaminergic manipulation on weight in obese adults: a randomized placebo controlled trial Int J Obes (Lond) 32 1559 1565 1:CAS:528:DC%2BD1cXht1aqsr3P
    • (2008) Int J Obes (Lond) , vol.32 , pp. 1559-1565
    • Barak, N.1    Greenway, F.L.2    Fujioka, K.3    Aronne, L.J.4    Kushner, R.F.5
  • 132
    • 75149160396 scopus 로고    scopus 로고
    • Regulation of energy homeostasis by bombesin receptor subtype-3: Selective receptor agonists for the treatment of obesity
    • 20096642 1:CAS:528:DC%2BC3cXlsVaju7k%3D
    • X-M Guan H Chen PH Dobbelaar, et al. 2010 Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity Cell Metab 11 101 112 20096642 1:CAS:528: DC%2BC3cXlsVaju7k%3D
    • (2010) Cell Metab , vol.11 , pp. 101-112
    • Guan, X.-M.1    Chen, H.2    Dobbelaar, P.H.3
  • 133
    • 77949673935 scopus 로고    scopus 로고
    • PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice
    • 20160350 1:CAS:528:DC%2BC3cXjtV2ns70%3D
    • R Banno D Zimmer BC De Jonghe, et al. 2010 PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice J Clin Investig 120 720 734 20160350 1:CAS:528:DC%2BC3cXjtV2ns70%3D
    • (2010) J Clin Investig , vol.120 , pp. 720-734
    • Banno, R.1    Zimmer, D.2    De Jonghe, B.C.3
  • 134
    • 77955052291 scopus 로고    scopus 로고
    • Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice
    • Lantz KA, Hart SGE, Planey SL, et al. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity. 2010.
    • (2010) Obesity
    • Lantz, K.A.1    Sge, H.2    Planey, S.L.3
  • 136
    • 41549099584 scopus 로고    scopus 로고
    • Recent advances in the discovery and development of PTP-1B inhibitors
    • DOI 10.1358/dof.2008.033.02.1165449
    • S Tam E Saiah 2008 Recent advances in the discovery and development of PTP-1B inhibitors Drugs Future 33 175 185 1:CAS:528:DC%2BD1cXks1Gjtrc%3D (Pubitemid 351462877)
    • (2008) Drugs of the Future , vol.33 , Issue.2 , pp. 175-185
    • Tam, S.1    Saiah, E.2
  • 137
    • 77953169046 scopus 로고    scopus 로고
    • Cellular bioenergetics as a target for obesity therapy
    • 20514071 1:CAS:528:DC%2BC3cXmslWlsro%3D
    • Y-H Tseng AM Cypess CR Kahn 2010 Cellular bioenergetics as a target for obesity therapy Nat Rev Drug Discov 9 465 482 20514071 1:CAS:528: DC%2BC3cXmslWlsro%3D
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 465-482
    • Tseng, Y.-H.1    Cypess, A.M.2    Kahn, C.R.3
  • 138
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • 19357406 1:CAS:528:DC%2BD1MXltlSqsro%3D
    • AM Cypess 2009 Identification and importance of brown adipose tissue in adult humans N Engl J Med 360 1509 1517 19357406 1:CAS:528:DC%2BD1MXltlSqsro%3D
    • (2009) N Engl J Med , vol.360 , pp. 1509-1517
    • Cypess, A.M.1
  • 139
    • 64349095231 scopus 로고    scopus 로고
    • Cold-activated brown adipose tissue in healthy men
    • 19357405
    • WD Marken Lichtenbelt 2009 Cold-activated brown adipose tissue in healthy men N Engl J Med 360 1500 1508 19357405
    • (2009) N Engl J Med , vol.360 , pp. 1500-1508
    • Marken Lichtenbelt, W.D.1
  • 140
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • 19357407 1:CAS:528:DC%2BD1MXltlSqsrs%3D
    • KA Virtanen 2009 Functional brown adipose tissue in healthy adults N Engl J Med 360 1518 1525 19357407 1:CAS:528:DC%2BD1MXltlSqsrs%3D
    • (2009) N Engl J Med , vol.360 , pp. 1518-1525
    • Virtanen, K.A.1
  • 141
  • 143
    • 0036783754 scopus 로고    scopus 로고
    • Effect of a 28-d treatment with L-796568, a novel β3-adrenergic receptor agonist, on energy expenditure and body composition in obese men
    • 12324291 1:CAS:528:DC%2BD38Xns1eqsLg%3D
    • TM Larsen S Toubro MA Van Baak, et al. 2002 Effect of a 28-d treatment with L-796568, a novel β3-adrenergic receptor agonist, on energy expenditure and body composition in obese men Am J Clin Nutr 76 780 788 12324291 1:CAS:528:DC%2BD38Xns1eqsLg%3D
    • (2002) Am J Clin Nutr , vol.76 , pp. 780-788
    • Larsen, T.M.1    Toubro, S.2    Van Baak, M.A.3
  • 144
    • 33846961446 scopus 로고    scopus 로고
    • Lack of an effect of a novel β3-adrenoceptor agonist, TAK-677, on energy metabolism in obese individuals: A double-blind, placebo-controlled randomized study
    • 17118998 1:CAS:528:DC%2BD2sXitVaksb4%3D
    • LM Redman L De Jonge X Fang, et al. 2007 Lack of an effect of a novel β3-adrenoceptor agonist, TAK-677, on energy metabolism in obese individuals: a double-blind, placebo-controlled randomized study J Clin Endocrinol Metab 92 527 531 17118998 1:CAS:528:DC%2BD2sXitVaksb4%3D
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 527-531
    • Redman, L.M.1    De Jonge, L.2    Fang, X.3
  • 145
    • 49649120105 scopus 로고    scopus 로고
    • Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor β subtype selective agonist KB-141
    • 18621127 1:CAS:528:DC%2BD1cXhtVamtb%2FE
    • G Bryzgalova 2008 Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor β subtype selective agonist KB-141 J Steroid Biochem Mol Biol 111 262 267 18621127 1:CAS:528:DC%2BD1cXhtVamtb%2FE
    • (2008) J Steroid Biochem Mol Biol , vol.111 , pp. 262-267
    • Bryzgalova, G.1
  • 146
    • 77953233697 scopus 로고    scopus 로고
    • Sobetirome: A case history of bench-to-clinic drug discovery and development
    • 19002578
    • TS Scanlan 2010 Sobetirome: a case history of bench-to-clinic drug discovery and development Heart Fail Rev 15 177 182 19002578
    • (2010) Heart Fail Rev , vol.15 , pp. 177-182
    • Scanlan, T.S.1
  • 148
    • 72449133267 scopus 로고    scopus 로고
    • Obesity and corticosteroids: 11[beta]-Hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease
    • 19804814 1:CAS:528:DC%2BD1MXhs1WgtbnK
    • NM Morton 2010 Obesity and corticosteroids: 11[beta]-Hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease Mol Cell Endocrinol 316 154 164 19804814 1:CAS:528:DC%2BD1MXhs1WgtbnK
    • (2010) Mol Cell Endocrinol , vol.316 , pp. 154-164
    • Morton, N.M.1
  • 149
    • 26244435944 scopus 로고    scopus 로고
    • Keynote review: The adipocyte as a drug discovery target
    • DOI 10.1016/S1359-6446(05)03569-5, PII S1359644605035695
    • AR Nawrocki PE Scherer 2005 Keynote review: the adipocyte as a drug discovery target Drug Discov Today 10 1219 1230 16213414 1:CAS:528: DC%2BD2MXhtVGgsLzI (Pubitemid 41411432)
    • (2005) Drug Discovery Today , vol.10 , Issue.18 , pp. 1219-1230
    • Nawrocki, A.R.1    Scherer, P.E.2
  • 150
    • 42049088734 scopus 로고    scopus 로고
    • Glucocorticoid antagonists and 11[beta]-HSD1 inhibitors
    • M Wang 2007 Glucocorticoid antagonists and 11[beta]-HSD1 inhibitors Drug Discov Today Ther Strat 4 117 122
    • (2007) Drug Discov Today Ther Strat , vol.4 , pp. 117-122
    • Wang, M.1
  • 151
    • 34447105433 scopus 로고    scopus 로고
    • Inhibition of 11ß-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target
    • DOI 10.1016/j.drudis.2007.06.001, PII S1359644607002280
    • M Wamil JR Seckl 2007 Inhibition of 11-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target Drug Discov Today 12 504 520 17631244 1:CAS:528:DC%2BD2sXnslWlur0%3D (Pubitemid 47031664)
    • (2007) Drug Discovery Today , vol.12 , Issue.13-14 , pp. 504-520
    • Wamil, M.1    Seckl, J.R.2
  • 152
    • 77956489883 scopus 로고    scopus 로고
    • Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes
    • (In Press). doi: 10.1016/j.jsbmb.2010.03.060
    • Gathercole LL, Stewart PM. Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes. J Steroid Biochem Mol Biol. 2010 (In Press). doi: 10.1016/j.jsbmb.2010.03.060.
    • (2010) J Steroid Biochem Mol Biol.
    • Gathercole, L.L.1    Stewart, P.M.2
  • 153
    • 77953182919 scopus 로고    scopus 로고
    • Discovery of a potent, orally active 11Î2-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: Identification of (S)-2-((1S, 2S, 4 R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)
    • 20465278
    • MM Véniant C Hale RW Hungate, et al. 2010 Discovery of a potent, orally active 11Î2-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S, 2S, 4 R)-Bicyclo[2.2.1]heptan-2- ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221) J Med Chem 53 4481 4487 20465278
    • (2010) J Med Chem , vol.53 , pp. 4481-4487
    • Véniant, M.M.1    Hale, C.2    Hungate, R.W.3
  • 154
    • 50249091534 scopus 로고    scopus 로고
    • Blockade of glucocorticoid excess at the tissue level: Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 as a therapy for type 2 diabetes
    • 18652443 1:CAS:528:DC%2BD1cXovVOhs7c%3D
    • C Fotsch M Wang 2008 Blockade of glucocorticoid excess at the tissue level: inhibitors of 11β-hydroxysteroid dehydrogenase type 1 as a therapy for type 2 diabetes J Med Chem 51 4851 4857 18652443 1:CAS:528: DC%2BD1cXovVOhs7c%3D
    • (2008) J Med Chem , vol.51 , pp. 4851-4857
    • Fotsch, C.1    Wang, M.2
  • 155
    • 77954141448 scopus 로고    scopus 로고
    • Discovery of adamantyl ethanone derivatives as potent 11β- hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors
    • 20486152 1:CAS:528:DC%2BC3cXotVOmtL8%3D
    • X Su F Pradaux-Caggiano MP Thomas, et al. 2010 Discovery of adamantyl ethanone derivatives as potent 11β- hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors ChemMedChem 5 1026 1044 20486152 1:CAS:528: DC%2BC3cXotVOmtL8%3D
    • (2010) ChemMedChem , vol.5 , pp. 1026-1044
    • Su, X.1    Pradaux-Caggiano, F.2    Thomas, M.P.3
  • 156
    • 77950265310 scopus 로고    scopus 로고
    • INCB-13739, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor for the treatment of type 2 diabetes
    • 20373256 1:CAS:528:DC%2BC3cXpt1yltrc%3D
    • A Tiwari 2010 INCB-13739, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor for the treatment of type 2 diabetes IDrugs 13 266 275 20373256 1:CAS:528:DC%2BC3cXpt1yltrc%3D
    • (2010) IDrugs , vol.13 , pp. 266-275
    • Tiwari, A.1
  • 157
    • 77953480631 scopus 로고    scopus 로고
    • Biochemical effects of SIRT1 activators
    • 1:CAS:528:DC%2BC3cXntlaltb8%3D
    • JA Baur 2010 Biochemical effects of SIRT1 activators Biochim Biophys Acta: Proteins Proteomics 1804 1626 1634 1:CAS:528:DC%2BC3cXntlaltb8%3D
    • (2010) Biochim Biophys Acta: Proteins Proteomics , vol.1804 , pp. 1626-1634
    • Baur, J.A.1
  • 158
    • 47249108032 scopus 로고    scopus 로고
    • Sirtuins: Novel targets for metabolic disease in drug development
    • 18577374 1:CAS:528:DC%2BD1cXoslGmtbw%3D
    • W-J Jiang 2008 Sirtuins: novel targets for metabolic disease in drug development Biochem Biophys Res Commun 373 341 344 18577374 1:CAS:528: DC%2BD1cXoslGmtbw%3D
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 341-344
    • Jiang, W.-J.1
  • 160
    • 63149150180 scopus 로고    scopus 로고
    • Discovery of oxazolo[4, 5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators
    • 19303289 1:CAS:528:DC%2BD1MXkt1Sjtbc%3D
    • JE Bemis CB Vu R Xie, et al. 2009 Discovery of oxazolo[4, 5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators Bioorg Med Chem Lett 19 2350 2353 19303289 1:CAS:528:DC%2BD1MXkt1Sjtbc%3D
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 2350-2353
    • Bemis, J.E.1    Vu, C.B.2    Xie, R.3
  • 161
    • 54849425547 scopus 로고    scopus 로고
    • Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
    • 19046567 1:CAS:528:DC%2BD1cXhtlOgur7O
    • JN Feige 2008 Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation Cell Metab 8 347 358 19046567 1:CAS:528:DC%2BD1cXhtlOgur7O
    • (2008) Cell Metab , vol.8 , pp. 347-358
    • Feige, J.N.1
  • 162
    • 84856313947 scopus 로고    scopus 로고
    • Accessed August 15th 2010
    • Sitris Pharmaceuticals. Sirtris development pipeline. Accessed August 15th 2010. http://www.sirtrispharma.com/pipeline.html.
    • Sirtris Development Pipeline
  • 163
    • 77950246109 scopus 로고    scopus 로고
    • SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
    • 20061378 1:CAS:528:DC%2BC3cXisl2jtr0%3D
    • M Pacholec JE Bleasdale B Chrunyk, et al. 2010 SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1 J Biol Chem 285 8340 8351 20061378 1:CAS:528:DC%2BC3cXisl2jtr0%3D
    • (2010) J Biol Chem , vol.285 , pp. 8340-8351
    • Pacholec, M.1    Bleasdale, J.E.2    Chrunyk, B.3
  • 165
    • 34347380139 scopus 로고    scopus 로고
    • No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet
    • DOI 10.1111/j.1463-1326.2006.00645.x
    • A Due A Flint G Eriksen, et al. 2007 No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet Diab Obes Metab 9 566 574 1:CAS:528: DC%2BD2sXosF2ltL4%3D (Pubitemid 47018520)
    • (2007) Diabetes, Obesity and Metabolism , vol.9 , Issue.4 , pp. 566-574
    • Due, A.1    Flint, A.2    Eriksen, G.3    Moller, B.4    Raben, A.5    Hansen, J.B.6    Astrup, A.7
  • 166
    • 0036678477 scopus 로고    scopus 로고
    • Adipose tissue mass can be regulated through the vasculature
    • 12149466 1:CAS:528:DC%2BD38Xmt1Cht74%3D
    • MA Rupnick D Panigrahy CY Zhang, et al. 2002 Adipose tissue mass can be regulated through the vasculature Proc Natl Acad Sci USA 99 10730 10735 12149466 1:CAS:528:DC%2BD38Xmt1Cht74%3D
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10730-10735
    • Rupnick, M.A.1    Panigrahy, D.2    Zhang, C.Y.3
  • 167
    • 75849165542 scopus 로고    scopus 로고
    • Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
    • 20118961 1:CAS:528:DC%2BC3cXht1ynsL4%3D
    • Y Cao 2010 Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases Nat Rev Drug Discov 9 107 115 20118961 1:CAS:528:DC%2BC3cXht1ynsL4%3D
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 107-115
    • Cao, Y.1
  • 168
    • 2942716779 scopus 로고    scopus 로고
    • Magic bullets melt fat
    • DOI 10.1038/nm0604-581
    • ML Reitman 2004 Magic bullets melt fat Nat Med 10 581 582 15170200 1:CAS:528:DC%2BD2cXksVaju7k%3D (Pubitemid 38796844)
    • (2004) Nature Medicine , vol.10 , Issue.6 , pp. 581-582
    • Reitman, M.L.1
  • 169
    • 2942703809 scopus 로고    scopus 로고
    • Reversal of obesity by targeted ablation of adipose tissue
    • DOI 10.1038/nm1048
    • MG Kolonin PK Saha L Chan R Pasqualini W Arap 2004 Reversal of obesity by targeted ablation of adipose tissue Nat Med 10 625 632 15133506 1:CAS:528:DC%2BD2cXksVaisrY%3D (Pubitemid 38796854)
    • (2004) Nature Medicine , vol.10 , Issue.6 , pp. 625-632
    • Kolonin, M.G.1    Saha, P.K.2    Chan, L.3    Pasqualini, R.4    Arap, W.5
  • 170
    • 34848851922 scopus 로고    scopus 로고
    • Angiogenesis modulates adipogenesis and obesity
    • DOI 10.1172/JCI32239
    • Y Cao 2007 Angiogenesis modulates adipogenesis and obesity J Clin Invest 117 2362 2368 17786229 1:CAS:528:DC%2BD2sXhtVCms7rM (Pubitemid 47494333)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.9 , pp. 2362-2368
    • Cao, Y.1
  • 171
    • 67349288052 scopus 로고    scopus 로고
    • TGR5: An emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders
    • 19429513 1:CAS:528:DC%2BD1MXltlKqsr0%3D
    • A Tiwari P Maiti 2009 TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders Drug Discov Today 14 523 530 19429513 1:CAS:528:DC%2BD1MXltlKqsr0%3D
    • (2009) Drug Discov Today , vol.14 , pp. 523-530
    • Tiwari, A.1    Maiti, P.2
  • 173
    • 69149083245 scopus 로고    scopus 로고
    • TGR5-mediated bile acid sensing controls glucose homeostasis
    • 19723493 1:CAS:528:DC%2BD1MXhsVChtLnM
    • C Thomas A Gioiello L Noriega, et al. 2009 TGR5-mediated bile acid sensing controls glucose homeostasis Cell Metab 10 167 177 19723493 1:CAS:528:DC%2BD1MXhsVChtLnM
    • (2009) Cell Metab , vol.10 , pp. 167-177
    • Thomas, C.1    Gioiello, A.2    Noriega, L.3
  • 174
    • 73249142867 scopus 로고    scopus 로고
    • Discovery of 6α-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity
    • 20014870 1:CAS:528:DC%2BD1MXhsVSgtL%2FE
    • R Pellicciari A Gioiello A Macchiarulo, et al. 2009 Discovery of 6α-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity J Med Chem 52 7958 7961 20014870 1:CAS:528:DC%2BD1MXhsVSgtL%2FE
    • (2009) J Med Chem , vol.52 , pp. 7958-7961
    • Pellicciari, R.1    Gioiello, A.2    MacChiarulo, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.