Lipid exposure elicits differential responses in gene expression and DNA methylation in primary human skeletal muscle cells from severely obese women

Physiological Genomics

Volumn 47, Issue 5, 2015, Pages 139-146

  Maples, Jill M ^a,b   Brault, Jeffrey J ^c,d   Shewchuk, Brian M ^d   Witczak, Carol A ^c,d   Zou, Kai ^c   Rowland, Naomi ^b   Hubal, Monica J ^e   Weber, Todd M ^c   Houmard, Joseph A ^c  

^a WESTERN KENTUCKY UNIVERSITY   (United States)

^b WESTERN KENTUCKY UNIVERSITY   (United States)

^c EAST CAROLINA UNIVERSITY   (United States)

^d EAST CAROLINA UNIVERSITY   (United States)

^e CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

DNA methylation; Obesity; Skeletal muscle

Indexed keywords

DNA; GA BINDING PROTEIN; LIPID; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RNA; FATTY ACID; MESSENGER RNA; NUCLEAR RESPIRATORY FACTOR;

ADULT; ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; CPG ISLAND; DISEASE SEVERITY; DNA ISOLATION; DNA METHYLATION; FAT INTAKE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MUSCLE CELL; OBESITY; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; RNA ISOLATION; SKELETAL MUSCLE; TRANSCRIPTION INITIATION SITE; CELL CULTURE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; YOUNG ADULT;

ADULT; CELLS, CULTURED; DNA METHYLATION; FATTY ACIDS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LIPIDS; MUSCLE CELLS; MUSCLE, SKELETAL; NUCLEAR RESPIRATORY FACTORS; OBESITY; OXIDATION-REDUCTION; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; RNA, MESSENGER; YOUNG ADULT;

EID: 84930978656     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00065.2014     Document Type: Article

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