Ameliorative effects of monascus pilosus-fermented black soybean (Glycine max L. Merrill) on high-fat diet-induced obesity

Journal of Medicinal Food

Volumn 17, Issue 9, 2014, Pages 972-978

  Oh, Hong Geun ^a   Kang, Young Rye ^a   Lee, Hak Yong ^a   Kim, Jung Hoon ^a   Shin, Eun Hye ^a   Lee, Bong Gun ^a   Park, Sang Hoon ^a   Moon, Dae In ^a   Kim, Ok Jin ^b   Lee, In Ae ^c   Choi, Jongkeun ^d   Lee, Ji Ean ^c   Park, Kwang Hyun ^c,e   Suh, Joo Won ^c  

^a Huvet Co Ltd   (South Korea)

^b Wonkwang University   (South Korea)

^c Myong Ji University   (South Korea)

^d Chungwoon University   (South Korea)

^e Nambu University   (South Korea)

Author keywords

anti obesity effect; fermented black soybean; Glycine max L. Merrill; high fat diet induced obesity; hyperglycemia; Monascus pilosus

Indexed keywords

ANTILIPEMIC AGENT; ANTIOBESITY AGENT; CHOLESTEROL; GLUCOSE; HERBACEOUS AGENT; HYPOCHOLESTEROLEMIC AGENT; LEPTIN; PLACEBO; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; PLANT EXTRACT;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD GLUCOSE MONITORING; BODY WEIGHT; CELL SIZE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; EPIDIDYMIS FAT; EXPERIMENTAL OBESITY; FERMENTED BLACK SOYBEAN; FERMENTED PRODUCT; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; LIPID DIET; LIVER WEIGHT; MALE; MONASCUS PILOSUS; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; PERIRENAL FAT; RETROPERITONEAL FAT; SOYBEAN; TREATMENT RESPONSE; ADVERSE EFFECTS; ANIMAL; BLOOD; C57BL MOUSE; CYTOLOGY; DIET THERAPY; DRUG EFFECTS; FERMENTATION; LIVER; METABOLISM; MONASCUS; OBESITY; SOY FOOD; WEIGHT GAIN;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; ANTI-OBESITY AGENTS; BLOOD GLUCOSE; CHOLESTEROL; DIET, HIGH-FAT; DOSE-RESPONSE RELATIONSHIP, DRUG; FERMENTATION; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; LEPTIN; LIVER; MALE; MICE, INBRED C57BL; MONASCUS; OBESITY; PLANT EXTRACTS; SOY FOODS; SOYBEANS; WEIGHT GAIN;

EID: 84906987163     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2012.2740     Document Type: Article

References (55)

1. Liu KS: Chemistry and nurtitional value of soybean components. In: Soybean: Chemistry, Technology, and Utilization, (Keshun Liu, ed.). Chapman & Hall, New York, 1997, pp. 25-113.
2. Kunyanga CN, Imungi JK, Okoth M, Momanyi C, Biesalski HK, Vadivel V: Antioxidant and antidiabetic properties of condensed tannins in acetonic extract of selected raw and processed indigenous food ingredients from Kenya. J Food Sci 2011;76:C560-C567.
3. Itoh T, Hori Y, Atsumi T, Toriizuka K, Nakamura M, Maeyama T, Ando M, Tsukamasa Y, Ida Y, Furuichi Y: Hot water extract of adzuki (Vigna angularis) suppresses antigen-stimulated de-granulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. Phytother Res 2012;26:1003-1011.
4. Gundermann KJ, Kuenker A, Kuntz E, Droździk M: Activity of essential phospholipids (EPL) from soybean in liver diseases. Pharmacol Rep 2011;63:643-659.
5. Dixit AK, Antony JIX, Sharma NK, Tiwari RK: Soybean constituents and their functional benefits. Oppor Challenge Scope Nat Prod Med Chem 2011;367-383.
6. Sugano M, (ed.): Soy in Health and Disease Prevention. CRC Press, FL, 2006.
7. Choi YH, Lim H, Heo MY, Kwon DY, Kim HP: Anti-inflammatory activity of the ethanol extract of Chungkukjang, Korean fermented bean: 5-lipoxygenase inhibition. J Med Food 2008;11:539-543.
8. Yang X, Dong C, Ren G: Effect of soyasaponins-rich extract from soybean on acute alcohol-induced hepatotoxicity in mice. J Agric Food Chem 2011;59:1138-1144.
9. Van Horn L, McCoin M, Kris-Etherton PM, Burke F, Carson JA, Champagne CM, Karmally W, Sikand G: The evidence for dietary prevention and treatment of cardiovascular disease. J Am Diet Assoc 2008;108:287-331.
10. Taku K, Lin N, Cai D, Hu J, Zhao X, Zhang Y, Wang P, Melby MK, Hooper L, Kurzer MS, Mizuno S, Ishimi Y, Watanabe S: Effects of soy isoflavone extract supplements on blood pressure in adult humans: systematic review and meta-analysis of randomized placebo-controlled trials. J Hypertens 2010;28:1971-1982.
11. Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, D'Anna R, Corrado F, Pizzoleo MA, Cincotta M, Altavilla D, Ientile R, Squadrito FJ: Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomised double-blind placebo-controlled study. J Bone Min Res 2002;17:1904-1912.
12. Chen YM, Ho SC, Lam SSH, Ho SSS, Woo JLF: Soy iso-flavones have a favorable effect on bone loss in Chinese post-menopausal women with lower bone mass: a double-blind, randomized, controlled trial. J Clin Endocrinol Metab 2003;88: 4740-4747.
13. Cameron M, Gagnier JJ, Little CV, Parsons TJ, Blümle A, Chrubasik S: Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Part I: Osteoarthritis. Phyt-other Res 2009;23:1497-1515.
14. Holt S. Muntyan I, Likver L: Soya-based diets for diabetes mellitus. Altern Complement Ther 1996;2:79-82.
15. Ekor M, Emerole GO, Farombi EO: Phenolic extract of soybean (Glycine max) attenuates cisplatin-induced nephrotoxicity in rats. Food Chem Toxicol 2010;48:1005-1012.
16. Azcoitia I, Moreno A, Carrero P, Palacios S, Garcia-Segura LM: Neuroprotective effects of soy phytoestrogens in the rat brain. Gynecol Endocrinol 2006;22:63-69.
17. Kanamoto Y, Yamashita Y, Nanba F, Yoshida T, Tsuda T, Fu-kuda I, Nakamura-Tsuruta S, Ashida H: A black soybean seed coat extract prevents obesity and glucose intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed mice. J Agric Food Chem 2011;59:8985-8993.
18. Adlercreutz H, Mazur W, Bartels P, Elomaa VV, Watanabe S, Wahala K, Landstrom M, Lundin E, Bergh A, Damber JE, Aman P, Widmark A, Johansson A, Zhang JX, Hallmans GJ: Phy-toestrogens and prostate disease. J Nutr 2000;130:658-659.
19. Davies MJ, Bowey EA, Adlercreutz H, Rowland IA, Rumsby PC: Effects of soy or rye supplementation of high-fat diets on colon tumour development in azoxymethane treated rats. Car-cinogenesis 1999;20:927-931.
20. Klein DW, Lansing M. Harley J: Microbiology (6th ed.). McGraw-Hill, New York, 2006.
21. Shi YC, Pan TM: Beneficial effects of Monascus purpureus NTU 568-fermented products: a review. Appl Microbiol Biotechnol 2011;90:1207-1217.
22. Wild D, Toth G, Humpf HU: New Monascus metabolite isolated from red yeast rice (angkak, red koji). J Agric Food Chem 2002;50:3999-4002.
23. Juslova P, Martinkova L, Kren V: Secondary metabolites of the fungus Monascus: a review. J Ind Microbiol 1996;16:163-170.
24. Ma J, Li Y, Ye Q, Li J, Hua Y, Ju D, Zhang D, Cooper R, Chang M: Constituents of red yeast rice, a traditional Chinese food and medicine. J Agric Food Chem 2000;48:5220-5225.
25. Lee CL, Tsai TY, Wang JJ, Pan TM: In vivo hypolipidemic effects and safety of low dosage Monascus powder in a hamster model of hyperlipidemia. Appl Microbiol Biotechnol 2006;70:533-540.
26. Chen CC, Liu IM: Release of acetylcholine by Hon-Chi to raise insulin secretion in Wistar rats. Neurosci Lett 2008;404:117-121.
27. Kohama Y, Matsumoto S, Mimura T, Tanabe N, Inada A, Na-kanishi T: Isolation and identification of hypotensive principles in red-mold rice. Chem Pharm Bull (Tokyo) 1987;35:2484-2489.
28. Singewald N, Kouvelas D, Mostafa A, Sinner C, Philippu A: Release of glutamate and GABA in the amygdala of conscious rats by acute stress and baroreceptor activation: differences between SHR and WKY rats. Brain Res 2000;864:138-141.
29. Ho BY, Pan TM: The Monascus metabolite monacolin K reduces tumor progression and metastasis of Lewis lung carcinoma cells. J Agric Food Chem 2009;57:8258-8265.
30. Lee CL, Kuo TF, Wang JJ, Pan TM: Red mold rice ameliorates impairment of memory and learning ability in intracerebro-ventricular amyloid beta-infused rat by repressing amyloid beta accumulation. J Neurosci Res 2007;85:3171-3182.
31. Lee CL, Wang JJ, Pan TM: Red mold rice extract represses amyloid beta peptide-induced neurotoxicity via potent synergism of anti-inflammatory and antioxidative effect. Appl Microbiol Biotechnol 2008;79:829-841.
32. Jeon T, Hwang SG, Hirai S, Matsui T, Yano H, Kawada T, Lim BO, Park DK: Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells. Life Sci 2004;75:3195-3203.
33. Chen WP, Ho BY, Lee CL, Lee CH, Pan TM: Red mold rice prevents the development of obesity, dyslipidemia and hyper-insulinemia induced by high-fat diet. Int J Obes (Lond) 2008;32:1694-1704.
34. Wei Y, Chen K, Whaley-Connell AT, Stump CS, Ibdah JA, et al.: Skeletal muscle insulin resistance: role of inflammatory cy-tokines and reactive oxygen species. Am J Physiol Regul Integr Comp Physiol 2008;294:673-680.
35. Hotamisligil GS: Inflammation and metabolic disorders. Nature 2006;444: 860-867.
36. Cancello R, Clement K: Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG 2006;113:1141-1147.
37. Lumeng CN, Bodzin JL, Saltiel AR: Obesity induces a pheno-typic switch in adipose tissue macrophage polarization. J Clin Invest 2007;117:175-184.
38. Lo CW, Huang HP, Lin HM, Chien CT, Wang CJ: Effect of hibiscus anthocyanins-rich extract induces apoptosis of proliferating smooth muscle cell via activation of P38 MAPK and p53 pathway. Mol Nutr Food Res 2007;51:1452-1460.
39. Nizamutdinova IT, Jin YC, Chung JI, Shin SC, Lee SJ, et al.: The anti-diabetic effect of anthocyanins in streptozotocininduced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis. Mol Nutr Food Res 2009;53:1419-1429.
40. Nassiri-Asl M, Hosseinzadeh H: Review of the pharmacological effects of Vitis vinifera (grape) and its bioactive compounds. Phytother Res 2009;23:1197-1204.
41. Todd JJ, Vodkin LO: Pigmented soybean (Glycine max) seed coats accumulate proanthocyanidins during development. Plant Physiol 1993;102:663-670.
42. Choung MG, Baek IY, Kang ST, Han WY, Shin DC, Moon HP, Kang KH: Isolation and determination of anthocyanins in seed coats of black soybean (Glycine max (L.) Merr.). J Agric Food Chem 2001;49:5848-5851.
43. Spiegelman BM, Flier JS: Adipogenesis and obesity: rounding out the big picture. Cell 1996;87:377-389.
44. Mandrup S, Lane MD: Regulating adipogenesis. J Biol Chem 1997;272:5367-5370.
45. McNamara JR, Cohn JS, Wilson PW, Schaefer EJ: Calculated values for low-density lipoprotein cholesterol in the assessment of lipid abnormalities and coronary disease risk. Clin Chem 1990;36:36-42.
46. Remesar X, Fernandez-Lopez JA, Blay MT, Savall P, Salas A, Dáiz-Silva M, Esteve M, Grasa MM, Alemany M: Effect of oral oleoyl-estrone on adipose tissue composition in male rats. Int J Obes Relat Metab Disord 2002;26:1092-1102.
47. Laye MJ, Thyfault JP, Stump CS, Booth FW: Inactivity induces increases in abdominal fat. J Appl Physiol 2007;102:1341-1347.
48. Kim J, Kyung J, Kim D, Choi EK, Bang P, Park D, Kim YB: Anti-obesity effects of Rapha diet® preparation in mice fed a high-fat diet. Lab Anim Res 2012;28:265-271.
49. Bennett JW, Klich M: Mycotoxins. Clin Microbiol Rev 2003;16:497-516.
50. Lee JH, Jun HJ, Jia Y, Kim W, Choi SG, Lee SJ: Critical role of peroxisome proliferator activated receptor-<5 on body fat reduction in C57BL/6J and human apolipoprotein E2 transgenic mice fed delipidated soybean. J Agric Food Chem 2011;59:11872-11881.
51. Carrara VS, Amato AA, Neves FA, Bazotte RB, Mandarino JM, Nakamura CV, Filho BP, Cortez DA: Effects of a methanolic fraction of soybean seeds on the transcriptional activity of peroxisome proliferator-activated receptors (PPAR). Braz J Med Biol Res 2009;42:545-550.
52. Noriega-Lopez L, Tovar AR, Gonzalez-Granillo M, Hernandez-Pando R, Escalante B, Santillan-Doherty P, Torres N: Pancreatic insulin secretion in rats fed a soy protein high fat diet depends on the interaction between the amino acid pattern and isoflavones. J Biol Chem 2007;282:20657-20666.
53. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J: Transient increase in obese gene expression after food intake or insulin administration. Nature 1995;377:527-529.
54. Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P, Guy-Grand B: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401.
55. Davaatseren M, Hur HJ, Yang HJ, Hwang JT, Park JH, Kim HJ, Kim MJ, Kwon DY, Sung MJ: Taraxacum official (dandelion) leaf extract alleviates high-fat diet-induced nonalcoholic fatty liver. Food Chem Toxicol 2013;58:30-36.