Fat burners: Nutrition supplements that increase fat metabolism

Obesity Reviews

Volumn 12, Issue 10, 2011, Pages 841-851

  Jeukendrup, A E ^a   Randell, R ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Caffeine; Carnitine; Conjugated linoleic acid; Forskolin; Green tea; Taurine

Indexed keywords

CAFFEINE; CARNITINE; CHROMIUM; CONJUGATED LINOLEIC ACID; FORSKOLIN; FUCOXANTHIN; TAURINE;

ADAPTATION; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; DIET SUPPLEMENTATION; ENERGY EXPENDITURE; EXERCISE; FATTY ACID OXIDATION; HUMAN; KELP; LIPID ABSORPTION; LIPID METABOLISM; NONHUMAN; OBESITY; TEA; WEIGHT REDUCTION;

CAFFEINE; CARNITINE; CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMIUM; DIETARY SUPPLEMENTS; FORSKOLIN; HUMANS; KELP; LINOLEIC ACIDS, CONJUGATED; LIPID METABOLISM; TAURINE; TEA; TRACE ELEMENTS; VITAMIN B COMPLEX; XANTHOPHYLLS;

EID: 80053152296     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/j.1467-789X.2011.00908.x     Document Type: Article

References (82)

1. Costill DL, Dalsky GP, Fink WJ. Effects of caffeine ingestion on metabolism and exercise performance. Med Sci Sports Exerc 1978; 10: 155-158.
2. Essig D, Costill DL, Van Handel PJ. Effects of caffeine ingestion on utilization of muscle glycogen and lipid during leg ergometer cycling. Int J Sports Med 1980; 1: 86-90.
3. Leijten PA, van Breemen C. The effects of caffeine on the noradrenaline-sensitive calcium store in rabbit aorta. J Physiol 1984; 357: 327-339.
4. Acheson KJ, Zahorska-Markiewicz B, Pittet P, Anantharaman K, Jequier E. Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals. Am J Clin Nutr 1980; 33: 989-997.
5. Dulloo AG, Geissler CA, Horton T, Collins A, Miller DS. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. Am J Clin Nutr 1989; 49: 44-50.
6. Hollands MA, Arch JR, Cawthorne MA. A simple apparatus for comparative measurements of energy expenditure in human subjects: the thermic effect of caffeine. Am J Clin Nutr 1981; 34: 2291-2294.
7. Astrup A, Toubro S, Cannon S, Hein P, Breum L, Madsen J. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am J Clin Nutr 1990; 51: 759-767.
8. Astrup A, Buemann B, Christensen NJ, Toubro S, Thorbek G, Victor OJ etal. The effect of ephedrine/caffeine mixture on energy expenditure and body composition in obese women. Metabolism 1992; 41: 686-688.
9. Boozer CN, Daly PA, Homel P, Solomon JL, Blanchard D, Nasser JA etal. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. Int J Obes Relat Metab Disord 2002; 26: 593-604.
10. Westerterp-Plantenga MS, Lejeune MP, Kovacs EM. Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obes Res 2005; 13: 1195-1204.
11. Graham TE, Battram DS, Dela F, El-Sohemy A, Thong FS. Does caffeine alter muscle carbohydrate and fat metabolism during exercise? Appl Physiol Nutr Metab 2008; 33: 1311-1318.
12. Bremer J. Carnitine - metabolism and functions. Physiol Rev 1983; 63: 1420-1479.
13. Constantin-Teodosiu D, Carlin JI, Cederblad G, Harris RC, Hultman E. Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise. Acta Physiol Scand 1991; 143: 367-372.
14. Timmons JA, Poucher SM, Constantin-Teodosiu D, Worrall V, Macdonald IA, Greenhaff PL. Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia. J Clin Invest 1996; 97: 879-883.
15. Barnett C, Costill DL, Vukovich MD, Cole KJ, Goodpaster BH, Trappe SW etal. Effect of L-carnitine supplementation on muscle and blood carnitine content and lactate accumulation during high-intensity sprint cycling. Int J Sport Nutr 1994; 4: 280-288.
16. Vukovich MD, Costill DL, Fink WJ. Carnitine supplementation: effect on muscle carnitine and glycogen content during exercise. J Appl Physiol 1994; 26: 1122-1129.
17. Wagenmakers AJM. Nutritional Supplements: Effects on Exercise Performance and Metabolism. Lamb DR, Murray R (eds). Cooper Publishing Group: Carmel, IN, 1999.
18. Stephens FB, Constantin-Teodosiu D, New GPL. insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. J Physiol 2007; 581: 431-444.
19. Stephens FB, Constantin-Teodosiu D, Laithwaite D, Simpson EJ, Greenhaff PL. Insulin stimulates L-carnitine accumulation in human skeletal muscle. FASEB J 2006; 20: 377-379.
20. Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL. Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans: the dual role of muscle carnitine in exercise metabolism. J Physiol 2011; 589: 963-973.
21. Litosch I, Hudson TH, Mills I, Li SY, Fain JN. Forskolin as an activator of cyclic AMP accumulation and lipolysis in rat adipocytes. Mol Pharmacol 1982; 22: 109-115.
22. Ho R, Shi QH. Forskolin as a novel lipolytic agent. Biochem Biophys Res Commun 1982; 107: 157-164.
23. Godard MP, Johnson BA, Richmond SR. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes Res 2005; 13: 1335-1343.
24. Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun 2005; 332: 392-397.
25. Maeda H, Hosokawa M, Sashima T, Takahashi N, Kawada T, Miyashita K. Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int J Mol Med 2006; 18: 147-152.
26. Abidov M, Ramazanov Z, Seifulla R, Grachev S. The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat. Diabetes Obes Metab 2010; 12: 72-81.
27. Borchardt RT, Huber JA. Catechol O-methyltransferase. 5. Structure-activity relationships for inhibition by flavonoids. J Med Chem 1975; 18: 120-122.
28. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M etal. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 1999; 70: 1040-1045.
29. Rumpler W, Seale J, Clevidence B, Judd J, Wiley E, Yamamoto S etal. Oolong tea increases metabolic rate and fat oxidation in men. J Nutr 2001; 131: 2848-2852.
30. Berube-Parent S, Pelletier C, Dore J, Tremblay A. Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24h energy expenditure and fat oxidation in men. Br J Nutr 2005; 94: 432-436.
31. Gregersen NT, Bitz C, Krog-Mikkelsen I, Hels O, Kovacs EM, Rycroft JA etal. Effect of moderate intakes of different tea catechins and caffeine on acute measures of energy metabolism under sedentary conditions. Br J Nutr 2009; 102: 1187-1194.
32. Hursel R, Viechtbauer W, Dulloo AG, Tremblay A, Tappy L, Rumpler W etal. The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis. Obes Rev 2011; 12: e573-e581.
33. Harada U, Chikama A, Saito S, Takase H, Nagao T, Hase T etal. Effects of the long term ingestion of tea catechins on energy expenditure and dietary fat oxidation in healthy subjects. J Health Sci 2005; 51: 248-252.
34. Auvichayapat P, Prapochanung M, Tunkamnerdthai O, Sripanidkulchai BO, Auvichayapat N, Thinkhamrop B etal. Effectiveness of green tea on weight reduction in obese Thais: a randomized, controlled trial. Physiol Behav 2008; 93: 486-491.
35. Chantre P, Lairon D. Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity. Phytomedicine 2002; 9: 3-8.
36. Nagao T, Hase T, Tokimitsu I. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity (Silver Spring) 2007; 15: 1473-1483.
37. Hill AM, Coates AM, Buckley JD, Ross R, Thielecke F, Howe PR. Can EGCG reduce abdominal fat in obese subjects? J Am Coll Nutr 2007; 26: 396S-402S.
38. Nagao T, Komine Y, Soga S, Meguro S, Hase T, Tanaka Y etal. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J Clin Nutr 2005; 81: 122-129.
39. Wang H, Wen Y, Du Y, Yan X, Guo H, Rycroft JA etal. Effects of catechin enriched green tea on body composition. Obesity (Silver Spring) 2010; 18: 773-779.
40. Diepvens K, Kovacs EM, Nijs IM, Vogels N, Westerterp-Plantenga MS. Effect of green tea on resting energy expenditure and substrate oxidation during weight loss in overweight females. Br J Nutr 2005; 94: 1026-1034.
41. Di Pierro F, Menghi AB, Barreca A, Lucarelli M, Calandrelli A. Greenselect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Altern Med Rev 2009; 14: 154-160.
42. Hursel R, Viechtbauer W, Westerterp-Plantenga MS. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes (Lond) 2009; 33: 956-961.
43. Lee MS, Kim CT, Kim Y. Green tea (-)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice. Ann Nutr Metab 2009; 54: 151-157.
44. Chen N, Bezzina R, Hinch E, Lewandowski PA, Cameron-Smith D, Mathai ML etal. Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. Nutr Res 2009; 29: 784-793.
45. Kim HJ, Jeon SM, Lee MK, Jung UJ, Shin SK, Choi MS. Antilipogenic effect of green tea extract in C57BL/6J-Lep ob/ob mice. Phytother Res 2009; 23: 467-471.
46. Achten J, Gleeson M, Jeukendrup AE. Determination of the exercise intensity that elicits maximal fat oxidation. Med Sci Sports Exerc 2002; 34: 92-97.
47. Achten J, Jeukendrup AE. Maximal fat oxidation during exercise in trained men. Int J Sports Med 2003; 24: 603-608.
48. Shimotoyodome A, Haramizu S, Inaba M, Murase T, Tokimitsu I. Exercise and green tea extract stimulate fat oxidation and prevent obesity in mice. Med Sci Sports Exerc 2005; 37: 1884-1892.
49. Murase T, Haramizu S, Shimotoyodome A, Nagasawa A, Tokimitsu I. Green tea extract improves endurance capacity and increases muscle lipid oxidation in mice. Am J Physiol Regul Integr Comp Physiol 2005; 288: R708-R715.
50. Murase T, Haramizu S, Shimotoyodome A, Tokimitsu I, Hase T. Green tea extract improves running endurance in mice by stimulating lipid utilization during exercise. Am J Physiol Regul Integr Comp Physiol 2006; 290: R1550-R1556.
51. Venables MC, Hulston CJ, Cox HR, Jeukendrup AE. Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am J Clin Nutr 2008; 87: 778-784.
52. Ota N, Soga S, Shimotoyodome A, Haramizu S, Inaba M, Murase T etal. Effects of combination of regular exercise and tea catechins intake on energy expenditure in humans. J Health Sci 2005; 51: 233-236.
53. Eichenberger P, Colombani PC, Mettler S. Effects of 3-week consumption of green tea extracts on whole-body metabolism during cycling exercise in endurance-trained men. Int J Vitam Nutr Res 2009; 79: 24-33.
54. Ichinose T, Nomura S, Someya Y, Akimoto S, Tachiyashiki K, Imaizumi K. Effect of endurance training supplemented with green tea extract on substrate metabolism during exercise in humans. Scand J Med Sci Sports 2010; 21: 598-605.
55. NAoSIo (ed.). Dietary Reference Intakes: Recommended Intakes for Individuals Medicine. The National Academies Press: Washington, D.C., 2005.
56. Anderson RA, Kozlovsky AS. Chromium intake, absorption and excretion of subjects consuming self-selected diets. Am J Clin Nutr 1985; 41: 1177-1183.
57. Evans GW. The effect of chromium picolinate on insulin controlled parameters in humans. Int J Biosoc Med Res 1989; 11: 163-180.
58. Clancy SP, Clarkson PM, DeCheke ME, Nosaka K, Freedson PS, Cunningham JJ etal. Effects of chromium picolinate supplementation on body composition, strength, and urinary chromium loss in football players. Int J Sport Nutr 1994; 4: 142-153.
59. Hallmark MA, Reynolds TH, DeSouza CA, Dotson CO, Anderson RA, Rogers MA. Effects of chromium and resistive training on muscle strength and body composition. Med Sci Sports Exerc 1996; 28: 139-144.
60. Hasten DL, Morris GS, Ramanadham S, Yarasheski KE. Isolation of human skeletal muscle myosin heavy chain and actin for measurement of fractional synthesis rates. Am J Physiol 1998; 275: E1092-E1099.
61. Lukaski HC, Bolonchuk WW, Siders WA, Milne DB. Chromium supplementation and resistance training: effects on body composition, strength, and trace element status of men (see comments). Am J Clin Nutr 1996; 63: 954-965.
62. Lukaski HC, Siders WA, Penland JG. Chromium picolinate supplementation in women: effects on body weight, composition, and iron status. Nutrition 2007; 23: 187-195.
63. Stearns DM, Belbruno JJ, Wetterhahn KE. A prediction of chromium(III) accumulation in humans from chromium dietary supplements. FASEB J 1995; 9: 1650-1657.
64. McCarty MF. Chromium(III) picolinate (letter). FASEB J 1996; 10: 365-369.
65. Park Y, Albright KJ, Liu W, Storkson JM, Cook ME, Pariza MW. Effect of conjugated linoleic acid on body composition in mice. Lipids 1997; 32: 853-858.
66. Rahman SM, Wang Y, Yotsumoto H, Cha J, Han S, Inoue S etal. Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats. Nutrition 2001; 17: 385-390.
67. Houseknecht KL, Vanden Heuvel JP, Moya-Camarena SY, Portocarrero CP, Peck LW, Nickel KP etal. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun 1998; 244: 678-682.
68. Malpuech-Brugère C, Verboeket WP, Mensink RP, Arnal MA, Morio B, Brandolini M etal. Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obes Res 2004; 12: 591-598.
69. Gaullier JM, Halse J, Hoivik HO, Hoye K, Syvertsen C, Nurminiemi M etal. Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese. Br J Nutr 2007; 97: 550-560.
70. Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H etal. Conjugated linoleic acid supplementation for 1 year reduces body fat mass in healthy overweight humans. Am J Clin Nutr 2004; 79: 1118-1125.
71. Whigham LD, Watras AC, Schoeller DA. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr 2007; 85: 1203-1211.
72. Park Y, Albright KJ, Storkson JM, Liu W, Cook ME, Pariza MW. Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 1999; 34: 243-248.
73. West DB, Blohm FY, Truett AA, DeLany JP. Conjugated linoleic acid persistently increases total energy expenditure in AKR/J mice without increasing uncoupling protein gene expression. J Nutr 2000; 130: 2471-2477.
74. Ryder JW, Portocarrero CP, Song XM, Cui L, Yu M, Combatsiaris T etal. Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. Diabetes 2001; 50: 1149-1157.
75. Belury MA, Mahon A, Banni S. The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. J Nutr 2003; 133: 257S-260S.
76. Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 2000; 130: 2943-2948.
77. Smedman A, Vessby B. Conjugated linoleic acid supplementation in humans - metabolic effects. Lipids 2001; 36: 773-781.
78. Riserus U, Vessby B, Arnlov J, Basu S. Effects of cis-9, trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr 2004; 80: 279-283.
79. Riserus U, Vessby B, Arner P, Zethelius B. Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia 2004; 47: 1016-1019.
80. Rutherford JA, Spriet LL, Stellingwerff T. The effect of acute taurine ingestion on endurance performance and metabolism in well-trained cyclists. Int J Sport Nutr Exerc Metab 2010; 20: 322-329.
81. Galloway SD, Talanian JL, Shoveller AK, Heigenhauser GJ, Spriet LL. Seven days of oral taurine supplementation does not increase muscle taurine content or alter substrate metabolism during prolonged exercise in humans. J Appl Physiol 2008; 105: 643-651.
82. Jester I, Grigereit A, Bernhardt M, Heil S, Banzer W. Effects of ingesting a taurine-enriched, caffeine containing drink on performance and haemodynamics in acyclic trained athletes. Amino Acids 1997; 13: 72-73.