Soy, phytoestrogens and metabolism: A review

Molecular and Cellular Endocrinology

Volumn 304, Issue 1-2, 2009, Pages 30-42

  Cederroth, Christopher R ^a   Nef, Serge ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Dietary soy; Endocrine disruptor; Genistein; Glycemia; Isoflavones; Obesity; Phytoestrogens

Indexed keywords

CONJUGATED ESTROGEN; ESTRADIOL; GENISTEIN; GLUCOSE; ISOFLAVONE; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOESTROGEN; SOYBEAN PROTEIN; TRIACYLGLYCEROL;

ABSORPTION; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; DIET SUPPLEMENTATION; DRUG EFFECT; FOOD COMPOSITION; FOOD INTAKE; GLUCOSE METABOLISM; GLYCEMIC CONTROL; HUMAN; INGESTION; LIPID METABOLISM; METABOLIC DISORDER; METABOLISM; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; SOYBEAN; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION;

ANIMALS; DIABETES MELLITUS, TYPE 2; DIET; DIETARY SUPPLEMENTS; GLUCOSE; HUMANS; ISOFLAVONES; LIPID METABOLISM; MOLECULAR STRUCTURE; OBESITY; PHYTOESTROGENS; PLANT PROTEINS; SOY FOODS;

EID: 67349280310     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2009.02.027     Document Type: Review

References (143)

1. Adachi T., Yasuda K., Mori C., Yashinaga M., Aoki N., Tsujimoto G., and Tsuda K. Promoting insulin secretion in pancreatic islets by means of bisphenol-A and nonylphenol via intracellular estrogen-receptors. Food Chem. Toxicol. 43 (2005) 713-719
2. Adlercreutz H., Fotsis T., Lampe J., Wahala K., Makela T., Brunow G., and Hase T. Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chromatography-mass spectrometry. Scand. J. Clin. Lab. Invest. 215 Suppl. (1993) 5-18
3. Adlercreutz H., Markkanen H., and Watanabe S. Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 342 (1993) 1209-1210
4. Ae Park S., Choi M.S., Cho S.Y., Seo J.S., Jung U.J., Kim M.J., Sung M.K., Park Y.B., and Lee M.K. Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice. Life Sci. 79 (2006) 1207-1213
5. Ahmed-Sorour H., and Bailey C.J. Role of ovarian hormones in the long-term control of glucose homeostasis. Interaction with insulin, glucagon and epinephrine. Horm. Res. 13 (1980) 396-403
6. Akiyama T., Ishida J., Nakagawa S., Ogawara H., Watanabe S., Itoh N., Shibuya M., and Fukami Y. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262 (1987) 5592-5595
7. Ali A.A., Velasquez M.T., Hansen C.T., Mohamed A.I., and Bhathena S.J. Modulation of carbohydrate metabolism and peptide hormones by soybean isoflavones and probiotics in obesity and diabetes. J. Nutr. Biochem. 16 (2005) 693-699
8. Allison D.B., Gadbury G., Schwartz L.G., Murugesan R., Kraker J.L., Heshka S., Fontaine K.R., and Heymsfield S.B. A novel soy-based meal replacement formula for weight loss among obese individuals: a randomized controlled clinical trial. Eur. J. Clin. Nutr. 57 (2003) 514-522
9. Alonso-Magdalena P., Morimoto S., Ripoll C., Fuentes E., and Nadal A. The estrogenic effect of bisphenol A disrupts pancreatic beta-cell function in vivo and induces insulin resistance. Environ. Health Perspect. 114 (2006) 106-112
10. Alonso-Magdalena P., Ropero A.B., Carrera M.P., Cederroth C.R., Baquie M., Gauthier B.R., Nef S., Stefani E., and Nadal A. Pancreatic insulin content regulation by the estrogen receptor ER alpha. PLoS ONE 3 (2008) e2069
11. Anderson J.W., Johnstone B.M., and Cook-Newell M.E. Meta-analysis of the effects of soy protein intake on serum lipids. N. Engl. J. Med. 333 (1995) 276-282
12. Anderson J.W., and Hoie L.H. Weight loss and lipid changes with low-energy diets: comparator study of milk-based versus soy-based liquid meal replacement interventions. J. Am. Coll. Nutr. 24 (2005) 210-216
13. Anderson J.W., Fuller J., Patterson K., Blair R., and Tabor A. Soy compared to casein meal replacement shakes with energy-restricted diets for obese women: randomized controlled trial. Metabolism 56 (2007) 280-288
14. Aoyama T., Fukui K., Nakamori T., Hashimoto Y., Yamamoto T., Takamatsu K., and Sugano M. Effect of soy and milk whey protein isolates and their hydrolysates on weight reduction in genetically obese mice. Biosci. Biotechnol. Biochem. 64 (2000) 2594-2600
15. Aoyama T., Fukui K., Takamatsu K., Hashimoto Y., and Yamamoto T. Soy protein isolate and its hydrolysate reduce body fat of dietary obese rats and genetically obese mice (yellow KK). Nutrition 16 (2000) 349-354
16. Atkinson C., Frankenfeld C.L., and Lampe J.W. Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health. Exp. Biol. Med. (Maywood) 230 (2005) 155-170
17. Bailey C.J., and Matty A.J. Glucose tolerance and plasma insulin of the rat in relation to the oestrous cycle and sex hormones. Horm. Metab. Res. 4 (1972) 266-270
18. Bailey C.J., and Ahmed-Sorour H. Role of ovarian hormones in the long-term control of glucose homeostasis. Effects of insulin secretion. Diabetologia 19 (1980) 475-481
19. Barros R.P., Machado U.F., Warner M., and Gustafsson J.A. Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 1605-1608
20. Bates S.H., and Myers Jr. M.G. The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol. Metab. 14 (2003) 447-452
21. Bennetts H.W., Underwood E.J., and Shier F.L. A specific breeding problem of sheep on subterranean clover pastures in Western Australia. Austr. Vet. J. 22 (1946) 2-12
22. Bhathena S.J., and Velasquez M.T. Beneficial role of dietary phytoestrogens in obesity and diabetes. Am. J. Clin. Nutr. 76 (2002) 1191-1201
23. Bu L., Setchell K.D., and Lephart E.D. Influences of dietary soy isoflavones on metabolism but not nociception and stress hormone responses in ovariectomized female rats. Reprod. Biol. Endocrinol. 3 (2005) 58
24. Bu L.H., and Lephart E.D. Effects of dietary phytoestrogens on core body temperature during the estrous cycle and pregnancy. Brain Res. Bull. 65 (2005) 219-223
25. Caldwell C.R., Britz S.J., and Mirecki R.M. Effect of temperature, elevated carbon dioxide, and drought during seed development on the isoflavone content of dwarf soybean [Glycine max (L.) Merrill] grown in controlled environments. J. Agric. Food Chem. 53 (2005) 1125-1129
26. Carani C., Qin K., Simoni M., Faustini-Fustini M., Serpente S., Boyd J., Korach K.S., and Simpson E.R. Effect of testosterone and estradiol in a man with aromatase deficiency. N. Engl. J. Med. 337 (1997) 91-95
27. Case A.M., and Reid R.L. Menstrual cycle effects on common medical conditions. Compr. Ther. 27 (2001) 65-71
28. Cederroth C.R., Vinciguerra M., Kuhne F., Madani R., Doerge D.R., Visser T.J., Foti M., Rohner-Jeanrenaud F., Vassalli J.D., and Nef S. A phytoestrogen-rich diet increases energy expenditure and decreases adiposity in mice. Environ. Health Perspect. 115 (2007) 1467-1473
29. Cederroth C.R., Vinciguerra M., Gjinovci A., Kuhne F., Klein M., Cederroth M., Caille D., Suter M., Neumann D., James R.W., Doerge D.R., Wallimann T., Meda P., Foti M., Rohner-Jeanrenaud F., Vassalli J.D., and Nef S. Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism. Diabetes 57 (2008) 1176-1185
30. Chen A.C., and Donovan S.M. Genistein at a concentration present in soy infant formula inhibits Caco-2BBe cell proliferation by causing G2/M cell cycle arrest. J. Nutr. 134 (2004) 1303-1308
31. Cheng S.Y., Shaw N.S., Tsai K.S., and Chen C.Y. The hypoglycemic effects of soy isoflavones on postmenopausal women. J. Women Health (Larchmt) 13 (2004) 1080-1086
32. Choi M.S., Jung U.J., Yeo J., Kim M.J., and Lee M.K. Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice. Diabetes Metab. Res. Rev. 24 (2008) 74-81
33. Cooke P.S., Heine P.A., Taylor J.A., and Lubahn D.B. The role of estrogen and estrogen receptor-alpha in male adipose tissue. Mol. Cell. Endocrinol. 178 (2001) 147-154
34. Cooke P.S., and Naaz A. Role of estrogens in adipocyte development and function. Exp. Biol. Med. (Maywood) 229 (2004) 1127-1135
35. Coward L., Kirk M., Albin N., and Barnes S. Analysis of plasma isoflavones by reversed-phase HPLC-multiple reaction ion monitoring-mass spectrometry. Clin. Chim. Acta 247 (1996) 121-142
36. Crouse III J.R., Morgan T., Terry J.G., Ellis J., Vitolins M., and Burke G.L. A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch. Intern. Med. 159 (1999) 2070-2076
37. Dalais F.S., Ebeling P.R., Kotsopoulos D., McGrath B.P., and Teede H.J. The effects of soy protein containing isoflavones on lipids and indices of bone resorption in postmenopausal women. Clin. Endocrinol. (Oxf.) 58 (2003) 704-709
38. Davis J., Iqbal M.J., Steinle J., Oitker J., Higginbotham D.A., Peterson R.G., and Banz W.J. Soy protein influences the development of the metabolic syndrome in male obese ZDFxSHHF rats. Horm. Metab. Res. 37 (2005) 316-325
39. de Kleijn M.J., van der Schouw Y.T., Wilson P.W., Grobbee D.E., and Jacques P.F. Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S. women: the Framingham study. J. Nutr. 132 (2002) 276-282
40. Dixon R.A. Phytoestrogens. Annu. Rev. Plant Biol. 55 (2004) 225-261
41. Dolinoy D.C., Weidman J.R., Waterland R.A., and Jirtle R.L. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ. Health Perspect. 114 (2006) 567-572
42. Duffy C., Perez K., and Partridge A. Implications of phytoestrogen intake for breast cancer. CA Cancer J. Clin. 57 (2007) 260-277
43. Engelgau M.M., Geiss L.S., Saaddine J.B., Boyle J.P., Benjamin S.M., Gregg E.W., Tierney E.F., Rios-Burrows N., Mokdad A.H., Ford E.S., Imperatore G., and Narayan K.M. The evolving diabetes burden in the United States. Ann. Intern. Med. 140 (2004) 945-950
44. Foryst-Ludwig A., Clemenz M., Hohmann S., Hartge M., Sprang C., Frost N., Krikov M., Bhanot S., Barros R., Morani A., Gustafsson J.A., Unger T., and Kintscher U. Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma. PLoS Genet. 4 (2008) e1000108
45. Fujimoto W.Y., Leonetti D.L., Kinyoun J.L., Newell-Morris L., Shuman W.P., Stolov W.C., and Wahl P.W. Prevalence of diabetes mellitus and impaired glucose tolerance among second-generation Japanese-American men. Diabetes 36 (1987) 721-729
46. Fujimoto W.Y., Leonetti D.L., Bergstrom R.W., Kinyoun J.L., Stolov W.C., and Wahl P.W. Glucose intolerance and diabetic complications among Japanese-American women. Diabetes Res. Clin. Pract. 13 (1991) 119-129
47. Gambacciani M., Ciaponi M., Cappagli B., Piaggesi L., De Simone L., Orlandi R., and Genazzani A.R. Body weight, body fat distribution, and hormonal replacement therapy in early postmenopausal women. J. Clin. Endocrinol. Metab. 82 (1997) 414-417
48. Gao Q., Mezei G., Nie Y., Rao Y., Choi C.S., Bechmann I., Leranth C., Toran-Allerand D., Priest C.A., Roberts J.L., Gao X.B., Mobbs C., Shulman G.I., Diano S., and Horvath T.L. Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nat. Med. 13 (2007) 89-94
49. Garcia M.C., Torre M., Marina M.L., and Laborda F. Composition and characterization of soyabean and related products. Crit. Rev. Food Sci. Nutr. 37 (1997) 361-391
50. Gardner C.D., Newell K.A., Cherin R., and Haskell W.L. The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. Am. J. Clin. Nutr. 73 (2001) 728-735
51. Godsland I.F. Oestrogens and insulin secretion. Diabetologia 48 (2005) 2213-2220
52. Goodman-Gruen D., and Kritz-Silverstein D. Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women. J. Nutr. 131 (2001) 1202-1206
53. Goodman-Gruen D., and Kritz-Silverstein D. Usual dietary isoflavone intake and body composition in postmenopausal women. Menopause 10 (2003) 427-432
54. Greany K.A., Nettleton J.A., Wangen K.E., Thomas W., and Kurzer M.S. Probiotic consumption does not enhance the cholesterol-lowering effect of soy in postmenopausal women. J. Nutr. 134 (2004) 3277-3283
55. Grieshop C.M., and Fahey Jr. G.C. Comparison of quality characteristics of soybeans from Brazil, China, and the United States. J. Agric. Food Chem. 49 (2001) 2669-2673
56. Grieshop C.M., Kadzere C.T., Clapper G.M., Flickinger E.A., Bauer L.L., Frazier R.L., and Fahey Jr. G.C. Chemical and nutritional characteristics of United States soybeans and soybean meals. J. Agric. Food Chem. 51 (2003) 7684-7691
57. Guthrie J.R., Ball M., Murkies A., and Dennerstein L. Dietary phytoestrogen intake in mid-life Australian-born women: relationship to health variables. Climacteric 3 (2000) 254-261
58. Hall W.L., Vafeiadou K., Hallund J., Bugel S., Reimann M., Koebnick C., Zunft H.J., Ferrari M., Branca F., Dadd T., Talbot D., Powell J., Minihane A.M., Cassidy A., Nilsson M., Dahlman-Wright K., Gustafsson J.A., and Williams C.M. Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: interactions with genotype and equol production. Am. J. Clin. Nutr. 83 (2006) 592-600
59. Heine P.A., Taylor J.A., Iwamoto G.A., Lubahn D.B., and Cooke P.S. Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 12729-12734
60. Howitz K.T., and Sinclair D.A. Xenohormesis: sensing the chemical cues of other species. Cell 133 (2008) 387-391
61. Hurley C., Richard D., Deshaies Y., and Jacques H. Soy protein isolate in the presence of cornstarch reduces body fat gain in rats. Can. J. Physiol. Pharmacol. 76 (1998) 1000-1007
62. Hwang C.S., Kwak H.S., Lim H.J., Lee S.H., Kang Y.S., Choe T.B., Hur H.G., and Han K.O. Isoflavone metabolites and their in vitro dual functions: they can act as an estrogenic agonist or antagonist depending on the estrogen concentration. J. Steroid Biochem. Mol. Biol. 101 (2006) 246-253
63. Hwang J.T., Park I.J., Shin J.I., Lee Y.K., Lee S.K., Baik H.W., Ha J., and Park O.J. Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochem. Biophys. Res. Commun. 338 (2005) 694-699
64. Ikeda Y., Iki M., Morita A., Kajita E., Kagamimori S., Kagawa Y., and Yoneshima H. Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study. J. Nutr. 136 (2006) 1323-1328
65. Jang E.H., Moon J.S., Ko J.H., Ahn C.W., Lee H.H., Shin J.K., Park C.S., and Kang J.H. Novel black soy peptides with antiobesity effects: activation of leptin-like signaling and AMP-activated protein kinase. Int. J. Obes. (Lond.) 32 (2008) 1161-1170
66. Jayagopal V., Albertazzi P., Kilpatrick E.S., Howarth E.M., Jennings P.E., Hepburn D.A., and Atkin S.L. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care 25 (2002) 1709-1714
67. Jefferson W.N., Padilla-Banks E., and Newbold R.R. Adverse effects on female development and reproduction in CD-1 mice following neonatal exposure to the phytoestrogen genistein at environmentally relevant doses. Biol. Reprod. 73 (2005) 798-806
68. Jefferson W.N., Padilla-Banks E., and Newbold R.R. Disruption of the female reproductive system by the phytoestrogen genistein. Reprod. Toxicol. 23 (2007) 308-316
69. Jones M.E., Thorburn A.W., Britt K.L., Hewitt K.N., Wreford N.G., Proietto J., Oz O.K., Leury B.J., Robertson K.M., Yao S., and Simpson E.R. Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 12735-12740
70. Ju Y.H., Doerge D.R., Allred K.F., Allred C.D., and Helferich W.G. Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Res. 62 (2002) 2474-2477
71. Kim E.K., Kwon K.B., Song M.Y., Seo S.W., Park S.J., Ka S.O., Na L., Kim K.A., Ryu D.G., So H.S., Park R., Park J.W., and Park B.H. Genistein protects pancreatic beta cells against cytokine-mediated toxicity. Mol. Cell. Endocrinol. 278 (2007) 18-28
72. King R.A., and Bursill D.B. Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. Am. J. Clin. Nutr. 67 (1998) 867-872
73. Kirk E.A., Sutherland P., Wang S.A., Chait A., and LeBoeuf R.C. Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. J. Nutr. 128 (1998) 954-959
74. Kohno M., Hirotsuka M., Kito M., and Matsuzawa Y. Decreases in serum triacylglycerol and visceral fat mediated by dietary soybean beta-conglycinin. J. Atheroscler. Thromb. 13 (2006) 247-255
75. Kok L., Kreijkamp-Kaspers S., Grobbee D.E., Lampe J.W., and van der Schouw Y.T. Soy isoflavones, body composition, and physical performance. Maturitas 52 (2005) 102-110
76. Kuiper G.G., Carlsson B., Grandien K., Enmark E., Haggblad J., Nilsson S., and Gustafsson J.A. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138 (1997) 863-870
77. Kuiper G.G., Lemmen J.G., Carlsson B., Corton J.C., Safe S.H., van der Saag P.T., van der Burg B., and Gustafsson J.A. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139 (1998) 4252-4263
78. Lavigne C., Marette A., and Jacques H. Cod and soy proteins compared with casein improve glucose tolerance and insulin sensitivity in rats. Am. J. Physiol. Endocrinol. Metab. 278 (2000) E491-500
79. Le May C., Chu K., Hu M., Ortega C.S., Simpson E.R., Korach K.S., Tsai M.J., and Mauvais-Jarvis F. Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 9232-9237
80. Lee J.S. Effects of soy protein and genistein on blood glucose, antioxidant enzyme activities, and lipid profile in streptozotocin-induced diabetic rats. Life Sci. 79 (2006) 1578-1584
81. Leopold A.S., Erwin M., Oh J., and Browning B. Phytoestrogens: adverse effects on reproduction in California quail. Science 191 (1976) 98-100
82. Lephart E.D., Rhees R.W., Setchell K.D., Bu L.H., and Lund T.D. Estrogens and phytoestrogens: brain plasticity of sexually dimorphic brain volumes. J. Steroid Biochem. Mol. Biol. 85 (2003) 299-309
83. Lephart E.D., Porter J.P., Lund T.D., Bu L., Setchell K.D., Ramoz G., and Crowley W.R. Dietary isoflavones alter regulatory behaviors, metabolic hormones and neuroendocrine function in Long-Evans male rats. Nutr. Metab. (Lond.) 1 (2004) 16
84. Lephart E.D., Setchell K.D., Handa R.J., and Lund T.D. Behavioral effects of endocrine-disrupting substances: phytoestrogens. Ilar. J. 45 (2004) 443-454
85. Li Z., Hong K., Saltsman P., DeShields S., Bellman M., Thames G., Liu Y., Wang H.J., Elashoff R., and Heber D. Long-term efficacy of soy-based meal replacements vs an individualized diet plan in obese type II DM patients: relative effects on weight loss, metabolic parameters, and C-reactive protein. Eur. J. Clin. Nutr. 59 (2005) 411-418
86. Liang Y.Q., Akishita M., Kim S., Ako J., Hashimoto M., Iijima K., Ohike Y., Watanabe T., Sudoh N., Toba K., Yoshizumi M., and Ouchi Y. Estrogen receptor beta is involved in the anorectic action of estrogen. Int. J. Obes. Relat. Metab. Disord. 26 (2002) 1103-1109
87. Lin J., Handschin C., and Spiegelman B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell. Metab. 1 (2005) 361-370
88. Liu B., Edgerton S., Yang X., Kim A., Ordonez-Ercan D., Mason T., Alvarez K., McKimmey C., Liu N., and Thor A. Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention. Cancer Res. 65 (2005) 879-886
89. Liu D., Zhen W., Yang Z., Carter J.D., Si H., and Reynolds K.A. Genistein acutely stimulates insulin secretion in pancreatic beta-cells through a cAMP-dependent protein kinase pathway. Diabetes 55 (2006) 1043-1050
90. Louet J.F., LeMay C., and Mauvais-Jarvis F. Antidiabetic actions of estrogen: insight from human and genetic mouse models. Curr. Atheroscler. Rep. 6 (2004) 180-185
91. Lukaczer D., Liska D.J., Lerman R.H., Darland G., Schiltz B., Tripp M., and Bland J.S. Effect of a low glycemic index diet with soy protein and phytosterols on CVD risk factors in postmenopausal women. Nutrition 22 (2006) 104-113
92. Makela S., Davis V.L., Tally W.C., Korkman J., Salo L., Vihko R., Santti R., and Korach K.S. Dietary estrogens act through estrogen receptor-mediated processes and show no antiestrogenicity in cultured breast cancer cells. Environ. Health Perspect. 102 (1994) 572-578
93. Makela S., Santti R., Salo L., and McLachlan J.A. Phytoestrogens are partial estrogen agonists in the adult male mouse. Environ. Health Perspect. 103 Suppl 7 (1995) 123-127
94. Makimura H., Mizuno T.M., Mastaitis J.W., Agami R., and Mobbs C.V. Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. BMC Neurosci. 3 (2002) 18
95. Martensson U.E.A., Salehi A.S., Windahl S., Gomez M.F., Swärd K., Daszkiewicz-Nilsson J., Wendt A., Andersson N., Hellstrand P., Grände P.-O., Owman C., Rosen C.J., Adamo M.L., Lundquist I., Rorsman P., Nilsson B.-O., Ohlsson C., Olde B., and Leeb-Lundberg L.M.F. Deletion of the G protein-coupled receptor GRP30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology (2008) 2008-2623 10. 1210/en.
96. Meli R., Pacilio M., Raso G.M., Esposito E., Coppola A., Nasti A., Di Carlo C., Nappi C., and Di Carlo R. Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats. Endocrinology 145 (2004) 3115-3121
97. Moriyama T., Kishimoto K., Nagai K., Urade R., Ogawa T., Utsumi S., Maruyama N., and Maebuchi M. Soybean beta-conglycinin diet suppresses serum triglyceride levels in normal and genetically obese mice by induction of beta-oxidation, downregulation of fatty acid synthase, and inhibition of triglyceride absorption. Biosci. Biotechnol. Biochem. 68 (2004) 352-359
98. Morton M.S., Wilcox G., Wahlqvist M.L., and Griffiths K. Determination of lignans and isoflavonoids in human female plasma following dietary supplementation. J. Endocrinol. 142 (1994) 251-259
99. Musatov S., Chen W., Pfaff D.W., Mobbs C.V., Yang X.J., Clegg D.J., Kaplitt M.G., and Ogawa S. Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 2501-2506
100. Nadal A., Rovira J.M., Laribi O., Leon-Quinto T., Andreu E., Ripoll C., and Soria B. Rapid insulinotropic effect of 17beta-estradiol via a plasma membrane receptor. FASEB J. 12 (1998) 1341-1348
101. Naaz A., Yellayi S., Zakroczymski M.A., Bunick D., Doerge D.R., Lubahn D.B., Helferich W.G., and Cooke P.S. The soy isoflavone genistein decreases adipose deposition in mice. Endocrinology 144 (2003) 3315-3320
102. Nagasawa A., Fukui K., Kojima M., Kishida K., Maeda N., Nagaretani H., Hibuse T., Nishizawa H., Kihara S., Waki M., Takamatsu K., Funahashi T., and Matsuzawa Y. Divergent effects of soy protein diet on the expression of adipocytokines. Biochem. Biophys. Res. Commun. 311 (2003) 909-914
103. Nemoto Y., Toda K., Ono M., Fujikawa-Adachi K., Saibara T., Onishi S., Enzan H., Okada T., and Shizuta Y. Altered expression of fatty acid-metabolizing enzymes in aromatase-deficient mice. J. Clin. Invest. 105 (2000) 1819-1825
104. Newbold R.R., Banks E.P., Bullock B., and Jefferson W.N. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res. 61 (2001) 4325-4328
105. Nordentoft I., Jeppesen P.B., Hong J., Abudula R., and Hermansen K. Increased insulin sensitivity and changes in the expression profile of key insulin regulatory genes and beta cell transcription factors in diabetic KKAy-mice after feeding with a soy bean protein rich diet high in isoflavone content. J. Agric. Food Chem. 56 (2008) 4377-4385
106. Oakenfull D. Soy protein, saponins and plasma cholesterol. J. Nutr. 131 (2001) 2971-2972
107. Ogawa S., Chan J., Gustafsson J.A., Korach K.S., and Pfaff D.W. Estrogen increases locomotor activity in mice through estrogen receptor alpha: specificity for the type of activity. Endocrinology 144 (2003) 230-239
108. Ohlsson C., Hellberg N., Parini P., Vidal O., Bohlooly Y.M., Rudling M., Lindberg M.K., Warner M., Angelin B., and Gustafsson J.A. Obesity and disturbed lipoprotein profile in estrogen receptor-alpha-deficient male mice. Biochem. Biophys. Res. Commun. 278 (2000) 640-645
109. Olshansky S.J., Passaro D.J., Hershow R.C., Layden J., Carnes B.A., Brody J., Hayflick L., Butler R.N., Allison D.B., and Ludwig D.S. A potential decline in life expectancy in the United States in the 21st century. N. Engl. J. Med. 352 (2005) 1138-1145
110. Penza M., Montani C., Romani A., Vignolini P., Pampaloni B., Tanini A., Brandi M.L., Alonso-Magdalena P., Nadal A., Ottobrini L., Parolini O., Bignotti E., Calza S., Maggi A., Grigolato P.G., and Di Lorenzo D. Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner. Endocrinology 147 (2006) 5740-5751
111. Ruderman N., and Prentki M. AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat. Rev. Drug. Discov. 3 (2004) 340-351
112. Ruhlen R.L., Howdeshell K.L., Mao J., Taylor J.A., Bronson F.H., Newbold R.R., Welshons W.V., and vom Saal F.S. Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the "fetal estrogenization syndrome" and obesity in CD-1 mice. Environ. Health Perspect. 116 (2008) 322-328
113. Sacks F.M., Lichtenstein A., Van Horn L., Harris W., Kris-Etherton P., and Winston M. Soy protein, isoflavones, and cardiovascular health: an American Heart Association Science Advisory for professionals from the Nutrition Committee. Circulation 113 (2006) 1034-1044
114. Sanders T.A., Dean T.S., Grainger D., Miller G.J., and Wiseman H. Moderate intakes of intact soy protein rich in isoflavones compared with ethanol-extracted soy protein increase HDL but do not influence transforming growth factor beta(1) concentrations and hemostatic risk factors for coronary heart disease in healthy subjects. Am. J. Clin. Nutr. 76 (2002) 373-377
115. Schwartz M.W., Woods S.C., Porte Jr. D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2000) 661-671
116. Setchell K.D. Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Am. J. Clin. Nutr. 68 (1998) 1333S-1346S
117. Setchell K.D., Brown N.M., Desai P., Zimmer-Nechemias L., Wolfe B.E., Brashear W.T., Kirschner A.S., Cassidy A., and Heubi J.E. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J. Nutr. 131 (2001) S1362-S1375
118. Setchell K.D. Assessing risks and benefits of genistein and soy. Environ. Health Perspect. 114 (2006) A332-A333
119. Stutz A.M., Morrison C.D., and Argyropoulos G. The Agouti-related protein and its role in energy homeostasis. Peptides 26 (2005) 1771-1781
120. Szkudelska K., Nogowski L., and Szkudelski T. Genistein affects lipogenesis and lipolysis in isolated rat adipocytes. J. Steroid Biochem. Mol. Biol. 75 (2000) 265-271
121. Takatsuka N., Nagata C., Kurisu Y., Inaba S., Kawakami N., and Shimizu H. Hypocholesterolemic effect of soymilk supplementation with usual diet in premenopausal normolipidemic Japanese women. Prev. Med. 31 (2000) 308-314
122. Takeda K., Toda K., Saibara T., Nakagawa M., Saika K., Onishi T., Sugiura T., and Shizuta Y. Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency. J. Endocrinol. 176 (2003) 237-246
123. Teixeira S.R., Potter S.M., Weigel R., Hannum S., Erdman Jr. J.W., and Hasler C.M. Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men. Am. J. Clin. Nutr. 71 (2000) 1077-1084
124. Tham D.M., Gardner C.D., and Haskell W.L. Clinical review 97: potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. J. Clin. Endocrinol. Metab. 83 (1998) 2223-2235
125. Thigpen J.E., Haseman J.K., Saunders H.E., Setchell K.D., Grant M.G., and Forsythe D.B. Dietary phytoestrogens accelerate the time of vaginal opening in immature CD-1 mice. Comp. Med. 53 (2003) 607-615
126. Torre-Villalvazo I., Tovar A.R., Ramos-Barragan V.E., Cerbon-Cervantes M.A., and Torres N. Soy protein ameliorates metabolic abnormalities in liver and adipose tissue of rats fed a high fat diet. J. Nutr. 138 (2008) 462-468
127. United States Department of Agriculture. Composition of foods: fats and oils. USDA Handbook 8-4 (1979), USDA, Washington, DC
128. van Erp-Baart M.A., Brants H.A., Kiely M., Mulligan A., Turrini A., Sermoneta C., Kilkkinen A., and Valsta L.M. Isoflavone intake in four different European countries: the VENUS approach. Br. J. Nutr. 89 Suppl 1 (2003) S25-S30
129. Vedavanam K., Srijayanta S., O'Reilly J., Raman A., and Wiseman H. Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE). Phytother. Res. 13 (1999) 601-608
130. Velasquez M.T., and Bhathena S.J. Role of dietary soy protein in obesity. Int. J. Med. Sci. 4 (2007) 72-82
131. Wang H.J., and Murphy P.A. Isoflavone composition of American and Japanese soybeans in Iowa: effects of variety, crop year, and location. J. Agric. Food Chem. 42 (1994) 1674-1677
132. Watanabe S., Yamaguchi M., Sobue T., Takahashi T., Miura T., Arai Y., Mazur W., Wahala K., and Adlercreutz H. Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (kinako). J. Nutr. 128 (1998) 1710-1715
133. Weber K.S., Setchell K.D., Stocco D.M., and Lephart E.D. Dietary soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats. J. Endocrinol. 170 (2001) 591-599
134. Weickert M.O., Reimann M., Otto B., Hall W.L., Vafeiadou K., Hallund J., Ferrari M., Talbot D., Branca F., Bugel S., Williams C.M., Zunft H.J., and Koebnick C. Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women. J. Negat. Results. Biomed. 5 (2006) 11
135. Winder W.W., and Hardie D.G. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am. J. Physiol. 270 (1996) E299-304
136. Wortley K.E., Anderson K.D., Yasenchak J., Murphy A., Valenzuela D., Diano S., Yancopoulos G.D., Wiegand S.J., and Sleeman M.W. Agouti-related protein-deficient mice display an age-related lean phenotype. Cell. Metab. 2 (2005) 421-427
137. Wu A.H., Wan P., Hankin J., Tseng C.C., Yu M.C., and Pike M.C. Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis 23 (2002) 1491-1496
138. Wu J., Wang X., Chiba H., Higuchi M., Nakatani T., Ezaki O., Cui H., Yamada K., and Ishimi Y. Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice. Metabolism 53 (2004) 942-948
139. Wu J., Oka J., Higuchi M., Tabata I., Toda T., Fujioka M., Fuku N., Teramoto T., Okuhira T., Ueno T., Uchiyama S., Urata K., Yamada K., and Ishimi Y. Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trial. Metabolism 55 (2006) 423-433
140. Xu X., Wang H.J., Murphy P.A., Cook L., and Hendrich S. Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J. Nutr. 124 (1994) 825-832
141. Yamashita T., Sasahara T., Pomeroy S.E., Collier G., and Nestel P.J. Arterial compliance, blood pressure, plasma leptin, and plasma lipids in women are improved with weight reduction equally with a meat-based diet and a plant-based diet. Metabolism 47 (1998) 1308-1314
142. Yang G., Shu X.O., Jin F., Elasy T., Li H.L., Li Q., Huang F., Zhang X.L., Gao Y.T., and Zheng W. Soyfood consumption and risk of glycosuria: a cross-sectional study within the Shanghai Women's Health Study. Eur. J. Clin. Nutr. 58 (2004) 615-620
143. Zong H., Ren J.M., Young L.H., Pypaert M., Mu J., Birnbaum M.J., and Shulman G.I. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 15983-15987