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Volumn 287, Issue , 2017, Pages 409-422

CNS repair and axon regeneration: Using genetic variation to determine mechanisms

Author keywords

Activin TGF signaling; CAST Ei; CNS regeneration; Collaborative cross; Congenics; Genetic background; Neuron intrinsic and extrinsic factors

Indexed keywords

ACTIVIN; CHONDROITIN ABC LYASE; DOUBLECORTIN LIKE KINASE; DOUBLECORTIN LIKE KINASE 2; GROWTH DIFFERENTIATION FACTOR 10; GROWTH DIFFERENTIATION FACTOR 15; KRUPPEL LIKE FACTOR 4; KRUPPEL LIKE FACTOR 7; LIM KINASE 1; MYC PROTEIN; NEUROTROPHIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEOGLYCAN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; ROCK2 PROTEIN; ROUNDABOUT LIKE PROTEIN 1; ROUNDABOUT RECEPTOR; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 84975509455     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2016.05.004     Document Type: Review
Times cited : (22)

References (156)
  • 2
    • 79960405675 scopus 로고    scopus 로고
    • Functional regeneration of respiratory pathways after spinal cord injury
    • Alilain, W.J., Horn, K.P., Hu, H., Dick, T.E., Silver, J., Functional regeneration of respiratory pathways after spinal cord injury. Nature 475 (2011), 196–200.
    • (2011) Nature , vol.475 , pp. 196-200
    • Alilain, W.J.1    Horn, K.P.2    Hu, H.3    Dick, T.E.4    Silver, J.5
  • 3
    • 77955005722 scopus 로고    scopus 로고
    • Identification of wild-derived inbred mouse strains highly susceptible to monkeypox virus infection for use as small animal models
    • Americo, J.L., Moss, B., Earl, P.L., Identification of wild-derived inbred mouse strains highly susceptible to monkeypox virus infection for use as small animal models. J. Virol. 84 (2010), 8172–8180.
    • (2010) J. Virol. , vol.84 , pp. 8172-8180
    • Americo, J.L.1    Moss, B.2    Earl, P.L.3
  • 5
    • 84928892831 scopus 로고    scopus 로고
    • Regulatory networks in retinal ischemia-reperfusion injury
    • Andreeva, K., Soliman, M.M., Cooper, N.G., Regulatory networks in retinal ischemia-reperfusion injury. BMC Genet., 16, 2015, 43.
    • (2015) BMC Genet. , vol.16 , pp. 43
    • Andreeva, K.1    Soliman, M.M.2    Cooper, N.G.3
  • 7
    • 0034307763 scopus 로고    scopus 로고
    • Live or let die - retinal ganglion cell death and survival during development and in the lesioned adult CNS
    • Bahr, M., Live or let die - retinal ganglion cell death and survival during development and in the lesioned adult CNS. Trends Neurosci. 23 (2000), 483–490.
    • (2000) Trends Neurosci. , vol.23 , pp. 483-490
    • Bahr, M.1
  • 8
    • 0027263342 scopus 로고
    • Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy
    • Barone, F.C., Knudsen, D.J., Nelson, A.H., Feuerstein, G.Z., Willette, R.N., Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy. J. Cereb. Blood Flow Metab. 13 (1993), 683–692.
    • (1993) J. Cereb. Blood Flow Metab. , vol.13 , pp. 683-692
    • Barone, F.C.1    Knudsen, D.J.2    Nelson, A.H.3    Feuerstein, G.Z.4    Willette, R.N.5
  • 9
    • 0030157694 scopus 로고    scopus 로고
    • Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection
    • Basso, D.M., Beattie, M.S., Bresnahan, J.C., Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp. Neurol. 139 (1996), 244–256.
    • (1996) Exp. Neurol. , vol.139 , pp. 244-256
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 10
    • 33645983692 scopus 로고    scopus 로고
    • Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
    • Basso, D.M., Fisher, L.C., Anderson, A.J., Jakeman, L.B., McTigue, D.M., Popovich, P.G., Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J. Neurotrauma 23 (2006), 635–659.
    • (2006) J. Neurotrauma , vol.23 , pp. 635-659
    • Basso, D.M.1    Fisher, L.C.2    Anderson, A.J.3    Jakeman, L.B.4    McTigue, D.M.5    Popovich, P.G.6
  • 14
    • 76249112565 scopus 로고    scopus 로고
    • Evolution of animal regeneration: re-emergence of a field
    • Bely, A.E., Nyberg, K.G., Evolution of animal regeneration: re-emergence of a field. Trends Ecol. Evol. 25 (2010), 161–170.
    • (2010) Trends Ecol. Evol. , vol.25 , pp. 161-170
    • Bely, A.E.1    Nyberg, K.G.2
  • 15
    • 84998734713 scopus 로고    scopus 로고
    • Reaching the Brain: Advances in Optic Nerve Regeneration
    • (Exp Neurol)
    • Benowitz, L.I., He, Z., Goldberg, J.L., Reaching the Brain: Advances in Optic Nerve Regeneration. 2015 (Exp Neurol).
    • (2015)
    • Benowitz, L.I.1    He, Z.2    Goldberg, J.L.3
  • 17
    • 0028310855 scopus 로고
    • Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats
    • Berkelaar, M., Clarke, D.B., Wang, Y.C., Bray, G.M., Aguayo, A.J., Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J. Neurosci. 14 (1994), 4368–4374.
    • (1994) J. Neurosci. , vol.14 , pp. 4368-4374
    • Berkelaar, M.1    Clarke, D.B.2    Wang, Y.C.3    Bray, G.M.4    Aguayo, A.J.5
  • 19
    • 58149512333 scopus 로고    scopus 로고
    • Spinal cord injury: plasticity, regeneration and the challenge of translational drug development
    • Blesch, A., Tuszynski, M.H., Spinal cord injury: plasticity, regeneration and the challenge of translational drug development. Trends Neurosci. 32 (2009), 41–47.
    • (2009) Trends Neurosci. , vol.32 , pp. 41-47
    • Blesch, A.1    Tuszynski, M.H.2
  • 20
    • 84943816845 scopus 로고    scopus 로고
    • Collaborative cross and diversity outbred data resources in the mouse phenome database
    • Bogue, M.A., Churchill, G.A., Chesler, E.J., Collaborative cross and diversity outbred data resources in the mouse phenome database. Mamm. Genome 26 (2015), 511–520.
    • (2015) Mamm. Genome , vol.26 , pp. 511-520
    • Bogue, M.A.1    Churchill, G.A.2    Chesler, E.J.3
  • 22
    • 2342493315 scopus 로고    scopus 로고
    • Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice
    • Cafferty, W.B., Gardiner, N.J., Das, P., Qiu, J., McMahon, S.B., Thompson, S.W., Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice. J. Neurosci. 24 (2004), 4432–4443.
    • (2004) J. Neurosci. , vol.24 , pp. 4432-4443
    • Cafferty, W.B.1    Gardiner, N.J.2    Das, P.3    Qiu, J.4    McMahon, S.B.5    Thompson, S.W.6
  • 23
    • 22444447946 scopus 로고    scopus 로고
    • Common mechanisms of nerve and blood vessel wiring
    • Carmeliet, P., Tessier-Lavigne, M., Common mechanisms of nerve and blood vessel wiring. Nature 436 (2005), 193–200.
    • (2005) Nature , vol.436 , pp. 193-200
    • Carmeliet, P.1    Tessier-Lavigne, M.2
  • 24
    • 84998588261 scopus 로고    scopus 로고
    • The 3 Rs of stroke biology: radial, relayed, and regenerative
    • Carmichael, S.T., The 3 Rs of stroke biology: radial, relayed, and regenerative. Neurotherapeutics, 2015.
    • (2015) Neurotherapeutics
    • Carmichael, S.T.1
  • 25
    • 33645777249 scopus 로고    scopus 로고
    • Regeneration of the adult central nervous system
    • Case, L.C., Tessier-Lavigne, M., Regeneration of the adult central nervous system. Curr. Biol. 15 (2005), R749–R753.
    • (2005) Curr. Biol. , vol.15 , pp. R749-R753
    • Case, L.C.1    Tessier-Lavigne, M.2
  • 28
    • 84887959502 scopus 로고    scopus 로고
    • Injury-induced HDAC5 nuclear export is essential for axon regeneration
    • Cho, Y., Sloutsky, R., Naegle, K.M., Cavalli, V., Injury-induced HDAC5 nuclear export is essential for axon regeneration. Cell 155 (2013), 894–908.
    • (2013) Cell , vol.155 , pp. 894-908
    • Cho, Y.1    Sloutsky, R.2    Naegle, K.M.3    Cavalli, V.4
  • 29
    • 77954480424 scopus 로고    scopus 로고
    • PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons
    • Christie, K.J., Webber, C.A., Martinez, J.A., Singh, B., Zochodne, D.W., PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons. J. Neurosci. 30 (2010), 9306–9315.
    • (2010) J. Neurosci. , vol.30 , pp. 9306-9315
    • Christie, K.J.1    Webber, C.A.2    Martinez, J.A.3    Singh, B.4    Zochodne, D.W.5
  • 30
    • 84960194716 scopus 로고    scopus 로고
    • Regulatory evolution of innate immunity through co-option of endogenous retroviruses
    • Chuong, E.B., Elde, N.C., Feschotte, C., Regulatory evolution of innate immunity through co-option of endogenous retroviruses. Science 351 (2016), 1083–1087.
    • (2016) Science , vol.351 , pp. 1083-1087
    • Chuong, E.B.1    Elde, N.C.2    Feschotte, C.3
  • 35
    • 0003668973 scopus 로고
    • On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life. Fellow of the Royal, Geological, Linnæan, etc. societies; Author of Journal of researches during H. M. S. Beagle's Voyage round the world
    • London: John Murray Albemarle Street
    • Darwin, C., On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life. Fellow of the Royal, Geological, Linnæan, etc. societies; Author of Journal of researches during H. M. S. Beagle's Voyage round the world. 1859, London: John Murray, Albemarle Street.
    • (1859)
    • Darwin, C.1
  • 36
    • 79959379095 scopus 로고    scopus 로고
    • Repertoire of microglial and macrophage responses after spinal cord injury
    • David, S., Kroner, A., Repertoire of microglial and macrophage responses after spinal cord injury. Nat. Rev. Neurosci. 12 (2011), 388–399.
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 388-399
    • David, S.1    Kroner, A.2
  • 38
    • 84914670481 scopus 로고    scopus 로고
    • Regulation of IL-10 by chondroitinase ABC promotes a distinct immune response following spinal cord injury
    • Didangelos, A., Iberl, M., Vinsland, E., Bartus, K., Bradbury, E.J., Regulation of IL-10 by chondroitinase ABC promotes a distinct immune response following spinal cord injury. J. Neurosci. 34 (2014), 16424–16432.
    • (2014) J. Neurosci. , vol.34 , pp. 16424-16432
    • Didangelos, A.1    Iberl, M.2    Vinsland, E.3    Bartus, K.4    Bradbury, E.J.5
  • 39
    • 50149092254 scopus 로고    scopus 로고
    • Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice
    • Dietz, J.A., Li, Y., Chung, L.M., Yandell, B.S., Schlamp, C.L., Nickells, R.W., Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice. BMC Neurosci., 9, 2008, 74.
    • (2008) BMC Neurosci. , vol.9 , pp. 74
    • Dietz, J.A.1    Li, Y.2    Chung, L.M.3    Yandell, B.S.4    Schlamp, C.L.5    Nickells, R.W.6
  • 45
    • 84889785400 scopus 로고    scopus 로고
    • Epigenetic regulation of sensory axon regeneration after spinal cord injury
    • Finelli, M.J., Wong, J.K., Zou, H., Epigenetic regulation of sensory axon regeneration after spinal cord injury. J. Neurosci. 33 (2013), 19664–19676.
    • (2013) J. Neurosci. , vol.33 , pp. 19664-19676
    • Finelli, M.J.1    Wong, J.K.2    Zou, H.3
  • 47
    • 0031840938 scopus 로고    scopus 로고
    • Cytokine-induced changes in the ability of astrocytes to support migration of oligodendrocyte precursors and axon growth
    • Fok-Seang, J., DiProspero, N.A., Meiners, S., Muir, E., Fawcett, J.W., Cytokine-induced changes in the ability of astrocytes to support migration of oligodendrocyte precursors and axon growth. Eur. J. Neurosci. 10 (1998), 2400–2415.
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 2400-2415
    • Fok-Seang, J.1    DiProspero, N.A.2    Meiners, S.3    Muir, E.4    Fawcett, J.W.5
  • 48
    • 0030770634 scopus 로고    scopus 로고
    • Strain-related differences in susceptibility to transient forebrain ischemia in SV-129 and C57black/6 mice
    • (discussion 1811)
    • Fujii, M., Hara, H., Meng, W., Vonsattel, J.P., Huang, Z., Moskowitz, M.A., Strain-related differences in susceptibility to transient forebrain ischemia in SV-129 and C57black/6 mice. Stroke; a journal of cerebral circulation 28 (1997), 1805–1810 (discussion 1811).
    • (1997) Stroke; a journal of cerebral circulation , vol.28 , pp. 1805-1810
    • Fujii, M.1    Hara, H.2    Meng, W.3    Vonsattel, J.P.4    Huang, Z.5    Moskowitz, M.A.6
  • 49
    • 69449093524 scopus 로고    scopus 로고
    • Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation
    • Garcia-Alias, G., Barkhuysen, S., Buckle, M., Fawcett, J.W., Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation. Nat. Neurosci. 12 (2009), 1145–1151.
    • (2009) Nat. Neurosci. , vol.12 , pp. 1145-1151
    • Garcia-Alias, G.1    Barkhuysen, S.2    Buckle, M.3    Fawcett, J.W.4
  • 50
    • 84884698652 scopus 로고    scopus 로고
    • Tissue absence initiates regeneration through follistatin-mediated inhibition of activin signaling
    • e00247
    • Gavino, M.A., Wenemoser, D., Wang, I.E., Reddien, P.W., Tissue absence initiates regeneration through follistatin-mediated inhibition of activin signaling. eLife, 2, 2013, e00247.
    • (2013) eLife , vol.2
    • Gavino, M.A.1    Wenemoser, D.2    Wang, I.E.3    Reddien, P.W.4
  • 51
    • 84879316245 scopus 로고    scopus 로고
    • Characterization of TGFbeta signaling during tail regeneration in the leopard gecko (Eublepharis macularius)
    • Gilbert, R.W., Vickaryous, M.K., Viloria-Petit, A.M., Characterization of TGFbeta signaling during tail regeneration in the leopard gecko (Eublepharis macularius). Dev. Dyn. 242 (2013), 886–896.
    • (2013) Dev. Dyn. , vol.242 , pp. 886-896
    • Gilbert, R.W.1    Vickaryous, M.K.2    Viloria-Petit, A.M.3
  • 52
    • 84861587180 scopus 로고    scopus 로고
    • Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish
    • Goldshmit, Y., Sztal, T.E., Jusuf, P.R., Hall, T.E., Nguyen-Chi, M., Currie, P.D., Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish. J. Neurosci. 32 (2012), 7477–7492.
    • (2012) J. Neurosci. , vol.32 , pp. 7477-7492
    • Goldshmit, Y.1    Sztal, T.E.2    Jusuf, P.R.3    Hall, T.E.4    Nguyen-Chi, M.5    Currie, P.D.6
  • 55
    • 39249083835 scopus 로고    scopus 로고
    • TGF-beta signaling is required for multiple processes during Xenopus tail regeneration
    • Ho, D.M., Whitman, M., TGF-beta signaling is required for multiple processes during Xenopus tail regeneration. Dev. Biol. 315 (2008), 203–216.
    • (2008) Dev. Biol. , vol.315 , pp. 203-216
    • Ho, D.M.1    Whitman, M.2
  • 56
    • 0342902626 scopus 로고    scopus 로고
    • Strong induction of activin expression after injury suggests an important role of activin in wound repair
    • Hubner, G., Hu, Q., Smola, H., Werner, S., Strong induction of activin expression after injury suggests an important role of activin in wound repair. Dev. Biol. 173 (1996), 490–498.
    • (1996) Dev. Biol. , vol.173 , pp. 490-498
    • Hubner, G.1    Hu, Q.2    Smola, H.3    Werner, S.4
  • 57
    • 70249093289 scopus 로고    scopus 로고
    • Axon regeneration in the peripheral and central nervous systems
    • Huebner, E.A., Strittmatter, S.M., Axon regeneration in the peripheral and central nervous systems. Results Probl. Cell Differ. 48 (2009), 339–351.
    • (2009) Results Probl. Cell Differ. , vol.48 , pp. 339-351
    • Huebner, E.A.1    Strittmatter, S.M.2
  • 58
    • 77958481851 scopus 로고    scopus 로고
    • Involvement of the serum response factor coactivator megakaryoblastic leukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons
    • Ishikawa, M., Nishijima, N., Shiota, J., Sakagami, H., Tsuchida, K., Mizukoshi, M., Fukuchi, M., Tsuda, M., Tabuchi, A., Involvement of the serum response factor coactivator megakaryoblastic leukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons. J. Biol. Chem. 285 (2010), 32734–32743.
    • (2010) J. Biol. Chem. , vol.285 , pp. 32734-32743
    • Ishikawa, M.1    Nishijima, N.2    Shiota, J.3    Sakagami, H.4    Tsuchida, K.5    Mizukoshi, M.6    Fukuchi, M.7    Tsuda, M.8    Tabuchi, A.9
  • 60
    • 34547909927 scopus 로고    scopus 로고
    • Activin-betaA signaling is required for zebrafish fin regeneration
    • Jazwinska, A., Badakov, R., Keating, M.T., Activin-betaA signaling is required for zebrafish fin regeneration. Current biology: CB 17 (2007), 1390–1395.
    • (2007) Current biology: CB , vol.17 , pp. 1390-1395
    • Jazwinska, A.1    Badakov, R.2    Keating, M.T.3
  • 61
    • 0036548768 scopus 로고    scopus 로고
    • Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: Implications for autoimmune vaccine therapy
    • Jones, T.B., Basso, D.M., Sodhi, A., Pan, J.Z., Hart, R.P., MacCallum, R.C., Lee, S., Whitacre, C.C., Popovich, P.G., Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: Implications for autoimmune vaccine therapy. J. Neurosci. 22 (2002), 2690–2700.
    • (2002) J. Neurosci. , vol.22 , pp. 2690-2700
    • Jones, T.B.1    Basso, D.M.2    Sodhi, A.3    Pan, J.Z.4    Hart, R.P.5    MacCallum, R.C.6    Lee, S.7    Whitacre, C.C.8    Popovich, P.G.9
  • 62
    • 1942521774 scopus 로고    scopus 로고
    • Passive or active immunization with myelin basic protein impairs neurological function and exacerbates neuropathology after spinal cord injury in rats
    • Jones, T.B., Ankeny, D.P., Guan, Z., McGaughy, V., Fisher, L.C., Basso, D.M., Popovich, P.G., Passive or active immunization with myelin basic protein impairs neurological function and exacerbates neuropathology after spinal cord injury in rats. J. Neurosci. 24 (2004), 3752–3761.
    • (2004) J. Neurosci. , vol.24 , pp. 3752-3761
    • Jones, T.B.1    Ankeny, D.P.2    Guan, Z.3    McGaughy, V.4    Fisher, L.C.5    Basso, D.M.6    Popovich, P.G.7
  • 63
    • 84893154288 scopus 로고    scopus 로고
    • Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury
    • Kanno, H., Pressman, Y., Moody, A., Berg, R., Muir, E.M., Rogers, J.H., Ozawa, H., Itoi, E., Pearse, D.D., Bunge, M.B., Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury. J. Neurosci. 34 (2014), 1838–1855.
    • (2014) J. Neurosci. , vol.34 , pp. 1838-1855
    • Kanno, H.1    Pressman, Y.2    Moody, A.3    Berg, R.4    Muir, E.M.5    Rogers, J.H.6    Ozawa, H.7    Itoi, E.8    Pearse, D.D.9    Bunge, M.B.10
  • 65
    • 18644384444 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury
    • Keirstead, H.S., Nistor, G., Bernal, G., Totoiu, M., Cloutier, F., Sharp, K., Steward, O., Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J. Neurosci. 25 (2005), 4694–4705.
    • (2005) J. Neurosci. , vol.25 , pp. 4694-4705
    • Keirstead, H.S.1    Nistor, G.2    Bernal, G.3    Totoiu, M.4    Cloutier, F.5    Sharp, K.6    Steward, O.7
  • 66
    • 18844436224 scopus 로고    scopus 로고
    • In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
    • Kerschensteiner, M., Schwab, M.E., Lichtman, J.W., Misgeld, T., In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nat. Med. 11 (2005), 572–577.
    • (2005) Nat. Med. , vol.11 , pp. 572-577
    • Kerschensteiner, M.1    Schwab, M.E.2    Lichtman, J.W.3    Misgeld, T.4
  • 67
    • 30144445614 scopus 로고    scopus 로고
    • Comparative analysis of lesion development and intraspinal inflammation in four strains of mice following spinal contusion injury
    • Kigerl, K.A., McGaughy, V.M., Popovich, P.G., Comparative analysis of lesion development and intraspinal inflammation in four strains of mice following spinal contusion injury. J. Comp. Neurol. 494 (2006), 578–594.
    • (2006) J. Comp. Neurol. , vol.494 , pp. 578-594
    • Kigerl, K.A.1    McGaughy, V.M.2    Popovich, P.G.3
  • 68
    • 70350558453 scopus 로고    scopus 로고
    • Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    • Kigerl, K.A., Gensel, J.C., Ankeny, D.P., Alexander, J.K., Donnelly, D.J., Popovich, P.G., Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J. Neurosci. 29 (2009), 13435–13444.
    • (2009) J. Neurosci. , vol.29 , pp. 13435-13444
    • Kigerl, K.A.1    Gensel, J.C.2    Ankeny, D.P.3    Alexander, J.K.4    Donnelly, D.J.5    Popovich, P.G.6
  • 69
    • 84901016368 scopus 로고    scopus 로고
    • ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS
    • e1225
    • Koch, J.C., Tonges, L., Barski, E., Michel, U., Bahr, M., Lingor, P., ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS. Cell death & disease, 5, 2014, e1225.
    • (2014) Cell death & disease , vol.5
    • Koch, J.C.1    Tonges, L.2    Barski, E.3    Michel, U.4    Bahr, M.5    Lingor, P.6
  • 70
    • 53249115158 scopus 로고    scopus 로고
    • Robust axonal growth and a blunted macrophage response are associated with impaired functional recovery after spinal cord injury in the MRL/MpJ mouse
    • Kostyk, S.K., Popovich, P.G., Stokes, B.T., Wei, P., Jakeman, L.B., Robust axonal growth and a blunted macrophage response are associated with impaired functional recovery after spinal cord injury in the MRL/MpJ mouse. Neuroscience 156 (2008), 498–514.
    • (2008) Neuroscience , vol.156 , pp. 498-514
    • Kostyk, S.K.1    Popovich, P.G.2    Stokes, B.T.3    Wei, P.4    Jakeman, L.B.5
  • 71
    • 79960943646 scopus 로고    scopus 로고
    • More than being protective: functional roles for TGF-beta/activin signaling pathways at central synapses
    • Krieglstein, K., Zheng, F., Unsicker, K., Alzheimer, C., More than being protective: functional roles for TGF-beta/activin signaling pathways at central synapses. Trends Neurosci. 34 (2011), 421–429.
    • (2011) Trends Neurosci. , vol.34 , pp. 421-429
    • Krieglstein, K.1    Zheng, F.2    Unsicker, K.3    Alzheimer, C.4
  • 72
    • 84908028367 scopus 로고    scopus 로고
    • TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord
    • Kroner, A., Greenhalgh, A.D., Zarruk, J.G., Passos Dos Santos, R., Gaestel, M., David, S., TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. Neuron 83 (2014), 1098–1116.
    • (2014) Neuron , vol.83 , pp. 1098-1116
    • Kroner, A.1    Greenhalgh, A.D.2    Zarruk, J.G.3    Passos Dos Santos, R.4    Gaestel, M.5    David, S.6
  • 73
    • 0029155706 scopus 로고
    • Inducible gene targeting in mice
    • Kuhn, R., Schwenk, F., Aguet, M., Rajewsky, K., Inducible gene targeting in mice. Science 269 (1995), 1427–1429.
    • (1995) Science , vol.269 , pp. 1427-1429
    • Kuhn, R.1    Schwenk, F.2    Aguet, M.3    Rajewsky, K.4
  • 76
    • 0033615538 scopus 로고    scopus 로고
    • Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
    • Lee, J.O., Yang, H., Georgescu, M.M., Di Cristofano, A., Maehama, T., Shi, Y., Dixon, J.E., Pandolfi, P., Pavletich, N.P., Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99 (1999), 323–334.
    • (1999) Cell , vol.99 , pp. 323-334
    • Lee, J.O.1    Yang, H.2    Georgescu, M.M.3    Di Cristofano, A.4    Maehama, T.5    Shi, Y.6    Dixon, J.E.7    Pandolfi, P.8    Pavletich, N.P.9
  • 77
    • 77956217610 scopus 로고    scopus 로고
    • Combined genetic attenuation of myelin and semaphorin-mediated growth inhibition is insufficient to promote serotonergic axon regeneration
    • Lee, J.K., Chow, R., Xie, F., Chow, S.Y., Tolentino, K.E., Zheng, B., Combined genetic attenuation of myelin and semaphorin-mediated growth inhibition is insufficient to promote serotonergic axon regeneration. J. Neurosci. 30 (2010), 10899–10904.
    • (2010) J. Neurosci. , vol.30 , pp. 10899-10904
    • Lee, J.K.1    Chow, R.2    Xie, F.3    Chow, S.Y.4    Tolentino, K.E.5    Zheng, B.6
  • 78
    • 33947702502 scopus 로고    scopus 로고
    • Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice
    • Li, Y., Semaan, S.J., Schlamp, C.L., Nickells, R.W., Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice. BMC Neurosci., 8, 2007, 19.
    • (2007) BMC Neurosci. , vol.8 , pp. 19
    • Li, Y.1    Semaan, S.J.2    Schlamp, C.L.3    Nickells, R.W.4
  • 83
    • 79959897174 scopus 로고    scopus 로고
    • Neuronal intrinsic mechanisms of axon regeneration
    • Liu, K., Tedeschi, A., Park, K.K., He, Z., Neuronal intrinsic mechanisms of axon regeneration. Annu. Rev. Neurosci. 34 (2011), 131–152.
    • (2011) Annu. Rev. Neurosci. , vol.34 , pp. 131-152
    • Liu, K.1    Tedeschi, A.2    Park, K.K.3    He, Z.4
  • 85
    • 84897560216 scopus 로고    scopus 로고
    • Axonal growth and connectivity from neural stem cell grafts in models of spinal cord injury
    • Lu, P., Kadoya, K., Tuszynski, M.H., Axonal growth and connectivity from neural stem cell grafts in models of spinal cord injury. Curr. Opin. Neurobiol. 27 (2014), 103–109.
    • (2014) Curr. Opin. Neurobiol. , vol.27 , pp. 103-109
    • Lu, P.1    Kadoya, K.2    Tuszynski, M.H.3
  • 86
    • 84961218614 scopus 로고    scopus 로고
    • GENETICS. A copy-and-paste gene regulatory network
    • Lynch, V.J., GENETICS. A copy-and-paste gene regulatory network. Science 351 (2016), 1029–1030.
    • (2016) Science , vol.351 , pp. 1029-1030
    • Lynch, V.J.1
  • 87
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma, X.M., Blenis, J., Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell Biol. 10 (2009), 307–318.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 88
    • 2642536916 scopus 로고    scopus 로고
    • Enhanced axonal growth into a spinal cord contusion injury site in a strain of mouse (129 × 1/SvJ) with a diminished inflammatory response
    • Ma, M., Wei, P., Wei, T., Ransohoff, R.M., Jakeman, L.B., Enhanced axonal growth into a spinal cord contusion injury site in a strain of mouse (129 × 1/SvJ) with a diminished inflammatory response. J. Comp. Neurol. 474 (2004), 469–486.
    • (2004) J. Comp. Neurol. , vol.474 , pp. 469-486
    • Ma, M.1    Wei, P.2    Wei, T.3    Ransohoff, R.M.4    Jakeman, L.B.5
  • 90
    • 72049112040 scopus 로고    scopus 로고
    • Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds
    • Madigan, N.N., McMahon, S., O'Brien, T., Yaszemski, M.J., Windebank, A.J., Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds. Respir. Physiol. Neurobiol. 169 (2009), 183–199.
    • (2009) Respir. Physiol. Neurobiol. , vol.169 , pp. 183-199
    • Madigan, N.N.1    McMahon, S.2    O'Brien, T.3    Yaszemski, M.J.4    Windebank, A.J.5
  • 92
    • 38649124935 scopus 로고    scopus 로고
    • Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3
    • Massey, J.M., Amps, J., Viapiano, M.S., Matthews, R.T., Wagoner, M.R., Whitaker, C.M., Alilain, W., Yonkof, A.L., Khalyfa, A., Cooper, N.G., Silver, J., Onifer, S.M., Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3. Exp. Neurol. 209 (2008), 426–445.
    • (2008) Exp. Neurol. , vol.209 , pp. 426-445
    • Massey, J.M.1    Amps, J.2    Viapiano, M.S.3    Matthews, R.T.4    Wagoner, M.R.5    Whitaker, C.M.6    Alilain, W.7    Yonkof, A.L.8    Khalyfa, A.9    Cooper, N.G.10    Silver, J.11    Onifer, S.M.12
  • 93
    • 84862773330 scopus 로고    scopus 로고
    • Neurotrophic factors in combinatorial approaches for spinal cord regeneration
    • McCall, J., Weidner, N., Blesch, A., Neurotrophic factors in combinatorial approaches for spinal cord regeneration. Cell Tissue Res. 349 (2012), 27–37.
    • (2012) Cell Tissue Res. , vol.349 , pp. 27-37
    • McCall, J.1    Weidner, N.2    Blesch, A.3
  • 94
    • 0002781574 scopus 로고
    • Versuche über Pflanzen-Hybriden. Verhandlungen des naturforschenden Vereines in Brünn, Bd IV für das Jahr 1865
    • Mendel, G.J., Versuche über Pflanzen-Hybriden. Verhandlungen des naturforschenden Vereines in Brünn, Bd IV für das Jahr 1865. Abhand-lungen, 1866, 3–47.
    • (1866) Abhand-lungen , pp. 3-47
    • Mendel, G.J.1
  • 95
    • 34548684100 scopus 로고    scopus 로고
    • GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord
    • Mills, C.D., Allchorne, A.J., Griffin, R.S., Woolf, C.J., Costigan, M., GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord. Mol. Cell. Neurosci. 36 (2007), 185–194.
    • (2007) Mol. Cell. Neurosci. , vol.36 , pp. 185-194
    • Mills, C.D.1    Allchorne, A.J.2    Griffin, R.S.3    Woolf, C.J.4    Costigan, M.5
  • 98
    • 84943820952 scopus 로고    scopus 로고
    • Informatics resources for the collaborative cross and related mouse populations
    • Morgan, A.P., Welsh, C.E., Informatics resources for the collaborative cross and related mouse populations. Mamm. Genome 26 (2015), 521–539.
    • (2015) Mamm. Genome , vol.26 , pp. 521-539
    • Morgan, A.P.1    Welsh, C.E.2
  • 101
    • 0033137077 scopus 로고    scopus 로고
    • Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury
    • Neumann, S., Woolf, C.J., Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury. Neuron 23 (1999), 83–91.
    • (1999) Neuron , vol.23 , pp. 83-91
    • Neumann, S.1    Woolf, C.J.2
  • 103
    • 84870875424 scopus 로고    scopus 로고
    • The harmonies played by TGF-beta in stem cell biology
    • Oshimori, N., Fuchs, E., The harmonies played by TGF-beta in stem cell biology. Cell Stem Cell 11 (2012), 751–764.
    • (2012) Cell Stem Cell , vol.11 , pp. 751-764
    • Oshimori, N.1    Fuchs, E.2
  • 104
    • 79956349096 scopus 로고    scopus 로고
    • Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons
    • Parikh, P., Hao, Y., Hosseinkhani, M., Patil, S.B., Huntley, G.W., Tessier-Lavigne, M., Zou, H., Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), E99–107.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. E99-107
    • Parikh, P.1    Hao, Y.2    Hosseinkhani, M.3    Patil, S.B.4    Huntley, G.W.5    Tessier-Lavigne, M.6    Zou, H.7
  • 107
    • 80053563664 scopus 로고    scopus 로고
    • Platelet-derived growth factor-responsive neural precursors give rise to myelinating oligodendrocytes after transplantation into the spinal cords of contused rats and dysmyelinated mice
    • Plemel, J.R., Chojnacki, A., Sparling, J.S., Liu, J., Plunet, W., Duncan, G.J., Park, S.E., Weiss, S., Tetzlaff, W., Platelet-derived growth factor-responsive neural precursors give rise to myelinating oligodendrocytes after transplantation into the spinal cords of contused rats and dysmyelinated mice. Glia 59 (2011), 1891–1910.
    • (2011) Glia , vol.59 , pp. 1891-1910
    • Plemel, J.R.1    Chojnacki, A.2    Sparling, J.S.3    Liu, J.4    Plunet, W.5    Duncan, G.J.6    Park, S.E.7    Weiss, S.8    Tetzlaff, W.9
  • 108
    • 43949114888 scopus 로고    scopus 로고
    • Can the immune system be harnessed to repair the CNS?
    • Popovich, P.G., Longbrake, E.E., Can the immune system be harnessed to repair the CNS?. Nat. Rev. Neurosci. 9 (2008), 481–493.
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 481-493
    • Popovich, P.G.1    Longbrake, E.E.2
  • 110
    • 0021220983 scopus 로고
    • Peripheral injury enhances central regeneration of primary sensory neurones
    • Richardson, P.M., Issa, V.M., Peripheral injury enhances central regeneration of primary sensory neurones. Nature 309 (1984), 791–793.
    • (1984) Nature , vol.309 , pp. 791-793
    • Richardson, P.M.1    Issa, V.M.2
  • 111
    • 0034753463 scopus 로고    scopus 로고
    • Mouse-based phenogenomics for modelling human disease
    • Rossant, J., McKerlie, C., Mouse-based phenogenomics for modelling human disease. Trends Mol. Med. 7 (2001), 502–507.
    • (2001) Trends Mol. Med. , vol.7 , pp. 502-507
    • Rossant, J.1    McKerlie, C.2
  • 112
    • 84859905286 scopus 로고    scopus 로고
    • Cell-based transplantation strategies to promote plasticity following spinal cord injury
    • Ruff, C.A., Wilcox, J.T., Fehlings, M.G., Cell-based transplantation strategies to promote plasticity following spinal cord injury. Exp. Neurol. 235 (2012), 78–90.
    • (2012) Exp. Neurol. , vol.235 , pp. 78-90
    • Ruff, C.A.1    Wilcox, J.T.2    Fehlings, M.G.3
  • 115
    • 84895950053 scopus 로고    scopus 로고
    • Nogo limits neural plasticity and recovery from injury
    • Schwab, M.E., Strittmatter, S.M., Nogo limits neural plasticity and recovery from injury. Curr. Opin. Neurobiol. 27 (2014), 53–60.
    • (2014) Curr. Opin. Neurobiol. , vol.27 , pp. 53-60
    • Schwab, M.E.1    Strittmatter, S.M.2
  • 116
    • 84894477091 scopus 로고    scopus 로고
    • Congenic fine-mapping identifies a major causal locus for variation in the native collateral circulation and ischemic injury in brain and lower extremity
    • Sealock, R., Zhang, H., Lucitti, J.L., Moore, S.M., Faber, J.E., Congenic fine-mapping identifies a major causal locus for variation in the native collateral circulation and ischemic injury in brain and lower extremity. Circ. Res. 114 (2014), 660–671.
    • (2014) Circ. Res. , vol.114 , pp. 660-671
    • Sealock, R.1    Zhang, H.2    Lucitti, J.L.3    Moore, S.M.4    Faber, J.E.5
  • 117
    • 0035129566 scopus 로고    scopus 로고
    • Retinal ganglion cell and nonneuronal cell responses to a microcrush lesion of adult rat optic nerve
    • Selles-Navarro, I., Ellezam, B., Fajardo, R., Latour, M., McKerracher, L., Retinal ganglion cell and nonneuronal cell responses to a microcrush lesion of adult rat optic nerve. Exp. Neurol. 167 (2001), 282–289.
    • (2001) Exp. Neurol. , vol.167 , pp. 282-289
    • Selles-Navarro, I.1    Ellezam, B.2    Fajardo, R.3    Latour, M.4    McKerracher, L.5
  • 119
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi, Y., Massague, J., Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113 (2003), 685–700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 120
    • 0742288565 scopus 로고    scopus 로고
    • Regeneration beyond the glial scar
    • Silver, J., Miller, J.H., Regeneration beyond the glial scar. Nat. Rev. Neurosci. 5 (2004), 146–156.
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 146-156
    • Silver, J.1    Miller, J.H.2
  • 121
    • 84924788126 scopus 로고    scopus 로고
    • Central nervous system regenerative failure: role of oligodendrocytes, astrocytes, and microglia
    • Silver, J., Schwab, M.E., Popovich, P.G., Central nervous system regenerative failure: role of oligodendrocytes, astrocytes, and microglia. Cold Spring Harb. Perspect. Biol., 7, 2015, a020602.
    • (2015) Cold Spring Harb. Perspect. Biol. , vol.7 , pp. a020602
    • Silver, J.1    Schwab, M.E.2    Popovich, P.G.3
  • 122
    • 0031029782 scopus 로고    scopus 로고
    • A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth
    • Smith, D.S., Skene, J.H., A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth. J. Neurosci. 17 (1997), 646–658.
    • (1997) J. Neurosci. , vol.17 , pp. 646-658
    • Smith, D.S.1    Skene, J.H.2
  • 123
    • 0025267918 scopus 로고
    • Maturation of astrocytes in vitro alters the extent and molecular basis of neurite outgrowth
    • Smith, G.M., Rutishauser, U., Silver, J., Miller, R.H., Maturation of astrocytes in vitro alters the extent and molecular basis of neurite outgrowth. Dev. Biol. 138 (1990), 377–390.
    • (1990) Dev. Biol. , vol.138 , pp. 377-390
    • Smith, G.M.1    Rutishauser, U.2    Silver, J.3    Miller, R.H.4
  • 124
    • 37349052866 scopus 로고    scopus 로고
    • Inhibition of activin/nodal signaling promotes specification of human embryonic stem cells into neuroectoderm
    • Smith, J.R., Vallier, L., Lupo, G., Alexander, M., Harris, W.A., Pedersen, R.A., Inhibition of activin/nodal signaling promotes specification of human embryonic stem cells into neuroectoderm. Dev. Biol. 313 (2008), 107–117.
    • (2008) Dev. Biol. , vol.313 , pp. 107-117
    • Smith, J.R.1    Vallier, L.2    Lupo, G.3    Alexander, M.4    Harris, W.A.5    Pedersen, R.A.6
  • 127
    • 77950482298 scopus 로고    scopus 로고
    • A mouse model of lethal infection for evaluating prophylactics and therapeutics against monkeypox virus
    • Stabenow, J., Buller, R.M., Schriewer, J., West, C., Sagartz, J.E., Parker, S., A mouse model of lethal infection for evaluating prophylactics and therapeutics against monkeypox virus. J. Virol. 84 (2010), 3909–3920.
    • (2010) J. Virol. , vol.84 , pp. 3909-3920
    • Stabenow, J.1    Buller, R.M.2    Schriewer, J.3    West, C.4    Sagartz, J.E.5    Parker, S.6
  • 129
    • 84907982779 scopus 로고    scopus 로고
    • Characterization of ectopic colonies that form in widespread areas of the nervous system with neural stem cell transplants into the site of a severe spinal cord injury
    • Steward, O., Sharp, K.G., Yee, K.M., Hatch, M.N., Bonner, J.F., Characterization of ectopic colonies that form in widespread areas of the nervous system with neural stem cell transplants into the site of a severe spinal cord injury. J. Neurosci. 34 (2014), 14013–14021.
    • (2014) J. Neurosci. , vol.34 , pp. 14013-14021
    • Steward, O.1    Sharp, K.G.2    Yee, K.M.3    Hatch, M.N.4    Bonner, J.F.5
  • 132
    • 0037646520 scopus 로고    scopus 로고
    • Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways
    • Subramaniam, S., Strelau, J., Unsicker, K., Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways. J. Biol. Chem. 278 (2003), 8904–8912.
    • (2003) J. Biol. Chem. , vol.278 , pp. 8904-8912
    • Subramaniam, S.1    Strelau, J.2    Unsicker, K.3
  • 133
    • 74049158590 scopus 로고    scopus 로고
    • Novel potassium channel blocker, 4-AP-3-MeOH, inhibits fast potassium channels and restores axonal conduction in injured guinea pig spinal cord white matter
    • Sun, W., Smith, D., Fu, Y., Cheng, J.X., Bryn, S., Borgens, R., Shi, R., Novel potassium channel blocker, 4-AP-3-MeOH, inhibits fast potassium channels and restores axonal conduction in injured guinea pig spinal cord white matter. J. Neurophysiol. 103 (2010), 469–478.
    • (2010) J. Neurophysiol. , vol.103 , pp. 469-478
    • Sun, W.1    Smith, D.2    Fu, Y.3    Cheng, J.X.4    Bryn, S.5    Borgens, R.6    Shi, R.7
  • 136
    • 70349269509 scopus 로고    scopus 로고
    • Considering the evolution of regeneration in the central nervous system
    • Tanaka, E.M., Ferretti, P., Considering the evolution of regeneration in the central nervous system. Nat. Rev. Neurosci. 10 (2009), 713–723.
    • (2009) Nat. Rev. Neurosci. , vol.10 , pp. 713-723
    • Tanaka, E.M.1    Ferretti, P.2
  • 139
    • 84856812429 scopus 로고    scopus 로고
    • Enhanced functional recovery in MRL/MpJ mice after spinal cord dorsal hemisection
    • e30904
    • Thuret, S., Thallmair, M., Horky, L.L., Gage, F.H., Enhanced functional recovery in MRL/MpJ mice after spinal cord dorsal hemisection. PLoS One, 7, 2012, e30904.
    • (2012) PLoS One , vol.7
    • Thuret, S.1    Thallmair, M.2    Horky, L.L.3    Gage, F.H.4
  • 140
    • 0033927181 scopus 로고    scopus 로고
    • Induction of activin A is essential for the neuroprotective action of basic fibroblast growth factor in vivo
    • Tretter, Y.P., Hertel, M., Munz, B., ten Bruggencate, G., Werner, S., Alzheimer, C., Induction of activin A is essential for the neuroprotective action of basic fibroblast growth factor in vivo. Nat. Med. 6 (2000), 812–815.
    • (2000) Nat. Med. , vol.6 , pp. 812-815
    • Tretter, Y.P.1    Hertel, M.2    Munz, B.3    ten Bruggencate, G.4    Werner, S.5    Alzheimer, C.6
  • 142
    • 14244262504 scopus 로고    scopus 로고
    • Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway
    • Vallier, L., Reynolds, D., Pedersen, R.A., Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway. Dev. Biol. 275 (2004), 403–421.
    • (2004) Dev. Biol. , vol.275 , pp. 403-421
    • Vallier, L.1    Reynolds, D.2    Pedersen, R.A.3
  • 143
    • 0027463379 scopus 로고
    • Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats
    • Villegas-Perez, M.P., Vidal-Sanz, M., Rasminsky, M., Bray, G.M., Aguayo, A.J., Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats. J. Neurobiol. 24 (1993), 23–36.
    • (1993) J. Neurobiol. , vol.24 , pp. 23-36
    • Villegas-Perez, M.P.1    Vidal-Sanz, M.2    Rasminsky, M.3    Bray, G.M.4    Aguayo, A.J.5
  • 144
    • 27644585884 scopus 로고    scopus 로고
    • Genetic variation in laboratory mice
    • Wade, C.M., Daly, M.J., Genetic variation in laboratory mice. Nat. Genet. 37 (2005), 1175–1180.
    • (2005) Nat. Genet. , vol.37 , pp. 1175-1180
    • Wade, C.M.1    Daly, M.J.2
  • 145
    • 79960918614 scopus 로고    scopus 로고
    • TGF-beta signaling is required for maintenance of retinal ganglion cell differentiation and survival
    • Walshe, T.E., Leach, L.L., D'Amore, P.A., TGF-beta signaling is required for maintenance of retinal ganglion cell differentiation and survival. Neuroscience 189 (2011), 123–131.
    • (2011) Neuroscience , vol.189 , pp. 123-131
    • Walshe, T.E.1    Leach, L.L.2    D'Amore, P.A.3
  • 146
    • 79959672790 scopus 로고    scopus 로고
    • Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury
    • Wang, D., Ichiyama, R.M., Zhao, R., Andrews, M.R., Fawcett, J.W., Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury. J. Neurosci. 31 (2011), 9332–9344.
    • (2011) J. Neurosci. , vol.31 , pp. 9332-9344
    • Wang, D.1    Ichiyama, R.M.2    Zhao, R.3    Andrews, M.R.4    Fawcett, J.W.5
  • 147
    • 84923040472 scopus 로고    scopus 로고
    • Overexpression of Sox11 promotes corticospinal tract regeneration after spinal injury while interfering with functional recovery
    • Wang, Z., Reynolds, A., Kirry, A., Nienhaus, C., Blackmore, M.G., Overexpression of Sox11 promotes corticospinal tract regeneration after spinal injury while interfering with functional recovery. J. Neurosci. 35 (2015), 3139–3145.
    • (2015) J. Neurosci. , vol.35 , pp. 3139-3145
    • Wang, Z.1    Reynolds, A.2    Kirry, A.3    Nienhaus, C.4    Blackmore, M.G.5
  • 149
    • 13544272671 scopus 로고    scopus 로고
    • Vessels and nerves: marching to the same tune
    • Weinstein, B.M., Vessels and nerves: marching to the same tune. Cell 120 (2005), 299–302.
    • (2005) Cell , vol.120 , pp. 299-302
    • Weinstein, B.M.1
  • 150
    • 0034674516 scopus 로고    scopus 로고
    • A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia
    • Wellons, J.C. 3rd, Sheng, H., Laskowitz, D.T., Mackensen, G.B., Pearlstein, R.D., Warner, D.S., A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia. Brain Res. 868 (2000), 14–21.
    • (2000) Brain Res. , vol.868 , pp. 14-21
    • Wellons, J.C.1    Sheng, H.2    Laskowitz, D.T.3    Mackensen, G.B.4    Pearlstein, R.D.5    Warner, D.S.6
  • 151
    • 84998944685 scopus 로고    scopus 로고
    • Activins in Reproductive Biology and Beyond
    • (Human reproduction update)
    • Wijayarathna, R., de Kretser, D.M., Activins in Reproductive Biology and Beyond. 2016 (Human reproduction update).
    • (2016)
    • Wijayarathna, R.1    de Kretser, D.M.2
  • 152
    • 3543107212 scopus 로고    scopus 로고
    • Fibrotic disease and the T(H)1/T(H)2 paradigm
    • Wynn, T.A., Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat. Rev. Immunol. 4 (2004), 583–594.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 583-594
    • Wynn, T.A.1
  • 153
  • 154
    • 84943457295 scopus 로고    scopus 로고
    • Viral vector-based improvement of optic nerve regeneration: characterization of individual axons' growth patterns and synaptogenesis in a visual target
    • Yungher, B.J., Luo, X., Salgueiro, Y., Blackmore, M.G., Park, K.K., Viral vector-based improvement of optic nerve regeneration: characterization of individual axons' growth patterns and synaptogenesis in a visual target. Gene Ther. 22 (2015), 811–821.
    • (2015) Gene Ther. , vol.22 , pp. 811-821
    • Yungher, B.J.1    Luo, X.2    Salgueiro, Y.3    Blackmore, M.G.4    Park, K.K.5
  • 155
    • 0037423389 scopus 로고    scopus 로고
    • TGF-beta signaling activates steroid hormone receptor expression during neuronal remodeling in the Drosophila brain
    • Zheng, X., Wang, J., Haerry, T.E., Wu, A.Y., Martin, J., O'Connor, M.B., Lee, C.H., Lee, T., TGF-beta signaling activates steroid hormone receptor expression during neuronal remodeling in the Drosophila brain. Cell 112 (2003), 303–315.
    • (2003) Cell , vol.112 , pp. 303-315
    • Zheng, X.1    Wang, J.2    Haerry, T.E.3    Wu, A.Y.4    Martin, J.5    O'Connor, M.B.6    Lee, C.H.7    Lee, T.8
  • 156
    • 84884545941 scopus 로고    scopus 로고
    • Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury
    • Zukor, K., Belin, S., Wang, C., Keelan, N., Wang, X., He, Z., Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury. J. Neurosci. 33 (2013), 15350–15361.
    • (2013) J. Neurosci. , vol.33 , pp. 15350-15361
    • Zukor, K.1    Belin, S.2    Wang, C.3    Keelan, N.4    Wang, X.5    He, Z.6


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