Regulatory evolution of innate immunity through co-option of endogenous retroviruses

Science

Volumn 351, Issue 6277, 2016, Pages 1083-1087

  Chuong, Edward B ^a   Elde, Nels C ^a   Feschotte, Cédric ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 1; STAT1 PROTEIN; TRANSCRIPTION FACTOR; AIM2 PROTEIN, HUMAN; DNA BINDING PROTEIN; INFLAMMASOME;

EVOLUTION; GENE EXPRESSION; GENOME; IMMUNITY; INNATE BEHAVIOR; INNOVATION; MAMMAL; VIRUS;

ARTICLE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CRISPR CAS SYSTEM; ENDOGENOUS RETROVIRUS; FIBROBLAST; GAMMARETROVIRUS; HELA CELL LINE; HUMAN; HUMAN GENOME; INNATE IMMUNITY; LONG TERMINAL REPEAT; LUCIFERASE ASSAY; MOLECULAR EVOLUTION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; TRANSIENT TRANSFECTION; ANIMAL; ENHANCER REGION; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; IMMUNOLOGY; PHYSIOLOGY;

MAMMALIA;

ANIMALS; DNA-BINDING PROTEINS; ENDOGENOUS RETROVIRUSES; ENHANCER ELEMENTS, GENETIC; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENOME, HUMAN; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; INTERFERON-GAMMA;

EID: 84960194716     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad5497     Document Type: Article

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