TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

Neuron

Volumn 83, Issue 5, 2014, Pages 1098-1116

  Kroner, Antje ^a   Greenhalgh, Andrew D ^a   Zarruk, Juan G ^a   PassosdosSantos, Rosmarini ^a   Gaestel, Matthias ^b   David, Samuel ^a  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; MYELIN; TUMOR NECROSIS FACTOR; CYTOKINE; GREEN FLUORESCENT PROTEIN; MAP KINASE ACTIVATED KINASE 2; MAP-KINASE-ACTIVATED KINASE 2; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL LEVEL; CELL POPULATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CONVALESCENCE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LETHALITY; MACROPHAGE FUNCTION; MACROPHAGE POLARIZATION; MOUSE; NERVE FIBER GROWTH; NONHUMAN; PHAGOCYTOSIS; POLARIZATION; PROTEIN EXPRESSION; SPINAL CORD INJURY; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL PROTECTION; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INTRACELLULAR FLUID; MACROPHAGE; METABOLISM; MICROGLIA; MYELIN SHEATH; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; TIME; TRANSGENIC MOUSE; TRANSPLANTATION;

ANIMALS; APOPTOSIS; CYTOKINES; CYTOPROTECTION; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; INTRACELLULAR FLUID; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; IRON; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; MYELIN SHEATH; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; SPINAL CORD INJURIES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84908028367     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.07.027     Document Type: Article

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