Induction of activin A is essential for the neuroprotective action of basic fibroblast growth factor in vivo

Nature Medicine

Volumn 6, Issue 7, 2000, Pages 812-815

  Tretter, Yvonne P ^a   Hertel, Moritz ^b,c   Munz, Barbara ^b,d   Bruggencate, Gerrit Ten ^a   Werner, Sabine ^b,c   Alzheimer, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c ETH ZURICH   (Switzerland)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; BASIC FIBROBLAST GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; DRUG USE; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROKE;

ACTIVINS; ANIMALS; BRAIN; FIBROBLAST GROWTH FACTOR 2; GROWTH SUBSTANCES; HIPPOCAMPUS; INHIBINS; KAINIC ACID; MALE; MICE; MICE, INBRED C57BL; NEURONS; NEUROPROTECTIVE AGENTS;

ANIMALIA;

EID: 0033927181     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/77548     Document Type: Article

References (25)

1. Ay, H., Ay, I., Koroshetz, W.J. & Finklestein, S.P. Potential usefulness of basic fibroblast growth factor as a treatment for stroke. Cerebrovasc. Dis. 9, 131-135 (1999).
2. Bethel, A., Kirsch, J.R., Koehler, R.C., Finklestein, S.P. & Traystman, R.J. Intravenous basic fibroblast growth factor decreases brain injury resulting from focal ischemia in cats. Stroke 28, 609-615 (1997).
3. Kirschner, P.B. et al. Basic fibroblast growth factor protects against excitotoxicity and chemical hypoxia in both neonatal and adult rats. J. Cereb. Blood flow Metab. 15, 619-623 (1995).
4. Anderson, K.J., Dam, D. Lee, S. & Cotman, C.W. Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo. Nature 332, 360-361 (1988).
5. Peterson, D.A., Lucidi-Phillipi, C.A., Murphy, D.P. Ray, J. & Gage, F.H. Fibroblast growth factor-2 protects entorhinal layer II glutamatergic neurons from axotomy-induced death. J. Neurosci. 16, 886-898 (1996).
6. Nadler, J.V., Perry, B.W., Gentry, C. & Cotman, C.W. Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid. J. Camp. Neurol. 192, 333-359 (1980).
7. Tretter, Y.P. et al. Strong induction of activin expression after hippocampal lesion. Neuroreport 7, 1819-1823 (1996).
8. Munz, B., Hübner, G., Tretter, Y., Alzheimer, C. & Werner, S. A novel role of activin in inflammation and repair. J. Endocrinol. 161, 187-193 (1999).
9. McDowell, N., Zorn, A.M., Crease, D.J. & Gurdon, J.B. Activin has direct long-range signaling activity and can form a concentration gradient by diffusion. Curr. Biol. 7, 671-681 (1997).
10. Munz, B. et al. Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair. EMBO J. 18, 5205-5215 (1999).
11. + toxicity. EMBO J. 14, 736-742 (1995).
12. Wu, D.D. et al. Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic-ischemic brain injury in the infant rat. Brain Res. 835, 369-378 (1999).
13. Hughes, P.E., Alexi, T., Williams, C.E., Clark, R.G. & Gluckman, P.D. Administration of recombinant human activin-A has powerful neurotrophic effect on select striatal phenotypes in the quinolinic acid lesion model of Huntington's disease. Neuroscience 92, 197-209 (1999).
14. Nakamura, T. et al. Activin-binding protein from rat ovary is follistatin. Science 247, 836-838 (1990).
15. de Winter, J.P. et al. Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors. Mol. Cell. Endocrinol. 116, 105-114 (1996).
16. Lai, M., Gluckman, P., Dragunow, M. & Hughes, P.E. Focal brain injury increases activin βA mRNA expression in hippocampal neurons. Neuroreport 8, 2691-2694 (1997).
17. Riva, M.A., Donati, E., Tascedda, F., Zolli, M. & Racagni, G. Short-and long-term induction of basic fibroblast growth factor gene expression in rat central nervous system following kainate injection. Neuroscience 59, 55-65 (1994).
18. Fainsod, A. et al. The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4. Mech. Dev. 63, 39-50 (1997).
19. Iemura, S.-I. et al. Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo. Proc. Natl. Acad. Sci. USA 95, 9337-9342 (1998).
20. Sugino, H., Sugino, K., Hashimoto, O., Shoji, H. & Nakamura, T. Follistatin and its role as an activin-binding protein. J. Med. Invest. 44, 1-14 (1997).
21. Krieglstein, K., Reuss, B., Maysinger, D. & Unsicker K. Transforming growth factor-β mediates the neurotrophic effect of fibroblast growth factor-2 on midbrain dopaminergic neurons. Eur. J. Neurosci. 10, 2746-2750 (1998).
22. Yasuda, H. et al. Activin A: An autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes. J. Clin. Invest. 92, 1491-1496 (1993).
23. Werner, S. et al. Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation. EMBO J. 12, 2635-2643 (1993).
24. Wisden, W., Morris, B.J. & Hunt, S.P. in Molecular Neurobiology - A Practical Approach (eds. Chad, J. & Wheal, H.) 205-225 (Oxford University Press, New York, 1991).
25. Hübner, G. & Werner, S. Serum growth factors and proinflammatory cytokines are potent inducers of activin expression in cultured keratinocytes. Exp. Cell Res. 228, 106-113 (1996).