Functional regeneration of respiratory pathways after spinal cord injury

Nature

Volumn 475, Issue 7355, 2011, Pages 196-200

  Alilain, Warren J ^a   Horn, Kevin P ^a   Hu, Hongmei ^a   Dick, Thomas E ^a   Silver, Jerry ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN SULPHATE PROTEOGLYCAN; PROTEOGLYCAN; UNCLASSIFIED DRUG;

EXPERIMENTAL STUDY; INHIBITOR; INJURY; NERVOUS SYSTEM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; DIAPHRAGM; DIAPHRAGM MUSCLE; DIAPHRAGM PARALYSIS; ELECTROMYOGRAPHY; ENZYME DEGRADATION; FEMALE; MOTOR NERVE; MOUSE; NERVE CELL PLASTICITY; NERVE FIBER; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; SPINAL CORD; SPINAL CORD INJURY; SPINAL CORD REGENERATION; UPREGULATION;

ANIMALS; AXONS; CHONDROITIN ABC LYASE; CHONDROITIN SULFATE PROTEOGLYCANS; DIAPHRAGM; DISEASE MODELS, ANIMAL; ELECTROMYOGRAPHY; EXTRACELLULAR MATRIX; NERVE NET; NERVE REGENERATION; NEURONAL PLASTICITY; PHRENIC NERVE; RATS; RESPIRATION; SPINAL CORD INJURIES;

EID: 79960405675     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10199     Document Type: Article

References (32)

1. Davies, S. J. et al. Regeneration of adult axons in white matter tracts of the central nervous system. Nature 390, 680-683 (1997). (Pubitemid 28016354)
2. Silver, J. & Miller, J. H. Regeneration beyond the glial scar. Nature Rev. Neurosci. 5, 146-156 (2004).
3. Massey, J. M. et al. ChondroitinaseABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury. J. Neurosci. 26, 4406-4414 (2006). (Pubitemid 44315399)
4. García-Alias, G., Barkhuysen, S., Buckle, M. & Fawcett, J. W. Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation. Nature Neurosci. 12, 1145-1151 (2009).
5. Hunanyan, A. S. et al. Role of chondroitin sulfate proteoglycans in axonal conduction in mammalian spinal cord. J. Neurosci. 30, 7761-7769 (2010).
6. Schachtrup, C. et al. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-b after vascular damage. J. Neurosci. 30, 5843-5854 (2010).
7. Choi, H. et al. Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious rats. J. Neurosci. 25, 4550-4559 (2005). (Pubitemid 40629145)
8. Fuller, D. D. et al. Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptors. J. Neurotrauma 22, 203-213 (2005). (Pubitemid 40333515)
9. Golder, F. J. & Mitchell, G. S. Spinal synaptic enhancement with acute intermittent hypoxia improves respiratory function after chronic cervical spinal cord injury. J. Neurosci. 25, 2925-2932 (2005). (Pubitemid 40389250)
10. Goshgarian, H. G. The crossed phrenic phenomenon: a model for plasticity in the respiratory pathways following spinal cord injury. J. Appl. Physiol. 94, 795-810 (2003).
11. Hadley, S. D., Walker, P. D. & Goshgarian, H. G. Effects of the serotonin synthesis inhibitor p-CPA on the expression of the crossed phrenic phenomenon 4 h following C2 spinal cord hemisection. Exp. Neurol. 160, 479-488 (1999).
12. Hodges, M. R. et al. Defects in breathing and thermoregulation in mice with nearcomplete absence of central serotonin neurons. J. Neurosci. 28, 2495-2505 (2008). (Pubitemid 351348199)
13. David, S. & Aguayo, A. J. Axonal elongation into peripheral nervous system 'bridges' after central nervous system injury in adult rats. Science 214, 931-933 (1981). (Pubitemid 12220099)
14. Munz, M. et al. Functional activity of rat brainstem neurons regenerating axons along peripheral nerve grafts. Brain Res. 340, 115-125 (1985). (Pubitemid 15233357)
15. Gauthier, P. & Rasminsky, M. Activity of medullary respiratory neurons regenerating axons into peripheral nerve grafts in the adult rat. Brain Res. 438, 225-236 (1988). (Pubitemid 18016824)
16. Gauthier, P. et al. Functional reconnections established by central respiratory neurons regenerating axons into a nerve graft bridging the respiratory centers to the cervical spinal cord. J. Neurosci. Res. 70, 65-81 (2002).
17. Fouad, K. et al. Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. J. Neurosci. 25, 1169-1178 (2005). (Pubitemid 40268958)
18. Houle, J. D. et al. Combining an autologous peripheral nervous system'bridge' and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord. J. Neurosci. 26, 7405-7415 (2006). (Pubitemid 44315209)
19. Yang, L. J. et al. Sialidase enhances spinal axon outgrowth in vivo. Proc. Natl Acad. Sci. USA 103, 11057-11062 (2006).
20. Zhou, L., Baumgartner, B. J., Hill-Felberg, S. J., McGowen, L. R. & Shine, H. D. Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord. J. Neurosci. 23, 1424-1431 (2003). (Pubitemid 36258921)
21. Alto, L. T. et al. Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nature Neurosci. 12, 1106-1113 (2009).
22. Liu, K. et al. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nature Neurosci. 13, 1075-1081 (2010).
23. McPhail, L. T., Plunet, W. T., Das, P. & Ramer, M. S. The astrocytic barrier to axonal regeneration at the dorsal root entry zone is induced by rhizotomy. Eur. J. Neurosci. 21, 267-270 (2005).
24. Hayashi, F., Hinrichsen, C. F. & McCrimmon, D. R. Short-term plasticity of descending synaptic input to phrenic motoneurons in rats. J. Appl. Physiol. 94, 1421-1430 (2003).
25. Lane, M. A. et al. Cervical prephrenic interneurons in the normal and lesioned spinal cord of the adult rat. J. Comp. Neurol. 511, 692-709 (2008).
26. Turrigiano, G. G. & Nelson, S. B. Homeostatic plasticity in the developing nervous system. Nature Rev. Neurosci. 5, 97-107 (2004).
27. Nantwi, K. D., El-Bohy, A. & Goshgarian, H. G. Actions of systemic theophylline on hemidiaphragmatic recovery in rats following cervical spinal cord hemisection. Exp. Neurol. 140, 53-59 (1996).
28. Fuller, D. D., Johnson, S. M., Olson, E. B. Jr & Mitchell, G. S. Synaptic pathways to phrenic motoneurons are enhanced by chronic intermittent hypoxia after cervical spinal cord injury. J. Neurosci. 23, 2993-3000 (2003). (Pubitemid 36418635)
29. Teng, Y. D. et al. Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats. J. Neurosci. 23, 4182-4189 (2003). (Pubitemid 36958438)
30. Alilain, W. J. et al. Light-induced rescue of breathing after spinal cord injury. J. Neurosci. 28, 11862-11870 (2008).
31. Houle, J. D. et al. Combining peripheral nerve grafting and matrix modulation to repair the injured rat spinal cord. J. Vis. Exp. doi:10.3791/1324 (2009).
32. Paxinos, G.& Watson C. The Rat Brain in Stereotaxic Coordinates (Academic 1998).