메뉴 건너뛰기




Volumn 18, Issue 3, 2008, Pages 276-283

Nerve injury signaling

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR SOX11; VOLTAGE GATED SODIUM CHANNEL;

EID: 53949112900     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.conb.2008.06.005     Document Type: Review
Times cited : (227)

References (64)
  • 1
    • 1342328010 scopus 로고    scopus 로고
    • Nogo and axon regeneration
    • Schwab M.E. Nogo and axon regeneration. Curr Opin Neurobiol 14 (2004) 118-124
    • (2004) Curr Opin Neurobiol , vol.14 , pp. 118-124
    • Schwab, M.E.1
  • 2
    • 0021220983 scopus 로고
    • Peripheral injury enhances central regeneration of primary sensory neurones
    • Richardson P.M., and Issa V.M. Peripheral injury enhances central regeneration of primary sensory neurones. Nature 309 (1984) 791-793
    • (1984) Nature , vol.309 , pp. 791-793
    • Richardson, P.M.1    Issa, V.M.2
  • 3
    • 0033137077 scopus 로고    scopus 로고
    • Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury
    • Neumann S., and Woolf C.J. Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury. Neuron 23 (1999) 83-91
    • (1999) Neuron , vol.23 , pp. 83-91
    • Neumann, S.1    Woolf, C.J.2
  • 4
    • 0030203658 scopus 로고    scopus 로고
    • Priming events and retrograde injury signals. A new perspective on the cellular and molecular biology of nerve regeneration
    • Ambron R.T., and Walters E.T. Priming events and retrograde injury signals. A new perspective on the cellular and molecular biology of nerve regeneration. Mol Neurobiol 13 (1996) 61-79
    • (1996) Mol Neurobiol , vol.13 , pp. 61-79
    • Ambron, R.T.1    Walters, E.T.2
  • 5
    • 0029152904 scopus 로고
    • Retrograde axonal transport of signal transduction proteins in rat sciatic nerve
    • Johanson S.O., Crouch M.F., and Hendry I.A. Retrograde axonal transport of signal transduction proteins in rat sciatic nerve. Brain Res 690 (1995) 55-63
    • (1995) Brain Res , vol.690 , pp. 55-63
    • Johanson, S.O.1    Crouch, M.F.2    Hendry, I.A.3
  • 6
    • 14644404885 scopus 로고    scopus 로고
    • Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve
    • The authors show that the intermediate filament vimentin is locally translated in sciatic nerve axoplasm following injury, and that the newly synthesized vimentin links activated MAP kinases Erk1 and Erk2 to the dynein motor retrograde motor complex. Importantly, they provide functional evidence for the role of vimentin in injury signaling by showing that neurite outgrowth in DRGs following a nerve-conditioning lesion is inhibited in vimentin null mice. They further find that the activation of Elk1, a downstream target of activated Erks, is impaired in these mice, suggesting that vimentin is necessary for retrograde transport of active Erk following injury.
    • Perlson E., Hanz S., Ben-Yaakov K., Segal-Ruder Y., Seger R., and Fainzilber M. Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron 45 (2005) 715-726. The authors show that the intermediate filament vimentin is locally translated in sciatic nerve axoplasm following injury, and that the newly synthesized vimentin links activated MAP kinases Erk1 and Erk2 to the dynein motor retrograde motor complex. Importantly, they provide functional evidence for the role of vimentin in injury signaling by showing that neurite outgrowth in DRGs following a nerve-conditioning lesion is inhibited in vimentin null mice. They further find that the activation of Elk1, a downstream target of activated Erks, is impaired in these mice, suggesting that vimentin is necessary for retrograde transport of active Erk following injury.
    • (2005) Neuron , vol.45 , pp. 715-726
    • Perlson, E.1    Hanz, S.2    Ben-Yaakov, K.3    Segal-Ruder, Y.4    Seger, R.5    Fainzilber, M.6
  • 8
    • 14744273901 scopus 로고    scopus 로고
    • Sunday Driver links axonal transport to damage signaling
    • The authors use biochemical, immunofluorescence, and EM techniques in the mouse sciatic nerve to show that syd mediates the axonal transport of vesicles and interact with both the anterograde motor kinesin and the retrograde motor complex dynein/dynactin. In response to sciatic nerve damage, JNK is locally activated within axons and syd preferentially interacts with the retrograde motor dynein/dynactin, resulting in increased syd and activated JNK retrograde transport.
    • Cavalli V., Kujala P., Klumperman J., and Goldstein L.S. Sunday Driver links axonal transport to damage signaling. J Cell Biol 168 (2005) 775-787. The authors use biochemical, immunofluorescence, and EM techniques in the mouse sciatic nerve to show that syd mediates the axonal transport of vesicles and interact with both the anterograde motor kinesin and the retrograde motor complex dynein/dynactin. In response to sciatic nerve damage, JNK is locally activated within axons and syd preferentially interacts with the retrograde motor dynein/dynactin, resulting in increased syd and activated JNK retrograde transport.
    • (2005) J Cell Biol , vol.168 , pp. 775-787
    • Cavalli, V.1    Kujala, P.2    Klumperman, J.3    Goldstein, L.S.4
  • 9
    • 19444385804 scopus 로고    scopus 로고
    • Retrograde axonal transport of JNK signaling molecules influence injury induced nuclear changes in p-c-Jun and ATF3 in adult rat sensory neurons
    • Lindwall C., and Kanje M. Retrograde axonal transport of JNK signaling molecules influence injury induced nuclear changes in p-c-Jun and ATF3 in adult rat sensory neurons. Mol Cell Neurosci 29 (2005) 269-282
    • (2005) Mol Cell Neurosci , vol.29 , pp. 269-282
    • Lindwall, C.1    Kanje, M.2
  • 10
    • 33746001390 scopus 로고    scopus 로고
    • Activation and retrograde transport of protein kinase G in rat nociceptive neurons after nerve injury and inflammation
    • Sung Y.J., Chiu D.T., and Ambron R.T. Activation and retrograde transport of protein kinase G in rat nociceptive neurons after nerve injury and inflammation. Neuroscience 141 (2006) 697-709
    • (2006) Neuroscience , vol.141 , pp. 697-709
    • Sung, Y.J.1    Chiu, D.T.2    Ambron, R.T.3
  • 11
    • 33751116969 scopus 로고    scopus 로고
    • Vimentin binding to phosphorylated erk sterically hinders enzymatic dephosphorylation of the kinase
    • This study is the first to show how scaffolding proteins protect activated kinases from dephosphorylation during retrograde transport. Through a series of elegant biochemical and molecular modeling experiments, the authors show that vimentin protects the phosphorylation site of Erk by calcium-dependent steric hindrance.
    • Perlson E., Michaelevski I., Kowalsman N., Ben-Yaakov K., Shaked M., Seger R., Eisenstein M., and Fainzilber M. Vimentin binding to phosphorylated erk sterically hinders enzymatic dephosphorylation of the kinase. J Mol Biol 364 (2006) 938-944. This study is the first to show how scaffolding proteins protect activated kinases from dephosphorylation during retrograde transport. Through a series of elegant biochemical and molecular modeling experiments, the authors show that vimentin protects the phosphorylation site of Erk by calcium-dependent steric hindrance.
    • (2006) J Mol Biol , vol.364 , pp. 938-944
    • Perlson, E.1    Michaelevski, I.2    Kowalsman, N.3    Ben-Yaakov, K.4    Shaked, M.5    Seger, R.6    Eisenstein, M.7    Fainzilber, M.8
  • 12
    • 0842290742 scopus 로고    scopus 로고
    • What is the importance of multivesicular bodies in retrograde axonal transport in vivo?
    • Weible II M.W., and Hendry I.A. What is the importance of multivesicular bodies in retrograde axonal transport in vivo?. J Neurobiol 58 (2004) 230-243
    • (2004) J Neurobiol , vol.58 , pp. 230-243
    • Weible II, M.W.1    Hendry, I.A.2
  • 15
    • 2342493315 scopus 로고    scopus 로고
    • Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice
    • Cafferty W.B., Gardiner N.J., Das P., Qiu J., McMahon S.B., and Thompson S.W. Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice. J Neurosci 24 (2004) 4432-4443
    • (2004) J Neurosci , vol.24 , pp. 4432-4443
    • Cafferty, W.B.1    Gardiner, N.J.2    Das, P.3    Qiu, J.4    McMahon, S.B.5    Thompson, S.W.6
  • 16
    • 33744997909 scopus 로고    scopus 로고
    • The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth
    • This study shows that the cytokine interleukin-6 is expressed in DRGs following peripheral conditioning injury and that IL-6 is sufficient to mimic the conditioning effect on DRG neurite outgrowth. Contrary to the findings of Cafferty et al. [15], the authors of this study show that IL-6 is not necessary for the enhancement of nerve growth state by a peripheral conditioning injury.
    • Cao Z., Gao Y., Bryson J.B., Hou J., Chaudhry N., Siddiq M., Martinez J., Spencer T., Carmel J., Hart R.B., et al. The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth. J Neurosci 26 (2006) 5565-5573. This study shows that the cytokine interleukin-6 is expressed in DRGs following peripheral conditioning injury and that IL-6 is sufficient to mimic the conditioning effect on DRG neurite outgrowth. Contrary to the findings of Cafferty et al. [15], the authors of this study show that IL-6 is not necessary for the enhancement of nerve growth state by a peripheral conditioning injury.
    • (2006) J Neurosci , vol.26 , pp. 5565-5573
    • Cao, Z.1    Gao, Y.2    Bryson, J.B.3    Hou, J.4    Chaudhry, N.5    Siddiq, M.6    Martinez, J.7    Spencer, T.8    Carmel, J.9    Hart, R.B.10
  • 17
    • 0029029582 scopus 로고
    • Induction of interleukin-6 in axotomized sensory neurons
    • Murphy P.G., Grondin J., Altares M., and Richardson P.M. Induction of interleukin-6 in axotomized sensory neurons. J Neurosci 15 (1995) 5130-5138
    • (1995) J Neurosci , vol.15 , pp. 5130-5138
    • Murphy, P.G.1    Grondin, J.2    Altares, M.3    Richardson, P.M.4
  • 18
    • 33847422165 scopus 로고    scopus 로고
    • Actions of neuropoietic cytokines and cyclic AMP in regenerative conditioning of rat primary sensory neurons
    • This report links the beneficial effects of cAMP activity on axonal regeneration to cytokine signaling. The authors show that addition of cAMP into DRGs induces the expression of neuropoietic cytokines IL-6 and LIF, which has been shown to be positive regulators of nerve regeneration.
    • Wu D., Zhang Y., Bo X., Huang W., Xiao F., Zhang X., Miao T., Magoulas C., Subang M.C., and Richardson P.M. Actions of neuropoietic cytokines and cyclic AMP in regenerative conditioning of rat primary sensory neurons. Exp Neurol 204 (2007) 66-76. This report links the beneficial effects of cAMP activity on axonal regeneration to cytokine signaling. The authors show that addition of cAMP into DRGs induces the expression of neuropoietic cytokines IL-6 and LIF, which has been shown to be positive regulators of nerve regeneration.
    • (2007) Exp Neurol , vol.204 , pp. 66-76
    • Wu, D.1    Zhang, Y.2    Bo, X.3    Huang, W.4    Xiao, F.5    Zhang, X.6    Miao, T.7    Magoulas, C.8    Subang, M.C.9    Richardson, P.M.10
  • 20
    • 0033664605 scopus 로고    scopus 로고
    • Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transection in the rat
    • Sheu J.Y., Kulhanek D.J., and Eckenstein F.P. Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transection in the rat. Exp Neurol 166 (2000) 392-402
    • (2000) Exp Neurol , vol.166 , pp. 392-402
    • Sheu, J.Y.1    Kulhanek, D.J.2    Eckenstein, F.P.3
  • 21
    • 2642535306 scopus 로고    scopus 로고
    • STAT3 phosphorylation in injured axons before sensory and motor neuron nuclei: potential role for STAT3 as a retrograde signaling transcription factor
    • Lee N., Neitzel K.L., Devlin B.K., and MacLennan A.J. STAT3 phosphorylation in injured axons before sensory and motor neuron nuclei: potential role for STAT3 as a retrograde signaling transcription factor. J Comp Neurol 474 (2004) 535-545
    • (2004) J Comp Neurol , vol.474 , pp. 535-545
    • Lee, N.1    Neitzel, K.L.2    Devlin, B.K.3    MacLennan, A.J.4
  • 22
    • 34548654054 scopus 로고    scopus 로고
    • Retrograde activation of STAT3 by leukemia inhibitory factor in sympathetic neurons
    • The authors of this study use compartmentalized cultures of sympathetic neurons to investigate the mechanism of LIF-mediated retrograde signaling. Their results support a signaling endosome model in which the LIF/gp130/Jak complex is internalized at the distal axon and retrogradely transported to mediate STAT3 activation in the cell body.
    • O'Brien J.J., and Nathanson N.M. Retrograde activation of STAT3 by leukemia inhibitory factor in sympathetic neurons. J Neurochem 103 (2007) 288-302. The authors of this study use compartmentalized cultures of sympathetic neurons to investigate the mechanism of LIF-mediated retrograde signaling. Their results support a signaling endosome model in which the LIF/gp130/Jak complex is internalized at the distal axon and retrogradely transported to mediate STAT3 activation in the cell body.
    • (2007) J Neurochem , vol.103 , pp. 288-302
    • O'Brien, J.J.1    Nathanson, N.M.2
  • 23
    • 0012387688 scopus 로고    scopus 로고
    • Peripheral but not central axotomy induces changes in Janus kinases (JAK) and signal transducers and activators of transcription (STAT)
    • Schwaiger F.W., Hager G., Schmitt A.B., Horvat A., Hager G., Streif R., Spitzer C., Gamal S., Breuer S., Brook G.A., et al. Peripheral but not central axotomy induces changes in Janus kinases (JAK) and signal transducers and activators of transcription (STAT). Eur J Neurosci 12 (2000) 1165-1176
    • (2000) Eur J Neurosci , vol.12 , pp. 1165-1176
    • Schwaiger, F.W.1    Hager, G.2    Schmitt, A.B.3    Horvat, A.4    Hager, G.5    Streif, R.6    Spitzer, C.7    Gamal, S.8    Breuer, S.9    Brook, G.A.10
  • 24
    • 14044250276 scopus 로고    scopus 로고
    • Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation
    • This study finds that peripheral, but not central axotomy induces STAT3 activation in DRG neurons. By pharmacological inhibition of STAT3 activation in sciatic nerve in vivo, the authors show that STAT3 activation is required for peripheral nerve regeneration.
    • Qiu J., Cafferty W.B., McMahon S.B., and Thompson S.W. Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation. J Neurosci 25 (2005) 1645-1653. This study finds that peripheral, but not central axotomy induces STAT3 activation in DRG neurons. By pharmacological inhibition of STAT3 activation in sciatic nerve in vivo, the authors show that STAT3 activation is required for peripheral nerve regeneration.
    • (2005) J Neurosci , vol.25 , pp. 1645-1653
    • Qiu, J.1    Cafferty, W.B.2    McMahon, S.B.3    Thompson, S.W.4
  • 25
    • 33748681723 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 suppresses the ability of activated signal transducer and activator of transcription-3 to stimulate neurite growth in rat primary sensory neurons
    • This study identifies SOC3 as an inhibitor of STAT3 activation, and a negative regulator of neurite outgrowth in vitro. This observation raises the possibility that SOC3 may contribute to the inability of CNS neurons to regenerate following injury.
    • Miao T., Wu D., Zhang Y., Bo X., Subang M.C., Wang P., and Richardson P.M. Suppressor of cytokine signaling-3 suppresses the ability of activated signal transducer and activator of transcription-3 to stimulate neurite growth in rat primary sensory neurons. J Neurosci 26 (2006) 9512-9519. This study identifies SOC3 as an inhibitor of STAT3 activation, and a negative regulator of neurite outgrowth in vitro. This observation raises the possibility that SOC3 may contribute to the inability of CNS neurons to regenerate following injury.
    • (2006) J Neurosci , vol.26 , pp. 9512-9519
    • Miao, T.1    Wu, D.2    Zhang, Y.3    Bo, X.4    Subang, M.C.5    Wang, P.6    Richardson, P.M.7
  • 26
    • 19044374577 scopus 로고    scopus 로고
    • Early changes in gene expression in the dorsal root ganglia after transection of the sciatic nerve; effects of amphiregulin and PAI-1 on regeneration
    • Nilsson A., Moller K., Dahlin L., Lundborg G., and Kanje M. Early changes in gene expression in the dorsal root ganglia after transection of the sciatic nerve; effects of amphiregulin and PAI-1 on regeneration. Brain Res Mol Brain Res 136 (2005) 65-74
    • (2005) Brain Res Mol Brain Res , vol.136 , pp. 65-74
    • Nilsson, A.1    Moller, K.2    Dahlin, L.3    Lundborg, G.4    Kanje, M.5
  • 27
    • 33646541355 scopus 로고    scopus 로고
    • New insights into neuronal regeneration: the role of axonal protein synthesis in pathfinding and axonal extension
    • Twiss J.L., and van Minnen J. New insights into neuronal regeneration: the role of axonal protein synthesis in pathfinding and axonal extension. J Neurotrauma 23 (2006) 295-308
    • (2006) J Neurotrauma , vol.23 , pp. 295-308
    • Twiss, J.L.1    van Minnen, J.2
  • 30
    • 10044238913 scopus 로고    scopus 로고
    • Acute physiological response of mammalian central neurons to axotomy: ionic regulation and electrical activity
    • Mandolesi G., Madeddu F., Bozzi Y., Maffei L., and Ratto G.M. Acute physiological response of mammalian central neurons to axotomy: ionic regulation and electrical activity. FASEB J 18 (2004) 1934-1936
    • (2004) FASEB J , vol.18 , pp. 1934-1936
    • Mandolesi, G.1    Madeddu, F.2    Bozzi, Y.3    Maffei, L.4    Ratto, G.M.5
  • 31
    • 18844378875 scopus 로고    scopus 로고
    • The ability of axons to regenerate their growth cones depends on axonal type and age, and is regulated by calcium, cAMP and ERK
    • Chierzi S., Ratto G.M., Verma P., and Fawcett J.W. The ability of axons to regenerate their growth cones depends on axonal type and age, and is regulated by calcium, cAMP and ERK. Eur J Neurosci 21 (2005) 2051-2062
    • (2005) Eur J Neurosci , vol.21 , pp. 2051-2062
    • Chierzi, S.1    Ratto, G.M.2    Verma, P.3    Fawcett, J.W.4
  • 32
    • 3342900171 scopus 로고    scopus 로고
    • Electrical stimulation accelerates and enhances expression of regeneration-associated genes in regenerating rat femoral motoneurons
    • Al-Majed A.A., Tam S.L., and Gordon T. Electrical stimulation accelerates and enhances expression of regeneration-associated genes in regenerating rat femoral motoneurons. Cell Mol Neurobiol 24 (2004) 379-402
    • (2004) Cell Mol Neurobiol , vol.24 , pp. 379-402
    • Al-Majed, A.A.1    Tam, S.L.2    Gordon, T.3
  • 33
    • 39249085066 scopus 로고    scopus 로고
    • Electrical stimulation of intact peripheral sensory axons in rats promotes outgrowth of their central projections
    • The authors demonstrate that electrical stimulation in the intact sciatic nerve mimics the conditioning-injury effect on DRG axon outgrowth, and that this effect of electrical stimulation is correlated with increased cAMP activity.
    • Udina E., Furey M., Busch S., Silver J., Gordon T., and Fouad K. Electrical stimulation of intact peripheral sensory axons in rats promotes outgrowth of their central projections. Exp Neurol 210 (2008) 238-247. The authors demonstrate that electrical stimulation in the intact sciatic nerve mimics the conditioning-injury effect on DRG axon outgrowth, and that this effect of electrical stimulation is correlated with increased cAMP activity.
    • (2008) Exp Neurol , vol.210 , pp. 238-247
    • Udina, E.1    Furey, M.2    Busch, S.3    Silver, J.4    Gordon, T.5    Fouad, K.6
  • 34
    • 29344454055 scopus 로고    scopus 로고
    • An investigation into the potential for activity-dependent regeneration of the rubrospinal tract after spinal cord injury
    • Harvey P.J., Grochmal J., Tetzlaff W., Gordon T., and Bennett D.J. An investigation into the potential for activity-dependent regeneration of the rubrospinal tract after spinal cord injury. Eur J Neurosci 22 (2005) 3025-3035
    • (2005) Eur J Neurosci , vol.22 , pp. 3025-3035
    • Harvey, P.J.1    Grochmal, J.2    Tetzlaff, W.3    Gordon, T.4    Bennett, D.J.5
  • 36
    • 33745712928 scopus 로고    scopus 로고
    • Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells
    • This study identified oncomodulin as a macrophaged-derived secreted factor that promotes the regeneration of injured retinal ganglion cells. The study further shows that oncomodulin can stimulate neurite outgrowth in cultured DRG neurons.
    • Yin Y., Henzl M.T., Lorber B., Nakazawa T., Thomas T.T., Jiang F., Langer R., and Benowitz L.I. Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nat Neurosci 9 (2006) 843-852. This study identified oncomodulin as a macrophaged-derived secreted factor that promotes the regeneration of injured retinal ganglion cells. The study further shows that oncomodulin can stimulate neurite outgrowth in cultured DRG neurons.
    • (2006) Nat Neurosci , vol.9 , pp. 843-852
    • Yin, Y.1    Henzl, M.T.2    Lorber, B.3    Nakazawa, T.4    Thomas, T.T.5    Jiang, F.6    Langer, R.7    Benowitz, L.I.8
  • 37
    • 36749004288 scopus 로고    scopus 로고
    • Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation
    • Muller A., Hauk T.G., and Fischer D. Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation. Brain 130 (2007) 3308-3320
    • (2007) Brain , vol.130 , pp. 3308-3320
    • Muller, A.1    Hauk, T.G.2    Fischer, D.3
  • 38
    • 10044292873 scopus 로고    scopus 로고
    • Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells
    • Park K., Luo J.M., Hisheh S., Harvey A.R., and Cui Q. Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells. J Neurosci 24 (2004) 10806-10815
    • (2004) J Neurosci , vol.24 , pp. 10806-10815
    • Park, K.1    Luo, J.M.2    Hisheh, S.3    Harvey, A.R.4    Cui, Q.5
  • 39
    • 38649128184 scopus 로고    scopus 로고
    • The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury
    • Hannila S.S., and Filbin M.T. The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury. Exp Neurol 209 (2008) 321-332
    • (2008) Exp Neurol , vol.209 , pp. 321-332
    • Hannila, S.S.1    Filbin, M.T.2
  • 41
    • 0031029782 scopus 로고    scopus 로고
    • A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth
    • Smith D.S., and Skene J.H. A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth. J Neurosci 17 (1997) 646-658
    • (1997) J Neurosci , vol.17 , pp. 646-658
    • Smith, D.S.1    Skene, J.H.2
  • 43
    • 38849124121 scopus 로고    scopus 로고
    • Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival
    • The authors of this study show that axonal protein synthesis is required for NGF-dependent cell survival in developing sensory neurons. They further show that the transcription factor CREB is locally translated by NGF signaling and that newly synthesized CREB is retrogradely transported to the cell body.
    • Cox L.J., Hengst U., Gurskaya N.G., Lukyanov K.A., and Jaffrey S.R. Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival. Nat Cell Biol 10 (2008) 149-159. The authors of this study show that axonal protein synthesis is required for NGF-dependent cell survival in developing sensory neurons. They further show that the transcription factor CREB is locally translated by NGF signaling and that newly synthesized CREB is retrogradely transported to the cell body.
    • (2008) Nat Cell Biol , vol.10 , pp. 149-159
    • Cox, L.J.1    Hengst, U.2    Gurskaya, N.G.3    Lukyanov, K.A.4    Jaffrey, S.R.5
  • 44
    • 0037104645 scopus 로고    scopus 로고
    • Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro
    • Cai D., Deng K., Mellado W., Lee J., Ratan R.R., and Filbin M.T. Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro. Neuron 35 (2002) 711-719
    • (2002) Neuron , vol.35 , pp. 711-719
    • Cai, D.1    Deng, K.2    Mellado, W.3    Lee, J.4    Ratan, R.R.5    Filbin, M.T.6
  • 46
    • 0037036144 scopus 로고    scopus 로고
    • Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells
    • Goldberg J.L., Klassen M.P., Hua Y., and Barres B.A. Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells. Science 296 (2002) 1860-1864
    • (2002) Science , vol.296 , pp. 1860-1864
    • Goldberg, J.L.1    Klassen, M.P.2    Hua, Y.3    Barres, B.A.4
  • 47
    • 0025935250 scopus 로고
    • Selective expression of Jun proteins following axotomy and axonal transport block in peripheral nerves in the rat: evidence for a role in the regeneration process
    • Leah J.D., Herdegen T., and Bravo R. Selective expression of Jun proteins following axotomy and axonal transport block in peripheral nerves in the rat: evidence for a role in the regeneration process. Brain Res 566 (1991) 198-207
    • (1991) Brain Res , vol.566 , pp. 198-207
    • Leah, J.D.1    Herdegen, T.2    Bravo, R.3
  • 48
    • 0025826445 scopus 로고
    • Long-term increase in the levels of c-jun mRNA and jun protein-like immunoreactivity in motor and sensory neurons following axon damage
    • Jenkins R., and Hunt S.P. Long-term increase in the levels of c-jun mRNA and jun protein-like immunoreactivity in motor and sensory neurons following axon damage. Neurosci Lett 129 (1991) 107-110
    • (1991) Neurosci Lett , vol.129 , pp. 107-110
    • Jenkins, R.1    Hunt, S.P.2
  • 49
    • 0142151019 scopus 로고    scopus 로고
    • Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth
    • Tanabe K., Bonilla I., Winkles J.A., and Strittmatter S.M. Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth. J Neurosci 23 (2003) 9675-9686
    • (2003) J Neurosci , vol.23 , pp. 9675-9686
    • Tanabe, K.1    Bonilla, I.2    Winkles, J.A.3    Strittmatter, S.M.4
  • 50
    • 0033956898 scopus 로고    scopus 로고
    • Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: a novel neuronal marker of nerve injury
    • Tsujino H., Kondo E., Fukuoka T., Dai Y., Tokunaga A., Miki K., Yonenobu K., Ochi T., and Noguchi K. Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: a novel neuronal marker of nerve injury. Mol Cell Neurosci 15 (2000) 170-182
    • (2000) Mol Cell Neurosci , vol.15 , pp. 170-182
    • Tsujino, H.1    Kondo, E.2    Fukuoka, T.3    Dai, Y.4    Tokunaga, A.5    Miki, K.6    Yonenobu, K.7    Ochi, T.8    Noguchi, K.9
  • 52
    • 0031264489 scopus 로고    scopus 로고
    • Bregman BS. c-Jun expression in adult rat dorsal root ganglion neurons: differential response after central or peripheral axotomy
    • Broude E., McAtee M., and Kelley M.S. Bregman BS. c-Jun expression in adult rat dorsal root ganglion neurons: differential response after central or peripheral axotomy. Exp Neurol 148 (1997) 367-377
    • (1997) Exp Neurol , vol.148 , pp. 367-377
    • Broude, E.1    McAtee, M.2    Kelley, M.S.3
  • 53
    • 0032519651 scopus 로고    scopus 로고
    • Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat dorsal root ganglia in vivo
    • Kenney A.M., and Kocsis J.D. Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat dorsal root ganglia in vivo. J Neurosci 18 (1998) 1318-1328
    • (1998) J Neurosci , vol.18 , pp. 1318-1328
    • Kenney, A.M.1    Kocsis, J.D.2
  • 54
    • 0032527879 scopus 로고    scopus 로고
    • Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury
    • Herdegen T., Claret F.X., Kallunki T., Martin-Villalba A., Winter C., Hunter T., and Karin M. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J Neurosci 18 (1998) 5124-5135
    • (1998) J Neurosci , vol.18 , pp. 5124-5135
    • Herdegen, T.1    Claret, F.X.2    Kallunki, T.3    Martin-Villalba, A.4    Winter, C.5    Hunter, T.6    Karin, M.7
  • 55
    • 33745001188 scopus 로고    scopus 로고
    • The transcription factor ATF-3 promotes neurite outgrowth
    • Seijffers R., Allchorne A.J., and Woolf C.J. The transcription factor ATF-3 promotes neurite outgrowth. Mol Cell Neurosci 32 (2006) 143-154
    • (2006) Mol Cell Neurosci , vol.32 , pp. 143-154
    • Seijffers, R.1    Allchorne, A.J.2    Woolf, C.J.3
  • 56
    • 34547484768 scopus 로고    scopus 로고
    • ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration
    • Using transgenic mice that constitutively express ATF-3 in neurons, the authors of this study show that ATF-3 increases axonal growth capacity following a sciatic nerve conditioning injury.
    • Seijffers R., Mills C.D., and Woolf C.J. ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration. J Neurosci 27 (2007) 7911-7920. Using transgenic mice that constitutively express ATF-3 in neurons, the authors of this study show that ATF-3 increases axonal growth capacity following a sciatic nerve conditioning injury.
    • (2007) J Neurosci , vol.27 , pp. 7911-7920
    • Seijffers, R.1    Mills, C.D.2    Woolf, C.J.3
  • 57
    • 0037148523 scopus 로고    scopus 로고
    • Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult
    • Schweizer U., Gunnersen J., Karch C., Wiese S., Holtmann B., Takeda K., Akira S., and Sendtner M. Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult. J Cell Biol 156 (2002) 287-297
    • (2002) J Cell Biol , vol.156 , pp. 287-297
    • Schweizer, U.1    Gunnersen, J.2    Karch, C.3    Wiese, S.4    Holtmann, B.5    Takeda, K.6    Akira, S.7    Sendtner, M.8
  • 58
    • 33750921806 scopus 로고    scopus 로고
    • SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growth
    • This study provides extensive in vitro evidence for the role of Sox11 in the regulation of neuronal survival and neurite outgrowth in sensory neurons. DNA microarray analysis from neuroblastoma cells shows that Sox11 regulates the expression of apoptosis-related genes.
    • Jankowski M.P., Cornuet P.K., McIlwrath S., Koerber H.R., and Albers K.M. SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growth. Neuroscience 143 (2006) 501-514. This study provides extensive in vitro evidence for the role of Sox11 in the regulation of neuronal survival and neurite outgrowth in sensory neurons. DNA microarray analysis from neuroblastoma cells shows that Sox11 regulates the expression of apoptosis-related genes.
    • (2006) Neuroscience , vol.143 , pp. 501-514
    • Jankowski, M.P.1    Cornuet, P.K.2    McIlwrath, S.3    Koerber, H.R.4    Albers, K.M.5
  • 59
    • 33646857906 scopus 로고    scopus 로고
    • Actions of neurotrophic factors and their signaling pathways in neuronal survival and axonal regeneration
    • Cui Q. Actions of neurotrophic factors and their signaling pathways in neuronal survival and axonal regeneration. Mol Neurobiol 33 (2006) 155-179
    • (2006) Mol Neurobiol , vol.33 , pp. 155-179
    • Cui, Q.1
  • 60
    • 0034608339 scopus 로고    scopus 로고
    • Expression of glial cell line-derived neurotrophic factor family of growth factors in peripheral nerve injury in rats
    • Hoke A., Cheng C., and Zochodne D.W. Expression of glial cell line-derived neurotrophic factor family of growth factors in peripheral nerve injury in rats. Neuroreport 11 (2000) 1651-1654
    • (2000) Neuroreport , vol.11 , pp. 1651-1654
    • Hoke, A.1    Cheng, C.2    Zochodne, D.W.3
  • 61
    • 34548684100 scopus 로고    scopus 로고
    • GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord
    • This study explores the role of GDNF in peripheral nerve regeneration. The authors show that peripheral nerve injury upregulates components of GDNF signaling, and that exogenous GDNF treatment enhances the effect of conditioning-injury on neurite outgrowth.
    • Mills C.D., Allchorne A.J., Griffin R.S., Woolf C.J., and Costigan M. GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord. Mol Cell Neurosci 36 (2007) 185-194. This study explores the role of GDNF in peripheral nerve regeneration. The authors show that peripheral nerve injury upregulates components of GDNF signaling, and that exogenous GDNF treatment enhances the effect of conditioning-injury on neurite outgrowth.
    • (2007) Mol Cell Neurosci , vol.36 , pp. 185-194
    • Mills, C.D.1    Allchorne, A.J.2    Griffin, R.S.3    Woolf, C.J.4    Costigan, M.5
  • 62
    • 5644261276 scopus 로고    scopus 로고
    • Retrograde propagation of GDNF-mediated signals in sympathetic neurons
    • Coulpier M., and Ibanez C.F. Retrograde propagation of GDNF-mediated signals in sympathetic neurons. Mol Cell Neurosci 27 (2004) 132-139
    • (2004) Mol Cell Neurosci , vol.27 , pp. 132-139
    • Coulpier, M.1    Ibanez, C.F.2
  • 63
    • 0034785028 scopus 로고    scopus 로고
    • The role of basic fibroblast growth factor in peripheral nerve regeneration
    • Grothe C., and Nikkhah G. The role of basic fibroblast growth factor in peripheral nerve regeneration. Anat Embryol (Berl) 204 (2001) 171-177
    • (2001) Anat Embryol (Berl) , vol.204 , pp. 171-177
    • Grothe, C.1    Nikkhah, G.2
  • 64
    • 33747124061 scopus 로고    scopus 로고
    • Faster nerve regeneration after sciatic nerve injury in mice over-expressing basic fibroblast growth factor
    • This carefully conducted study uses transgenic mice overexpressing FGF-2 to address the contribution of FGF-2 to nerve regeneration. The authors find that FGF-2 overexpression facilitates peripheral nerve regeneration following crush injury by regulating axonal growth, Schwann cell proliferation and axonal myelination.
    • Jungnickel J., Haase K., Konitzer J., Timmer M., and Grothe C. Faster nerve regeneration after sciatic nerve injury in mice over-expressing basic fibroblast growth factor. J Neurobiol 66 (2006) 940-948. This carefully conducted study uses transgenic mice overexpressing FGF-2 to address the contribution of FGF-2 to nerve regeneration. The authors find that FGF-2 overexpression facilitates peripheral nerve regeneration following crush injury by regulating axonal growth, Schwann cell proliferation and axonal myelination.
    • (2006) J Neurobiol , vol.66 , pp. 940-948
    • Jungnickel, J.1    Haase, K.2    Konitzer, J.3    Timmer, M.4    Grothe, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.