Heterogeneity of reactive astrocytes

Neuroscience Letters

Volumn 565, Issue , 2014, Pages 23-29

  Anderson, Mark A ^a   Ao, Yan ^a   Sofroniew, Michael V ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autoimmune disease; Glial scar; Heterogeneity; Inflammation; Reactive astrogliosis; Trauma

Indexed keywords

ACID PROTEIN; G PROTEIN COUPLED RECEPTOR; GLIAL FIBRILLARY ACID PROTEIN; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ASTROCYTE; ASTROCYTOSIS; BRAIN REGION; CELL DIFFERENTIATION; CELL FUNCTION; CELL HETEROGENEITY; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; GENE EXPRESSION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MACROGLIA; NONHUMAN; PRIORITY JOURNAL; REVIEW; SCAR FORMATION; UPREGULATION;

AUTOIMMUNE DISEASE; GLIAL SCAR; HETEROGENEITY; INFLAMMATION; REACTIVE ASTROGLIOSIS; TRAUMA;

ANIMALS; ASTROCYTES; BRAIN; CELL PROLIFERATION; CELL SIZE; CICATRIX; GENE EXPRESSION; GLIOSIS; HUMANS; SIGNAL TRANSDUCTION; SPINAL CORD; TERMINOLOGY AS TOPIC;

EID: 84897077420     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.12.030     Document Type: Review

References (56)

1. Aldrich A., Kielian T. Central nervous system fibrosis is associated with fibrocyte-like infiltrates. Am. J. Pathol. 2011, 179:2952-2962.
2. Allaman I., Belanger M., Magistretti P.J. Astrocyte-neuron metabolic relationships: for better and for worse. Trends Neurosci. 2011, 34:76-87.
3. Attwell D., Buchan A.M., Charpak S., Lauritzen M., Macvicar B.A., Newman E.A. Glial and neuronal control of brain blood flow. Nature 2010, 468:232-243.
4. Bachoo R.M., Kim R.S., Ligon K.L., Maher E.A., Brennan C., Billings N., Chan S., Li C., Rowitch D.H., Wong W.H., DePinho R.A. Molecular diversity of astrocytes with implications for neurological disorders. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:8384-8389.
5. Bardehle S., Kruger M., Buggenthin F., Schwausch J., Ninkovic J., Clevers H., Snippert H.J., Theis F.J., Meyer-Luehmann M., Bechmann I., Dimou L., Gotz M. Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nat. Neurosci. 2013, 16:580-586.
6. Benner E.J., Luciano D., Jo R., Abdi K., Paez-Gonzalez P., Sheng H., Warner D.S., Liu C., Eroglu C., Kuo C.T. Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature 2013, 497:369-373.
7. Brambilla R., Bracchi-Ricard V., Hu W.H., Frydel B., Bramwell A., Karmally S., Green E.J., Bethea J.R. Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. J. Exp. Med. 2005, 202:145-156.
8. Brambilla R., Persaud T., Hu X., Karmally S., Shestopalov V.I., Dvoriantchikova G., Ivanov D., Nathanson L., Barnum S.R., Bethea J.R. Transgenic inhibition of astroglial NF-kappaB improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation. J. Immunol. 2009, 182:2628-2640.
9. Bundesen L.Q., Scheel T.A., Bregman B.S., Kromer L.F. Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats. J. Neurosci. 2003, 23:7789-7800.
10. Bush T.G., Puvanachandra N., Horner C.H., Polito A., Ostenfeld T., Svendsen C.N., Mucke L., Johnson M.H., Sofroniew M.V. Leukocyte infiltration, neuronal degeneration and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron 1999, 23:297-308.
11. Bushong E.A., Martone M.A., Jones Y.Z., Ellisman M.H. Protoplasmic astrocytes in CA1 atratum radiatum occupy separate anatomical domains. J. Neurosci. 2002, 22:183-192.
12. Cahoy J.D., Emery B., Kaushal A., Foo L.C., Zamanian J.L., Christopherson K.S., Xing Y., Lubischer J.L., Krieg P.A., Krupenko S.A., Thompson W.J., Barres B.A. A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J. Neurosci. 2008, 28:264-278.
13. Clarke L.E., Barres B.A. Emerging roles of astrocytes in neural circuit development. Nat. Rev. Neurosci. 2013, 14:311-321.
14. Drogemuller K., Helmuth U., Brunn A., Sakowicz-Burkiewicz M., Gutmann D.H., Mueller W., Deckert M., Schluter D. Astrocyte gp130 expression is critical for the control of toxoplasma encephalitis. J. Immunol. 2008, 181:2683-2693.
15. Eddleston M., Mucke L. Molecular profile of reactive astrocytes - implications for their role in neurological disease. Neuroscience 1993, 54:15-36.
16. Failli V., Kopp M.A., Gericke C., Martus P., Klingbeil S., Brommer B., Laginha I., Chen Y., DeVivo M.J., Dirnagl U., Schwab J.M. Functional neurological recovery after spinal cord injury is impaired in patients with infections. Brain 2012, 135:3238-3250.
17. Faulkner J.R., Herrmann J.E., Woo M.J., Tansey K.E., Doan N.B., Sofroniew M.V. Reactive astrocytes protect tissue and preserve function after spinal cord injury. J. Neurosci. 2004, 24:2143-2155.
18. Gadea A., Schinelli S., Gallo V. Endothelin-1 regulates astrocyte proliferation and reactive gliosis via a JNK/c-Jun signaling pathway. J. Neurosci. 2008, 28:2394-2408.
19. Garcia A.D., Petrova R., Eng L., Joyner A.L. Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain. J. Neurosci. 2010, 30:13597-13608.
20. Halassa M.M., Haydon P.G. Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annu. Rev. Physiol. 2010, 72:335-355.
21. Hamby M.E., Coppola G., Ao Y., Geschwind D.H., Khakh B.S., Sofroniew M.V. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple g-protein-coupled receptors. J. Neurosci. 2012, 32:14489-14510.
22. Haroon F., Drogemuller K., Handel U., Brunn A., Reinhold D., Nishanth G., Mueller W., Trautwein C., Ernst M., Deckert M., Schluter D. Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation. J. Immunol. 2011, 186:6521-6531.
23. Hatten M.E., Liem R.K., Shelanski M.L., Mason C.A. Astroglia in CNS injury. Glia 1991, 4:233-243.
24. Herrmann J.E., Imura T., Song B., Qi J., Ao Y., Nguyen T.K., Korsak R.A., Takeda K., Akira S., Sofroniew M.V. STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J. Neurosci. 2008, 28:7231-7243.
25. Iadecola C., Nedergaard M. Glial regulation of the cerebral microvasculature. Nat. Neurosci. 2007, 10:1369-1376.
26. Imura T., Nakano I., Kornblum H.I., Sofroniew M.V. Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes. Glia 2006, 53:277-293.
27. John G.R., Lee S.C., Song X., Rivieccio M., Brosnan C.F. IL-1-regulated responses in astrocytes: relevance to injury and recovery. Glia 2005, 49:161-176.
28. Lee S., Park J.Y., Lee W.H., Kim H., Park H.C., Mori K., Suk K. Lipocalin-2 is an autocrine mediator of reactive astrocytosis. J. Neurosci. 2009, 29:234-249.
29. Levison S.W., Jiang F.J., Stoltzfus O.K., Ducceschi M.H. IL-6-type cytokines enhance epidermal growth factor-stimulated astrocyte proliferation. Glia 2000, 32:328-337.
30. Lichter-Konecki U., Mangin J.M., Gordish-Dressman H., Hoffman E.P., Gallo V. Gene expression profiling of astrocytes from hyperammonemic mice reveals altered pathways for water and potassium homeostasis in vivo. Glia 2008, 56:365-377.
31. Meeuwsen S., Persoon-Deen C., Bsibsi M., Ravid R., van Noort J.M. Cytokine, chemokine and growth factor gene profiling of cultured human astrocytes after exposure to proinflammatory stimuli. Glia 2003, 43:243-253.
32. Neary J.T., Zimmermann H. Trophic functions of nucleotides in the central nervous system. Trends Neurosci. 2009, 32:189-198.
33. Norton W.T., Aquino D.A., Hozumi I., Chiu F.C., Brosnan C.F. Quantitative aspects of reactive gliosis: a review. Neurochem. Res. 1992, 17:877-885.
34. Obara M., Szeliga M., Albrecht J. Regulation of pH in the mammalian central nervous system under normal and pathological conditions: facts and hypotheses. Neurochem. Int. 2008, 52:905-919.
35. Okada S., Nakamura M., Katoh H., Miyao T., Shimazaki T., Ishii K., Yamane J., Yoshimura A., Iwamoto Y., Toyama Y., Okano H. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat. Med. 2006, 12:829-834.
36. Orre M., Kamphuis W., Osborn L.M., Melief J., Kooijman L., Huitinga I., Klooster J., Bossers K., Hol E.M. Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice. Neurobiol. Aging 2014, 35:1-14.
37. Pang Y., Cai Z., Rhodes P.G. Analysis of genes differentially expressed in astrocytes stimulated with lipopolysaccharide using cDNA arrays. Brain Res. 2001, 914:15-22.
38. Papadopoulos M.C., Verkman A.S. Aquaporin water channels in the nervous system. Nat. Rev. Neurosci. 2013.
39. Rash J.E. Molecular disruptions of the panglial syncytium block potassium siphoning and axonal saltatory conduction: pertinence to neuromyelitis optica and other demyelinating diseases of the central nervous system. Neuroscience 2010, 168:982-1008.
40. Reilkoff R.A., Bucala R., Herzog E.L. Fibrocytes: emerging effector cells in chronic inflammation. Nat. Rev. Immunol. 2011, 11:427-435.
41. Sattler R., Rothstein J.D. Regulation and dysregulation of glutamate transporters. Handb. Exp. Pharmacol. 2006, 27(3):7-30.
42. Schousboe A., Sarup A., Bak L.K., Waagepetersen H.S., Larsson O.M. Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission. Neurochem. Int. 2004, 45:521-527.
43. Silver J., Miller J.H. Regeneration beyond the glial scar. Nat. Rev. Neurosci. 2004, 5:146-156.
44. Simard M., Nedergaard M. The neurobiology of glia in the context of water and ion homeostasis. Neuroscience 2004, 129:877-896.
45. Sofroniew M.V. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 2009, 32:638-647.
46. Sofroniew M.V. Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators. Neuroscientist 2013, 10.1177/1073858413504466.
47. Sofroniew M.V., Vinters H.V. Astrocytes: biology and pathology. Acta Neuropathol. 2010, 119:7-35.
48. Takano T., Tian G.F., Peng W., Lou N., Libionka W., Han X., Nedergaard M. Astrocyte-mediated control of cerebral blood flow. Nat. Neurosci. 2006, 9:260-267.
49. Tong X., Shigetomi E., Looger L.L., Khakh B.S. Genetically encoded calcium indicators and astrocyte calcium microdomains. Neuroscientist 2013, 19:274-291.
50. Tsai H.H., Li H., Fuentealba L.C., Molofsky A.V., Taveira-Marques R., Zhuang H., Tenney A., Murnen A.T., Fancy S.P., Merkle F., Kessaris N., Alvarez-Buylla A., Richardson W.D., Rowitch D.H. Regional astrocyte allocation regulates CNS synaptogenesis and repair. Science 2012, 337:358-362.
51. Verkhratsky A., Orkand R.K., Kettenmann H. Glial calcium: homeostasis and signaling function. Physiol. Rev. 1998, 78:99-141.
52. Voskuhl R.R., Peterson R.S., Song B., Ao Y., Morales L.B., Tiwari-Woodruff S., Sofroniew M.V. Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. J. Neurosci. 2009, 29:11511-11522.
53. Wanner I.B., Anderson M.A., Song B., Levine J., Fernandez A., Gray-Thompson Z., Ao Y., Sofroniew M.V. Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury. J. Neurosci. 2013, 33:12870-12886.
54. Wilhelmsson U., Bushong E.A., Price D.L., Smarr B.L., Phung V., Terada M., Ellisman M.H., Pekny M. Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:17513-17518.
55. Zamanian J.L., Xu L., Foo L.C., Nouri N., Zhou L., Giffard R.G., Barres B.A. Genomic analysis of reactive astrogliosis. J. Neurosci. 2012, 32:6391-6410.
56. Zhang Y., Barres B.A. Astrocyte heterogeneity: an underappreciated topic in neurobiology. Curr. Opin. Neurobiol. 2010, 20:588-594.