Defeating inhibition of regeneration by scar and myelin components

Handbook of Clinical Neurology

Volumn 109, Issue , 2012, Pages 503-522

  Fawcett, James W ^a   Schwab, Martin E ^b   Montani, Laura ^b   Brazda, Nicole ^c   Müller, Hans Werner ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b University of Zurich Brain Research Institute   (Switzerland)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84867760894     PISSN: 00729752     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-444-52137-8.00031-0     Document Type: Chapter

References (217)

1. Aguayo A.J., David S., Bray G.M. Influences of the glial environment on the elongation of axons after injury: transplantation studies in adult rodents. J Exp Biol 1981, 95:231-240.
2. Bandtlow C., Dechant G. From cell death to neuronal regeneration, effects of the p75 neurotrophin receptor depend on interactions with partner subunits. Sci STKE 2004, 2004:pe24.
3. Baptiste D.C., Fehlings M.G. Update on the treatment of spinal cord injury. Prog Brain Res 2007, 161:217-233.
4. Bareyre F.M., Haudenschild B., Schwab M.E. Long-lasting sprouting and gene expression changes induced by the monoclonal antibody IN-1 in the adult spinal cord. J Neurosci 2002, 22:7097-7110.
5. Bareyre F.M., Kerschensteiner M., Raineteau O., et al. The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat Neurosci 2004, 7:269-277.
6. Barker R.A., Dunnett S.B., Faissner A., et al. The time course of loss of dopaminergic neurons and the gliotic reaction surrounding grafts of embryonic mesencephalon to the striatum. Exp Neurol 1996, 141:79-93.
7. Barron K.D., Dentinger M.P., Popp A.J., et al. Neurons of layer Vb of rat sensorimotor cortex atrophy but do not die after thoracic cord transection. J Neuropathol Exp Neurol 1988, 47:62-74.
8. Bartsch U., Bandtlow C.E., Schnell L., et al. Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS. Neuron 1995, 15:1375-1381.
9. Benson M.D., Romero M.I., Lush M.E., et al. Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. Proc Natl Acad Sci U S A 2005, 102:10694-10699.
10. Berry M., Maxwell W.L., Logan A., et al. Deposition of scar tissue in the central nervous system. Acta Neurochir Suppl (Wien) 1983, 32:31-53.
11. Blochlinger S., Weinmann O., Schwab M.E., et al. Neuronal plasticity and formation of new synaptic contacts follow pyramidal lesions and neutralization of Nogo-A: a light and electron microscopic study in the pontine nuclei of adult rats. J Comp Neurol 2001, 433:426-436.
12. Bradbury E.J., Moon L.D.F., Popat R.J., et al. Chondroitinase ABC promotes axon regeneration and functional recovery following spinal cord injury. Nature 2002, 416:636-640.
13. Bregman B.S., Kunkel-Bagden E., Schnell L., et al. Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature 1995, 378:498-501.
14. Brittis P.A., Flanagan J.G. Nogo domains and a Nogo receptor: implications for axon regeneration. Neuron 2001, 30:11-14.
15. Brockes J.P., Kumar A. Comparative aspects of animal regeneration. Annu Rev Cell Dev Biol 2008, 24:525-549.
16. Brosamle C., Huber A.B., Fiedler M., et al. Regeneration of lesioned corticospinal tract fibers in the adult rat induced by a recombinant, humanized IN-1 antibody fragment. J Neurosci 2000, 20:8061-8068.
17. Buffo A., Zagrebelsky M., Huber A.B., et al. Application of neutralizing antibodies against NI-35/250 myelin-associated neurite growth inhibitory proteins to the adult rat cerebellum induces sprouting of uninjured purkinje cell axons. J Neurosci 2000, 20:2275-2286.
18. Bundesen L.Q., Scheel T.A., Bregman B.S., et al. Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats. J Neurosci 2003, 23:7789-7800.
19. Burjanadze T.V. New analysis of the phylogenetic change of collagen thermostability. Biopolymers 2000, 53:523-528.
20. Busch S.A., Silver J. The role of extracellular matrix in CNS regeneration. Curr Opin Neurobiol 2007, 17:120-127.
21. Camand E., Morel M.P., Faissner A., et al. Long-term changes in the molecular composition of the glial scar and progressive increase of serotoninergic fibre sprouting after hemisection of the mouse spinal cord. Eur J Neurosci 2004, 20:1161-1176.
22. Cao Y., Shumsky J.S., Sabol M.A., et al. Nogo-66 receptor antagonist peptide (NEP1-40) administration promotes functional recovery and axonal growth after lateral funiculus injury in the adult rat. Neurorehabil Neural Repair 2008, 22:262-278.
23. Carbonell A.L., Boya J. Ultrastructural study on meningeal regeneration and meningo-glial relationships after cerebral stab wound in the adult rat. Brain Res 1988, 439:337-344.
24. Caroni P., Schwab M.E. Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron 1988, 1:85-96.
25. Caroni P., Schwab M.E. Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading. J Cell Biol 1988, 106:1281-1288.
26. Carulli D., Rhodes K.E., Brown D.J., et al. The composition of perineuronal nets in the adult rat cerebellum and the cellular origin of their components. J Comp Neurol 2006, 494:559-577.
27. Carulli D., Deepa S.S., Fawcett J.W. Upregulation of aggrecan, link protein 1 and hyaluronan synthases during formation of perineuronal nets in the rat cerebellum. J Comp Neurol 2007, 501:83-94.
28. Chaisuksunt V., Zhang Y., Anderson P.N., et al. Axonal regeneration from CNS neurons in the cerebellum and brainstem of adult rats: correlation with the patterns of expression and distribution of messenger RNAs for L1, CHL1, c-jun and growth-associated protein-43. Neuroscience 2000, 100:87-108.
29. Chen M.S., Huber A.B., van der Haar M.E., et al. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 2000, 403:434-439.
30. Chen J., Wu J., Apostolova I., et al. Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury. Brain 2007, 130:954-969.
31. Condic M.L., Lemons M.L. Extracellular matrix in spinal cord regeneration: getting beyond attraction and inhibition. Neuroreport 2002, 13:A37-A48.
32. Cramer S.C., Riley J.D. Neuroplasticity and brain repair after stroke. Curr Opin Neurol 2008, 21:76-82.
33. Crespo D., Asher R.A., Lin R., et al. How does chondroitinase promote functional recovery in the damaged CNS?. Exp Neurol 2007, 206:159-171.
34. David S., Aguayo A.J. Axonal elongation into peripheral nervous system " bridges" after central nervous system injury in adult rats. Science 1981, 214:931-933.
35. Davies S.J., Fitch M.T., Memberg S.P., et al. Regeneration of adult axons in white matter tracts of the central nervous system. Nature 1997, 390:680-683.
36. Davies S.J., Goucher D.R., Doller C., et al. Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J Neurosci 1999, 19:5810-5822.
37. Davies J.E., Tang X., Denning J.W., et al. Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuries. Eur J Neurosci 2004, 19:1226-1242.
38. Davies J.E., Huang C., Proschel C., et al. Astrocytes derived from glial-restricted precursors promote spinal cord repair. J Biol 2006, 5:7.
39. de Castro R., Tajrishi R., Claros J., et al. Differential responses of spinal axons to transection: influence of the NG2 proteoglycan. Exp Neurol 2005, 192:299-309.
40. De Winter F., Oudega M., Lankhorst A.J., et al. Injury-induced class 3 semaphorin expression in the rat spinal cord. Exp Neurol 2002, 175:61-75.
41. Deepa S.S., Carulli D., Galtrey C., et al. Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. J Biol Chem 2006, 281:17789-17800.
42. Dietz V., Colombo G. Recovery from spinal cord injury - underlying mechanisms and efficacy of rehabilitation. Acta Neurochir Suppl 2004, 89:95-100.
43. Dietz V., Wirz M., Curt A., et al. Locomotor pattern in paraplegic patients: training effects and recovery of spinal cord function. Spinal Cord 1998, 36:380-390.
44. Dietz V., Wirz M., Colombo G., et al. Locomotor capacity and recovery of spinal cord function in paraplegic patients: a clinical and electrophysiological evaluation. Electroencephalogr Clin Neurophysiol 1998, 109:140-153.
45. Dimou L., Schnell L., Montani L., et al. Nogo-A-deficient mice reveal strain-dependent differences in axonal regeneration. J Neurosci 2006, 26:5591-5603.
46. Dodd D.A., Niederoest B., Bloechlinger S., et al. Nogo-A, -B, and -C are found on the cell surface and interact together in many different cell types. J Biol Chem 2005, 280:12494-12502.
47. Domeniconi M., Cao Z., Spencer T., et al. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron 2002, 35:283-290.
48. Duncan M.R., Frazier K.S., Abramson S., et al. Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J 1999, 13:1774-1786.
49. Eberhart J., Barr J., O'Connell S., et al. Ephrin-A5 exerts positive or inhibitory effects on distinct subsets of EphA4-positive motor neurons. J Neurosci 2004, 24:1070-1078.
50. Edgerton V.R., Tillakaratne N.J., Bigbee A.J., et al. Plasticity of the spinal neural circuitry after injury. Annu Rev Neurosci 2004, 27:145-167.
51. Edgerton V.R., Kim S.J., Ichiyama R.M., et al. Rehabilitative therapies after spinal cord injury. J Neurotrauma 2006, 23:560-570.
52. Edgerton V.R., Courtine G., Gerasimenko Y.P., et al. Training locomotor networks. Brain Res Rev 2008, 57:241-254.
53. El M.A., Petridis A.K., Rutishauser U. Use of polysialic acid in repair of the central nervous system. Proc Natl Acad Sci U S A 2006, 103:16989-16994.
54. Elbert T., Flor H., Birbaumer N., et al. Extensive reorganization of the somatosensory cortex in adult humans after nervous system injury. Neuroreport 1994, 5:2593-2597.
55. Eleftheriades E.G., Ferguson A.G., Spragia M.L., et al. Prolyl hydroxylation regulates intracellular procollagen degradation in cultured rat cardiac fibroblasts. J MolCell Cardiol 1995, 27:1459-1473.
56. Fabes J., Anderson P., Brennan C., et al. Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord. Eur J Neurosci 2007, 26:2496-2505.
57. Faulkner J.R., Herrmann J.E., Woo M.J., et al. Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci 2004, 24:2143-2155.
58. Fawcett J.W. Overcoming inhibition in the damaged spinal cord. J Neurotrauma 2006, 23:371-383.
59. Fawcett J.W. The CNS glial scar 2006, in Encyclopedia of Neuroscience, Ed Squire LR, Elsevier 2008.
60. Fidler P.S., Schuette K., Asher R.A., et al. Comparing astrocytic cells lines that are inhibitory or permissive for axon growth: the major axon-inhibitory proteoglycan is NG2. J Neurosci 1999, 19:8778-8788.
61. Fiedler M., Horn C., Bandtlow C., et al. An engineered IN-1 F(ab) fragment with improved affinity for the Nogo-A axonal growth inhibitor permits immunochemical detection and shows enhanced neutralizing activity. Protein Eng 2002, 15:931-941.
62. Fischer D., He Z., Benowitz L.I. Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state. J Neurosci 2004, 24:1646-1651.
63. Fouad K., Tse A. Adaptive changes in the injured spinal cord and their role in promoting functional recovery. Neurol Res 2008, 30:17-27.
64. Fouad K., Pedersen V., Schwab M.E., et al. Cervical sprouting of corticospinal fibers after thoracic spinal cord injury accompanies shifts in evoked motor responses. Curr Biol 2001, 11:1766-1770.
65. Fouad K., Klusman I., Schwab M.E. Regenerating corticospinal fibers in the Marmoset (Callitrix jacchus) after spinal cord lesion and treatment with the anti-Nogo-A antibody IN-1. Eur J Neurosci 2004, 2004(9):2479-2482.
66. Fouad K., Schnell L., Bunge M.B., et al. Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. J Neurosci 2005, 25:1169-1178.
67. Fournier A.E., GrandPre T., Strittmatter S.M. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 2001, 409:341-346.
68. Fournier A.E., Gould G.C., Liu B.P., et al. Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin. J Neurosci 2002, 22:8876-8883.
69. Freund P., Schmidlin E., Wannier T., et al. Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates. Nat Med 2006, 12:790-792.
70. Freund P., Wannier T., Schmidlin E., et al. Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey. J Comp Neurol 2007, 502:644-659.
71. Galtrey C.M., Fawcett J.W. The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system. Brain Res Reviews 2007, 54:1-18.
72. Galtrey C.M., Asher R.A., Nothias F., et al. Promoting plasticity in the spinal cord with chondroitinase improves functional recovery after peripheral nerve repair. Brain 2007, 130:926-939.
73. Garcia-Alias G., Lin R., Akrimi S.F., et al. Therapeutic time window for the application of chondroitinase ABC after spinal cord injury. Exp Neurol 2008, 210:331-338.
74. Gaze R.M. The formation of nerve connections 1970, Academic Press.
75. Girgis J., Merrett D., Kirkland S., et al. Reaching training in rats with spinal cord injury promotes plasticity and task specific recovery. Brain 2007, 130:2993-3003.
76. Goldberg J.L., Vargas M.E., Wang J.T., et al. An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells. J Neurosci 2004, 24:4989-4999.
77. Goldshmit Y., Galea M.P., Wise G., et al. Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice. J Neurosci 2004, 24:10064-10073.
78. Gonzenbach R., Schwab M.E. Disinhibition of neurite growth to repair the injured adult CNS: focusing on Nogo. Cell Mol Life Sci 2008, 65:161-176.
79. GrandPre T., Nakamura F., Vartanian T., et al. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 2000, 403:439-444.
80. GrandPre T., Li S., Strittmatter S.M. Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 2002, 417:547-551.
81. Grimpe B., Silver J. The extracellular matrix in axon regeneration. Prog Brain Res 2002, 137:333-349.
82. Grimpe B., Silver J. A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord. J Neurosci 2004, 24:1393-1397.
83. Gulino R., Dimartino M., Casabona A., et al. Synaptic plasticity modulates the spontaneous recovery of locomotion after spinal cord hemisection. Neurosci Res 2007, 57:148-156.
84. Guth L., Albuquerque E.X., Deshpande S.S., et al. Ineffectiveness of enzyme therapy on regeneration in the transected spinal cord of the rat. J Neurosurg 1980, 52:73-86.
85. Habib A.A., Marton L.S., Allwardt B., et al. Expression of the oligodendrocyte-myelin glycoprotein by neurons in the mouse central nervous system. J Neurochem 1998, 70:1704-1711.
86. Hains B.C., Black J.A., Waxman S.G. Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury. J Comp Neurol 2003, 462:328-341.
87. Hasegawa K., Chang Y.W., Li H., et al. Embryonic radial glia bridge spinal cord lesions and promote functional recovery following spinal cord injury. Exp Neurol 2005, 193:394-410.
88. Hensch T.K. Critical period regulation. Annu Rev Neurosci 2004, 27:549-579.
89. Hensch T.K. Critical period plasticity in local cortical circuits. Nat Rev Neurosci 2005, 6:877-888.
90. Hermanns S., Klapka N., Müller H.W. The collagenous lesion scar - an obstacle for axonal regeneration in brain and spinal cord injury. Restor Neurol Neurosci 2001, 19:139-148.
91. Hermanns S., Müller H.W. Preservation and detection of lesion-induced collagenous scar in the CNS depend on the method of tissue processing. Brain Res Brain Res Protoc 2001, 7:162-167.
92. Hermanns S., Reiprich P., Müller H.W. A reliable method to reduce collagen scar formation in the lesioned rat spinal cord. J Neurosci Methods 2001, 110:141-146.
93. Hermanns S., Klapka N., Gasis M., et al. The collagenous wound healing scar in the injured central nervous system inhibits axonal regeneration. Adv Exp Med Biol 2006, 557:177-190.
94. Houle J.D., Tom V.J., Mayes D., et al. Combining an autologous peripheral nervous system " bridge" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord. J Neurosci 2006, 26:7405-7415.
95. Huber A.B., Weinmann O., Brosamle C., et al. Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions. J Neurosci 2002, 22:3553-3567.
96. Iannotti C., Zhang Y.P., Shields L.B., et al. Dural repair reduces connective tissue scar invasion and cystic cavity formation after acute spinal cord laceration injury in adult rats. J Neurotrauma 2006, 23:853-865.
97. Ito Y., Hikino M., Yajima Y., et al. Structural characterization of the epitopes of the monoclonal antibodies 473HD, CS-56, and MO-225 specific for chondroitin sulfate D-type using the oligosaccharide library. Glycobiology 2005, 15:593-603.
98. Jenkins R., Tetzlaff W., Hunt S.P. Differential expression of immediate early genes in rubrospinal neurons following axotomy in rat. Eur J Neurosci 1993, 5:203-209.
99. Ji B., Li M., Wu W.T., et al. LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury. Mol Cell Neurosci 2006, 33:311-320.
100. Joester A., Faissner A. The structure and function of tenascins in the nervous system. Matrix Biol 2001, 20:13-22.
101. Jones L.L., Yamaguchi Y., Stallcup W.B., et al. NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J Neurosci 2002, 22:2792-2803.
102. Jones L.L., Margolis R.U., Tuszynski M.H. The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol 2003, 182:399-411.
103. Jurkiewicz M.T., Mikulis D.J., McIlroy W.E., et al. Sensorimotor cortical plasticity during recovery following spinal cord injury: a longitudinal fMRI study. Neurorehabil Neural Repair 2007, 21:527-538.
104. Kaas J.H., Qi H.X., Burish M.J., et al. Cortical and subcortical plasticity in the brains of humans, primates, and rats after damage to sensory afferents in the dorsal columns of the spinal cord. Exp Neurol 2008, 209:407-416.
105. Kawano H., Li H.P., Sango K., et al. Inhibition of collagen synthesis overrides the age-related failure of regeneration of nigrostriatal dopaminergic axons. J Neurosci Res 2005, 80:191-202.
106. Kim J.E., Li S., GrandPre T., et al. Axon regeneration in young adult mice lacking Nogo-A/B. Neuron 2003, 38:187-199.
107. Kim J.E., Liu B.P., Park J.H., et al. Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron 2004, 44:439-451.
108. Kim B.G., Dai H.N., McAtee M., et al. Remodeling of synaptic structures in the motor cortex following spinal cord injury. Exp Neurol 2006, 198:401-415.
109. Klapka N., Müller H.W. Collagen matrix in spinal cord injury. J Neurotrauma 2006, 23:422-436.
110. Klapka N., Hermanns S., Straten G., et al. Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery. Eur J Neurosci 2005, 22:3047-3058.
111. Koppe G., Bruckner G., Brauer K., et al. Developmental patterns of proteoglycan-containing extracellular matrix in perineuronal nets and neuropil of the postnatal rat brain. Cell Tissue Res 1997, 288:33-41.
112. Kottis V., Thibault P., Mikol D., et al. Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth. J Neurochem 2002, 82:1566-1569.
113. Kühn K. Basement membrane (type IV) collagen. Matrix Biol 1994, 14:439-445.
114. Laabs T.L., Wang H., Katagiri Y., et al. Inhibiting glycosaminoglycan chain polymerization decreases the inhibitory activity of astrocyte-derived chondroitin sulfate proteoglycans. J Neurosci 2007, 27:14494-14501.
115. Lagord C., Berry M., Logan A. Expression of TGFbeta2 but not TGFbeta1 correlates with the deposition of scar tissue in the lesioned spinal cord. Mol Cell Neurosci 2002, 20:69-92.
116. Lang D.M., Rubin B.P., Schwab M.E., et al. CNS myelin and oligodendrocytes of the Xenopus spinal cord - but not optic nerve - are nonpermissive for axon growth. J Neurosci 1995, 15:99-109.
117. Li W.W., Yew D.T., Chuah M.I., et al. Axonal sprouting in the hemisected adult rat spinal cord. Neuroscience 1994, 61:133-139.
118. Li S., Strittmatter S.M. Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury. J Neurosci 2003, 23:4219-4227.
119. Li M., Shibata A., Li C., et al. Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse. J Neurosci Res 1996, 46:404-414.
120. Li S., Liu B.P., Budel S., et al. Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury. J Neurosci 2004, 24:10511-10520.
121. Li H.P., Homma A., Sango K., et al. Regeneration of nigrostriatal dopaminergic axons by degradation of chondroitin sulfate is accompanied by elimination of the fibrotic scar and glia limitans in the lesion site. J Neurosci Res 2007, 85:536-547.
122. Liebscher T., Schnell L., Schnell D., et al. Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Ann Neurol 2005, 58:706-719.
123. Liesi P., Kauppila T. Induction of type IV collagen and other basement-membrane-associated proteins after spinal cord injury of the adult rat may participate in formation of the glial scar. Exp Neurol 2002, 173:31-45.
124. Lin R., Kwok J.C., Crespo D. Chondroitinase ABC has a long lasting effect on chondroitin sulphate glycosaminoglycan content in the injured rat brain. J Neurochem 2008, 104:400-408.
125. Liu B.P., Fournier A., GrandPre T., et al. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 2002, 297:1190-1193.
126. Liu D., Liu J., Sun D., et al. The time course of hydroxyl radical formation following spinal cord injury: the possible role of the iron-catalyzed Haber-Weiss reaction. J Neurotrauma 2004, 21:805-816.
127. Llewellyn-Smith I.J., Weaver L.C. Changes in synaptic inputs to sympathetic preganglionic neurons after spinal cord injury. J Comp Neurol 2001, 435:226-240.
128. Logan A., Baird A., Berry M. Decorin attenuates gliotic scar formation in the rat cerebral hemisphere. Exp Neurol 1999, 159:504-510.
129. Lundborg G. Richard P. Bunge memorial lecture. Nerve injury and repair - a challenge to the plastic brain. J Peripher Nerv Syst 2003, 8:209-226.
130. Lyon M.J., Stelzner D.J. Tests of the regenerative capacity of tectal efferent axons in the frog, Rana pipiens. J Comp Neurol 1987, 255:511-525.
131. McGee A.W., Yang Y., Fischer Q.S., et al. Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor. Science 2005, 309:2222-2226.
132. McKerracher L., David S., Jackson D.L., et al. Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron 1994, 13:805-811.
133. Maffei A., Turrigiano G. The age of plasticity: developmental regulation of synaptic plasticity in neocortical microcircuits. Prog Brain Res 2008, 169:211-223.
134. Maier I.C., Schwab M.E. Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity. Philos Trans R Soc Lond B Biol Sci 2006, 361:1611-1634.
135. Maier I.C., Baumann K., Thallmair M., et al. Constraint induced movement therapy (CIMS) in the adult rat after unilateral corticospinal tract injury. J Neurosci 2008, 28:9386-9403.
136. Massey J.M., Hubscher C.H., Wagoner M.R., et al. Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury. J Neurosci 2006, 26:4406-4414.
137. Matinian LA, Andreasian AS (1973). Akademia Nauk Armenian SSR. English translation Enzyme therapy in organic lesions of the spinal cord. Brain Information Service, University of California, Los Angeles 1976: 156.
138. Maxwell W.L., Duance V.C., Lehto M., et al. The distribution of types I, III, IV and V collagens in penetrant lesions of the central nervous system of the rat. Histochem J 1984, 16:1215-1229.
139. Merkler D., Metz G.A., Raineteau O., et al. Locomotor recovery in spinal cord-injured rats treated with an antibody neutralizing the myelin-associated neurite growth inhibitor Nogo-A. J Neurosci 2001, 21:3665-3673.
140. Metz G.A., Whishaw I.Q. Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination. J Neurosci Methods 2002, 115:169-179.
141. Mi S., Lee X., Shao Z., et al. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci 2004, 7:221-228.
142. Mikol D.D., Gulcher J.R., Stefansson K. The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate. J Cell Biol 1990, 110:471-479.
143. Moon L.D.F., Fawcett J.W. Partial reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to transforming growth factors beta1 and beta2. Eur J Neurosci 2001, 14:1667-1677.
144. Moon L.D.F., Brecknell J.E., Franklin R.J.M., et al. Robust regeneration of CNS axons through a track depleted of CNS glia. Exp Neurol 1999, 161:49-66.
145. Moon L.D.F., Asher R.A., Rhodes K.E., et al. Regeneration of CNS axons back to their original target following treatment of adult rat brain with chondroitinase ABC. Nat Neurosci 2001, 4:465-466.
146. Moon L.D., Asher R.A., Rhodes K.E., et al. Relationship between sprouting axons, proteoglycans and glial cells following unilateral nigrostriatal axotomy in the adult rat. Neurosci 2002, 109:101-117.
147. Mora F., Segovia G., del Arco A. Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain. Brain Res Rev 2007, 55:78-88.
148. Moreau-Fauvarque C., Kumanogoh A., Camand E., et al. The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion. J Neurosci 2003, 23:9229-9239.
149. Morgenstern D.A., Asher R.A., Fawcett J.W. Chondroitin sulphate proteoglycans in the CNS injury response. Prog Brain Res 2002, 137:313-332.
150. Morishita H., Hensch T.K. Critical period revisited: impact on vision. Curr Opin Neurobiol 2008, 18:101-107.
151. Mukhopadhyay G., Doherty P., Walsh F.S., et al. A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 1994, 13:757-767.
152. Mullner A., Gonzenbach R.R., Weinmann O., et al. Lamina-specific restoration of serotonergic projections after Nogo-A antibody treatment of spinal cord injury in rats. Eur J Neurosci 2008, 27:326-333.
153. Niclou S.P., Franssen E.H., Ehlert E.M., et al. Meningeal cell-derived semaphorin 3A inhibits neurite outgrowth. Mol Cell Neurosci 2003, 24:902-912.
154. Niclou S.P., Ehlert E.M.E., Verhaagen J. Chemorepellent axon guidance molecules in spinal cord injury. J Neurotrauma 2006, 23:409-421.
155. Oertle T., Huber C., van der Putten H., et al. Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4. J Mol Biol 2003, 325:299-323.
156. Oertle T., van der Haar M.E., Bandtlow C.E., et al. Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions. J Neurosci 2003, 23:5393-5406.
157. Okada S., Nakamura M., Katoh H., et al. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med 2006, 12:829-834.
158. Park J.B., Yiu G., Kaneko S., et al. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron 2005, 45:345-351.
159. Pearse D.D., Pereira F.C., Marcillo A.E., et al. cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat Med 2004, 10:610-616.
160. Pizzorusso T., Medini P., Berardi N., et al. Reactivation of ocular dominance plasticity in the adult visual cortex with chondroitinase ABC. Science 2002, 298:1248-1251.
161. Pizzorusso T., Medini P., Landi S., et al. Structural and functional recovery from early monocular deprivation in adult rats. Proc Natl Acad Sci U S A 2006, 103:8517-8522.
162. Prinjha R., Moore S.E., Vinson M., et al. Inhibitor of neurite outgrowth in humans. Nature 2000, 403:383-384.
163. Properzi F., Carulli D., Asher R.A., et al. Chondroitin 6-sulphate synthesis is up-regulated in injured CNS, induced by injury-related cytokines and enhanced in axon-growth inhibitory glia. Eur J Neurosci 2005, 21:378-390.
164. Raineteau O., Schwab M.E. Plasticity of motor systems after incomplete spinal cord injury. Nat Rev Neurosci 2001, 2:263-273.
165. Raineteau O., Z'Graggen W.J., Thallmair M., et al. Sprouting and regeneration after pyramidotomy and blockade of the myelin-associated neurite growth inhibitors NI 35/250 in adult rats. Eur J Neurosci 1999, 11:1486-1490.
166. Raineteau O., Fouad K., Noth P., et al. Functional switch between motor tracts in the presence of the mAb IN-1 in the adult rat. Proc Natl Acad Sci U S A 2001, 98:6929-6934.
167. Ramón y Cajal S., May R.M. Estudios sobre la degeneración y regeneración del sistema nervioso. Degeneration and Regeneration of the Nervous System 1928, Vol. 2:xx. Humphrey Milford, London, viii, 769. R.M. May (Ed.).
168. Reier P.J., Bregman B.S., Wujek J.R. Intraspinal transplantation of embryonic spinal cord tissue in neonatal and adult rats. J Comp Neurol 1986, 247:275-296.
169. Sandvig A., Berry M., Barrett L.B., et al. Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration. Glia 2004, 46:225-251.
170. Savio T., Schwab M.E. Rat CNS white matter, but not gray matter, is nonpermissive for neuronal cell adhesion and fiber outgrowth. J Neurosci 1989, 9:1126-1133.
171. Savio T., Schwab M.E. Lesioned corticospinal tract axons regenerate in myelin-free rat spinal cord. Proc Natl Acad Sci U S A 1990, 87:4130-4133.
172. Schachtrup C., Lu P., Jones L.L., et al. Fibrinogen inhibits neurite outgrowth via beta 3 integrin-mediated phosphorylation of the EGF receptor. Proc Natl Acad Sci U S A 2007, 104:11814-11819.
173. Schiwy N., Brazda N., Müller H.W. Enhanced regenerative axon growth of multiple fibre populations in traumatic spinal cord injury following scar-suppressing treatment. Eur J Neurosci 2009, 30:1544-1553.
174. Schnell L., Schwab M.E. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature 1990, 343:269-272.
175. Schnell L., Schwab M.E. Sprouting and regeneration of lesioned corticospinal tract fibres in the adult rat spinal cord. Eur J Neurosci 1993, 5:1156-1171.
176. Schnell L., Schneider R., Kolbeck R., et al. Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion [see comments]. Nature 1994, 367:170-173.
177. Schwab M.E. Nogo and axon regeneration. Curr Opin Neurobiol 2004, 14:118-124.
178. Schwab M.E., Caroni P. Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro. J Neurosci 1988, 8:2381-2393.
179. Schwab M.E., Thoenen H. Dissociated neurons regenerate into sciatic but not optic nerve explants in culture irrespective of neurotrophic factors. J Neurosci 1985, 5:2415-2423.
180. Schwab J.M., Beschorner R., Nguyen T.D., et al. Differential cellular accumulation of connective tissue growth factor defines a subset of reactive astrocytes, invading fibroblasts, and endothelial cells following central nervous system injury in rats and humans. J Neurotrauma 2001, 18:377-388.
181. Shao Z., Browning J.L., Lee X., et al. TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Neuron 2005, 45:353-359.
182. Shearer M.C., Fawcett J.W. The astrocyte/meningeal cell interface - a barrier to successful nerve regeneration?. Cell Tissue Res 2001, 305:267-273.
183. Silver J., Miller J.H. Regeneration beyond the glial scar. Nat Rev Neurosci 2004, 5:146-156.
184. Simonen M., Pedersen V., Weinmann O., et al. Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 2003, 38:201-211.
185. Snow D.M., Lemmon V., Carrino D.A., et al. Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro. Exp Neurol 1990, 109:111-130.
186. Song X.Y., Zhong J.H., Wang X., et al. Suppression of p75NTR does not promote regeneration of injured spinal cord in mice. J Neurosci 2004, 24:542-546.
187. Spillmann A.A., Bandtlow C.E., Lottspeich F., et al. Identification and characterization of a bovine neurite growth inhibitor (bNI-220). J Biol Chem 1998, 273:19283-19293.
188. Stichel C.C., Müller H.W. The CNS lesion scar: new vistas on an old regeneration barrier. Cell Tissue Res 1998, 294:1-9.
189. Stichel C.C., Hermanns S., Luhmann H.J., et al. Inhibition of collagen IV deposition promotes regeneration of injured CNS axons. Eur J Neurosci 1999, 11:632-646.
190. Stichel C.C., Niermann H., D'Urso D., et al. Basal membrane-depleted scar in lesioned CNS: characteristics and relationships with regenerating axons. Neurosci 1999, 93:321-333.
191. Sugahara K., Mikami T., Uyama T., et al. Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate. Curr Opin Struct Biol 2003, 13:612-620.
192. Tan A.M., Zhang W., Levine J.M. NG2: a component of the glial scar that inhibits axon growth. J Anat 2005, 207:717-725.
193. Tan A.M., Colletti M., Rorai A.T., et al. Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord. J Neurosci 2006, 26:4729-4739.
194. Tang S., Qiu J., Nikulina E., et al. Soluble myelin-associated glycoprotein released from damaged white matter inhibits axonal regeneration. Mol Cell Neurosci 2001, 18:259-269.
195. Tang X., Davies J.E., Davies S.J. Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. J Neurosci Res 2003, 71:427-444.
196. Tello F. La influencia del neurotropismo en la regeneracion de los centros nerviosos. Trab Lab Invest Biol 1911, 9:123-159.
197. Teng X., Nagata I., Li H.P., et al. Regeneration of nigrostriatal dopaminergic axons after transplantation of olfactory ensheathing cells and fibroblasts prevent fibrotic scar formation at the lesion site. J Neurosci Res 2008, 86:3140-3150.
198. Thallmair M., Metz G.A., Z'Graggen W.J., et al. Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions. Nat Neurosci 1998, 1:124-131.
199. Timpl R. Structure and biological activity of basement membrane proteins. Eur J Biochem 1989, 180:487-502.
200. Walmsley A.R., Mir A.K. Targeting the Nogo-A signalling pathway to promote recovery following acute CNS injury. Curr Pharm Des 2007, 13:2470-2484.
201. Wang K.C., Kim J.A., Sivasankaran R., et al. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature 2002, 420:74-78.
202. Wang K.C., Koprivica V., Kim J.A., et al. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 2002, 417:941-944.
203. Wang X., Chun S.J., Treloar H., et al. Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact. J Neurosci 2002, 22:5505-5515.
204. Wang X., Baughman K.W., Basso D.M., et al. Delayed Nogo receptor therapy improves recovery from spinal cord contusion. Ann Neurol 2006, 60:540-549.
205. Wannier T., Schmidlin E., Bloch J., et al. A unilateral section of the corticospinal tract at cervical level in primate does not lead to measurable cell loss in motor cortex. J Neurotrauma 2005, 22:703-717.
206. Wehrle R., Camand E., Chedotal A., et al. Expression of netrin-1, slit-1 and slit-3 but not of slit-2 after cerebellar and spinal cord lesions. Eur J Neurosci 2005, 22:2134-2144.
207. Weidner N., Ner A., Salimi N., et al. Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury. Proc Natl Acad Sci U S A 2001, 98:3513-3518.
208. Weinmann O., Schnell L., Ghosh A., et al. Intrathecally infused antibodies against Nogo-A penetrate the CNS and downregulate the endogenous neurite growth inhibitor Nogo-A. Mol Cell Neurosci 2006, 32:161-173.
209. Whishaw I.Q., Metz G.A. Absence of impairments or recovery mediated by the uncrossed pyramidal tract in the rat versus enduring deficits produced by the crossed pyramidal tract. Behav Brain Res 2002, 134:323-336.
210. Wong S.T., Henley J.R., Kanning K.C., et al. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nat Neurosci 2002, 5:1302-1308.
211. Yurchenco P.D., Schittny J.C. Molecular architecture of basement membranes. FASEB J 1990, 4:1577-1590.
212. Z'Graggen W.J., Metz G.A., Kartje G.L., et al. Functional recovery and enhanced corticofugal plasticity after unilateral pyramidal tract lesion and blockade of myelin-associated neurite growth inhibitors in adult rats. J Neurosci 1998, 18:4744-4757.
213. Zeman R.J., Feng Y., Peng H., et al. X-irradiation of the contusion site improves locomotor and histological outcomes in spinal cord-injured rats. Exp Neurol 2001, 172:228-234.
214. Zhang S.X., Geddes J.W., Owens J.L., et al. X-irradiation reduces lesion scarring at the contusion site of adult rat spinal cord. Histol Histopathol 2005, 20:519-530.
215. Zhang Y., Ghadiri-Sani M., Zhang X., et al. Induced expression of polysialic acid in the spinal cord promotes regeneration of sensory axons. Mol Cell Neurosci 2007, 35:109-119.
216. Zheng B., Ho C., Li S., et al. Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron 2003, 38:213-224.
217. Zheng B., Atwal J., Ho C., et al. Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A 2005, 102:1205-1210.