Mouse-based phenogenomics for modelling human disease

Trends in Molecular Medicine

Volumn 7, Issue 11, 2001, Pages 502-507

  Rossant, Janet ^a   McKerlie, Colin ^b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE MODEL; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HEALTH PROGRAM; HUMAN; MOLECULAR CLONING; MOUSE; MUTAGENESIS; NONHUMAN; PHENOTYPE; REVIEW; STRAIN DIFFERENCE;

ACADEMIES AND INSTITUTES; ANIMALS; DISEASE MODELS, ANIMAL; GENOMICS; HUMANS; LABORATORIES; MICE; MUTAGENESIS;

EID: 0034753463     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(01)02164-5     Document Type: Review

References (43)

1. Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase
2. Finding the molecular basis of quantitative traits: Successes and pitfalls
3. A major effect QTL determined by multiple genes in epileptic EL mice
4. Mouse models of human disease. Part II: Recent progress and future directions
5. Ten years of gene targeting: Targeted mouse mutants, from vector design to phenotype analysis
6. Comprehensive mammalian genetics: History and future prospects of gene trapping in the mouse
7. Gene and enhancer trapping: Mutagenic strategies for developmental studies
8. Expression trapping: Identification of novel genes expressed in hematopoietic and endothelial lineages by gene trapping in ES cells
9. Functional analysis of secreted and transmembrane proteins critical to mouse development
10. Functional genomics in mice by tagged sequence mutagenesis
11. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse
12. Genome-wide, large-scale production of mutant mice by ENU mutagenesis
13. Effects of ENU dosage on mouse strains
14. A genomic view of immunology
15. A phenotype-based screen for embryonic lethal mutations in the mouse
16. Mouse ENU mutagenesis
17. Positional cloning of the mouse circadian clock gene
18. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
19. Toward the yeastification of mouse genetics: Chemical mutagenesis of embryonic stem cells
20. The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: Screening for clinically relevant phenotypes
21. Special considerations in the evaluation of the hematology and hemostasis of mutant mice
22. Implementation of a large-scale ENU mutagenesis program: Towards increasing the mouse mutant resource
23. Screening for dysmorphological abnormalities - A powerful tool to isolate new mouse mutants
24. Precision and accuracy of dual-energy X-ray absorptiometry for determining in vivo body composition of mice
25. A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice
26. Dissection of behavior and psychiatric disorders using the mouse as a model
27. Behavior and mutagenesis screens: The importance of baseline analysis of inbred strains
28. Comet assay as a tool to screen for mouse models with inherited radiation sensitivity
29. The developmental biology of brain tumors
30. The world according to hedgehog
31. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
32. Evaluating mutant mice: Anatomic pathology
33. Magnetic resonance microscopy in basic studies of brain structure and function
34. Magnetic resonance microscopy of the C57BL mouse brain
35. High resolution X-ray computed tomography: An emerging tool for small animal cancer research
36. Advances in ultrasound biomicroscopy
37. Expression profiling using cDNA microarrays
38. Genomics meets genetics: Towards a mutant map of the mouse
39. Cryopreservation of mouse spermatozoa
40. Cryopreservation of murine spermatozoa
41. Cryoconservation - Archiving for the future
42. Sequence interpretation. Functional annotation of mouse genome sequences