Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection

Experimental Neurology

Volumn 139, Issue 2, 1996, Pages 244-256

  Basso, D Michele ^a   Beattie, Michael S ^a   Bresnahan, Jacqueline C ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONTUSION; FEMALE; HISTOLOGY; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION;

EID: 0030157694     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1996.0098     Document Type: Article

References (41)

1. 1. BASSO, D. M., M. S. BEATTIE, AND J. C. BRESNAHAN. 1995. A sensitive and reliable locomotor rating scale for open field testing in rats. J. Neurotrauma 12: 1-21.
2. 2. BASSO, D. M., M. S. BEATTIE, J. C. BRESNAHAN, D. ANDERSON, A. I. FADEN, J. A. GRUNER, T. HOLFORD, C. Y. HSU, L. J. NOBLE, R. NOCKLES, P. L. PEROT, JR., S. K. SALZMAN, AND W. YOUNG. 1996. Multicenter analysis of BBB locomotor scores: Role of experience, teamwork, and field conditions on reliability. J. Neurotrauma, in press.
3. 3. BASSO, D. M., J. C. BRESNAHAN, AND M. S. BEATTIE. 1993. Incomplete recovery after spinal cord contusion is associated with a nearly complete loss of vestibulospinal system (VSS) and long descending propriospinal neurons (LDPN) in rats. Soc. Neurosci. Abstr. 19: 541.
4. 4. BASSO, D. M., M. MURRAY, AND M. E. GOLDBERGER. 1994. Differential recovery of bipedal and overground locomotion following complete spinal cord hemisection in cats. Restor. Neurol. Neurosci. 7: 95-110.
5. 5. BASSO, D. M., M. VAN METER, M. S. BEATTIE, AND J. C. BRESNAHAN. 1994. Differential sparing of rubrospinal and vestibulospinal tracts after mild or moderate spinal cord contusion in rats. Soc. Neurosci. 20: 147.
6. 6. BEATTIE, M. S., AND J. C. BRESNAHAN. 1989. Longitudinal assessment of recovery of locomotor function in rats after feedback-controlled spinal cord impact lesions. Pages 16-25 in M. Brown and M. E. Goldberger, Eds., Conference Proceedings: Criteria for Assessing Recovery of Function: Behavioral Methods. American Paralysis Association, Springfield, NJ.
7. 7. BEATTIE, M. S., B. T. STOKES, AND J. C. BRESNAHAN. 1988. Experimental spinal cord injury: Strategies for acute and chronic intervention based on anatomic, physiological, and behavioral studies. Pages 43-74 in D. G. Stein and B. A. Sabel, Eds., Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury. Plenum, New York.
8. 8. BEHRMANN, D. L., J. C. BRESNAHAN, AND M. S. BEATTIE. 1993. A comparison of YM-14673, U-50488H, and nalmefene after spinal cord injury in the rat. Exp. Neuraol. 119: 258-267.
9. 9. BEHRMANN, D. L., J. C. BRESNAHAN, AND M. S. BEATTIE. 1994. Modeling of acute spinal cord injury in the rat: Neuroprotection and enhanced recovery with Methylprednisolone, U-74006F and YM-14673. Exp. Neurol. 126: 1-16.
10. 10. BEHRMANN, D. L., J. C. BRESNAHAN, M. S. BEATTIE, AND B. R. SHAH. 1992. Spinal cord injury produced by consistent mechanical displacement of the cord in rats: Behavioral and histological analysis. J. Neurotrauma 9: 197-217.
11. 11. BLACK, P., R. S. MARKOWITZ, V. COOPER, A. MECHANIC, H. KUSHNER, I. DAMJANOV, S. D. FINKELSTEIN, AND K. WACHS. 1986. Models of spinal cord injury: Part 1. Static load technique. Neurosurgery 19: 752-762.
12. 12. BRACKEN, M. B., M. J. SHEPARD, W. F. COLLINS, T. R. HOLFORD, J. S. BASKIN, H. M. EISENBERG, E. FLAMM, L. LEO-SUMMERS, J. C. MAROON, L. F. MARSHALL, P. L. PEROT, J. PIEPMEIER, V. K. H. SONNTAG, F. C. WAGNER, J. L. WILBERGER, H. R. WINN, AND W. YOUNG. 1992. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data: Results of the second National Acute Spinal Cord Injury Study. J. Neurosurg. 76: 23-31.
13. 13. BRACKEN, M. B., M. J. SHEPARD, W. F. COLLINS, T. R. HOLFORD, W. YOUNG, J. S. BASKIN, H. M. EISENBERG, E. FLAMM, L. LEO-SUMMERS, J. C. MAROON, et al. 1990. A randomized controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. N. Engl. J. Med. 322: 1405-1461.
14. 14. BRAUGHLER, J. M., E. D. HALL, E. D. MEANS, T. R. WATERS, AND D. K. ANDERSON. 1987. Evaluation of an intensive methylprednisolone sodium succinate dosing regimen in experimental spinal cord injury. J. Neurosurg. 67: 102-105.
15. 15. BRESNAHAN, J. C. 1978. An electron-microscopic analysis of axonal alterations following blunt contusion of the spinal cord of the rhesus monkey (Macaca mulatta). J. Neurol. Sci. 37: 59-82.
16. 16. BRESNAHAN, J. C., M. S. BEATTIE, B. T. STOKES, AND K. M. CONWAY. 1991. Three-dimensional computer-assisted analysis of graded contusion lesions in the spinal cord of the rat. J. Neurotrauma 8: 91-101.
17. 17. BRESNAHAN, J. C., M. S. BEATTIE, F. D. TODD III, AND D. H. NOYES. 1987. A behavioral and anatomical analysis of spinal cord injury produced by a feedback-controlled impaction device. Exp. Neurol. 95: 548-570.
18. 18. BRESNAHAN, J. C., J. S. KING, G. F. MARTIN, AND D. YASHON. 1976. A neuroanatomical analysis of spinal cord injury in the rhesus monkey (Macaca mulatta). J. Neurol. Sci. 28: 521-542.
19. 19. CONSTANTINI, S., AND W. YOUNG. 1994. The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats. J. Neurosurg. 80: 97-111.
20. 20. FADEN, A. I., I. SACKSEN, AND L. J. NOBLE. 1988. Opiate-receptor antagonist nalmefene improve neurological recovery after traumatic spinal cord injury in rats through a central mechanism. J. Pharmacol. Exp. Ther. 245: 742-748.
21. 21. FEHLINGS, M. G., AND C. H. TATOR. 1995. The relationship among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury. Exp. Neurol. 132: 220-228.
22. 22. FORD, R. W. J. 1983. A reproducible spinal cord injury model in the cat. J. Neurosurg. 59: 268-275.
23. 23. GALE, K., H. KERASIDIS, AND J. R. WRATHALL. 1985. Spinal cord contusion in the rat: Behavioral analysis of functional neurologic impairment. Exp. Neurol. 88: 123-134.
24. 24. GENTILE, A. M. 1989. Recovery of locomotion following damage of sensorimotor cortex in rats. Pages 66-74 in M. Brown and M. E. Goldberger, Eds., Conference Proceedings: Criteria for Assessing Recovery of Function: Behavioral Methods. American Paralysis Association, Springfield, NJ.
25. 25. GOLDBERGER, M. E. 1988. Spared-root deafferentation of a cat's hindlimb: Hierarchical regulation of pathways mediating recovery of motor behavior. Exp. Brain Res. 73: 329-342.
26. 26. GOLDBERGER, M. E. 1988. Partial and complete deafferentation of cat hindlimb: The contribution of behavioral substitution to recovery of motor function. Exp. Brain Res. 73: 343-353.
27. 27. GOLDBERGER, M. E., E. COLEMAN-PAIGE, AND K. L. ZIEGLER. 1991. Loss of hindlimb stepping after unilateral lumbosacral deafferentation in cats. Soc. Neurosci. Abstr. 17: 1026.
28. 28. GRILLNER, S. 1976. Some aspects of the descending control of the spinal circuits generating locomotor movements. Pages 351-373 in R. M. Herman, S. Grillner, P. S. G. Stein, and D. G. Stuart, Eds., Neural Control of Locomotion. Plenum, New York.
29. 29. GRUNER, J. A. 1992. A monitored contusion model of spinal cord injury in the rat. J. Neurotrauma 9: 123-128.
30. 30. HELGREN, M. E. 1990. Behavioral and Anatomical Studies of the Recovery of Function in the Adult Cat Following Spinal Cord Injury. Dissertation, Medical College of Pennsylvania, Philadelphia.
31. 31. HELGREN, M. E., AND M. E. GOLDBERGER. 1993. The recovery of postural reflexes and locomotion following low thoracic hemisection in the adult cat involves compensation by undamaged primary afferent pathways. Exp. Neurol. 123: 17-34.
32. 32. HOWLAND, D. R., B. S. BREGMAN, A. TESSLER, AND M. E. GOLDBERGER. 1995. Development of locomotor behavior in the spinal kitten. Exp. Neurol. 135: 108-122.
33. 33. HOWLAND, D. R., B. S. BREGMAN, A. TESSLER, AND M. E. GOLDBERGER. 1995. Transplants enhance locomotion in neonatal kittens whose spinal cords are transected. Exp. Neurol. 135: 123-145.
34. 34. KUNKEL-BAGDEN, E., H. N. DAI, AND B. S. BREGMAN. 1992. Recovery of function after spinal cord hemisection in newborn and adult rats: Differential effects on reflex and locomotor function. Exp. Neurol. 116: 40-51.
35. 35. MEANS, E. D., D. K. ANDERSON, T. R. WATERS, AND L. KALAF. 1981. Effect of methylprednisolone in compression trauma to the feline spinal cord. J. Neurosurg. 55: 200-208.
36. 36. NOBLE, L. J., AND J. R. WRATHALL. 1985. Spinal cord contusion in the rat: Morphometric analyses of alterations in the spinal cord. Exp. Neurol. 88: 135-149.
37. 37. NOBLE, L. J., AND J. R. WRATHALL. 1989. Correlative analyses of lesion development and functional status after graded spinal cord contusive injuries in the rat. Exp. Neurol. 103: 34-40.
38. 38. PANJABI, M. M., AND J. R. WRATHALL. 1988. Biomechanical analysis of experimental spinal cord injury and functional loss. Spine 13: 1365-1370.
39. 39. SARUHASHI, Y., AND W. YOUNG. 1994. Effect of mianserin on locomotory function after thoracic spinal cord hemisection in rats. Exp. Neural. 129: 1-10.
40. 40. WRATHALL, J. R., D. CHOINIERE, AND Y. D. TENG. 1994. Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX. J. Neurosci. 14: 6598-6607.
41. 41. WRATHALL, J. R., R. K. PETTEGREW, AND F. HARVEY. 1985. Spinal cord contusion in the rat: Production of graded, reproducible, injury groups. Exp. Neurol. 88: 108-122.