Activin isoforms signal through type I receptor serine/threonine kinase ALK7

Molecular and Cellular Endocrinology

Volumn 220, Issue 1-2, 2004, Pages 59-65

  Tsuchida, Kunihiro ^a   Nakatani, Masashi ^a   Yamakawa, Norio ^a   Hashimoto, Osamu ^b   Hasegawa, Yoshihisa ^b   Sugino, Hiromu ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

Activin isoforms; Activin receptor; ALK7; Insulin; Pancreatic islet

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXY 1 METHYLTETRALIN; ACTIVIN; ACTIVIN A; ACTIVIN AB; ACTIVIN RECEPTOR 1; ACTIVIN RECEPTOR 2; CYTOKINE; LIGAND; MYELOPID; PROTEIN ALK7; PROTEIN SERINE THREONINE KINASE; RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; EMBRYO; HUMAN; HUMAN CELL; INSULIN RELEASE; NEUROSECRETORY CELL; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ACTIVIN RECEPTORS, TYPE I; ACTIVIN RECEPTORS, TYPE II; ACTIVINS; ANIMALS; CELL LINE; HUMANS; INHIBIN-BETA SUBUNITS; INSULIN; ISLETS OF LANGERHANS; MICE; PROTEIN BINDING; PROTEIN ISOFORMS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SOLUBILITY;

EID: 2942527675     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2004.03.009     Document Type: Article

References (24)

1. Aruffo A., Stamenkovic I., Melnick M., Underhill C.B., Seed B. CD44 is the principle cell surface receptor for hyaluronate. Cell. 61:1990;1303-1313
2. Brown C.W., Houston-Hawkins D.E., Woodruff T.K., Matzuk M.M. Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat. Genet. 25:2000;453-457
3. Cameron V.A., Nishimura E., Mathews L.S., Lewis K.A., Sawchenko P.E., Vale W.W. Hybridization histochemical localization of activin receptor subtypes in rat brain, pituitary, ovary, and testis. Endocrinology. 134(2):1994;799-808
4. Corrigan A.Z., Bilezikjian L.M., Carroll R.S., Bald L.N., Schmelzer C.H., Fendly B.M., Mason A.J., Chin W.W., Schwall R.H., Vale W. Evidence for an autocrine role of activin B within rat anterior pituitary cultures. Endocrinology. 128(3):1991;1682-1684
5. Dennler S., Itoh S., Vivien D., tenDijke P., Huet S., Gauthier J.-M. Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17(11):1998;3091-3100
6. Feijen A., Goumans M.J., van den Eijnden-van Raaij A.J. Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins. Development. 120(12):1994;3621-3637
7. Gaddy-Kurten D., Tsuchida K., Vale W. Activins and the receptor serine kinase superfamily. Rec. Prog. Horm. Res. 50:1995;109-129
8. Lau A.L., Kumar T.R., Nishimori K., Bonadio J., Matzuk M.M. Activin betaC and betaE genes are not essential for mouse liver growth, differentiation, and regeneration. Mol. Cell. Biol. 20(16):2000;6127-6137
9. Lorentzon M., Hoffer B., Ebendal T., Olson L., Tomac A. Habrec1, a novel serine/threonine kinase TGF-beta type I-like receptor, has a specific cellular expression suggesting function in the developing organism and adult brain. Exp. Neurol. 142(2):1996;351-360
10. Mathews L.S., Vale W.W. Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell. 65(6):1991;973-982
11. Matzuk M.M., Kumar T.R., Vassalli A., Bickenbach J.R., Roop D.R., Jaenisch R., Bradley A. Functional analysis of activins during mammalian development. Nature. 374(6520):1995;354-356
12. Matzuk M.M. In search of binding - identification of inhibin receptors. Endocrinology. 141(7):2000;2281-2284
13. Nakamura T., Asashima M., Eto Y., Takio K., Uchiyama H., Moriya N., Ariizumi T., Yashiro T., Sugino K., Titani K., Sugino H. Isolation and characterization of native activin B. J. Biol. Chem. 267(23):1992;16385-16389
14. Reissmann E., Jornvall H., Blokzijl A., Andersson O., Chang C., Minchiotti G., Persico M.G., Ibanez C.F., Brivanlou A.H. The orphan receptor ALK7 and the activin receptor ALK4 mediate signaling by nodal proteins during vertebrate development. Genes Dev. 15:2001;2010-2022
15. Roberts V.J., Sawchenko P.E., Vale W. Expression of inhibin/activin subunit messenger ribonucleic acids during rat embryogenesis. Endocrinology. 128(6):1991;3122-3129
16. Ryden M., Imamura T., Jornvall H., Belluardo N., Neveu I., Trupp M., Okadome T., ten Dijke P., Ibanez C.F. A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system. J. Biol. Chem. 271:1996;30603-30609
17. Shimizu A., Kato M., Nakao A., Imamura T., ten Dijke P., Heldin C.H., Kawabata M., Shimada S., Miyazono K. Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line. Genes Cells. 3(2):1998;125-134
18. Sugino, H., Tsuchida, K., 2000. Activin and follistatin. In: Canalis, E. (Ed.), Skeletal Growth Factor. Lippincott Williams & Wilkins, pp. 251-263.
19. Tsuchida K. Activins, myostatin and related TGF-β family members as novel therapeutic targets for endocrine, metabolic and immune disorders. Current Drug Target. 4:2004;159-168
20. Tsuchida K., Sawchenko P.E., Nishikawa S., Vale W.W. Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain. Mol. Cell. Neurosci. 7(6):1996;467-478
21. Tsuchida K., Arai K.Y., Kuramoto Y., Yamakawa N., Hasegawa Y., Sugino H. Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family. J. Biol. Chem. 275(52):2000;40788-40796
22. Vassalli A., Matzuk M.M., Gardner H.A., Lee K.F., Jaenisch R. Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev. 8(4):1994;414-427
23. Watanabe R., Yamada Y., Ihara Y., Someya Y., Kubota A., Kagimoto S., Kuroe A., Iwakura T., Shen Z.P., Inada A., Adachi T., Ban N., Miyawaki K., Sunaga Y., Tsuda K., Seino Y. The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals. Biochem. Biophys. Res. Commun. 254(3):1999;707-712
24. Yamakawa N., Tsuchida K., Sugino H. The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors. EMBO J. 21(7):2002;1684-1694