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Volumn 174, Issue 5, 2016, Pages R175-R187

Mechanisms in endocrinology metabolic and inflammatory pathways on the pathogenesis of type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

COMPLICATION; DIABETES MELLITUS, TYPE 2; HUMAN; IMMUNOLOGY; INFLAMMATION; METABOLISM; OBESITY;

EID: 84969921764     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-15-1065     Document Type: Review
Times cited : (54)

References (163)
  • 1
    • 39749147110 scopus 로고    scopus 로고
    • Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and b-cell failure in type 2 diabetes
    • Muoio DM & Newgard CB. Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and b-cell failure in type 2 diabetes. Nature Reviews. Molecular Cell Biology 2008 9 193-205. (doi:10.1038/nrm2327).
    • (2008) Nature Reviews, Molecular Cell Biology , vol.9 , pp. 193-205
    • Muoio, D.M.1    Newgard, C.B.2
  • 2
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn SE, Hull RL & Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006 444 840-846. (doi:10.1038/nature05482).
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 3
    • 84930185714 scopus 로고    scopus 로고
    • TLR4 at the crossroads of nutrients, gut microbiota, and metabolic inflammation
    • Velloso LA, Folli F & Saad MJ. TLR4 at the crossroads of nutrients, gut microbiota, and metabolic inflammation. Endocrine Reviews 2015 36 245-271. (doi:10.1210/er.2014-1100).
    • (2015) Endocrine Reviews , vol.36 , pp. 245-271
    • Velloso, L.A.1    Folli, F.2    Saad, M.J.3
  • 4
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik DL, Cardozo AK & Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocrine Reviews 2008 29 42-61. (doi:10.1210/er.2007-0015).
    • (2008) Endocrine Reviews , vol.29 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 5
    • 79957563251 scopus 로고    scopus 로고
    • Endocrine disruptors in the etiology of type 2 diabetes mellitus
    • Alonso-Magdalena P, Quesada I& Nadal A. Endocrine disruptors in the etiology of type 2 diabetes mellitus. Nature Reviews. Endocrinology 2011 7 346-353. (doi:10.1038/nrendo.2011.56).
    • (2011) Nature Reviews, Endocrinology , vol.7 , pp. 346-353
    • Alonso-Magdalena, P.1    Quesada, I.2    Nadal, A.3
  • 6
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006 444 860-867. (doi:10.1038/nature05485).
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 7
    • 84888203171 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus - An autoimmune disease? Nature Reviews
    • Velloso LA, Eizirik DL & Cnop M. Type 2 diabetes mellitus - An autoimmune disease? Nature Reviews. Endocrinology 2013 9 750-755. (doi:10.1038/nrendo.2013.131).
    • (2013) Endocrinology , vol.9 , pp. 750-755
    • Velloso, L.A.1    Eizirik, D.L.2    Cnop, M.3
  • 8
    • 84970001481 scopus 로고
    • A fatal case of diabetes mellitus complicated by infection
    • Mills ES. A fatal case of diabetes mellitus complicated by infection. Canadian Medical Association Journal 1924 14 732-734.
    • (1924) Canadian Medical Association Journal , vol.14 , pp. 732-734
    • Mills, E.S.1
  • 9
    • 84969960983 scopus 로고
    • Prophylactic foot treatment in patients with diabetesmellitus: Analyses of its effect on the prevention of infection of the lower extremities and the operative prognosis in a series of five hundred seventy-six cases
    • Brandaleone H, Standard S & Ralli EP. Prophylactic foot treatment in patients with diabetesmellitus: Analyses of its effect on the prevention of infection of the lower extremities and the operative prognosis in a series of five hundred seventy-six cases. Annals of Surgery 1937 105 120-124. (doi:10.1097/00000658-193701000-00011).
    • (1937) Annals of Surgery , vol.105 , pp. 120-124
    • Brandaleone, H.1    Standard, S.2    Ralli, E.P.3
  • 10
    • 69849114897 scopus 로고
    • The nature of the lowered resistance to infection in diabetes mellitus
    • Marble A, White HJ & Fernald AT. The nature of the lowered resistance to infection in diabetes mellitus. Journal of Clinical Investigation 1938 17 423-430. (doi:10.1172/JCI100969).
    • (1938) Journal of Clinical Investigation , vol.17 , pp. 423-430
    • Marble, A.1    White, H.J.2    Fernald, A.T.3
  • 11
    • 84969926083 scopus 로고
    • Immunity in diabetes. III. Relation of tissue glycogen and blood chemistry to bacterial dissemination, antibody formation and survival after infection in diabetes
    • Richardson R. Immunity in diabetes. III. Relation of tissue glycogen and blood chemistry to bacterial dissemination, antibody formation and survival after infection in diabetes. Journal of Clinical Investigation 1940 19 239-250. (doi:10.1172/JCI101116).
    • (1940) Journal of Clinical Investigation , vol.19 , pp. 239-250
    • Richardson, R.1
  • 12
    • 0010515683 scopus 로고
    • Transmetatarsal amputation for infection or gangrene in patients with diabetes mellitus
    • McKittrick LS, McKittrick JB & Risley TS. Transmetatarsal amputation for infection or gangrene in patients with diabetes mellitus. Annals of Surgery 1949 130 826-840. (doi:10.1097/00000658-194910000-00019).
    • (1949) Annals of Surgery , vol.130 , pp. 826-840
    • McKittrick, L.S.1    McKittrick, J.B.2    Risley, T.S.3
  • 13
    • 81355157520 scopus 로고
    • Insulin deficiency and insulin inefficiency
    • Himsworth HP. Insulin deficiency and insulin inefficiency. British Medical Journal 1940 1 719-722. (doi:10.1136/bmj.1.4139.719).
    • (1940) British Medical Journal , vol.1 , pp. 719-722
    • Himsworth, H.P.1
  • 14
    • 84967934179 scopus 로고
    • Insulin resistance and sensitivity
    • Insulin resistance and sensitivity. British Medical Journal 1940 1 734. (doi:10.1136/bmj.1.4139.734).
    • (1940) British Medical Journal , vol.1 , pp. 734
  • 15
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-a: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS & Spiegelman BM. Adipose expression of tumor necrosis factor-a: direct role in obesity-linked insulin resistance. Science 1993 259 87-91. (doi:10.1126/science.7678183).
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 16
    • 79953046341 scopus 로고    scopus 로고
    • Inflammatory mechanisms in obesity
    • Gregor MF & Hotamisligil GS. Inflammatory mechanisms in obesity. Annual Review of Immunology 2011 29 415-445. (doi:10.1146/annurevimmunol- 031210-101322).
    • (2011) Annual Review of Immunology , vol.29 , pp. 415-445
    • Gregor, M.F.1    Hotamisligil, G.S.2
  • 18
    • 73949126369 scopus 로고    scopus 로고
    • Islet inflammation impairs the pancreatic b-cell in type 2 diabetes
    • Donath MY, Boni-Schnetzler M, Ellingsgaard H & Ehses JA. Islet inflammation impairs the pancreatic b-cell in type 2 diabetes. Physiology 2009 24 325-331. (doi:10.1152/physiol.00032.2009).
    • (2009) Physiology , vol.24 , pp. 325-331
    • Donath, M.Y.1    Boni-Schnetzler, M.2    Ellingsgaard, H.3    Ehses, J.A.4
  • 22
    • 79952451443 scopus 로고    scopus 로고
    • Obesity, insulin resistance and free fatty acids
    • Boden G. Obesity, insulin resistance and free fatty acids. Current Opinion in Endocrinology, Diabetes and Obesity 2011 18 139-143. (doi:10.1097/MED.0b013e3283444b09).
    • (2011) Current Opinion in Endocrinology, Diabetes and Obesity , vol.18 , pp. 139-143
    • Boden, G.1
  • 23
    • 0029049346 scopus 로고
    • A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM
    • Paolisso G, Tataranni PA, Foley JE, Bogardus C, Howard BV & Ravussin E. A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia 1995 38 1213-1217. (doi:10.1007/BF00422371).
    • (1995) Diabetologia , vol.38 , pp. 1213-1217
    • Paolisso, G.1    Tataranni, P.A.2    Foley, J.E.3    Bogardus, C.4    Howard, B.V.5    Ravussin, E.6
  • 24
    • 7044269441 scopus 로고    scopus 로고
    • Free fatty acid levels modulate microvascular function: Relevance for obesity-associated insulin resistance, hypertension, and microangiopathy
    • deJongh RT, Serne EH, Ijzerman RG, deVries G & Stehouwer CD. Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy. Diabetes 2004 53 2873-2882. (doi:10.2337/diabetes.53.11.2873).
    • (2004) Diabetes , vol.53 , pp. 2873-2882
    • De Jongh, R.T.1    Serne, E.H.2    Ijzerman, R.G.3    De Vries, G.4    Stehouwer, C.D.5
  • 26
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C q and alterations in the insulin signaling cascade
    • Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF & Shulman GI. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C q and alterations in the insulin signaling cascade. Diabetes 1999 48 1270-1274. (doi:10.2337/diabetes.48.6.1270).
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3    Bell, K.4    Barucci, N.5    Lee, D.6    Goodyear, L.J.7    Kraegen, E.W.8    White, M.F.9    Shulman, G.I.10
  • 27
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010 140 900-917. (doi:10.1016/j.cell. 2010.02.034).
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 28
    • 84860497397 scopus 로고    scopus 로고
    • Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance
    • Jornayvaz FR & Shulman GI. Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance. Cell Metabolism 2012 15 574-584. (doi:10.1016/j.cmet.2012.03.005).
    • (2012) Cell Metabolism , vol.15 , pp. 574-584
    • Jornayvaz, F.R.1    Shulman, G.I.2
  • 29
    • 75749108288 scopus 로고    scopus 로고
    • Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
    • Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ & Hotamisligil GS. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 2010 140 338-348. (doi:10.1016/j.cell.2010.01.001).
    • (2010) Cell , vol.140 , pp. 338-348
    • Nakamura, T.1    Furuhashi, M.2    Li, P.3    Cao, H.4    Tuncman, G.5    Sonenberg, N.6    Gorgun, C.Z.7    Hotamisligil, G.S.8
  • 30
    • 84897129156 scopus 로고    scopus 로고
    • Differential scales of protein quality control
    • Wolff S, Weissman JS & Dillin A. Differential scales of protein quality control. Cell 2014 157 52-64. (doi:10.1016/j.cell.2014.03.007).
    • (2014) Cell , vol.157 , pp. 52-64
    • Wolff, S.1    Weissman, J.S.2    Dillin, A.3
  • 31
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response. Nature Review
    • Ron D & Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nature Review. Molecular and Cellular Biology 2007 8 519-529. (doi:10.1038/nrm2199).
    • (2007) Molecular and Cellular Biology , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 32
    • 84880641508 scopus 로고    scopus 로고
    • Evolution of the unfolded protein response
    • Hollien J. Evolution of the unfolded protein response. Biochimica et Biophysica Acta 2013 1833 2458-2463. (doi:10.1016/j.bbamcr.2013. 01.016).
    • (2013) Biochimica et Biophysica Acta , vol.1833 , pp. 2458-2463
    • Hollien, J.1
  • 33
    • 58149484392 scopus 로고    scopus 로고
    • Inflammation and endoplasmic reticulum stress in obesity and diabetes
    • Hotamisligil GS. Inflammation and endoplasmic reticulum stress in obesity and diabetes. International Journal of Obesity 2008 32 (Suppl 7) S52-S54. (doi:10.1038/ijo.2008.238).
    • (2008) International Journal of Obesity , vol.32 , pp. S52-S54
    • Hotamisligil, G.S.1
  • 35
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ & Hotamisligil GS. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006 313 1137-1140. (doi:10.1126/science.1128294).
    • (2006) Science , vol.313 , pp. 1137-1140
    • Ozcan, U.1    Yilmaz, E.2    Ozcan, L.3    Furuhashi, M.4    Vaillancourt, E.5    Smith, R.O.6    Gorgun, C.Z.7    Hotamisligil, G.S.8
  • 36
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKK b/NF-kB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang X, Zhang G, Zhang H, Karin M, Bai H & Cai D. Hypothalamic IKK b/NF-kB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008 135 61-73. (doi:10.1016/j.cell.2008.07.043).
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 37
    • 57849115277 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress plays a central role in development of leptin resistance
    • Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, Myers MG Jr & Ozcan U. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metabolism 2009 9 35-51. (doi:10.1016/j.cmet.2008.12.004).
    • (2009) Cell Metabolism , vol.9 , pp. 35-51
    • Ozcan, L.1    Ergin, A.S.2    Lu, A.3    Chung, J.4    Sarkar, S.5    Nie, D.6    Myers, M.G.7    Ozcan, U.8
  • 38
    • 58849149821 scopus 로고    scopus 로고
    • Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity
    • Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, Tsukumo DM, Anhe G, Amaral ME, Takahashi HK et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. Journal of Neuroscience 2009 29 359-370. (doi:10.1523/JNEUROSCI.2760-08.2009).
    • (2009) Journal of Neuroscience , vol.29 , pp. 359-370
    • Milanski, M.1    Degasperi, G.2    Coope, A.3    Morari, J.4    Denis, R.5    Cintra, D.E.6    Tsukumo, D.M.7    Anhe, G.8    Amaral, M.E.9    Takahashi, H.K.10
  • 39
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O & Akira S. Pattern recognition receptors and inflammation. Cell 2010 140 805-820. (doi:10.1016/j.cell.2010.01.022).
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 40
    • 61849170035 scopus 로고    scopus 로고
    • TLRs and innate immunity
    • Beutler BA. TLRs and Innate Immunity. Blood 2009 113 1399-1407. (doi:10.1182/blood-2008-07-019307).
    • (2009) Blood , vol.113 , pp. 1399-1407
    • Beutler, B.A.1
  • 42
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • Lee JY, Sohn KH, Rhee SH & Hwang D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. Journal of Biological Chemistry 2001 276 16683-16689. (doi:10.1074/jbc.M011695200).
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 43
    • 58149310977 scopus 로고    scopus 로고
    • Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kB pathway in adipocytes links nutritional signalling with innate immunity
    • Schaeffler A, Gross P, Buettner R, Bollheimer C, Buechler C, Neumeier M, Kopp A, Schoelmerich J & Falk W. Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kB pathway in adipocytes links nutritional signalling with innate immunity. Immunology 2009 126 233-245. (doi:10.1111/j.1365-2567.2008. 02892.x).
    • (2009) Immunology , vol.126 , pp. 233-245
    • Schaeffler, A.1    Gross, P.2    Buettner, R.3    Bollheimer, C.4    Buechler, C.5    Neumeier, M.6    Kopp, A.7    Schoelmerich, J.8    Falk, W.9
  • 44
    • 33745187112 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
    • Song MJ, Kim KH, Yoon JM & Kim JB. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochemical and Biophysical Research Communications 2006 346 739-745. (doi:10.1016/j.bbrc.2006.05.170).
    • (2006) Biochemical and Biophysical Research Communications , vol.346 , pp. 739-745
    • Song, M.J.1    Kim, K.H.2    Yoon, J.M.3    Kim, J.B.4
  • 48
    • 84919725442 scopus 로고    scopus 로고
    • TLR4 expression in bone marrow-derived cells is both necessary and sufficient to produce the insulin resistance phenotype in diet-induced obesity
    • Razolli DS, Moraes JC, Morari J, Moura RF, Vinolo MA & Velloso LA. TLR4 expression in bone marrow-derived cells is both necessary and sufficient to produce the insulin resistance phenotype in diet-induced obesity. Endocrinology 2015 156 103-113. (doi:10.1210/en.2014-1552).
    • (2015) Endocrinology , vol.156 , pp. 103-113
    • Razolli, D.S.1    Moraes, J.C.2    Morari, J.3    Moura, R.F.4    Vinolo, M.A.5    Velloso, L.A.6
  • 49
    • 70350389389 scopus 로고    scopus 로고
    • Hematopoietic cell-specific deletion of tolllike receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
    • Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, Bandyopadhyay G, Verma IM & Olefsky JM. Hematopoietic cell-specific deletion of tolllike receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metabolism 2009 10 419-429. (doi:10.1016/j.cmet.2009.09.006).
    • (2009) Cell Metabolism , vol.10 , pp. 419-429
    • Saberi, M.1    Woods, N.B.2    De Luca, C.3    Schenk, S.4    Lu, J.C.5    Bandyopadhyay, G.6    Verma, I.M.7    Olefsky, J.M.8
  • 51
    • 51349156218 scopus 로고    scopus 로고
    • Insulin sensitivity: Modulation by nutrients and inflammation
    • Schenk S, Saberi M & Olefsky JM. Insulin sensitivity: modulation by nutrients and inflammation. Journal of Clinical Investigation 2008 118 2992-3002. (doi:10.1172/JCI34260).
    • (2008) Journal of Clinical Investigation , vol.118 , pp. 2992-3002
    • Schenk, S.1    Saberi, M.2    Olefsky, J.M.3
  • 52
    • 73949110679 scopus 로고    scopus 로고
    • Saturated fatty acids do not directly stimulate Toll-like receptor signaling
    • Erridge C & Samani NJ. Saturated fatty acids do not directly stimulate Toll-like receptor signaling. Arteriosclerosis, Thrombosis, and Vascular Biology 2009 29 1944-1949. (doi:10.1161/ATVBAHA.109.194050).
    • (2009) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.29 , pp. 1944-1949
    • Erridge, C.1    Samani, N.J.2
  • 56
    • 84878433548 scopus 로고    scopus 로고
    • Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans
    • Stefan N & Haring HU. Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans. Nature Medicine 2013 19 394-395. (doi:10.1038/nm.3116).
    • (2013) Nature Medicine , vol.19 , pp. 394-395
    • Stefan, N.1    Haring, H.U.2
  • 57
    • 84872012316 scopus 로고    scopus 로고
    • Plasma levels of fetuin-A and hepatic enzymes and risk of type 2 diabetes in women in the U.S.
    • Sun Q, Cornelis MC, Manson JE & Hu FB. Plasma levels of fetuin-A and hepatic enzymes and risk of type 2 diabetes in women in the U.S. Diabetes 2013 62 49-55. (doi:10.2337/db12-0372).
    • (2013) Diabetes , vol.62 , pp. 49-55
    • Sun, Q.1    Cornelis, M.C.2    Manson, J.E.3    Hu, F.B.4
  • 60
    • 72249106180 scopus 로고    scopus 로고
    • Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a highfat, high-carbohydrate meal: Implications for insulin resistance
    • Ghanim H, Abuaysheh S, Sia CL, Korzeniewski K, Chaudhuri A, Fernandez-Real JM & Dandona P. Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a highfat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care 2009 32 2281-2287. (doi:10.2337/dc09-0979).
    • (2009) Diabetes Care , vol.32 , pp. 2281-2287
    • Ghanim, H.1    Abuaysheh, S.2    Sia, C.L.3    Korzeniewski, K.4    Chaudhuri, A.5    Fernandez-Real, J.M.6    Dandona, P.7
  • 63
    • 84863870958 scopus 로고    scopus 로고
    • Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity
    • Cani PD, Osto M, Geurts L & Everard A. Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity. Gut Microbes 2012 3 279-288. (doi:10.4161/gmic.19625).
    • (2012) Gut Microbes , vol.3 , pp. 279-288
    • Cani, P.D.1    Osto, M.2    Geurts, L.3    Everard, A.4
  • 64
    • 84891524250 scopus 로고    scopus 로고
    • Assessing the human gut microbiota in metabolic diseases
    • Karlsson F, Tremaroli V, Nielsen J & Backhed F. Assessing the human gut microbiota in metabolic diseases. Diabetes 2013 62 3341-3349. (doi:10.2337/db13-0844).
    • (2013) Diabetes , vol.62 , pp. 3341-3349
    • Karlsson, F.1    Tremaroli, V.2    Nielsen, J.3    Backhed, F.4
  • 68
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER & Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006 444 1027-1031. (doi:10.1038/nature05414).
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 70
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia- induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM & Burcelin R. Changes in gut microbiota control metabolic endotoxemia- induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008 57 1470-1481. (doi:10.2337/db07-1403).
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3    Waget, A.4    Neyrinck, A.M.5    Delzenne, N.M.6    Burcelin, R.7
  • 71
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkB-a
    • Itani SI, Ruderman NB, Schmieder F & Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkB-a. Diabetes 2002 51 2005-2011. (doi:10.2337/diabetes.51.7.2005).
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 73
    • 85047681823 scopus 로고    scopus 로고
    • Protein kinase Cq expression is increased upon differentiation of human skeletal muscle cells: Dysregulation in type 2 diabetic patients and a possible role for protein kinase Cq in insulin-stimulated glycogen synthase activity
    • Chalfant CE, Ciaraldi TP, Watson JE, Nikoulina S, Henry RR & Cooper DR. Protein kinase Cq expression is increased upon differentiation of human skeletal muscle cells: dysregulation in type 2 diabetic patients and a possible role for protein kinase Cq in insulin-stimulated glycogen synthase activity. Endocrinology 2000 141 2773-2778. (doi:10.1210/endo.141.8.7591).
    • (2000) Endocrinology , vol.141 , pp. 2773-2778
    • Chalfant, C.E.1    Ciaraldi, T.P.2    Watson, J.E.3    Nikoulina, S.4    Henry, R.R.5    Cooper, D.R.6
  • 74
    • 18044382930 scopus 로고    scopus 로고
    • Atypical protein kinase C in insulin action and insulin resistance
    • Farese RV, Sajan MP & Standaert ML. Atypical protein kinase C in insulin action and insulin resistance. Biochemical Society Transactions 2005 33 350-353. (doi:10.1042/BST0330350).
    • (2005) Biochemical Society Transactions , vol.33 , pp. 350-353
    • Farese, R.V.1    Sajan, M.P.2    Standaert, M.L.3
  • 75
    • 0019222257 scopus 로고
    • Characterization of doublestranded- RNA-activated kinase that phosphorylates a subunit of eukaryotic initiation factor 2 (eIF-2 a) in reticulocyte lysates
    • Levin DH, Petryshyn R & London IM. Characterization of doublestranded- RNA-activated kinase that phosphorylates a subunit of eukaryotic initiation factor 2 (eIF-2 a) in reticulocyte lysates. PNAS 1980 77 832-836. (doi:10.1073/pnas.77.2.832).
    • (1980) PNAS , vol.77 , pp. 832-836
    • Levin, D.H.1    Petryshyn, R.2    London, I.M.3
  • 78
    • 84893155439 scopus 로고    scopus 로고
    • Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice
    • hashi M & Hotamisligil GS. Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. Diabetes 2014 63 526-534. (doi:10.2337/db13-1019).
    • (2014) Diabetes , vol.63 , pp. 526-534
    • Hashi, M.1    Hotamisligil, G.S.2
  • 79
    • 84893154243 scopus 로고    scopus 로고
    • Turning off a viral/lipid sensor improves type 2 diabetes
    • Velloso LA. Turning off a viral/lipid sensor improves type 2 diabetes. Diabetes 2014 63 393-395. (doi:10.2337/db13-1704).
    • (2014) Diabetes , vol.63 , pp. 393-395
    • Velloso, L.A.1
  • 80
    • 77956185248 scopus 로고    scopus 로고
    • CJun NH2-terminal kinase 1 (JNK1): Roles in metabolic regulation of insulin resistance
    • Sabio G & Davis RJ. cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends in Biochemical Science 2010 35 490-496. (doi:10.1016/j.tibs.2010.04.004).
    • (2010) Trends in Biochemical Science , vol.35 , pp. 490-496
    • Sabio, G.1    Davis, R.J.2
  • 81
    • 80053910309 scopus 로고    scopus 로고
    • JNKs, insulin resistance and inflammation: A possible link between NAFLD and coronary artery disease
    • Tarantino G & Caputi A. JNKs, insulin resistance and inflammation: A possible link between NAFLD and coronary artery disease. World Journal of Gastroenterology 2011 17 3785-3794. (doi:10.3748/wjg.v17.i33.3785).
    • (2011) World Journal of Gastroenterology , vol.17 , pp. 3785-3794
    • Tarantino, G.1    Caputi, A.2
  • 82
    • 84944313564 scopus 로고    scopus 로고
    • Stress kinases in the modulation of metabolism and energy balance
    • Manieri E & Sabio G. Stress kinases in the modulation of metabolism and energy balance. Journal of Molecular Endocrinology 2015 55 R11-R22. (doi:10.1530/JME-15-0146).
    • (2015) Journal of Molecular Endocrinology , vol.55 , pp. R11-R22
    • Manieri, E.1    Sabio, G.2
  • 83
    • 0029847504 scopus 로고    scopus 로고
    • Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
    • Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE & Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 1996 274 1377-1379. (doi:10.1126/science. 274.5291.1377).
    • (1996) Science , vol.274 , pp. 1377-1379
    • Hotamisligil, G.S.1    Johnson, R.S.2    Distel, R.J.3    Ellis, R.4    Papaioannou, V.E.5    Spiegelman, B.M.6
  • 86
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP & Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000 287 664-666. (doi:10.1126/science.287.5453.664).
    • (2000) Science , vol.287 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5    Harding, H.P.6    Ron, D.7
  • 89
    • 78650878363 scopus 로고    scopus 로고
    • NF-kB, inflammation, and metabolic disease
    • Baker RG, Hayden MS & Ghosh S. NF-kB, inflammation, and metabolic disease. Cell Metabolism 2011 13 11-22. (doi:10.1016/j.cmet.2010.12.008).
    • (2011) Cell Metabolism , vol.13 , pp. 11-22
    • Baker, R.G.1    Hayden, M.S.2    Ghosh, S.3
  • 90
    • 77957252647 scopus 로고    scopus 로고
    • The IKK, complex, a central regulator of NF-kB activation
    • Israel A. The IKK, complex, a central regulator of NF-kB activation. Cold Spring Harbor Perspectives in Biology 2010 2 a000158. (doi:10.1101/cshperspect.a000158).
    • (2010) Cold Spring Harbor Perspectives in Biology , vol.2 , pp. a000158
    • Israel, A.1
  • 91
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kB signaling
    • HaydenMS & Ghosh S. Shared principles in NF-kB signaling. Cell 2008 132 344-362. (doi:10.1016/j.cell.2008.01.020).
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 92
    • 56749164791 scopus 로고    scopus 로고
    • Nutrient sensing and inflammation in metabolic diseases
    • Hotamisligil GS & Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nature Reviews Immunology 2008 8 923-934. (doi:10.1038/nri2449).
    • (2008) Nature Reviews Immunology , vol.8 , pp. 923-934
    • Hotamisligil, G.S.1    Erbay, E.2
  • 93
    • 34250823515 scopus 로고    scopus 로고
    • Gene-specific control of inflammation by TLR-induced chromatin modifications
    • Foster SL, Hargreaves DC & Medzhitov R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 2007 447 972-978. (doi:10.1038/nature05836).
    • (2007) Nature , vol.447 , pp. 972-978
    • Foster, S.L.1    Hargreaves, D.C.2    Medzhitov, R.3
  • 94
    • 84884562282 scopus 로고    scopus 로고
    • Epigenetic signatures and vascular risk in type 2 diabetes: A clinical perspective
    • Paneni F, Costantino S, Volpe M, Luscher TF & Cosentino F. Epigenetic signatures and vascular risk in type 2 diabetes: A clinical perspective. Atherosclerosis 2013 230 191-197. (doi:10.1016/j.atherosclerosis.2013.07.003).
    • (2013) Atherosclerosis , vol.230 , pp. 191-197
    • Paneni, F.1    Costantino, S.2    Volpe, M.3    Luscher, T.F.4    Cosentino, F.5
  • 96
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-b and NF-kB
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J & Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-b and NF-kB. Nature Medicine 2005 11 183-190. (doi:10.1038/nm1166).
    • (2005) Nature Medicine , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 97
    • 80755152884 scopus 로고    scopus 로고
    • Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-kB stress pathway
    • Le KA, Mahurkar S, Alderete TL, Hasson RE, Adam TC, Kim JS, Beale E, Xie C, Greenberg AS, Allayee H et al. Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-kB stress pathway. Diabetes 2011 60 2802-2809. (doi:10.2337/db10-1263).
    • (2011) Diabetes , vol.60 , pp. 2802-2809
    • Le, K.A.1    Mahurkar, S.2    Alderete, T.L.3    Hasson, R.E.4    Adam, T.C.5    Kim, J.S.6    Beale, E.7    Xie, C.8    Greenberg, A.S.9    Allayee, H.10
  • 98
    • 84903534630 scopus 로고    scopus 로고
    • Effect of salsalate on insulin action, secretion, and clearance in nondiabetic, insulin-resistant individuals: A randomized, placebo-controlled study
    • Kim SH, Liu A, Ariel D, Abbasi F, Lamendola C, Grove K, Tomasso V, Ochoa H & Reaven G. Effect of salsalate on insulin action, secretion, and clearance in nondiabetic, insulin-resistant individuals: A randomized, placebo-controlled study. Diabetes Care 2014 37 1944-1950. (doi:10.2337/dc13-2977).
    • (2014) Diabetes Care , vol.37 , pp. 1944-1950
    • Kim, S.H.1    Liu, A.2    Ariel, D.3    Abbasi, F.4    Lamendola, C.5    Grove, K.6    Tomasso, V.7    Ochoa, H.8    Reaven, G.9
  • 99
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T & Hall MN. TOR, a central controller of cell growth. Cell 2000 103 253-262. (doi:10.1016/S0092-8674(00)00117-3).
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 100
    • 84894486696 scopus 로고    scopus 로고
    • Nutrient regulation of the mTOR complex 1 signaling pathway
    • Kim SG, Buel GR & Blenis J. Nutrient regulation of the mTOR complex 1 signaling pathway. Molecules and Cells 2013 35 463-473. (doi:10.1007/s10059-013-0138-2).
    • (2013) Molecules and Cells , vol.35 , pp. 463-473
    • Kim, S.G.1    Buel, G.R.2    Blenis, J.3
  • 101
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control, nature review
    • Ma XM & Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nature Review. Molecular and Cellular Biology 2009 10 307-318. (doi:10.1038/nrm2672).
    • (2009) Molecular and Cellular Biology , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 102
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante M & Sabatini DM. mTOR signaling in growth control and disease. Cell 2012 149 274-293. (doi:10.1016/j.cell.2012.03.017).
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 103
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing. Nature Review
    • Zoncu R, Efeyan A & Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nature Review. Molecular and Cellular Biology 2011 12 21-35. (doi:10.1038/nrm3025).
    • (2011) Molecular and Cellular Biology , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 104
    • 38149083478 scopus 로고    scopus 로고
    • Regulation of interleukin-6- induced hepatic insulin resistance bymammalian target of rapamycin through the STAT3-SOCS3 pathway
    • Kim JH, Kim JE, Liu HY, CaoW& Chen J. Regulation of interleukin-6- induced hepatic insulin resistance bymammalian target of rapamycin through the STAT3-SOCS3 pathway. Journal of Biological Chemistry 2008 283 708-715. (doi:10.1074/jbc.M708568200).
    • (2008) Journal of Biological Chemistry , vol.283 , pp. 708-715
    • Kim, J.H.1    Kim, J.E.2    Liu, H.Y.3    Cao, W.4    Chen, J.5
  • 105
    • 84919965563 scopus 로고    scopus 로고
    • Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice
    • Jiang H, Westerterp M, Wang C, Zhu Y & Ai D. Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice. Diabetologia 2014 57 2393-2404. (doi:10.1007/s00125-014-3350-5).
    • (2014) Diabetologia , vol.57 , pp. 2393-2404
    • Jiang, H.1    Westerterp, M.2    Wang, C.3    Zhu, Y.4    Ai, D.5
  • 106
    • 0037424466 scopus 로고    scopus 로고
    • Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation
    • Greene MW, Sakaue H, Wang L, Alessi DR & Roth RA. Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation. Journal of Biological Chemistry 2003 278 8199-8211. (doi:10.1074/jbc.M209153200).
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 8199-8211
    • Greene, M.W.1    Sakaue, H.2    Wang, L.3    Alessi, D.R.4    Roth, R.A.5
  • 107
    • 8444224619 scopus 로고    scopus 로고
    • Balancing Akt with S6K: Implications for bothmetabolic diseases and tumorigenesis
    • Manning BD. Balancing Akt with S6K: implications for bothmetabolic diseases and tumorigenesis. Journal of Cell Biology 2004 167 399-403. (doi:10.1083/jcb.200408161).
    • (2004) Journal of Cell Biology , vol.167 , pp. 399-403
    • Manning, B.D.1
  • 108
    • 37349006913 scopus 로고    scopus 로고
    • TNF-a and adipocyte biology
    • Cawthorn WP & Sethi JK. TNF-a and adipocyte biology. FASEB Letters 2008 582 117-131. (doi:10.1016/j.febslet.2007.11.051).
    • (2008) FASEB Letters , vol.582 , pp. 117-131
    • Cawthorn, W.P.1    Sethi, J.K.2
  • 110
    • 77954232611 scopus 로고    scopus 로고
    • Transmembrane TNF-a: Structure, function and interaction with anti- TNF agents
    • Horiuchi T, Mitoma H, Harashima S, Tsukamoto H & Shimoda T. Transmembrane TNF-a: structure, function and interaction with anti- TNF agents. Rheumatology 2010 49 1215-1228. (doi:10.1093/rheumatology/keq031).
    • (2010) Rheumatology , vol.49 , pp. 1215-1228
    • Horiuchi, T.1    Mitoma, H.2    Harashima, S.3    Tsukamoto, H.4    Shimoda, T.5
  • 112
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-a function
    • Uysal KT, Wiesbrock SM, Marino MW & Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-a function. Nature 1997 389 610-614. (doi:10.1038/39335).
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 114
    • 0028031569 scopus 로고
    • Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes, Central role of tumor necrosis factor-a
    • Hotamisligil GS, Budavari A, Murray D & Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-a. Journal of Clinical Investigation 1994 94 1543-1549. (doi:10.1172/JCI117495).
    • (1994) Journal of Clinical Investigation , vol.94 , pp. 1543-1549
    • Hotamisligil, G.S.1    Budavari, A.2    Murray, D.3    Spiegelman, B.M.4
  • 116
    • 78650917112 scopus 로고    scopus 로고
    • TNF-a antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome
    • Stanley TL, Zanni MV, Johnsen S, Rasheed S, Makimura H, Lee H, Khor VK, Ahima RS & Grinspoon SK. TNF-a antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome. Journal of Clinical Endocrinology and Metabolism 2011 96 E146-E150. (doi:10.1210/jc.2010-1170).
    • (2011) Journal of Clinical Endocrinology and Metabolism , vol.96 , pp. E146-E150
    • Stanley, T.L.1    Zanni, M.V.2    Johnsen, S.3    Rasheed, S.4    Makimura, H.5    Lee, H.6    Khor, V.K.7    Ahima, R.S.8    Grinspoon, S.K.9
  • 117
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annual Review of Immunology 2009 27 519-550. (doi:10.1146/annurev.immunol.021908.132612).
    • (2009) Annual Review of Immunology , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 118
    • 84855989829 scopus 로고    scopus 로고
    • Inflammasomes in healthanddisease
    • Strowig T, Henao-Mejia J, Elinav E & Flavell R. Inflammasomes in healthanddisease. Nature 2012 481 278-286. (doi:10.1038/nature10759).
    • (2012) Nature , vol.481 , pp. 278-286
    • Strowig, T.1    Henao-Mejia, J.2    Elinav, E.3    Flavell, R.4
  • 119
  • 123
    • 79959438318 scopus 로고    scopus 로고
    • Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis
    • McGillicuddy FC, Harford KA, Reynolds CM, Oliver E, Claessens M, Mills KH & Roche HM. Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis. Diabetes 2011 60 1688-1698. (doi:10.2337/db10-1278).
    • (2011) Diabetes , vol.60 , pp. 1688-1698
    • McGillicuddy, F.C.1    Harford, K.A.2    Reynolds, C.M.3    Oliver, E.4    Claessens, M.5    Mills, K.H.6    Roche, H.M.7
  • 125
    • 84939773528 scopus 로고    scopus 로고
    • IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance
    • Ballak DB, Stienstra R, Tack CJ, Dinarello CA & vanDiepen JA. IL-1 family members in the pathogenesis and treatment of metabolic disease: focus on adipose tissue inflammation and insulin resistance. Cytokine 2015 75 280-290. (doi:10.1016/j.cyto.2015.05.005).
    • (2015) Cytokine , vol.75 , pp. 280-290
    • Ballak, D.B.1    Stienstra, R.2    Tack, C.J.3    Dinarello, C.A.4    Van Diepen, J.A.5
  • 126
    • 84878774925 scopus 로고    scopus 로고
    • Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1b antibody, in patients with type 2 diabetes
    • Sloan-Lancaster J, Abu-Raddad E, Polzer J, Miller JW, Scherer JC, De Gaetano A, Berg JK & Landschulz WH. Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1b antibody, in patients with type 2 diabetes. Diabetes Care 2013 36 2239-2246. (doi:10.2337/dc12-1835).
    • (2013) Diabetes Care , vol.36 , pp. 2239-2246
    • Sloan-Lancaster, J.1    Abu-Raddad, E.2    Polzer, J.3    Miller, J.W.4    Scherer, J.C.5    De Gaetano, A.6    Berg, J.K.7    Landschulz, W.H.8
  • 127
    • 84870619337 scopus 로고    scopus 로고
    • Effects of interleukin-1b inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: A phase IIb randomized, placebo-controlled trial
    • Ridker PM, Howard CP, Walter V, Everett B, Libby P, Hensen J & Thuren T. Effects of interleukin-1b inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: A phase IIb randomized, placebo-controlled trial. Circulation 2012 126 2739-2748. (doi:10.1161/CIRCULATIONAHA.112.122556).
    • (2012) Circulation , vol.126 , pp. 2739-2748
    • Ridker, P.M.1    Howard, C.P.2    Walter, V.3    Everett, B.4    Libby, P.5    Hensen, J.6    Thuren, T.7
  • 129
    • 84920285641 scopus 로고    scopus 로고
    • IL-6 biology: Implications for clinical targeting in rheumatic disease. Nature Reviews
    • Calabrese LH & Rose-John S. IL-6 biology: implications for clinical targeting in rheumatic disease. Nature Reviews. Rheumatology 2014 10 720-727. (doi:10.1038/nrrheum.2014.127).
    • (2014) Rheumatology , vol.10 , pp. 720-727
    • Calabrese, L.H.1    Rose-John, S.2
  • 130
    • 84904617950 scopus 로고    scopus 로고
    • The biology and medical implications of interleukin-6
    • Tanaka T & Kishimoto T. The biology and medical implications of interleukin-6. Cancer Immunology Research 2014 2 288-294. (doi:10.1158/2326-6066.CIR-14-0022).
    • (2014) Cancer Immunology Research , vol.2 , pp. 288-294
    • Tanaka, T.1    Kishimoto, T.2
  • 131
    • 81555209757 scopus 로고    scopus 로고
    • The many faces of interleukin-6: The role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis
    • Barnes TC, AndersonME & Moots RJ. The many faces of interleukin-6: The role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis. International Journal of Rheumatology 2011 2011 721608. (doi:10.1155/2011/721608).
    • (2011) International Journal of Rheumatology, 2011 , pp. 721608
    • Barnes, T.C.1    Anderson, M.E.2    Moots, R.J.3
  • 132
  • 133
    • 23044468612 scopus 로고    scopus 로고
    • Interleukin-6 depletion selectively improves hepatic insulin action in obesity
    • Klover PJ, Clementi AH & Mooney RA. Interleukin-6 depletion selectively improves hepatic insulin action in obesity. Endocrinology 2005 146 3417-3427. (doi:10.1210/en.2004-1468).
    • (2005) Endocrinology , vol.146 , pp. 3417-3427
    • Klover, P.J.1    Clementi, A.H.2    Mooney, R.A.3
  • 134
  • 135
    • 0031762908 scopus 로고    scopus 로고
    • Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid
    • Fried SK, Bunkin DA & Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. Journal of Clinical Endocrinology and Metabolism 1998 83 847-850. (doi:10.1210/jcem.83.3.4660).
    • (1998) Journal of Clinical Endocrinology and Metabolism , vol.83 , pp. 847-850
    • Fried, S.K.1    Bunkin, D.A.2    Greenberg, A.S.3
  • 136
    • 0242580711 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-a, overexpressed in human fat cells from insulin-resistant subjects
    • Rotter V, Nagaev I & Smith U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-a, overexpressed in human fat cells from insulin-resistant subjects. Journal of Biological Chemistry 2003 278 45777-45784. (doi:10.1074/jbc.M301977200).
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 45777-45784
    • Rotter, V.1    Nagaev, I.2    Smith, U.3
  • 137
    • 84874428240 scopus 로고    scopus 로고
    • Adipokine inflammation and insulin resistance: The role of glucose, lipids and endotoxin
    • Piya MK, McTernan PG & Kumar S. Adipokine inflammation and insulin resistance: The role of glucose, lipids and endotoxin. Journal of Endocrinology 2013 216 T1-T15. (doi:10.1530/JOE-12-0498).
    • (2013) Journal of Endocrinology , vol.216 , pp. T1-T15
    • Piya, M.K.1    McTernan, P.G.2    Kumar, S.3
  • 142
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder K & Tschopp J. The inflammasomes. Cell 2010 140 821-832. (doi:10.1016/j.cell.2010.01.040).
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 144
    • 80052650475 scopus 로고    scopus 로고
    • IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction
    • Westwell-Roper C, Dai DL, Soukhatcheva G, Potter KJ, van Rooijen N, Ehses JA & Verchere CB. IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction. Journal of Immunology 2011 187 2755-2765. (doi:10.4049/jimmunol.1002854).
    • (2011) Journal of Immunology , vol.187 , pp. 2755-2765
    • Westwell-Roper, C.1    Dai, D.L.2    Soukhatcheva, G.3    Potter, K.J.4    Van Rooijen, N.5    Ehses, J.A.6    Verchere, C.B.7
  • 145
    • 42449091550 scopus 로고    scopus 로고
    • The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia
    • Sauter NS, Schulthess FT, Galasso R, Castellani LW & Maedler K. The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia. Endocrinology 2008 149 2208-2218. (doi:10.1210/en.2007-1059).
    • (2008) Endocrinology , vol.149 , pp. 2208-2218
    • Sauter, N.S.1    Schulthess, F.T.2    Galasso, R.3    Castellani, L.W.4    Maedler, K.5
  • 147
    • 84855605795 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress, obesity and diabetes
    • Cnop M, Foufelle F & Velloso LA. Endoplasmic reticulum stress, obesity and diabetes. Trends in Molecular Medicine 2012 18 59-68. (doi:10.1016/j.molmed.2011.07.010).
    • (2012) Trends in Molecular Medicine , vol.18 , pp. 59-68
    • Cnop, M.1    Foufelle, F.2    Velloso, L.A.3
  • 150
    • 47949127583 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner
    • Seo HY, Kim YD, Lee KM, Min AK, KimMK, Kim HS, Won KC, Park JY, Lee KU, Choi HS et al. Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner. Endocrinology 2008 149 3832-3841. (doi:10.1210/en.2008-0015).
    • (2008) Endocrinology , vol.149 , pp. 3832-3841
    • Seo, H.Y.1    Kim, Y.D.2    Lee, K.M.3    Min, A.K.4    Kim, M.K.5    Kim, H.S.6    Won, K.C.7    Park, J.Y.8    Lee, K.U.9    Choi, H.S.10
  • 151
    • 45749114525 scopus 로고    scopus 로고
    • The role of IRE1a in the degradation of insulin mRNA in pancreatic b-cells
    • Lipson KL, Ghosh R & Urano F. The role of IRE1a in the degradation of insulin mRNA in pancreatic b-cells. PLoS ONE 2008 3 e1648. (doi:10.1371/journal.pone.0001648).
    • (2008) PLoS ONE , vol.3 , pp. e1648
    • Lipson, K.L.1    Ghosh, R.2    Urano, F.3
  • 153
    • 84878777666 scopus 로고    scopus 로고
    • Signalling danger: Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation
    • Eizirik DL, Miani M & Cardozo AK. Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia 2013 56 234-241. (doi:10.1007/s00125-012-2762-3).
    • (2013) Diabetologia , vol.56 , pp. 234-241
    • Eizirik, D.L.1    Miani, M.2    Cardozo, A.K.3
  • 154
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • Lenzen S, Drinkgern J & Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radical Biology & Medicine 1996 20 463-466. (doi:10.1016/0891-5849(96)02051-5).
    • (1996) Free Radical Biology & Medicine , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 155
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxininteracting protein links oxidative stress to inflammasome activation
    • Zhou R, Tardivel A, Thorens B, Choi I & Tschopp J. Thioredoxininteracting protein links oxidative stress to inflammasome activation. Nature Immunology 2010 11 136-140. (doi:10.1038/ni.1831).
    • (2010) Nature Immunology , vol.11 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3    Choi, I.4    Tschopp, J.5
  • 156
  • 160
    • 59449100675 scopus 로고
    • The long-term response of diabetes mellitus to salicylate therapy: Report of a case
    • Gilgore SG & Rupp JJ. The long-term response of diabetes mellitus to salicylate therapy: report of a case. Journal of American Medical Association 1962 180 65-66. (doi:10.1001/jama.1962. 03050140067017c).
    • (1962) Journal of American Medical Association , vol.180 , pp. 65-66
    • Gilgore, S.G.1    Rupp, J.J.2
  • 161
    • 84876485218 scopus 로고    scopus 로고
    • A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance
    • Goldfine AB, Conlin PR, Halperin F, Koska J, Permana P, Schwenke D, Shoelson SE & Reaven PD. A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance. Diabetologia 2013 56 714-723. (doi:10.1007/s00125-012-2819-3).
    • (2013) Diabetologia , vol.56 , pp. 714-723
    • Goldfine, A.B.1    Conlin, P.R.2    Halperin, F.3    Koska, J.4    Permana, P.5    Schwenke, D.6    Shoelson, S.E.7    Reaven, P.D.8
  • 162
    • 38949119419 scopus 로고    scopus 로고
    • Salsalate improves glycemia and inflammatory parameters in obese young adults
    • Fleischman A, Shoelson SE, Bernier R & Goldfine AB. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care 2008 31 289-294. (doi:10.2337/dc07-1338).
    • (2008) Diabetes Care , vol.31 , pp. 289-294
    • Fleischman, A.1    Shoelson, S.E.2    Bernier, R.3    Goldfine, A.B.4
  • 163
    • 34248138844 scopus 로고    scopus 로고
    • Pharmacogenetics ofmetformin response: A step in the path toward personalized medicine
    • Reitman ML & Schadt EE. Pharmacogenetics ofmetformin response: A step in the path toward personalized medicine. Journal of Clinical Investigation 2007 117 1226-1229. (doi:10.1172/JCI32133).
    • (2007) Journal of Clinical Investigation , vol.117 , pp. 1226-1229
    • Ml, R.1    Ee, S.2


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