메뉴 건너뛰기




Volumn 55, Issue 2, 2015, Pages R12-R22

Stress kinases in the modulation of metabolism and energy balance

Author keywords

Adipose tissue; Brain and signal transduction; JNK; Metabolism; Obesity; p38; SAPK; Stress

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

EID: 84944313564     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-15-0146     Document Type: Review
Times cited : (63)

References (97)
  • 1
    • 0034708832 scopus 로고    scopus 로고
    • The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
    • Aguirre V, Uchida T, Yenush L, Davis R & White MF 2000 The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). Journal of Biological Chemistry 275 9047–9054. (doi:10.1074/jbc.275.12.9047)
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 9047-9054
    • Aguirre, V.1    Uchida, T.2    Yenush, L.3    Davis, R.4    White, M.F.5
  • 3
    • 78649466467 scopus 로고    scopus 로고
    • CNS leptin and insulin action in the control of energy homeostasis
    • Belgardt BF & Bruning JC 2010 CNS leptin and insulin action in the control of energy homeostasis. Annals of the New York Academy of Sciences 1212 97–113. (doi:10.1111/j.1749-6632.2010.05799.x)
    • (2010) Annals of the New York Academy of Sciences , vol.1212 , pp. 97-113
    • Belgardt, B.F.1    Bruning, J.C.2
  • 5
    • 84887016336 scopus 로고    scopus 로고
    • Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: A critical role for E-selectin
    • Bertola A, Park O & Gao B 2013 Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectin. Hepatology 58 1814–1823. (doi:10.1002/hep.26419)
    • (2013) Hepatology , vol.58 , pp. 1814-1823
    • Bertola, A.1    Park, O.2    Gao, B.3
  • 6
    • 33845653234 scopus 로고    scopus 로고
    • Uses for JNK: The many and varied substrates of the c-Jun N-terminal kinases
    • Bogoyevitch MA & Kobe B 2006 Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiology and Molecular Biology Reviews 70 1061–1095. (doi:10.1128/MMBR.00025-06)
    • (2006) Microbiology and Molecular Biology Reviews , vol.70 , pp. 1061-1095
    • Bogoyevitch, M.A.1    Kobe, B.2
  • 10
    • 1642293248 scopus 로고    scopus 로고
    • Spiegelman BM & Collins S 2004 p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
    • Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM & Collins S 2004 p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Molecular and Cellular Biology 24 3057–3067. (doi:10.1128/MCB.24.7.3057-3067.2004)
    • Molecular and Cellular Biology , vol.24 , pp. 3057-3067
    • Cao, W.1    Daniel, K.W.2    Robidoux, J.3    Puigserver, P.4    Medvedev, A.V.5    Bai, X.6    Floering, L.M.7
  • 12
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang L & Karin M 2001 Mammalian MAP kinase signalling cascades. Nature 410 37–40. (doi:10.1038/35065000)
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 15
    • 77955059513 scopus 로고    scopus 로고
    • Mechanisms and functions of p38 MAPK signalling
    • Cuadrado A & Nebreda AR 2010 Mechanisms and functions of p38 MAPK signalling. Biochemical Journal 429 403–417. (doi:10.1042/BJ20100323)
    • (2010) Biochemical Journal , vol.429 , pp. 403-417
    • Cuadrado, A.1    Nebreda, A.R.2
  • 16
    • 78650280416 scopus 로고    scopus 로고
    • JNK regulation of hepatic manifestations of the metabolic syndrome
    • Czaja MJ 2010 JNK regulation of hepatic manifestations of the metabolic syndrome. Trends in Endocrinology and Metabolism 21 707–713. (doi:10.1016/j.tem.2010.08.010)
    • (2010) Trends in Endocrinology and Metabolism , vol.21 , pp. 707-713
    • Czaja, M.J.1
  • 17
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • Davis RJ 2000 Signal transduction by the JNK group of MAP kinases. Cell 103 239–252. (doi:10.1016/S0092-8674(00)00116-1)
    • (2000) Cell , vol.103 , pp. 239-252
    • Davis, R.J.1
  • 18
    • 0032479983 scopus 로고    scopus 로고
    • Mitogen- and stressactivated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
    • Deak M, Clifton AD, Lucocq LM & Alessi DR 1998 Mitogen- and stressactivated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO Journal 17 4426–4441. (doi:10.1093/emboj/17.15.4426)
    • (1998) EMBO Journal , vol.17 , pp. 4426-4441
    • Deak, M.1    Clifton, A.D.2    Lucocq, L.M.3    Alessi, D.R.4
  • 19
    • 0033610788 scopus 로고    scopus 로고
    • Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis
    • Engelman JA, Lisanti MP & Scherer PE 1998 Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis. Journal of Biological Chemistry 273 32111–32120. (doi:10.1074/jbc.273.48.32111)
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 32111-32120
    • Engelman, J.A.1    Lisanti, M.P.2    Scherer, P.E.3
  • 20
    • 0034653850 scopus 로고    scopus 로고
    • Molecular determinants that mediate selective activation of p38 MAP kinase isoforms
    • Enslen H, Brancho DM & Davis RJ 2000 Molecular determinants that mediate selective activation of p38 MAP kinase isoforms. EMBO Journal 19 1301–1311. (doi:10.1093/emboj/19.6.1301)
    • (2000) EMBO Journal , vol.19 , pp. 1301-1311
    • Enslen, H.1    Brancho, D.M.2    Davis, R.J.3
  • 21
    • 84883494045 scopus 로고    scopus 로고
    • The immune cells in adipose tissue. Diabetes
    • Ferrante AW Jr 2013 The immune cells in adipose tissue. Diabetes, Obesity & Metabolism 15 (Suppl 3) 34–38. (doi:10.1111/dom.12154)
    • (2013) Obesity & Metabolism , vol.15 , pp. 34-38
    • Ferrante, A.W.1
  • 23
    • 78049339834 scopus 로고    scopus 로고
    • MAPK signalling in cellular metabolism: Stress or wellness?
    • Gehart H, Kumpf S, Ittner A & Ricci R 2010 MAPK signalling in cellular metabolism: stress or wellness? EMBO Reports 11 834–840. (doi:10.1038/embor.2010.160)
    • (2010) EMBO Reports , vol.11 , pp. 834-840
    • Gehart, H.1    Kumpf, S.2    Ittner, A.3    Ricci, R.4
  • 27
    • 84872142459 scopus 로고    scopus 로고
    • JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
    • Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA & Davis RJ 2013 JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 339 218–222. (doi:10.1126/science.1227568)
    • (2013) Science , vol.339 , pp. 218-222
    • Han, M.S.1    Jung, D.Y.2    Morel, C.3    Lakhani, S.A.4    Kim, J.K.5    Flavell, R.A.6    Davis, R.J.7
  • 28
    • 25844457693 scopus 로고    scopus 로고
    • Obesity
    • Haslam DW & James WP 2005 Obesity. Lancet 366 1197–1209. (doi:10.1016/S0140-6736(05)67483-1)
    • (2005) Lancet , vol.366 , pp. 1197-1209
    • Haslam, D.W.1    James, W.P.2
  • 30
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS 2006 Inflammation and metabolic disorders. Nature 444 860–867. (doi:10.1038/nature05485)
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 31
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-a: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS & Spiegelman BM 1993 Adipose expression of tumor necrosis factor-a: direct role in obesity-linked insulin resistance. Science 259 87–91. (doi:10.1126/science.7678183)
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 32
    • 0029847504 scopus 로고    scopus 로고
    • Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
    • Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE & Spiegelman BM 1996a Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274 1377–1379. (doi:10.1126/science.274.5291.1377)
    • (1996) Science , vol.274 , pp. 1377-1379
    • Hotamisligil, G.S.1    Johnson, R.S.2    Distel, R.J.3    Ellis, R.4    Papaioannou, V.E.5    Spiegelman, B.M.6
  • 33
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNFa- and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF & Spiegelman BM 1996b IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNFa- and obesity-induced insulin resistance. Science 271 665–668. (doi:10.1126/science.271.5249.665)
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 36
    • 4043073652 scopus 로고    scopus 로고
    • An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue
    • Jaeschke A, Czech MP & Davis RJ 2004 An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes and Development 18 1976–1980. (doi:10.1101/gad.1216504)
    • (2004) Genes and Development , vol.18 , pp. 1976-1980
    • Jaeschke, A.1    Czech, M.P.2    Davis, R.J.3
  • 39
    • 0033537827 scopus 로고    scopus 로고
    • Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor a by phosphorylation of a ligand-independent trans-activating domain
    • Juge-Aubry CE, Hammar E, Siegrist-Kaiser C, Pernin A, Takeshita A, Chin WW, Burger AG & Meier CA 1999 Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor a by phosphorylation of a ligand-independent trans-activating domain. Journal of Biological Chemistry 274 10505–10510. (doi:10.1074/jbc.274.15.10505)
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 10505-10510
    • Juge-Aubry, C.E.1    Hammar, E.2    Siegrist-Kaiser, C.3    Pernin, A.4    Takeshita, A.5    Chin, W.W.6    Burger, A.G.7    Meier, C.A.8
  • 40
    • 0037119417 scopus 로고    scopus 로고
    • Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression
    • Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S & Weir GC 2002 Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. Journal of Biological Chemistry 277 30010–30018. (doi:10.1074/jbc.M202066200)
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 30010-30018
    • Kaneto, H.1    Xu, G.2    Fujii, N.3    Kim, S.4    Bonner-Weir, S.5    Weir, G.C.6
  • 42
    • 44449100233 scopus 로고    scopus 로고
    • Macrophage deletion of p38a partially impairs lipopolysaccharide induced cellular activation
    • Kang YJ, Chen J, Otsuka M, Mols J, Ren S, Wang Y & Han J 2008 Macrophage deletion of p38a partially impairs lipopolysaccharide induced cellular activation. Journal of Immunology 180 5075–5082. (doi:10.4049/jimmunol.180.7.5075)
    • (2008) Journal of Immunology , vol.180 , pp. 5075-5082
    • Kang, Y.J.1    Chen, J.2    Otsuka, M.3    Mols, J.4    Ren, S.5    Wang, Y.6    Han, J.7
  • 43
  • 45
    • 0242268894 scopus 로고    scopus 로고
    • Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
    • Klover PJ, Zimmers TA, Koniaris LG & Mooney RA 2003 Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 52 2784–2789. (doi:10.2337/diabetes.52.11.2784)
    • (2003) Diabetes , vol.52 , pp. 2784-2789
    • Klover, P.J.1    Zimmers, T.A.2    Koniaris, L.G.3    Mooney, R.A.4
  • 46
    • 0035881737 scopus 로고    scopus 로고
    • A novel method to identify protein kinase substrates: EEF2 kinase is phosphorylated and inhibited by SAPK4/p38d
    • Knebel A, Morrice N & Cohen P 2001 A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38d. EMBO Journal 20 4360–4369. (doi:10.1093/emboj/20.16.4360)
    • (2001) EMBO Journal , vol.20 , pp. 4360-4369
    • Knebel, A.1    Morrice, N.2    Cohen, P.3
  • 48
    • 84882763389 scopus 로고    scopus 로고
    • In vivo JNK activation in pancreatic b-cells leads to glucose intolerance caused by insulin resistance in pancreas
    • Lanuza-Masdeu J, Arevalo MI, Vila C, Barbera A, Gomis R & Caelles C 2013 In vivo JNK activation in pancreatic b-cells leads to glucose intolerance caused by insulin resistance in pancreas. Diabetes 62 2308–2317. (doi:10.2337/db12-1097)
    • (2013) Diabetes , vol.62 , pp. 2308-2317
    • Lanuza-Masdeu, J.1    Arevalo, M.I.2    Vila, C.3    Barbera, A.4    Gomis, R.5    Caelles, C.6
  • 50
    • 84938293130 scopus 로고    scopus 로고
    • Estrogens and the control of energy homeostasis: A brain perspective
    • Lopez M & Tena-Sempere M 2015 Estrogens and the control of energy homeostasis: a brain perspective. Trends in Endocrinology and Metabolism 26 411–421. (doi:10.1016/j.tem.2015.06.003)
    • (2015) Trends in Endocrinology and Metabolism , vol.26 , pp. 411-421
    • Lopez, M.1    Tena-Sempere, M.2
  • 51
    • 84875900576 scopus 로고    scopus 로고
    • Imbalance between neutrophil elastase and its inhibitor a1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure
    • Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, Aubert G, Candelaria K, Thomas S, Shin DJ et al. 2013 Imbalance between neutrophil elastase and its inhibitor a1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metabolism 17 534–548. (doi:10.1016/j.cmet.2013.03.005)
    • (2013) Cell Metabolism , vol.17 , pp. 534-548
    • Mansuy-Aubert, V.1    Zhou, Q.L.2    Xie, X.3    Gong, Z.4    Huang, J.Y.5    Khan, A.R.6    Aubert, G.7    Candelaria, K.8    Thomas, S.9    Shin, D.J.10
  • 53
    • 33344468233 scopus 로고    scopus 로고
    • Neutrophils and immunity: Challenges and opportunities. Nature Reviews
    • Nathan C 2006 Neutrophils and immunity: challenges and opportunities. Nature Reviews. Immunology 6 173–182. (doi:10.1038/nri1785)
    • (2006) Immunology , vol.6 , pp. 173-182
    • Nathan, C.1
  • 55
    • 0036267472 scopus 로고    scopus 로고
    • Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    • Obici S, Feng Z, Karkanias G, Baskin DG & Rossetti L 2002 Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nature Neuroscience 5 566–572. (doi:10.1038/nn0602-861)
    • (2002) Nature Neuroscience , vol.5 , pp. 566-572
    • Obici, S.1    Feng, Z.2    Karkanias, G.3    Baskin, D.G.4    Rossetti, L.5
  • 61
    • 33747725908 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding protein a mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase
    • Qiao L, MacDougald OA & Shao J 2006 CCAAT/enhancer-binding protein a mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase. Journal of Biological Chemistry 281 24390–24397. (doi:10.1074/jbc.M603038200)
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 24390-24397
    • Qiao, L.1    Macdougald, O.A.2    Shao, J.3
  • 63
    • 84863936555 scopus 로고    scopus 로고
    • P38g and p38d kinases regulate the toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation
    • Risco A, del Fresno C, Mambol A, Alsina-Beauchamp D, MacKenzie KF, Yang HT, Barber DF, Morcelle C, Arthur JS, Ley SC et al. 2012 p38g and p38d kinases regulate the toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation. PNAS 109 11200–11205. (doi:10.1073/pnas.1207290109)
    • (2012) PNAS , vol.109 , pp. 11200-11205
    • Risco, A.1    Del Fresno, C.2    Mambol, A.3    Alsina-Beauchamp, D.4    Mackenzie, K.F.5    Yang, H.T.6    Barber, D.F.7    Morcelle, C.8    Arthur, J.S.9    Ley, S.C.10
  • 64
    • 3042841952 scopus 로고    scopus 로고
    • How free fatty acids inhibit glucose utilization in human skeletal muscle
    • Roden M 2004 How free fatty acids inhibit glucose utilization in human skeletal muscle. News in Physiological Sciences 19 92–96.
    • (2004) News in Physiological Sciences , vol.19 , pp. 92-96
    • Roden, M.1
  • 65
    • 77956185248 scopus 로고    scopus 로고
    • Jun NH2-terminal kinase 1 (JNK1): Roles in metabolic regulation of insulin resistance
    • Sabio G & Davis RJ 2010 Jun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends in Biochemical Sciences 35 490–496. (doi:10.1016/j.tibs.2010.04.004)
    • (2010) Trends in Biochemical Sciences , vol.35 , pp. 490-496
    • Sabio, G.1    Davis, R.J.2
  • 66
    • 84904062548 scopus 로고    scopus 로고
    • TNF and MAP kinase signalling pathways
    • Sabio G & Davis RJ 2014 TNF and MAP kinase signalling pathways. Seminars in Immunology 26 237–245. (doi:10.1016/j.smim.2014.02.009)
    • (2014) Seminars in Immunology , vol.26 , pp. 237-245
    • Sabio, G.1    Davis, R.J.2
  • 67
    • 57349101675 scopus 로고    scopus 로고
    • A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
    • Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK & Davis RJ 2008 A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322 1539–1543. (doi:10.1126/science.1160794)
    • (2008) Science , vol.322 , pp. 1539-1543
    • Sabio, G.1    Das, M.2    Mora, A.3    Zhang, Z.4    Jun, J.Y.5    Ko, H.J.6    Barrett, T.7    Kim, J.K.8    Davis, R.J.9
  • 72
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI 2000 Cellular mechanisms of insulin resistance. Journal of Clinical Investigation 106 171–176. (doi:10.1172/JCI10583)
    • (2000) Journal of Clinical Investigation , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 73
    • 58949093454 scopus 로고    scopus 로고
    • Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance
    • Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA & Czaja MJ 2009 Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology 49 87–96. (doi:10.1002/hep.22578)
    • (2009) Hepatology , vol.49 , pp. 87-96
    • Singh, R.1    Wang, Y.2    Xiang, Y.3    Tanaka, K.E.4    Gaarde, W.A.5    Czaja, M.J.6
  • 74
    • 33750823407 scopus 로고    scopus 로고
    • Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates
    • Solinas G, Naugler W, Galimi F, Lee MS & Karin M 2006 Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. PNAS 103 16454–16459. (doi:10.1073/pnas.0607626103)
    • (2006) PNAS , vol.103 , pp. 16454-16459
    • Solinas, G.1    Naugler, W.2    Galimi, F.3    Lee, M.S.4    Karin, M.5
  • 76
    • 77950408832 scopus 로고    scopus 로고
    • FTO effect on energy demand versus food intake
    • E1 discussion E2
    • Speakman JR 2010 FTO effect on energy demand versus food intake. Nature 464 E1 discussion E2. (doi:10.1038/nature08807)
    • (2010) Nature , vol.464
    • Speakman, J.R.1
  • 77
    • 68849084400 scopus 로고    scopus 로고
    • Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes
    • Standen CL, Kennedy NJ, Flavell RA & Davis RJ 2009 Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes. Molecular and Cellular Biology 29 4831–4840. (doi:10.1128/MCB.00155-09)
    • (2009) Molecular and Cellular Biology , vol.29 , pp. 4831-4840
    • Standen, C.L.1    Kennedy, N.J.2    Flavell, R.A.3    Davis, R.J.4
  • 80
    • 0031435337 scopus 로고    scopus 로고
    • Defective adipocyte differentiation in mice lacking the C/EBPb and/or C/EBPd gene
    • Tanaka T, Yoshida N, Kishimoto T & Akira S 1997 Defective adipocyte differentiation in mice lacking the C/EBPb and/or C/EBPd gene. EMBO Journal 16 7432–7443. (doi:10.1093/emboj/16.24.7432)
    • (1997) EMBO Journal , vol.16 , pp. 7432-7443
    • Tanaka, T.1    Yoshida, N.2    Kishimoto, T.3    Akira, S.4
  • 85
    • 33746101818 scopus 로고    scopus 로고
    • Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
    • Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M & Hotamisligil GS 2006 Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. PNAS 103 10741–10746. (doi:10.1073/pnas.0603509103)
    • (2006) PNAS , vol.103 , pp. 10741-10746
    • Tuncman, G.1    Hirosumi, J.2    Solinas, G.3    Chang, L.4    Karin, M.5    Hotamisligil, G.S.6
  • 86
    • 52349105273 scopus 로고    scopus 로고
    • A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity
    • Vallerie SN, Furuhashi M, Fucho R & Hotamisligil GS 2008 A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. PLoS ONE 3 e3151. (doi:10.1371/journal.pone.0003151)
    • (2008) Plos ONE , vol.3
    • Vallerie, S.N.1    Furuhashi, M.2    Fucho, R.3    Hotamisligil, G.S.4
  • 89
    • 84873198464 scopus 로고    scopus 로고
    • CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age
    • Vogt MC & Bruning JC 2013 CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age. Trends in Endocrinology and Metabolism 24 76–84. (doi:10.1016/j.tem.2012.11.004)
    • (2013) Trends in Endocrinology and Metabolism , vol.24 , pp. 76-84
    • Vogt, M.C.1    Bruning, J.C.2
  • 96
    • 1242316958 scopus 로고    scopus 로고
    • JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
    • Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN, Xiang J & Lin A 2004 JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Molecular Cell 13 329–340. (doi:10.1016/S1097-2765(04)00028-0)
    • (2004) Molecular Cell , vol.13 , pp. 329-340
    • Yu, C.1    Minemoto, Y.2    Zhang, J.3    Liu, J.4    Tang, F.5    Bui, T.N.6    Xiang, J.7    Lin, A.8
  • 97
    • 79551600855 scopus 로고    scopus 로고
    • Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle inmice
    • Zhang X, Xu A, Chung SK, Cresser JH, Sweeney G, Wong RL, Lin A & Lam KS 2011 Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle inmice. Diabetes 60 486–495. (doi:10.2337/db10-0650)
    • (2011) Diabetes , vol.60 , pp. 486-495
    • Zhang, X.1    Xu, A.2    Chung, S.K.3    Cresser, J.H.4    Sweeney, G.5    Wong, R.L.6    Lin, A.7    Lam, K.S.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.